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[Substance P regulates function of osteoclasts via neurokinin-1 receptor]
- Source :
- Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. 24(1)
- Publication Year :
- 2006
-
Abstract
- To investigate the effects of substance P on cultured rat osteoclasts.Neurokinin-1 (NK1) receptor expression in osteoclasts was examined by immunohitochemical method, and changes of bone resorption activity caused by substance P and NK1 receptor antagonists were detected by pit formation assay.Immunoreactivity for NK1 receptor was distributed in the cytoplasm of osteoclasts. The average of pit formation areas significantly increased with addition of substance P (10(-7)-10(-4) mol/L) (P0.05), but the number of pitformations did not change (P0.05). NK1 receptor antagonists inhibited the enhancement of the bone resorption by substance P addition.The findings suggested that substance P may stimulate osteoclasts and result in bone resorption by the mediation of NK1 receptor.
- Subjects :
- Animals
Osteoclasts
Receptors, Neurokinin-1
Substance P
Rats
Subjects
Details
- ISSN :
- 10001182
- Volume :
- 24
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
- Accession number :
- edsair.pmid..........f433b771a28e7538f969e78ba512c149