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Your search keyword '"Zheng, Xiao-ling"' showing total 125 results
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125 results on '"Zheng, Xiao-ling"'

24. Presence of pink-color sign within 1 min after iodine staining has high diagnostic accordance rate for esophageal high-grade intraepithelial neoplasia/invasive cancer.

Author

Zheng, Jia-Yao, Chen, Ya-Hua, Chen, Yang-Yang, Zheng, Xiao-Ling, Zhong, Shi-Shun, Deng, Wan-Yin, Zheng, Jin-Hui, Guo, Xian-Bin, Gao, Li-Ying, and Liang, Wei

Subjects
ESOPHAGEAL tumors, GASTROSCOPY, IODINE, MEDICAL records, RESEARCH evaluation, STAINS & staining (Microscopy), TIME, RETROSPECTIVE studies, ENDOSCOPIC gastrointestinal surgery, TUMOR grading, PANCREATIC intraepithelial neoplasia, DIAGNOSIS
Abstract

Background/Aim: The dramatic color change after iodine staining (from white-yellow to pink after 2–3 min), designated as the "pink-color sign" (PCS), is indicative of esophageal high-grade intraepithelial neoplasia (HGIN) or an invasive lesion. However, no study has yet examined the association between the time of PCS appearance and histopathology. We investigated the association between the time of PCS appearance and esophageal histopathology in 456 lesions of 438 patients who were examined for suspected esophageal cancer. Materials and Methods: The records of 495 consecutive patients who had suspected esophageal cancer based on gastroscopy and who underwent Lugol's chromoendoscopy from January 2015 to March 2018 were retrospectively reviewed. The time of PCS appearance was recorded in all patients, and tissue specimens were examined. Results: We examined 456 lesions in 438 patients. Use of PCS positivity at 2 min for the diagnosis of HGIN/invasive cancer had a sensitivity of 84.1%, a specificity of 72.7%, and an accuracy of 80.4%. We classified the PCS-positive patients in whom the time of PCS appearance was recorded (168 lesions) into 4 groups: 0–30, 31–60, 61–90, and 91–120 s. Based on a 60-s time for appearance of the PCS, the area under the receiver operating characteristic curve was 0.897, indicating good validity. At the optimal cutoff value of 60 s, the sensitivity was 90.2% and the specificity was 82.3%. The appearance of the PCS within 60 s had a diagnostic accordance rate of 88.6%, significantly higher than appearance of the PCS within 2 min (79.7%, P < 0.05). Conclusion: Appearance of the PCS within 1 min after iodine staining has a higher diagnostic accordance rate for esophageal HGIN/invasive cancer than appearance of the PCS at 2 min. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Efficient delivery of Notch1 siRNA to SKOV3 cells by cationic cholesterol derivative-based liposome

Author

Zhao,Yunchun, Zhang,Li, Feng,Shi-Sen, Hong,Lu, Zheng,Hai-Li, Chen,Li-Li, Zheng,Xiao-Ling, Ye,Yi-Qing, Zhao,Meng-Dan, Wang,Wen-Xi, Zheng,Cai-Hong, Zhao,Yunchun, Zhang,Li, Feng,Shi-Sen, Hong,Lu, Zheng,Hai-Li, Chen,Li-Li, Zheng,Xiao-Ling, Ye,Yi-Qing, Zhao,Meng-Dan, Wang,Wen-Xi, and Zheng,Cai-Hong

Abstract

Yun-Chun Zhao,1 Li Zhang,2 Shi-Sen Feng,3 Lu Hong,3 Hai-Li Zheng,3 Li-Li Chen,4 Xiao-Ling Zheng,1 Yi-Qing Ye,1 Meng-Dan Zhao,1 Wen-Xi Wang,3 Cai-Hong Zheng1 1Pharmacy Department, Women’s Hospital, 2Pharmacy Department, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 3Department of Pharmaceutic Preparation, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 4Department of Gynecologic Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Abstract: A novel cationic cholesterol derivative-based small interfering RNA (siRNA) interference strategy was suggested to inhibit Notch1 activation in SKOV3 cells for the gene therapy of ovarian cancer. The cationic cholesterol derivative, N-(cholesterylhemisuccinoyl-amino-3-propyl)-N, N-dimethylamine (DMAPA-chems) liposome, was incubated with siRNA at different nitrogen-to-phosphate ratios to form stabilized, near-spherical siRNA/DMAPA-chems nanoparticles with sizes of 100–200 nm and zeta potentials of 40–50 mV. The siRNA/DMAPA-chems nanoparticles protected siRNA from nuclease degradation in 25% fetal bovine serum. The nanoparticles exhibited high cell uptake and Notch1 gene knockdown efficiency in SKOV3 cells at an nitrogen-to-phosphate ratio of 100 and an siRNA concentration of 50 nM. They also inhibited the growth and promoted the apoptosis of SKOV3 cells. These results may provide the potential for using cationic cholesterol derivatives as efficient nonviral siRNA carriers for the suppression of Notch1 activation in ovarian cancer cells. Keywords: siRNA, cationic cholesterol derivative, Notch1, ovarian cancer cells

Published
2016

26. Experimental study on decoupling modeling micro-fluid dispensing process

Author

Zheng Xiao-ling, Chen Cong-ping, Zhang Tao, and Dong Xiao-gang

Subjects
Engineering, business.industry, Compressed air, Sealant, Microfluidics, Linear model, Mechanical engineering, Inner diameter, Control engineering, Solid modeling, Adhesive, business, Decoupling (electronics)
Abstract

During micro-fluid dispensing process, pressurized air drives fluid materials (such as adhesive, sealant) through a circular tube with micro inner diameter onto substrates. This process is affected by some coupled factors and extremely difficult to develop an accurate physical model. Contrarily, an applied model may be more useful and effective. In this paper, by analysis the dispensing process, an applied decoupling linear model of micro-fluid dispensing process was developed step by step, through adding the variables one by one to a nominal model, a completed dispensing model was obtained. Experiments on a typical commercial dispensing system were carried out to test the model, the result shown the model developed in this paper working effectively.

Published
2011

49. Preparation of poly(vinylphenylboronic acid) chain grafted poly(glycidylmethacrylate-co-ethylenedimethacrylate) beads for the selective enrichment of glycoprotein.

Author

Zhang, Jing, Ni, Yan‐li, and Zheng, Xiao‐ling

Subjects
POLYMERIZATION, GLYCOPROTEINS, CHEMICAL reactions, ALPHA fetoproteins, BORONIC acids, NONCARBOXYLIC acids, ORGANOBORON compounds
Abstract

Surface-initiated atom transfer radical polymerization was successfully used to prepare 4-vinylphenylboronic acid functionalized poly(glycidylmethacrylate-co-ethylenedimethacrylate) beads for the selective enrichment of glycoprotein from complex biological samples in this study. The modified bead surfaces were characterized using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The sorption behaviors, including adsorption isotherms, incubation time, and pH effect, were investigated. The results demonstrated that the boronated beads have a high affinity for glycoprotein, which is due to the well-defined boronic acid brushes on the beads surfaces. Furthermore, the polyvinylphenylboronic acid grafted poly(glycidylmethacrylate-co-ethylenedimethacrylate) beads were used to efficiently enrich and purify glycoprotein from real egg white samples and α-fetoprotein from human serum samples. The mass spectrometry results demonstrated that the polyvinylphenylboronic acid grafted poly(glycidylmethacrylate-co-ethylenedimethacrylate) beads are a suitable material for the enrichment of glycosylated protein from complex biological samples. [ABSTRACT FROM AUTHOR]

Published
2015
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