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Defects, which arise during the growth and processing of the wood, affect the visual and mechanical properties. To improve the utilization of wood with defects, we propose an image inpainting method that reconstructs the texture at defects. The result of image inpainting is visually very consistent with the surrounding healthy board. According to the result, as an application, the plate that is most similar to the surrounding texture could be matched to fill the missing position due to the removal of defects. First, the image inpainting is divided into two stages: coarse inpainting and detailed inpainting. The coarse generator quickly generates the prediction result of the missing area, and the result is fed to the detailed generator to produce a more refined image. Then, the skip connection is applied to the classical Encoder–Decoder in order to solve the problem of information loss due to upsampling. Next, the attention block is introduced in the detailed generator to pay more attention to the meaningful semantics. Finally, normalizing missing and known regions together would result in a bias in the mean and standard deviation, so Partition Normalization was used instead of Batch Normalization. The feature map is divided into two parts, foreground and background, and the two parts are normalized separately. The experimental results show that the results of image inpainting are still high precision with less time spent on the training network. Code, demo and models are available at: https://github.com/NEFUJoeyChen/TG-Net .

Potassium-ion batteries (PIBs) are promising next-generation energy storage candidates due to abundant resources and low cost. Sb-based materials with high theoretical capacity (660 mAh·g−1) and low working potential are considered as promising anode for PIBs. The remaining challenge is poor stability and slow kinetics. In this work, FeSb@N-doped carbon quantum dots anchored in three-dimensional (3D) porous N-doped carbon (FeSb@C/N⊂3DC/N), a Sb-based material with a particular structure, is designed and constructed by a green salt-template method. As an anode for PIBs, it exhibits extraordinarily high-rate and long-cycle stability (a capacity of 245 mAh·g−1 at 3,080 mA·g−1 after 1,000 cycles). The pseudocapacitance contribution (83%) is demonstrated as the origin of high-rate performance of the FeSb@C/N⊂3DC/N electrode. Furthermore, the potassium storage mechanism in the electrode is systematically investigated through ex-situ characterization techniques including ex-situ transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). Overall, this study could provide a useful guidance for future design of high-performance electrode materials for PIBs.

Background The JACOB trial (NCT01774786) was a double-blinded, placebo-controlled, randomized, multicenter, international, phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemotherapy in first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer (GEJC). The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial. Methods This post hoc subpopulation analysis included all patients recruited in mainland China (n = 163; 20.9%) between June 2013 and January 2016. The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy (pertuzumab group; n = 82) or placebo plus trastuzumab and chemotherapy (control group; n = 81). Intravenous pertuzumab (840 mg) and trastuzumab (8 mg/kg loading and 6 mg/kg maintenance doses) were given every 3 weeks until disease progression or unacceptable toxicity. Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin. The primary endpoint was overall survival (OS); secondary efficacy endpoints included progression-free survival (PFS), and overall objective response rate (ORR). Results The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group (hazard ratio [HR] 0.75; 95% confidence interval [CI] 0.49 to 1.14). The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups, respectively (HR 0.85; 95% CI 0.60 to 1.21), and the median ORRs were 68.9% and 55.7%, respectively. The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group. The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable. The most common grade 3–5 adverse events were neutropenia, anemia, and leukopenia. However, due to the nature of being a post hoc subgroup analysis, the results presented here are descriptive only and need to be interpreted with caution. Conclusions OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients, and this regimen demonstrated an acceptable safety profile. Trial registration ClinicalTrials.gov. NCT01774786. Registered on 24 January 2013, https://clinicaltrials.gov/ct2/show/NCT01774786 Electronic supplementary material The online version of this article (10.1186/s40880-019-0384-6) contains supplementary material, which is available to authorized users.

The Chinese healthcare industry has immense potential for innovation and requires competent publication professionals for global reach. Changes in regulatory landscape of China necessitates pharmaceutical industries to collaborate with medical professionals who are capable of keeping up with both changes in regulations and innovative medicine. We initiated an online questionnaire-based survey via WeChat from August 3 to August 14, 2019 which focused on experience level, challenges, career development, and training requirements of survey participants. A total of 53 medical publication professionals participated in this survey. Contrary to global trends, 77% of participants had

In TiO2 both advantages (stability and low cost) and disadvantages (large bandgap) coexist, so how to optimize a bare TiO2 electrode is a continuous hot topic for the construction of suitable photoelectrochemical (PEC) devices based on TiO2 for water splitting. This paper reports a facile and simple fabrication of a TiO2/RGO/C3N4 photoelectrode for PEC splitting of water. Its heterostructure configuration has been characterized and confirmed by XRD, Raman spectroscopy, XPS, TEM and STEM. The introduction of both RGO and C3N4 film onto the surface of TiO2 is mainly due to the fact that C3N4 has a strong photoelectric ability to respond to visible light and RGO plays an important role in the fast transfer of photogenerated charges across interfaces. Photocurrent and monochromatic incident photon-to-photocurrent efficiency (IPCE) of the titled heterostructure have been obviously improved, and the IPCE value (0.5 V vs. AgCl/Ag) of TiO2/RGO/C3N4 was estimated to be up to 28% at a wavelength of 400 nm.

This paper presents a facile one-step approach for the syntheses of MoS2/GC (GC = graphitic carbon) with sodium alginate as the biomass carbon source. The MoS2/GC composites showed enhanced photocatalytic activity for degradation of methylene blue under visible light irradiation. The MoS2/GC (2 : 1) composite shows the best performance and 99.2% methylene blue can be removed in 100 minutes. GC plays an important role in the fast separation and transfer of photogenerated charges across interfaces. The activity and stability performances suggest that the MoS2/GC composite has great potential for practical industrial wastewater treatment.

This paper presents for the first time a novel method of depositing plasmonic Bi nanoparticles on BiOCl nanosheets (Bi/BiOCl) via insitu photoelectroreduction, and Bi/BiOCl as the photocathode enabled solar water splitting in a TiO2–Bi/BiOCl photoelectrochemical (PEC) system. It is one of the challenges to understand the relationship between the PEC performance and the composite ratio of Bi/BiOCl, and the density functional theory calculation results show that charges obviously transfer from the Bi cluster to the BiOCl (001) surface. The structure of Bi/BiOCl photocathode has been successfully optimized, according to the current–potential curves and charge injection efficiency. The highly enhanced PEC activity could be attributed to the dual roles of Bi nanoparticles in enhancing the charge transfer and surface plasmon resonance (SPR) effect. More importantly, the optimal Bi/BiOCl photocathode achieved a solar hydrogen evolution rate of 2.4 µmol h−1 under full spectrum illumination (100 mW cm−2).

Additional file 1: Table S1. Post-study anti-cancer therapies used by at least 2 patients (ITT population).

This study reports a novel Au@CdS/RGO/TiO2 heterostructure as a photoelectrode for photoelectrochemical (PEC) hydrogen generation via water splitting. The unique heterostructures of the Au@CdS/RGO/TiO2 photoelectrode were confirmed by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). Au@CdS nanoparticles with a core–shell structure were introduced into the TiO2 photoelectrode for the first time, and the Au@CdS nanoparticles could endow the TiO2 photoelectrode with both visible light response ability and the plasmonic property. Moreover, the RGO thin film sandwiched between TiO2 nanorod and Au@CdS core–shell nanoparticles played an important role in the fast transport of photogenerated charges, due to its excellent electrical conductivity. Clear enhancements of photocurrent and monochromatic incident photon-to-photocurrent efficiency were observed, resulting from the synergistic effect between Au@CdS core–shell nanoparticles and the RGO thin film. More importantly, Au@CdS/RGO/TiO2 photoelectrode achieved a considerable hydrogen evolution rate (4.821 mmol h−1 m−2) under full spectrum illumination (47 mW cm−2).

MoS2, a kind of two-dimensional material with unique performances, has been widely used in many fields. However, an in-depth understanding of its toxicity is still needed, let alone its effects on the environmental microorganism. Herein, we used different methods, including metabolomics technology, to investigate the influence of bulk MoS2 (BMS) on yeast cells. The results indicated that high concentrations (1 mg/L and more) of BMS could destroy cell membrane and induce ROS accumulation. When exposed to a low concentration of BMS (0.1 mg/L), the intracellular concentrations of many metabolites (e.g., fumaric acid, lysine) increased. However, most of their concentrations descended significantly as the yeast cells were treated with BMS of high concentrations (1 mg/L and more). Metabolomics analysis further revealed that exposure to high concentrations of BMS could significantly affect some metabolic pathways such as amino acid and citrate cycle related metabolism. These findings will be beneficial for MoS2 toxicity assessment and further applications.

International audience; MoS2, a kind of two-dimensional material with unique performances, has been widely used in many fields. However, an in-depth understanding of its toxicity is still needed, let alone its effects on the environmental microorganism. Herein, we used different methods, including metabolomics technology, to investigate the influence of bulk MoS2 (BMS) on yeast cells. The results indicated that high concentrations (1 mg/L and more) of BMS could destroy cell membrane and induce ROS accumulation. When exposed to a low concentration of BMS (0.1 mg/L), the intracellular concentrations of many metabolites (e.g., fumaric acid, lysine) increased. However, most of their concentrations descended significantly as the yeast cells were treated with BMS of high concentrations (1 mg/L and more). Metabolomics analysis further revealed that exposure to high concentrations of BMS could significantly affect some metabolic pathways such as amino acid and citrate cycle related metabolism. These findings will be beneficial for MoS2 toxicity assessment and further applications.

A novel one-dimensional MgFe2O4/MoS2 heterostructure has been successfully designed and fabricated. The bare MgFe2O4 was obtained as uniform nanowires through electrospinning, and MoS2 thin film appeared on the surface of MgFe2O4 after further chemical vapor deposition. The structure of the MgFe2O4/MoS2 heterostructure was systematic investigated by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectrometry (XPS), and Raman spectra. According to electrochemical impedance spectroscopy (EIS) results, the MgFe2O4/MoS2 heterostructure showed a lower charge-transfer resistance compared with bare MgFe2O4, which indicated that the MoS2 played an important role in the enhancement of electron/hole mobility. MgFe2O4/MoS2 heterostructure can efficiently degrade tetracycline (TC), since the superoxide free-radical can be produced by sample under illumination due to the active species trapping and electron spin resonance (ESR) measurement, and the optimal photoelectrochemical degradation rate of TC can be achieved up to 92% (radiation intensity: 47 mW/cm(2), 2 h). Taking account of its unique semiconductor band gap structure, MgFe2O4/MoS2 can also be used as an photoelectrochemical anode for hydrogen production by water splitting, and the hydrogen production rate of MgFe2O4/MoS2 was 5.8 mmol/h·m(2) (radiation intensity: 47 mW/cm(2)), which is about 1.7 times that of MgFe2O4.

The Ni-MOF as co-catalyst has been in-situ introduced on the surface of ZnO photoelectrode by chemical etching method for the first time, and the unique organic/inorganic heterostructure (Ni-MOF/ZnO) was applied for photoelectrochemical water splitting. The Ni-MOF could work as special co-catalyst to improve the kinetic and charges separation of ZnO electrode, and the photocurrent density of Ni-MOF/ZnO has increased to about 1.8 times than that of bare ZnO. The IPCE value of Ni-MOF/ZnO has been enhanced up to 11% (355[Formula: see text]nm, 0.5[Formula: see text]V vs Ag/AgCl). The proposed mechanism of charges transfer has been also discussed in-depth, according to the photoelectrochemical performance.

In this work, we successfully fabricated a novel stable photoanode, which was built from ZnO nanosheets in situ decorated with carbon film (ZnO/carbon). The thin carbon film, as a passivation layer, can not only improve the photoelectrochemical (PEC) performance, but also significantly depress the photocorrosion of ZnO. Compared with bare ZnO photoanode, the photocurrent density of ZnO/carbon has been increased nearly five times, and its IPCE value can be up to 27% (0.5[Formula: see text]V versus Ag/AgCl). Moreover, the XRD, SEM and TEM data further demonstrate the crystal and microscopic structure of ZnO/carbon in detail.

To investigate the efficacy of intratympanic dexamethasone injection (IDI) for 23 patients with intractable sudden sensorineural hearing loss (SSNHL).Dexamethasone (5 g/ml) was injected into the middle ear. The injection was repeated once two days and had a total of 4 doses (10 mg).The 23 patients were followed up for one month. Eight of 23 patients (34.8%) demonstrated a 17 to approximately 54 dB improvement in PTA and 15 of 23 (65.2%) had no response.IDI is a simple and effective treatment for SSNHL patient who had not responded to conventional therapy, although hearing was rarely improved to normal levels.