234 results on '"Yuji, Hashimoto"'
Search Results
2. Efficient Supersingularity Testing of Elliptic Curves Using Legendre Curves.
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Yuji Hashimoto and Koji Nuida
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- 2023
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Catalog
3. Effects of repetition exercise training on vascular endothelial function in healthy men
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Yasuaki Tamura, Hajime Miura, Kenichi Deguchi, Yuji Hashimoto, Junji Deguchi, Ayako Murakami, and Mizuki Ishikawa
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repetition training ,vascular endothelium ,exercise ,vasodilation ,Sports medicine ,RC1200-1245 ,Physiology ,QP1-981 - Abstract
High-intensity interval training improves the vascular endothelial function better than moderate-intensity continuous training. However, few studies have examined the effects of repetition training consisting of high-intensity exercise, followed by complete rest, on arterial function. We performed this study to investigate the effects of repetition training of high-intensity exercise on the vascular endothelial function determined by flow-mediated vasodilation. Twenty healthy male participants were randomized and stratified into two training groups, one group performed moderate-intensity continuous training (n = 10) while another performed repetition training of high-intensity exercise (n = 10). Both groups exercised 3 times a week for 6 weeks. Before and after each training protocol, the vascular endothelial function of the right brachial artery was assessed by flow-mediated vasodilation. In the moderate-intensity continuous training group, flow-mediated vasodilation changed 9.92 ± 2.45% to 10.58 ± 2.93% (ns). In the repetition training of high-intensity exercise group, flow-mediated vasodilation changed 7.26 ± 1.46% to 8.58 ± 1.22% (p < 0.05). A greater increase in vascular endothelial function was observed in high-intensity repetition training compared to moderate-intensity continuous training. These results suggest the possible effect of repetition training on the prevention of cardiovascular disease. more...
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- 2022
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4. Tight Security of Twin-DH Hashed ElGamal KEM in Multi-User Setting.
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Yuji Hashimoto, Koji Nuida, and Goichiro Hanaoka
- Published
- 2022
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5. Improved Supersingularity Testing of Elliptic Curves Using Legendre Form.
- Author
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Yuji Hashimoto and Koji Nuida
- Published
- 2021
- Full Text
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6. Improved supersingularity testing of elliptic curves.
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Yuji Hashimoto and Katsuyuki Takashima
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- 2021
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7. Secure Grouping Protocol Using a Deck of Cards.
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Yuji Hashimoto, Kazumasa Shinagawa, Koji Nuida, Masaki Inamura, and Goichiro Hanaoka
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- 2017
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8. Secure Grouping Protocol Using a Deck of Cards.
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Yuji Hashimoto, Kazumasa Shinagawa, Koji Nuida, Masaki Inamura, and Goichiro Hanaoka
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- 2018
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9. Toward Finite-Runtime Card-Based Protocol for Generating a Hidden Random Permutation without Fixed Points.
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Yuji Hashimoto, Koji Nuida, Kazumasa Shinagawa, Masaki Inamura, and Goichiro Hanaoka
- Published
- 2018
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10. Cardiovascular Outcomes in Patients With Previous Myocardial Infarction and Mild Diabetes Mellitus Following Treatment With Pioglitazone
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Masanori Asakura, Jiyoong Kim, Hiroshi Asanuma, Yasuharu Nakama, Kengo Tsukahara, Yorihiko Higashino, Tetsuya Ishikawa, Shinji Koba, Mitsuru Tsujimoto, Hideo Himeno, Yasuyuki Maruyama, Takanori Ookusa, Shunichi Yoda, Hiroshi Suzuki, Shinji Okubo, Makoto Shimizu, Yuji Hashimoto, Kazuo Satake, Susumu Fujino, Hiroyasu Uzui, Yoshiyuki Nagai, Tohru Kohno, Sumio Mizuno, Makoto Nakahama, Hounin Kanaya, Toyoaki Murohara, Kazuki Fukui, Hiroyuki Takase, Nobuyuki Ohte, Takaaki Shiono, Masatake Fukunami, Tsutomu Endo, Reimin Sawada, Kenshi Fujii, Motoshi Takeuchi, Shuntaro Ikeda, Koichi Mizuno, Masaaki Uematsu, Taku Matsubara, Shoji Yano, Jun Takahashi, Kousei Ueda, Yoshihiko Kinoshita, Koichi Tamita, Hideki Hayashi, Toshimitsu Hamasaki, and Masafumi Kitakaze more...
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Medicine (General) ,R5-920 - Abstract
Background: Secondary prevention in patients with myocardial infarction (MI) is critically important to prevent ischaemic heart failure and reduce social burden. Pioglitazone improves vascular dysfunction and prevents coronary atherosclerosis, mainly via anti-inflammatory and antiatherogenic effects by enhancing adiponectin production in addition to antihyperglycemic effects, thus suggesting that pioglitazone attenuates cardiovascular events in patients with mild (HbA1c levels more...
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- 2018
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11. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration
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Takeru Honda, Ken Matsumura, Yuji Hashimoto, Takanori Yokota, Hidehiro Mizusawa, Soichi Nagao, and Kinya Ishikawa
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Neurology ,Neurology (clinical) - Abstract
Ataxia and impaired motor learning are both fundamental features in diseases affecting the cerebellum. However, it remains unclarified whether motor learning is impaired only when ataxia clearly manifests, nor it is known whether the progression of ataxia, the speed of which often varies among patients with the same disease, can be monitored by examining motor learning. We evaluated motor learning and ataxia at intervals of several months in 40 patients with degenerative conditions [i.e., multiple system atrophy (MSA), Machado–Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3), SCA6, and SCA31]. Motor learning was quantified as the adaptability index (AI) in the prism adaptation task and ataxia was scored using the Scale for the Assessment and Rating of Ataxia (SARA). We found that AI decreased most markedly in both MSA-C and MSA-P, moderately in MJD, and mildly in SCA6 and SCA31. Overall, the AI decrease occurred more rapidly than the SARA score increase. Interestingly, AIs remained normal in purely parkinsonian MSA-P patients (n = 4), but they dropped into the ataxia range when these patients started to show ataxia. The decrease in AI during follow-up (dAI/dt) was significant in patients with SARA scores AI is particularly useful for diagnosing the earlier phase of cerebellar degeneration. We conclude that AI is a useful marker for progressions of cerebellar diseases, and that evaluating the motor learning of patients can be particularly valuable for detecting cerebellar impairment, which is often masked by parkinsonisms and other signs. more...
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- 2023
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12. Kaplan–Meier survival analysis and Cox regression analyses regarding right ventricular septal pacing: Data from Japanese pacemaker cohort
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Akira Mizukami, Yuya Matsue, Yoshihisa Naruse, Shinya Kowase, Kenji Kurosaki, Makoto Suzuki, Akihiko Matsumura, Akihiko Nogami, Kazutaka Aonuma, and Yuji Hashimoto
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
The presented data were obtained from 982 consecutive patients receiving their first pacemaker implantation with right ventricular (RV) lead placement between January 2008 and December 2013 at two centers in Japan. Patients were divided into RV apical and septal pacing groups. Data of Kaplan–Meier survival analysis and Cox regression analysis are presented. Refer to the research article “Implications of right ventricular septal pacing for medium-term prognosis: propensity-matched analysis” (Mizukami et al., in press) [1] for further interpretation and discussion. Keywords: RV septal pacing, RV non-apical pacing, Prognosis, Heart failure, Mortality, Data more...
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- 2016
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13. A multicenter observational study of the effectiveness of antiarrhythmic agents in ventricular arrhythmias: A propensity-score adjusted analysis
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Makoto Suzuki, Wataru Nagahori, Akira Mizukami, Akihiko Matsumura, and Yuji Hashimoto
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Ventricular tachycardia ,Amiodarone ,Nifekalant ,Lidocaine ,Propensity score ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise. Recurrence is common and may worsen a patient׳s clinical course despite appropriate treatment. This study aimed to examine the effectiveness of antiarrhythmic drugs for suppression of VTs. Methods: In this cohort study, eligible patients were those who were admitted to one of the nine cardiovascular care centers and treated with continuous infusion of an antiarrhythmic drug for at least 1 h to prevent recurrence of VTs after return of spontaneous circulation. To adjust for differences in baseline characteristics among treatment groups, propensity scores for administered agents were generated and used as covariates in regression analyses. Results: Seventy-two patients were enrolled and 67 patients were included in the final analysis. Amiodarone (n=21, 31.3%), nifekalant (n=24, 35.8%), and lidocaine (n=22, 32.8%) were administered as first-line therapy for suppression of VTs. In the adjusted analyses, the odds ratio (OR) of switching to a different drug was significantly higher in the lidocaine group (OR 37.6, 95% CI 5.1–279, p more...
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- 2016
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14. Tight Security of Twin-DH Hashed ElGamal KEM in Multi-User Setting
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Koji Nuida, Goichiro Hanaoka, and Yuji Hashimoto
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Computer science ,business.industry ,Applied Mathematics ,Signal Processing ,Electrical and Electronic Engineering ,Multi-user ,business ,Computer Graphics and Computer-Aided Design ,ElGamal encryption ,Computer network - Published
- 2022
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15. Histological examination of the right atrial appendage after failed catheter ablation for focal atrial tachycardia complicated by cardiogenic shock in a post-partum patient
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Akira Mizukami, MD, Makoto Suzuki, MD, Rena Nakamura, MD, Shunsuke Kuroda, MD, Maki Ono, MD, Yuya Matsue, MD, Ryota Iwatsuka, MD, Taishi Yonetsu, MD, Akihiko Matsumura, MD, and Yuji Hashimoto, MD
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Right atrial appendage ,Atrial tachycardia ,Pregnancy ,Cardiogenic shock ,Histology ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
A 26-year-old woman in her first pregnancy presented with persistent atrial tachycardia (AT). AT was resistant to medications, cardioversions, and the first attempt of catheter ablation. Two months after delivery she developed severe systolic dysfunction and circulatory collapse. Emergent catheter ablation was performed with the support of percutaneous cardiopulmonary bypass and intraaortic balloon pump. The AT originated in the apex of the right atrial appendage (RAA). Repeated attempts at ablation were unsuccessful, prompting surgical RAA resection, which terminated the tachycardia and improved the cardiac function. Histological examination of resected RAA provided insights into mechanism of resistance to catheter ablation. more...
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- 2016
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16. Improved supersingularity testing of elliptic curves
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Katsuyuki Takashima and Yuji Hashimoto
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Elliptic curve ,Mathematical analysis ,General Engineering ,Mathematics - Published
- 2021
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17. Asymptomatic cerebral findings on 3-Tesla MRI in patients with severe carotid artery stenoses
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Shoichi Komura, Tatsufumi Nomura, Toshio Imaizumi, Shigeru Inamura, Aya Kanno, Osamu Honda, Yuji Hashimoto, Takeshi Mikami, and Tadashi Nonaka
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Adult ,General Medicine ,Constriction, Pathologic ,Magnetic Resonance Imaging ,Stroke ,Neurology ,Physiology (medical) ,Cerebral Small Vessel Diseases ,Stroke, Lacunar ,Humans ,Surgery ,Carotid Stenosis ,Female ,Neurology (clinical) ,Aged ,Cerebral Hemorrhage ,Retrospective Studies - Abstract
Small vessel diseases (SVDs) are often asymptomatic. However, SVDs significantly influence the prognosis in patients with large vessel diseases (LVDs). We investigated asymptomatic cerebral findings on 3-Tesla MRI in patients with severe carotid artery (CA) stenoses, compared to peoples without a past history of neurological disorders, including strokes.We retrospectively analyzed the prevalences of various asymptomatic cerebral findings which were intracerebral hemorrhages (ICHs), cortical superficial siderosis, ventricular dilatation (Evans' index) and SVDs including cerebral microbleeds (CMBs), lacunar infarctions (LIs), deep white matter hyperintensities (WMHs), periventricular hyperintensities (PVHs). The prevalence of each finding was compared using multivariate logistic regression models with adjustment for stroke risk factors.We evaluated the findings in 54 patients with severe CA stenosis treated by stenting (CA stenosis group) and 200 adults with health screening tests of the brain and no past history of neurological disorders (control group). Multivariate analyses adjusted for age ≥ 65 years old, female gender, hypertension, hyperlipidemia, diabetes mellitus, alcohol consumption, and smoking index revealed that the prevalences of severe PVHs, severe deep WMHs, asymptomatic deep ICHs, and asymptomatic LIs were significantly higher in the CA stenosis group than the control group. However, there were no significant differences in the prevalences of CMBs, or the remaining asymptomatic findings described above.With pathological differences between SVD and LVD, asymptomatic SVDs except CMBs and deep ICHs often co-exists severe CA stenosis as a presentative LVD. more...
- Published
- 2021
18. Suppression of Ventricular Tachycardia Associated with Cardiac Sarcoidosis by Steroid Therapy
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Kotaro Miyaji, MD, Makoto Suzuki, MD, Akira Mizukami, MD, Ryota Iwatsuka, MD, Reon Kumasaka, MD, Naoaki Ichihara, MD, Wataru Nagahori, MD, Masakazu Oono, MD, Tetsuo Arakawa, MD, Nobuyuki Masaki, MD, Akihiko Matsumura, MD, and Yuji Hashimoto, MD more...
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Cardiac sarcoidosis ,Ventricular tachycarida ,Steroid therapy ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
In patients with cardiac sarcoidosis, ventricular tachycardia (VT) is observed in some cases. However, effective therapies for the VT are still unknown. Case: A 50-year old female with cardiac sarcoidosis underwent DDD pacemaker implantation for a high degree atrioventricular block with symptoms of faintness and shortness of breath. One month after the surgery, she was admitted for frequent episodes of non-sustained VT. In the electrophysiologic study (EPS), sustained monomorphic VT and ventricular fibrillation were induced; therefore pacemaker was replaced with implantable cardioverter-defibrillator (ICD). Amiodarone was started orally but it couldn't suppress frequent VT episodes, and frequent ICD shocks were delivered. When the oral steroid therapy was initiated for the cardiac sarcoidosis, it not only suppressed the frequent VT but also improved the atrioventricular nodal dysfunction. In conclusion, steroid therapy might be an option to consider in cardiac sarcoidosis with refractory VT. more...
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- 2007
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19. Quantitative evaluation of human cerebellum-dependent motor learning through prism adaptation of hand-reaching movement.
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Yuji Hashimoto, Takeru Honda, Ken Matsumura, Makoto Nakao, Kazumasa Soga, Kazuhiko Katano, Takanori Yokota, Hidehiro Mizusawa, Soichi Nagao, and Kinya Ishikawa
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Medicine ,Science - Abstract
The cerebellum plays important roles in motor coordination and learning. However, motor learning has not been quantitatively evaluated clinically. It thus remains unclear how motor learning is influenced by cerebellar diseases or aging, and is related with incoordination. Here, we present a new application for testing human cerebellum-dependent motor learning using prism adaptation. In our paradigm, the participant wearing prism-equipped goggles touches their index finger to the target presented on a touchscreen in every trial. The whole test consisted of three consecutive sessions: (1) 50 trials with normal vision (BASELINE), (2) 100 trials wearing the prism that shifts the visual field 25° rightward (PRISM), and (3) 50 trials without the prism (REMOVAL). In healthy subjects, the prism-induced finger-touch error, i.e., the distance between touch and target positions, was decreased gradually by motor learning through repetition of trials. We found that such motor learning could be quantified using the "adaptability index (AI)", which was calculated by multiplying each probability of [acquisition in the last 10 trials of PRISM], [retention in the initial five trials of REMOVAL], and [extinction in the last 10 trials of REMOVAL]. The AI of cerebellar patients less than 70 years old (mean, 0.227; n = 62) was lower than that of age-matched healthy subjects (0.867, n = 21; p < 0.0001). While AI did not correlate with the magnitude of dysmetria in ataxic patients, it declined in parallel with disease progression, suggesting a close correlation between the impaired cerebellar motor leaning and the dysmetria. Furthermore, AI decreased with aging in the healthy subjects over 70 years old compared with that in the healthy subjects less than 70 years old. We suggest that our paradigm of prism adaptation may allow us to quantitatively assess cerebellar motor learning in both normal and diseased conditions. more...
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- 2015
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20. Influence of repetition exercise requiring less work than continuous exercise on the vascular endothelial function
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Mizuki Ishikawa, Ayako Azuma, Yuji Hashimoto, Kenichi Deguchi, Hajime Miura, and Yasuaki Tamura
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medicine.medical_specialty ,Physical medicine and rehabilitation ,Repetition (rhetorical device) ,business.industry ,media_common.quotation_subject ,Work (physics) ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,business ,Function (engineering) ,media_common - Published
- 2019
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21. A Case of Delayed Symptomatic Vasospasm after Surgical Clipping of an Unruptured Intracranial Aneurysm
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Akira Takahashi, Masahiko Daibo, Yasuyuki Yonemasu, Yuji Hashimoto, Tadashi Nonaka, Osamu Honda, Tatsufumi Nomura, and Toshiyuki Onda
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medicine.medical_specialty ,Aneurysm ,Surgical clipping ,business.industry ,medicine ,Symptomatic vasospasm ,medicine.disease ,business ,Surgery - Published
- 2019
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22. Two-dimensional distribution measurement of in-plane velocity component using bias-frequency spatial encoding
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Koichi Maru, Yuji Hashimoto, and Sayyidatul Nur Afiqah binti Abd Ghafar
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Physics ,Optical engineering ,Acoustics ,General Engineering ,Laser Doppler velocimetry ,Measure (mathematics) ,Atomic and Molecular Physics, and Optics ,law.invention ,symbols.namesake ,Interferometry ,law ,Component (UML) ,symbols ,Doppler effect ,Beam splitter ,Beam (structure) - Abstract
We propose a differential laser Doppler velocimeter (LDV) for two-dimensional (2D) distribution measurements of the in-plane velocity component based on bias-frequency spatial encoding. Using two crossing beam arrays, the structure can effectively assign bias frequencies to the measurement points over a 2D area. As a feasibility study of the proposed method, velocity distribution measurements were conducted using a 4 × 4-channel optical setup. The experimental results indicate that the proposed method could successfully measure the 2D distribution of the in-plane velocity component. more...
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- 2021
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23. Improved Supersingularity Testing of Elliptic Curves Using Legendre Form
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Koji Nuida and Yuji Hashimoto
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Isogeny ,Elliptic curve ,Legendre form ,Square root ,Deterministic algorithm ,Computation ,Applied mathematics ,Supersingular elliptic curve ,nth root ,Mathematics - Abstract
There are two types of elliptic curves, ordinary elliptic curves and supersingular elliptic curves. In 2012, Sutherland proposed an efficient and almost deterministic algorithm for determining whether a given curve is ordinary or supersingular. Sutherland’s algorithm is based on sequences of isogenies started from the input curve, and computation of each isogeny requires square root computations, which is the dominant cost of the algorithm. In this paper, we reduce this dominant cost of Sutherland’s algorithm to approximately a half of the original. In contrast to Sutherland’s algorithm using j-invariants and modular polynomials, our proposed algorithm is based on Legendre form of elliptic curves, which simplifies the expression of each isogeny. Moreover, by carefully selecting the type of isogenies to be computed, we succeeded in gathering square root computations at two consecutive steps of Sutherland’s algorithm into just a single fourth root computation (with experimentally almost the same cost as a single square root computation). The results of our experiments using Magma are supporting our argument; for cases of characteristic p of 768-bit to 1024-bit lengths, our algorithm runs 43.6% to 55.7% faster than Sutherland’s algorithm. more...
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- 2021
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24. Toward Finite-Runtime Card-Based Protocol for Generating a Hidden Random Permutation without Fixed Points
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Masaki Inamura, Koji Nuida, Kazumasa Shinagawa, Goichiro Hanaoka, and Yuji Hashimoto
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Computer science ,Applied Mathematics ,0102 computer and information sciences ,02 engineering and technology ,Fixed point ,Random permutation ,01 natural sciences ,Computer Graphics and Computer-Aided Design ,010201 computation theory & mathematics ,Signal Processing ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Electrical and Electronic Engineering ,Algorithm ,Protocol (object-oriented programming) - Published
- 2018
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25. Critical velocity and backlayering distance in tunnel fires with longitudinal ventilation taking thermal properties of wall materials into consideration
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Khalid Moinuddin, Kohei Takezawa, Yuji Hashimoto, and Futoshi Tanaka
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Reference data (financial markets) ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Building and Construction ,Mechanics ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Geotechnical Engineering and Engineering Geology ,Critical ionization velocity ,Thermal conduction ,0201 civil engineering ,law.invention ,Tunnel wall ,law ,Condensed Matter::Superconductivity ,Ventilation (architecture) ,Thermal ,Scale model ,Scaling ,Geology ,021101 geological & geomatics engineering - Abstract
A set of tunnel fire experiments using a 1:20 scale model tunnel was conducted taking into account the scaling of heat conduction through the tunnel walls. The critical velocity and backlayering distance measured in the tunnel fire experiments were compared with other reference data to examine the effect of the thermal properties of the tunnel walls on these two parameters. In this paper, we present new correlations for estimating the critical velocity and backlayering distance, and discuss the difference between our correlations and the previous ones from the viewpoint of the thermal properties of the tunnel wall materials. more...
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- 2018
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26. Arterial inflammation measured by 18F-FDG-PET-CT to predict coronary events in older subjects
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Akihiko Matsumura, Yuji Hashimoto, Toshihiro O'uchi, Ryota Iwatsuka, Yuya Matsue, Kenzo Hirao, and Taishi Yonetsu
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medicine.medical_specialty ,Framingham Risk Score ,business.industry ,Hazard ratio ,Cancer ,030204 cardiovascular system & hematology ,medicine.disease ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Internal medicine ,medicine.artery ,Ascending aorta ,medicine ,Cardiology ,Fdg pet ct ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Arterial Inflammation ,Artery - Abstract
Background and aims Although 18F-fluorodeoxyglucose (FDG) uptake has emerged as a sensitive and reliable marker of atherosclerotic inflammation, its additive predictive value for future coronary disease in older subjects is unknown. The aim of this study was to test the prognostic value of aortic inflammation detected via FDG-positron emission tomography (PET)-computed tomography (CT) in older subjects. Methods We retrospectively utilized the records of 309 subjects aged over 65 years, without a history of coronary artery disease, who underwent 18F-FDG-PET-CT mostly due to the clinical suspicion of cancer, but eventually turned out to be cancer-free. Target-to-background ratio (TBR) was calculated at the ascending aorta. The endpoint was occurrence of coronary heart disease (CHD) events. Results During a median follow-up of 3.9 years, 28 subjects experienced CHD events and 12 patients died due to non-CHD causes. The highest TBR tertile was associated with a high CHD event rate, accounting for death due to non-CHD causes as a competing risk (Gray test, p = 0.005). In a Fine and Gray competing risk proportional hazard regression model, TBR was associated with significantly high CHD events independently of FRS, with a hazard ratio (HR) of 1.19 per 0.1 TBR increase (p Conclusions In older subjects with no history of malignant disease or overt coronary artery disease, arterial inflammation evaluated by FDG uptake provides information on future occurrence of coronary artery events. more...
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- 2018
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27. Interactive specification and data schema for picture painting process.
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Yuji Hashimoto, Takeshi Murano, Yo Murao, and Hajime Enomoto
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- 1993
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28. Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects
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Mamut Rayle, Takanori Yokota, Hidehiro Mizusawa, Miwa Higashi, Yajun Hu, Kazumasa Soga, Michi Okita, Kinya Ishikawa, Takashi Ishii, Yuji Hashimoto, Kokoro Ozaki, and Nozomu Sato
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Adult ,0301 basic medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,Ataxia ,Adolescent ,Biology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Japan ,Prevalence ,medicine ,Humans ,Age of Onset ,Allele ,Spinocerebellar Degenerations ,Sequence (medicine) ,Genetics ,Middle Aged ,medicine.disease ,Penetrance ,030104 developmental biology ,Neurology ,Spinocerebellar ataxia ,RNA, Long Noncoding ,Neurology (clinical) ,Age of onset ,medicine.symptom ,Trinucleotide Repeat Expansion ,Trinucleotide repeat expansion ,030217 neurology & neurosurgery - Abstract
Spinocerebellar ataxia type 8 (SCA8), an autosomal dominant neurodegenerative disorder showing slowly progressive cerebellar ataxia, is caused by a tri-nucleotide CTG repeat expansion (CTGexp) in the SCA8 gene. As the CTGexp is not fully penetrant, the significance of screening CTGexp in ataxia subjects remains obscure. We tested SCA8 CTGexp in a cohort of 797 ataxia subjects, and if present, its sequence configuration was analyzed. CTGexp was found in 16 alleles from 14 individuals, 2 of which was homozygous for CTGexp. Nucleotide sequencing disclosed 3 types of CTGexp sequence configurations: uninterrupted CTGexp, tri-nucleotide CTA interruption and CCG interruption. The 2 individuals with homozygous expansions were both sporadic cases with clinical features compatible with SCA8, supporting gene dosage effect. Seven out of 14 CTGexp-positive subjects were also carriers of other SCA expansions [Machado-Joseph disease (n=1), SCA6 (n=3) and SCA31 (n=3)], whereas 7 others were not complicated with such major SCAs. Ages of onset in subjects with pure CTGexp tended to be earlier than those with interrupted CTGexp among the 7 subjects not complicated by major SCAs, suggesting that pure CTGexp have stronger pathogenic effect than interrupted CTGexps. The present study underscores importance of disclosing sequence configuration when testing SCA8. more...
- Published
- 2017
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29. Effects of acute aerobic repetition exercise on the vascular endothelial function
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Yuji Hashimoto, Kenichi Deguchi, Ayako Azuma, Yasuaki Tamura, Miduki Ishikawa, and Hajime Miura
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medicine.medical_specialty ,Repetition (rhetorical device) ,business.industry ,Physical Therapy, Sports Therapy and Rehabilitation ,Function (mathematics) ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Cardiology ,Physical therapy ,Orthopedics and Sports Medicine ,business ,030217 neurology & neurosurgery - Published
- 2017
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30. Discordance between subjective and objective evaluations of cognitive function in old Japanese patients with heart failure
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Miki Hirano, Akihiko Matsumura, Yoshiko Endo, Makoto Suzuki, Hiromi Iizuka, Yuji Hashimoto, Kentaro Kamiya, Kumi Takanashi, Yuya Matsue, Yuki Hasegawa, Yuri Negishi, and Hiroshi Saito
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Male ,Pediatrics ,medicine.medical_specialty ,Hospitalized patients ,Severity of Illness Index ,03 medical and health sciences ,Cognition ,Patient Admission ,Asian People ,Japan ,Older patients ,Predictive Value of Tests ,030502 gerontology ,medicine ,Humans ,Cognitive Dysfunction ,Cognitive impairment ,Geriatric Assessment ,Aged ,Retrospective Studies ,Aged, 80 and over ,Heart Failure ,Observer Variation ,Community and Home Care ,Inpatients ,business.industry ,Reproducibility of Results ,General Medicine ,Mental Status and Dementia Tests ,medicine.disease ,Confidence interval ,Cognitive Aging ,Heart failure ,Female ,Geriatrics and Gerontology ,0305 other medical science ,business - Abstract
OBJECTIVES Although cognitive impairment is common among patients with chronic heart failure (HF), the accuracy with which caregivers can recognize it is unknown. This study aimed to examine the degree to which subjective and objective evaluations coincide. METHODS Cognitive function was evaluated subjectively and objectively in 184 hospitalized patients aged 65 or older (82 ± 7.2 years old and 49% male) with HF, who were divided into three groups: (i) normal; (ii) mild cognitive impairment; and (iii) severe cognitive impairment. RESULTS The intrapatient agreement of the results of subjective and objective evaluations was tested, and weighted κ coefficients showed poor agreement (0.54, 95% confidence interval: 0.42-0.66, P < 0.001). CONCLUSION Subjective and objective cognitive function evaluations in older patients with HF are poorly concordant. more...
- Published
- 2018
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31. Method for creating laminarialean kelp colonies using seawater that contains naturally derived polymers
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Yoshinori Katsuyama, Tadashi Kawai, Yuji Hashimoto, Norishige Yotsukura, and Kenitsu Unjo
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0106 biological sciences ,010504 meteorology & atmospheric sciences ,Ecology ,biology ,010604 marine biology & hydrobiology ,Fishing ,Kelp ,Aquatic Science ,biology.organism_classification ,01 natural sciences ,Thallus ,Algae ,Saccharina ,Environmental science ,Biological dispersal ,Animal Science and Zoology ,Marine ecosystem ,Seawater ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences - Abstract
Laminarialean kelps support marine ecosystems by forming marine forests as well as being used as fishery products. As the issue of decay of the marine forest increases in severity, the regeneration of kelp colonies has become a big challenge. Among various techniques used for creating kelp colonies, those that involve the dispersal of zoospores in the sea have potential for widespread use, as they do not require a lot of time, effort, and cost. When water-soluble cellulose was used as a support medium for effectively retaining Saccharina zoospores on the sea bottom, high zoospore sedimentation rates were obtained when the seawater containing the zoospores had a cellulose concentration of 0.5% or lower, and more thalli were confirmed in the sea area where the 0.5% concentration was used compared with sea areas where the 0% and 0.25% concentrations were used. When the zoospores of S. japonica var. ochotensis were dispersed (cellulose concentration: 0.5%; number of mother algae: 50 individuals; and dispersal area: ca. 890 m2) at the kelp fishing ground on the Okhotsk Sea coast of Hokkaido, eight months after the dispersal, 421 first-year thalli per 0.56 m2 were confirmed in the dispersal area compared to 47 in the non-dispersal area (both averages of two quadrats), demonstrating the effectiveness of this technique in improving a kelp fishing ground. more...
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- 2021
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32. Implications of right ventricular septal pacing for medium-term prognosis: Propensity-matched analysis
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Yuji Hashimoto, Shinya Kowase, Yuya Matsue, Kenji Kurosaki, Akihiko Matsumura, Kazutaka Aonuma, Akira Mizukami, Yoshihisa Naruse, Akihiko Nogami, and Makoto Suzuki
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Male ,Pacemaker, Artificial ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Interquartile range ,Internal medicine ,Heart Septum ,medicine ,Clinical endpoint ,Humans ,030212 general & internal medicine ,Propensity Score ,Aged ,Retrospective Studies ,Aged, 80 and over ,Heart Failure ,Ejection fraction ,business.industry ,Hazard ratio ,Cardiac Pacing, Artificial ,Stroke Volume ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Outcome and Process Assessment, Health Care ,Heart failure ,Cohort ,Propensity score matching ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The effect of right ventricular (RV) septal pacing as opposed to RV apical pacing on prognosis in patients undergoing pacemaker implantation remains controversial. This study was performed to examine the clinical efficacy of RV septal pacing in a large cohort with medium-term follow-up and propensity-matched analysis. Methods A total of 982 consecutive patients with first pacemaker implantation between 2008 and 2013 at two centers in Japan (51.4% male, age 76.1±10.6years, 64.3% septal pacing, 94% preserved ejection fraction [EF]) were enrolled. Propensity matching successfully matched 446 patients into RV septal and apical pacing groups. The primary endpoint, a combination of all-cause death and hospitalization due to heart failure, was compared between the two groups. Results In the propensity-matched cohort, the primary endpoint was observed in 61 patients (13.7%) over a median follow-up period of 2.1years (interquartile range, 1.1–3.5years). The effects of septal pacing on prognosis were not statistically significant (hazard ratio [HR]=1.10, 95% confidence interval [CI]=0.60–2.04, P=0.752). No significant benefit of septal pacing was observed on all-cause death (HR=1.86, 95%CI=0.74–4.66, P=0.187) and heart failure hospitalization (HR=0.93, 95%CI=0.44–1.98, P=0.847) when assessed separately. Conclusion Septal pacing did not show medium-term advantages in prognosis in this large-scale retrospective cohort study with propensity matching of patients with predominantly preserved EF. more...
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- 2016
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33. Kaplan–Meier survival analysis and Cox regression analyses regarding right ventricular septal pacing: Data from Japanese pacemaker cohort
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Kenji Kurosaki, Akihiko Nogami, Makoto Suzuki, Akira Mizukami, Shinya Kowase, Yuji Hashimoto, Kazutaka Aonuma, Akihiko Matsumura, Yoshihisa Naruse, and Yuya Matsue
- Subjects
medicine.medical_specialty ,Heart failure ,030204 cardiovascular system & hematology ,lcsh:Computer applications to medicine. Medical informatics ,Pacemaker implantation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,Research article ,Mortality ,lcsh:Science (General) ,Survival analysis ,Data Article ,Data ,Multidisciplinary ,RV septal pacing ,business.industry ,Proportional hazards model ,medicine.disease ,Prognosis ,Surgery ,030220 oncology & carcinogenesis ,Cohort ,Cardiology ,lcsh:R858-859.7 ,business ,RV non-apical pacing ,lcsh:Q1-390 - Abstract
The presented data were obtained from 982 consecutive patients receiving their first pacemaker implantation with right ventricular (RV) lead placement between January 2008 and December 2013 at two centers in Japan. Patients were divided into RV apical and septal pacing groups. Data of Kaplan–Meier survival analysis and Cox regression analysis are presented. Refer to the research article “Implications of right ventricular septal pacing for medium-term prognosis: propensity-matched analysis” (Mizukami et al., in press) [1] for further interpretation and discussion. Keywords: RV septal pacing, RV non-apical pacing, Prognosis, Heart failure, Mortality, Data more...
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- 2016
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34. Recovery from hyponatremia in acute phase is associated with better in-hospital mortality rate in acute heart failure syndrome
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Nobuyuki Kagiyama, Teruyoshi Kume, Hiroyuki Okura, Kazuki Yoshida, Kiyoshi Yoshida, Makoto Suzuki, Yuji Hashimoto, Kenji Yoshioka, Yuya Matsue, and Akihiko Matsumura
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Male ,medicine.medical_specialty ,Myocardial Ischemia ,Tolvaptan ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Internal medicine ,Bayesian multivariate linear regression ,medicine ,Humans ,Hospital Mortality ,030212 general & internal medicine ,Male gender ,Aged ,Retrospective Studies ,Heart Failure ,In hospital mortality ,business.industry ,Mortality rate ,Age Factors ,nutritional and metabolic diseases ,Retrospective cohort study ,Benzazepines ,Prognosis ,medicine.disease ,Surgery ,Heart failure ,Acute Disease ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Hyponatremia ,Antidiuretic Hormone Receptor Antagonists ,medicine.drug - Abstract
Although hyponatremia on admission is a predictor of poor prognosis in acute heart failure (AHF) patients, little is known about the association between changes in sodium level in acute phase and in-hospital mortality. This study was performed to clarify the impact of sodium level improvement in the early phase on prognosis in AHF patients.A total of 882 consecutive hospitalized AHF patients were retrospectively enrolled in this study. Sodium levels were evaluated on days 1 and 3 of admission, and patients were classified into three groups: patients with hyponatremia on admission and day 3 (hypo-hypo group); patients with hyponatremia on admission and normonatremia on day 3 (hypo-normo group); and patients with normonatremia on admission (normo group).Hyponatremia (sodium ≤135 mEq/L) was observed in 14.3% of cases. In multivariate linear regression analysis, age (standardized beta=0.084), male gender (standardized beta=-0.072), history of ischemic heart disease (standardized beta=-0.069), baseline sodium level (standardized beta=-0.435), and tolvaptan use (standardized beta=0.093) were independent determinants of changes in sodium level from day 1 to day 3. In-hospital mortality rates were significantly higher in the hypo-hypo group (23.7%) and hypo-normo group (9.7%) than the normo group (6.9%) (p0.001). After adjustment for covariates, both hypo-normo (OR: 0.28, 95% CI: 0.08-0.93, p=0.038) and normo (OR: 0.42, 95% CI: 0.20-0.88, p=0.022) groups showed significantly lower in-hospital mortality rates than the hypo-hypo group.Early recovery from hyponatremia in AHF patients is associated with lower in-hospital mortality rate. more...
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- 2016
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35. Moderate vasomotor response to acetylcholine provocation test as an indicator of long-term prognosis
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Masao Soeda, Maki Ono, Yuta Sudo, Kenji Yoshioka, Masahiro Hoshino, Ryo Ninomiya, Makoto Suzuki, Shunsuke Kuroda, Taishi Yonetsu, Yuji Matsuda, Ryota Iwatsuka, Akira Mizukami, Akihiko Matsumura, and Yuji Hashimoto more...
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Male ,medicine.medical_specialty ,Time Factors ,Provocation test ,Coronary Vasospasm ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Coronary Angiography ,Severity of Illness Index ,Angina Pectoris ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Severity of illness ,medicine ,Humans ,Vasoconstrictor Agents ,030212 general & internal medicine ,Endothelial dysfunction ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Chi-Square Distribution ,Vasomotor ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Coronary Vessels ,Acetylcholine ,Vasomotor System ,Vasoconstriction ,Coronary vasospasm ,Predictive value of tests ,Anesthesia ,Heart Function Tests ,Multivariate Analysis ,Cardiology ,Female ,Isosorbide dinitrate ,Cardiology and Cardiovascular Medicine ,business ,Mace ,medicine.drug - Abstract
The acetylcholine (ACh) provocation test (ACh-test) is used for the diagnosis of vasospastic angina (VSA). However, subjects often show a moderate spasm (MS) response for which diagnosis of VSA is not definitive, and the clinical significance of this response is unknown. We assessed moderate coronary vasomotor response to the ACh test as an indicator of long-term prognosis. A total of 298 consecutive patients who underwent the ACh test for suspected VSA were retrospectively investigated. Coronary spasm severity after intracoronary administration of isosorbide dinitrate was evaluated by measuring epicardial coronary artery diameter reduction after ACh injection. Patients were divided into three groups according to the diameter reduction during the ACh test: severe spasm (SS) showing ≥75 % diameter reduction, MS showing ≥50 % diameter reduction, and others (N). In Kaplan-Meier analysis, the major adverse cardiac event (MACE) rates with a median follow-up of 4.6 years were significantly worse in SS (11.1 %) and MS (8.5 %) than N (1.9 %), (SS vs N; P = 0.009, MS vs N; P = 0.029). Significant difference in MACE rates was not observed between SS and MS (P = 0.534). Cox regression analysis revealed that MS remained an independent predictor of MACE after adjustment for other confounders (HR: 7.18, 95 % CI 1.42-36.4, P = 0.017). Patients with MS by ACh test had a cardiac event rate comparable with that of patients with SS and significantly worse than that of patients with normal vasomotor responses. more...
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- 2016
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36. Plaque morphologies and the clinical prognosis of acute coronary syndrome caused by lesions with intact fibrous cap diagnosed by optical coherence tomography
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Akihiko Matsumura, Yuji Hashimoto, Makoto Suzuki, Taishi Yonetsu, Tsunekazu Kakuta, Tadashi Murai, and Tetsumin Lee
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Male ,Acute coronary syndrome ,medicine.medical_specialty ,medicine.medical_treatment ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Coronary Angiography ,Revascularization ,Culprit ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Intravascular ultrasound ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Acute Coronary Syndrome ,Ultrasonography, Interventional ,Aged ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,Fibrous cap ,Middle Aged ,Prognosis ,medicine.disease ,Coronary Vessels ,Plaque, Atherosclerotic ,medicine.anatomical_structure ,ROC Curve ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Tomography, Optical Coherence - Abstract
Background Pathological studies have suggested that acute coronary syndrome (ACS) may be caused by culprit lesions with intact fibrous cap (IFC), including plaque erosions. This study sought to evaluate the morphological features and clinical outcomes of patients with ACS caused by lesions with IFC. Methods A total of 318 patients with ACS who underwent optical coherence tomography (OCT) of a culprit lesion were investigated. The culprit lesions were categorized as follows: those with plaque rupture (PR group), those with an IFC (IFC group), and those with a massive thrombus precluding plaque visualization (MT group). Intravascular ultrasound (IVUS) was performed in 297 patients. Clinical follow-up data were collected regarding adverse cardiac events, including death, myocardial infarction, revascularization, and congestive heart failure requiring hospitalization. Results Culprit lesions were categorized into 141 RPs, 131 IFCs, and 46 MTs. IFC group exhibited a smaller remodeling index and less frequently attenuated plaques on IVUS. Three hundred and seven patients (96.5%) were followed for a median follow-up duration of 576 days. Adverse cardiac events were observed in 93 patients (30.3%). Kaplan–Meier analysis demonstrated a significantly lower event rate in IFC group compared with the RP and MT groups. Cox proportional hazard analysis demonstrated that an IFC and multivessel disease were independent predictors of adverse events [hazard ratio 0.57, 95% confidence interval (CI) 0.33–0.98, p = 0.043 and hazard ratio 1.72, 95% CI 1.09-2.73, p = 0.021]. Conclusions Culprit lesions with IFC showed smaller remodeling indices by IVUS, and were associated with better long-term prognosis compared with those with plaque rupture. more...
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- 2016
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37. Efficacy of Endovascular Treatment for Occlusive Lesions of a Single M2 Branch in Non-recombinant Tissue Plasminogen Activator Treated Patients
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Masanori Sasaki, Masahito Nakazaki, Masahiko Daibou, Toshiyuki Onda, Yasuyuki Yonemasu, Yuji Hashimoto, Osamu Honda, Akira Takahashi, Tatsufumi Nomura, and Tadashi Nonaka
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medicine.medical_specialty ,business.industry ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Neurology (clinical) ,Radiology ,Recombinant tissue plasminogen activator ,Endovascular treatment ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Published
- 2016
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38. A case of carcinoid heart disease with rapid progression of symptoms
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Kenji Yoshioka, Nobuyuki Kagiyama, Yuji Hashimoto, Yoshihito Otsuka, Hiroaki Tanabe, Akira Mizukami, Koichi Honma, and Izumi Sumatani
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03 medical and health sciences ,medicine.medical_specialty ,Pathology ,0302 clinical medicine ,business.industry ,Internal medicine ,Carcinoid Heart Disease ,Medicine ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,030204 cardiovascular system & hematology ,business ,Gastroenterology - Published
- 2016
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39. Correlation of functional fitness with arterial stiffness in community middle-aged and older women
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Ayako Azuma, Yasuaki Tamura, Hajime Miura, Yuji Hashimoto, and Miduki Ishikawa
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Gerontology ,Correlation ,Thesaurus (information retrieval) ,Functional training ,Arterial stiffness ,medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Psychology ,medicine.disease - Published
- 2016
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40. Long-term follow-up of rivaroxaban use in Japanese patients with non-valvular atrial fibrillation
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Yuji Hashimoto, Akihiko Matsumura, Akira Mizukami, Shunsuke Kuroda, Maki Ohno, Makoto Suzuki, and Ryota Iwatsuka
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Intracerebral hemorrhage ,medicine.medical_specialty ,Rivaroxaban ,business.industry ,Long term follow up ,Endocrinology, Diabetes and Metabolism ,Non valvular atrial fibrillation ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Ischemic stroke ,Cardiology ,Medicine ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Published
- 2017
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41. Tandem internal models execute motor learning in the cerebellum
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Masao Ito, Kinya Ishikawa, Hidehiro Mizusawa, Takanori Yokota, Soichi Nagao, Yuji Hashimoto, and Takeru Honda
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Adult ,Male ,cerebellar degeneration ,Cerebellum ,forward model ,Computer science ,education ,Models, Neurological ,Motor Activity ,050105 experimental psychology ,03 medical and health sciences ,Computational architecture ,0302 clinical medicine ,medicine ,motor control ,Humans ,Learning ,0501 psychology and cognitive sciences ,Aged ,prism adaptation ,Aged, 80 and over ,Multidisciplinary ,Tandem ,05 social sciences ,Subliminal stimuli ,Motor control ,Cognition ,inverse model ,Middle Aged ,Biological Sciences ,Hand ,medicine.anatomical_structure ,Female ,Motor learning ,Neuroscience ,Prism adaptation ,030217 neurology & neurosurgery - Abstract
Significance The formation and dissolution of internal models of the human body occur in the cerebellum, and their logical organization is essential for normal motor learning. Here, we propose that the two known types of internal models, forward and inverse, are combined into one tandem model. We analyzed human motor learning, theoretically and experimentally, in a prism-adaptation hand-reaching task. Remarkably, the behavioral analyses and computational modeling converged to support the existence of a tandem model and reveal its unique features in cerebellum-based motor learning. For example, intentional misreaching induced covert learning in the tandem model. Finally, the tandem model was used to index the nature and degree of cerebellar damage in patients., In performing skillful movement, humans use predictions from internal models formed by repetition learning. However, the computational organization of internal models in the brain remains unknown. Here, we demonstrate that a computational architecture employing a tandem configuration of forward and inverse internal models enables efficient motor learning in the cerebellum. The model predicted learning adaptations observed in hand-reaching experiments in humans wearing a prism lens and explained the kinetic components of these behavioral adaptations. The tandem system also predicted a form of subliminal motor learning that was experimentally validated after training intentional misses of hand targets. Patients with cerebellar degeneration disease showed behavioral impairments consistent with tandemly arranged internal models. These findings validate computational tandemization of internal models in motor control and its potential uses in more complex forms of learning and cognition. more...
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- 2018
42. Cardiovascular Outcomes in Patients with Previous Myocardial Infarction and Mild Diabetes Mellitus Following Treatment with Pioglitazone -Reports from the Japan Working Group for the Assessment Whether Pioglitazone Protects Dm Patients Against Re-Infarction (Ppar Study)
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Kenshi Fujii, Koichi Mizuno, Tohru Kohno, Reimin Sawada, Nobuyuki Ohte, Masatake Fukunami, Kazuo Satake, Masaaki Uematsu, Koichi Tamita, Toshimitsu Hamasaki, Makoto Shimizu, Masafumi Kitakaze, Yorihiko Higashino, Hideo Himeno, Toyoaki Murohara, Hiroshi Suzuki, Takaaki Shiono, Hiroshi Asanuma, Yuji Hashimoto, Shunichi Yoda, Shuntaro Ikeda, Kengo Tsukahara, Makoto Nakahama, Yasuharu Nakama, Yoshiyuki Nagai, Kazuki Fukui, Hiroyuki Takase, Shinji Koba, Masanori Asakura, Jun Takahashi, Yoshihiko Kinoshita, Susumu Fujino, Hiroyasu Uzui, Shoji Yano, Jiyoong Kim, Tsutomu Endo, Hounin Kanaya, Taku Matsubara, Takanori Ookusa, Hideki Hayashi, Mitsuru Tsujimoto, Yasuyuki Maruyama, Motoshi Takeuchi, Tetsuya Ishikawa, Shinji Okubo, Kousei Ueda, and Sumio Mizuno more...
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medicine.medical_specialty ,business.industry ,Unstable angina ,medicine.medical_treatment ,Percutaneous coronary intervention ,medicine.disease ,Internal medicine ,Diabetes mellitus ,medicine ,Clinical endpoint ,Myocardial infarction ,business ,Pioglitazone ,Stroke ,medicine.drug ,Macrovascular disease - Abstract
Background: Secondary prevention in patients with myocardial infarction (MI) is critically important to prevent ischaemic heart failure and reduce social burden. Pioglitazone improves vascular dysfunction and prevents coronary atherosclerosis, mainly via anti-inflammatory and antiatherogenic effects by enhancing adiponectin production in addition to antihyperglycemic effects, thus suggesting that pioglitazone attenuates cardiovascular events in patients with mild (HbA1c levels < 6·5%) diabetes mellitus (DM). Therefore, we evaluated the effects of pioglitazone on cardiovascular events in patients with both previous MI and mild DM. Methods: In this multicentre, prospective, randomised, open, blinded-endpoint trial of PPAR study, we randomly assigned 630 patients with mild DM with a history of MI to undergo either DM therapy with (pioglitazone group) or without (control group) pioglitazone. DM was diagnosed using the 75-g oral glucose tolerance test, and mild DM was defined if HbA1c level was < 6·5%. The primary endpoint was the composite of cardiovascular death and hospitalisation caused by acute MI, unstable angina, coronary revascularisation (including percutaneous coronary intervention and cardiac bypass surgery), and stroke. HbA1C levels were 5·9 and 5·8% (p = 0.71) at baseline and 6·0 and 5·8% (p < 0.01) at 2 years for the control and pioglitazone groups, respectively. Findings: The primary endpoint was observed in 14·2% and 14·1% patients in the control and pioglitazone groups during two years, respectively; the incidence of MI and stroke was 0·3% and 2·2% and 1·0% and 0·3%, respectively. Post-hoc analyses of the 7-year observation period showed that these trends became clearer. Interpretation: Pioglitazone could not reduce the occurrence of cardiovascular events in patients with mild DM and previous MI. This result contradicts the results of the IRIS trial that pioglitazone decreased cardiovascular events in stroke patients or the results of the PROactive trial that pioglitazone decreased cardiovascular events in patients with moderate DM and macrovascular disease. Funding: The Grants of Japan Heart Foundation for PPAR study. Conflict of Interest: Dr. Asakura reports grants from Acterion Pharmaceutical Japan, grants from Boehringer Ingelheim Japan, Inc., personal fees from Otsuka Pharmaceutical Co., Ltd., personal fees from Sanofi K.K., personal fees from Bayer Yakuhin, Ltd., personal fees from MSD K.K., personal fees from Takeda Pharmaceutical Company Limited., personal fees from ONO PHARMACEUTICAL CO., LTD., personal fees from Mitsubishi Tanabe Pharma Corporation, personal fees from DAIICHI SANKYO COMPANY, LIMITED , personal fees from Pfizer Japan Inc., personal fees from Astellas Amgen Biopharma, outside the submitted work. Dr. Kim has nothing to disclose. Dr. Asanuma reports grants from Japan Heart Foundation, during the conduct of the study; grants from Japan Society For The Promotion Of Science (Grants-in-Aid For Scientific Research), grants from Novartis Pharmaceuticals Corporation, grants from Mitsubishi Tanabe Pharma Corporation, personal fees from Otsuka Pharmaceutical Co,Ltd, personal fees from Kyowa Hakko Kirin Co, Ltd, personal fees from Daiichi Sankyo Company, Limited, outside the submitted work. Dr. Hamasaki has nothing to disclose. Dr. Nakama has nothing to disclose. Dr. Tsukahara reports grants from Japan Heart Foundation, during the conduct of the study. Dr. Higashino reports grants from Japan Heart Foundation, during the conduct of the study. Dr. Ishikawa reports grants from Japan Heart Foundation during the conduct of the study. Dr. Koba reports grants from Japan Heart Foundation during the conduct of the study; grants from Daiichi Sankyo Company, Ltd, personal fees from MSD K.K. outside the submitted work. Ethical Approval Statement: The study was performed following the principles of the Declaration of Helsinki and the Japanese ethical guidelines for clinical research. more...
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- 2018
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43. Carperitide Is Associated With Increased In-Hospital Mortality in Acute Heart Failure: A Propensity Score–Matched Analysis
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Makoto Suzuki, Yuji Hashimoto, Akihiko Matsumura, Kiyoshi Yoshida, Yuya Matsue, Kazuki Yoshida, Teruyoshi Kume, Nobuyuki Kagiyama, and Hiroyuki Okura
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Male ,medicine.medical_specialty ,Risk Assessment ,Drug Administration Schedule ,Statistics, Nonparametric ,law.invention ,Japan ,Randomized controlled trial ,Reference Values ,law ,Cause of Death ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,Hospital Mortality ,Propensity Score ,Aged ,Retrospective Studies ,Aged, 80 and over ,Heart Failure ,Academic Medical Centers ,Dose-Response Relationship, Drug ,business.industry ,Incidence ,Mortality rate ,Odds ratio ,medicine.disease ,Confidence interval ,Area Under Curve ,Case-Control Studies ,Heart failure ,Acute Disease ,Cohort ,Propensity score matching ,Cardiology ,Female ,Patient Safety ,Cardiology and Cardiovascular Medicine ,business ,Atrial Natriuretic Factor - Abstract
Background Carperitide (α–human A-type natriuretic peptide) has been used for more than one-half of all acute heart failure (AHF) patients in Japan. However, its clinical effectiveness is not well documented. Methods We retrospectively identified AHF patients presenting with acute onset or worsening of symptoms and admitted to 1 of the 3 participating hospitals. Propensity score–matched analysis was performed. The primary end point was in-hospital mortality. Results Of all of the AHF patients included in this study, 402 (38.7%) were treated with carperitide, and in-hospital mortality rate for the total cohort was 7.6%. We matched 367 pairs of patients treated with and without carperitide according to propensity score. In this matched cohort, treatment with carperitide was associated with in-hospital mortality (odds ratio [OR] 2.13, 95% confidence interval [CI] 1.17–3.85; P = .013). Potentially more harmful effects were observed in elderly patients (OR 2.93, 95% CI 1.54–5.91). Conclusions Carperitide was significantly associated with increased in-hospital mortality rate in AHF patients. Our results strongly suggest the necessity for well designed randomized clinical trials of carperitide to determine its clinical safety and effectiveness. more...
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- 2015
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44. Clinical Features and Prognosis of Type 2 Myocardial Infarction in Vasospastic Angina
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Masahiro Hoshino, Makoto Suzuki, Taishi Yonetsu, Kazuki Yoshida, Yuji Hashimoto, Yuya Matsue, Masayuki Yoshida, and Akihiko Matsumura
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Adult ,Male ,medicine.medical_specialty ,Population ,Myocardial Infarction ,Coronary Vasospasm ,Kaplan-Meier Estimate ,Chest pain ,Angina Pectoris ,Japan ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Odds Ratio ,Clinical endpoint ,Humans ,Medicine ,cardiovascular diseases ,Myocardial infarction ,education ,Aged ,Proportional Hazards Models ,Retrospective Studies ,education.field_of_study ,biology ,business.industry ,Incidence ,Hazard ratio ,Electrocardiography in myocardial infarction ,Vasospasm ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Troponin ,cardiovascular system ,biology.protein ,Cardiology ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Background Although generally the prognosis of vasospastic angina is considered excellent, vasospasm has been shown to be a cause of type 2 myocardial infarction. This study was performed to investigate the clinical characteristics and prognosis of patients with vasospastic angina complicated with type 2 myocardial infarction. Methods We performed a retrospective analysis of 171 consecutive patients with definite vasospastic angina (median age, 64 years; 55.0% were male) who visited the Kameda Medical Center with chest pain and in whom cardiac troponin I level was measured between 2005 and 2013. The patients were divided into type 2 myocardial infarction and non–type 2 myocardial infarction groups. A diagnosis of type 2 myocardial infarction was based on a serum cardiac troponin I value >99th percentile upper reference limit. The primary end point was a combination of nonfatal myocardial infarction or death by any cause. Results A total of 42 patients (24.6%) were diagnosed with type 2 myocardial infarction, and the type 2 myocardial infarction group had a higher incidence of combined end point than the non-type 2 myocardial infarction group during the median follow-up of 4.4 years (26.2% vs 9.3%, respectively, P = .008). Type 2 myocardial infarction remained an independent predictor of combined end point even after adjusting by the Japanese Coronary Spasm Association risk factors for combined end point (hazard ratio, 2.84; 95% confidence interval, 1.22-6.61; P = .02). Conclusions Approximately one quarter of patients with vasospastic angina were associated with type 2 myocardial infarction, and this population should be identified as a new high-risk subgroup of those with vasospastic angina requiring an alternative treatment strategy. more...
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- 2015
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45. Zn2+-dependent increase in cells with phosphatidylserine-exposed membranes after treatment with submicromolar concentrations of 2-n-octyl-4-isothiazolin-3-one in rat thymocytes
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Yasuo Oyama, Yasuaki Tamura, Shiro Ishida, Eri Fukunaga, Sari Honda, and Yuji Hashimoto
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chemistry.chemical_compound ,Chromatography ,Membrane ,Biochemistry ,Membrane permeability ,Chemistry ,chemistry.chemical_element ,Zinc ,Phosphatidylserine ,2-n-Octyl-4-isothiazolin-3-one ,Cytotoxicity ,Antimicrobial ,After treatment - Published
- 2015
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46. Histological examination of the right atrial appendage after failed catheter ablation for focal atrial tachycardia complicated by cardiogenic shock in a post-partum patient
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Akihiko Matsumura, Akira Mizukami, Makoto Suzuki, Shunsuke Kuroda, Taishi Yonetsu, Yuji Hashimoto, Maki Ono, Ryota Iwatsuka, Yuya Matsue, and Rena Nakamura
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Tachycardia ,Cardiac function curve ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Histology ,Circulatory collapse ,medicine.medical_treatment ,Right atrial appendage ,Atrial tachycardia ,Catheter ablation ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Internal medicine ,medicine ,030212 general & internal medicine ,Cardiogenic shock ,Rapid Firing ,business.industry ,Ablation ,medicine.disease ,Surgery ,lcsh:RC666-701 ,cardiovascular system ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Cardioversions ,business - Abstract
A 26-year-old woman in her first pregnancy presented with persistent atrial tachycardia (AT). AT was resistant to medications, cardioversions, and the first attempt of catheter ablation. Two months after delivery she developed severe systolic dysfunction and circulatory collapse. Emergent catheter ablation was performed with the support of percutaneous cardiopulmonary bypass and intraaortic balloon pump. The AT originated in the apex of the right atrial appendage (RAA). Repeated attempts at ablation were unsuccessful, prompting surgical RAA resection, which terminated the tachycardia and improved the cardiac function. Histological examination of resected RAA provided insights into mechanism of resistance to catheter ablation. more...
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- 2016
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47. [Development of Deep Venous Thrombosis Shortly after Neurological Surgery]
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Yuji, Hashimoto, Toshiyuki, Onda, Tatsufumi, Nomura, Yasuyuki, Yonemasu, Osamu, Honda, Masahiko, Toshima, Akira, Takahashi, Tadashi, Nonaka, and Masahiko, Daibo
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Male ,Venous Thrombosis ,Humans ,Female ,Neurosurgical Procedures ,Aged ,Retrospective Studies - Abstract
Little is known about the incidence and characteristics of deep venous thrombosis(DVT)developing shortly after neurological surgery. Lower extremity venous ultrasound scanning was performed before and after surgery, and retrospective data of 157 surgical cases, including endovascular surgery(42.0%), craniotomy(28.7%), burr hole(24.2%), and shunt(3.2%), were evaluated. DVT that had not been pre-operatively observed was discovered in five cases of surgery(five patients, 3.2%)on the day following the surgery, and it was asymptomatic in all cases. One patient was diagnosed with pulmonary thromboembolism as a complication. No difference in characteristic factors was observed between the presence and absence of DVT development. In addition, DVT was detected on preoperative examinations in 10 cases of surgery(10 patients, 6.4%). On the basis of these results, ambulation on the first postoperative day is considered mostly safe. On the other hand, taking into account the increase in the number of patients with DVT and the possibility that a thrombus present in calf veins propagates toward the proximal side, pre-and post-operative screening tests should be performed more often. more...
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- 2017
48. Arterial inflammation measured by
- Author
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Ryota, Iwatsuka, Yuya, Matsue, Taishi, Yonetsu, Toshihiro, O'uchi, Akihiko, Matsumura, Yuji, Hashimoto, and Kenzo, Hirao
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Aged, 80 and over ,Male ,Aging ,Time Factors ,Aortitis ,Age Factors ,Coronary Artery Disease ,Prognosis ,Risk Assessment ,Fluorodeoxyglucose F18 ,Predictive Value of Tests ,Risk Factors ,Positron Emission Tomography Computed Tomography ,Humans ,Female ,Radiopharmaceuticals ,Aged ,Retrospective Studies - Abstract
AlthoughWe retrospectively utilized the records of 309 subjects aged over 65 years, without a history of coronary artery disease, who underwentDuring a median follow-up of 3.9 years, 28 subjects experienced CHD events and 12 patients died due to non-CHD causes. The highest TBR tertile was associated with a high CHD event rate, accounting for death due to non-CHD causes as a competing risk (Gray test, p = 0.005). In a Fine and Gray competing risk proportional hazard regression model, TBR was associated with significantly high CHD events independently of FRS, with a hazard ratio (HR) of 1.19 per 0.1 TBR increase (p 0.001). Likewise, a significant increase in the area under the curve (from 0.57 to 0.73, p = 0.028) and a significant improvement in net reclassification (0.42, p = 0.038) were observed when TBR was added to the model with FRS alone.In older subjects with no history of malignant disease or overt coronary artery disease, arterial inflammation evaluated by FDG uptake provides information on future occurrence of coronary artery events. more...
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- 2017
49. Secure Grouping Protocol Using a Deck of Cards
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Masaki Inamura, Yuji Hashimoto, Koji Nuida, Goichiro Hanaoka, and Kazumasa Shinagawa
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FOS: Computer and information sciences ,Theoretical computer science ,Computer Science - Cryptography and Security ,Computer science ,Real-time computing ,0211 other engineering and technologies ,02 engineering and technology ,Permutation ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Protocol (object-oriented programming) ,021110 strategic, defence & security studies ,SIMPLE (military communications protocol) ,Applied Mathematics ,computer.file_format ,Construct (python library) ,Trusted third party ,Computer Graphics and Computer-Aided Design ,Standard 52-card deck ,Signal Processing ,Key (cryptography) ,020201 artificial intelligence & image processing ,Executable ,Cryptography and Security (cs.CR) ,computer ,94A60 - Abstract
We consider a problem, which we call secure grouping, of dividing a number of parties into some subsets (groups) in the following manner: Each party has to know the other members of his/her group, while he/she may not know anything about how the remaining parties are divided (except for certain public predetermined constraints, such as the number of parties in each group). In this paper, we construct an information-theoretically secure protocol using a deck of physical cards to solve the problem, which is jointly executable by the parties themselves without a trusted third party. Despite the non-triviality and the potential usefulness of the secure grouping, our proposed protocol is fairly simple to describe and execute. Our protocol is based on algebraic properties of conjugate permutations. A key ingredient of our protocol is our new techniques to apply multiplication and inverse operations to hidden permutations (i.e., those encoded by using face-down cards), which would be of independent interest and would have various potential applications. more...
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- 2017
50. Does Treatment of Impaired Glucose Tolerance Improve Cardiovascular Outcomes in Patients with Previous Myocardial Infarction?
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Yoshiyuki Nagai, Yoshihiko Kinoshita, Sumio Mizuno, Shunichi Yoda, Takahisa Yamada, Isao Morii, Masashi Fujita, Yasuyuki Maruyama, Takahiro Muroya, Hiroshi Suzuki, Reimin Sawada, Takayoshi Yamanouchi, Abc investigators, Susumu Fujino, Mitsuru Tsujimoto, Masataka Sata, Kazuki Fukui, Yasuharu Nakama, Takanori Ohkusa, Toyoaki Murohara, Yuji Hashimoto, Hiroyuki Takase, Tetsuya Ishikawa, Hajime Yamaguchi, Nobuyuki Ohte, Masafumi Kitakaze, Hideki Hayashi, Shuntaro Ikeda, Kazuo Satake, Hideo Himeno, Tomohiko Shigemasa, Koichi Tamita, Jiyoong Kim, Hiroyasu Uzui, Yorihiko Higashino, Masanori Asakura, Tsutomu Endo, Tetsuro Ueda, Makoto Nakahama, Tatsuya Nunohiro, Osamu Doi, Toshimitsu Hamasaki, Takaaki Shiono, Kengo Tsukahara, Tohru Kohno, Makoto Shimizu, Satoru Sakagami, Yukiko Morita, Shinji Koba, Yoshikazu Hiasa, Hiroshi Asanuma, and Jitsuo Higaki more...
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Impaired glucose tolerance ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Internal medicine ,Voglibose ,Glucose Intolerance ,Clinical endpoint ,Secondary Prevention ,Medicine ,Humans ,Hypoglycemic Agents ,Pharmacology (medical) ,Glycoside Hydrolase Inhibitors ,030212 general & internal medicine ,Myocardial infarction ,Prospective Studies ,Prospective cohort study ,Aged ,Pharmacology ,business.industry ,Unstable angina ,Percutaneous coronary intervention ,General Medicine ,Middle Aged ,medicine.disease ,Discontinuation ,Treatment Outcome ,Cardiovascular Diseases ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Inositol ,medicine.drug - Abstract
We evaluated the effects of an alpha-glucosidase inhibitor, voglibose, on cardiovascular events in patients with a previous myocardial infarction (MI) and impaired glucose tolerance (IGT). This prospective, randomized, open, blinded-endpoint study was conducted in 112 hospitals and clinics in Japan in 3000 subjects with both previous MI and IGT receiving voglibose (0.6 mg/day, n = 424) or no drugs (n = 435) for 2 years. The Data and Safety Monitoring Board (DSMB) recommended discontinuation of the study in June 2012 after an interim analysis when the outcomes of 859 subjects were obtained. The primary endpoint was cardiovascular events including cardiovascular death, nonfatal MI, nonfatal unstable angina, nonfatal stroke, and percutaneous coronary intervention/coronary artery bypass graft. Secondary endpoints included individual components of the primary endpoint in addition to all-cause mortality and hospitalization due to heart failure. The age, ratio of males, and HbA1C were 65 vs. 65 years, 86 vs. 87%, and 5.6 vs. 5.5% in the groups with and without voglibose, respectively. Voglibose improved IGT; however, Kaplan–Meier analysis showed no significant between-group difference with respect to cardiovascular events [12.5% with voglibose vs. 10.1% without voglibose for the primary endpoint (95% confidence interval, 0.82–1.86)]; there were no significant differences in secondary endpoints. Although voglibose effectively treated IGT, no additional benefits for cardiovascular events in patients with previous MI and IGT were observed. Voglibose may not be a contributing therapy to the secondary prevention in patients with MI and IGT. Clinicaltrials.gov number: NCT00212017 more...
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- 2017
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