1. The ability of biomarkers to assess the severity of atopic dermatitis
- Author
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Takeshi Nakahara, MD, PhD, Daisuke Onozuka, PhD, Satoshi Nunomura, PhD, Hidehisa Saeki, MD, PhD, Motoi Takenaka, MD, PhD, Mai Matsumoto, MD, PhD, Yoko Kataoka, MD, Rai Fujimoto, MD, PhD, Sakae Kaneko, MD, PhD, Eishin Morita, MD, PhD, Akio Tanaka, MD, PhD, Ryo Saito, MD, PhD, Tatsuro Okano, MD, PhD, Tomomitsu Miyagaki, MD, PhD, Natsuko Aoki, MD, PhD, Kimiko Nakajima, MD, PhD, Susumu Ichiyama, MD, PhD, Makiko Kido-Nakahara, MD, PhD, Kyoko Tonomura, MD, PhD, Yukinobu Nakagawa, MD, PhD, Risa Tamagawa-Mineoka, MD, PhD, Koji Masuda, MD, PhD, Takuya Takeichi, MD, PhD, Masashi Akiyama, MD, PhD, Yozo Ishiuji, MD, PhD, Michie Katsuta, MD, PhD, Yuki Kinoshita, MD, PhD, Chiharu Tateishi, MD, PhD, Aya Yamamoto, MD, PhD, Akimichi Morita, MD, PhD, Haruna Matsuda-Hirose, MD, PhD, Yutaka Hatano, MD, PhD, Hiroshi Kawasaki, MD, PhD, Ayano Fukushima-Nomura, MD, Mamitaro Ohtsuki, MD, PhD, Koji Kamiya, MD, PhD, Yudai Kabata, MD, PhD, Riichiro Abe, MD, PhD, Hiroshi Mitsui, MD, PhD, Tatsuyoshi Kawamura, MD, PhD, Gaku Tsuji, MD, PhD, Norito Katoh, MD, PhD, Masutaka Furue, MD, PhD, and Kenji Izuhara, MD, PhD
- Subjects
Atopic dermatitis ,biomarker ,B-PAD ,Biomarkers to Predict Clinical Improvement of AD in Patients Treated With Dupilumab ,EASI ,eotaxin-3 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out the Biomarkers to Predict Clinical Improvement of AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study in Japan, to explore biomarkers for AD. Objective: The aim of this study is to find biomarkers associated with objective and subjective clinical findings in patients with moderate-to-severe AD based on the B-PAD study and to identify biomarkers sensitive enough to assess the severity of AD. Methods: We performed the B-PAD study as a consortium composed of 19 medical facilities in Japan, enrolling 110 patients with moderate-to-severe AD. We evaluated the Eczema Area and Severity Index (EASI) for objective assessment as well as the Patient-Oriented Eczema Measure (POEM) and a numeric rating scale for pruritus (pruritis-NRS) for subjective assessment, measuring 19 biomarkers at baseline. Results: We found that 12, 6, and 7 biomarkers showed significant and positive associations with the EASI, POEM, and pruritis-NRS, respectively. Most of the biomarkers associated with either the POEM or the pruritis-NRS were included among the biomarkers associated with EASI. Of the biomarkers examined, CCL26/eotaxin-3 and SCCA2 were the most capable of assessing severity for EASI, as shown by the 2 kinds of receiver operating characteristic analyses, respectively, whereas lactate dehydrogenase was the best for both the POEM and pruritis-NRS, again using the 2 analyses. Conclusion: We found biomarkers associated with the EASI, POEM, and pruritis-NRS, respectively, based on the B-PAD study. Moreover, we identified CCL26/eotaxin-3 and/or SCCA2 as the biomarkers having the greatest ability to assess severity in the EASI; lactate dehydrogenase did the same for the POEM and pruritis-NRS. These findings will be useful in treating patients with moderate-to-severe AD.
- Published
- 2024
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