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This paper studies finite sample minimax optimal randomization schemes and estimation schemes in estimating parameters including the average treatment effect, when treatment effects are heterogeneous. A randomization scheme is a distribution over a group of permutations of a given treatment assignment vector. An estimation scheme is a joint distribution over assignment vectors, linear estimators, and permutations of assignment vectors. The key element in the minimax problem is that the worst case is over a class of distributions of the data which is invariant to a group of permutations. First, I show that given any assignment vector and any estimator, the uniform distribution over the same group of permutations, namely the complete randomization scheme, is minimax optimal. Second, under further assumptions on the class of distributions and the objective function, I show the minimax optimal estimation scheme involves completely randomizing an assignment vector, while the optimal estimator is the difference-in-means under complete invariance and a weighted average of within-block differences under a block structure, and the number of treated units is determined by the Neyman allocation.

This paper studies the optimality of matched-pair designs in randomized controlled trials (RCTs). Matched-pair designs are examples of stratified randomization, in which the researcher partitions a set of units into strata based on their observed covariates and assign a fraction of units in each stratum to treatment. A matched-pair design is such a procedure with two units per stratum. Despite the prevalence of stratified randomization in RCTs, implementations differ vastly. We provide an econometric framework in which, among all stratified randomization procedures, the optimal one in terms of the mean-squared error of the difference-in-means estimator is a matched-pair design that orders units according to a scalar function of their covariates and matches adjacent units. Our framework captures a leading motivation for stratifying in the sense that it shows that the proposed matched-pair design additionally minimizes the magnitude of the ex-post bias, i.e., the bias of the estimator conditional on realized treatment status. We then consider empirical counterparts to the optimal stratification using data from pilot experiments and provide two different procedures depending on whether the sample size of the pilot is large or small. For each procedure, we develop methods for testing the null hypothesis that the average treatment effect equals a prespecified value. Each test we provide is asymptotically exact in the sense that the limiting rejection probability under the null equals the nominal level. We run an experiment on the Amazon Mechanical Turk using one of the proposed procedures, replicating one of the treatment arms in Dellavigna and Pope (2018), and find the standard error decreases by 29%, so that only half of the sample size is required to attain the same standard error.

We provide large-sample distribution theory for support vector regression (SVR) with l1-norm along with error bars for the SVR regression coefficients. Although a classical Wald confidence interval obtains from our theory, its implementation inherently depends on the choice of a tuning parameter that scales the variance estimate and thus the width of the error bars. We address this shortcoming by further proposing an alternative large-sample inference method based on the inversion of a novel test statistic that displays competitive power properties and does not depend on the choice of a tuning parameter.

This article considers the problem of testing a finite number of moment inequalities. For this problem, Romano, Shaikh, and Wolf proposed a two-step testing procedure. In the first step, the proced...

Cr (VI) exists in anion form and can be reduced to positive charged Cr (III) under certain conditions. Can positive charged Cr (III) be continually used for absorbing Cr (VI) to achieve cyclic accumulation of chromium? In this paper, an ion imprinting material for adsorption of Cr (VI) was prepared by dispersing polypyrrole (PPy) in a gelatin/chitosan (Gel/CS) hydrogel network, named Gel/CS/PPy. Based on the conversion of Cr (VI) to Cr (III), a cyclic enrichment process including adsorption-photoreduction-fixation-readsorption of Cr (VI) was established in Gel/CS/PPy hydrogel. The composition and structure of the Gel/CS/PPy were analyzed by scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FT-IR), thermogravimetric (TGA), texture analyzer (Universal TA), zeta potential and ultraviolet-visible-near infrared spectra (UV-vis-NIR). The conversion of Cr (VI) and Cr (III) and its promoting effect on readsorption were verified by XPS. The results showed that Gel/CS/PPy has good adsorption capacity for Cr (VI) and excellent photocatalytic ability to reduce Cr (VI) to Cr (III). Cr (III)-loaded Gel/CS/PPy can be further used to adsorb Cr (VI) and showed good adsorption efficiency even after four cycles. The optimal operating condition for Cr (VI) adsorption is pH = 3; 2 g/L dose of Gel/CS/PPy; and the adsorption capacity of Cr (VI) was about 106.8 mg/g after six adsorption cycles. Since Gel/CS/PPy is composed of organic components, high purity chromium can be recovered by simple calcination method later. Therefore, the synthesized Gel/CS/PPy has great potential in the practical application of low concentration Cr (VI) treatment in water.

This paper considers the problem of testing a finite number of moment inequalities. For this problem, Romano et al. (2014) propose a two-step testing procedure. In the first step, the procedure incorporates information about the location of moments using a confidence region. In the second step, the procedure accounts for the use of the confidence region in the first step by adjusting the significance level of the test appropriately. An important feature of the proposed method is that it is “practical” in the sense that it remains computationally feasible even if the number of moments is large. Its justification, however, has so far been limited to settings in which the number of moments is fixed with the sample size. In this paper, we provide weak assumptions under which the same procedure remains valid even in settings in which there are “many” moments in the sense that the number of moments grows rapidly with the sample size. We confirm the practical relevance of our theoretical guarantees in a simulation study. We additionally provide both numerical and theoretical evidence that the procedure compares favorably with the method proposed by Chernozhukov et al. (2019), which has also been shown to be valid in such settings.

This paper studies inference for the average treatment effect in randomized controlled trials where treatment status is determined according to a “matched pairs” design. By a “matched pairs” design, we mean that units are sampled i.i.d. from the population of interest, paired according to observed, baseline covariates and finally, within each pair, one unit is selected at random for treatment. This type of design is used routinely throughout the sciences, but results about its implications for inference about the average treatment effect are not available. The main requirement underlying our analysis is that pairs are formed so that units within pairs are suitably “close” in terms of the baseline covariates, and we develop novel results to ensure that pairs are formed in a way that satisfies this condition. Under this assumption, we show that, for the problem of testing the null hypothesis that the average treatment effect equals a pre-specified value in such settings, the commonly used two-sample t-test and “matched pairs” t-test are conservative in the sense that these tests have limiting rejection probability under the null hypothesis no greater than and typically strictly less than the nominal level. We show, however, that a simple adjustment to the standard errors of these tests leads to a test that is asymptotically exact in the sense that its limiting rejection probability under the null hypothesis equals the nominal level. We also study the behavior of randomization tests that arise naturally in these types of settings. When implemented appropriately, we show that this approach also leads to a test that is asymptotically exact in the sense described previously, but additionally has finite-sample rejection probability no greater than the nominal level for certain distributions satisfying the null hypothesis. A simulation study confirms the practical relevance of our theoretical results.

This paper studies finite sample minimax optimal randomization schemes and estimation schemes in estimating parameters including the average treat- ment effect, when treatment effects are heterogeneous. A randomization scheme is a distribution over a group of permutations of a given treatment assignment vector. An estimation scheme is a joint distribution over assignment vectors, linear estimators, and permutations of assignment vectors. The key element in the minimax problem is that the worst case is over a class of distributions of the data which is invariant to a group of permutations. First, I show that given any assignment vector and any estimator, the uniform distribution over the same group of permutations, namely the complete randomization scheme, is minimax optimal. Second, under further assumptions on the class of distributions and the objective function, I show the minimax optimal estimation scheme involves completely randomizing an assignment vector, while the optimal estimator is the difference-in-means under complete invariance and a weighted average of within-block differences under a block structure, and the numbers of treated and untreated units are determined by Neyman allocations.