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The esthesioneuroblastoma (ENB) is a rare malignant sinonasal tumor of neuroectodermal origin. This study aimed to improve the understanding of the clinical features by reviewing the literature and analyzing the medical records of patients diagnosed with ENB in our institution between 2012 and 2019. A total of 6 cases of ENB were available for analysis. The mean age at the time of diagnosis was 36 years. The main complaints at presentation were the rhinologic signs. Tumors were classified as stage C of Kadisk in 3 cases and stage D in the others. According to TNM (modified by Dulguerov), 2 patients were T3N0M0, one T4N0M0, one T3N1M0, and two T4N1M0. The diagnosis of ENB was based on pathological examination. According to Hyams histological grading, low-grade lesions (Hyams I and II) were seen in 2 cases, high-grade undifferentiated lesions (Hyams III and IV) were seen in 4. Of the 6 patients, 4 received surgery. The surgical approaches mainly included an endoscopic endonasal resection in 2 cases, a cranial-facial resection surgery in 1 case, and an expanded endoscopic endonasal approach in combination with craniotomy in 1 case. Four patients received adjuvant radiotherapy (RT). RT dose ranged from 60 to 70 Gy. A total of 3 patients had lymph node metastasis and received RT of the neck. Chemotherapy was delivered in 2 patients. After a mean follow-up of 4.5 years, 4 patients were free of recurrence. Unfortunately, 1 patient died from a progressive disease 6 months after RT. ENB is a rare locally aggressive tumor of the nasosinusal cavities. The first-line treatment for resectable tumors should include primary surgical resection with adjuvant RT. However, this tumor remains of poor prognosis. Therefore, long-term close follow-up based on symptoms, endoscopy, and imaging is essential.

Basal cell carcinoma is a common, slowly growing, locally aggressive, and rarely metastatic skin cancer. Primary BCCs of the external auditory canal are extremely rare. A 67-year-old patient presented chronic otitis media associated with a mass in the concha and the external auditory canal of the left ear. The patient was diagnosed with basal cell carcinoma of the EAC. Locoregional assessment on a CT scan revealed thickening of soft tissues in the external left auricle and external auditory canal. She underwent surgery. Given the insufficient margins, adjuvant radiotherapy was indicated. Radiotherapy was performed with the intensity-modulated radiation therapy technique in order to the overcome anatomical complexity of the region, cover the tumor bed, and preserve the organs at risk. BCC of the EAC is a rare and challenging entity, whose management is multidisciplinary. The main goal is to avoid local recurrence, as well as to improve the patient’s quality of life.

L'objectif de l'étude et d'Analyser les caractéristiques épidémiologiques, cliniques, thérapeutiques et évolutives du carcinome indifférencié du nasopharynx de l'adulte. Il s'agit d'une étude cohorte rétrospective portant sur 163 patients âgés de 17 ans et plus, traités pour un carcinome indifférencié du nasopharynx non métastatique. L'âge moyen des patients était de 46,5ans, avec un sexe-ratio de 1,7. 35,57% des patients étaient atteints de tumeurs localement évoluées (T3-T4) et 52,27% avec une atteinte ganglionnaire régionale avancée (N2-N3). Sur le plan thérapeutique une chimiothérapie neoadjuvante a été réalisée chez 77% des patients et 93,8% des patients ont bénéficié d'une radio-chimiothérapie concomitante. Après un recul moyen de 40,8 mois la survie globale était de 92,9% et la survie sans récidive (SSR) était de 78,9%. L'analyse de la survie sans récidive SSR en fonction des différents facteurs pronostiques a montré une différence statistiquement significative pour l'atteint ganglionnaire avec des taux de SSR à trois ans de 88%, 82,6%, 80,8% et 61,5% en cas de tumeur classée N0, N1, N2 et N3 respectivement (p = 0,02). Le cancer du nasopharynx est une maladie complexe, mais des progrès ont été accomplis grâce à des percées en radiothérapie et en biologie moléculaire. La radio-chimiothérapie concomitante représente le standard thérapeutique des stades cliniques supérieur ou égal à T2, ou supérieur ou égal à N1. Les techniques innovantes d'irradiation semblent prometteuses et pourraient pallier aux problèmes de toxicité tardive tout en assurant un excellent taux de contrôle local.

Bien que le lymphome malin Hodgkinien ou (maladie de Hodgkin) ne représente que 10% de tous les lymphomes, c'est l'un des sous-types de lymphomes les plus communs diagnostiqués pendant la grossesse, en grande partie à cause de l'incidence maximale de la maladie qui coïncide avec l'âge de reproduction. La prise en charge d'une patiente enceinte atteinte d'une maladie de Hodgkin nécessite une approche multidisciplinaire, ainsi qu'une communication efficace avec le patient et sa famille. L'objectif est d'optimiser les chances de guérison de la mère tout en permettant l'accouchement d'un enfant en bonne santé. Nous rapportant un cas rare d'une patiente enceinte diagnostiquée pour une maladie de Hodgkin à 17 semaines d'aménorrhée.

Le gliosarcome est une tumeur primitive mixte du système nerveux central, caractérisée par une prolifération biphasique associant un contingent glial de type glioblastome et un contingent sarcomateux. L'âge moyen de survenue de cette tumeur varie de 40 à 60 ans, avec un sex-ratio homme/femme de 1,8/1. Nous rapportons ici deux cas de gliosarcome traités dans notre service Le traitement standard consiste en une résection chirurgicale de la tumeur suivie d'une radiothérapie externe et parfois d'une chimiothérapie.

Introduction:The announcement of the diagnosis of cancer is the first step in the management; it conditions the experience of the disease and compliance with treatment. Objective: The objective of this study was to assess patients' feelings about the diagnosis of cancer and its psychological impact. Methodology: We conducted a monocentric cross-sectional study at Hassan II university hospital; we included 203 newly diagnosed patients over the year 2021. We assessed patient perception after the announcement and identified its psychological impact through the MINI scale. Results: The average age was 52 (18-92). 65% were female, 51.7% were urban and 59.1% had a low income. 72.0% of patients felt that the time spent on the announcement was not sufficient, 68.5% were not involved in the therapeutic choice and 68.1% of our patients felt that their social, family and economic situation was not taken into account. In terms of overall patient perceptions of the announcement, 77.3% of participants were satisfied. Three main psychiatric disorders were identified, major depression (37.9%), generalized anxiety (30.5%), and post-traumatic stress (8.4%). Patients who were dissatisfied with the quality of diagnosis announcement are 5.4 times more likely to have major depression independently of other factors (P<0.0001). Conclusion: In our social context, the announcement of a cancer diagnosis can have psychological repercussions on patients or the interest in setting up a personalized announcement consultation. [ABSTRACT FROM AUTHOR]

Background: Clear cell carcinoma (CCC) is a low-grade malignant tumor that usually appears in the minor salivary glands of the oropharynx and other sites and is a rare feature of salivary gland tumors. Methods: We present here the case of a 58-year-old woman with no medical history. She consulted for swelling under the left mandible. On clinical examination, the patient had a swelling of the left tonsil. A biopsy was performed and histological and immunohistochemical results were used to diagnose a Hyalinizing clear cell carcinoma of the left tonsil. Cervical facial CT scan showed a tumor process of the left tonsil compartment with bilateral cervical lymphadenopathies. No other lesions were detected in the systemic evaluation. Surgery was not feasible in this patient and therefore the decision to opt for concurrent chemo-radiotherapy was made. Results: The patient was reviewed after 1 month. Clinically, it shows a regression of cervical adenopathies and a decrease in the volume of the tonsillar tumor mass. Skin reactions almost resolved. The patient was doing well. Conclusion: concurrent chemo-radiotherapy is used in the treatment of locally advanced clear-cell carcinoma of the tonsils that escape surgery with good disease control results. [ABSTRACT FROM AUTHOR]