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1. An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Author

Vacca, Michele, Kamzolas, Ioannis, Harder, Lea Mørch, Oakley, Fiona, Trautwein, Christian, Hatting, Maximilian, Ross, Trenton, Bernardo, Barbara, Oldenburger, Anouk, Hjuler, Sara Toftegaard, Ksiazek, Iwona, Lindén, Daniel, Schuppan, Detlef, Rodriguez-Cuenca, Sergio, Tonini, Maria Manuela, Castañeda, Tamara R., Kannt, Aimo, Rodrigues, Cecília M. P., Cockell, Simon, Govaere, Olivier, Daly, Ann K., Allison, Michael, Honnens de Lichtenberg, Kristian, Kim, Yong Ook, Lindblom, Anna, Oldham, Stephanie, Andréasson, Anne-Christine, Schlerman, Franklin, Marioneaux, Jonathon, Sanyal, Arun, Afonso, Marta B., Younes, Ramy, Amano, Yuichiro, Friedman, Scott L., Wang, Shuang, Bhattacharya, Dipankar, Simon, Eric, Paradis, Valérie, Burt, Alastair, Grypari, Ioanna Maria, Davies, Susan, Driessen, Ann, Yashiro, Hiroaki, Pors, Susanne, Worm Andersen, Maja, Feigh, Michael, Yunis, Carla, Bedossa, Pierre, Stewart, Michelle, Cater, Heather L., Wells, Sara, Schattenberg, Jörn M., Anstee, Quentin M., Tiniakos, Dina, Perfield, James W., Petsalaki, Evangelia, Davidsen, Peter, and Vidal-Puig, Antonio

Published
2024
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3. Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Author

Rosso, Chiara, Caviglia, Gian Paolo, Birolo, Giovanni, Armandi, Angelo, Pennisi, Grazia, Pelusi, Serena, Younes, Ramy, Liguori, Antonio, Perez-Diaz-del-Campo, Nuria, Nicolosi, Aurora, Govaere, Olivier, Castelnuovo, Gabriele, Olivero, Antonella, Abate, Maria Lorena, Ribaldone, Davide Giuseppe, Fariselli, Piero, Valenti, Luca, Miele, Luca, Petta, Salvatore, Romero-Gomez, Manuel, Anstee, Quentin M., and Bugianesi, Elisabetta

Published
2023
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4. Validation of the Blood Test MACK-3 for the Noninvasive Diagnosis of Fibrotic Nonalcoholic Steatohepatitis: An International Study With 1924 Patients

Author

Canivet, Clémence M., Zheng, Ming-Hua, Qadri, Sami, Vonghia, Luisa, Chuah, Kee-Huat, Costentin, Charlotte, George, Jacob, Armandi, Angelo, Adams, Leon A., Lange, Naomi F., Blanchet, Odile, Moal, Valérie, Younes, Ramy, Roux, Marine, Chan, Wah-Kheong, Sturm, Nathalie, Eslam, Mohammed, Bugianesi, Elisabetta, Wang, Zhengyi, Dufour, Jean-François, Francque, Sven, Yki-Järvinen, Hannele, Zheng, Kenneth I., and Boursier, Jérôme

Published
2023
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5. Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Author

Anstee, Quentin M, Daly, Ann K, Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J, Day, Christopher P, Wonders, Kristy, Missier, Paolo, McTeer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M, Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G, Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M, Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K, Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioannis, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J, Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, McGlinchey, Aiden, Mato, Jose M, Millet, Óscar, Dufour, Jean-François, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Rasmussen, Daniel Guldager Kring, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattias, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M P, Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andreas, Trautwein, Christian, Reißing, Johanna, Aithal, Guruprasad P, Francis, Susan, Palaniyappan, Naaventhan, Bradley, Christopher, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W, Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, McLeod, Euan James, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Coxson, Harvey, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Kjær, Mette Skalshøi, Harder, Lea Mørch, Davidsen, Peter, Ellegaard, Jens, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Douglas, Shankar, Sudha, Torstenson, Richard, Lindén, Daniel, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D, Billin, Andrew, Doward, Lynda, Twiss, James, Thakker, Paresh, Derdak, Zoltan, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, Mózes, Ferenc E, Lee, Jenny A, Alzoubi, Osama, Staufer, Katharina, Trauner, Michael, Paternostro, Rafael, Stauber, Rudolf E, van Dijk, Anne-Marieke, Mak, Anne Linde, de Saint Loup, Marc, Shima, Toshihide, Gaia, Silvia, Shalimar, Lupșor-Platon, Monica, Wong, Vincent Wai-Sun, Li, Guanlin, Wong, Grace Lai-Hung, Karlas, Thomas, Wiegand, Johannes, Sebastiani, Giada, Tsochatzis, Emmanuel, Liguori, Antonio, Yoneda, Masato, Nakajima, Atsushi, Hagström, Hannes, Akbari, Camilla, Hirooka, Masashi, Chan, Wah-Kheong, Mahadeva, Sanjiv, Rajaram, Ruveena, Zheng, Ming-Hua, George, Jacob, Eslam, Mohammed, Viganò, Mauro, Ridolfo, Sofia, Aithal, Guruprasad Padur, Lee, Dae Ho, Nasr, Patrik, Cassinotto, Christophe, de Lédinghen, Victor, Mendoza, Yuly P, Noureddin, Mazen, Truong, Emily, and Harrison, Stephen A

Published
2023
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6. A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis

Author

Sanyal, Arun J., primary, Bedossa, Pierre, additional, Fraessdorf, Mandy, additional, Neff, Guy W., additional, Lawitz, Eric, additional, Bugianesi, Elisabetta, additional, Anstee, Quentin M., additional, Hussain, Samina Ajaz, additional, Newsome, Philip N., additional, Ratziu, Vlad, additional, Hosseini-Tabatabaei, Azadeh, additional, Schattenberg, Jörn M., additional, Noureddin, Mazen, additional, Alkhouri, Naim, additional, and Younes, Ramy, additional

Published
2024
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7. GS-006 Glucagon and GLP-1 receptor dual agonist survodutide improved liver histology in people with MASH and fibrosis: Results from a randomized, double-blind, placebo-controlled phase 2 trial

Author

Sanyal, Arun J, primary, Bedossa, Pierre, additional, Fraessdorf, Mandy, additional, Neff, Guy, additional, Lawitz, Eric, additional, Bugianesi, Elisabetta, additional, Anstee, Quentin M., additional, Hussain, Samina Ajaz, additional, Newsome, Philip N., additional, Ratziu, Vlad, additional, Hosseini-Tabatabaei, Azadeh, additional, Schattenberg, Jörn M, additional, Noureddin, Mazen, additional, Alkhouri, Naim, additional, and Younes, Ramy, additional

Published
2024
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9. OS-119 Survodutide (BI 456906), a glucagon receptor/glucagon-like peptide-1 receptor (GCGR/GLP-1R) dual agonist, in people with compensated and decompensated cirrhosis: a multinational, open-label, phase 1 trial

Author

Lawitz, Eric, primary, Fraessdorf, Mandy, additional, Neff, Guy, additional, Schattenberg, Jörn M, additional, Noureddin, Mazen, additional, Alkhouri, Naim, additional, Schmid, Bernhard, additional, Andrews, Charles P., additional, Takács, István, additional, Hussain, Samina Ajaz, additional, Fenske, Wiebke K., additional, Gane, Edward J., additional, Hosseini-Tabatabaei, Azadeh, additional, Sanyal, Arun J, additional, Mazo, Daniel, additional, and Younes, Ramy, additional

Published
2024
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12. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Author

Clark, James, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, Hyötyläinen, Tuulia, McGlinchey, Aidan, Orešič, Matej, Sen, Partho, Mato, Jose, Millet, Óscar, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Pereira Rodrigues, Cecília Maria, Hanf, Rémy, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla, Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Kjær, Mette Skalshøi, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Fournier, Céline, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, Twiss, James, Johnson, Katherine, Leary, Peter J., Govaere, Olivier, Barter, Matthew J., Charlton, Sarah H., Cockell, Simon J., Tiniakos, Dina, Zatorska, Michalina, Bedossa, Pierre, Brosnan, M. Julia, Cobbold, Jeremy F., Ekstedt, Mattias, Aithal, Guruprasad P., Clément, Karine, Schattenberg, Jörn M., Boursier, Jerome, Ratziu, Vlad, Bugianesi, Elisabetta, Anstee, Quentin M., and Daly, Ann K.

Published
2022
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14. SURVODUTIDE REDUCES LIVER FAT CONTENT, TRANSAMINASES, AND FIBROSIS MARKERS WITH GOOD SAFETY PROFILE IN PEOPLE WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH): AN INTERIM ANALYSIS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2 TRIAL

Author

Alkhouri, Naim, primary, Fraessdorf, Mandy, additional, Neff, Guy, additional, Schattenberg, Joern M., additional, Noureddin, Mazen, additional, Lawitz, Eric, additional, Anstee, Ǫuentin M., additional, Bugianesi, Elisabetta, additional, Hussain, Samina Ajaz, additional, Newsome, Philip, additional, Ratziu, Vlad, additional, Hosseini-Tabatabaei, Azadeh, additional, Sanyal, Arun J., additional, and Younes, Ramy, additional

Published
2024
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16. Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver Disease

Author

Petta, Salvatore, Sebastiani, Giada, Viganò, Mauro, Ampuero, Javier, Wai-Sun Wong, Vincent, Boursier, Jerome, Berzigotti, Annalisa, Bugianesi, Elisabetta, Fracanzani, Anna Ludovica, Cammà, Calogero, Enea, Marco, Grottes, Marraud des, Di Marco, Vito, Younes, Ramy, Keyrouz, Aline, Mazzola, Sergio, Mendoza, Yuly, Pennisi, Grazia, Romero-Gomez, Manuel, Craxì, Antonio, and de Ledinghen, Victor

Published
2021
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17. Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease

Author

Armandi, Angelo, Sanavia, Tiziana, Younes, Ramy, Caviglia, Gian Paolo, Rosso, Chiara, Govaere, Olivier, Liguori, Antonio, Francione, Paolo, Gallego-Duran, Rocio, Ampuero, Javier, Pennisi, Grazia, Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio, Maggioni, Marco, Cabibi, Daniela, Mcleod, Duncan, Pareja, Maria Jesus, Zaki, Marco Y. W., Stal, Per, Kechagias, Stergios, Fracanzani, Anna Ludovica, Valenti, Luca, Grieco, Antonio, Miele, Luca, Fariselli, Piero, Eslam, Mohammed, Petta, Salvatore, Hagstroem, Hannes, George, Jacob, Schattenberg, Joern M., Romero-Gomez, Manuel, Anstee, Quentin Mark, Bugianesi, Elisabetta, Armandi, Angelo, Sanavia, Tiziana, Younes, Ramy, Caviglia, Gian Paolo, Rosso, Chiara, Govaere, Olivier, Liguori, Antonio, Francione, Paolo, Gallego-Duran, Rocio, Ampuero, Javier, Pennisi, Grazia, Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio, Maggioni, Marco, Cabibi, Daniela, Mcleod, Duncan, Pareja, Maria Jesus, Zaki, Marco Y. W., Stal, Per, Kechagias, Stergios, Fracanzani, Anna Ludovica, Valenti, Luca, Grieco, Antonio, Miele, Luca, Fariselli, Piero, Eslam, Mohammed, Petta, Salvatore, Hagstroem, Hannes, George, Jacob, Schattenberg, Joern M., Romero-Gomez, Manuel, Anstee, Quentin Mark, and Bugianesi, Elisabetta

Abstract

Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD., Funding Agencies|Italian Ministry for Education, University and Research (MIUR) [D15D18000410001]; PNRR M4C2I1.3 Heal Italia project [PE00000019 CUP B73C22001250006]; Ministry of Health [PNRR-MAD- 2022-12375656, RF- 2021-12372399, PRIN-2022 2022L273C9]; Robert W. Storr Bequest [RF- 2021-12374481]; National Health and Medical Research Council of Australia (NHMRC); Cancer Institute, NSW grant [APP1053206, APP2001692, APP1107178, APP1108422, APP1196492]; [2021/ATRG2028]

Published
2024
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18. NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Author

Pfister, Dominik, Núñez, Nicolás Gonzalo, Pinyol, Roser, Govaere, Olivier, Pinter, Matthias, Szydlowska, Marta, Gupta, Revant, Qiu, Mengjie, Deczkowska, Aleksandra, Weiner, Assaf, Müller, Florian, Sinha, Ankit, Friebel, Ekaterina, Engleitner, Thomas, Lenggenhager, Daniela, Moncsek, Anja, Heide, Danijela, Stirm, Kristin, Kosla, Jan, Kotsiliti, Eleni, Leone, Valentina, Dudek, Michael, Yousuf, Suhail, Inverso, Donato, Singh, Indrabahadur, Teijeiro, Ana, Castet, Florian, Montironi, Carla, Haber, Philipp K., Tiniakos, Dina, Bedossa, Pierre, Cockell, Simon, Younes, Ramy, Vacca, Michele, Marra, Fabio, Schattenberg, Jörn M., Allison, Michael, Bugianesi, Elisabetta, Ratziu, Vlad, Pressiani, Tiziana, D’Alessio, Antonio, Personeni, Nicola, Rimassa, Lorenza, Daly, Ann K., Scheiner, Bernhard, Pomej, Katharina, Kirstein, Martha M., Vogel, Arndt, Peck-Radosavljevic, Markus, Hucke, Florian, Finkelmeier, Fabian, Waidmann, Oliver, Trojan, Jörg, Schulze, Kornelius, Wege, Henning, Koch, Sandra, Weinmann, Arndt, Bueter, Marco, Rössler, Fabian, Siebenhüner, Alexander, De Dosso, Sara, Mallm, Jan-Philipp, Umansky, Viktor, Jugold, Manfred, Luedde, Tom, Schietinger, Andrea, Schirmacher, Peter, Emu, Brinda, Augustin, Hellmut G., Billeter, Adrian, Müller-Stich, Beat, Kikuchi, Hiroto, Duda, Dan G., Kütting, Fabian, Waldschmidt, Dirk-Thomas, Ebert, Matthias Philip, Rahbari, Nuh, Mei, Henrik E., Schulz, Axel Ronald, Ringelhan, Marc, Malek, Nisar, Spahn, Stephan, Bitzer, Michael, Ruiz de Galarreta, Marina, Lujambio, Amaia, Dufour, Jean-Francois, Marron, Thomas U., Kaseb, Ahmed, Kudo, Masatoshi, Huang, Yi-Hsiang, Djouder, Nabil, Wolter, Katharina, Zender, Lars, Marche, Parice N., Decaens, Thomas, Pinato, David J., Rad, Roland, Mertens, Joachim C., Weber, Achim, Unger, Kristian, Meissner, Felix, Roth, Susanne, Jilkova, Zuzana Macek, Claassen, Manfred, Anstee, Quentin M., Amit, Ido, Knolle, Percy, Becher, Burkhard, Llovet, Josep M., and Heikenwalder, Mathias

Published
2021
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20. Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease

Author

Armandi, Angelo, primary, Sanavia, Tiziana, additional, Younes, Ramy, additional, Caviglia, Gian Paolo, additional, Rosso, Chiara, additional, Govaere, Olivier, additional, Liguori, Antonio, additional, Francione, Paolo, additional, Gallego-Duràn, Rocìo, additional, Ampuero, Javier, additional, Pennisi, Grazia, additional, Aller, Rocio, additional, Tiniakos, Dina, additional, Burt, Alastair, additional, David, Ezio, additional, Vecchio, Fabio, additional, Maggioni, Marco, additional, Cabibi, Daniela, additional, McLeod, Duncan, additional, Pareja, Maria Jesus, additional, Zaki, Marco Y W, additional, Grieco, Antonio, additional, Stål, Per, additional, Kechagias, Stergios, additional, Fracanzani, Anna Ludovica, additional, Valenti, Luca, additional, Miele, Luca, additional, Fariselli, Piero, additional, Eslam, Mohammed, additional, Petta, Salvatore, additional, Hagström, Hannes, additional, George, Jacob, additional, Schattenberg, Jörn M, additional, Romero-Gómez, Manuel, additional, Anstee, Quentin Mark, additional, and Bugianesi, Elisabetta, additional

Published
2024
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25. Impact of PNPLA3 rs738409 polymorphism on the development of liver-related events in patients with non-alcoholic fatty liver disease

Author

Rosso, Chiara, primary, Caviglia, Gian Paolo, additional, Birolo, Giovanni, additional, Armandi, Angelo, additional, Pennisi, Grazia, additional, Pelusi, Serena, additional, Younes, Ramy, additional, Liguori, Antonio, additional, Perez-Diaz-del-Campo, Nuria, additional, Nicolosi, Aurora, additional, Govaere, Olivier, additional, Castelnuovo, Gabriele, additional, Olivero, Antonella, additional, Abate, Maria Lorena, additional, Ribaldone, Davide Giuseppe, additional, Fariselli, Piero, additional, Valenti, Luca, additional, Miele, Luca, additional, Petta, Salvatore, additional, Romero-Gomez, Manuel, additional, Anstee, Quentin M., additional, and Bugianesi, Elisabetta, additional

Published
2023
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26. Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes

Author

Pennisi, Grazia, primary, Enea, Marco, additional, Falco, Vincenzo, additional, Aithal, Guruprasad P., additional, Palaniyappan, Naaventhan, additional, Yilmaz, Yusuf, additional, Boursier, Jerome, additional, Cassinotto, Christophe, additional, de Lédinghen, Victor, additional, Chan, Wah Kheong, additional, Mahadeva, Sanjiv, additional, Eddowes, Peter, additional, Newsome, Philip, additional, Karlas, Thomas, additional, Wiegand, Johannes, additional, Wong, Vincent Wai-Sun, additional, Schattenberg, Jörn M., additional, Labenz, Christian, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Lupsor-Platon, Monica, additional, Cobbold, Jeremy F. L., additional, Fan, Jian-Gao, additional, Shen, Feng, additional, Staufer, Katharina, additional, Trauner, Michael, additional, Stauber, Rudolf, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Gaia, Silvia, additional, Zheng, Ming-Hua, additional, Cammà, Calogero, additional, Anstee, Quentin M., additional, Mózes, Ferenc Emil, additional, Pavlides, Michael, additional, and Petta, Salvatore, additional

Published
2023
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27. Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study

Author

Jenny, Lee, Max, Westphal, Yasaman, Vali, Jerome, Boursier, Salvatorre, Petta, Rachel, Ostroff, Leigh, Alexander, Yu, Chen, Celine, Fournier, Andreas, Geier, Sven, Francque, Kristy, Wonder, Dina, Tiniako, Pierre, Bedossa, Mike, Allison, Georgios, Papatheodoridi, Helena, Cortez-Pinto, Raluca, Pai, Jean-Francois, Dufour, Diana Julie, Leeming, Stephen, Harrison, Jeremy, Cobbold, Adriaan G, Holleboom, Hannele, Yki-Järvinen, Javier, Crespo, Mattias, Ekstedt, Guruprasad P, Aithal, Elisabetta, Bugianesi, Manuel, Romero-Gomez, Richard, Torstenson, Morten, Karsdal, Carla, Yuni, Jörn M, Schattenberg, Detlef, Schuppan, Vlad, Ratziu, Clifford, Bra, Kevin, Duffin, Koos, Zwinderman, Michael, Pavlide, Quentin M, Anstee, Patrick M, Bossuyt, Anstee, Quentin M., Daly, Ann K., Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J., Day, Christopher P., Wonders, Kristy, Missier, Paolo, Mcteer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G., Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M., Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K., Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioanni, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J., Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, Mcglinchey, Aiden, Mato, Jose M., Millet, Óscar, Dufour, Jean-Françoi, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Guldager Kring Rasmussen, Daniel, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattia, Kechagias, Stergio, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M. P., Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andrea, Trautwein, Christian, Aithal, Guruprasad P., Francis, Susan, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W., Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, Mcleod, Euan Jame, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Skalshøi Kjær, Mette, Mørch Harder, Lea, Davidsen, Peter, Mikkelsen, Lars Frii, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Dougla, Shankar, Sudha, Torstenson, Richard, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D., Billin, Andrew, Doward, Lynda, Twiss, Jame, Thakker, Paresh, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, Luca, Miele (ORCID:0000-0003-3464-0068), Jenny, Lee, Max, Westphal, Yasaman, Vali, Jerome, Boursier, Salvatorre, Petta, Rachel, Ostroff, Leigh, Alexander, Yu, Chen, Celine, Fournier, Andreas, Geier, Sven, Francque, Kristy, Wonder, Dina, Tiniako, Pierre, Bedossa, Mike, Allison, Georgios, Papatheodoridi, Helena, Cortez-Pinto, Raluca, Pai, Jean-Francois, Dufour, Diana Julie, Leeming, Stephen, Harrison, Jeremy, Cobbold, Adriaan G, Holleboom, Hannele, Yki-Järvinen, Javier, Crespo, Mattias, Ekstedt, Guruprasad P, Aithal, Elisabetta, Bugianesi, Manuel, Romero-Gomez, Richard, Torstenson, Morten, Karsdal, Carla, Yuni, Jörn M, Schattenberg, Detlef, Schuppan, Vlad, Ratziu, Clifford, Bra, Kevin, Duffin, Koos, Zwinderman, Michael, Pavlide, Quentin M, Anstee, Patrick M, Bossuyt, Anstee, Quentin M., Daly, Ann K., Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J., Day, Christopher P., Wonders, Kristy, Missier, Paolo, Mcteer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G., Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M., Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K., Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioanni, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J., Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, Mcglinchey, Aiden, Mato, Jose M., Millet, Óscar, Dufour, Jean-Françoi, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Guldager Kring Rasmussen, Daniel, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattia, Kechagias, Stergio, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M. P., Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andrea, Trautwein, Christian, Aithal, Guruprasad P., Francis, Susan, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W., Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, Mcleod, Euan Jame, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Skalshøi Kjær, Mette, Mørch Harder, Lea, Davidsen, Peter, Mikkelsen, Lars Frii, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Dougla, Shankar, Sudha, Torstenson, Richard, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D., Billin, Andrew, Doward, Lynda, Twiss, Jame, Thakker, Paresh, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, and Luca, Miele (ORCID:0000-0003-3464-0068)

Abstract

Background and aims: Detecting NASH remains challenging, while at-risk NASH (steatohepatitis and F≥ 2) tends to progress and is of interest for drug development and clinical application. We developed prediction models by supervised machine learning techniques, with clinical data and biomarkers to stage and grade patients with NAFLD. Approach and results: Learning data were collected in the Liver Investigation: Testing Marker Utility in Steatohepatitis metacohort (966 biopsy-proven NAFLD adults), staged and graded according to NASH CRN. Conditions of interest were the clinical trial definition of NASH (NAS ≥ 4;53%), at-risk NASH (NASH with F ≥ 2;35%), significant (F ≥ 2;47%), and advanced fibrosis (F ≥ 3;28%). Thirty-five predictors were included. Missing data were handled by multiple imputations. Data were randomly split into training/validation (75/25) sets. A gradient boosting machine was applied to develop 2 models for each condition: clinical versus extended (clinical and biomarkers). Two variants of the NASH and at-risk NASH models were constructed: direct and composite models.Clinical gradient boosting machine models for steatosis/inflammation/ballooning had AUCs of 0.94/0.79/0.72. There were no improvements when biomarkers were included. The direct NASH model produced AUCs (clinical/extended) of 0.61/0.65. The composite NASH model performed significantly better (0.71) for both variants. The composite at-risk NASH model had an AUC of 0.83 (clinical and extended), an improvement over the direct model. Significant fibrosis models had AUCs (clinical/extended) of 0.76/0.78. The extended advanced fibrosis model (0.86) performed significantly better than the clinical version (0.82). Conclusions: Detection of NASH and at-risk NASH can be improved by constructing independent machine learning models for each component, using only clinical predictors. Adding biomarkers only improved the accuracy of fibrosis.

Published
2023

28. Cross-Sectional and Longitudinal Performance of Non-Invasive Tests of Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Author

Armandi, Angelo, primary, Rosso, Chiara, additional, Younes, Ramy, additional, Leeming, Diana Julie, additional, Karsdal, Morten A., additional, Caviglia, Gian Paolo, additional, Pérez-Diaz-del-Campo, Nuria, additional, D’Amato, Daphne, additional, Abdulle, Amina, additional, Nicolosi, Aurora, additional, Castelnuovo, Gabriele, additional, Saracco, Giorgio Maria, additional, Ribaldone, Davide Giuseppe, additional, and Bugianesi, Elisabetta, additional

Published
2023
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29. Validation of the blood test MACK-3 for the noninvasive diagnosis of fibrotic NASH: an international study with 1,924 patients

Author

Canivet, Clémence M, Zheng, Ming-Hua, Qadri, Sami, Vonghia, Luisa, Chuah, Kee-Huat, Costentin, Charlotte, George, Jacob, Armandi, Angelo, Adams, Leon A, Lange, Naomi F, Blanchet, Odile, Moal, Valérie, Younes, Ramy, Roux, Marine, Chan, Wah-Kheong, Sturm, Nathalie, Eslam, Mohammed, Bugianesi, Elisabetta, Wang, Zhengyi, Dufour, Jean-François, Francque, Sven, Yki-Järvinen, Hannele, Zheng, Kenneth I, and Boursier, Jérôme

Subjects
610 Medizin und Gesundheit
Abstract

BACKGROUND AND AIMS Drug development in NASH is hampered by a high screening failure rate that reaches 60-80% in therapeutic trials, mainly because of the absence of fibrotic NASH on baseline liver histology. MACK-3, a blood test including three biomarkers (aspartate aminotransferase, homeostasis model assessment and cytokeratin 18), was recently developed for the noninvasive diagnosis of fibrotic NASH. We aimed to validate the diagnostic accuracy of this noninvasive test in an international multicenter study. METHODS 1,924 patients with biopsy-proven NAFLD from 10 centers in Asia, Australia, and Europe were included. The blood test MACK-3 was calculated for all patients. FAST, an elastography-based test for fibrotic NASH, was also available in a subset of 655 patients. Fibrotic NASH was defined as the presence of NASH on liver biopsy with NAFLD Activity Score ≥4 and fibrosis stage F≥2 according to the NASH CRN scoring system. RESULTS AUROC of MACK-3 for fibrotic NASH was 0.791 [0.768-0.814]. Sensitivity at the previously published MACK-3 threshold of 0.549 threshold was 85%. The MACK-3 AUROC was not affected by age, sex, diabetes, or BMI. MACK-3 and FAST results were well correlated (Rs=0.781, P < .001). Except an 8% higher rate of patients included in the grey zone, MACK-3 provided similar accuracy to that of FAST. Both tests included 27% of patients in their rule-in zone, with 85% specificity and 35% false positives (screen failure rate). CONCLUSION The blood test MACK-3 is an accurate tool to improve patient selection in NASH therapeutic trials.

Published
2023
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30. 241 - Glucagon and GLP-1 receptor dual agonist survodutide improved liver histology in people with MASH and fibrosis: Results from a randomized, double-blind, placebo-controlled phase 2 trial

Author

Nelson, Morag, Sanyal, Arun J, Bedossa, Pierre, Fraessdorf, Mandy, Neff, Guy W, Lawitz, Eric, Bugianesi, Elisabetta, Anstee, Quentin M, Hussain, Samina Ajaz, Newsome, Philip N, Ratziu, Vlad, Hosseini-Tabatabaei, Azadeh, Schattenberg, Joern M, Noureddin, Mazen, Alkhouri, Naim, and Younes, Ramy

Published
2024
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31. Determinants of liver stiffness measurements in patients with NAFLD-an individual patient data meta-analysis

Author

Mozes, Ferenc, primary, Selvaraj, Emmanuel, additional, Jayaswal, Arjun, additional, Boursier, Jerome, additional, Fournier, Céline, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Petta, Salvatore, additional, Mahadeva, Sanjiv, additional, Chan, Wah-Kheong, additional, Eddowes, Peter, additional, Newsome, Philip N., additional, Hirschfield, Gideon, additional, Wong, Vincent Wai-Sun, additional, de Lédinghen, Victor, additional, Cobbold, Jeremy, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Cassinotto, Cristophe, additional, Ooi, Geraldine, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Zheng, Ming-Hua, additional, Geier, Andreas, additional, Tuthill, Theresa, additional, Brosnan, M.Juli, additional, Anstee, Quentin, additional, Harrison, Stephen, additional, Bossuyt, Patrick, additional, and Pavlides, Michael, additional

Published
2022
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32. Diagnostic accuracy of non-invasive tests for fibrotic NASH-An individual participant data meta-analysis

Author

Mozes, Ferenc, primary, Lee, Jenny, additional, Vali, Yasaman, additional, Selvaraj, Emmanuel, additional, Jayaswal, Arjun, additional, Boursier, Jerome, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Lupsor-Platon, Monica, additional, Petta, Salvatore, additional, Shima, Toshihide, additional, Okanoue, Takeshi, additional, Mahadeva, Sanjiv, additional, Chan, Wah-Kheong, additional, Hirschfield, Gideon, additional, Eddowes, Peter, additional, Newsome, Philip N., additional, Wong, Vincent Wai-Sun, additional, de Lédinghen, Victor, additional, Cobbold, Jeremy, additional, Sumida, Yoshio, additional, Okajima, Akira, additional, Schattenberg, Jörn, additional, Labenz, Christian, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Aithal, Guruprasad, additional, Palaniyappan, Naaventhan, additional, Cassinotto, Cristophe, additional, Aggarwal, Sandeep, additional, Garg, Harshit, additional, Ooi, Geraldine, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Zheng, Ming-Hua, additional, Fournier, Céline, additional, Trauner, Michael, additional, Geier, Andreas, additional, Tuthill, Theresa, additional, Yunis, Carla, additional, Anstee, Quentin, additional, Harrison, Stephen, additional, Bossuyt, Patrick, additional, and Pavlides, Michael, additional

Published
2022
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33. Diagnostic accuracy of non-invasive tests for cirrhotic NASH-an individual participant data meta-analysis

Author

Mozes, Ferenc, primary, Lee, Jenny, additional, Vali, Yasaman, additional, Selvaraj, Emmanuel, additional, Jayaswal, Arjun, additional, Boursier, Jerome, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Lupsor-Platon, Monica, additional, Petta, Salvatore, additional, Shima, Toshihide, additional, Okanoue, Takeshi, additional, Mahadeva, Sanjiv, additional, Chan, Wah-Kheong, additional, Hirschfield, Gideon, additional, Eddowes, Peter, additional, Newsome, Philip N., additional, Wong, Vincent Wai-Sun, additional, de Lédinghen, Victor, additional, Cobbold, Jeremy, additional, Sumida, Yoshio, additional, Okajima, Akira, additional, Schattenberg, Jörn, additional, Labenz, Christian, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Aithal, Guruprasad, additional, Palaniyappan, Naaventhan, additional, Cassinotto, Cristophe, additional, Aggarwal, Sandeep, additional, Garg, Harshit, additional, Ooi, Geraldine, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Zheng, Ming-Hua, additional, Fournier, Céline, additional, Geier, Andreas, additional, Tuthill, Theresa, additional, Yunis, Carla, additional, Anstee, Quentin, additional, Harrison, Stephen, additional, Bossuyt, Patrick, additional, and Pavlides, Michael, additional

Published
2022
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34. Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

Author

Govaere, Olivier, Kragh Petersen, Sine, Martinez-Lopez, Nuria, Wouters, Jasper, Van Haele, Matthias, Mancina, Rosellina M., Jamialahmadi, Oveis, Bilkei-Gorzo, Orsolya, Bel Lassen, Pierre, Darlay, Rebecca, Peltier, Julien, Palmer, Jeremy M., Younes, Ramy, Tiniakos, Dina, Aithal, Guruprasad P., Allison, Michael, Vacca, Michele, Berlinguer-Palmini, Rolando, Clark, James E., Drinnan, Michael J., Dufour, Jean-Francois, Ekstedt, Mattias, Francque, Sven, Petta, Salvatore, Bugianesi, Elisabetta, Day, Christopher P., Cordell, Heather J., Topal, Baki, Romeo, Stefano, Ratziu, Vlad, Roskams, Tania, Daly, Ann K., Anstee, Quentin M., and Trost, Matthias

Subjects
macrophages, immunometabolism, NASH, inflammation
Abstract

Background & Aims: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely understood. Methods: 170 NAFLD liver biopsies were processed for transcriptomic analysis and correlated with clinicopathological features. Msr1-/- and WT mice were submitted to a 16 week high-fat and high-cholesterol diet. Therapeutic intervention with monoclonal antibody against MSR1 was performed in mice and ex vivo human liver slices. Genetic susceptibility was assessed using GWAS data from 1,483 NAFLD patients and 430,101 participants of the UKBiobank. Results: MSR1 expression was associated with the occurrence of hepatic lipid-laden foamy macrophages and correlated with the degree of steatosis and steatohepatitis in NAFLD patients. Mice lacking Msr1 were protected against diet-induced metabolic disorder, showing fewer hepatic foamy macrophages, less hepatic inflammation, improved dyslipidemia and glucose tolerance, while showing altered hepatic lipid metabolism. MSR1 induced a pro-inflammatory response via the JNK signalling pathway upon triggering by saturated fatty acids. In vitro blockade of the receptor prevented the accumulation of lipids in primary macrophages which inhibited the switch towards a pro-inflammatory phenotype and the release of cytokines such as TNF-?. Targeting MSR1 using monoclonal antibody therapy in an obesity-associated NAFLD mouse model and human liver slices resulted in the prevention of foamy macrophage formation and inflammation. Moreover, we identified that rs41505344, a polymorphism in the upstream transcriptional region of MSR1, was associated with altered serum triglycerides and aspartate transaminase levels in a cohort of over 400,000 patients. Conclusions: Taken together, our data suggest a critical role for MSR1 in lipid-induced inflammation and a potential therapeutic target for the treatment of NAFLD.

Published
2022

35. Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

Author

European Commission, NIHR Biomedical Research Centre (UK), Ministero della Salute, Sydney Medical Foundation, University of Sydney, National Health and Medical Research Council (Australia), Younes, Ramy, Govaere, Olivier, Petta, Salvatore, Miele, Luca, Tiniakos, Dina, Burt, Alastair, Davis, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, McLeod, Duncan, Pareja, María Jesús, Fracanzani, Anna Ludovica, Aller, Rocío, Rosso, Chiara, Ampuero, Javier, Gallego-Durán, Rocío, Armandi, Angelo, Caviglia, Gian Paolo, Zaki, Marco Y. W., Liguori, Antonio, Francione, Paolo, Pennisi, Grazia, Grieco, Antonio, Birolo, Giovanni, Fariselli, Piero, Eslam, Mohammed, Valenti, Luca, George, Jacob, Romero-Gómez, Manuel, Anstee, Quentin M., Bugianesi, Elisabetta, European Commission, NIHR Biomedical Research Centre (UK), Ministero della Salute, Sydney Medical Foundation, University of Sydney, National Health and Medical Research Council (Australia), Younes, Ramy, Govaere, Olivier, Petta, Salvatore, Miele, Luca, Tiniakos, Dina, Burt, Alastair, Davis, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, McLeod, Duncan, Pareja, María Jesús, Fracanzani, Anna Ludovica, Aller, Rocío, Rosso, Chiara, Ampuero, Javier, Gallego-Durán, Rocío, Armandi, Angelo, Caviglia, Gian Paolo, Zaki, Marco Y. W., Liguori, Antonio, Francione, Paolo, Pennisi, Grazia, Grieco, Antonio, Birolo, Giovanni, Fariselli, Piero, Eslam, Mohammed, Valenti, Luca, George, Jacob, Romero-Gómez, Manuel, Anstee, Quentin M., and Bugianesi, Elisabetta

Abstract

[Objective] The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis of Caucasian lean subjects with NAFLD., [Design] The study cohort comprises 1339 biopsy-proven NAFLD subjects from four countries (Italy, UK, Spain and Australia), stratified into lean and non-lean (body mass index (BMI) 10 483 person-years), 4.7% of lean vs 7.7% of non-lean patients reported liver-related events (p=0.37). No difference in survival was observed compared with non-lean NAFLD (p=0.069)., [Conclusions] Caucasian lean subjects with NAFLD may progress to advanced liver disease, develop metabolic comorbidities and experience cardiovascular disease (CVD) as well as liver-related mortality, independent of longitudinal progression to obesity and PNPLA3 genotype. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD where the disease manifests at lower overall BMI thresholds. [Lay summary] NAFLD may affect and progress in both obese and lean individuals. Lean subjects are predominantly males, have a younger age at diagnosis and are more prevalent in some geographic areas. During the follow-up, lean subjects can develop hepatic and extrahepatic disease, including metabolic comorbidities, in the absence of weight gain. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD.

Published
2022

36. Global multi-stakeholder endorsement of the MAFLD definition

Author

Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, Rolf, Tharwat, Mostafa, Thong, Vo Duy, Thursz, Mark, Tine, Tulari, Tiribelli, Claudio, Tolmane, Ieva, Tong, Jing, Tongo, Marco, Torkie, Mamdouh, Torre, Aldo, Torres, Esther A, Trajkovska, Meri, Treeprasertsuk, Sombat, Tsutsumi, Tsubasa, Tu, Thomas, Tur, Josep A., Turan, Dilara, Turcan, Svetlana, Turkina, Svetlana, Tutar, Engin, Tzeuton, Christian, Ugiagbe, Rose, Uygun, Ahmet, Vacca, Michele, Vajro, Pietro, Van der Poorten, David, Van Kleef, Laurens A., Vashakidze, Eliza, Velazquez, Carlos Moctezuma, Velazquez, Mirtha Infante, Vento, Sandro, Verhoeven, Veronique, Vespasiani-Gentilucci, Umberto, Vethakkan, Shireene Ratna, Vilaseca, Josep, Vítek, Libor, Volkanovska, Ance, Wallace, Michael, Wan, Wang, Wang, Yan, Wang, Ying, Wang, Xiaolin, Wang, Xuemei, Wang, Chengyan, Wang, Chunjiong, Wang, Mingjie, Wangchuk, Pelden, Weltman, Martin, White, MaryFrances, Wiegand, Johannes, Wifi, Mohamed-Naguib, Wigg, Alan, Wilhelmi, Markus, William, Remon, Wittenburg, Henning, Wu, Shengjie, Wubeneh, Abdu Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, Zuart Ruiz, Roberto, Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, and Eslam, Mohammed

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2022
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37. Global multi-stakeholder endorsement of the MAFLD definition

Author

Méndez-Sánchez, Nahum, primary, Bugianesi, Elisabetta, additional, Gish, Robert G, additional, Lammert, Frank, additional, Tilg, Herbert, additional, Nguyen, Mindie H, additional, Sarin, Shiv K, additional, Fabrellas, Núria, additional, Zelber-Sagi, Shira, additional, Fan, Jian-Gao, additional, Shiha, Gamal, additional, Targher, Giovanni, additional, Zheng, Ming-Hua, additional, Chan, Wah-Kheong, additional, Vinker, Shlomo, additional, Kawaguchi, Takumi, additional, Castera, Laurent, additional, Yilmaz, Yusuf, additional, Korenjak, Marko, additional, Spearman, C Wendy, additional, Ungan, Mehmet, additional, Palmer, Melissa, additional, El-Shabrawi, Mortada, additional, Gruss, Hans-Juergen, additional, Dufour, Jean-François, additional, Dhawan, Anil, additional, Wedemeyer, Heiner, additional, George, Jacob, additional, Valenti, Luca, additional, Fouad, Yasser, additional, Romero‐Gomez, Manuel, additional, Eslam, Mohammed, additional, Abate, Maria Lorena, additional, Abbas, Bahaa, additional, Abbassy, Ahmed Amr, additional, Abd El Ghany, Waleed, additional, Abd Elkhalek, Amira, additional, Abd ElMajeed, Emad, additional, Abdalgaber, Mohammad, additional, AbdAllah, Mohamed, additional, Abdallah, Marwa, additional, Abdallah, Nourhan, additional, Abdelaleem, Shereen, additional, Abdelghani, Yasser, additional, Abdelghany, Wael, additional, Abdelhalim, Safaa Mohamed, additional, Abdelhamid, Wafaa, additional, Abdelhamid, Nehal, additional, Abdelkader, Nadia A., additional, Abdelkreem, Elsayed, additional, Abdelmohsen, Aly Mohamed, additional, Abdelrahman, Awny Ali, additional, Abd-elsalam, Sherief M, additional, Abdeltawab, Doaa, additional, Abduh, Abdulbaset, additional, Abdulhakam, Nada, additional, Abdulla, Maheeba, additional, Abedpoor, Navid, additional, Abenavoli, Ludovico, additional, Åberg, Fredrik, additional, Ablack, Omala, additional, Abo elftouh, Mostafa, additional, Abo-Amer, Yousry Esam-Eldin, additional, Aboubkr, Ashraf, additional, Aboud, Alaa, additional, Abouelnaga, Amr M., additional, Aboufarrag, Galal A., additional, Aboutaleb, Ashraf, additional, Abundis, Leticia, additional, Adalı, Gupse, additional, Adames, Enrique, additional, Adams, Leon, additional, Adda, Danjuma, additional, Adel, Noor, additional, Adel, Nada, additional, Adel Sayed, Muhammad, additional, Afaa, Taiba Jibril, additional, Afredj, Nawal, additional, Aghayeva, Gulnara, additional, Aghemo, Alessio, additional, Aguilar-Salinas, Carlos A., additional, Ahlenstiel, Golo, additional, Ahmady, Walid, additional, Ahmed, Wafaa, additional, Ahmed, Amira, additional, Ahmed, Samah Nasser, additional, Ahmed, Heba Mostafa, additional, Ahmed, Rasha, additional, Aigner, Elmar, additional, Akarsu, Mesut, additional, Akroush, Maisam, additional, Akyuz, Umit, additional, Al Mahtab, Mamun, additional, Al Qadiri, Tahani, additional, Al Rawahi, Yusriya, additional, AL rubaee, Razzaq, additional, Al Saffar, Muna, additional, Alam, Shahinul, additional, Al-Ani, Zaid, additional, Albillos, Agustín, additional, Alboraie, Mohamed, additional, Al-Busafi, Said, additional, Al-Emam, Mohamed, additional, Alharthi, Jawaher, additional, Ali, Kareem, additional, Ali, Basma Abdelmoez, additional, Ali, Mohammad, additional, Ali, Raja Affendi Raja, additional, Alisi, Anna, additional, AL-Khafaji, Ali Raad, additional, Alkhatry, Maryam, additional, Aller, Rocio, additional, Almansoury, Yahya, additional, Al-Naamani, Khalid, additional, Alnakeeb, Alaa, additional, Alonso, Anna, additional, Alqahtani, Saleh A., additional, Alrabadi, Leina, additional, Alswat, Khalid, additional, Altaher, Mahir, additional, Altamimi, Turki, additional, Altamirano, Jose, additional, Alvares-da-Silva, Mario R., additional, Aly, Elsragy Adel M., additional, Alzahaby, Amgad, additional, Alzamzamy, Ahmed, additional, Amano, Keisuke, additional, Amer, Maysa A., additional, Amin, Mona A., additional, Amin, Sayed A., additional, Amir, Ashraf A., additional, Ampuero, Javier, additional, Anas, Noha, additional, Andreone, Pietro, additional, Andriamandimby, Soa Fy, additional, Anees, Mahmoud, additional, Angela, Peltec, additional, Antonios, Manal, additional, Arafat, Wael, additional, Araya, Jose Moreno, additional, Armendariz-Borunda, Juan, additional, Armstrong, Matthew J., additional, Ashktorab, Hassan, additional, Aspichueta, Patricia, additional, Assal, Fathia, additional, Atef, Mira, additional, Attia, Dina, additional, Atwa, Hoda, additional, Awad, Reham, additional, Awad, Mohyeldeen Abd Elaziz, additional, Awny, Sally, additional, Awolowo, Obafemi, additional, Awuku, Yaw Asante, additional, Ayada, Ibrahim, additional, Aye, Than Than, additional, Ayman, Sherif, additional, Ayman, Hedy, additional, Ayoub, Hesham, additional, Azmy, Hosny M., additional, Babaran, Romiro P., additional, Badreldin, Omneya, additional, Badry, Ahmed, additional, Bahçecioğlu, İbrahim Halil, additional, Bahour, Amira, additional, Bai, Jiajia, additional, Balaban, Yasemin, additional, Balasubramanyam, Muthuswamy, additional, Bamakhrama, Khaled, additional, Banales, Jesus M, additional, Bangaru, Babu, additional, Bao, Jianfeng, additional, Barahona, Jorge Suazo, additional, Barakat, Salma, additional, Barbalho, Sandra Maria, additional, Barbra, Bikwa, additional, Barranco, Beatriz, additional, Barrera, Francisco, additional, Baumann, Ulrich, additional, Bazeed, Shamardan, additional, Bech, Eva, additional, Benayad, Aourarh, additional, Benesic, Andreas, additional, Bernstein, David, additional, Bessone, Fernando, additional, Birney, Susie, additional, Bisseye, Cyrille, additional, Blake, Martin, additional, Bobat, Bilal, additional, Bonfrate, Leonilde, additional, Bordin, Dmitry S, additional, Bosques-Padilla, Francisco, additional, Boursier, Jerome, additional, Boushab, Boushab Mohamed, additional, Bowen, David, additional, Bravo, Patricia Medina, additional, Brennan, Paul N, additional, Bright, Bisi, additional, Broekaert, Ilse, additional, Buque, Xabier, additional, Burgos-Santamaría, Diego, additional, Burman, Julio, additional, Busetto, Luca, additional, Byrne, Chris D., additional, Cabral-Prodigalidad, Patricia Anne I., additional, Cabrera-Alvarez, Guillermo, additional, Cai, Wei, additional, Cainelli, Francesca, additional, Caliskan, Ali Riza, additional, Canbay, Ali, additional, Cano-Contreras, Ana, additional, Cao, Hai-Xia, additional, Cao, Zhujun, additional, Carrion, Andres, additional, Carubbi, Francesca, additional, Casanovas, Teresa, additional, Castellanos Fernández, Marlen Ivón, additional, Chai, Jin, additional, Chan, Siew Pheng, additional, Charatcharoenwitthaya, Phunchai, additional, Chavez-Tapia, Norberto, additional, Chayama, Kazuaki, additional, Chen, Jinjun, additional, Chen, Lin, additional, Chen, Zhong-Wei, additional, Chen, Huiting, additional, Chen, Sui-Dan, additional, Chen, Qiang, additional, Chen, Yaxi, additional, Chen, Gang, additional, Chen, En-Quang, additional, Chen, Fei, additional, Chen, Pei-Jer, additional, Cheng, Robert, additional, Cheng, Wendy, additional, Chieh, Jack Tan Wei, additional, Chokr, Imad, additional, Cholongitas, Evangelos, additional, Choudhury, Ashok, additional, Chowdhury, Abhijit, additional, Chukwudike, Evaristus Sunday, additional, Ciardullo, Stefano, additional, Clayton, Michelle, additional, Clement, Karine, additional, Cloa, Marie Michelle, additional, Coccia, Cecilia, additional, Collazos, Cristina, additional, Colombo, Massimo, additional, Cosar, Arif Mansur, additional, Cotrim, Helma Pinchemel, additional, Couillerot, Joris, additional, Coulibaly, Alioune, additional, Crespo, Gonzalo, additional, Crespo, Javier, additional, Cruells, Maria, additional, Cua, Ian Homer Y., additional, Dabbous, Hesham K., additional, Dalekos, George N, additional, D'Alia, Patricia, additional, Dan, Li, additional, Dao, Viet Hang, additional, Darwish, Mostafa, additional, Datz, Christian, additional, Davalos-Moscol, Milagros B, additional, Dawoud, Heba, additional, de Careaga, Blanca Olaechea, additional, de Knegt, Robert, additional, de Ledinghen, Victor, additional, de Silva, Janaka, additional, Debzi, Nabil, additional, Decraecker, Marie, additional, Del Pozo, Elvira, additional, Delgado, Teresa C, additional, Delgado-Blanco, Manuel, additional, Dembiński, Łukasz, additional, Depina, Adilson, additional, Derbala, Moutaz, additional, Desalegn, Hailemichael, additional, Desbois-Mouthon, Christèle, additional, Desoky, Mahmoud, additional, Dev, Anouk, additional, Di Ciaula, Agostino, additional, Diago, Moisés, additional, Diallo, Ibrahima, additional, Díaz, Luis Antonio, additional, Dirchwolf, Melisa, additional, Dongiovanni, Paola, additional, Dorofeyev, Andrriy, additional, Dou, Xiaoguang, additional, Douglas, Mark W., additional, Doulberis, Michael, additional, Dovia, Cecil K., additional, Doyle, Adam, additional, Dragojević, Ivana, additional, Drenth, Joost PH, additional, Duan, Xuefei, additional, Dulskas, Audrius, additional, Dumitrascu, Dan L, additional, Duncan, Oliver, additional, Dusabejambo, Vincent, additional, Dwawhi, Rev. Shem N.A., additional, Eiketsu, Sho, additional, El Amrousy, Doaa, additional, El Deeb, Ahmed, additional, El Deriny, Ghada, additional, El Din, Hesham Salah, additional, El Kamshishy, Salwa, additional, El Kassas, Mohamed, additional, El Raziky, Maissa, additional, Elagamy, Osama A, additional, Elakel, Wafaa, additional, Elalfy, Dina, additional, Elaraby, Hanaa, additional, ElAwady, Heba, additional, Elbadawy, Reda, additional, Eldash, Hanaa Hassan, additional, Eldefrawy, Manal S., additional, Elecharri, Carol Lezama, additional, Elfaramawy, Amel, additional, Elfatih, Mohammed, additional, Elfiky, Mahmoud, additional, Elgamsy, Mohamed, additional, Elgendy, Mohamed, additional, El-Guindi, Mohamed A., additional, Elhussieny, Nagi, additional, Eliwa, Ahmed Maher, additional, Elkabbany, Zeineb, additional, El-Khayat, Hesham, additional, El-Koofy, Nehal M., additional, Elmetwalli, Alaa, additional, Elrabat, Amr, additional, El-Raey, Fathiya, additional, Elrashdy, Fatma, additional, Elsahhar, Medhat, additional, Elsaid, Esraa M., additional, Elsayed, Shimaa, additional, Elsayed, Hany, additional, Elsayed, Aly, additional, Elsayed, Amr M., additional, Elsayed, Hamdy, additional, El-Serafy, Magdy, additional, Elsharkawy, Ahmed M., additional, Elsheemy, Reem Yehia, additional, Elshemy, Eman Elsayed, additional, Elsherbini, Sara, additional, Eltoukhy, Naglaa, additional, Elwakil, Reda, additional, Emad, Ola, additional, Emad, Shaimaa, additional, Embabi, Mohamed, additional, Ergenç, Ilkay, additional, Ermolova, Tatiana, additional, Esmat, Gamal, additional, Esmat, Doaa M., additional, Estupiñan, Enrique Carrera, additional, Ettair, Said, additional, Eugen, Tcaciuc, additional, Ezz-Eldin, Mohammed, additional, Falcón, Lidia Patricia Valdivieso, additional, Fan, Yu-Chen, additional, Fandari, Samah, additional, Farag, Mahmoud, additional, Farahat, Taghreed Mohamed, additional, Fares, Eman M., additional, Fares, Michael, additional, Fassio, Eduardo, additional, Fathy, Hayam, additional, Fathy, Dina, additional, Fathy, Wael, additional, Fayed, Soheir, additional, Feng, Dan, additional, Feng, Gong, additional, Fernández-Bermejo, Miguel, additional, Ferreira, Cristina Targa, additional, Ferrer, Javier Díaz, additional, Forbes, Alastair, additional, Fouad, Rabab, additional, Fouad, Hanan M., additional, Frisch, Tove, additional, Fujii, Hideki, additional, Fukunaga, Shuhei, additional, Fukunishi, Shinya, additional, Fulya, Hacer, additional, Furuhashi, Masato, additional, Gaber, Yasmine, additional, Galang, Augusto Jose G., additional, Gallardo, Jacqueline Cordova, additional, Galloso, Rocío, additional, Gamal, Mahmoud, additional, Gamal, Reham, additional, Gamal, Hadeel, additional, Gan, Jian, additional, Ganbold, Anar, additional, Gao, Xin, additional, Garas, George, additional, Garba, Tony, additional, García-Cortes, Miren, additional, García-Monzón, Carmelo, additional, García-Samaniego, Javier, additional, Gastaldelli, Amalia, additional, Gatica, Manuel, additional, Gatley, Elizabeth, additional, Gegeshidze, Tamar, additional, Geng, Bin, additional, Ghazinyan, Hasmik, additional, Ghoneem, Salma, additional, Giacomelli, Luca, additional, Giannelli, Gianluigi, additional, Giannini, Edoardo G., additional, Giefer, Matthew, additional, Ginès, Pere, additional, Girala, Marcos, additional, Giraudi, Pablo J, additional, Goh, George Boon-Bee, additional, Gomaa, Ahmed Ali, additional, Gong, Benbingdi, additional, Gonzales, Dina Hilda C., additional, Gonzalez, Humberto C., additional, Gonzalez-Huezo, Maria Saraí, additional, Graupera, Isabel, additional, Grgurevic, Ivica, additional, Grønbæk, Henning, additional, Gu, Xuelian, additional, Guan, Lin, additional, Gueye, Ibrahima, additional, Guingané, Alice Nanelin, additional, Gul, Ozen Oz, additional, Gul, Cuma Bulent, additional, Guo, Qing, additional, Gupta, Pramendra Prasad, additional, Gurakar, Ahmet, additional, Gutierrez, Juan Carlos Restrepo, additional, Habib, Ghada, additional, Hafez, Azaa, additional, Hagman, Emilia, additional, Halawa, Eman, additional, Hamdy, Osama, additional, Hamed, Abd Elkhalek, additional, Hamed, Dina H., additional, Hamid, Saeed, additional, Hamoudi, Waseem, additional, Han, Yu, additional, Haridy, James, additional, Haridy, Hanan, additional, Harris, David C H Harris, additional, Hart, Michael, additional, Hasan, Fuad, additional, Hashim, Almoutaz, additional, Hassan, Israa, additional, Hassan, Ayman, additional, Hassan, Essam Ali, additional, Hassan, Adel Ahmed, additional, Hassan, Magda Shehata, additional, Hassanin, Fetouh, additional, Hassnine, Alshymaa, additional, Haukeland, John Willy, additional, Hawal, Amr Ismael M., additional, He, Jinfan, additional, He, Qiong, additional, He, Yong, additional, He, Fang-Ping, additional, Hegazy, Mona, additional, Hegazy, Adham, additional, Henegil, Osama, additional, Hernández, Nelia, additional, Hernández-Guerra, Manuel, additional, Higuera-de-la-Tijera, Fatima, additional, Hindy, Ibrahim, additional, Hirota, Keisuke, additional, Ho, Lee Chi, additional, Hodge, Alexander, additional, Hosny, Mohamed, additional, Hou, Xin, additional, Huang, Jiao-Feng, additional, Huang, Yan, additional, Huang, Zhifeng, additional, Huang, Yuan, additional, Huang, Ang, additional, Huang, Xiao-Ping, additional, Hui-ping, Sheng, additional, Hunyady, Bela, additional, Hussein, Mennatallah A., additional, Hussein, Osama, additional, Hussien, Shahinaz Mahmoud, additional, Ibáñez-Samaniego, Luis, additional, Ibdah, Jamal, additional, Ibrahim, Luqman, additional, Ibrahim, Miada, additional, Ibrahim, Ibrahim, additional, Icaza-Chávez, Maria E., additional, Idelbi, Sahar, additional, Idilman, Ramazan Idilman, additional, Ikeda, Mayumi, additional, Indolfi, Giuseppe, additional, Invernizzi, Federica, additional, Irshad, Iram, additional, Isa, Hasan Mohamed Ali, additional, Iskandar, Natacha Jreige, additional, Ismaiel, Abdulrahman, additional, Ismail, Mariam, additional, Ismail, Zulkifli, additional, Ismail, Faisal, additional, Iwamoto, Hideki, additional, Jack, Kathryn, additional, Jacob, Rachael, additional, Jafarov, Fuad, additional, Jafri, Wasim, additional, Jahshan, Helen, additional, Jalal, Prasun K, additional, Jancoriene, Ligita, additional, Janicko, Martin, additional, Jayasena, Hiruni, additional, Jefferies, Meryem, additional, Jha, Vivekanand, additional, Ji, Fanpu, additional, Ji, Yaqiu, additional, Jia, Jidong, additional, Jiang, Changtao, additional, Jiang, Ni, additional, Jiang, Zong-zhe, additional, Jin, Xing, additional, Jin, Yi, additional, Jing, Xu, additional, Jingyu, Qian, additional, Jinjolava, Maia, additional, Jong, FX Himawan Haryanto, additional, Jucov, Alina, additional, Julius, Ibecheole, additional, Kaddah, Mona, additional, Kamada, Yoshihiro, additional, kamal, Abobakr, additional, Kamal, Enas Mohamed, additional, Kamel, Ashraf Sayed, additional, Kao, Jia-Horng, additional, Karin, Maja, additional, Karlas, Thomas, additional, Kashwaa, Mohammad, additional, Katsidzira, Leolin, additional, Kaya, Eda, additional, Kayasseh, M.Azzam, additional, Keenan, Bernadette, additional, Keklikkiran, Caglayan, additional, Keml, William, additional, Khalaf, Deia K., additional, Khalefa, Rofida, additional, Khamis, Sherin, additional, Khater, Doaa, additional, khattab, Hamed, additional, Khavkin, Anatoly, additional, Khlynova, Olga, additional, Khmis, Nabil, additional, Kobyliak, Nazarii, additional, Koffas, Apostolos, additional, Koike, Kazuhiko, additional, Kok, Kenneth Y.Y., additional, Koller, Tomas, additional, Komas, Narcisse Patrice, additional, Korochanskaya, Nataliya V., additional, Koulla, Yannoula, additional, Koya, Shunji, additional, Kraft, Colleen, additional, Kraja, Bledar, additional, Krawczyk, Marcin, additional, Kuchay, Mohammad Shafi, additional, Kulkarni, Anand V, additional, Kumar, Ashish, additional, Kumar, Manoj, additional, Lakoh, Sulaiman, additional, Lam, Philip, additional, Lan, Ling, additional, Lange, Naomi F., additional, Lankarani, Kamran Bagheri, additional, Lanthier, Nicolas, additional, Lapshyna, Kateryna, additional, Lashen, Sameh A., additional, Laure, Konang Nguieguia Justine, additional, Lazebnik, Leonid, additional, Lebrec, Didier, additional, Lee, Samuel S., additional, Lee, Way Seah, additional, Lee, Yeong Yeh, additional, Leeming, Diana Julie, additional, Leite, Nathalie Carvalho, additional, Leon, Roberto, additional, Lesmana, Cosmas Rinaldi Adithya, additional, Li, Junfeng, additional, Li, Qiong, additional, Li, Jun, additional, Li, Yang-Yang, additional, Li, Yufang, additional, Li, Lei, additional, Li, Min, additional, li, Yiling, additional, Liang, Huiqing, additional, Lijuan, Tang, additional, Lim, Seng Gee, additional, Lim, Lee-Ling, additional, Lin, Shumei, additional, Lin, Han-Chieh, additional, Lin, Rita, additional, Lithy, Rania, additional, Liu, Yaru, additional, Liu, Yuanyuan, additional, Liu, Xin, additional, Liu, Wen-Yue, additional, Liu, Shourong, additional, Liu, Ken, additional, Liu, Tian, additional, Lonardo, Amedeo, additional, López, Mariana Bravo, additional, López-Benages, Eva, additional, Lopez-Jaramillo, Patricio, additional, Lu, Huimin, additional, Lu, Lun Gen, additional, Lu, Yan, additional, Lubel, John, additional, Lui, Rashid, additional, Lupasco, Iulianna, additional, Luzina, Elena, additional, Lv, Xiao-Hui, additional, Lynch, Kate, additional, Ma, Hong-Lei, additional, Machado, Mariana Verdelho, additional, Maduka, Nonso, additional, Madzharova, Katerina, additional, Magdaong, Russellini, additional, Mahadeva, Sanjiv, additional, Mahfouz, Amel, additional, Mahmood, Nik Ritza Kosai Nik, additional, Mahmoud, Eman, additional, Mahrous, Mohamed, additional, Maiwall, Rakhi, additional, Majeed, Ammar, additional, Majumdar, Avik, additional, Mak, Loey, additional, Maklouf, Madiha M, additional, Malekzadeh, Reza, additional, Mandato, Claudia, additional, Mangia, Alessandra, additional, Mann, Jake, additional, Mansour, Hala Hussien, additional, Mansouri, Abdellah, additional, Mantovani, Alessandro, additional, Mao, Jun qian, additional, Maramag, Flor, additional, Marchesini, Giulio, additional, Marcus, Claude, additional, Marinho, Rui António Rocha Tato, additional, Martinez-Chantar, Maria L, additional, Martins, Antonieta A. Soares, additional, Marwan, Rana, additional, Mason, Karen Frances, additional, Masoud, Ghadeer, additional, Massoud, Mohamed Naguib, additional, Matamoros, Maria Amalia, additional, Mateos, Rosa Martín, additional, Mawed, Asmaa, additional, Mbanya, Jean Claude, additional, Mbendi, Charles, additional, McColaugh, Lone, additional, McLeod, Duncan, additional, Medina, Juan Francisco Rivera, additional, Megahed, Ahmed, additional, Mehrez, Mai, additional, Memon, Iqbal, additional, Merat, Shahin, additional, Mercado, Randy, additional, Mesbah, Ahmed, additional, Meskini, Taoufik, additional, Metwally, Mayada, additional, Metwaly, Rasha, additional, Miao, Lei, additional, Micah, Eileen, additional, Miele, Luca, additional, Milivojevic, Vladimir, additional, Milovanovic, Tamara, additional, Mina, Yvonne L., additional, Mishkovik, Milan, additional, Mishriki, Amal, additional, Mitchell, Tim, additional, Mohamed, Alshaimaa, additional, Mohamed, Mona, additional, Mohamed, Sofain, additional, Mohammed, Shady, additional, Mohammed, Ahmed, additional, Mohan, Viswanathan, additional, Mohie, Sara, additional, Mokhtar, Aalaa, additional, Moniem, Reham, additional, Montilla, Mabel Segura, additional, Morales, Jose Antonio Orozco, additional, Morata, María María Sánchez, additional, Moreno-Planas, Jose Maria, additional, Morise, Silvia, additional, Mosaad, Sherif, additional, Moselhy, Mohamed, additional, Mostafa, Alaa Mohamed, additional, Mostafa, Ebraheem, additional, Mouane, Nezha, additional, Mousa, Nasser, additional, Moustafa, Hamdy Mahfouz, additional, Msherif, Abeer, additional, Muller, Kate, additional, Munoz, Christopher, additional, Muñoz-Urribarri, Ana Beatriz, additional, Murillo, Omar Alfaro, additional, Mustapha, Feisul Idzwan, additional, Muzurović, Emir, additional, Nabil, Yehia, additional, Nafady, Shaymaa, additional, Nagamatsu, Ayu, additional, Nakajima, Atsushi, additional, Nakano, Dan, additional, Nan, Yuemin, additional, Nascimbeni, Fabio, additional, Naseef, Mirella S., additional, Nashat, Nagwa, additional, Natalia, Taran, additional, Negro, Francesco, additional, Nersesov, Alexander V., additional, Neuman, Manuela, additional, Ng'wanasayi, Masolwa, additional, Ni, Yan, additional, Nicoll, Amanda, additional, Niizeki, Takashi, additional, Nikolova, Dafina, additional, Ningning, Wang, additional, Niriella, Madunil, additional, Nogoibaeva, K.A, additional, Nordien, Rozeena, additional, O Sullivan, Catherine, additional, O'Beirne, James, additional, Obekpa, Solomon, additional, Ocama, Ponsiano, additional, Ochwoto, Missiani, additional, Ogolodom, Michael Promise, additional, Ojo, Olusegun, additional, Okrostsvaridze, Nana, additional, Oliveira, Claudia P., additional, Omaña, Raul Contreras, additional, Omar, Omneya M., additional, Omar, Hanaa, additional, Omar, Mabroka, additional, Omran, Salma, additional, Omran, Reham, additional, Osman, Marian Muse, additional, Owise, Nevin, additional, Owusu-Ansah, Theobald, additional, Padilla- Machaca, P. Martín, additional, Palle, Sirish, additional, Pan, Ziyan, additional, Pan, Xiao-Yan, additional, Pan, Qiuwei, additional, Papaefthymiou, Apostolis, additional, Paquissi, Feliciano Chanana, additional, Par, Gabriella, additional, Parkash, Arit, additional, Payawal, Diana, additional, Peltekian, Kevork M., additional, Peng, Xuebin, additional, Peng, Liang, additional, Peng, Ying, additional, Pengoria, Rahul, additional, Perez, Martina, additional, Pérez, José Luis, additional, Pérez, Norma Marlene, additional, Persico, Marcello, additional, Pessoa, Mário Guimarães, additional, Petta, Salvatore, additional, Philip, Mathew, additional, Plaz Torres, Maria Corina, additional, Polavarapu, Naveen, additional, Poniachik, Jaime, additional, Portincasa, Piero, additional, Pu, Chunwen, additional, Pürnak, Tuğrul, additional, Purwanto, Edhie, additional, Qi, Xiaolong, additional, Qi, Xingshun, additional, Qian, Zibing, additional, Qiang, Zhao, additional, Qiao, Zengpei, additional, Qiao, Liang, additional, Queiroz, Alberto, additional, Rabiee, Atoosa, additional, Radwan, Manal, additional, Rahetilahy, Alain Marcel, additional, Ramadan, Yasmin, additional, Ramadan, Dina, additional, Ramli, Anis Safura, additional, Ramm, Grant A., additional, Ran, Ao, additional, Rankovic, Ivan, additional, RAO, Huiying, additional, Raouf, Sara, additional, Ray, Sayantan, additional, Reau, Nancy, additional, Refaat, Ahmed, additional, Reiberger, Thomas, additional, Remes-Troche, Jose M, additional, Reyes, Eira Cerda, additional, Richardson, Ben, additional, Ridruejo, Ezequiel, additional, Riestra Jimenez, Sergio, additional, Rizk, Ibrahim, additional, Roberts, Stuart, additional, Roblero, Juan Pablo, additional, Robles, Jorge Alberto Prado, additional, Rockey, Don, additional, Rodríguez, Manuel, additional, Rodríguez Hernández, Heriberto, additional, Román, Eva, additional, Romeiro, Fernando Gomes, additional, Romeo, Stefano, additional, Rosales-Zabal, Jose Miguel, additional, Roshdi, Georgina R., additional, Rosso, Natalia, additional, Ruf, Andres, additional, Ruiz, Patricia Cordero, additional, Runes, Nelia R., additional, Ruzzenente, Andrea, additional, Ryan, Marno, additional, Saad, Ahmed, additional, Sabbagh, Eman BE, additional, Sabbah, Meriam, additional, Saber, Shimaa, additional, Sabrey, Reham, additional, Sabry, Ramy, additional, Saeed, Maysaa Abdallah, additional, Said, Dina, additional, Said, Ebada M, additional, Sakr, Mohammad Amin, additional, Salah, Yara, additional, Salama, Rabab Maamoun, additional, Salama, Asmaa, additional, Saleh, Hussein, additional, Saleh, Ahmed, additional, Salem, Ahmed, additional, Salem, Ahmed Thabet, additional, Salifou, Alkassoum, additional, Salih, Aso Faeq, additional, Salman, Abdallah, additional, Samouda, Hanen, additional, Sanai, Faisal, additional, Sánchez-Ávila, Juan Francisco, additional, Sanker, Lakshumanan, additional, Sano, Tomoya, additional, Sanz, Miquel, additional, Saparbu, Tobokalova, additional, Sawhney, Rohit, 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Sigurdardottir, Solveig, additional, Sira, Mostafa Mohamed, additional, Siradj, Riyadh, additional, Sison, Cecilia, additional, Smyth, Linda, additional, Soliman, Reham, additional, Sollano, Jose D, additional, Sombie, Roger, additional, Sonderup, Mark, additional, Sood, Siddharth, additional, Soriano, German, additional, Stedman, Catherine A M, additional, Stefanyuk, Oksana, additional, Štimac, Davor, additional, Strasser, Simone, additional, Strnad, Pavel, additional, Stuart, Katherine, additional, Su, Wen, additional, Su, Minghua, additional, Sumida, Yoshio, additional, Sumie, Shuji, additional, Sun, Dan-Qin, additional, Sun, Jing, additional, Suzuki, Hiroyuki, additional, Svegliati-Baroni, Gianluca, additional, Swar, Mohamed Osman, additional, TAHARBOUCHT, S., additional, Taher, Zenab, additional, Takamura, Saori, additional, Tan, Lin, additional, Tan, Soek-Siam, additional, Tanwandee, Tawesak, additional, Tarek, Sara, additional, Tatiana, Ghelimici, additional, Tavaglione, Federica, additional, Tecson, Gina Y., additional, Tee, Hoi-Poh, additional, Teschke, Rolf, additional, Tharwat, Mostafa, additional, Thong, Vo Duy, additional, Thursz, Mark, additional, Tine, Tulari, additional, Tiribelli, Claudio, additional, Tolmane, Ieva, additional, Tong, Jing, additional, Tongo, Marco, additional, Torkie, Mamdouh, additional, Torre, Aldo, additional, Torres, Esther A, additional, Trajkovska, Meri, additional, Treeprasertsuk, Sombat, additional, Tsutsumi, Tsubasa, additional, Tu, Thomas, additional, Tur, Josep A., additional, Turan, Dilara, additional, Turcan, Svetlana, additional, Turkina, Svetlana, additional, Tutar, Engin, additional, Tzeuton, Christian, additional, Ugiagbe, Rose, additional, Uygun, Ahmet, additional, Vacca, Michele, additional, Vajro, Pietro, additional, Van der Poorten, David, additional, Van Kleef, Laurens A., additional, Vashakidze, Eliza, additional, Velazquez, Carlos Moctezuma, additional, Velazquez, Mirtha Infante, additional, Vento, 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Jing-Hang, additional, Xu, Keshu, additional, Xu, Yumin, additional, Xu, Shi-Hao, additional, Xu, Meng, additional, Xu, Aimin, additional, Xu, Chengfu, additional, Yan, Hongmei, additional, Yang, Jingyi, additional, Yang, Rui-Xu, additional, Yang, Yating, additional, Yang, Qinhe, additional, Yang, Naibin, additional, Yao, Jia, additional, Yara, Justine, additional, Yaraş, Serkan, additional, Yılmaz, Nimet, additional, Younes, Ramy, additional, younes, Huda, additional, Young, Sona, additional, Youssef, Farah, additional, Yu, Yanyan, additional, Yu, Ming-Lung, additional, Yuan, Jing, additional, Yue, Zhang, additional, Yuen, Man-Fung, additional, Yun, Wang, additional, Yurukova, Nonka, additional, Zakaria, Serag, additional, Zaky, Samy, additional, Zaldastanishvili, Maia, additional, Zapata, Rodrigo, additional, Zare, Nazanin, additional, Zerem, Enver, additional, Zeriban, Nema, additional, Zeshuai, Xu, additional, Zhang, Huijie, additional, Zhang, Xuemei, additional, Zhang, Yupei, additional, Zhang, Wen-Hua, additional, Zhang, Xuchen, additional, Zhang, Yon-ping, additional, Zhang, Yuexin, additional, Zhang, Zhan-qing, additional, Zhao, Jingmin, additional, Zhao, Rong-Rong, additional, Zhao, Hongwei, additional, Zheng, Chao, additional, Zheng, Yijie, additional, Zheng, Ruidan, additional, Zheng, Tian-Lei, additional, Zheng, Kenneth, additional, Zhou, Xi Qiao, additional, Zhou, Yongjian, additional, Zhou, Yu-Jie, additional, Zhou, Hong, additional, Zhou, Ling, additional, Zhou, Yongning, additional, Zhu, Long dong, additional, Zhu, Yong Fen, additional, Zhu, Yueyong, additional, Zhu, Pei-Wu, additional, Ziada, Ebtesam, additional, Ziring, David, additional, Ziyi, Li, additional, Zou, Shanshan, additional, Zou, Zhengsheng, additional, Zou, Huaibin, additional, and Zuart Ruiz, Roberto, additional

Published
2022
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38. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Author

Johnson, Katherine, Leary, Peter J., Govaere, Olivier, Barter, Matthew J., Charlton, Sarah H., Cockell, Simon J., Tiniakos, Dina, Zatorska, Michalina, Bedossa, Pierre, Brosnan, M. Julia, Cobbold, Jeremy F., Ekstedt, Mattias, Aithal, Guruprasad P., Boursier, Jerome, Ratziu, Vlad, Bugianesi, Elisabetta, Anstee, Quentin M., Daly, Ann K., Clark, James, Cockell, Simon, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, McGlinchey, Aidan, Sen, Partho, Mato, Jose, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla, Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, and Twiss, James

Subjects
Hepatology, Gastroenterology, Internal Medicine, Immunology and Allergy, digestive system diseases
Abstract

Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 serum miRNAs in a discovery cohort (183 cases with NAFLD representing the complete NAFLD spectrum and 10 population controls). miRNA libraries generated by HTG EdgeSeq were sequenced by Illumina NextSeq. Selected serum miRNAs were profiled in 372 additional cases with NAFLD and 15 population controls by quantitative reverse transcriptase PCR. Results: Levels of 275 miRNAs differed between cases and population controls. Fewer differences were seen within individual NAFLD stages, but miR-193a-5p consistently showed increased levels in all comparisons. Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2–4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5–8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2–4 compared with lower SAF activity. The significant findings for miR-193a-5p were replicated in the additional cohort with NAFLD. Studies in Hep G2 cells showed that following palmitic acid treatment, miR-193a-5p expression decreased significantly. Gene targets for miR-193a-5p were investigated in liver RNAseq data for a case subgroup (n = 80); liver GPX8 levels correlated positively with serum miR-193a-5p. Conclusions: Serum miR-193a-5p levels correlate strongly with NAFLD activity grade and fibrosis stage. MiR-193a-5p may have a role in the hepatic response to oxidative stress and is a potential clinically tractable circulating biomarker for progressive NAFLD. Lay summary: MicroRNAs (miRNAs) are small pieces of nucleic acid that may turn expression of genes on or off. These molecules can be detected in the blood circulation, and their levels in blood may change in liver disease including non-alcoholic fatty liver disease (NAFLD). To see if we could detect specific miRNA associated with advanced stages of NAFLD, we carried out miRNA sequencing in a group of 183 patients with NAFLD of varying severity together with 10 population controls. We found that a number of miRNAs showed changes, mainly increases, in serum levels but that 1 particular miRNA miR-193a-5p consistently increased. We confirmed this increase in a second group of cases with NAFLD. Measuring this miRNA in a blood sample may be a useful way to determine whether a patient has advanced NAFLD without an invasive liver biopsy.

Published
2022

39. Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Author

Mózes, Ferenc E, Lee, Jenny A, Vali, Yasaman, Alzoubi, Osama, Staufer, Katharina, Trauner, Michael, Paternostro, Rafael, Stauber, Rudolf E, Holleboom, Adriaan G, van Dijk, Anne-Marieke, Mak, Anne Linde, Boursier, Jérôme, de Saint Loup, Marc, Shima, Toshihide, Bugianesi, Elisabetta, Gaia, Silvia, Armandi, Angelo, Shalimar, Lupșor-Platon, Monica, Wong, Vincent Wai-Sun, Li, Guanlin, Wong, Grace Lai-Hung, Cobbold, Jeremy, Karlas, Thomas, Wiegand, Johannes, Sebastiani, Giada, Tsochatzis, Emmanuel, Liguori, Antonio, Yoneda, Masato, Nakajima, Atsushi, Hagström, Hannes, Akbari, Camilla, Hirooka, Masashi, Chan, Wah-Kheong, Mahadeva, Sanjiv, Rajaram, Ruveena, Zheng, Ming-Hua, George, Jacob, Eslam, Mohammed, Petta, Salvatore, Pennisi, Grazia, Viganò, Mauro, Ridolfo, Sofia, Aithal, Guruprasad Padur, Palaniyappan, Naaventhan, Lee, Dae Ho, Ekstedt, Mattias, Nasr, Patrik, Cassinotto, Christophe, de Lédinghen, Victor, Berzigotti, Annalisa, Mendoza, Yuly P, Noureddin, Mazen, Truong, Emily, Fournier-Poizat, Céline, Geier, Andreas, Martic, Miljen, Tuthill, Theresa, Anstee, Quentin M, Harrison, Stephen A, Bossuyt, Patrick M, Pavlides, Michael, Anstee, Quentin M, Daly, Ann K, Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J, Day, Christopher P, Wonders, Kristy, Missier, Paolo, McTeer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M, Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G, Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M, Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K, Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioannis, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J, Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, McGlinchey, Aiden, Mato, Jose M, Millet, Óscar, Dufour, Jean-François, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Rasmussen, Daniel Guldager Kring, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattias, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M P, Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andreas, Trautwein, Christian, Reißing, Johanna, Aithal, Guruprasad P, Francis, Susan, Palaniyappan, Naaventhan, Bradley, Christopher, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W, Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, McLeod, Euan James, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Coxson, Harvey, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Kjær, Mette Skalshøi, Harder, Lea Mørch, Davidsen, Peter, Ellegaard, Jens, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Douglas, Shankar, Sudha, Torstenson, Richard, Lindén, Daniel, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D, Billin, Andrew, Doward, Lynda, Twiss, James, Thakker, Paresh, Derdak, Zoltan, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, and Hytiroglou, Prodromos

Abstract

Histologically assessed liver fibrosis stage has prognostic significance in patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate endpoint in clinical trials for non-cirrhotic NAFLD. Our aim was to compare the prognostic performance of non-invasive tests with liver histology in patients with NAFLD.

Published
2023
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40. Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Author

Younes, Ramy Caviglia, Gian Paolo Younes, Ramy Caviglia, Gian Paolo Govaere, Olivier Rosso, Chiara Armandi, Angelo and Sanavia, Tiziana Pennisi, Grazia Liguori, Antonio and Francione, Paolo Gallego-Duran, Rocio Ampuero, Javier and Blanco, Maria J. Garcia Aller, Rocio Tiniakos, Dina Burt, Alastair David, Ezio Vecchio, Fabio M. Maggioni, Marco and Cabibi, Daniela Pareja, Maria Jesus Zaki, Marco Y. W. and Grieco, Antonio Fracanzani, Anna L. Valenti, Luca Miele, Luca Fariselli, Piero Petta, Salvatore Romero-Gomez, Manuel and Anstee, Quentin M. Bugianesi, Elisabetta

Abstract

Background & Aims: Non-invasive scoring systems (NSS) are used to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their reliability in predicting long-term outcomes for hepatic/extrahepatic complications or death and their concordance in cross-sectional and longitudinal risk stratification remain uncertain. Methods: The most common NSS (NFS, FIB-4, BARD, APRI) and the Hepamet fibrosis score (HFS) were assessed in 1,173 European patients with NAFLD from tertiary centres. Performance for fibrosis risk stratification and for the prediction of long-term hepatic/extrahepatic events, hepatocarcinoma (HCC) and overall mortality were evaluated in terms of AUC and Harrell’s c-index. For longitudinal data, NSS-based Cox proportional hazard models were trained on the whole cohort with repeated 5-fold cross-validation, sampling for testing from the 607 patients with all NSS available. Results: Cross-sectional analysis revealed HFS as the best performer for the identification of significant (F0-1 vs. F2-4, AUC = 0.758) and advanced (F0-2 vs. F3-4, AUC = 0.805) fibrosis, while NFS and FIB-4 showed the best performance for detecting histological cirrhosis (range AUCs 0.85-0.88). Considering longitudinal data (follow-up between 62 and 110 months), NFS and FIB-4 were the best at predicting liver-related events (c-indices>0.7), NFS for HCC (c-index = 0.9 on average), and FIB-4 and HFS for overall mortality (c-indices >0.8). All NSS showed limited performance (c-indices

Published
2021

41. Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?

Author

Zaki, Marco Y.W., primary, Alhasan, Sari F., additional, Shukla, Ruchi, additional, McCain, Misti, additional, Laszczewska, Maja, additional, Geh, Daniel, additional, Patman, Gillian L., additional, Televantou, Despina, additional, Whitehead, Anna, additional, Maurício, João P., additional, Barksby, Ben, additional, Gee, Lucy M., additional, Paish, Hannah L., additional, Leslie, Jack, additional, Younes, Ramy, additional, Burt, Alastair D., additional, Borthwick, Lee A., additional, Thomas, Huw, additional, Beale, Gary S., additional, Govaere, Olivier, additional, Sia, Daniela, additional, Anstee, Quentin M., additional, Tiniakos, Dina, additional, Oakley, Fiona, additional, and Reeves, Helen L., additional

Published
2022
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42. Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

Author

Fouad, Yasser, primary, Palmer, Melissa, additional, Chen, Minjun, additional, Regev, Arie, additional, Banerjee, Rajarshi, additional, Myers, Rob, additional, Riccio, Robert, additional, Torstenson, Richard, additional, Younes, Ramy, additional, Arora, Puneet S., additional, Landgren, Henrik, additional, Karsdal, Morten A., additional, Blake, Martin, additional, Shapiro, David A., additional, Gruss, Hans-Juergen, additional, Sheikh, Muhammad Y., additional, Attia, Dina, additional, Bollipo, Steven, additional, Smith, Alastair D., additional, Freilich, Bradley, additional, Gish, Robert G., additional, and Schuppan, Detlef, additional

Published
2021
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43. Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Author

Younes, Ramy, primary, Caviglia, Gian Paolo, additional, Govaere, Olivier, additional, Rosso, Chiara, additional, Armandi, Angelo, additional, Sanavia, Tiziana, additional, Pennisi, Grazia, additional, Liguori, Antonio, additional, Francione, Paolo, additional, Gallego-Durán, Rocío, additional, Ampuero, Javier, additional, Garcia Blanco, Maria J., additional, Aller, Rocio, additional, Tiniakos, Dina, additional, Burt, Alastair, additional, David, Ezio, additional, Vecchio, Fabio M., additional, Maggioni, Marco, additional, Cabibi, Daniela, additional, Pareja, María Jesús, additional, Zaki, Marco Y.W., additional, Grieco, Antonio, additional, Fracanzani, Anna L., additional, Valenti, Luca, additional, Miele, Luca, additional, Fariselli, Piero, additional, Petta, Salvatore, additional, Romero-Gomez, Manuel, additional, Anstee, Quentin M., additional, and Bugianesi, Elisabetta, additional

Published
2021
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44. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Author

Selvaraj, Emmanuel Anandraj, primary, Mózes, Ferenc Emil, additional, Jayaswal, Arjun Narayan Ajmer, additional, Zafarmand, Mohammad Hadi, additional, Vali, Yasaman, additional, Lee, Jenny A., additional, Levick, Christina Kim, additional, Young, Liam Arnold Joseph, additional, Palaniyappan, Naaventhan, additional, Liu, Chang-Hai, additional, Aithal, Guruprasad Padur, additional, Romero-Gómez, Manuel, additional, Brosnan, M. Julia, additional, Tuthill, Theresa A., additional, Anstee, Quentin M., additional, Neubauer, Stefan, additional, Harrison, Stephen A., additional, Bossuyt, Patrick M., additional, Pavlides, Michael, additional, Anstee, Quentin, additional, Daly, Ann, additional, Johnson, Katherine, additional, Govaere, Olivier, additional, Cockell, Simon, additional, Tiniakos, Dina, additional, Bedossa, Pierre, additional, Oakley, Fiona, additional, Cordell, Heather, additional, Day, Chris, additional, Wonders, Kristy, additional, Bossuyt, Patrick, additional, Zafarmand, Hadi, additional, Lee, Jenny, additional, Ratziu, Vlad, additional, Clement, Karine, additional, Pais, Raluca, additional, Schuppan, Detlef, additional, Schattenberg, Jörn, additional, Vidal-Puig, Toni, additional, Vacca, Michele, additional, Rodrigues-Cuenca, Sergio, additional, Allison, Mike, additional, Kamzolas, Ioannis, additional, Petsalaki, Evangelia, additional, Oresic, Matej, additional, Hyötyläinen, Tuulia, additional, McGlinchey, Aiden, additional, Mato, Jose M., additional, Millet, Oscar, additional, Dufour, Jean-François, additional, Berzigotti, Annalisa, additional, Harrison, Stephen, additional, Cobbold, Jeremy, additional, Mozes, Ferenc, additional, Akhtar, Salma, additional, Banerjee, Rajarshi, additional, Kelly, Matt, additional, Shumbayawonda, Elizabeth, additional, Dennis, Andrea, additional, Erpicum, Charlotte, additional, Gómez-González, Emilio, additional, Ampuero, Javier, additional, Castell, Javier, additional, Gallego-Durán, Rocío, additional, Fernández, Isabel, additional, Montero-Vallejo, Rocío, additional, Karsdal, Morten, additional, Erhardtsen, Elisabeth, additional, Rasmussen, Daniel, additional, Leeming, Diana Julie, additional, Fisker, Mette Juul, additional, Sinisi, Antonia, additional, Musa, Kishwar, additional, Betsou, Fay, additional, Sandt, Estelle, additional, Tonini, Manuela, additional, Bugianesi, Elisabetta, additional, Rosso, Chiara, additional, Armandi, Angelo, additional, Marra, Fabio, additional, Gastaldelli, Amalia, additional, Svegliati, Gianluca, additional, Boursier, Jérôme, additional, Francque, Sven, additional, Vonghia, Luisa, additional, Ekstedt, Mattias, additional, Kechagias, Stergios, additional, Yki-Jarvinen, Hannele, additional, Luukkonen, Panu, additional, van Mil, Saskia, additional, Papatheodoridis, George, additional, Cortez-Pinto, Helena, additional, Valenti, Luca, additional, Petta, Salvatore, additional, Miele, Luca, additional, Geier, Andreas, additional, Trautwein, Christian, additional, Aithal, Guru, additional, Hockings, Paul, additional, Newsome, Philip, additional, Wenn, David, additional, Pereira Rodrigues, Cecília Maria, additional, Chaumat, Pierre, additional, Hanf, Rémy, additional, Trylesinski, Aldo, additional, Ortiz, Pablo, additional, Duffin, Kevin, additional, Brosnan, Julia, additional, Tuthill, Theresa, additional, McLeod, Euan, additional, Ertle, Judith, additional, Younes, Ramy, additional, Ostroff, Rachel, additional, Alexander, Leigh, additional, Kjær, Mette Skalshøi, additional, Mikkelsen, Lars Friis, additional, Balp, Maria-Magdalena, additional, Brass, Clifford, additional, Jennings, Lori, additional, Martic, Miljen, additional, Loeffler, Juergen, additional, Hanauer, Guido, additional, Shankar, Sudha, additional, Fournier, Céline, additional, Pepin, Kay, additional, Ehman, Richard, additional, Myers, Joel, additional, Ho, Gideon, additional, Torstenson, Richard, additional, Myers, Rob, additional, and Doward, Lynda, additional

Published
2021
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45. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Author

Lee, Jenny A., Selvaraj, Emmanuel A., Jayaswal, Arjun N.A., Trauner, Michael, Staufer, Katharina, Stauber, Rudolf E., Bugianesi, Elisabet-ta, Younes, Ramy, Gaia, Silvia, Lup?or-Platon, Monica, Petta, Salvatore, Shima, Toshihide, Okanoue, Takeshi, Mahadeva, Sanjiv, Chan, Wah-Kheong, Eddowes, Peter J., Newsome, Philip N., Wai-Sun Wong, Vincent, Fan, Jian-Gao, Shen, Feng, Cobbold, Jeremy F., Sumida, Yoshio, Okajima, Akira, Labenz, Christian, Kim, Won, Lee, Myoung Seok, Wiegand, Johannes, Karlas, Thomas, Yilmaz, Yusuf, Aithal, Guruprasad Padur, Palaniyappan, Naaventhan, Cassinotto, Christophe, Aggarwal, Sandeep, Garg, Harshit, Ooi, Geraldine, Nakajima, Atsushi, Yoneda, Masato, Ziol, Marianne, Barget, Nathalie, Geier, Andreas, Tuthill, Theresa, Brosnan, Julia M., Anstee, Quentin M., Neubauer, Stefan, Harrison, Stephen A., Bossuyt, Patrick M., and Pavlides, Michael

Subjects
Gastroenterology
Abstract

Objective: Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM- VCTE), Fibrosis-4 index (FIB-4) and NAFLD Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies.Design: Individual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individu-ally and in sequential combinations.Results: Data were included from 37 primary studies (n=5735; 45% female; median age: 54 years; median BMI: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (

Published
2021

46. enDiagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Author

Mózes, Ferenc Emil, Lee, Jenny A, Selvaraj, Emmanuel Anandraj, Jayaswal, Arjun Narayan Ajmer, Trauner, Michael, Boursier, Jerome, Fournier, Céline, Staufer, Katharina, Stauber, Rudolf E, Bugianesi, Elisabetta, Younes, Ramy, Gaia, Silvia, Lupșor-Platon, Monica, Petta, Salvatore, Shima, Toshihide, Okanoue, Takeshi, Mahadeva, Sanjiv, Chan, Wah-Kheong, Eddowes, Peter J, Hirschfield, Gideon M, Newsome, Philip Noel, Wong, Vincent Wai-Sun, de Ledinghen, Victor, Fan, Jiangao, Shen, Feng, Cobbold, Jeremy F, Sumida, Yoshio, Okajima, Akira, Schattenberg, Jörn M, Labenz, Christian, Kim, Won, Lee, Myoung Seok, Wiegand, Johannes, Karlas, Thomas, Yılmaz, Yusuf, Aithal, Guruprasad Padur, Palaniyappan, Naaventhan, Cassinotto, Christophe, Aggarwal, Sandeep, Garg, Harshit, Ooi, Geraldine J, Nakajima, Atsushi, Yoneda, Masato, Ziol, Marianne, Barget, Nathalie, Geier, Andreas, Tuthill, Theresa, Brosnan, M Julia, Anstee, Quentin Mark, Neubauer, Stefan, Harrison, Stephen A, Bossuyt, Patrick M, and Pavlides, Michael

Subjects
610 Medicine & health
Abstract

OBJECTIVE Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies. DESIGN Individual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individually and in sequential combinations. RESULTS Data were included from 37 primary studies (n=5735; 45% women; median age: 54 years; median body mass index: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (

Published
2021
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47. Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver Disease

Author

Fonds de Recherche du Québec, McGill University, Petta, Salvatore, Sebastiani, Giada, Viganò, Mauro, Ampuero, Javier, Wai-Sun Wong, Vincent, Boursier, Jerome, Berzigotti, Annalisa, Bugianesi, Elisabetta, Fracanzani, Anna Ludovica, Cammà, Calogero, Enea, Marco, des Grottes, Marraud, Di Marco, Vito, Younes, Ramy, Keyrouz, Aline, Mazzola, Sergio, Mendoza, Yuly, Pennisi, Grazia, Romero-Gómez, Manuel, Craxi, Antonio, de Ledinghen, Victor, Fonds de Recherche du Québec, McGill University, Petta, Salvatore, Sebastiani, Giada, Viganò, Mauro, Ampuero, Javier, Wai-Sun Wong, Vincent, Boursier, Jerome, Berzigotti, Annalisa, Bugianesi, Elisabetta, Fracanzani, Anna Ludovica, Cammà, Calogero, Enea, Marco, des Grottes, Marraud, Di Marco, Vito, Younes, Ramy, Keyrouz, Aline, Mazzola, Sergio, Mendoza, Yuly, Pennisi, Grazia, Romero-Gómez, Manuel, Craxi, Antonio, and de Ledinghen, Victor

Abstract

[Background & Aims] Patients with advanced fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at risk of developing hepatic and extrahepatic complications. We investigated whether, in a large cohort of patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements (LSMs) and their changes can be used to identify patients at risk for liver-related and extrahepatic events., [Methods] We performed a retrospective analysis of consecutive patients with NAFLD (n = 1039) with a histologic diagnosis of F3–F4 fibrosis and/or LSMs>10 kPa, followed for at least 6 months, from medical centers in 6 countries. LSMs were made by FibroScan using the M or XL probe and recorded at baseline and within 1 year from the last follow-up examination. Differences between follow up and baseline LSMs were categorized as: improvement (reduction of more than 20%), stable (reduction of 20% to an increase of 20%), impairment (an increase of 20% or more). We recorded hepatic events (such as liver decompensation, ascites, encephalopathy, variceal bleeding, jaundice, or hepatocellular carcinoma [HCC]) and overall and liver-related mortality during a median follow-up time of 35 months (interquartile range, 19–63 months)., [Results] Based on Cox regression analysis, baseline LSM was independently associated with occurrence of hepatic decompensation (hazard ratio [HR], 1.03; 95% CI, 1.02–1.04; P < .001), HCC (HR, 1.03; 95% CI, 1.00–1.04; P = .003), and liver-related death (HR, 1.02; 95% CI, 1.02–1.03; P = .005). In 533 patients with available LSMs during the follow-up period, change in LSM was independently associated with hepatic decompensation (HR, 1.56; 95% CI, 1.05–2.51; P = .04), HCC (HR, 1.72; 95% CI, 1.01–3.02; P = .04), overall mortality (HR, 1.73; 95% CI, 1.11–2.69; P = .01), and liver-related mortality (HR, 1.96; 95% CI, 1.10–3.38; P = .02)., [Conclusions] In patients with NAFLD and compensated advanced chronic liver disease, baseline LSM and change in LSM are associated with risk of liver-related events and mortality.

Published
2021

48. Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Author

Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, Tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, Garcia Blanco, Maria J, Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesú, Zaki, Marco Y W, Grieco, Antonio, Fracanzani, Anna L, Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gomez, Manuel, Anstee, Quentin M, Bugianesi, Elisabetta, Vecchio, Fabio M (ORCID:0000-0002-9197-2264), Grieco, Antonio (ORCID:0000-0002-0544-8993), Miele, Luca (ORCID:0000-0003-3464-0068), Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, Tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, Garcia Blanco, Maria J, Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesú, Zaki, Marco Y W, Grieco, Antonio, Fracanzani, Anna L, Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gomez, Manuel, Anstee, Quentin M, Bugianesi, Elisabetta, Vecchio, Fabio M (ORCID:0000-0002-9197-2264), Grieco, Antonio (ORCID:0000-0002-0544-8993), and Miele, Luca (ORCID:0000-0003-3464-0068)

Abstract

Background & Aims: Non-invasive scoring systems (NSS) are used to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their reliability in predicting long-term outcomes for hepatic/extrahepatic complications or death and their concordance in cross-sectional and longitudinal risk stratification remain uncertain.Methods: The most common NSS (NFS, FIB-4, BARD, APRI) and the Hepamet fibrosis score (HFS) were assessed in 1,173 European patients with NAFLD from tertiary centres. Performance for fibrosis risk stratification and for the prediction of long-term hepatic/extrahepatic events, hepatocarcinoma (HCC) and overall mortality were evaluated in terms of AUC and Harrell's c-index. For longitudinal data, NSS-based Cox proportional hazard models were trained on the whole cohort with repeated 5-fold cross-validation, sampling for testing from the 607 patients with all NSS available.Results: Cross-sectional analysis revealed HFS as the best performer for the identification of significant (F0-1 vs. F2-4, AUC = 0.758) and advanced (F0-2 vs. F3-4, AUC = 0.805) fibrosis, while NFS and FIB-4 showed the best performance for detecting histological cirrhosis (range AUCs 0.85-0.88). Considering longitudinal data (follow-up between 62 and 110 months), NFS and FIB-4 were the best at predicting liver-related events (c-indices>0.7), NFS for HCC (c-index = 0.9 on average), and FIB-4 and HFS for overall mortality (c-indices >0.8). All NSS showed limited performance (c-indices <0.7) for extrahepatic events.Conclusions: Overall, NFS, HFS and FIB-4 outperformed APRI and BARD for both cross-sectional identification of fibrosis and prediction of long-term outcomes, confirming that they are useful tools for the clinical management of patients with NAFLD at increased risk of fibrosis and liver-related complications or death.Lay summary: Non-invasive scoring systems are increasingly being used in patients with non-alcoholic fatty

Published
2021

49. Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Author

European Commission, Newcastle Biomedical Research Centre, Ministero della Salute, Ministero dell'Istruzione, dell'Università e della Ricerca, Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, García Blanco, María J., Aller, Rocío, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesús, Zaki, Marco Y. W., Grieco, Antonio, Fracanzani, Anna Ludovica, Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gómez, Manuel, Anstee, Quentin M., Bugianesi, Elisabetta, European Commission, Newcastle Biomedical Research Centre, Ministero della Salute, Ministero dell'Istruzione, dell'Università e della Ricerca, Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, García Blanco, María J., Aller, Rocío, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesús, Zaki, Marco Y. W., Grieco, Antonio, Fracanzani, Anna Ludovica, Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gómez, Manuel, Anstee, Quentin M., and Bugianesi, Elisabetta

Abstract

[Background & Aims] Non-invasive scoring systems (NSS) are used to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their reliability in predicting long-term outcomes for hepatic/extrahepatic complications or death and their concordance in cross-sectional and longitudinal risk stratification remain uncertain., [Methods] The most common NSS (NFS, FIB-4, BARD, APRI) and the Hepamet fibrosis score (HFS) were assessed in 1,173 European patients with NAFLD from tertiary centres. Performance for fibrosis risk stratification and for the prediction of long-term hepatic/extrahepatic events, hepatocarcinoma (HCC) and overall mortality were evaluated in terms of AUC and Harrell’s c-index. For longitudinal data, NSS-based Cox proportional hazard models were trained on the whole cohort with repeated 5-fold cross-validation, sampling for testing from the 607 patients with all NSS available., [Results] Cross-sectional analysis revealed HFS as the best performer for the identification of significant (F0-1 vs. F2-4, AUC = 0.758) and advanced (F0-2 vs. F3-4, AUC = 0.805) fibrosis, while NFS and FIB-4 showed the best performance for detecting histological cirrhosis (range AUCs 0.85-0.88). Considering longitudinal data (follow-up between 62 and 110 months), NFS and FIB-4 were the best at predicting liver-related events (c-indices>0.7), NFS for HCC (c-index = 0.9 on average), and FIB-4 and HFS for overall mortality (c-indices >0.8). All NSS showed limited performance (c-indices <0.7) for extrahepatic events., [Conclusions] Overall, NFS, HFS and FIB-4 outperformed APRI and BARD for both cross-sectional identification of fibrosis and prediction of long-term outcomes, confirming that they are useful tools for the clinical management of patients with NAFLD at increased risk of fibrosis and liver-related complications or death., [Lay summary] Non-invasive scoring systems are increasingly being used in patients with non-alcoholic fatty liver disease to identify those at risk of advanced fibrosis and hence clinical complications. Herein, we compared various non-invasive scoring systems and identified those that were best at identifying risk, as well as those that were best for the prediction of long-term outcomes, such as liver-related events, liver cancer and death.

Published
2021

50. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Author

Mózes, Ferenc Emil, primary, Lee, Jenny A, additional, Selvaraj, Emmanuel Anandraj, additional, Jayaswal, Arjun Narayan Ajmer, additional, Trauner, Michael, additional, Boursier, Jerome, additional, Fournier, Céline, additional, Staufer, Katharina, additional, Stauber, Rudolf E, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Gaia, Silvia, additional, Lupșor-Platon, Monica, additional, Petta, Salvatore, additional, Shima, Toshihide, additional, Okanoue, Takeshi, additional, Mahadeva, Sanjiv, additional, Chan, Wah-Kheong, additional, Eddowes, Peter J, additional, Hirschfield, Gideon M, additional, Newsome, Philip Noel, additional, Wong, Vincent Wai-Sun, additional, de Ledinghen, Victor, additional, Fan, Jiangao, additional, Shen, Feng, additional, Cobbold, Jeremy F, additional, Sumida, Yoshio, additional, Okajima, Akira, additional, Schattenberg, Jörn M, additional, Labenz, Christian, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Wiegand, Johannes, additional, Karlas, Thomas, additional, Yılmaz, Yusuf, additional, Aithal, Guruprasad Padur, additional, Palaniyappan, Naaventhan, additional, Cassinotto, Christophe, additional, Aggarwal, Sandeep, additional, Garg, Harshit, additional, Ooi, Geraldine J, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Ziol, Marianne, additional, Barget, Nathalie, additional, Geier, Andreas, additional, Tuthill, Theresa, additional, Brosnan, M. Julia, additional, Anstee, Quentin Mark, additional, Neubauer, Stefan, additional, Harrison, Stephen A., additional, Bossuyt, Patrick M, additional, and Pavlides, Michael, additional

Published
2021
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