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117 results on '"ZHENG Ziyi"'

1. Regulatory role of lateral hypothalamus hypocretin neurons-medial entorhinal cortex neural circuit in spatial memory in mice

Author

LIAO Yixiang, ZHENG Ziyi, CHENG Xiaofang, and WEN Ruyi

Subjects
lateral hypothalamus, hypocretins, medial entorhinal cortex, spatial memory, Medicine (General), R5-920
Abstract

Objective To explore the regulatory effects of hypocretin (Hcrt) neurons in lateral hypothalamus (LHHcrt)-medial entorhinal cortex (MEC) circuit on spatial memory. Methods The activity pattern of Hcrt neurons in spatial memory was recorded using in vivo fiber photometry.The morphological characteristics of connections between the Hcrt neurons and MEC neurons were identified with retrograde nerve tracer technique.Chemogenetics and optogenetics were subsequently adopted to confirm the effects of LHHcrt-MEC pathway on spatial memory. Results The optical fiber recording showed high levels of activation of Hcrt neurons during the spatial memory-related behaviors (P < 0.01).The retrograde neural tracer test indicated that Hcrt neurons were projected to MEC which was associated with spatial memory, and those projected Hcrt neurons were confirmed being activated in spatial memory.Inhibition of the LHHcrt-MEC pathway by chemogenetics significantly prolonged the latency of mice to find the correct spatial location of food (P < 0.05), and increased the number of errors in the process of finding food (P < 0.05).However, photoactivation of the LHHcrt-MEC pathway by optogenetics remarkably reduced the latency of mice to find the food location at the initial training blocks (P < 0.05). Conclusion Hcrt neurons are involved in spatial memory, and those Hcrt neurons projected from LH to the shallow layer of MEC are activated in spatial memory.Chemogenetic inhibition of the LHHcrt-MEC pathway impairs spatial memory, while optogenetic activation of this pathway enhances the function.

Published
2023
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3. Theoretical Model Construction of Deformation-Force for Soft Grippers Part II: Displacement Control Based Intrinsic Force Sensing

Author

Dong, Huixu, Zheng, Ziyi, Guo, Haotian, Yang, Sihao, Qiu, Chen, Dai, Jiansheng, and Chen, I-Ming

Subjects
Computer Science - Robotics
Abstract

Force-aware grasping is an essential capability for most robots in practical applications. Especially for compliant grippers, such as Fin-Ray grippers, it still remains challenging to build a bidirectional mathematical model that mutually maps the shape deformation and contact force. Part I of this article has constructed the force-displacement relationship for design optimization through the co-rotational theory. In Part II, we further devise a displacement-force mathematical model, enabling the compliant gripper to precisely estimate contact force from deformations sensor-free. The presented displacement-force model elaborately investigates contact forces and provides force feedback for a force control system of a gripper, where deformation appears as displacements in contact points. Afterward, simulation experiments are conducted to evaluate the performance of the proposed model through comparisons with the finite-element analysis (FEA) in Ansys. Simulation results reveal that the proposed model accurately estimates contact force, with an average error of around 3% and 4% for single or multiple node cases, respectively, regardless of various design parameters (Part I of this article is released in Arxiv1)

Published
2023

22. GPU-based ultra fast IMRT plan optimization

Author

Men, Chunhua, Gu, Xuejun, Choi, Dongju, Majumdar, Amitava, Zheng, Ziyi, Mueller, Klaus, and Jiang, Steve B.

Subjects
Physics - Medical Physics
Abstract

The widespread adoption of on-board volumetric imaging in cancer radiotherapy has stimulated research efforts to develop online adaptive radiotherapy techniques to handle the inter-fraction variation of the patient's geometry. Such efforts face major technical challenges to perform treatment planning in real-time. To overcome this challenge, we are developing a supercomputing online re-planning environment (SCORE) at the University of California San Diego (UCSD). As part of the SCORE project, this paper presents our work on the implementation of an intensity modulated radiation therapy (IMRT) optimization algorithm on graphics processing units (GPUs). We adopt a penalty-based quadratic optimization model, which is solved by using a gradient projection method with Armijo's line search rule. Our optimization algorithm has been implemented in CUDA for parallel GPU computing as well as in C for serial CPU computing for comparison purpose. A prostate IMRT case with various beamlet and voxel sizes was used to evaluate our implementation. On an NVIDIA Tesla C1060 GPU card, we have achieved speedup factors of 20-40 without losing accuracy, compared to the results from an Intel Xeon 2.27 GHz CPU. For a specific 9-field prostate IMRT case with 5x5 mm^2 beamlet size and 2.5x2.5x2.5 mm^3 voxel size, our GPU implementation takes only 2.8 seconds to generate an optimal IMRT plan. Our work has therefore solved a major problem in developing online re-planning technologies for adaptive radiotherapy., Comment: submitted to Physics in Medicine and Biology

Published
2009
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29. A 3D Sketching Interacting Tool for Physical Simulation Based on Web

Author

Zheng, Ziyi, Sun, Lingyun, Sun, Shouqian, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Jacko, Julie A., editor

Published
2007
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31. A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia.

Author

Yi, Tingting, Wang, Na, Huang, Jing, Wang, Yaling, Ren, Shuancheng, Hu, Yiwen, Xia, Jianxia, Liao, Yixiang, Li, Xin, Luo, Fenlan, Ouyang, Qin, Li, Yu, Zheng, Ziyi, Xiao, Qin, Ren, Rong, Yao, Zhongxiang, Tang, Xiangdong, Wang, Yanjiang, Chen, Xiaowei, and He, Chao

Subjects
GHRELIN receptors, SEVOFLURANE, MESENCEPHALON, ANESTHESIA
Abstract

Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia. [ABSTRACT FROM AUTHOR]

Published
2023
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38. P-64: Research for Large Size Reflective LCDs

Author

Yuan Shuai, Liu Xiaona, Ming Zhu, Jiazuo Sai, Zheng Ziyi, Chen Weitao, Chen Yuqiong, Qi Sang, Ma Yu, and Wang Mengjie

Subjects
010302 applied physics, Materials science, business.industry, 02 engineering and technology, Polarizer, 021001 nanoscience & nanotechnology, 01 natural sciences, Reflectivity, law.invention, Optics, law, 0103 physical sciences, 0210 nano-technology, business, Large size
Published
2018
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40. P-64: Research for Large Size Reflective LCDs

Author

Chen, Yuqiong, primary, Liu, Xiaona, additional, Zhu, Ming, additional, Sang, Qi, additional, Wang, Mengjie, additional, Yuan, Shuai, additional, Zheng, Ziyi, additional, Sai, Jiazuo, additional, Ma, Yu, additional, and Chen, Weitao, additional

Published
2018
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50. A 3D Sketching Interacting Tool for Physical Simulation Based on Web.

Author

Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Jacko, Julie A., Zheng, Ziyi, Sun, Lingyun, and Sun, Shouqian

Abstract

Sketching interface, as a user-friendly means for expression and communication, is not only an important medium for inputting 3D objects, but also a significant step of visualizing user's conceptual ideas. To bring early sketching interface to network utilities, the paper defines several rules that can create and edit 3D models. These gesture schemes support both regular and freeform modeling, and can be embedded in multi-user interface through network. A brief introduction about sketch-based collaboration in client-server architecture is proposed. A tool with this sketch interface and physical simulation functionalities is presented. The experimental results show that it can explore users' ideas in aiding 3D collaboration in network environment. [ABSTRACT FROM AUTHOR]

Published
2007
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