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A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia.
- Source :
- Advanced Science; 5/26/2023, Vol. 10 Issue 15, p1-16, 16p
- Publication Year :
- 2023
-
Abstract
- Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia. [ABSTRACT FROM AUTHOR]
- Subjects :
- GHRELIN receptors
SEVOFLURANE
MESENCEPHALON
ANESTHESIA
Subjects
Details
- Language :
- English
- ISSN :
- 21983844
- Volume :
- 10
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- Advanced Science
- Publication Type :
- Academic Journal
- Accession number :
- 163949730
- Full Text :
- https://doi.org/10.1002/advs.202300189