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1. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases

Author

Allen, Mariet, Wang, Xue, Burgess, Jeremy D, Watzlawik, Jens, Serie, Daniel J, Younkin, Curtis S, Nguyen, Thuy, Malphrus, Kimberly G, Lincoln, Sarah, Carrasquillo, Minerva M, Ho, Charlotte, Chakrabarty, Paramita, Strickland, Samantha, Murray, Melissa E, Swarup, Vivek, Geschwind, Daniel H, Seyfried, Nicholas T, Dammer, Eric B, Lah, James J, Levey, Allan I, Golde, Todd E, Funk, Cory, Li, Hongdong, Price, Nathan D, Petersen, Ronald C, Graff‐Radford, Neill R, Younkin, Steven G, Dickson, Dennis W, Crook, Julia R, Asmann, Yan W, and Ertekin‐Taner, Nilüfer

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Aging, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Neurodegenerative, Alzheimer's Disease, 2.1 Biological and endogenous factors, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Alzheimer Disease, Brain, Cohort Studies, Computational Biology, Female, Gene Expression Regulation, Genetic Predisposition to Disease, Humans, Male, Myelin Sheath, Neurons, Supranuclear Palsy, Progressive, Transcriptome, Proteinopathies, Alzheimer's disease, Progressive supranuclear palsy, Myelination, Coexpression networks, Temporal cortex, Cerebellum, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionComparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease pathways.MethodsWe analyzed 940 brain transcriptomes including patients with AD, progressive supranuclear palsy (PSP; a primary tauopathy), and control subjects.ResultsWe identified transcriptional coexpression networks implicated in myelination, which were lower in PSP temporal cortex (TCX) compared with AD. Some of these associations were retained even after adjustments for brain cell population changes. These TCX myelination network structures were preserved in cerebellum but they were not differentially expressed in cerebellum between AD and PSP. Myelination networks were downregulated in both AD and PSP, when compared with control TCX samples.DiscussionDownregulation of myelination networks may underlie both PSP and AD pathophysiology, but may be more pronounced in PSP. These data also highlight conservation of transcriptional networks across brain regions and the influence of cell type changes on these networks.

Published
2018

2. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.

Author

Kouri, Naomi, Ross, Owen A, Dombroski, Beth, Younkin, Curtis S, Serie, Daniel J, Soto-Ortolaza, Alexandra, Baker, Matthew, Finch, Ni Cole A, Yoon, Hyejin, Kim, Jungsu, Fujioka, Shinsuke, McLean, Catriona A, Ghetti, Bernardino, Spina, Salvatore, Cantwell, Laura B, Farlow, Martin R, Grafman, Jordan, Huey, Edward D, Ryung Han, Mi, Beecher, Sherry, Geller, Evan T, Kretzschmar, Hans A, Roeber, Sigrun, Gearing, Marla, Juncos, Jorge L, Vonsattel, Jean Paul G, Van Deerlin, Vivianna M, Grossman, Murray, Hurtig, Howard I, Gross, Rachel G, Arnold, Steven E, Trojanowski, John Q, Lee, Virginia M, Wenning, Gregor K, White, Charles L, Höglinger, Günter U, Müller, Ulrich, Devlin, Bernie, Golbe, Lawrence I, Crook, Julia, Parisi, Joseph E, Boeve, Bradley F, Josephs, Keith A, Wszolek, Zbigniew K, Uitti, Ryan J, Graff-Radford, Neill R, Litvan, Irene, Younkin, Steven G, Wang, Li-San, Ertekin-Taner, Nilüfer, Rademakers, Rosa, Hakonarsen, Hakon, Schellenberg, Gerard D, and Dickson, Dennis W

Subjects
Cerebral Cortex, Humans, Basal Ganglia Diseases, Supranuclear Palsy, Progressive, Neurodegenerative Diseases, Kinesin, SOS1 Protein, tau Proteins, Myelin Proteins, Case-Control Studies, Polymorphism, Single Nucleotide, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study, Young Adult, RNA, Long Noncoding, and over, Polymorphism, Single Nucleotide, RNA, Long Noncoding, Supranuclear Palsy, Progressive
Abstract

Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n=152) and 3,311 controls, and 67 CBD cases and 439 controls in a replication stage. Associations with meta-analysis were 17q21 at MAPT (P=1.42 × 10(-12)), 8p12 at lnc-KIF13B-1, a long non-coding RNA (rs643472; P=3.41 × 10(-8)), and 2p22 at SOS1 (rs963731; P=1.76 × 10(-7)). Testing for association of CBD with top progressive supranuclear palsy (PSP) GWAS single-nucleotide polymorphisms (SNPs) identified associations at MOBP (3p22; rs1768208; P=2.07 × 10(-7)) and MAPT H1c (17q21; rs242557; P=7.91 × 10(-6)). We previously reported SNP/transcript level associations with rs8070723/MAPT, rs242557/MAPT, and rs1768208/MOBP and herein identified association with rs963731/SOS1. We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein).

Published
2015

3. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Author

De Jager, Philip L, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Schalkwyk, Leonard C, Yu, Lei, Eaton, Matthew L, Keenan, Brendan T, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Chai, High S, Younkin, Curtis, Younkin, Steven G, Zou, Fanggeng, Szyf, Moshe, Epstein, Charles B, Schneider, Julie A, Bernstein, Bradley E, Meissner, Alex, Ertekin-Taner, Nilufer, Chibnik, Lori B, Kellis, Manolis, Mill, Jonathan, and Bennett, David A

Subjects
Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Alzheimer's Disease, Human Genome, Genetics, Dementia, Neurodegenerative, Acquired Cognitive Impairment, Aging, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Alzheimer Disease, Amyloidosis, Ankyrins, Brain, Carrier Proteins, CpG Islands, DNA Methylation, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, Nuclear Proteins, Protein Interaction Maps, Tumor Suppressor Proteins, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermore, we functionally validated these CpG associations and identified the nearby genes whose RNA expression was altered in AD: ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2. Our analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.

Published
2014

4. Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Author

Allen, Mariet, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis S, Crook, Julia, Pankratz, V Shane, Carrasquillo, Minerva M, Rowley, Christopher N, Nair, Asha A, Middha, Sumit, Maharjan, Sooraj, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly G, Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin, Schultz, Debra, Rakhshan, Fariborz, Kolbert, Christopher P, Jen, Jin, Haines, Jonathan L, Mayeux, Richard, Pericak-Vance, Margaret A, Farrer, Lindsay A, Schellenberg, Gerard D, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer, Alzheimer's Disease Genetics Consortium (ADGC), Apostolova, Liana G, Arnold, Steven E, Baldwin, Clinton T, Barber, Robert, Barmada, Michael M, Beach, Thomas, Beecham, Gary W, Beekly, Duane, Bennett, David A, Bigio, Eileen H, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Burke, James R, Buros, Jacqueline, Buxbaum, Joseph D, Cairns, Nigel J, Cantwell, Laura B, Cao, Chuanhai, Carlson, Chris S, Carney, Regina M, Carroll, Steven L, Chui, Helena C, Clark, David G, Corneveaux, Jason, Cotman, Carl W, Crane, Paul K, Cruchaga, Carlos, Cummings, Jeffrey L, De Jager, Philip L, DeCarli, Charles, DeKosky, Steven T, Demirci, F Yesim, Diaz-Arrastia, Ramon, Dick, Malcolm, Dombroski, Beth A, Duara, Ranjan, Ellis, William D, Evans, Denis, Faber, Kelley M, Fallon, Kenneth B, Farlow, Martin R, Ferris, Steven, Foroud, Tatiana M, Frosch, Matthew, Galasko, Douglas R, Gallins, Paul J, Ganguli, Mary, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R, Gilman, Sid, Giordani, Bruno, Glass, Jonathan D, Goate, Alison M, Green, Robert C, Growdon, John H, Hakonarson, Hakon, Hamilton, Ronald L, Hardy, John, Harrell, Lindy E, Head, Elizabeth, Honig, Lawrence S, and Huentelman, Matthew J

Subjects
Alzheimer's Disease Genetics Consortium, Temporal Lobe, Humans, Alzheimer Disease, Genetic Predisposition to Disease, RNA, Autopsy, Linear Models, Risk Factors, Gene Expression, Brain Chemistry, Genotype, Gene Dosage, Polymorphism, Single Nucleotide, Alleles, Aged, Female, Male, Apolipoprotein E4, Clinical Research, Alzheimer's Disease, Aging, Acquired Cognitive Impairment, Human Genome, Neurosciences, Dementia, Neurodegenerative, Genetics, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aetiology, 2.1 Biological and endogenous factors, Neurological, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveRecent genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) identified 9 novel risk loci. Discovery of functional variants within genes at these loci is required to confirm their role in Alzheimer disease (AD). Single nucleotide polymorphisms that influence gene expression (eSNPs) constitute an important class of functional variants. We therefore investigated the influence of the novel LOAD risk loci on human brain gene expression.MethodsWe measured gene expression levels in the cerebellum and temporal cortex of autopsied AD subjects and those with other brain pathologies (∼400 total subjects). To determine whether any of the novel LOAD risk variants are eSNPs, we tested their cis-association with expression of 6 nearby LOAD candidate genes detectable in human brain (ABCA7, BIN1, CLU, MS4A4A, MS4A6A, PICALM) and an additional 13 genes ±100 kb of these SNPs. To identify additional eSNPs that influence brain gene expression levels of the novel candidate LOAD genes, we identified SNPs ±100 kb of their location and tested for cis-associations.ResultsCLU rs11136000 (p = 7.81 × 10(-4)) and MS4A4A rs2304933/rs2304935 (p = 1.48 × 10(-4)-1.86 × 10(-4)) significantly influence temporal cortex expression levels of these genes. The LOAD-protective CLU and risky MS4A4A locus alleles associate with higher brain levels of these genes. There are other cis-variants that significantly influence brain expression of CLU and ABCA7 (p = 4.01 × 10(-5)-9.09 × 10(-9)), some of which also associate with AD risk (p = 2.64 × 10(-2)-6.25 × 10(-5)).ConclusionsCLU and MS4A4A eSNPs may at least partly explain the LOAD risk association at these loci. CLU and ABCA7 may harbor additional strong eSNPs. These results have implications in the search for functional variants at the novel LOAD risk loci.

Published
2012

5. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Author

Carrasquillo, Minerva M., Allen, Mariet, Burgess, Jeremy D., Wang, Xue, Strickland, Samantha L., Aryal, Shivani, Siuda, Joanna, Kachadoorian, Michaela L., Medway, Christopher, Younkin, Curtis S., Nair, Asha, Wang, Chen, Chanana, Pritha, Serie, Daniel, Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly G., Morgan, Kevin, Golde, Todd E., Price, Nathan D., White, Charles C., De Jager, Philip L., Bennett, David A., Asmann, Yan W., Crook, Julia E., Petersen, Ronald C., Graff-Radford, Neill R., Dickson, Dennis W., Younkin, Steven G., and Ertekin-Taner, Nilüfer

Published
2017
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6. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

Author

Allen, Mariet, Wang, Xue, Serie, Daniel J., Strickland, Samantha L., Burgess, Jeremy D., Koga, Shunsuke, Younkin, Curtis S., Nguyen, Thuy T., Malphrus, Kimberly G., Lincoln, Sarah J., Alamprese, Melissa, Zhu, Kuixi, Chang, Rui, Carrasquillo, Minerva M., Kouri, Naomi, Murray, Melissa E., Reddy, Joseph S., Funk, Cory, Price, Nathan D., Golde, Todd E., Younkin, Steven G., Asmann, Yan W., Crook, Julia E., Dickson, Dennis W., and Ertekin-Taner, Nilüfer

Published
2018
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7. ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

Author

Conway, Olivia J, Carrasquillo, Minerva M, Wang, Xue, Bredenberg, Jenny M, Reddy, Joseph S, Strickland, Samantha L, Younkin, Curtis S, Burgess, Jeremy D, Allen, Mariet, Lincoln, Sarah J, Nguyen, Thuy, Malphrus, Kimberly G, Soto, Alexandra I, Walton, Ronald L, Boeve, Bradley F, Petersen, Ronald C, Lucas, John A, Ferman, Tanis J, Cheshire, William P, van Gerpen, Jay A, Uitti, Ryan J, Wszolek, Zbigniew K, Ross, Owen A, Dickson, Dennis W, Graff-Radford, Neill R, and Ertekin-Taner, Nilüfer

Published
2018
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8. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci

Author

Allen, Mariet, Burgess, Jeremy D., Ballard, Travis, Serie, Daniel, Wang, Xue, Younkin, Curtis S., Sun, Zhifu, Kouri, Naomi, Baheti, Saurabh, Wang, Chen, Carrasquillo, Minerva M., Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly, Murray, Melissa, Golde, Todd E., Price, Nathan D., Younkin, Steven G., Schellenberg, Gerard D., Asmann, Yan, Ordog, Tamas, Crook, Julia, Dickson, Dennis, and Ertekin-Taner, Nilüfer

Published
2016
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9. Identification of novel Alzheimer’s disease genes co-expressed with TREM2

Author

Reddy, Joseph S., primary, Allen, Mariet, additional, Wang, Xue, additional, Biernacka, Joanna M., additional, Coombes, Brandon J., additional, Jenkins, Gregory D., additional, Sinnwell, Jason P., additional, Carrasquillo, Minerva M., additional, Pottier, Cyril P., additional, Ren, Yingxue, additional, Sarangi, Vivekananda, additional, Younkin, Curtis S., additional, Asmann, Yan W., additional, Ross, Owen A., additional, Rademakers, Rosa, additional, Golde, Todd E., additional, Ertekin-Taner, Nilüfer, additional, and Younkin, Steven G., additional

Published
2020
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10. Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

Author

Allen Mariet, Zou Fanggeng, Chai High, Younkin Curtis S, Miles Richard, Nair Asha A, Crook Julia E, Pankratz V, Carrasquillo Minerva M, Rowley Christopher N, Nguyen Thuy, Ma Li, Malphrus Kimberly G, Bisceglio Gina, Ortolaza Alexandra I, Palusak Ryan, Middha Sumit, Maharjan Sooraj, Georgescu Constantin, Schultz Debra, Rakhshan Fariborz, Kolbert Christopher P, Jen Jin, Sando Sigrid B, Aasly Jan O, Barcikowska Maria, Uitti Ryan J, Wszolek Zbigniew K, Ross Owen A, Petersen Ronald C, Graff-Radford Neill R, Dickson Dennis W, Younkin Steven G, and Ertekin-Taner Nilüfer

Subjects
GSTO genes, Disease risk, Gene expression, Association, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Abstract

Abstract Background Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may underlie the pathophysiology of both diseases. GSTO polymorphisms were previously reported to associate with risk and age-at-onset of these diseases, although inconsistent follow-up study designs make interpretation of results difficult. We assessed two previously reported SNPs, GSTO1 rs4925 and GSTO2 rs156697, in AD (3,493 ADs vs. 4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects). Results We found that rs156697 minor allele associates with significantly increased risk (odds ratio = 1.14, p = 0.038) in the older ADs with age-at-diagnosis > 80 years. The minor allele of GSTO1 rs4925 associates with decreased risk in familial PD (odds ratio = 0.78, p = 0.034). There was no other association with disease risk or age-at-diagnosis. The minor alleles of both GSTO SNPs associate with lower brain levels of GSTO2 (p = 4.7 × 10-11-1.9 × 10-27), but not GSTO1. Pathway analysis of significant genes in our brain expression GWAS, identified significant enrichment for glutathione metabolism genes (p = 0.003). Conclusion These results suggest that GSTO locus variants may lower brain GSTO2 levels and consequently confer AD risk in older age. Other glutathione metabolism genes should be assessed for their effects on AD and other chronic, neurologic diseases.

Published
2012
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11. TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease

Author

Chakrabarty, Paramita, primary, Li, Andrew, additional, Ladd, Thomas B., additional, Strickland, Michael R., additional, Koller, Emily J., additional, Burgess, Jeremy D., additional, Funk, Cory C., additional, Cruz, Pedro E., additional, Allen, Mariet, additional, Yaroshenko, Mariya, additional, Wang, Xue, additional, Younkin, Curtis, additional, Reddy, Joseph, additional, Lohrer, Benjamin, additional, Mehrke, Leonie, additional, Moore, Brenda D., additional, Liu, Xuefei, additional, Ceballos-Diaz, Carolina, additional, Rosario, Awilda M., additional, Medway, Christopher, additional, Janus, Christopher, additional, Li, Hong-Dong, additional, Dickson, Dennis W., additional, Giasson, Benoit I., additional, Price, Nathan D., additional, Younkin, Steven G., additional, Ertekin-Taner, Nilüfer, additional, and Golde, Todd E., additional

Published
2018
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12. O3‐06‐02: POLYGENIC SCORE ANALYSIS OF EXONIC VARIANTS IN AN IMMUNE CO‐REGULATORY NETWORK IDENTIFIES NOVEL PROTEIN‐ALTERING VARIANTS THAT ASSOCIATE WITH ALZHEIMER'S DISEASE

Author

Reddy, Joseph S., primary, Allen, Mariet, additional, Wang, Xue, additional, Biernacka, Joanna M., additional, Gregory, Jenkins D., additional, Toral, Shastri M., additional, McDonnell, Shannon K., additional, Sarangi, Vivekananda, additional, Sinnwell, Jason P., additional, Asmann, Yan W., additional, Carrasquillo, Minerva M., additional, Pottier, Cyril P., additional, Ren, Yingxue, additional, Younkin, Curtis S., additional, Rademakers, Rosa, additional, Ross, Owen A., additional, Ertekin-Taner, Nilufer, additional, and Younkin, Steven G., additional

Published
2018
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13. P1‐160: ABI3 AND PLCG2 AS RISK FACTORS FOR ALZHEIMER'S DISEASE IN CAUCASIANS AND AFRICAN AMERICANS

Author

Conway, Olivia J., primary, Carrasquillo, Minerva M., additional, Bredenberg, Jenny M., additional, Reddy, Joseph S., additional, Younkin, Curtis S., additional, Allen, Mariet, additional, Nguyen, Thuy, additional, Lincoln, Sarah J., additional, Malphrus, Kimberly G., additional, Duara, Ranjan, additional, Greig Custo, Maria T., additional, Petersen, Ronald C., additional, Dickson, Dennis W., additional, Graff-Radford, Neill R., additional, and Ertekin-Taner, Nilufer, additional

Published
2018
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14. ＜Symposium IV＞Genetic variation in PCDH11X is associated with susceptibility to late onset Alzheimer's disease

Author

Carrasquillo, Minerva M., Zou, Fanggeng, Pankratz, V. Shane, Wilcox, Samantha L., Ma, Li, Walker, Louise P., Younkin, Samuel G., Younkin, Curtis S., Younkin, Linda H., Bisceglio, Gina D., Ertekin-Taner, Nilufer, Crook, Julia E., Dickson, Dennis W., Peterson, Rnald C., Graff-Radford, Neill R., and Younkin, Steven G.

Subjects
医学
Abstract

By analyzing late onset Alzheimer’s disease （LOAD） in a genome wide association study of 3 American Caucasian series and evaluating the 25 SNPs with most significant allelic association in 4 additional series, we identifi ed a SNP （rs5984894） on Xq21.3 in PCDH11X that is strongly associated with LOAD in American Caucasians （total n=4,855; AD:2,391; control:2,464）. Analysis of rs5984894 by logistic regression using sex as a covariate gave a global p value of 3.9 x 10-12 in the combined series. Odds ratios were 1.75（ 95% CI 1.42-2.16） for female homozygotes （P=2.0x10-7） and 1.26 （95% CI 1.05-1.51） for female heterozygotes （P=0.01） compared to female non-carriers. For male hemizygotes （P=0.07） compared to male non-carriers the odds ratio was 1.18 （95% CI 0.99-1.41）. The eff ect of this variant was dose dependent, as females homozygotes for the minor allele were at signifi cantly greater risk than heterozygous females and hemizygous males. We tested additional variants in PCDH11X for association with LOAD. One of these variants, rs2573905, showed association with LOAD similar to that for rs5984894, albeit with a slightly more significant p-value （5.4x10-13）. This is not surprising since these two variants are in near perfect linkage disequilibrium （r2 = 0.98, D’ = 0.99）, and the minor allele of these two SNPs occur on the same haplotype. However, rs2573905 is in a sequence that has been evolutionarily conserved between human and mice, with 70% sequence identity over 100bp, suggesting a possible functional role for this SNP. Joint analysis of APOE and rs2573905 genotypes showed that 75 women with LOAD （4.9%） were homozygous both for APOE e4 and for rs2573905 whereas only 2 unaff ected women （0.15%）, both age 73, were double homozygotes. These fi nding suggest that the double homozygote may be fully penetrant in women over the age of 73 and that this combination may account for ~5% of the AD that occurs in women., 弘前医学. 61(Suppl.), 2010, p.S125-S134

Published
2010

15. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases

Author

Allen, Mariet, primary, Wang, Xue, additional, Burgess, Jeremy D., additional, Watzlawik, Jens, additional, Serie, Daniel J., additional, Younkin, Curtis S., additional, Nguyen, Thuy, additional, Malphrus, Kimberly G., additional, Lincoln, Sarah, additional, Carrasquillo, Minerva M., additional, Ho, Charlotte, additional, Chakrabarty, Paramita, additional, Strickland, Samantha, additional, Murray, Melissa E., additional, Swarup, Vivek, additional, Geschwind, Daniel H., additional, Seyfried, Nicholas T., additional, Dammer, Eric B., additional, Lah, James J., additional, Levey, Allan I., additional, Golde, Todd E., additional, Funk, Cory, additional, Li, Hongdong, additional, Price, Nathan D., additional, Petersen, Ronald C., additional, Graff‐Radford, Neill R., additional, Younkin, Steven G., additional, Dickson, Dennis W., additional, Crook, Julia R., additional, Asmann, Yan W., additional, and Ertekin‐Taner, Nilüfer, additional

Published
2017
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16. [P4-074]: INTEGRATIVE SYSTEMS BIOLOGY APPROACH TO IDENTIFY NOVEL RISK FACTORS FOR PSP

Author

Allen, Mariet, primary, Wang, Xue, additional, Younkin, Curtis S., additional, Serie, Daniel, additional, Burgess, Jeremy D., additional, Nguyen, Thuy, additional, Lincoln, Sarah J., additional, Malphrus, Kimberly G., additional, Carrasquillo, Minerva M., additional, Kouri, Naomi, additional, Murray, Melissa E., additional, Schellenberg, Gerard D., additional, Younkin, Steven G., additional, Crook, Julia E., additional, Asmann, Yan W., additional, Dickson, Dennis W., additional, and Ertekin-Taner, Nilufer, additional

Published
2017
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17. USING TISSUE-BASED TRANSCRIPTOMICS TO PROFILE CELL TYPE VARIABILITY IN THE BRAIN

Author

Allen, Mariet, primary, Wang, Xue, additional, Reddy, Joseph S., additional, Carrasquillo, Minerva M., additional, Younkin, Curtis S., additional, Funk, Cory, additional, Burgess, Jeremy D., additional, Nguyen, Thuy, additional, Lincoln, Sarah J., additional, Malphrus, Kimberly G., additional, Asmann, Yan W., additional, Younkin, Steven G., additional, Price, Nathan D., additional, Golde, Todd E., additional, Dickson, Dennis W., additional, and Ertekin-Taner, Nilufer, additional

Published
2017
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18. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Author

Carrasquillo, Minerva M., primary, Allen, Mariet, additional, Burgess, Jeremy D., additional, Wang, Xue, additional, Strickland, Samantha L., additional, Aryal, Shivani, additional, Siuda, Joanna, additional, Kachadoorian, Michaela L., additional, Medway, Christopher, additional, Younkin, Curtis S., additional, Nair, Asha, additional, Wang, Chen, additional, Chanana, Pritha, additional, Serie, Daniel, additional, Nguyen, Thuy, additional, Lincoln, Sarah, additional, Malphrus, Kimberly G., additional, Morgan, Kevin, additional, Golde, Todd E., additional, Price, Nathan D., additional, White, Charles C., additional, De Jager, Philip L., additional, Bennett, David A., additional, Asmann, Yan W., additional, Crook, Julia E., additional, Petersen, Ronald C., additional, Graff‐Radford, Neill R., additional, Dickson, Dennis W., additional, Younkin, Steven G., additional, and Ertekin‐Taner, Nilüfer, additional

Published
2016
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19. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Author

Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Eaton, Matthew Lucas, Ernst, Jason, Meissner, Alexander, Kellis, Manolis, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Yu, Lei, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Younkin, Curtis, Zou, Fanggeng, Szyf, Moshe, Ertekin-Taner, Nilufer, Mill, Jonathan, De Jager, Philip L., Schalkwyk, Leonard C., Eaton, Matthew L., Keenan, Brendan T., Chai, High S., Younkin, Steven G., Epstein, Charles B., Schneider, Julie A., Bernstein, Bradley E., Chibnik, Lori B., Bennett, David A., Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Eaton, Matthew Lucas, Ernst, Jason, Meissner, Alexander, Kellis, Manolis, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Yu, Lei, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Younkin, Curtis, Zou, Fanggeng, Szyf, Moshe, Ertekin-Taner, Nilufer, Mill, Jonathan, De Jager, Philip L., Schalkwyk, Leonard C., Eaton, Matthew L., Keenan, Brendan T., Chai, High S., Younkin, Steven G., Epstein, Charles B., Schneider, Julie A., Bernstein, Bradley E., Chibnik, Lori B., and Bennett, David A.

Abstract

We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermore, we functionally validated these CpG associations and identified the nearby genes whose RNA expression was altered in AD: ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2. Our analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network., National Institutes of Health (U.S.) (Grant R01 AG036042), National Institutes of Health (U.S.) (Grant R01AG036836), National Institutes of Health (U.S.) (Grant R01 AG17917), National Institutes of Health (U.S.) (Grant R01AG15819), National Institutes of Health (U.S.) (Grant R01 AG032990), National Institutes of Health (U.S.) (Grant R01 AG18023), National Institutes of Health (U.S.) (Grant RC2 AG036547), National Institutes of Health (U.S.) (Grant P30 AG10161), National Institutes of Health (U.S.) (Grant P50 AG016574), National Institutes of Health (U.S.) (Grant U01 ES017155), National Institutes of Health (U.S.) (Grant KL2 RR024151), National Institutes of Health (U.S.) (Grant K25 AG041906-01)

Published
2016

20. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Author

Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Yu, Lei, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Younkin, Curtis, Zou, Fanggeng, Szyf, Moshe, Meissner, Alexander, Ertekin-Taner, Nilufer, Kellis, Manolis, Mill, Jonathan, De Jager, Philip L., Schalkwyk, Leonard C., Eaton, Matthew Lucas, Eaton, Matthew L., Keenan, Brendan T., Chai, High S., Younkin, Steven G., Epstein, Charles B., Schneider, Julie A., Bernstein, Bradley E., Chibnik, Lori B., Bennett, David A., Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Eaton, Matthew Lucas, Ernst, Jason, Meissner, Alexander, and Kellis, Manolis

Subjects
Male, Aging, Genome-wide association study, Neurodegenerative, Alzheimer's Disease, 80 and over, 2.1 Biological and endogenous factors, Psychology, Protein Interaction Maps, Aetiology, Epigenomics, Genetics, Aged, 80 and over, General Neuroscience, Intracellular Signaling Peptides and Proteins, Brain, Adaptor Proteins, Nuclear Proteins, Methylation, Amyloidosis, Middle Aged, 3. Good health, CpG site, Neurological, DNA methylation, Female, Cognitive Sciences, Alzheimer's disease, Ankyrins, and over, Biology, Article, Alzheimer Disease, Acquired Cognitive Impairment, medicine, Humans, Genetic Predisposition to Disease, Gene, Adaptor Proteins, Signal Transducing, Aged, Neurology & Neurosurgery, Tumor Suppressor Proteins, Human Genome, Signal Transducing, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), DNA Methylation, medicine.disease, Brain Disorders, Differentially methylated regions, Dementia, CpG Islands, Carrier Proteins, Genome-Wide Association Study
Abstract

We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermore, we functionally validated these CpG associations and identified the nearby genes whose RNA expression was altered in AD: ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2. Our analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network., National Institutes of Health (U.S.) (Grant R01 AG036042), National Institutes of Health (U.S.) (Grant R01AG036836), National Institutes of Health (U.S.) (Grant R01 AG17917), National Institutes of Health (U.S.) (Grant R01AG15819), National Institutes of Health (U.S.) (Grant R01 AG032990), National Institutes of Health (U.S.) (Grant R01 AG18023), National Institutes of Health (U.S.) (Grant RC2 AG036547), National Institutes of Health (U.S.) (Grant P30 AG10161), National Institutes of Health (U.S.) (Grant P50 AG016574), National Institutes of Health (U.S.) (Grant U01 ES017155), National Institutes of Health (U.S.) (Grant KL2 RR024151), National Institutes of Health (U.S.) (Grant K25 AG041906-01)

Published
2014

21. Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

Author

Allen, Mariet, primary, Carrasquillo, Minerva M., additional, Funk, Cory, additional, Heavner, Benjamin D., additional, Zou, Fanggeng, additional, Younkin, Curtis S., additional, Burgess, Jeremy D., additional, Chai, High-Seng, additional, Crook, Julia, additional, Eddy, James A., additional, Li, Hongdong, additional, Logsdon, Ben, additional, Peters, Mette A., additional, Dang, Kristen K., additional, Wang, Xue, additional, Serie, Daniel, additional, Wang, Chen, additional, Nguyen, Thuy, additional, Lincoln, Sarah, additional, Malphrus, Kimberly, additional, Bisceglio, Gina, additional, Li, Ma, additional, Golde, Todd E., additional, Mangravite, Lara M., additional, Asmann, Yan, additional, Price, Nathan D., additional, Petersen, Ronald C., additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Younkin, Steven G., additional, and Ertekin-Taner, Nilüfer, additional

Published
2016
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22. O2-10-04: A Regulatory Variant at the TREM Gene Cluster Associates with Decreased Alzheimer’s Disease Risk and Increased TREML1 and TREM2 Brain Gene Expression

Author

Carrasquillo, Minerva M., primary, Allen, Mariet, additional, Burgess, Jeremy D., additional, Strickland, Samantha L., additional, Aryal, Shivani, additional, Siuda, Joanna, additional, Kachadoorian, Michaela, additional, Medway, Christopher, additional, Younkin, Curtis S., additional, Nair, Asha, additional, Chanana, Pritha, additional, Wang, Xue, additional, Serie, Daniel, additional, Nguyen, Thuy, additional, Lincoln, Sarah, additional, Malphrus, Kimberly G., additional, Morgan, Kevin, additional, Golde, Todd E., additional, Price, Nathan D., additional, White, Charles, additional, de Jager, Philip, additional, Bennett, David A., additional, Asmann, Yan W., additional, Crook, Julia E., additional, Dickson, Dennis W., additional, Younkin, Steven G., additional, and Ertekin-Taner, Nilufer, additional

Published
2016
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23. F2-01-04: From Systems Level Transcriptomics to new Immune Targets for Alzheimer’s Disease

Author

Golde, Todd E., primary, Ertekin-Taner, Nilufer, additional, Chakrabarty, Paramita, additional, Allen, Mariet, additional, Carrasquillo, Minerva M., additional, Dickson, Dennis W., additional, Younkin, Steven G., additional, Levites, Yona, additional, Price, Nathan D., additional, Funk, Corey, additional, Heavner, Benjamen D., additional, Logsdon, Ben, additional, Mangravite, Lara M., additional, Li, Hong-Dong, additional, Burgess, Jeremy D., additional, Younkin, Curtis S., additional, Petersen, Ronald C., additional, Cruz, Pedro E., additional, Ceballos-Diaz, Carolina, additional, Rosario, Awilda M., additional, Adamson, Jeniffer, additional, Giasson, Benoit I., additional, Graff-Radford, Neill R., additional, Yachnis, Tony, additional, Zou, Fanggeng, additional, Eddy, James, additional, Crook, Julia E., additional, Wang, Xue, additional, Chai, High-Seng, additional, Serie, Daniel, additional, Wang, Chen, additional, Nguyen, Thuy, additional, Lincoln, Sarah, additional, Malphrus, Kimberly G., additional, Bisceglio, Gina, additional, Ma, Li, additional, and Asmann, Yan W., additional

Published
2016
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24. P4-048: Convergent Analysis of Endophenotypes in Progressive Supranuclear Palsy

Author

Allen, Mariet, primary, Wang, Xue, additional, Younkin, Curtis S., additional, Serie, Daniel, additional, Sun, Zhifu, additional, Burgess, Jeremy D., additional, Baheti, Saurabh, additional, Kouri, Naomi, additional, Nguyen, Thuy, additional, Lincoln, Sarah, additional, Malphrus, Kimberly G., additional, Carrasquillo, Minerva M., additional, Zou, Fanggeng, additional, Chai, High-Seng, additional, Murray, Melissa E., additional, Schellenberg, Gerard D., additional, Younkin, Steven G., additional, Crook, Julia E., additional, Ordog, Tamas, additional, Asmann, Yan W., additional, Dickson, Dennis W., additional, and Ertekin-Taner, Nilufer, additional

Published
2016
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25. POLYGENIC SCORE ANALYSIS OF EXONIC VARIANTS IN AN IMMUNE CO-REGULATORY NETWORK IDENTIFIES NOVEL PROTEIN-ALTERING VARIANTS THAT ASSOCIATE WITH ALZHEIMER’S DISEASE

Author

Reddy, Joseph S., Allen, Mariet, Wang, Xue, Biernacka, Joanna M., Gregory, Jenkins D., Toral, Shastri M., McDonnell, Shannon K., Sarangi, Vivekananda, Sinnwell, Jason P., Asmann, Yan W., Carrasquillo, Minerva M., Pottier, Cyril P., Ren, Yingxue, Younkin, Curtis S., Rademakers, Rosa, Ross, Owen A., Ertekin-Taner, Nilufer, and Younkin, Steven G.

Published
2018
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27. Late-onset Alzheimer disease risk variants mark brain regulatory loci

Author

Allen, Mariet, primary, Kachadoorian, Michaela, additional, Carrasquillo, Minerva M., additional, Karhade, Aditya, additional, Manly, Lester, additional, Burgess, Jeremy D., additional, Wang, Chen, additional, Serie, Daniel, additional, Wang, Xue, additional, Siuda, Joanna, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Medway, Christopher, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Petersen, Ronald C., additional, Graff-Radford, Neill R., additional, Asmann, Yan W., additional, Dickson, Dennis W., additional, Younkin, Steven G., additional, and Ertekin-Taner, Nilüfer, additional

Published
2015
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28. P2-025: Genetic and epigenetic influences on brain gene expression in psp

Author

Allen, Mariet, primary, Wang, Xue, additional, Younkin, Curtis S., additional, Burgess, Jeremy D., additional, Ballard, Travis, additional, Serie, Daniel, additional, Wang, Chen, additional, Sun, Zhifu, additional, Baheti, Saurabh, additional, Carrasquillo, Minerva M., additional, Nguyen, Thuy, additional, Malphrus, Kimberly G., additional, Lincoln, Sarah, additional, Zou, Fanggeng, additional, Chai, High-Seng, additional, Schellenberg, Gerard D., additional, Younkin, Steven G., additional, Crook, Julia, additional, Ordog, Tamas, additional, Asmann, Yan W., additional, Dickson, Dennis W., additional, and Taner, Nilufer, additional

Published
2015
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29. Assessing the effect of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on mRNA transcript levels, Alzheimer’s disease (AD) risk and cognitive performance (P2.163)

Author

Burgess, Jeremy, primary, Carrasquillo, Minerva, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Allen, Mariet, additional, Serie, Daniel, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Asmann, Yan, additional, Pedraza, Otto, additional, Roberts, Rosebud, additional, Lucas, John, additional, Smith, Glenn, additional, Ivnik, Robert, additional, Machulda, Mary, additional, Graff-Radford, Neill, additional, Petersen, Ronald, additional, Dickson, Dennis, additional, Younkin, Steven, additional, and Taner, Nilufer, additional

Published
2015
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30. O4-04-06: TRANSCRIPTIONAL REGULATION OF GENES AT THE ALZHEIMER'S DISEASE RISK LOCI

Author

Kachadoorian, Michaela, primary, Allen, Mariet, additional, Lincoln, Sarah, additional, Karhade, Aditya, additional, Manly, Lester, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pancratz, V. Shane, additional, Carrasquillo, Minerva M., additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Bisceglio, Gina, additional, Petersen, Ronald Carl, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Younkin, Steven, additional, and Ertekin-Taner, Nilufer, additional

Published
2014
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31. P3-022: TRANSCRIPTIONAL REGULATION AT THE TREM GENE CLUSTER IN AD BRAINS

Author

Carrasquillo, Minerva M., primary, Allen, Mariet, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pancratz, V. Shane, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Lincoln, Sarah, additional, Malphrus, Kimberly, additional, Bisceglio, Gina, additional, Petersen, Ronald Carl, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Younkin, Steven, additional, and Ertekin-Taner, Nilufer, additional

Published
2014
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32. O3-04-01: NEXT-GENERATION RNA SEQUENCING IN ALZHEIMER'S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY

Author

Ertekin-Taner, Nilufer, primary, Wang, Chen, additional, Carrasquillo, Minerva M., additional, Allen, Mariet, additional, Younkin, Curtis, additional, Serie, Daniel, additional, Wang, Xue, additional, Pancratz, V. Shane, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Petersen, Ronald Carl, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Younkin, Steven, additional, and Asmann, Yan, additional

Published
2014
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33. O3-04-06: GENE EXPRESSION PROFILING AND DNA METHYLATION IN ALZHEIMER'S DISEASE BRAINS

Author

Allen, Mariet, primary, Serie, Daniel, additional, Sun, Zhifu, additional, Baheti, Saurabh, additional, Walsh, Mike, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Siuda, Joanna, additional, Burgess, Jeremy, additional, Crook, Julia, additional, Pancratz, V. Shane, additional, Carrasquillo, Minerva M., additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Ordog, Tamas, additional, Petersen, Ronald Carl, additional, Dickson, Dennis W., additional, Graff-Radford, Neill R., additional, Younkin, Steven, additional, Asmann, Yan, additional, and Ertekin-Taner, Nilufer, additional

Published
2014
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34. Expression QTL Studies in LOAD and PSP Brains by Next-Generation RNA Sequencing (P2.147)

Author

Taner, Nilufer, primary, Wang, Chen, additional, Carrasquillo, Minerva, additional, Allen, Mariet, additional, Younkin, Curtis, additional, Serie, Daniel, additional, Pankratz, Vernon, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Younkin, Steven, additional, Dickson, Dennis, additional, and Asmann, Yan, additional

Published
2014
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35. Investigation Of Transcriptional Regulation At The Alzheimer’s Disease Risk Loci. (S28.006)

Author

Kachadoorian, Michaela, primary, Allen, Mariet, additional, Karhade, Aditya, additional, Manly, Lester, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Younkin, Steven, additional, Dickson, Dennis, additional, and Taner, Nilufer, additional

Published
2014
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36. Transcript Profiling Analysis Of Alzheimer’s Disease Brains. (S28.005)

Author

Allen, Mariet, primary, Serie, Daniel, additional, Walsh, Michael, additional, Zhifu, Sun, additional, Baheti, Saurabh, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Dickson, Dennis, additional, Younkin, Steven, additional, Asmann, Yan, additional, and Taner, Nilufer, additional

Published
2014
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37. Expression QTL Studies in LOAD and PSP Brains by Next-Generation RNA Sequencing (I5-1.009)

Author

Taner, Nilufer, primary, Wang, Chen, additional, Carrasquillo, Minerva, additional, Allen, Mariet, additional, Younkin, Curtis, additional, Serie, Daniel, additional, Pankratz, Vernon, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Younkin, Steven, additional, Dickson, Dennis, additional, and Asmann, Yan, additional

Published
2014
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38. Transcript Profiling Analysis Of Alzheimer’s Disease Brains. (I5-1.003)

Author

Allen, Mariet, primary, Serie, Daniel, additional, Walsh, Michael, additional, Zhifu, Sun, additional, Baheti, Saurabh, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Dickson, Dennis, additional, Younkin, Steven, additional, Asmann, Yan, additional, and Taner, Nilufer, additional

Published
2014
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39. Investigation Of Transcriptional Regulation At The Alzheimer’s Disease Risk Loci. (I5-2.004)

Author

Kachadoorian, Michaela, primary, Allen, Mariet, additional, Karhade, Aditya, additional, Manly, Lester, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Younkin, Steven, additional, Dickson, Dennis, additional, and Taner, Nilufer, additional

Published
2014
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40. CONVERGENT ANALYSIS OF ENDOPHENOTYPES IN PROGRESSIVE SUPRANUCLEAR PALSY

Author

Allen, Mariet, Wang, Xue, Younkin, Curtis S., Serie, Daniel, Sun, Zhifu, Burgess, Jeremy D., Baheti, Saurabh, Kouri, Naomi, Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly G., Carrasquillo, Minerva M., Zou, Fanggeng, Chai, High-Seng, Murray, Melissa E., Schellenberg, Gerard D., Younkin, Steven G., Crook, Julia E., Ordog, Tamas, Asmann, Yan W., Dickson, Dennis W., and Ertekin-Taner, Nilufer

Published
2016
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41. O5–01–05: Haplotypes at the MAPT locus associate with risk for LOAD and brain gene expression

Author

Allen, Mariet, primary, Kachadoorian, Michaela, additional, Quicksall, Zachary, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Krishnan, Siddarth, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff‐Radford, Neill, additional, Dickson, Dennis, additional, Younkin, Steven, additional, and Ertekin‐Taner, Nilufer, additional

Published
2013
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42. Investigation of MAPT Subhaplotypes as Risk Factors for Late-Onset Alzheimer's Disease (S34.003)

Author

Allen, Mariet, primary, Kachadoorian, Michaela, additional, Quicksall, Zachary, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Krishnan, Siddharth, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Dickson, Dennis, additional, Younkin, Steven, additional, and Taner, Nilufer, additional

Published
2013
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43. O5-03-03: Genetic association of progressive supranuclear palsy (PSP) risk loci variants with brain gene expression and neuropathology endophenotypes

Author

Ertekin-Taner, Nilufer, primary, Allen, Mariet, additional, Murray, Melissa, additional, Crook, Julia, additional, Serie, Daniel, additional, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Pankratz, Vernon, additional, Carrasquillo, Minerva, additional, Rowley, Christopher, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Palusak, Ryan, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Georgescu, Constantin, additional, Kouri, Naomi, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Schellenberg, Gerard, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Younkin, Steven, additional, and Dickson, Dennis, additional

Published
2012
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44. P1-201: Identification of human disease-associated variants in a brain expression genome-wide association study (eGWAS)

Author

Ertekin-Taner, Nilufer, primary, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Vernon, additional, Allen, Mariet, additional, Carrasquillo, Minerva, additional, Rowley, Christopher, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Palusak, Ryan, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Georgescu, Constantin, additional, Kouri, Naomi, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Dickson, Dennis, additional, and Younkin, Steven, additional

Published
2012
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45. P4-126: Genome-wide exploration of DNA methylation in the aging brain and its relation to Alzheimer's disease

Author

De Jager, Philip, primary, Srivastava, Gyan, additional, Eaton, Matthew, additional, Chibnik, Lori, additional, Keenan, Brendan, additional, Zou, Fangeng, additional, Song, High, additional, Younkin, Curtis, additional, Younkin, Steven, additional, Ertekin-Taner, Nilufer, additional, Bernstein, Brad, additional, Meissner, Alexander, additional, Kellis, Manolis, additional, and Bennett, David, additional

Published
2012
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46. Abstract 4926: Modeling the transcriptome landscape of HER2+ breast cancer

Author

Kalari, Krishna R., primary, Chai, High-Seng, additional, Asmann, Yan W., additional, Tang, Xiaojia, additional, Rossell, David, additional, Baheti, Saurabh, additional, Nair, Asha, additional, Baker, Tiffany R., additional, Necela, Brian M., additional, Carr, Jennifer M., additional, Hart, Steve N., additional, Sun, Zhifu, additional, Kachergus, Jennifer M., additional, Younkin, Curtis S., additional, Kocher, Jean-Pierre A., additional, Thompson, Aubrey E., additional, and Perez, Edith A., additional

Published
2012
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47. Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations

Author

Kalari, Krishna R., primary, Rossell, David, additional, Necela, Brian M., additional, Asmann, Yan W., additional, Nair, Asha, additional, Baheti, Saurabh, additional, Kachergus, Jennifer M., additional, Younkin, Curtis S., additional, Baker, Tiffany, additional, Carr, Jennifer M., additional, Tang, Xiaojia, additional, Walsh, Michael P., additional, Chai, High-Seng, additional, Sun, Zhifu, additional, Hart, Steven N., additional, Leontovich, Alexey A., additional, Hossain, Asif, additional, Kocher, Jean-Pierre, additional, Perez, Edith A., additional, Reisman, David N., additional, Fields, Alan P., additional, and Thompson, E. Aubrey, additional

Published
2012
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48. O3-01-08: Evaluation of known Alzheimer's genes for SNPs that influence their brain expression (eSNPs)

Author

Allen, Mariet, primary, Zou, Fanggeng, additional, Chai, High Seng, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Shane, additional, Carrasquillo, Minerva, additional, Rowley, Christopher, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Palusak, Ryan, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Georgescu, Constantin, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Dickson, Dennis, additional, Younkin, Steven, additional, and Ertekin-Taner, Nilufer, additional

Published
2011
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49. P1-229: Genome-Wide Association Study of Brain Gene Expression Levels (eGWAS)

Author

Ertekin-Taner, Nilufer, primary, Zou, Fanggeng, additional, Chai, High, additional, Younkin, Curtis, additional, Crook, Julia, additional, Pankratz, Shane, additional, Allen, Mariet, additional, Carrasquillo, Minerva, additional, Rowley, Christopher, additional, Pedraza, Otto, additional, Ansari, Morad, additional, Hayward, Caroline, additional, Rudan, Igor, additional, Campbell, Harry, additional, Polasek, Ozren, additional, Hastie, Nicholas, additional, Nair, Asha, additional, Middha, Sumit, additional, Maharjan, Sooraj, additional, Nguyen, Thuy, additional, Ma, Li, additional, Malphrus, Kimberly, additional, Palusak, Ryan, additional, Lincoln, Sarah, additional, Bisceglio, Gina, additional, Georgescu, Constantin, additional, Kolbert, Christopher, additional, Jen, Jin, additional, Wszolek, Zbigniew, additional, Barcikowska, Maria, additional, Sando, Sigrid, additional, Aasly, Jan, additional, Morgan, Kevin, additional, Jack, Clifford, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Wright, Alan, additional, Dickson, Dennis, additional, and Younkin, Steven, additional

Published
2011
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50. O2‐07‐07: eSNPs within VAMP1 show genetic association with late onset Alzheimer's disease

Author

Zou, Fanggeng, primary, Allen, Mariet, additional, Belbin, Olivia, additional, Hunter, Talisha, additional, Ma, Li, additional, Bisceglio, Gina, additional, Carrasquillo, Minerva, additional, Younkin, Curtis, additional, Petersen, Ronald, additional, Graff-Radford, Neill, additional, Dickson, Dennis, additional, Deak, Ferenc, additional, and Younkin, Steven, additional

Published
2010
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