1. [Effect of multi-walled carbon nanotubes on the morphofunctional state of the small intestine cells of mice].
- Author
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Beliaeva NN, Mikhaĭlova RI, Sycheva LP, Savostikova ON, Zelenkina EA, Gasimova ZM, Alekseeva AV, Ryzhova IN, and Altaeva AA
- Subjects
- Animals, Dose-Response Relationship, Drug, Drinking, Intestinal Mucosa ultrastructure, Intestine, Small ultrastructure, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Nanotubes, Carbon chemistry, Surface Properties, Time Factors, Water Pollutants, Chemical chemistry, Cell Proliferation drug effects, Intestinal Mucosa drug effects, Intestine, Small drug effects, Nanotubes, Carbon toxicity, Water Pollutants, Chemical toxicity
- Abstract
The experiment was conducted in male mice SBAchS57Vl/6 and Balb/c, which consumed water, obtained from the use of carbon nanotubes. in a free drinking regimen for 2 weeks (mice SBAchS57Vl/6) and 2 months (mice Balb/c) Control group consisted of three groups of animals: intact and mice received fine coal in the same concentrations as under the impact of the nanotubes. Under exposure to the maximal of the studied concentration of carbon nanotubes a significant change in the fine structure of the villi of the small intestine was found in the form of increasing the number of unstructured villi and proliferation of epithelial cells, most pronounced in duration of exposure until 2 months.
- Published
- 2012