Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Authors :: Lalonde, Emilie
Ishkanian, Adrian S.
Sykes, Jenna
Fraser, Michael
Ross-Adams, Helen
Erho, Nicholas
Dunning, Mark J.
Halim, Silvia
Lamb, Alastair D.
Moon, Nathalie C.
Zafarana, Gaetano
Warren, Anne Y.
Meng, Xianyue
Thoms, John
Grzadkowski, Michal R.
Berlin, Alejandro
Have, Cherry L.
Ramnarine, Varune R.
Yao, Cindy Q.
Malloff, Chad A.
Lam, Lucia L.
Xie, Honglei
Harding, Nicholas J.
Mak, Denise Y. F.
Chu, Kenneth C.
Chong, Lauren C.
Sendorek, Dorota H.
P'ng, Christine
Collins, Colin C.
Squire, Jeremy A.
Jurisica, Igor
Cooper, Colin
Eeles, Rosalind
Pintilie, Melania
Dal Pra, Alan
Davicioni, Elai
Lam, Wan L.
Milosevic, Michael
Neal, David E.
van der Kwast, Theodorus
Boutros, Paul C.
Bristow, Robert G.
Publication Year :: 2014
Abstract: Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

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