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Effect of bulk MoS2 on the metabolic profile of yeast
- Source :
- Journal of Nanoscience and Nanotechnology, Journal of Nanoscience and Nanotechnology, American Scientific Publishers, 2018, 18 (6), pp.3901-3907. ⟨10.1166/jnn.2018.15015⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; MoS2, a kind of two-dimensional material with unique performances, has been widely used in many fields. However, an in-depth understanding of its toxicity is still needed, let alone its effects on the environmental microorganism. Herein, we used different methods, including metabolomics technology, to investigate the influence of bulk MoS2 (BMS) on yeast cells. The results indicated that high concentrations (1 mg/L and more) of BMS could destroy cell membrane and induce ROS accumulation. When exposed to a low concentration of BMS (0.1 mg/L), the intracellular concentrations of many metabolites (e.g., fumaric acid, lysine) increased. However, most of their concentrations descended significantly as the yeast cells were treated with BMS of high concentrations (1 mg/L and more). Metabolomics analysis further revealed that exposure to high concentrations of BMS could significantly affect some metabolic pathways such as amino acid and citrate cycle related metabolism. These findings will be beneficial for MoS2 toxicity assessment and further applications.
- Subjects :
- Fumaric acid
Materials science
[SDV]Life Sciences [q-bio]
Lysine
Biomedical Engineering
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Two-Dimensional Material
chemistry.chemical_compound
[SDV.IDA]Life Sciences [q-bio]/Food engineering
Metabolome
Metabolomics
General Materials Science
[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
chemistry.chemical_classification
General Chemistry
Metabolism
021001 nanoscience & nanotechnology
Condensed Matter Physics
Yeast
0104 chemical sciences
Amino acid
Metabolic pathway
chemistry
Biochemistry
Microbial Toxicity
Toxicity
0210 nano-technology
MoS2
Subjects
Details
- Language :
- English
- ISSN :
- 15334880
- Database :
- OpenAIRE
- Journal :
- Journal of Nanoscience and Nanotechnology, Journal of Nanoscience and Nanotechnology, American Scientific Publishers, 2018, 18 (6), pp.3901-3907. ⟨10.1166/jnn.2018.15015⟩
- Accession number :
- edsair.doi.dedup.....fd0878e9a938956a18775b176a5e149d