72 results on '"Z, Jouhadi"'
Search Results
2. Streptococcus intermedius : une cause rare d’abcès cérébral chez l’enfant
- Author
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Z. Jouhadi, J. Najib, I. Hafid, and H. Sadiki
- Subjects
Pathology ,medicine.medical_specialty ,biology ,business.industry ,Streptococcus intermedius ,bacterial infections and mycoses ,medicine.disease ,biology.organism_classification ,Cerebrospinal fluid ,stomatognathic system ,Antibiotic therapy ,Pediatrics, Perinatology and Child Health ,medicine ,Streptococcus anginosus ,Abscess ,business ,Streptococcus milleri ,Brain abscess ,Pathogen - Abstract
Streptococcus intermedius is a member of the Streptococcus anginosus group, also known as the Streptococcus milleri group. Although this is a commensal agent of the mouth and upper airways, it has been recognized as an important pathogen in the formation of abscesses. However, it has rarely been involved in the formation of brain abscess in children. We report 4 pediatric cases of brain abscess caused by S. intermedius. Three boys and 1 girl, all aged over 2 years, were admitted for a febrile meningeal syndrome and seizures, caused by a S. intermedius brain abscess. Diagnosis was obtained by brain imaging combined with culture of cerebrospinal fluid. The outcome was favorable after antibiotic therapy and abscess puncture. S. intermedius should be considered a potential pathogen involved in the development of brain abscess in children.
- Published
- 2013
3. Meningites à streptocoque du groupe A
- Author
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J. Najib, Z. Honsali, H. Belabess, Khalid Zerouali, M. Lehlimi, Z. Jouhadi, N. Mdaghri, and H. Sadiki
- Subjects
Pediatrics ,medicine.medical_specialty ,medicine.drug_class ,Streptococcus ,business.industry ,Incidence (epidemiology) ,Cephalosporin ,Amoxicillin ,medicine.disease ,medicine.disease_cause ,Group A ,Infectious Diseases ,Concomitant ,medicine ,Risk factor ,business ,Meningitis ,medicine.drug - Abstract
An increased incidence and severity of invasive group A streptococcus (GAS) infections over the past decade have been reported by several authors, but GAS remains an uncommon cause of bacterial meningitis. The aim of this study was to describe and analyze the clinical and biological data of GAS meningitis by reporting 10 new cases of pediatric GAS meningitis and making a literature review. The mean age of patients, seven girls and three boys, was 3 years. There was a history of preexisting or concomitant community-acquired infection in five patients over 10. The outcome was fatal in two cases. All patients received an initial empirical antimicrobial therapy with a third generation cephalosporin switched in six cases to amoxicillin. The prognosis for this type of streptococcal meningitis is usually good, but death may occur even in children without any identified risk factor for severe infection.
- Published
- 2012
4. Epidemiological profile of invasive bacterial diseases in children in Casablanca, Morocco: antimicrobial susceptibilities and serotype distribution
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N. Jilali, S. Zaid, M. Lahssoune, N. El Mdaghri, Z. Jouhadi, and Houria Belabbes
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Male ,Serotype ,Neisseria meningitidis ,medicine.disease_cause ,Group B ,Microbiology ,Haemophilus influenzae ,Pneumococcal Vaccines ,Streptococcus pneumoniae ,medicine ,Humans ,Prospective Studies ,Serotyping ,business.industry ,Haemophilus influenzae type b ,Infant, Newborn ,Infant ,Drug Resistance, Microbial ,Bacterial Infections ,General Medicine ,medicine.disease ,Virology ,Anti-Bacterial Agents ,Penicillin ,Morocco ,Pneumonia ,Child, Preschool ,Female ,business ,Meningitis ,medicine.drug - Abstract
The aim of this prospective study in Morocco was to investigate the causes of invasive bacterial diseases in children in order to inform antibiotic therapy and vaccine choices. Of 238 children aged < or = 5 years admitted to the Children's Hospital of Casablanca for invasive diseases over a 12-month period, 185 were diagnosed with bacterial infection: 76 had chest-X-ray-confirmed pneumonia, 59 had meningitis and 50 had sepsis. Streptococcus pneumoniae was the most common pathogen identified (n = 24), followed by Neisseria meningitidis (n = 18, all group B) and Haemophilus influenzae (n = 11). The rate of penicillin non-susceptibility was 62.5% among Str. pneumoniae isolates and 11.1% among N. meningitidis and all isolates were ceftriaxone-susceptible. Of the 11 H. influenzae isolates, only 1 produced a beta-lactamase. The 5 predominant Str. pneumoniae serotypes were 19F, 14, 23F, 6B and 19A and the theoretical coverage of the 7, 10 and 13-valent pneumococcal conjugate vaccines was 60%, 78% and 91% respectively.
- Published
- 2012
5. Neuromyélite optique de Devic et hépatite virale A
- Author
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Mohammed Abdoh Rafai, I. Ouazzani, Z. Jouhadi, I. Slassi, B. El Moutawakil, and A. Abid
- Subjects
Neurology ,Neurology (clinical) - Abstract
Resume Introduction La neuromyelite optique de Devic (NMO) est une entite clinique rare qui associe une myelite transverse severe et une neuropathie optique unilaterale ou bilaterale. Son pronostic serait selon plusieurs auteurs meilleur chez l’enfant. Observation Les auteurs rapportent une observation de NMO chez un enfant de 8 ans, sans antecedents pathologiques, admis pour tetraplegie flasque et chute brutale de l’acuite visuelle. L’examen ophtalmologique montrait une neuropapillite bilaterale. L’IRM medullaire objectivait un aspect de myelite etendue avec archnoidite bifocale. La recherche d’un facteur infectieux declenchant revelait des IgM diriges contre l’hepatite virale A. L’evolution sous traitement par corticoides a ete marquee par une recuperation totale de la vision, une recuperation motrice et sensitive au niveau des membres superieurs et du tronc. L’enfant a garde une paraplegie avec des troubles sphincteriens. Conclusion A travers cette observation particuliere par le facteur declenchant (virus de l’hepatite A), les auteurs font une mise au point sur ce syndrome rare avec revue generale de l’ensemble des cas pediatriques publies dans la litterature.
- Published
- 2004
6. Kyste hydatique cardiaque
- Author
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A. Skalli, A. Abid, A. Hamdani, Z. Jouhadi, F. Ailal, N. Dreoua, and A. Zine Eddine
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Hydatid cyst ,General Medicine ,business ,medicine.disease ,Echinococcosis - Abstract
Resume Introduction Le diagnostic de kyste hydatique cardiaque est difficile en raison de l’absence de signes cliniques specifiques. Il s’agit d’une affection rare chez l’adulte, encore plus chez l’enfant. Observations Chez une enfant de 12 ans, operee d’un kyste hydatique pulmonaire droit 4 ans plus tot, est survenue une detresse respiratoire. Il s’agissait d’une insuffisance cardiaque droite secondaire a un cœur pulmonaire chronique post-embolie hydatique. Chez un enfant de 13 ans ayant une hydatidose pulmonaire (premiers signes cliniques 3 ans auparavant), l’echocardiographie a mis en evidence une image kystique multicloisonnee au niveau de la paroi anterieure de l’oreillette droite, avec une autre image similaire a la partie anterieure de l’infundibulum pulmonaire. Commentaires Ces observations illustrent la gravite possible des complications du kyste hydatique, parasitose endemique en Afrique du Nord (echinococcose pulmonaire metastatique et cœur pulmonaire chronique). L’imagerie est d’une grande importance pour le diagnostic precoce, le bilan lesionnel et le suivi apres traitement.
- Published
- 2004
7. Les salmonelloses non typhoïdiques chez l'enfant : à propos de 41 cas
- Author
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F. Ailal, F. Adnane, A. Abid, Z Jouhadi, and A. Bousfiha
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Gynecology ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,Sepsis mortality ,Salmonella enteritidis ,Medicine ,business ,Antibacterial agent - Abstract
Resume Les salmonelloses non typhoidiques constituent chez le nourrisson un facteur important de mortalite infantile dans les pays en voie de developpement. Objectif. – Nous avons voulu analyser le profil epidemioclinique, therapeutique et evolutif des salmonelloses non typhoiques au Maroc. Methode. – Etude retrospective de 41 cas, recenses dans le service de pediatrie de l'hopital d'enfants de Casablanca entre 1994 et 2002 Resultats. – Il s'agissait de 20 salmonelloses digestives, 16 septicemies et dix infections neuromeningees. Dix malades ont ete recenses dans le cadre d'une epidemie de creche a Salmonella typhimurium resistant. Cinquante pour cent des cas avaient moins de trois mois. Les trois malades âges de un a trois ans avaient un deficit immunitaire primitif. La fievre et les troubles digestifs etaient presents dans 97 % des cas, une diarrhee aigue liquidienne dans 89 % et une deshydratation aigue dans 55 %. Le germe etait isole dans le sang chez 25 malades, dans les selles chez dix malades et dans le LCR chez neuf malades. Les serotypes isoles etaient : S. typhimurium (53,6 %), Salmonella enteritidis (44 %) et Salmonella agona (1 cas). La resistance aux antibiotiques concernait surtout S. typhimurium (34 %) lors d'une epidemie de creche. L'evolution a ete favorable dans 80 %, mais deux cas de meningites ont evolue vers des sequelles neurologiques majeures. Six deces sont survenus dans des formes septicemiques chez des nourrissons hypotrophes de moins de trois mois.
- Published
- 2004
8. P-331 – Encéphalomyélite aigue disséminé (EMAD) révélé par une cécité bilatérale: à propos de 2 cas
- Author
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H. Ramadan, J. Najib, N. Amenzoui, M. Fouissi, F. Adnane, and Z. Jouhadi
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
9. P-347 – Tuberculose extra-pulmonaire de l'enfant à propos de 64 cas
- Author
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F. Adnane, Aziz Bousfiha, N. Amenzoui, Fatima Ailal, J. Najib, N. Ech-Charii, O. Nachar, and Z. Jouhadi
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
10. CO-34 – Les tuberculomes cérébraux à propos de 20 cas
- Author
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D. Bensabbahia, Z. Jouhadi, J. Najib, and K. Chbani
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
11. Abcès et empyèmes sous-duraux : complications inhabituelles des méningites à méningocoques : à propos de quatre observations pédiatriques
- Author
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N. Dreoua, J. Najib, N Daoud, A. Abid, A Touki, and Z Jouhadi
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biology ,business.industry ,Neisseria meningitidis ,medicine.disease ,biology.organism_classification ,Meningococcal disease ,medicine.disease_cause ,Empyema ,Microbiology ,Central nervous system disease ,Infectious Diseases ,medicine ,Neisseriaceae ,Abscess ,Complication ,business ,Meningitis - Published
- 2004
12. Fièvre typhoïde chez le nourrisson : à propos de trois observations
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Z Jouhadi, N Idrissi Slitine, J. Najib, F. Ailal, and A. Abid
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Infectious Diseases ,business.industry ,Medicine ,business - Published
- 2003
13. [Streptococcus intermedius: a rare cause of brain abscess in children]
- Author
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Z, Jouhadi, H, Sadiki, I, Hafid, and J, Najib
- Subjects
Male ,Adolescent ,Child, Preschool ,Streptococcal Infections ,Brain Abscess ,Humans ,Female ,Streptococcus intermedius ,Child - Abstract
Streptococcus intermedius is a member of the Streptococcus anginosus group, also known as the Streptococcus milleri group. Although this is a commensal agent of the mouth and upper airways, it has been recognized as an important pathogen in the formation of abscesses. However, it has rarely been involved in the formation of brain abscess in children. We report 4 pediatric cases of brain abscess caused by S. intermedius. Three boys and 1 girl, all aged over 2 years, were admitted for a febrile meningeal syndrome and seizures, caused by a S. intermedius brain abscess. Diagnosis was obtained by brain imaging combined with culture of cerebrospinal fluid. The outcome was favorable after antibiotic therapy and abscess puncture. S. intermedius should be considered a potential pathogen involved in the development of brain abscess in children.
- Published
- 2012
14. [Group A streptococcal meningitis]
- Author
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Z, Jouhadi, H, Sadiki, M, Lehlimi, Z, Honsali, J, Najib, K, Zerouali, H, Belabess, and N, Mdaghri
- Subjects
Male ,Cross Infection ,Streptococcus pyogenes ,Incidence ,Infant, Newborn ,Amoxicillin ,Infant ,Cephalosporins ,Meningitis, Bacterial ,Community-Acquired Infections ,Hospitals, University ,Morocco ,Postoperative Complications ,Child, Preschool ,Streptococcal Infections ,Humans ,Ampicillin ,Female - Abstract
An increased incidence and severity of invasive group A streptococcus (GAS) infections over the past decade have been reported by several authors, but GAS remains an uncommon cause of bacterial meningitis. The aim of this study was to describe and analyze the clinical and biological data of GAS meningitis by reporting 10 new cases of pediatric GAS meningitis and making a literature review. The mean age of patients, seven girls and three boys, was 3 years. There was a history of preexisting or concomitant community-acquired infection in five patients over 10. The outcome was fatal in two cases. All patients received an initial empirical antimicrobial therapy with a third generation cephalosporin switched in six cases to amoxicillin. The prognosis for this type of streptococcal meningitis is usually good, but death may occur even in children without any identified risk factor for severe infection.
- Published
- 2012
15. P-113 – Fièvre aigue isolée des nourrissons de 3 à 36 mois: quelles étiologies?
- Author
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F. Adnane, J. Najib, N. Ech-Charii, N. Amenzoui, G. Benbrahim, Z. Jouhadi, Aziz Bousfiha, and Fatima Ailal
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
16. P-105 – Localisations inhabituelles de la tuberculose ostéo-articulaire chez l'enfant
- Author
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S. Salam, J. Najib, Z. Jouhadi, N. Douail, L. Ouzidane, K. Chbani, and K. Aitidir
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
17. P-101 – Tuberculose hépatique à propos de 3 cas
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S. Labied, K. Chbani, D. Bensabbahia, J. Najib, and Z. Jouhadi
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
18. P-115 – Déficit en protéines du complément au cours des méningites purulentes
- Author
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L. Lekhyar, N. Amenzoui, M. El Alaoui, Z. Jouhadi, J. Najib, Aziz Bousfiha, F. Adnane, and Fatima Ailal
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
19. P-110 – Complications neurologiques dans la varicelle grave: quels facteurs de risque?
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Aziz Bousfiha, Fatima Ailal, Z. Jouhadi, N. Amenzoui, G. Benbrahim, N. Ech-Charii, F. Adnane, and J. Najib
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
20. P-479 – Maladie de Kawasaki révélée par un syndrome méningé
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I. Belhsaine, S. Atiki, N. Amenzoui, Z. Jouhadi, J. Najib, F. Elmasbahi, and F. Adnane
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
21. P-530 – Utilité de la ponction lombaire lors des convulsions fébriles chez le nourrisson moins de 18 mois: à propos de 422 cas
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N. Amenzoui, Z. Jouhadi, J. Najib, F. Adnane, Aziz Bousfiha, Fatima Ailal, K. Ait Idir, and N. Ech-Charii
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2015
22. P-096 – Épidémiologie de l'infection urinaire sur terrain d'uropathies malformatives
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N. Jilali, F. Masebahi, S. Bassit, Z. Jouhadi, and N. Mikou
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Pediatrics, Perinatology and Child Health - Published
- 2015
23. [Forty-one pediatric cases of non-typhoidal salmonellosis]
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F, Ailal, A A, Bousfiha, Z, Jouhadi, F, Adnane, and A, Abid
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Male ,Salmonella typhimurium ,Inpatients ,Urban Population ,Immunologic Deficiency Syndromes ,Infant ,Child Day Care Centers ,Comorbidity ,Hospitals, Pediatric ,Disease Outbreaks ,Failure to Thrive ,Gastroenteritis ,Meningitis, Bacterial ,Morocco ,Salmonella enteritidis ,Child, Preschool ,Drug Resistance, Multiple, Bacterial ,Sepsis ,Diarrhea, Infantile ,Salmonella Infections ,Humans ,Female ,Seasons ,Child ,Retrospective Studies - Abstract
Non-typhoidal Salmonella (NTS) infections are a major cause of infantile death in developing countries.The aim of this study was to determine the epidemiologic and therapeutic data, as well as the evolution of NTS in Morocco.This retrospective study was made on 41 patients hospitalized for NTS between 1994 and 2002 in the Casablanca University Hospital Pediatric ward.Twenty cases of digestive salmonellosis were diagnosed, 16 cases of septicemia, and 10 cases of meningitis. Ten patients were hospitalized after an outbreak of resistant Salmonella typhimurium in a nursery. Fifty percent of the patients were less than 3 months of age. The three patients between 1 and 3 years of age presented with primary immunodeficiency. Fever, vomiting, and diarrhea were noted in 97% of the cases. The stools were watery in 89% and severe dehydration in 55% of the cases. Salmonella strains were identified in blood in 25 cases, from stools in 10 cases, and from CSF in nine cases. The following Salmonella serotypes were identified: S. typhimurium (53.6%), S. enteritidis (44%), and S. agona (2.4%). Resistance to antibiotics was noted, especially for Salmonella typhimurium (34%) in the nursery outbreak. The evolution was favorable in 80%, but two children with meningitis developed severe neurological sequels, and six hypotrophic infants under 3 years of age died after septicemia.
- Published
- 2005
24. [Orbital cellulitis in children: a retrospective study of 33]
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F, Ailal, A, Bousfiha, Z, Jouhadi, M, Bennani, and A, Abid
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Male ,Child, Preschool ,Orbital Diseases ,Humans ,Cellulitis ,Female ,Child ,Retrospective Studies - Abstract
Orbital cellulitis is rare. However the high risk of severe ocular and neurological complications make early diagnosis and adequate therapy essential. The purpose of this retrospective study is to describe 33 cases observed in the pediatric infectious disease department of the Casablanca Children's Hospital in Morocco from 1994 to 2000. Orbital cellulitis was preseptal in 24 patients and retroseptal in 9. Infection occurred in relation with sinusitis in 10 cases, polydermitis in 8, wound infection in 6, ocular infection in 2, and dental abscess in 2. Ages ranged from 40 days to 15 years with a mean age of 5 years. Infants accounted for 25% of cases and always presented preseptal cellulitis. Fever and local edema were noted in all patients. Exophthalmia occurred in six patients and seizures in 2. The 9 cases of retroseptal cellulitis were complicated by empyema in 2 cases, meningitis in 1 case and thrombophlebitis of cavernous sinus with cerebromalacia in 1 case. Bacteriological testing identified micro-organisms in 10 cases, i.e., Staphylococcus aureus in 6 cases, Streptococcus B in 1, Streptococcus pyogenes in 1, Enterobacter Cloacae in land Acinitobacter jejuni in 1 case. Therapy was based on broad-spectrum antibiotics in association with surgery in the patient presenting in intracranial abscess. Ophthalmoplegia-like sequels including blindness, aphasia, and motor deficit occurred in 2 patients. Orbital cellulitis in children are usually preseptal and have a favorable prognosis. However prompt and adequate antibiotherapy is essential due to the risk of retroseptal involvement with inflammatory palpberal edema and possible cerebral extension.
- Published
- 2004
25. [Sub-dural abscess and empyema: unusual complications of meningococcal meningitis: four paediatric cases]
- Author
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Z, Jouhadi, A, Touki, N, Dreoua, N, Daoud, J, Najib, and A, Abid
- Subjects
Male ,Empyema, Subdural ,Child, Preschool ,Brain Abscess ,Humans ,Infant ,Female ,Meningitis, Meningococcal - Published
- 2004
26. [Cardiac hydatid cyst. Two cases in children]
- Author
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Z, Jouhadi, F, Ailal, N, Dreoua, A Zine, Eddine, A, Abid, A, Skalli, and A, Hamdant
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Diagnosis, Differential ,Male ,Dyspnea ,Adolescent ,Heart Diseases ,Echinococcosis ,Echocardiography ,Humans ,Female ,Child - Abstract
Diagnosis of a cardiac hydatid cyst is difficult because of the absence of specific clinical signs. This is a rare disease in adults, but even rarer in children.In a 12 year-old girl, operated on for a pulmonary hyatid cyst 4 years earlier, respiratory distress appeared. This was caused by right heart failure secondary to a chronic hyatid post-embolus pulmonary heart. In a 13 year-old boy exhibiting pulmonary hydatosis (first clinical signs 3 years earlier) echocardiography revealed a multi-compartmented cystic image of the anterior wall of the left atrium, with another similar image in the anterior section of the pulmonary infundibulum.These observations illustrate the potential gravity of complications of a hydatid cyst, endemic parasitosis in North Africa (metastatic pulmonary echinococcosis and chronic pulmonary heart). Imaging is crucial for the early diagnosis, assessment of the lesions and follow-up after treatment.
- Published
- 2004
27. [Devic's optic neuromyelitis and viral hepatitis type A. A paediatric case report]
- Author
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Z, Jouhadi, I, Ouazzani, A, Abid, B, El Moutawakil, M A, Rafai, and I, Slassi
- Subjects
Male ,Neuromyelitis Optica ,Humans ,Hepatitis A ,Child - Abstract
Devic optic neuromyelitis is a rare clinical disease that involves severe transverse myelitis and unilateral or bilateral optic neuropathy. Its pathogenesis would be explained by demyelinization triggered by bacterial or viral infections phenomena. According to several author, prognosis would be better in children.We report a case of optic neuromyelitis in an 8-year-old child with an uneventful history who was admitted because he suffered from flaccid tetraplegia and sudden decline of the visual acuity. The ophthalmologic examination revealed bilateral neuropapillitis. The medullary MRI visualized a spreading myelitis with bifocal arachnoiditis. Search for a precipitating infectious factor showed positive IgM for viral hepatitis A. With corticosteroid treatment the child achieved total recovery of vision and recovered motor and sensorial function of the upper limbs and the trunk. Paraplegia with sphincteral disorders persisted.This case characterized by the precipitating factor (hepatitis virus A), illustrates this rare syndrome. We present a general review of the pediatric cases reported in the literature.
- Published
- 2004
28. SFP P-120 – Les méningites bactériennes communautaires de l’enfant entre 2009 et 2012
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Khalid Zerouali, M. Ghamraoui, Z. Jouhadi, and J. Najib
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
Objectif du travail : decrire le profil epidemiologique, clinico-bacteriologique et evolutif des meningites bacteriennes notamment apres introduction du vaccin anti-pneumococcique. Materiel et methodes : il s’agit d’une etude retrospective de 245 cas colliges a l’hopital d’enfant de Casablanca entre janvier 2009 et decembre 2012. Resultats: Nos patients etaient âges entre 1mois et 14ans. 73% d’entre eux etaient âges de moins de 5 ans. L’agent causal a ete identifie dans 49,8% des cas ; Neisseria meningitidis(NM) en a represente63,9% des cas suivi du Streptococcus pneumonia(SP) avec 19.6% des cas. Les bacilles Gram negatif ont represente 7,3% des cas et Haemophilus influenza(Hib) 4,9%. La sensibilite a ete testee chez 17cas de SP dont 47% etait resistants. Avant 2012, les serogroupes 19, 23, 14 et 6 ont represente 60% des SP. En 2013.18,36% des meningites se sont compliquees. Le pneumocoque etait le plus pourvoyeur de complications avec une nette predominance des complications suppuratives (14,6% des complications). Le taux de mortalite a atteint seulement 2% des cas. Conclusion :Cette etude permet de discuter l’impact de la vaccination sur le profil bacteriologique des meningites purulente et souligne l’urgence de l’introduction du vaccin anti NM au Maroc.
- Published
- 2014
29. SFP P-009 - Le syndrome d’hyperimmunoglobulinémie E associé à un lupus systémique
- Author
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J. Najib, Z. Jouhadi, R. Atlas, K. Bouayad, and F. Hassan
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Pediatrics, Perinatology and Child Health - Abstract
Le syndrome d’hyperIgE est un deficit immunitaire primitif rare qui se manifeste par des infections recidivantes et severes, des lesions eczematiformes et une elevation du taux serique des IgE(sup a 2000UI/ml) avec une hypereosinophilie. Ce terrain favoriserait l’apparition de troubles dysimmunitaires. Nous rapportons un syndrome hyperIgE associe a un lupus systemique; association rare voire exceptionnelle et qui semble a notre connaissance le sixieme cas rapporte dans la litterature. Une fille de 8 ans, issue d’un mariage consanguin 3eme degre, suivie pour syndrome hyperIgE depuis la petite enfance qui a developpe au cours de l’evolution un lupus systemique retenu devant des lesions cutanees purpuriques et necrotiques du visage, une arthrite des coudes et des interphalangiennes distales et proximales, une glomerulonephrite stadeII, avec une lymphopenie a 1920elts/mm 3 et des AAN, anti-DNA natif et APL positifs. Cette association pose des difficultes; l’utilisation des immunosuppresseurs au cours du lupus peut aggraver l’immunodepression deja existante. Notre malade a ete traitee par corticotherapie generale avec une bonne evolution. Malgre que la physiopathogenie de cette association reste obscure, notre cas peut etre pris comme une preuve supplementaire de ces liens complexes.
- Published
- 2014
30. P467 - Les tuberculomes intracérébraux, à propos de 11 cas
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Z. Jouhadi, M. Lahlimi, J. Najib, and F. Ait Lahsine
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
Le Tuberculome intracerebral est la deuxieme expression de la tuberculose du systeme nerveux central. Bien que rare, cette pathologie n’epargne aucun âge.Le diagnostic est evoque devant l’association de donnees anamnestiques, epidemiologiques, cliniques et radiologiques. Le but de notre travail est de preciser les aspects cliniques,radiologiques et evolutifs du tuberculome intracerebral.L’âge moyen est de six ans. Tous nos malades vaccines au BCG avec notion de contage tuberculeux chez 6.Un syndrome d’hypertension intracrânienne retrouve dans 10 cas avec un syndrome meninge dans 8 cas, un deficit moteur dans 8 cas, des troubles de conscience dans 6 cas et des convulsions dans 2 cas La ponction lombaire avait montre une meningite lymphocytaire dans tous les cas. La TDM avait objective un aspect de tuberculome associe a une hydrocephalie. Tous nos malades ont recu des antibacillaires associes a des corticoides et derivation ventriculoperitoneale dans 8 cas. L’evolution etait favorable dans 5 cas avec deficit moteur dans 4 cas et sequelles sensorielles dans 2 cas. La tuberculose est un probleme de sante publique responsable d’une morbimortalite elevee. Le tuberculome expose a des sequelles neurologiques. La prevention passe par la vaccination, le depistage et l’education sanitaire.
- Published
- 2010
31. [Gastrointestinal myiasis. Apropos of 1 Moroccan case]
- Author
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A, Abkari, Z, Jouhadi, A, Hamdani, N, Mikou, N, Guessous, and H H, Khalifa
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Morocco ,Myiasis ,Adolescent ,Gastrointestinal Diseases ,Diptera ,Larva ,Animals ,Humans ,Female ,Abdominal Pain - Abstract
This observation relates an exceptional case of gastrointestinal myiasis in a 15 year-old rural Moroccan girl. She was admitted for abdominal pain, hematemesis, and worm vomitting. The parasitologic identification revealed Sarcophaga hemorrhoidalis. Through this observation, the authors underline the epidemiological, clinical and evolutive aspects of this parasitosis in Morocco.
- Published
- 1999
32. SFP-P062 – Pathologie infectieuse – Fièvre prolongée chez l’enfant (à propos de 82 cas)
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I. Benhsaien, J. Najib, M. Laraki, and Z. Jouhadi
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
La fievre est un signe d’appel frequent en pathologie infantile, elle represente 0.3 % a 4 % des hospitalisations pediatriques. Elle est dite prolongee lorsqu’elle dure au moins 7j chez l’enfant et 5j chez le nourrisson. Une fievre prolongee est d’origine inconnue lorsqu’elle demeure sans cause connue apres une semaine d’investigations a l’hopital. Le but de notre travail est de preciser le profil epidemiologique et etiologique des fievres prolongees chez l’enfant. Il s’agit d’une etude retrospective portant sur 82 dossiers de fievres prolongees colliges au service de maladies infectieuses pediatriques du CHU de Casablanca (Pediatrie I) sur une periode de 7 ans de Janvier 2000 a Decembre 2006. Il s’agit de 53 garcons et 29 filles âges en moyenne de 5 ans. Le delai moyen d’admission par rapport au debut de la fievre etait de 24,5 jours. Les etiologies infectieuses ont ete preponderantes : 56 % dominees par la tuberculose dans 6 cas ; suivi de maladies inflammatoires dans 20 cas (24 %) avec comme chef de fil la maladie de Kawasaki dans 13 cas et en dernier les hemopathies dans 4 cas (4 %). Aucune etiologie n’a ete retrouvee dans 15 cas (6,4 %). L’evolution a ete favourable dans 74 cas soit 90,2 %. Nous avons eu 9 deces (9,7 %). Les fievres prolongees de l’enfant posent un probleme d’ordre etiologique. La plupart des retards diagnostiques sont le fait d’un interrogatoire et/ou d’un examen clinique incomplet, ou insuffisamment repete. Or la clinique est une etape fondamentale dans l’orientation et la hierarchisation des examens complementaires. Les formes atypiques des maladies frequentes sont le plus souvent en cause plutot que les maladies rares. Aucune cause n’est retrouvee dans 10 a 20 % des cas. Enfin nous insistons sur la necessite d’une conduite diagnostique et therapeutique coherente devant une fievre prolongee de l’enfant.
- Published
- 2008
33. Cellulite cervico-faciale de l’enfant (à propos de 25 cas)
- Author
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F. Ailal, F. Adnane, Z. Jouhadi, S. Tizki, N. Amenzoui, J. Najib, and A. Bousfiha
- Subjects
Otorhinolaryngology ,Surgery - Published
- 2012
34. 873 'Brain Abscess in Infants and Children: A Retrospective Study of 52 Patients in Pediatric's Hospital of Casablanca, Morocco
- Author
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Z Jouhadi, A Rachid, J Najib, and M. Lahlimi
- Subjects
Pediatrics ,medicine.medical_specialty ,Heart disease ,biology ,business.industry ,Retrospective cohort study ,Disease ,Streptococcus intermedius ,medicine.disease ,biology.organism_classification ,Otitis ,Pediatrics, Perinatology and Child Health ,medicine ,Central nerve system ,medicine.symptom ,business ,Meningitis ,Brain abscess - Abstract
Brain abscess is a serious disease of the central nerve system, it’s a rare pathology in children; to review the clinical manifestation, and predisposing factors, causative organism and outcomes of brain abscess we conducted a descriptive retrospective study in children’s hospital of Casablanca in unit of infectious diseases. Fifty two infants and children with brain abscess admitted between 1998 a 2011 are retrospectively analyzed. The mean age was 5, 6 years, 38% were aged less than 2 years. the male-to-female ratio was 0, 92. The most common predisposing factor was meningitis (29%); ORL causes (27%); otitis (17%) and congenital heart disease (11, 5%); the most common organisms are staphylococcus aureus; streptococcus intermedius and proteus mirabilis. Clinical manifestation were dominated by fever (79%); cranial hypertension (57%); seizures (36%) and motor deficiency in 35%, sequellae were constated in 36%; mortality in 4%. Brain abscesses result in significant morbidity and high fatality. Because brain abscesses can have subtle initial presentations, a high level of suspicion is very important for early diagnosis in pediatric patients, particularly those with underlying condition such as congenital heart disease.
- Published
- 2012
35. [Omentocele in abdominal wounds by knife stab]
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M, Kafih, Z, Jouhadi, H, Idrissi, M, Ridai, and O N, Zerouali
- Subjects
Laparotomy ,Humans ,Abdominal Injuries ,Wounds, Stab ,Omentum ,Hernia, Ventral ,Retrospective Studies - Published
- 1994
36. P482 - Les encéphalites virales aiguës de l’enfant (à propos de 30 cas)
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J. Najib, Z. Jouhadi, A. Harrak, and I. Benhsaien
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Pediatrics, Perinatology and Child Health - Abstract
Les encephalites virales aigues de l’enfant sont des infections non suppurees du parenchyme cerebral, rares et graves. Le virus le plus souvent incrimine est l’herpes. Leur pronostic depend essentiellement du virus causal. Le but de notre travail est de presenter une revue epidemiologique, clinique, paraclinique et evolutive. La moyenne d’âge est de 5 ans. Les crises convulsives febriles sont retrouvees chez 80 % des cas et 83 % presentent des troubles de conscience, 50 % de nos patients ont necessite des soins intensifs. Le diagnostic etiologique est pose chez 11 patients.7 patients ont eu des sequelles neurologiques apres un recul de 12 mois. Les encephalites virales aigues sont suspectees devant un tableau neurologique bruyant faits de crises epileptiques avec modification des fonctions cerebrales superieures, etat confusionnel et desorientation temporo-spatiale. Le diagnostic positif et etiologique a ete facilite grâce a l’utilisation de l’IRM, l’EEG, l’imagerie fonctionnelle, les serologies virales et la PCR surtout pour l’encephalite herpetique. L’evolution des enfants atteints d’encephalites virale est tres variable, environ 20 a 40 % gardent des sequelles neurosensorielles necessitant une prise en charge precoce pour ameliorer le devenir.
- Published
- 2010
37. P155 - Les pneumopathies atypiques chez l’enfant
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B. Takourt, L. Ibrahimi, Z. Jouhadi, I. Benhsaien, A. Harrak, and H. Fellah
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Pediatrics, Perinatology and Child Health - Abstract
Les pneumopathies atypiques sont dues a des germes viraux ou bacteriens. L’objectif de ce travail est de determiner la prevalence des principaux germes en cause a travers la serologie IgM et IgG. Materiels et Methodes Il s’agit d’une etude prospective transversale «preliminaire» etalee sur 4 mois. 30 serums d’enfants hospitalises pour des infection respiratoire etaient testes a la recherche des IgM et Ig G anti differents germes (Mycoplasma Pneumoniae, Chlamydia Pneumoniae, Legionella pneumophila, Coxiella burnittii, Adenovirus, Virus respiratoire syncytial, Influenza A et B et Parainfluenza serogroupe1) par la technique d’immunofluorescence indirecte. Resultats 70 % des serums testes sont positifs en Ig G et/ou Ig M pour au moins un germe alors que 30 % ne presentaient aucun marqueurs serologiques pour les differents germes recherches. Coxiella burnetti (CB) represente 30 % suivi de Mycoplasme Pneumoniae (MP) et Chlamydia Pneumoniae (CP) avec respectivement 20 % et 16 %. Conclusion CB, MP et CP semblent etre les principaux germes en causes des pneumopathies atypiques chez les enfants etudies. Les agents viraux predominent chez les enfants âges de moins de 3 ans alors que les bacteriens sont majoritaires chez les enfants plus de 3 ans.
- Published
- 2010
38. P147 - Les dilatations des bronches chez l’enfant
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I. Benhssain, F. Ailal, N. Amenzoui, J. Najib, Z. Jouhadi, A. Maltof, F. Adnane, and A. Bousfiha
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
Les dilatations des bronches (DDB) se manifestent par un tableau clinique et scannographique evocateurs. Elle est souvent secondaire a une maladie generale. L’objectif de notre travail est d’eclaircir le profil epidemiologique, clinique, paraclinique, etiologique, therapeutique et evolutif de cette affection. C’est une etude retrospective incluant 100 cas de DDB colliges dans notre service sur une periode de 10 ans. L’âge moyen de nos patients est de 7,78 ans sans predominance de sexe. Les symptomes etaient domines par la toux chronique, la bronchorrhee et l’hemoptysie. Le retentissement se manifestait surtout par un retard staturo-ponderal, l’hippocratisme digital et la deformation thoracique. L’etiologie etait le deficit immunitaire primitif dans 28 % des cas et restait indeterminee dans 46 % des cas. Tous nos patients avaient recu une antibiotherapie et une kinesitherapie respiratoire. La chirurgie etait realisee chez 14 cas. L’evolution etait marquee par la stabilisation (27 %), l’extension des lesions (37 %), le deces (8 %) et la survenue de complications (44 %). La bronchectasie constitue une cause de morbidite et de mortalite considerable en pediatrie. La prevention est fondamentale, elle repose sur une bonne vaccination et une prise en charge precoce et adequate.
- Published
- 2010
39. SFP-P200 – Pathologie infectieuse – Les méningites bactériennes chez l’enfant : étude prospective de 85 cas
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J. Najib, M. Lahlimi, F. Ailal, N. Mdaghri, Houria Belabbes, Z. Jouhadi, A. Harrak, and F. Adnane
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Pediatrics, Perinatology and Child Health - Abstract
Resume La meningite bacterienne est une affection grave constituant une cause de mortalite et de morbidite importante. Le taux d’incidence est eleve, representant un vrai probleme de sante public au Maroc. Les auteurs se proposent de determiner le profil epidemiologique, clinique, therapeutique et evolutif des meningites purulentes des meningites purulentes hospitalisees au CHU de Casablanca au cours de l’annee 2007. Nous rapportons une etude prospective portant sur 85 cas de meningitis purulentes chez l’enfant enfants menee au service de pediatrie infectieuse du CHU des enfants de Casablanca sur une periode de 1 an (Janvier2007–Decembre 2007). L’age moyen etait de 7,7 ans avec un sexe ratio de 1,5. L’affection sevit toute l’annee avec une recrudescence les 4 premiers mois de l’annee. Le delai de consultation etait de 3,9 jours. Le vaccin anti-hemophilus a ete administre chez 4 patients. Le tableau clinique etait domine par la fievre et les signes neurologiques. La raideur de la nuque a ete retrouvee dans 60 % des cas le purpura dans 25,8 % des cas. La ponction lombaire realisee chez 97,6 % des cas (82 cas) a retire un liquide louche ou trouble dans 80,3 % des cas ; clair dans 6,4 % des cas, hematique dans 6 %. La pleiocytose etait dominee par les PNN dans 97,6 % des cas. Le germe responsable a ete identifie dans 64,4 % des cas (51 cas). (Pneumocoque 13,25 % des cas, Hemophilus influenzae 14 % des cas, Meningocoque B 25,3 % des cas et meningocoque W135 dans un cas). L’antibiotique de premiere intention etait essentiellement a base Ceftriaxone (91,7 % des cas) (77 cas), Penicilline A dans 7 % des cas (5 cas), Ceftriaxone + Vancomycine dans 2 cas. L’evolution initiale etait favorable dans 69,4 % des cas (58 cas). Les complications ont ete notees dans 20 % des cas (17 cas) avec un taux de deces de 4,7 %. Les auteurs discutent ces resultats en fonction des donnees de la litterature, et soulignent l’importance de ces resultats appeles a etre profondement modifies du fait de l’integration du vaccin anti HIB au programme national d’immunisation en janvier 2007.
- Published
- 2008
40. SFP-P196 – Pathologie infectieuse – L’infection urinaire du nourrisson : étude rétrospective à propos de 100 cas
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H. Samlak, F. Ailal, Khalid Zerouali, J. Najib, Z. Jouhadi, and N. Mdaghri
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
L’infection urinaire (IU) est une pathologie frequente en pediatrie et continue a poser des difficultes diagnostiques et de suivi surtout chez le nourrisson. L’objectif de ce travail est de tracer le profil epidemio-clinique et bacteriologique des premiers episodes d’IU et de determiner la rentabilite des explorations radiologiques systematiques. Nous rapportons une etude retrospective de 100 cas ; menee sur une periode d’une annee du 1er janvier au 31 decembre 2006 ; Les dossiers retenus etaient ceux des nourrissons (30 j – 24 mois) hospitalises pour un premier episode d’infection urinaire ; confirmee par un examen cytobacteriologique des urines (ECBU) comportant une leucocyturie significative (superieure a 104 germes/ml) ± la presence d’un germe pathogene. Notre serie comporte 55 filles et 45 garcons. L’âge moyen est de 8 mois. Le motif d’hospitalisation etait une fievre aigue sans orientation clinique dans 43 cas (FASOC), une convulsion febrile dans 14 cas et une fievre prolongee dans 13 cas, 30 patients avaient presente des signes digestifs a type de douleur abdominale, diarrhee et/ou vomissement alimentaires dont 7 etaient en etat septique et 6 presentaient une deshydratation aigue tableau « C ». Sur le plan biologique tous les malades avaient une CRP positive (moyenne de 103,2 mg/l), et une hyperleucocytose moyenne 19743/mm3. Nous avons note 27 % de leucocyturie sans germe. Les germes isoles etaient l’Escherichia coli dans 55 cas (75,34 %), le Klebsiella pneumoniae dans 10 cas (13,7 %) ; le Proteus mirabilis dans 6 cas (8,2 %) et le staphylocoque aureus dans 2,7 %. Tous les germes etaient sensibles aux cephalosporines de 3 e generation (C3G) et aux aminosides, cependant 61,64 % etaient resistants a la penicillineA ; 39,72 % l’etaient a l’association amoxicilline + acide clavulanique 35,61 % au cotrimoxazol. 58 % ont ete traites par ceftriaxone-aminoside et (42 %) par la ceftriaxone. Une echographie renale systematique chez tous nos patients a montre une dilatation pyelocalicielle dans 18 %. La cystographie retrograde a ete realisee chez 14 patients et a revele un RVU grade 3-4 dans 2 cas.
- Published
- 2008
41. Méningite à Salmonella. A propos de 4 cas
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A. Zineddine, Z Jouhadi, J. Najib, A. Abid, and M. Bouskraoui
- Subjects
medicine.medical_specialty ,Salmonella ,medicine.diagnostic_test ,business.industry ,Salmonella enteritidis ,Mortality rate ,Amoxicillin ,medicine.disease_cause ,medicine.disease ,Gastroenterology ,Surgery ,Central nervous system disease ,Infectious Diseases ,Internal medicine ,medicine ,Blood culture ,business ,Meningitis ,medicine.drug - Abstract
Summary Meningitis due to Salmonella are still rare. 4 cases in children 2 to 5 months of age are reported. Salmonella enteritidis was isolated in CSF for all patients and twice in blood culture. Resistance to amoxicillin was noted once. Short and long terme evolution has been positive for all patients, which is unusual according to other reported cases with a high mortality rate and serious neurologic disorders.
- Published
- 1997
42. Etude epidemioclinique de la lal a propos de 33 enfants marocains
- Author
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Z. Jouhadi, H. Hadjkhalifa, A.A. Bousfihe, and J. Hachim
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 1996
43. Le caryotype dans les syndromes de fragilite chromosomique
- Author
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A. Benslimane, M. Chadli, A. A. Bousfiha, H. Hadj Khalifa, N. Hda, and Z. Jouhadi
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 1996
44. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID-19 Infection in Morocco.
- Author
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Amenzoui N, Zouiter S, Nassid M, Kholaiq H, Belkhou I, Benhsaien I, Ailal F, Adnane F, Jouhadi Z, and Bousfiha AA
- Abstract
Introduction . This study aims to describe the clinical and paraclinical characteristics of Multisysteminflammatory syndrome in children (MIS-C). Methods . A retrospective study encompassing 52 children diagnosed with MIS-C according to the World Health Organization criteria, over a 3-year period at Abderrahim Harrouchi Hospital in Morocco. Results . The median age was 6 years (IQR: 1-14), with a sex ratio of 1.16 (28 boys and 24 girls). Clinical manifestations were predominantly characterized by fever in all cases (100%), respiratory and gastrointestinal symptoms in 30 cases (58%) and 23 cases (44%) respectively, and shock in 9 cases (17%). We noted a myocarditis in 6 cases (12%). The treatment comprised intravenous human Immunoglobulin combined with methylprednisolone in all patients (100%). Conclusion . The characteristics of our MIS-C patients were similar to those in the literature, but more studies are needed to confirm these results., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)
- Published
- 2024
- Full Text
- View/download PDF
45. Lead in umbilical cord blood and associated factors in Casablanca Morocco: A preliminary results.
- Author
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Rouzi L, El-Hamri H, Cherkani-Hassani A, Benbounou N, El Kari K, Bouhya S, Aguenaou H, Jouhadi Z, and Fekhaoui M
- Subjects
- Humans, Morocco, Female, Adult, Pregnancy, Infant, Newborn, Male, Young Adult, Risk Factors, Lead blood, Fetal Blood chemistry
- Abstract
Background: Lead is the most common toxic metal to which Moroccans are exposed. Given the susceptibility of the fetus to lead, it is crucial to assess prenatal lead exposure. However, in Morocco, no study has assessed prenatal exposure to lead. The main goals of the present study are to determine lead concentration in umbilical cord blood and identify risk factors for prenatal lead exposure in Casablanca, Morocco., Methods: To achieve these purposes, 87 cord blood lead samples were collected from mothers-baby pairs from January to December 2019. Indeed, a structured questionnaire was used to collect socio-demographic characteristics, obstetric data, leisure, cultural habits, and environmental information. Cord blood lead level was analyzed by inductively coupled plasma-mass spectrometry., Results: The median lead concentration was 4.902 µg/dl with a minimum and maximum of 0.833 µg/dl and 23.593 µg/dl, respectively. A high proportion of the newborns (65.52 %) had cord blood lead levels above the Centers for Disease Control (CDC) allowable threshold limit (3.5 µg/dl). Statistical analysis was performed to assess the association between blood levels and the above factors. Lead levels in cord blood were significantly associated with the maternal educational level, anemia history, delivery mode, passive smoking during pregnancy as well as with the frequency of consumption of tea., Conclusion: This study provides the first data on lead levels in newborns. Cord blood lead levels were high in the majority of the participants, these results reinforce the need to establish health surveillance programs in Morocco., Competing Interests: Declaration of Competing Interest None., (Copyright © 2024 Elsevier GmbH. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
46. OTULIN-related conditions: Report of a new case and review of the literature using GenIA.
- Author
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Caballero-Oteyza A, Crisponi L, Peng XP, Wang H, Mrovecova P, Olla S, Siguri C, Marnissi F, Jouhadi Z, Aksentijevich I, Grimbacher B, and Proietti M
- Subjects
- Humans, Infant, Male, Female, Endopeptidases, Mutation, Missense genetics
- Abstract
OTULIN encodes an eponymous linear deubiquitinase (DUB) essential for controlling inflammation as a negative regulator of the canonical NF-κB signaling pathway via the regulation of M1-Ub dynamics. Biallelic loss-of-function (LOF) mutations in OTULIN cause an autosomal recessive condition named Otulin-Related Autoinflammatory Syndrome (ORAS), also known as Otulipenia or AutoInflammation, Panniculitis, and Dermatosis Syndrome (AIPDS). Monoallelic OTULIN LOF, also known as OTULIN Haploinsufficiency (OHI) or Immunodeficiency 107 (IMD107), has been linked to an incompletely penetrant, dominantly inherited susceptibility to invasive Staphylococcal infections. At the same time, a recent novel ORAS-like inflammatory syndrome was described in association with a heterozygous missense mutation that appears to exert dominant negative (DN) effects. In this manuscript, we report the identification of a novel homozygous missense mutation, c.595 T > A; p.(Trp199Arg), in a Moroccan infant with an ORAS phenotype and provide experimental evidence for its pathogenicity. We go on to systematically review the literature for OTULIN-associated conditions by using the GenIA database (www.geniadb.net) to collect, extract and harmonize all clinical, laboratory and functional data for published patients and variants. Our comprehensive synthesis of genotypic, phenotypic, and mechanistic data enables a more in-depth view of the diverse mechanisms and pathways by which the OTULIN pathogenic variants may lead to human immune disease. This review may help variant classification activities and inform future variant evaluation, as well as the development of diagnostic and management guidelines. It also identifies current knowledge gaps and raises additional questions warranting future investigation., Competing Interests: Declaration of competing interest All authors declare no conflicts of interest concerning this work., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
47. Genetic Diagnosis of Inborn Errors of Immunity in an Emerging Country: a Retrospective Study of 216 Moroccan Patients.
- Author
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Moundir A, Ouair H, Benhsaien I, Jeddane L, Rada N, Amenzoui N, Jouhadi Z, Adnane F, Hafidi NE, Kili A, Bourhanbour Drissi A, Babakhouya A, Benmiloud S, Hbibi M, Benajiba N, Hida M, Bouskraoui M, Mahraoui C, Admou B, Bakkouri JE, Ailal F, and Bousfiha AA
- Subjects
- Humans, Retrospective Studies, Mutation genetics, Hereditary Complement Deficiency Diseases, Morocco epidemiology, Genetic Testing
- Abstract
Purpose: Genetic testing provides great support to validate the clinical diagnosis of inborn errors of immunity (IEI). However, the high cost and advanced technology make these tests inaccessible to a large proportion of patients in low-income countries. In the present study, we aim to evaluate the Moroccan experience in genetic testing and to report the main molecular features and difficulties encountered in genetic diagnosis., Methods: We performed a multi-center retrospective analysis of all patients with a molecular diagnosis and registered in the national registry between 2010 and 2022. To estimate the impact of the newly identified mutations, we calculated the Combined Annotation Dependent Depletion (CADD) score and the mutation significance cutoff (MSC) for each variant., Results: A total of 216 (29%) patients received a genetic diagnosis out of 742 patients with IEI included in the registry. All genetic tests were performed in the context of thesis projects (40%) or international collaborations (60%). A set of 55 genetic defects were identified, including 7 newly reported: SNORA31, TBX21, SPPL2A, TYK2, RLTPR, ZNF341, and STAT2 GOF. Genetic diagnoses were more frequent in the defects of innate and intrinsic immunity with a percentage of 78%, while antibody deficiencies had a lower frequency with a percentage of 17.5%. Only one genetic diagnosis has been made in the complement deficiency group. The most commonly used molecular techniques were Sanger sequencing (37%) followed by targeted gene sequencing (31%)., Conclusion: The thesis projects and collaborations were beneficial as they allowed us to provide a definitive genetic diagnosis to 29% of the patients and to contribute to the identification of new genetic defects and mutations. These results offer insight into the progress made in genetic diagnoses of IEI in Morocco, which would provide a baseline for improving the clinical management of patients with IEI., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
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48. Lead poisoning with encephalic and neuropathic involvement in a child: case report.
- Author
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Rouzi L, Elhamri H, Kalouch S, Salam S, Moutawakil BE, Chaoui H, Badrane N, Fekhaoui M, and Jouhadi Z
- Subjects
- Humans, Child, Female, Child, Preschool, Lead, Brain, Family, Succimer, Lead Poisoning diagnosis, Lead Poisoning drug therapy, Lead Poisoning etiology, Peripheral Nervous System Diseases complications
- Abstract
Lead is a toxic substance in our environment that affects adults and children of all socioeconomic backgrounds, lead poisoning is one of the most common exposures that can cause inter alia significant neurological and functional damage in humans. Children are particularly vulnerable because of the effects of the toxicity on their developing nervous systems with potentially irreversible consequences. We report a case of severe lead poisoning encephalo-neuropathy in a 3-year-old girl, admitted for progressive paraplegia, swallowing disorders, and aphasia. A multitude of investigations undertaken could not explain her atypic symptoms, so anamnesis was redone in the sense of a toxic origin, we found a notion of pica, and a traditional herbalist father, so probably consumption of medications based on traditional medicine products. A venous blood lead level (BLL) was extremely elevated at 176.4 μg/l. The child was treated with an oral chelator succimer (SUCCICAPTAL). During the two following months in the intensive care unit, the child showed progressive respiratory distress and worsening signs of the nervous system. Despite treatment and the use of lead chelators, the patient died due to septic shock. Lead is highly toxic even at very low exposure levels, at high levels of exposure, it can damage the reproductive organs, immune system, liver and kidneys. in children, it can affect neurocognitive and behavioral development that could be irreversible. Peripheral and central nervous system damage should be considered as a possible manifestation of lead poisoning., Competing Interests: The authors declare no competing interests., (Copyright: Latifa Rouzi et al.)
- Published
- 2022
- Full Text
- View/download PDF
49. Targeted Gene Sanger Sequencing Should Remain the First-Tier Genetic Test for Children Suspected to Have the Five Common X-Linked Inborn Errors of Immunity.
- Author
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Chan KW, Wong CY, Leung D, Yang X, Fok SFS, Mak PHS, Yao L, Ma W, Mao H, Zhao X, Liang W, Singh S, Barbouche MR, He JX, Jiang LP, Liew WK, Le MHT, Muktiarti D, Santos-Ocampo FJ, Djidjik R, Belaid B, Ismail IH, Abdul Latiff AH, Lee WS, Chen TX, Liu J, Jin R, Wang X, Chien YH, Yu HH, Raj D, Raj R, Vaughan J, Urban M, van den Berg S, Eley B, Lee AC, Isa MS, Ang EY, Lee BW, Yeoh AEJ, Shek LP, Quynh Le NN, Nguyen VAT, Phan Nguyen Lien A, Capulong RD, Mallillin JM, Villanueva JCMM, Camonayan KAB, Vera M, Casis-Hao RJ, Lobo RCM, Foronda R, Binas VWE, Boushaki S, Kechout N, Phongsamart G, Wongwaree S, Jiratchaya C, Lao-Araya M, Trakultivakorn M, Suratannon N, Jirapongsananuruk O, Chantveerawong T, Kamchaisatian W, Chan LL, Koh MT, Wong KJ, Fong SM, Thong MK, Latiff ZA, Noh LM, de Silva R, Jouhadi Z, Al-Saad K, Vignesh P, Jindal AK, Rawat A, Gupta A, Suri D, Yang J, Au EY, Kwok JS, Chan SY, Hui WY, Chua GT, Duque JR, Cheong KN, Chong PCY, Ho MHK, Lee TL, Wong WH, Yang W, Lee PP, Tu W, Yang XQ, and Lau YL
- Subjects
- Child, Genetic Testing, High-Throughput Nucleotide Sequencing, Humans, Exome Sequencing, Agammaglobulinemia diagnosis, Agammaglobulinemia genetics, X-Linked Combined Immunodeficiency Diseases genetics
- Abstract
To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited regions, our centre developed and offered free genetic testing for the most common IEI by Sanger sequencing (SS) since 2001. With the establishment of The Asian Primary Immunodeficiency (APID) Network in 2009, the awareness and definitive diagnosis of IEI were further improved with collaboration among centres caring for IEI patients from East and Southeast Asia. We also started to use whole exome sequencing (WES) for undiagnosed cases and further extended our collaboration with centres from South Asia and Africa. With the increased use of Next Generation Sequencing (NGS), we have shifted our diagnostic practice from SS to WES. However, SS was still one of the key diagnostic tools for IEI for the past two decades. Our centre has performed 2,024 IEI SS genetic tests, with in-house protocol designed specifically for 84 genes, in 1,376 patients with 744 identified to have disease-causing mutations (54.1%). The high diagnostic rate after just one round of targeted gene SS for each of the 5 common IEI (X-linked agammaglobulinemia (XLA) 77.4%, Wiskott-Aldrich syndrome (WAS) 69.2%, X-linked chronic granulomatous disease (XCGD) 59.5%, X-linked severe combined immunodeficiency (XSCID) 51.1%, and X-linked hyper-IgM syndrome (HIGM1) 58.1%) demonstrated targeted gene SS should remain the first-tier genetic test for the 5 common X-linked IEI., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Chan, Wong, Leung, Yang, Fok, Mak, Yao, Ma, Mao, Zhao, Liang, Singh, Barbouche, He, Jiang, Liew, Le, Muktiarti, Santos-Ocampo, Djidjik, Belaid, Ismail, Abdul Latiff, Lee, Chen, Liu, Jin, Wang, Chien, Yu, Raj, Raj, Vaughan, Urban, Berg, Eley, Lee, Isa, Ang, Lee, Yeoh, Shek, Quynh Le, Nguyen, Phan Nguyen Lien, Capulong, Mallillin, Villanueva, Camonayan, Vera, Casis-Hao, Lobo, Foronda, Binas, Boushaki, Kechout, Phongsamart, Wongwaree, Jiratchaya, Lao-Araya, Trakultivakorn, Suratannon, Jirapongsananuruk, Chantveerawong, Kamchaisatian, Chan, Koh, Wong, Fong, Thong, Latiff, Noh, Silva, Jouhadi, Al-Saad, Vignesh, Jindal, Rawat, Gupta, Suri, Yang, Au, Kwok, Chan, Hui, Chua, Duque, Cheong, Chong, Ho, Lee, Wong, Yang, Lee, Tu, Yang and Lau.)
- Published
- 2022
- Full Text
- View/download PDF
50. Burden of invasive pneumococcal disease in children in Casablanca, Morocco four years after the introduction of pneumococcal vaccination.
- Author
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Chikhaoui A, Nzoyikorera N, Diawara I, Jouhadi Z, and Zerouali K
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Morocco epidemiology, Retrospective Studies, Streptococcus pneumoniae, Vaccination, Pneumococcal Infections epidemiology, Pneumococcal Infections prevention & control, Pneumococcal Vaccines
- Abstract
Streptococcus pneumonia is a common bacterium that can cause several types of infections, including invasive infections especially in children aged <5 years. The aim of this work is to report the different aspects of invasive pneumococcal disease (IPD) in a pediatric hospital in Casablanca, Morocco 4 years after the implementation of pneumococcal vaccination. We conducted a descriptive, retrospective study over a 4-year period from January 2015 to December 2018 in A. Harouchi Pediatric Hospital in Casablanca. This study included hospitalized children aged 0 to 14 years´ old who had an IPD. The data was collected using a data collection sheet from archived patient records and computerized laboratory database; organization of data was done using Microsoft Excel 2016 and analysis was done using SPSS-20. A total of 68 patients were included in this series over the 4-year period. Meningitis was the most common IPD (54.41%) followed by bacteremia (19.17%) and then pneumonia (16.17%). Of the 35 serogrouped strains, 7 were included in the pneumococcal conjugate vaccine (PCV) 10 (20%), 6 were PCV13-nonPCV10 serotypes (17.14%) and 6 were non-vaccine serotypes (17.14%). Among the strains tested for their antibiotic resistance profile, 32.70% were resistant to penicillin, tetracycline (29.78%), erythromycin (20.75%) and cotrimoxazole (17.31%). One strain was intermediate to ceftriaxone. The evolution was unfavorable for 18 patients (26.47%). This study reported high resistance rates to penicillin, tetracyclin and erythromycin. The mortality essentially concerned meningitis patients. Ongoing surveillance of antibiotic susceptibility and serotype distribution is needed by a national surveillance network., Competing Interests: The authors declare no competing interest., (Copyright: Amar Chikhaoui et al.)
- Published
- 2022
- Full Text
- View/download PDF
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