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Quantitative assessment of the association between rs2046210 at 6q25.1 and breast cancer risk.

Authors :
Xi Wu
Qing-Qing Xu
Liang Guo
Chuan-Ting Yu
Yu-Yu Xiong
Zhi-Yun Wei
Ran Huo
Sheng-Tian Li
Lu Shen
Jia-Min Niu
Lu Liu
Yi Lin
Lin He
Sheng-Ying Qin
Source :
PLoS ONE, Vol 8, Iss 6, p e65206 (2013)
Publication Year :
2013
Publisher :
Public Library of Science (PLoS), 2013.

Abstract

Genome-wide association studies (GWAS) have identified several genetic susceptibility loci for breast cancer (BC). One of them, conducted among Chinese women, found an association of rs2046210 at 6q25.1 with the risk of BC recently. Since then, numerous association studies have been carried out to investigate the relationship between this polymorphism and BC risk in various populations. However, these have yielded contradictory results. We therefore performed a meta-analysis to clarify this inconsistency. Overall, a total of 235003 subjects based on 13 studies were included in our study. Significantly increased BC risk was detected in the pooled analysis [allele contrast: OR = 1.13, 95%CI = 1.10-1.17, P(Z)

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
6
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.786a7fee76c542f6be1f67bb00e0eb72
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0065206