Адсорбционно-реологические свойства крови при подагрическом артрите

The aim of the study is to evaluate the clinical and pathogenetic value of the changes of adsorptive-rheological properties of blood serum (ARPB) in patients with different clinical forms of gouty arthritis.Eighty nine patients and 30 practically healthy people of the controlled group (mainly males) undergone interfacial tensiometry of blood. There were used computer equipment MPT2-Lauda, ADSA-Toronto and PAT2-Sinterface. intermitting type of arthritis has been observed in 63 % of cases and chronic one in 37 %, mild clinical course of articular syndrome was found in 19 % of cases, moderately severe course was observed in 51 % and severe — in 30 %. There have been determined surface viscosity (SV), elasticity (SE), tension (ST), viscoelastic module (VE), relaxation time (RT), angulation and tensigram phase angle (PhA), angle of real viscoelasticity (ARVE) and integral angle of viscoelasticity (IAVE). Gouty arthritis is accompanied by the significant increase in parameters of blood serum RT on 26 % and IAVE is twice increased whereas SE decreases on 8 %, VE — 26 %, ST — 4 % and ARVE — 11 % that is observed in 45, 39, 36, 48, 44 and 38 % of patients respectively. Gouty arthritis is associated with sexual dimorphism, depends on the form (SE, PhA, IAVE) and the severity of the course (SV, RT, ST) of the articular syndrome, osseous tophi presence (SV, RT, PhA, IAVE) and sonographic signs of articulations lesion. ARPB changes reflect the character of gouty arthritis course, some indices take part in pathogenetic construction of the disease and might have prognostic significance.