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Objective:To systematically review the effect of narrative nursing for cancer patients. Methods:Systematic searches in PubMed, EMBASE, The Cochrane Library, Web of Science, Chinese biomedical literature database, China National Knowledge Infrastructure, Wanfang medical and VIP database were performed for randomized controlled trials (RCTs) or quasi-RCTs which explored the effects of narrative nursing mode for cancer patients. Then, meta-analysis was performed by RevMan 5.3 after two independent investigators screened the literature, extracted the data and evaluated the risk of bias of all included studies. Results:A total of 15 studies were included, including 1778 cancer patients. The meta-analysis showed that narrative nursing could effectively relieve patients' anxiety and depression compared with the conventional nursing model (WMD = -9.04, 95% CI = -11.82, -6.27; P < 0.001), reduce the the inner shame (WMD = -2.28, 95% CI = -3.76, -0.88; P = 0.001), improved the mental resilience (WMD = 18.20, 95% CI = 3.30, 33.11; P < 0.001) and the quality of life. Conclusion:This study has been systematically evaluated to show that narrative care can effectively improve the negative mood of patients with cancer and improve their quality of life. However, subject to the quality limitations of the included studies, the appeal conclusions are yet to be tested in more high-quality studies.

The present study aimed to give a short report on a possible mechanism of glycyrrhizin to acetaminophen-induced liver toxicity. Seven-day intraperitoneal administration of glycyrrhizin (400 mg/kg/day) to 2- to 3-month-old male C57BL/6N mice (mean weight 27 g) significantly prevents acetaminophen-induced liver damage, as indicated by the activity of alanine transaminase and aspartate aminotransferase. Metabolomics analysis and principal component analysis (PCA) using ultra-fast liquid chromatography coupled to triple time-of-flight mass spectrometer were performed. PCA separated well the control, glycyrrhizin-treated, acetaminophen-treated, and glycyrrhizin+acetaminophen-treated groups. Long-chain acylcarnitines were listed as the top ions that contribute to this good separation, which include oleoylcarnitine, palmitoylcarnitine, palmitoleoylcarnitine, and myristoylcarnitine. The treatment of glycyrrhizin significantly reversed the increased levels of long-chain acylcarnitines induced by acetaminophen administration. In conclusion, this metabolomic study indicates a significant glycyrrhizin protection effect against acetaminophen-induced liver damage through reversing fatty acid metabolism.

The present study aimed to give a short report on a possible mechanism of glycyrrhizin to acetaminophen-induced liver toxicity. Seven-day intraperitoneal administration of glycyrrhizin (400 mg/kg/day) to 2- to 3-month-old male C57BL/6N mice (mean weight 27 g) significantly prevents acetaminophen-induced liver damage, as indicated by the activity of alanine transaminase and aspartate aminotransferase. Metabolomics analysis and principal component analysis (PCA) using ultra-fast liquid chromatography coupled to triple time-of-flight mass spectrometer were performed. PCA separated well the control, glycyrrhizin-treated, acetaminophen-treated, and glycyrrhizin+acetaminophen-treated groups. Long-chain acylcarnitines were listed as the top ions that contribute to this good separation, which include oleoylcarnitine, palmitoylcarnitine, palmitoleoylcarnitine, and myristoylcarnitine. The treatment of glycyrrhizin significantly reversed the increased levels of long-chain acylcarnitines induced by acetaminophen administration. In conclusion, this metabolomic study indicates a significant glycyrrhizin protection effect against acetaminophen-induced liver damage through reversing fatty acid metabolism.

To investigate the effects of substance P on cultured rat osteoclasts.Neurokinin-1 (NK1) receptor expression in osteoclasts was examined by immunohitochemical method, and changes of bone resorption activity caused by substance P and NK1 receptor antagonists were detected by pit formation assay.Immunoreactivity for NK1 receptor was distributed in the cytoplasm of osteoclasts. The average of pit formation areas significantly increased with addition of substance P (10(-7)-10(-4) mol/L) (P0.05), but the number of pitformations did not change (P0.05). NK1 receptor antagonists inhibited the enhancement of the bone resorption by substance P addition.The findings suggested that substance P may stimulate osteoclasts and result in bone resorption by the mediation of NK1 receptor.

To evaluate the outcome of the treatment of malocclusion with mandibular congenital missing teeth guided by Bolton index.26 class I and II cases (males 10, females 16) were chosen in this study. Guided by Bolton index, enamel stripping, denture and two types of tooth extraction were used in the treatment.Normal Bolton index was achieved and the results of treatment were satisfactory.Malocclusion with mandibular congenital missing teeth can be treated successfully guided by Bolton index.