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Highly pathogenic bacterial infections are a major threat to human health, and the resulting drug resistance is beginning to pose a major clinical threat. To combat multidrug-resistant bacterial infections, there is an urgent need to develop antimicrobial drugs that are highly effective, environmentally friendly, and able to prevent the emergence of bacterial resistance. In this paper, Co4N nanozymes were successfully synthesized by pyrolysis of a presynthesized Co-containing metal organic framework (Co-MOF). Its peroxide and lactate oxidase activity and antimicrobial properties were investigated. Without the addition of exogenous H2O2, the nanozymes can initially generate H2O2 by catalyzing lactic acid and then produce highly active •OH from H2O2. This approach overcomes the obstacle of insufficient H2O2 to achieve a satisfactory antimicrobial effect. Furthermore, the local high temperature generated by Co4N under 808 nm laser irradiation further enhanced the antibacterial effect. These results showed that the nanozyme possesses broad-spectrum antimicrobial activity against Escherichia coli and Staphylococcus aureus , with an inhibition rate as high as 99% within 2 h. Meanwhile, the enzyme has good biocompatibility, paving a way for the application of MOF materials in biomedical fields. [ABSTRACT FROM AUTHOR]

A bovine serum albumin (BSA)-assisted ultrasonication strategy was developed for the synthesis of CsPbBr3 nanocrystals (NCs) with stable fluorescence properties in aqueous solution. Such a preparation method is simple, fast and does not require complex equipment. The results show that the synthesized CsPbBr3 NCs are homogeneous in particle size and have good solubility and stability in water. The CsPbBr3 NCs have been utilized as fluorescence probe for rapid detection of hydrogen sulfide (H2S) in human serum. The reaction of H2S with the lead sites on the surface of CsPbBr3 NCs produces lead sulfide (PbS), resulting in the decrease of fluorometric intensity of CsPbBr3 NCs. Our designed fluorescent assay has a linear S2− detecting range of 10 ~ 800 nM with a detection limit of 7.05 nM. The assay was used to determine H2S in human serum with spiked recoveries ranging from 94.98% to 102.69%. This work opens new avenues for the application of halide lead perovskite in different biosensing areas. [ABSTRACT FROM AUTHOR]

The complement system is an important part of the innate immune system, including more than 50 secretory proteins and membrane-bound proteins, and it contributes to the clearance of apoptotic cells and invading pathogens to limit inflammatory immune responses and maintaining brain homeostasis. Complement activity is strictly regulated to protect cells from random attacks or to prevent the deposition of complement proteins in physiological cases. However, overactivation or abnormal regulation of the complement cascade in the brain can lead to neuronal damage and brain dysfunction. Recent studies have pointed out that changes in complement molecules exist in patients with psychiatric diseases and play an important role in the occurrence and development of diseases by regulating the function of neurons and glial cells. Therefore, summarizing the latest research progress of complement system in psychiatric diseases such as schizophrenia, autism spectrum disorder, major depression, bipolar disorder and anxiety disorder can provide new ideas for preventing and controlling psychiatric diseases caused by abnormal activation of complement system.