1. Scirrhous colonic metastasis from lobular carcinoma of breast
- Author
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Kazumoto Murata, Tsuyoshi Ishida, Naomi Uemura, Sumio Watanabe, Masashi Mizokami, Naru Chatani, Masaaki Korenaga, Hitohiko Koizuka, Naohiko Masaki, Tatsuya Kanto, Yoichiro Aoki, Yoshihiko Aoki, Masatoshi Imamura, Tsutomu Takeda, and Tomoyuki Yada
- Subjects
Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Lobular carcinoma ,Gastroenterology ,Transverse colon ,General Medicine ,medicine.disease ,Hematochezia ,Breast cancer ,Bone scintigraphy ,Invasive lobular carcinoma ,Biopsy ,medicine ,medicine.symptom ,Differential diagnosis ,business - Abstract
A 68-year-old woman presented complaining of 2 months vague abdominal fullness and constipation. She had a history of surgery 5 years ago for invasive lobular carcinoma of the left breast. She had good appetite without any severe symptoms such as vomiting, diarrhea, or hematochezia. No abnormal subcutaneous lymph nodes were detected, and blood tests showed no abnormalities including serum tumor markers. Whole-body computed tomography and bone scintigraphy revealed no tumor recurrences. However, endoscopic findings demonstrated a smooth stenotic lesion with submucosal thickening in the transverse colon, but the colonic mucous membrane was grossly normal. The 3-cm-long stenotic lesion was confirmed by colon imaging using water-soluble contrast medium. A biopsy specimen revealed diffuse infiltration of noncohesive malignant cells with round, atypical nuclei from lamina propria to subserosa. Taken together with immunohistochemistry, a diagnosis of metastatic lobular carcinoma from the breast was made, and transverse segmentectomy was done. Colonic metastasis of breast cancer should be included as a differential diagnosis of any abdominal symptoms, even though mild, when patients have a present or previous history of breast cancer.
- Published
- 2013