1. NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer
- Author
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Berlin, Alejandro, Lalonde, Emilie, Sykes, Jenna, Zafarana, Gaetano, Chu, Kenneth C, Ramnarine, Varune R, Ishkanian, Adrian, Sendorek, Dorota HS, Pasic, Ivan, Lam, Wan L, Jurisica, Igor, van der Kwast, Theo, Milosevic, Michael, Boutros, Paul C, and Bristow, Robert G
- Subjects
Genetics ,Aging ,Prostate Cancer ,Clinical Research ,Cancer ,Urologic Diseases ,4.1 Discovery and preclinical testing of markers and technologies ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Biomarkers ,Tumor ,Cell Cycle Proteins ,Comparative Genomic Hybridization ,DNA Damage ,Disease-Free Survival ,Genomic Instability ,Humans ,Male ,Nuclear Proteins ,Precision Medicine ,Predictive Value of Tests ,Prostatectomy ,Prostatic Neoplasms ,Radiation Tolerance ,Radiotherapy ,Image-Guided ,Treatment Outcome ,prostate cancer ,NBN ,MRN complex ,radiotherapy ,biomarker ,aCGH ,Oncology and Carcinogenesis - Abstract
Despite the use of clinical prognostic factors (PSA, T-category and Gleason score), 20-60% of localized prostate cancers (PCa) fail primary local treatment. Herein, we determined the prognostic importance of main sensors of the DNA damage response (DDR): MRE11A, RAD50, NBN, ATM, ATR and PRKDC. We studied copy number alterations in DDR genes in localized PCa treated with image-guided radiotherapy (IGRT; n=139) versus radical prostatectomy (RadP; n=154). In both cohorts, NBN gains were the most frequent genomic alteration (14.4 and 11% of cases, respectively), and were associated with overall tumour genomic instability (p
- Published
- 2014