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Abstract In the process of tumor treatment, systemic drug administration is hindered by biological barriers, leading to the retention of a large number of drug molecules in healthy tissues and causing unavoidable side effects. The precise deployment of drugs at the tumor site is expected to alleviate this phenomenon. Here, we take endostatin and Her2 (+) tumors as examples and develop an intelligent drug with simple “wisdom” by endowing mesenchymal stem cells (MSCs) with an intelligent response program (iMSCEndostatin). It can autonomously perceive and distinguish tumor cells from non-tumor cells, establishing a logical connection between tumor signals and drug release. Enable it to selectively deploy drugs at the tumor site, thereby locking the toxicity of drugs at the tumor site. Unlike traditional aggressive targeting strategies that aim to increase drug concentration at the lesion, intelligent drugs are more inclined to be defensive strategies that prevent the presence of drugs in healthy tissues.

Abstract This paper introduces the efficient medical-images-aimed segment anything model (EMedSAM), addressing the high computational demands and limited adaptability of using SAM for medical image segmentation tasks. We present a novel, compact image encoder, DD-TinyViT, designed to enhance segmentation efficiency through an innovative parameter tuning method called med-adapter. The lightweight DD-TinyViT encoder is derived from the well-known ViT-H using a decoupled distillation approach.The segmentation and recognition capabilities of EMedSAM for specific structures are improved by med-adapter, which dynamically adjusts the model parameters specifically for medical imaging. We conducted extensive testing on EMedSAM using the public FLARE 2022 dataset and datasets from the First Hospital of Zhejiang University School of Medicine. The results demonstrate that our model outperforms existing state-of-the-art models in both multi-organ and lung segmentation tasks.

Abstract Efficient semantic segmentation of large-scale point cloud scenes is a fundamental and essential task for perception or understanding the surrounding 3d environments. However, due to the vast amount of point cloud data, it is always a challenging to train deep neural networks efficiently and also difficult to establish a unified model to represent different shapes effectively due to their variety and occlusions of scene objects. Taking scene super-patch as data representation and guided by its contextual information, we propose a novel multiscale super-patch transformer network (MSSPTNet) for point cloud segmentation, which consists of a multiscale super-patch local aggregation (MSSPLA) module and a super-patch transformer (SPT) module. Given large-scale point cloud data as input, a dynamic region-growing algorithm is first adopted to extract scene super-patches from the sampling points with consistent geometric features. Then, the MSSPLA module aggregates local features and their contextual information of adjacent super-patches at different scales. Owing to the self-attention mechanism, the SPT module exploits the similarity among scene super-patches in high-level feature space. By combining these two modules, our MSSPTNet can effectively learn both local and global features from the input point clouds. Finally, the interpolating upsampling and multi-layer perceptrons are exploited to generate semantic labels for the original point cloud data. Experimental results on the public S3DIS dataset demonstrate its efficiency of the proposed network for segmenting large-scale point cloud scenes, especially for those indoor scenes with a large number of repetitive structures, i.e., the network training of our MSSPTNet is much faster than other segmentation networks by a factor of tens to hundreds.

ObjectivesThis work aimed to study the long-term outcome and function of a heterotopic replanted finger.MethodsRetrospective analysis of two cases of successful finger reconstruction after finger heterotopic replantation. One case was a severed thumb, and the other case was a severed finger. The average follow-up time was 10 years. The clinical outcome and function of the heterotopic replanted finger, including range of motion, grip strength, and sensory recovery, were analyzed,. A comparative analysis was conducted with patients who underwent thumb replantation in the same period.ResultsThe two heterotopically replanted fingers survived. Five months after the heterotopic replantation surgery, a new thumb was reconstructed using the heterotopically replanted thumb and the free tarsometatarsal joint from the foot. In the other case, the finger was reconstructed 1 year later with a free anterolateral thigh flap and the heterotopically replanted finger. The movement of the thumb, the pinching of the fingers, the clenching of the fist, and the feeling recovery were all good. The patient was capable of independently performing daily life and work activities such as eating, dressing, writing, and so on. There was no significant difference in hand function between the patients who received in situ finger replantation and heterotopic replantation during the same period.ConclusionFor severed fingers that cannot be replanted in situ in an emergency situation, heterotopic replantation and secondary reconstruction may be a feasible and practical surgical method.

ObjectiveThis systematic review and meta-analysis assessed the effects of three types of physical exercise (resistance exercise, aerobic exercise, and group exercise), different exercise intervention times (3 months, 6 months), and different exercise intensities (low, moderate, and high) on the improvement of depressive symptoms in older adults aged ≥60 years, as well as to explore the impact of the sustainability of these physical exercise intervention programs on depressive symptoms in older adults.MethodsThe randomized controlled trials (RCTs) on the effect of physical exercise on depressive symptoms in older adults were retrieved from Cochrane Library, Web of Science, PubMed, and Embase Data. The retrieval time limit is from establishing the database to January 7, 2024. We conducted a meta-analysis using a 95% confidence interval (95% CI) and the standardized mean differences (SMD). The I2 statistic was used to assess the heterogeneity of the outcomes of the studies. When I2 50%, we used the random-effects model. Subgroup and sensitivity analyses investigated heterogeneity origins.ResultsThere are 15 articles reported 20 studies, with a total of 1,346 patients, including 689 in the control group and 657 in the experimental group. The findings demonstrated a notable improvement in depression symptoms among older persons as an immediate result of engaging in physical exercise [SMD = −0.82, 95% CI (−1.19, −0.45)]. The subgroup analysis showed that moderate-intensity physical exercise [SMD = −0.25, 95% CI (−0.47, −0.03)], high-intensity physical exercise [SMD = −0.94, 95% CI (−1.37, −0.51)], resistance exercise [SMD = −0.70, 95% CI (−1.20, −0.20)], and group exercise [SMD = −0.97, 95% CI (−1.89, −0.05)], and the exercise intervention time was 3 months [SMD = −0.81, 95% CI (−1.38, −0.23)] or 6 months [SMD = −0.93, 95% CI (−1.46, −0.41)] were more effective in improving depressive symptoms in older adults.ConclusionThe sustainable resistance and group exercise have a better effect on improving depressive symptoms in older adults. Appropriate exercise intervention time can also ensure the sustainable improvement effect of exercise.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/record_email.php, identifier CRD42023405525.

Abstract Background The emergence of the COVID-19 pandemic has sparked unprecedented global challenges. This study intends to investigate changes in the physical fitness of students aged 6–22 during the COVID-19 pandemic and to assess how the pandemic lockdown period affected these markers. Methods According to the National Student Physical Health Standard, a stratified cluster sampling method was used to evaluate the body shape, body function, and physical fitness of children and adolescents (n = 8092) in Xi’an from 2019 to 2021. This study uses SPSS 26.0 (IBM, Chicago, IL, USA) for data statistics and analysis. The connection between physical fitness and years was measured using the one-variable analysis in the general linear model (GLM). Independent t-tests were used to determine the sex (male/female) and area (urban/rural) differences. Results During the lockdown period, Body Mass Index (BMI) and flexibility showed an upward trend, while aerobic, strength, speed, and endurance showed a downward trend. In addition to the BMI of middle and high school students, almost all indicators show significant sex differences. There are urban-rural differences in some indicators, such as chin-ups. Conclusion During the pandemic of COVID-19, the physical fitness of children and adolescents in Xi’an did not change significantly, and there were slight differences among different grades. During the pandemic lockdown period, lifestyle changes and reduced outdoor activities for children and adolescents may be the reasons for the changing trend of various indicators.

Abstract The conservative treatment for Kohler's disease will take several months, but some patients still have flatfoot and persistent pain. From October 2013 to July 2015, 3 children with Kohler's disease underwent navicular decompression and micro-circulation reconstruction surgery in our hospital. All the patients have received conservative treatment for more than 3 months and the effect was poor. X-ray showed the bone density of navicular increased significantly. All patients were followed up over 1 year. The 3 patients recovered well. VAS score decreased from 7.0 to 2.6 at 1 month after the operation. The pain symptom disappeared completely on 3 months after surgery. The density of navicular bone recovered to normal. Navicular decompression and micro-circulation reconstruction surgery may quickly improve the ischemic status of navicular bone, alleviate pain symptom and enable patients to resume normal activity as soon as possible.

Purpose: This study evaluated the first clinical implementation of daily iterative cone beam computed tomography (iCBCT)-guided online adaptive radiation therapy (oART) in the postoperative treatment of endometrial and cervical cancer. Methods and Materials: Seventeen consecutive patients treated with daily iCBCT-guided oART were enrolled in this prospective study, with a reduced uniform 3-dimensional PTV margin of 5 mm. Treatment plans were designed to deliver 45 or 50.4 Gy in 1.8 Gy daily fractions to PTV. Pre- and posttreatment ultrasound and iCBCT scans were performed to record intrafractional bladder and rectal volume changes. The accuracy of contouring, oART procedure time, dosimetric outcomes, and acute toxicity were evaluated. Results: The average time from first iCBCT acquisition to completion of treatment was 22 minutes and 26 seconds. During this period, bladder volume increased by 44 cm3 using iCBCT contouring, whereas rectal volume remained stable (62.9 cm3 pretreatment vs 61.9 cm3 posttreatment). A total of 91.6% of influencers and 88.1% of CTVs required no or minor edits. The adapted plan was selected in all (434) fractions and significantly improved the dosimetry coverage for CTV and PTV, especially the vaginal PTV coverage by nearly 7% (P < .05). The adapted bladder Dmean was 104.61 cGy, and the rectum Dmean was 123.67 cGy, significantly lower than the scheduled plan of 108.24 and 128.19 cGy, respectively. The bone marrow and femur head left and right dosimetry were also improved with adaptation. Grade 2 acute gastrointestinal and genitourinary toxicities were 24% and 0, respectively. There was a grade 3 acute toxicity of decreased white blood cell count in 1 patient. Conclusions: Daily oART was associated with favorable dosimetry improvement and low acute toxicity, supporting its safety and efficacy for postoperative treatment of endometrial and cervical cancer. These results need to be validated in a larger prospective randomized controlled cohort.

In tumor treatment, the deposition of nanoenzymes in normal tissues and cause potential side effects are unavoidable. Here, we designed an intelligent biomimetic nanoenzymes carrier platform (MSCintelligent) that endows the carrier platform with “wisdom” by introducing Affibody-Notch(core)-VP64-GAL4/UAS-HSV-TK artificial signal pathways to mesenchymal stem cells (MSCs). This intelligent nanoenzymes carrier platform is distinguished from the traditional targeting tumor microenvironment or enhancing affinity with tumor, which endue MSCintelligent with tumor signal recognition capacity, so that MSCintelligent can autonomously distinguish tumor from normal tissue cells and feedback edited instructions. In this study, MSCintelligent can convert tumor signals into HSV-TK instructions through artificial signal pathway after recognizing Her2 (+) tumor. Subsequently, the synthesized HSV-TK can rupture MSCintelligent under the mediation of ganciclovir, and release the preloaded Cu/Fe nanocrystal clusters to kill the tumor accurately. Meanwhile, MSCintelligent without recognizing tumors will not initiate the HSV-TK instructions, thus being unresponsive to GCV and blocking the release of nanoenzymes in normal tissues. Consequently, MSCintelligent is the first intelligent biomimetic nanoenzymes carrier platform, which represents a new biomimetic nanoenzymes targeting mode.

Abstract Background The majority of published literature clinically assesses surgical outcomes after lower limb replantation for traumatic amputations. However, patients’ satisfaction and quality of life may not be accurately measured through rigid scoring using standardized patient reported outcome measures. Purpose The aim of this study was to qualitatively assess patient satisfaction and factors associated with achieving good outcomes after successful lower limb replantation surgery. Methods A semi-structured interview was conducted with 12 patients who underwent lower limb replantation surgery following traumatic amputation injuries. The interview focused on the patients’ experience and satisfaction throughout their injury, surgical journey, rehabilitation and reintegration into their communities. An inductive and deductive thematic analysis was applied using the recorded transcripts to evaluate the overall satisfaction of the patients after lower limb replantation surgery. Results The following observations emerged from the structured themes among all the patients interviewed: (1) Family and social support was significantly associated with improved qualities of life and satisfaction after lower limb replantation; (2) Patients were generally satisfied with their outcomes despite limitations in physical capabilities; (3) Satisfaction was associated with acceptance of their cosmetic deformity; (4) Social integration and being able to participate in a meaningful manner was associated with greater satisfaction after recovery. Conclusions Patients who undergo lower limb replantation can have a significantly improved quality of life if they have strong social support, are able to contribute in a meaningful manner to their communities after surgery, and are accepting of their cosmetic deficiencies.

This paper presents a perturbation observer based single-loop robust decoupling control scheme (RDC-PO) for DC-based DFIG with dual voltage source converters to enhance maximum power point tracking (MPPT) and improve fault-ride-through (FRT) capability. The unknown nonlinear effects caused by aerodynamic and modeling uncertainties are aggregated into a perturbation term, which is estimated by a sliding-mode perturbation observer. Then, a single-loop linear feedback controller with no intermediate link is designed to quickly compensate disturbance estimation in real time. Furthermore, the control algorithm does not necessitate a precise DFIG model. Additionally, the incorporation of nonlinear robust control compensates for the inherent limitations of linear control, thereby endowing the proposed control algorithm with the advantages of facile implementation akin to traditional linear control and global consistency characteristic of nonlinear robust control. Simulation results show that RDC-PO has superior transient and steady-state performance compared with double-loop feedback controller (DFC) and single-loop feedback control (SFC) in MPPT and FRT. Finally, Experiment verifies the practical operability of the proposed strategy.

Abstract Background Training senior radiation therapists as “adapters” to manage influencers and target editing is critical in daily online adaptive radiotherapy (oART) for cervical cancer. The purpose of this study was to evaluate the accuracy and dosimetric outcomes of automatic contouring and identify the key areas for modification. Methods A total of 125 oART fractions from five postoperative cervical cancer patients and 140 oART fractions from five uterine cervical cancer patients treated with daily iCBCT-guided oART were enrolled in this prospective study. The same adaptive treatments were replanned using the Ethos automatic contours workflow without manual contouring edits. The clinical target volume (CTV) was subdivided into several separate regions, and the average surface distance dice (ASD), centroid deviation, dice similarity coefficient (DSC), and 95% Hausdorff distance (95% HD) were used to evaluate contouring for the above portions. Dosimetric results from automatic oART plans were compared to supervised oART plans to evaluate target volumes and organs at risk (OARs) dose changes. Results Overall, the paired CTV had high overlap rates, with an average DSC value greater than 0.75. The uterus had the largest consistency differences, with ASD, centroid deviation, and 95% HD being 2.67 ± 1.79 mm, 17.17 ± 12 mm, and 10.45 ± 5.68 mm, respectively. The consistency differences of the lower nodal CTVleft and nodal CTVright were relatively large, with ASD, centroid deviation, and 95% HD being 0.59 ± 0.53 mm, 3.6 ± 2.67 mm, and 5.41 ± 4.08 mm, and 0.59 ± 0.51 mm, 3.6 ± 2.54 mm, and 4.7 ± 1.57 mm, respectively. The automatic online-adapted plan met the clinical requirements of dosimetric coverage for the target volume and improved the OAR dosimetry. Conclusions The accuracy of automatic contouring from the Ethos adaptive platform is considered clinically acceptable for cervical cancer, and the uterus, upper vaginal cuff, and lower nodal CTV are the areas that need to be focused on in training.

Objectives: This study aims to examine the geographical variation in physical fitness levels among Chinese children and adolescents in Shaanxi province. Methods: A total of 19,175 children from Shaanxi province with physical fitness data in 2019, participated in the study. Physical fitness was assessed using body mass index, force vital capacity, 50 m sprint, sit and reach, 1 min rope skipping, sit-ups, 50 m × 8 round-trip running, standing long jump, pull-ups, 800 m, and 1000 m running, and their standardized scores were aggregated to form a summary score. The total score is used to classify the physical fitness levels into four grades (excellence to failure). Results: The Guanzhong (GZ) region scored the highest, while Northern Shaanxi (NS) scored the lowest. The excellence rate for physical fitness was highest in GZ and lowest in NS, while the failure rate was highest in NS and lowest in GZ. Notably, children and adolescents in NS demonstrated the best endurance levels despite their overall lower fitness scores. The comprehensive physical fitness among Chinese children and adolescents in Shaanxi province showed significant regional disparities. GZ region exhibited the highest physical fitness levels, while Northern Shaanxi had the lowest. Conclusions: Region-specific interventions and targeted health policies are essential to address these disparities and improve the overall physical health status of children and adolescents in Shaanxi province.

The objective of this study was to assess the concurrent validity of the Kunwei force plate system in relation to variables during a counter-movement jump (CMJ) task, in comparison to the Kistler in-ground force plate system, which is considered the “gold standard”. Methods: In a single testing session, the Kunwei force plates were placed directly on top of the in-ground Kistler force plate. This allowed for the simultaneous collection of vertical ground reaction forces from 30 participants (male, age = 22.8 ± 2.8 years, body mass = 74.3 ± 12.3 kg, height 178.2 ± 4.6 cm) during CMJ tests. The consistency between force plate systems was assessed using ordinary least products regression (OLPR) with bootstrapped 95% confidence intervals and the Interclass Correlation Coefficient (ICC). Results: There was no fixed or proportional bias in the CMJ variables measured between the force plate systems. The variables exhibited a strong correlation across the force plates during the CMJ task (ICC > 0.950, p < 0.01). Conclusion: The findings of this study indicate that there was no statistical difference between the Kunwei and Kistler force plate systems when evaluating common CMJ strategy and outcome variables, which are considered the gold standard. Hence, the Kunwei force plate can be regarded as a reliable substitute for the established industry benchmark in evaluating the force–time characteristics of the CMJ. Researchers, athletes, and coaches have the option to utilize this affordable and portable choice as a substitute for the more expensive laboratory-based force plate system. This alternative allows for the precise measurement of CMJ performance and force–time variables.

Abstract Background In this study, by analyzing the correlation between various components of health-related physical fitness (HPF) and liver function indicators, the indicators of physical fitness that were highly correlated with liver function and could be monitored at home were screened to prevent more serious liver disease in the future, and to provide experimental basis for prescribing personalized exercise. Methods A total of 330 faculties (female = 198) of a university were recruited. The indicators of HPF and liver function were measured. Spearman correlation analysis, multivariate linear regression, and cross-lagged panel model was used to data statistics. Results In males, body fat (BF) was positively correlated with alanine aminotransferase (ALT); vital capacity and the vital capacity index were positively correlated with albumin; and vertical jump was positively correlated with globulin and negatively correlated with the albumin-globulin ratio (P

Background: Methamphetamine use disorder (MUD) is a global health problem. Studies have shown Tai Chi is a potential treatment for MUD. We aimed to explore the effectiveness of Tai Chi in improving drug cravings, attention bias, and physical fitness in men with MUD compared with aerobic exercise. Methods: A total of forty-eight participants (mean age 39.1 ± 8.7 years) were randomly assigned to either the Tai Chi group (TC) or the running group (RG). The TC performed 60 min of moderate-intensity (65–75% HRmax) Tai Chi exercise three times a week. The RG performed 60 min of moderate-intensity (65–75% HRmax) running on a treadmill three times a week. Before and after the intervention, drug cravings, attention bias, and physical fitness were evaluated. Results: After 12 weeks, we found the TC significantly improved in attention bias (F (1, 43) = 6.023, p = 0.019, d = −0.42) and reaction time (F (1, 43) = 6.181, p = 0.017, d = −0.72). No significant improvement was found in other variables in the TC, compared to the RG (p > 0.05). Conclusions: The 12-week Tai Chi intervention improved attention bias and reaction time, compared to RG. Tai Chi exercise might be a potential auxiliary method for the rehabilitation for men with MUD.

Abstract This paper considers the output‐feedback controller for a class of stochastic cascade nonlinear systems with stochastic integral input‐to‐state stable inverse dynamics, unknown control coefficients, and matching disturbances. By augmenting the existing disturbance as an extended state, a novel extended state observer (ESO) is constructed based on the Riccati differential equation. Based on the techniques of Nussbaum function and backstepping, an adaptive output feedback controller is proposed to guarantee that all system states of the resulting closed‐loop system are globally asymptotically stable in probability. Meanwhile, the other signals are almost surely bounded. Additionally, the validity of the proposed control method is verified by simulation examples.

En el presente trabajo analizamos las ventajas y las deficiencias del uso de los métodos cuantitativo y cualitativo en estudios enfocados en lenguas extranjeras. A modo de ejemplo, observamos dos casos cuyos estudios están basados respectivamente en ambos métodos: en el primer caso se utiliza el programa SPSS (https://www.ibm.com/spss) como herramienta de análisis y en el segundo se emplea el programa Atlas.ti (https://atlasti.com/). En cada uno de estos casos se reflexiona sobre su aplicación en la investigación, analizando, por ejemplo, si la explicación es correcta con el método seguido y las herramientas adoptadas o si se han omitido algunos factores en la recogida y análisis de datos. Con el desarrollo de la tecnología digital e informática en las últimas décadas, han aparecido abundantes programas y plataformas en línea, lo cual hace factible de forma eficaz la recogida de datos a distancia y su procesamiento automático. Por consiguiente, en este trabajo también se aborda la aplicación de las nuevas tecnologías en la recogida y análisis de datos. Asimismo, para corregir, en la medida de lo posible, las deficiencias reveladas en estudios basados en métodos cuantitativo y cualitativo, se expone la posible solución, basada en el diseño de un método mixto de los dos modelos. La última parte del trabajo es una breve presentación de un procedimiento que utiliza esta estrategia mixta: la Metodología-Q. Nos proponemos, mediante su exposición y análisis, arrojar luz sobre futuros estudios en el terreno de la lengua extranjera.

In this paper, mining-induced deformation for haulage drifts of the hanging wall at Jinshandian Iron Mine is investigated, based on 8 monitoring stations adopted laser convergence meters. Monitoring results are analyzed to divide deformation-time curves into three types: fluctuation type, partial folding type and whole folding type. Moreover, it is found that tensile deformation is easy to occur in the roadway section corresponding to no folding type and partial folding type. And in the roadway section with folding type curve, it is obviously affected by the steeply anti-inclined structural plane. Furthermore, the relative position relationship between mining activities and a monitoring station is established through local coordinate system. Mining effects on roadway deformation are studied based on rectangular coordinate components and polar coordinate components respectively. The critical value of coordinate components that have a significant impact on roadway deformation have been determined. At last, combined with results of mining impact analysis, deformation mechanisms corresponding to the three deformation curves are revealed. These results help determine the appropriate support time and adopt targeted support schemes.

The topspin forehand is the most frequent and effective shot in top-level table tennis matches. The present study assesses the biomechanical differences in the topspin forehand stroke technique when the incoming ball is in different rotations. Eight national level-1 male table tennis athletes (176.6 ± 4.8 cm, 70.8 ± 6.6 kg, 20.9 ± 2.4 yr) performed two kinds of techniques—topspin forehand strokes against topspin (AT) and against backspin (AB) balls, respectively. The kinematic parameters of their bodies and rackets were calculated. Meanwhile, the force plates analyzed their lower limb moments through inverse dynamics. Paired t-test and non-parametric paired t-test mapping were used to assess the differences between the two conditions. Their center of gravity (COG) vertical distance, elbow flexion, thorax–pelvis flexion, and knee flexion angles had significant differences during the stroke phase (p < 0.05). The moment of the racket-side hip rotation and ankle dorsiflexion showed significant differences during the stroke phase (p < 0.05). The racket velocity, angle, and trajectories showed significant differences at characteristic moments (p < 0.05). This study revealed the different topspin forehand stroke techniques in table tennis, even though the two movements look similar. Compared with AT strokes, the athletes kept a straight elbow and lower center of gravity than they did during the stroke phase of AB strokes. They increased the distance of the racket trajectory and velocity to meet the incoming ball with a backspin, especially in the vertical direction. This detailed information is necessary for beginners to improve the efficiency of their forehand topspin technique, especially in strokes against incoming balls with different rotations.

Background: This study aimed to derive the effects of walking while using a mobile phone on balance perturbation and joint movement among young adults. Methods: Sixteen healthy college students with no history of brain injury were tested. The participants were asked to walk under four different conditions: (1) walking, (2) browsing, (3) dialing, and (4) texting. Indicators related to balance control and lower limb kinematic/kinetic parameters were analyzed using the continuous relative phase and statistical nonparametric mapping methods. Results: Walking while using a mobile phone slowed participants’ gait speed and reduced the cadence, stride length, and step length. The posterior tilt angle (0–14%, 57–99%), torque of the hip flexion (0–15%, 30–35%, 75–100%), and angle of the hip flexion (0–28%, 44–100%) decreased significantly. The activation of biceps femoris and gastrocnemius, hip stiffness, and ankle stiffness increased significantly. This impact on gait significantly differed among three dual tasks: texting > browsing > dialing. Conclusion: Che overlap of walking and mobile phone use affects the gait significantly. The “hip–ankle strategy” may result in a “smooth” but slower gait, while this strategy was deliberate and tense. In addition, this adjustment also increases the stiffness of the hip and ankle, increasing the risk of fatigue. Findings regarding this effect may prove that even for young healthy adults, walking with mobile phone use induces measurable adjustment of the motor pattern. These results suggest the importance of simplifying the control of the movement.

The outer membrane (OM) of Gram-negative bacteria is a formidable barrier against antibiotics. Understanding the structure and function of the OM is essential for the discovery of novel membrane-acting agents against multidrug-resistant Gram-negative pathogens. However, it remains challenging to obtain three-dimensional structure of bacterial membranes using crystallographic approaches, which has significantly hindered the elucidation of its interaction with antibiotics. Here, we developed an asymmetric OM model consisting of rough lipopolysaccharide (LPS) and three key types of phospholipids. Using coarse-grained molecular dynamics simulations, we investigated the interaction dynamics of LPS-containing OM with the polymyxins, a last-line class of antibiotics against Gram-negative ‘superbugs’. We discovered that polymyxin molecules spontaneously penetrated the OM core sugar region where most were trapped before entering the lipid A region. Examination of the free energy profile of polymyxin penetration revealed a major free energy barrier at the LPS inner core and lipid A interface. Further analysis revealed calcium ions predominantly distributed in the inner core region and mediated extensive cross-linking interactions between LPS molecules, thereby inhibiting the penetration of polymyxins into the hydrophobic region of the OM. Collectively, our results provide novel mechanistic insights into an intrinsic defense of Gram-negative bacteria to polymyxins and may help identify new antimicrobial targets.

Indoor scene understanding is an active research topic that has recently gained increasing attention in both computer graphics and computer vision community. This paper presents a novel automatic point cloud instance abstraction and segmentation of indoor scenes using learned pairwise planar patch relations. Planar patches have sufficient representative power to abstract the semantics in mostly man-made 3D indoor scenes. To exploit the planar patch relationships, a new indoor point clouds dataset is automatically derived from the public dataset ScanNet, which can be adopted for training a pairwise patch relation classifier. Given the pre-processed indoor scene point clouds, a set of planar patches are generated to provide robust and compact representation of indoor objects and parts. For each extracted planar patch, a feature descriptor in view of its geometric properties and appearance is calculated. Owing to the proposed feature descriptors, the relations of pairwise planar patch are measured and can be fed into the pre-trained patch relation classifier. To yield the instance segmentation of indoor scenes, a robust graph-based algorithm is adopted to group these planar patches which incorporate the learned patch relations. Experimental results demonstrate that our proposed approach can produce instance semantic segmentation of various cluttered indoor scenes robustly and efficiently.

Between the completion of the mesenchymal stem cell (MSCs) preparation and the transplantation into the patient, there is a time interval during which the quality control and transport of MSC products occur, which usually involves suspending the cells in normal saline in an oxygen–glucose deprivation (OGD) microenvironments. Thus, how to effectively maintain MSC viability during the abovementioned time interval is bound to play a significant role in the therapeutic effect of MSC-based therapies. Recently, menstrual blood–derived endometrial stem cells (MenSCs) have attracted extensive attention in regenerative medicine due to their superior biological characteristics, including noninvasive protocols for their collection, abundant source material, stable donation, and autotransplantation. Therefore, this study aimed to mainly determine the effect of storage temperature on the maintenance of MenSC viabilities in an OGD microenvironment, and to preliminarily explore its potential mechanism. Simultaneously, the effects of solvents commonly used in the clinic on MenSC viability were also examined to support the clinical application of MenSCs. Consequently, our results demonstrated that in the OGD microenvironment, a nonfreezing low temperature (4°C) was suitable and cost-effective for MenSC storage, and the maintenance of MenSC viability stored at 4°C was partly contributed by the sustained releases of autophagy-produced energy. Furthermore, the addition of human serum albumin effectively inhibited the cell sedimentations in the MenSC suspension. These results provide support and practical experience for the extensive application of MenSCs in the clinic.

Screening of osteochondral lesions of the talus (OLTs) from MR imags usually requires time and efforts, and in most case lesions with small size are often missed in clinical practice. Thereore, it puts forward higher requirements for a more efficient OLTs screening method. To develop an automatic screening system for osteochondral lesions of the talus (OLTs), we collected 92 MRI images of patients with ankle pain from Qilu Hospital of Shandong University and proposed an AI (artificial intelligence) aided lesion screening system, which is automatic and based on deep learning method. A two-stage detection method based on the cascade R-CNN model was proposed to significantly improve the detection performance by taking advantage of multiple intersection-over-union thresholds. The backbone network was based on ResNet50, which was a state-of-art convolutional neural network model in image classification task. Multiple regression using cascaded detection heads was applied to further improve the detection precision. The mean average precision (mAP) that is adopted as major metrics in the paper and mean average recall (mAR) was selected to evaluate the performance of the model. Our proposed method has an average precision of 0.950, 0.975, and 0.550 for detecting the talus, gaps and lesions, respectively, and the mAP, mAR was 0.825, 0.930. Visualization of our network performance demonstrated the effectiveness of the model, which implied that accurate detection performance on these tasks could be further used in real clinical practice.

Summary: Objective: To introduce the application of Ilizarov techniques in the treatment of syndactyly. Methods: From January 2016 to January 2019, 6 cases of pediatric syndactyly were treated by the simple Ilizarov external fixator device in our hospital. The skin and soft tissue between involved fingers were lengthened with external fixator slow traction. The speed was controlled at 1–2 ​mm per day, six times a day. When the length of the interphalangeal soft tissue is up to the requirement, Z-plasty incision and finger web flap were performed to separate the fingers. Skin grafting is generally not required. Results: All the 6 cases had been followed up over 12 months. In all cases, sufficient skin was obtained without infection or necrosis. The appearance and function of the released fingers were satisfactory. Conclusion: According to the principle of stress–strain, with the aid of simple Ilizarov external fixator, sufficient skin had been obtained to reconstruct the finger web and cover the finger side defect. With functional rehabilitation, excellent functions and satisfactory appearance of the fingers were achieved. The translational potential of this article: This paper reviews recent progress on the treatment of syndactyly, and report the clinical application a new simple Ilizarov external fixator device to treat the complete syndactyly and get good results.

Abstract Background Research into the pathogenesis of endometriosis (EMs) would substantially promote its effective treatment and early diagnosis. However, the aetiology of EMs is poorly understood and controversial despite the progress in EMs research in the last several decades. Currently, accumulating evidence has shed light on the importance of endometrial stem cells (EnSCs) residing in the basal layer of endometrium in the establishment and progression of endometriotic lesions. Therefore, we aimed to identify the differences between EnSCs isolated from the ectopic lesions of EMs patients (EnSC-EM-EC) and EnSCs isolated from eutopic endometrium of control group (EnSC-Control). We further performed preliminary exploration of the potential signalling pathways involved in the above abnormalities. Methods EnSC-EM-EC (n = 12) and EnSC-Control (n = 13) were successfully isolated. Then, the proliferative capacity, migratory capacity and angiogenic potential of EnSCs were evaluated by conventional MTT assay, flow cytometry, wound healing assay, transwell assay, tube formation assay and chick embryo chorioallantoic membrane assay respectively. The expression of 11 angiogenesis-associated biological factors and 11 cytokines secreted by EnSCs and 17 adhesion molecules expressed on EnSCs were determined by protein array assays respectively. Differentially expressed genes (DEGs) between EnSC-EM-EC and EnSC-Control were analysed by RNA-sequence. Results EnSC-EM-EC exhibited unique biological characteristics, including prolonged mitosis, enhanced migratory capacity and enhanced angiogenic potential. Greater amounts of angiogenic factors (especially VEGF and PDGF) were secreted by EnSC-EM-EC than by EnSC-Control; however, the distinct profiles of cytokines secreted by EnSC-EM-EC and adhesion molecules expressed by EnSC-EM-EC require further investigation. A total of 523 DEGs between EnSC-EM-EC and EnSC-Control were identified and analysed using the KEGG and Gene Ontology databases. Conclusions Our results not only improve the understanding of EMs but also contribute to the development of EnSC-EM-EC as a tool for EMs drug discovery. These cells could be of great help in exploiting promising therapeutic targets and new biomarkers for EMs treatment and prognosis.

Abstract Background Many older adults in the U.S. do not achieve the recommended amount of physical activity (PA) to fully realize a myriad of health benefits. Adiposity is one of those important correlates of PA and sedentary behaviors. However, the full extent to which adiposity is associated with PA and stationary time (STA) is uncertain. Therefore, we examined the association of adiposity with objectively measured PA and STA in black and white older adults. Methods We conducted a cross-sectional study of older adults enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study 2003–2007 who participated in an ancillary accelerometer study 2009–2013. Assessment of body mass index (BMI) and waist circumference (WC) was completed during an in-home visit in the parent study. PA was measured by Actical™ accelerometers, which provided estimates of moderate-to-vigorous-intensity PA (MVPA), light-intensity PA (LPA), and STA for 4–7 consecutive days. Data from accelerometers were standardized to square root percentages of total wear time per day (SqrtMVPA%, SqrtLPA%, and SqrtSTA%). Interactions were tested for BMI and WC by race and sex, separately. Results Data were available for 7873 participants (69.8 ± 8.7 yr, 54.2% women, 31.5% African American). In mixed linear regression models, significant interactions existed in BMI by race and sex for the SqrtMVPA%, WC by race and sex for the SqrtMVPA% and the SqrtLPA% model(p

The space Brayton nuclear reactor system usually adopts the helium–xenon gas mixture (He–Xe) as the working fluid. The flow of He–Xe in the micro channel regenerator of the system is generally laminar. Since the properties of He–Xe are significantly different from those of common pure gases, the impact of this difference on the laminar flow and heat transfer needs to be evaluated. In present study, the numerical simulations of laminar convective heat transfer for helium, nitrogen and He–Xe are conducted by Ansys Fluent. Compared with simulation results, the applicability of existing laminar friction factor (f) and Nusselt number correlations is evaluated. By establishing the functions of property ratios with the temperature ratio and the mixing ratio, a new laminar f correlation for property-variable He–Xe is proposed. Results show that the calculation error of existing f correlations for He–Xe is obviously large, exceeding 13%. With the new f correlation, the predictions of laminar f for He–Xe are in good agreement with the simulation results in the fully developed region, and the calculation error is reduced to 3%.

Tumor necrosis factor-α–induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which is associated with inflammation and tumorigenesis. The potential role of TNFAIP8 in a tumor immune microenvironment in skin cutaneous melanoma (SKCM) has not yet been investigated. The TNFAIP8 expression was evaluated via gene expression profiling interactive analysis (GEPIA). We also evaluated the influence of TNFAIP8 on overall survival via GEPIA and PrognoScan. After GO and KEGG pathway analyses, the correlation between the TNFAIP8 expression level and immune cells or gene markers of the immune infiltration level was explored by R-language. The result showed the TNFAIP8 expression was significantly reduced in SKCM in comparison with normal control. In SKCM, the TNFAIP8 expression in higher levels was associated with the better overall survival. The high expression of TNFAIP8 was positively correlated with the immune score and promoted immune cell infiltration in SKCM patients. TNFAIP8 can be a positive prognosis marker or new immunotherapy target in SKCM.

Este trabajo estudia los niveles de adquisición de los tiempos aspectuales pasados del español por aprendices sinohablantes basados en los datos de comprensión y producción de un corpus. El objetivo de este trabajo de síntesis es evaluar la comprensión y producción del aspecto en español en la interlengua de aprendices sinohablantes observada en distintos niveles de competencia lingüística (de B1 a C1) a través de la puesta en relación entre los datos procedentes de pruebas sobre la comprensión y la producción del aspecto en español como L2. Los resultados muestran que nuestros aprendices solo consiguen comprender incluso en el nivel C1 parte de la información de input, aunque buscan compensar este vacío ajustando sus estrategias en la producción, si bien esta estrategia parece más una regla mecánica, en lugar de un patrón interno cercano a la producción de los nativos.

Hamstring injury has been considered one of the most common exercise-induced injuries in sports. Hamstring injuries mostly occur proximal to the biceps femoris. However, the reasons and mechanisms remain unclear. To summarize hamstring morphological structure features and what the relationship is between their structure and risk of injury from the current literature, this review discussed the possible injury mechanism of hamstrings, from the morphological and connected pattern diversity, the mechanical properties, and the stress–strain performance, to probable changes in action control. Morphological and connected pattern diversity of hamstrings components show heterogeneous loads under muscle tension. Connections of gradient compliance between different tissues may lead to materials’ susceptibility to detachments near the tendon–bone junction sites under heterogeneous load conditions. The hamstrings muscle’s motor function insufficiency also brings the risk of injury when it performs multi-functional movements during exercise due to the span of multiple joints’ anatomical characteristics. These structural features may be the primary reason why most damage occurs near these sites. The role of these biomechanical characteristics should be appreciated by exercise specialists to effectively prevent hamstring injuries. Future work in this research should be aimed at exploring the most effective prevention programs based on the material structure and motor control to enhance the properties of hamstring muscle materials to minimize the risk of injury.

Background: This study aims to investigate the associations between dietary patterns (breakfast, egg, dairy products, and sugared beverage intake frequencies) and physical fitness among Chinese children and adolescents in Shaanxi Province. METHODS: Data were extracted from the Chinese National Survey on Students’ Constitution and Health (CNSSCH). The study ultimately included 7305 participants (48.4% male, 51.6% female) aged 6–22 in Shaanxi Province, China. Multiple linear regression was used to examine the association of the frequency of breakfast, egg, dairy product, and sugared beverage intakes with physical fitness. RESULTS: The frequency of breakfast, egg, and dairy product intakes were all independently and positively associated with the level of physical fitness. The frequency of sugared beverage intake was negatively associated with the level of physical fitness. CONCLUSION: Healthier dietary patterns (i.e., higher breakfast, egg, and dairy product intakes and lower sugared beverage intake) were associated with greater physical fitness. Specifically, maintaining a healthy dietary pattern of breakfast, egg, and dairy product intakes can positively affect the strength and endurance performance of children and adolescents. Increased dairy product intake plays a crucial part in boosting the physical fitness total scores of children and adolescents.

Abstract Since their seminal discovery in 2011, two-dimensional (2D) transition metal carbides/nitrides known as MXenes, that constitute a large family of 2D materials, have been targeted toward various applications due to their outstanding electronic properties. MXenes functioning as co-catalyst in combination with certain photocatalysts have been applied in photocatalytic systems to enhance photogenerated charge separation, suppress rapid charge recombination, and convert solar energy into chemical energy or use it in the degradation of organic compounds. The photocatalytic performance greatly depends on the composition and morphology of the photocatalyst, which, in turn, are determined by the method of preparation used. Here, we review the four different synthesis methods (mechanical mixing, self-assembly, in situ decoration, and oxidation) reported for MXenes in view of their application as co-catalyst in photocatalysis. In addition, the working mechanism for MXenes application in photocatalysis is discussed and an outlook for future research is also provided.

Background: This study aimed to explore the characteristics of trends in physical fitness and nutritional status among school-aged students during the COVID-19 pandemic, which could help to develop targeted guidelines and policies for students (adolescents) to promote health during lockdowns resulting from public health emergencies. Methods: The physical fitness and nutritional status were measured from 2019 to 2021; the correlation between years and grade were analyzed. Results: a declining trend was found in aerobic fitness, strength fitness, speed fitness, and BMI during this lockdown. Conclusion: The changes in dietary behavior and the decrease in outdoor physical activities may be the reason for the decline. Furthermore, differences in subjects’ growth and limited space at home must be considered in the formulation of exercise and nutritional plans. According to the results of our study, exercise for aerobic fitness should receive more attention when students are enduring a pandemic lockdown. In addition, saying “no” to high-calorie foods in the form of snacking and ultra-processed food was the key to improving subjects’ nutritional status.

The aim of this study was to summarize the research status and reveal the impact of mobile phone use on gait characteristics by reviewing the existing studies in terms of research status, participants, independent variables, dependent variables, main findings, etc. Twenty-nine studies which investigated the impact of using mobile phones on gait characteristics were identified through a literature search. The majority of these studies examined the effects of mobile phone use on gait characteristics in young people. The preliminary results showed that walking while using a mobile phone has significant impacts on gait. It can decrease gait velocity, cadence, step length and stride length, along with significantly increasing step width, step time and double support time. The results varied among different mobile phone usage, which resulted from the different motor and mental demands. Additionally, age and environment could affect the results as well. As well as the kinematic characteristics, we suggest that kinetic and EMG analysis are conducted in future studies.

Gas-cooled space nuclear reactor system usually utilizes the helium-xenon gas mixture as the working fluid. Since the typical helium-xenon mixture has the Prandtl number of about 0.2, which is lower than that of water and air, the turbulent flow and heat transfer features need to be further investigated among the helium-xenon mixture and other fluids. In the current paper, numerical investigations by ANSYS Fluent are performed on helium-xenon mixture flow (HeXe40, M = 40.0 g/mol, Pr = 0.21), airflow (Pr = 0.71), and water flow (Pr = 6.99) in the circular tube. Direct numerical simulation results of liquid metal flow (Pr = 0.01) are also adopted for comparison. Results show that the dimensionless velocity profile and shear stress in the boundary layer of HeXe40 are close to those of other fluids. The empirical correlations from other fluids can also predict well the friction factor of helium-xenon mixtures. Due to the discrepancy in turbulent heat diffusivity ratio, the dimensionless radial temperature profile and turbulent heat conduction of HeXe40 significantly differ from those of other fluids. The molecular conduction region of HeXe40 develops up to y+ ≈ 30 and extends to the logarithmic region of the flow boundary layer. Moreover, the available experimental Nusselt numbers of helium-xenon mixtures are compared with several convective heat transfer correlations, in which Kays correlation is better.

In the present study, visual attention processes in complex, sport-related decision-making tasks were examined. Psychophysiological and performance data recorded from 15 advanced table tennis athletes and 15 intermediate level undergraduates were compared. A total of 240 three-dimensional pictures of stimuli composed of a white ball and hitting location (black shade point) were presented via a screen, in which 25% represented side-backspin serves, and the other 75% represented non-side-topspin serves. Participants were instructed to report the types of serves. The results indicated that table tennis athletes responded more quickly and accurately. C1 and P1components were induced in the occipital region, N1 in the central region, and P3 in all regions. For table tennis athletes, in the phase of early sensory processing for stimuli features (such as hitting location), the cerebral cortex was activated at a higher level in comparison with undergraduates. This may be caused by the long-term exercise training. Athletes have to be very sensitive to the physical features of relevant movement stimuli. In the phase of recognizing stimuli structures or patterns, advanced athletes’ cerebral cortexes were activated higher and faster. This may help them more effectively match visual information about serves to patterns stored in long-term memory.

Background: Restricted outdoor activities and online learning during COVID-19 pandemic may pose threats on the physical and mental health of Chinese adolescents in middle schools. The study was to explore the relationship of Physical Activity (PA) and Sedentary Time (SED) with mood states among Chinese adolescents during the pandemic. Methods: A total of 4898 adolescents (16.3 ± 1.3 years old) from 49 middle schools in 13 urban and rural areas in Yan’an, China volunteered to participate in this study and completed online questionnaires. International Physical Activity Questionnaire (IPAQ) were used to measure PA and SED, and Profile of Mood States were used to evaluate mood states. We used Mann–Whitney U-test and Kruskal–Wallis test to assess differences in PA and SED in different sex and grade group, respectively. Mixed linear regression was used to analyze the relationship between PA/SED and mood states. Results: Participants in our study accumulated 23.4 ± 52.5 min of moderate-to-vigorous PA and 363.6 ± 148.4 min of SED per day. The mood states of boys were better than that of girls (p < 0.01). The mood states of the students in Senior High School Grade 3 were at the highest level of mood disturbance. Higher levels of PA were significantly associated with lower levels of total mood disturbance in this population (High PA group according to IPAQ: B = −3.22, SE = 0.40, p < 0.001; Moderate: B = −1.47, SE = 0.37, p < 0.001, compared to Low PA group). Conclusion: Chinese adolescents maintained a sedentary lifestyle during the COVID-19 pandemic. Girls and students in Grade 3 Senior High School had higher level of mood disturbance. More PA was associate with improving mood state among adolescents in the pandemic. The present study may assist policymakers and healthcare professionals understand PA and mood states of Chinese adolescents during the epidemic and take targeted actions in case of emergencies in future.

This work focuses on the influence of L2 acquisition environments (At-Home and Study-Abroad) on the language proficiency of L1 Mandarin Chinese learners of Spanish. We chose the use of Spanish past tense aspect (pretérito indefinido and pretérito imperfecto) as the entry point to analyze Chinese learners proficiency in three semi-guided writing tasks. Our results reveal that the different teaching objectives in these acquisition environments promote a different development of Chinese learners’ language capacities in Spanish: the At-Home learners have a more native-like performance when factors at the discourse level are taken into account, whereas the Study-Abroad learners have a more native-like performance when factors at the lexical level are taken into account. However, the usage pattern of the Spanish past tense aspect by learners in both environments share prototypical associations at the lexical and discourse levels.

Abstract Typically, relief generation from an input 3D scene is limited to either bas-relief or high-relief modeling. This paper presents a novel unified scheme for synthesizing reliefs guided by the geometric texture richness of 3D scenes; it can generate both basand high-reliefs. The type of relief and compression coefficient can be specified according to the user’s artistic needs. We use an energy minimization function to obtain the surface reliefs, which contains a geometry preservation term and an edge constraint term. An edge relief measure determined by geometric texture richness and edge z-depth is utilized to achieve a balance between these two terms. During relief generation, the geometry preservation term keeps local surface detail in the original scenes, while the edge constraint term maintains regions of the original models with rich geometric texture. Elsewhere, in highreliefs, the edge constraint term also preserves depth discontinuities in the higher parts of the original scenes. The energy function can be discretized to obtain a sparse linear system. The reliefs are obtained by solving it by an iterative process. Finally, we apply non-linear compression to the relief to meet the user’s artistic needs. Experimental results show the method’s effectiveness for generating both bas- and high-reliefs for complex 3D scenes in a unified manner.

Recently, menstrual blood-derived endometrial stem cells (MenSCs) have become attractive for stem cell based therapy due to their abundance, easy and non-invasive extraction and isolation process, high proliferative capacity, and multi-lineage differentiation potential. MenSC-based therapies for various diseases are being extensively researched. However, the high death rate and poor engraftment in sites of damaged tissues reduce the therapeutic value of these stem cells for transplantation. In theory, periodic stem cell transplantation is an alternative strategy to overcome the challenge of the loss of beneficial stem cell-derived effects due to the rapid disappearance of the stem cells in vivo. However, periodic stem cell transplantation requires sufficient amounts of the desired stem cells with a low number of subculture passages. Our previous results have demonstrated that primary MenSCs mainly reside in the deciduous endometrium, and considerable amounts of deciduous endometrium intertwined with menstrual blood clots were discarded after conventional density gradient centrifugation (DGC). Therefore, the aim of this study was to determine whether primary MenSCs exist in the sedimentation of the deciduous endometrium after DGC and further to evaluate the isolation of MenSCs by direct red blood cell lysis treatment. As expected, our results confirmed that substantial amounts of primary MenSCs still remain in the sedimentation after DGC and indicated that MenSC isolation by directly lysing the red blood cells not only guaranteed substantial amounts of superior MenSCs with a low number of subculture passages, but also was time efficient and economical, providing a solid support for extensive clinical application.

Este trabajo se centra en la adquisición del pretérito indefinido y el pretérito imperfecto del español por aprendices chinos. A partir de investigaciones anteriores, predecimos que las diferencias del sistema aspectual entre el chino mandarín y el español pueden suponer un reto para los aprendices en el uso y comprensión del aspecto en la interlengua. Además, creemos que la adquisición del aspecto no está sincronizada en el nivel morfológico y semántico. A través de una prueba de gramatical y una de comprensión, descubrimos que las diferencias de los sistemas aspectuales entre la L1 y la L2 causan dificultad en los aprendices. Asimismo, nuestros datos apoyan que la adquisición del aspecto en el nivel morfológico ocurre más temprano que la adquisición en el nivel semántico.

With an increase in rural-to-urban migration, a rapidly aging population, and the rising risk of developing noncommunicable diseases in China, it is important to understand the epidemiology of physical activity (PA) and health in the context of disease prevention and population health. Despite its public health importance, there is a significant lack of knowledge about PA in older Chinese adults that may hamper primary prevention efforts of health promotion in an increasingly aging population. To fill this gap, this article presents a narrative review of PA in the older Chinese adult population with a special focus on residential settings (i.e., urban and rural). Using existing studies, the review examines overall PA patterns and their correlates and discusses public health implications and future research. Although there are some preliminary indications of urban and rural differences in PA in the aging population in China, continued research efforts are needed to facilitate primary prevention efforts aimed at reducing noncommunicable diseases and promoting an active lifestyle among the largest population of older people in the world.

The pebble-bed reactor HTR-PM is being built in China and is planned to be critical in one or two years. At present, one emphasis of engineering design is to determine the fuel management scheme of the initial core and running-in phase. There are many possible schemes, and many factors need to be considered in the process of scheme evaluation and analysis. Based on the experience from the constructed or designed pebble-bed reactors, the fuel enrichment and the ratio of fuel spheres to graphite spheres are important. In this paper, some relevant physical considerations of the initial core and running-in phase of HTR-PM are given. Then a typical scheme of the initial core and running-in phase is proposed and simulated with VSOP code, and some key physical parameters, such as the maximum power per fuel sphere, the maximum fuel temperature, the refueling rate, and the discharge burnup, are calculated. Results of the physical parameters all satisfy the relevant design requirements, which means the proposed scheme is safe and reliable and can provide support for the fuel management of HTR-PM in the future.

Down’s syndrome (DS), the most common genetic cause of significant intellectual disability in children and adults is caused by the trisomy of either all or a part of human chromosome 21 (HSA21). Patients with DS mostly suffer from characteristic tumor types. Although individual patients of DS are at a higher risk for acute leukemia and testicular cancers, other types of solid tumors including breast cancers are mostly uncommon and have significantly lower-than-expected age-adjusted incidence rates. Except for an increased risk of retinoblastomas, and lymphomas, the risk of developing solid tumors has been found to be lower in both children and adults, and breast cancer was found to be almost absent (Hasle H., The Lancet Oncology, 2001). A study conducted in the United States found only one death when 11.65 were expected (Scholl T et al., Dev Med Child Neurol. 1982). A recent study examined mammogram reports of women with DS treated in the largest medical facility specifically serving adults with DS in the United States. It was found that only 0.7% women with DS had been diagnosed with breast cancers (Chicoine B et al., Intellect Dev Disabil. 2015). Here we describe a case of breast cancer in a 25-year-old patient with DS. The disease was presented as lymph node positive carcinoma with alterations of tumor suppressor genes characteristic to the triple negative breast cancer subtype. Comprehensive Genomic Profiling (CGP) revealed a wild-type status for BRCA1. The CGP report showed a frameshift mutation, A359fs*10 of the tumor suppressor gene INPP4B and another frameshift mutation, R282fs*63 of tumor suppressor gene TP53 in the tumor biopsy as characteristically found in triple-negative breast cancers. The VUS (Variance of Unknown Significance) alteration(s) were identified in ASXL1 (L1395V), NTRK1 (G18E), DDR2 (I159T), RUNX1 (amplification), ERG (amplification), SOX2 (T26A), FAM123B (G1031D), and HNF1A (A301T). Bonafide cancer-related genes of chromosome 21 amplified in the patient’s tumor are RUNX1 and ERG genes. After the completion of the radiation, the patient was placed on everolimus which was based on the result of her CGP report. Thus, post-mastectomy radiation therapy was completed with a recommendation for everolimus for one year. During the time of writing of this report, no metastatic lesions were identified. The patient currently has no evidence of disease.