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Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA).

Authors :
Yutaka Yonemura
Yoshio Endo
Canbay, Emel
Yang Liu
Haruaki Ishibashi
Akiyoshi Mizumoto
Masamitu Hirano
Yuuki Imazato
Nobuyuki Takao
Masumi Ichinose
Kousuke Noguchi
Yan Li
Satoshi Wakama
Kazuhiro Yamada
Koutarou Hatano
Hiroshi Shintani
Hiroyuki Yoshitake
Shun-ichiro Ogura
Source :
Cancers; Mar2017, Vol. 9 Issue 3, p23, 13p
Publication Year :
2017

Abstract

In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726694
Volume :
9
Issue :
3
Database :
Complementary Index
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
122041434
Full Text :
https://doi.org/10.3390/cancers9030023