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Tumorigenicity study of butyl and isobutyl p-hydroxybenzoates administered orally to mice
- Source :
- Food and Chemical Toxicology. 23:575-578
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- Butyl p-hydroxybenzoate (n-BHB) and isobutyl p-hydroxybenzoate (i-BHB) were administered orally to ICR/Jcl mice at concentrations of 0.6 (maximum tolerated dose), 0.3 or 0.15% in the diet for up to 102 wk. Tumours were observed at various sites including the haematopoietic system, the lung and the soft tissue. However, at none of the sites did the tumour incidence or the time to death with tumours differ significantly from that in the untreated control group.
- Subjects :
- Male
Ratón
Administration, Oral
Parabens
Pharmacology
Toxicology
Mice
Oral administration
Animals
Hydroxybenzoates
Carcinogen
Antibacterial agent
Mice, Inbred ICR
Leukemia, Experimental
Dose-Response Relationship, Drug
Mutagenicity Tests
Chemistry
Amyloidosis
Neoplasms, Experimental
General Medicine
Haematopoiesis
Dose–response relationship
Biochemistry
Toxicity
Food Preservatives
Female
Food Science
Subjects
Details
- ISSN :
- 02786915
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....5deef8adbdb67cc243fbd6720374a78f