1. Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)
- Author
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Hiroshi Shintani, Koutarou Hatano, Haruaki Ishibashi, Yoshio Endo, Yuuki Imazato, Kousuke Noguchi, Shun-ichiro Ogura, Hiroyuki Yoshitake, Yan Li, Emel Canbay, Satoshi Wakama, Yutaka Yonemura, Akiyoshi Mizumoto, Yang Liu, Masamitu Hirano, Kazuhiro Yamada, Nobuyuki Takao, and Masumi Ichinose
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Peritoneal metastasis ,ferrochelatase ,ABCG2 ,Photodynamic diagnosis ,Review ,lcsh:RC254-282 ,aminolevulinic acid ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Perioperative chemotherapy ,medicine ,PEPT1 ,030212 general & internal medicine ,peritoneal surface malignancies ,Terminal stage ,business.industry ,photodynamic diagnosis (PDD) ,Cancer ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Surgery ,030220 oncology & carcinogenesis ,business ,Cytoreductive surgery - Abstract
In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM.
- Published
- 2017