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Fast growing wood in planted forest had defects such as low mechanical strength, poor dimensional instability, etc.. In order to achieve efficient utilization of wood, it was necessary to be modified to improve its properties, and impregnation treatment was a common method of modification.In this paper, the mechanism of wood impregnation modification was briefly introduced, and the related researches on the improvement of wood dimensional stability by impregnation of fast growing wood were reviewed, including the impregnation modification of organic and inorganic materials and the combination of impregnation modification of both, impregnation modification combined with high-temperature heat treatment, etc., and the research direction of wood impregnation modification was pointed out. [ABSTRACT FROM AUTHOR]

The scavenging effects of Maillard reaction products (MRPs) derived from L-lysine-D-arabinose against on hydroxyl radical (⋅ OH), superoxide anion radical (O2- ⋅) and DPPH radical (DPPH ⋅) under different reaction temperatures, reaction times, initial pH values and substrate molarratios were investigated, and the reaction conditions were optimized by uniform optimized experiment. Under the optimum conditions, the free radical scavenging rates for MRPs against ⋅ OH, O2- ⋅ and DPPH ⋅ were 47.28%, 75. 16% and 89.81%, respectively. Therefore, the MRPs derived from L-lysine-D-arabinose could not only be used for food coloring and flavor enhancement, but also help to prevent the diseases caused by various free radical damages in vivo. [ABSTRACT FROM AUTHOR]

In order to investigate the antioxidant activity of Maillard reaction products ( MRPs) in the methanol solvent,the glycine-glucose simulation system was adopted,with DPPH free radical scavenging as antioxidant activity index of MRPs and pure water system of MRPs antioxidant activity as the contrast. The optimum concentration of methanol was investigated. Under this methanol concentration, the effect of reaction temperature, reaction time, pH and concentration of reactants on MRPs oxidation activity were studied, and optimum technological conditions were obtained by uniform test. The results showed that under the 40% methanol concentration as the solvent of glycine-glucose simulation system,the DPPH free radical scavenging rate of MRPs was the highest,the antioxidant activity was the optimal. The optimum technological conditions were as follows :temperature 127 °C, 60 min reaction time,initial pH =8.0,the ratio of glycine and glucose 2.5 : 1. [ABSTRACT FROM AUTHOR]

Soybean protein isolate (SPI) with a moisture content of 60% was thermo-mechanically treated torque rheometer at 30 °C and 90 °C for 2 min, 15 min and 30 min respectively, and characterized by Fourier transform infrared (FT-IR) spectroscopy. The results showed that after thermo-mechanical treatments, the symmetrical and asymmetrical stretching of C--H bonds in --CH2 resides became weak and even disappeared the stretching vibration and asymmetrical stretching of C--H bonds drifted to higher position. The a-helix and β-turn decreased accompanying with β- sheet and random coil increased. For that lower moisture content SPI system, the mechanical effect during thermo- mechanical processing may be the major contributor to the transformation of secondary protein structure. [ABSTRACT FROM AUTHOR]

The clinical use of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of non-small cell lung cancer was limited by the drug resistance caused by EGFR C797S mutation. Therefore, in order to overcome the drug resistance, we designed and synthesized a series of 2-aminopyrimidine derivatives as EGFR C797S -TKIs. Among these compounds, compounds A5 and A13 showed significant anti-proliferative activity against the KC-0116 (EGFR del19/T790M/C797S ) cell line with high selectivity. A5 inhibited EGFR phosphorylation and induced apoptosis of KC-0116 cell, arrested KC-0116 cell at G2/M phase. Molecular docking results showed that A5 and brigatinib bind to EGFR in a similar pattern. In addition to forming two important hydrogen bonds with Met793 residue, A5 also formed a hydrogen bond with Lys745 residues, which may play an important role for the potent inhibitory activity against EGFR del19/T790M/C797S . Based on these results, A5 turned out to be effective reversible EGFR C797S -TKIs which can be further developed., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

The development of nonalcoholic fatty liver disease (NAFLD) is closely related to the fatty acid (FA) uptake. This study aimed to investigate the effect of Krüppel-like factor 9 (KLF9) on CD36 (typical fatty acid translocase), hepatocellular lipid metabolism as well as the development and progression of nonalcoholic fatty liver. High-fat diet-induced obese C57BL/6J mice and db/db mice were used to test the expression levels of Klf9 and Cd36 in the livers. The primary hepatocytes were isolated from C57BL/6J mice, treated with Ad-GFP, Ad-Klf9, Ad-shCtrl or Ad-shKlf9, and then incubated with oleic acid and palmitic acid for 24 h. Liver-specific knockout of Klf9 mice were established. The protein levels and relative mRNA levels were examined by Western blot and real-time PCR, respectively. Triglyceride content was determined by using an assay kit. Lipid content was determined by Oil Red O staining. The results showed that: (1) Klf9 expression levels were increased in the livers of high-fat diet-induced obese mice and db/db mice, compared to their respective control mice. (2) Adenovirus-mediated overexpression of Klf9 in primary hepatocytes increased Cd36 expression and cellular triglyceride contents. (3) In contrast, adenovirus-mediated knockdown of Klf9 expression in primary hepatocytes by Ad-shKlf9 decreased Cd36 expression and cellular triglyceride contents. (4) Finally, Klf9 deficiency decreased liver Cd36 expression and alleviated fatty liver phenotype of high-fat diet-induced obese mice. These results suggest that KLF9 can regulate hepatic lipid metabolism and development of NAFLD by promoting the expression of CD36.