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A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia.

Authors :
Yi, Tingting
Wang, Na
Huang, Jing
Wang, Yaling
Ren, Shuancheng
Hu, Yiwen
Xia, Jianxia
Liao, Yixiang
Li, Xin
Luo, Fenlan
Ouyang, Qin
Li, Yu
Zheng, Ziyi
Xiao, Qin
Ren, Rong
Yao, Zhongxiang
Tang, Xiangdong
Wang, Yanjiang
Chen, Xiaowei
He, Chao
Source :
Advanced Science; 5/26/2023, Vol. 10 Issue 15, p1-16, 16p
Publication Year :
2023

Abstract

Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21983844
Volume :
10
Issue :
15
Database :
Complementary Index
Journal :
Advanced Science
Publication Type :
Academic Journal
Accession number :
163949730
Full Text :
https://doi.org/10.1002/advs.202300189