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The aim and tasks of the study — to evaluate clinical-pathogenetic significance of changes in adsorptive rheological properties of blood serum (ARPB) in patients with different clinical courses of gouty nephropathy. Material and methods. With the help of interfacial tensiorheometry of blood there have been examined 89 patients and 30 apparently healthy people of control group (mainly males). We have used computer devices MPT2-Lauda, ADSA-Toronto and PAT2-Sinterface. Urolithic type of nephropathy has been diagnosed in 39 % of cases, latent one — in 61 %. Reduced kidney function was in 54 % of the examined patients. Results and their discussion. Type of gouty nephropathy has an significant impact on the integral parameters of urine determining the levels of proteinuria, leukocyturia, oxalaturia, uricuria, fibronectinuria, ­b2-microglobulinuria and nitrituria, clearance of creatinine, uric acid, oxypurinol and calcium, and urolithic type of kidney lesion is evident with higher, in comparison with latent type, surface tension of blood serum that is connected with parameters of kidneys function, has prognostic significance, influences the interfacial surface activity and viscoelastic urine properties. Conclusions. ARPB changes reflect the character of gouty nephropathy course, single indices take part in pathogenesis of the disease and might have prognostic significance.

The aim of the study is to evaluate the clinical and pathogenetic value of the changes of adsorptive-rheological properties of blood serum (ARPB) in patients with different clinical forms of gouty arthritis. Eighty nine patients and 30 practically healthy people of the controlled group (mainly males) undergone interfacial tensiometry of blood. There were used computer equipment MPT2-Lauda, ADSA-Toronto and PAT2-Sinterface. intermitting type of arthritis has been observed in 63 % of cases and chronic one in 37 %, mild clinical course of articular syndrome was found in 19 % of cases, moderately severe course was observed in 51 % and severe — in 30 %. There have been determined surface viscosity (SV), elasticity (SE), tension (ST), viscoelastic module (VE), relaxation time (RT), angulation and tensigram phase angle (PhA), angle of real viscoelasticity (ARVE) and integral angle of viscoelasticity (IAVE). Gouty arthritis is accompanied by the significant increase in parameters of blood serum RT on 26 % and IAVE is twice increased whereas SE decreases on 8 %, VE — 26 %, ST — 4 % and ARVE — 11 % that is observed in 45, 39, 36, 48, 44 and 38 % of patients respectively. Gouty arthritis is associated with sexual dimorphism, depends on the form (SE, PhA, IAVE) and the severity of the course (SV, RT, ST) of the articular syndrome, osseous tophi presence (SV, RT, PhA, IAVE) and sonographic signs of articulations lesion. ARPB changes reflect the character of gouty arthritis course, some indices take part in pathogenetic construction of the disease and might have prognostic significance.