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Beckwith-Wiedemann syndrome (BWS) is a growth disorder in which BWS is associated with aberrant expression of genes imprinted in the critical region of BWS and is considered a clinical spectrum in which affected individuals may have many or only one or two typical clinical features. Postnatal neonatal screening is particularly important to facilitate early diagnosis and treatment of this disorder. In this paper, we report a case of a neonate with a large tongue as the first symptom, hypoglycemia during hospitalization, and umbilical hernia in the late follow-up, and genetic testing results suggesting that he carried a c.235T>C (p.Trp79Arg) variant as a missense variant in the coding region of the cyclin dependent kinase inhibitor 1C (CDKN1C) gene, and that a T→C transition in nucleotides at position 235 of the CDKN1C gene, i.e., a missense mutation in the amino acid located in amino acid 79. This resulted in the mutation of tryptophan to arginine. Combining the clinical features of the child with the genetic test results, the diagnosis of BWS was confirmed. The purpose of this case report and the related genetic research progress is to improve the understanding of the clinical diagnosis and treatment of BWS, and to avoid misdiagnosis and under-diagnosis.

Objective To investigate the effect of Chinese herbal medicine hot pack therapy combined with meibomian gland massage on relieving uncomfortable symptoms of patients with dry eye of liver-kidney Yin deficiency. Methods Totally 100 patients with dry eye of Liver-kidney Yin deficiency were randomly divided into the study group and control group, with 50 cases in each group. All patients received routine treatment and nursing, and those in the study group were given three course of Chinese herbal medicine hot pack therapy combined with meibomian gland massage. Results The overall effective rate in the study group was higher than that in the control group (98. 00% vs. 70. 00%, P

ObjectiveTo explore the role of supportive psychotherapy in mental health improvement of COVID-19 positive patients， and to provide references for the implementation of early psychological intervention measures in response to the sudden epidemic outburst， such as COVID-19.MethodsA total of 35 patients with severe COVID-19 admitted to ICU ward of Wuhan People’s Hospital from February 1 to March 1， 2020 were enrolled in this study. All the selected individuals received a 2-week supportive psychotherapy. Then Pittsburgh Sleep Quality Index （PSQI）， Patients’ Health Questionnaire Depression Scale-9 item （PHQ-9）， Generalized Anxiety Disorder Scale （GAD-7） and Social Support Rating Scale （SSRS） were used to evaluate the sleep quality， depression， anxiety and social support of participants at the baseline and the 2nd week of the intervention.ResultsInsomnia was detected in 32 patients （91.43%）， anxiety symptoms in 31 （88.57%）， depressive symptoms in 32 （91.43%）， and 29 patients （82.86%） reported feeling a lack of social support. After 2 weeks of intervention， the PSQI， GAD-7 and PHQ-9 scores decreased （t=5.272， 5.475， 4.621， P

Gas chromatography-ion mobility spectrometry (GC-IMS) was performed to investigate the changes of volatile organic compounds (VOCs) in fried green tea with different packaging during storage. The results showed that a total of 86 VOCs were detected by GC-IMS, of which 59 VOCs were identified, including 28 aldehydes, 7 ketones, 9 alcohols, 9 esters, 4 heterocyclic compounds, 1 acids and 1 sulfur. With the extension of storage time, the content of fried green tea VOCs decreased. More importantly, the VOCs of green tea were more stable in packaging of aluminum with deoxidizer than packaging of aluminum. And the content of (E, E)-2,4-heptadienal and heptanal with clean and refreshing, benzaldehyde and phenylacetaldehyde with chestnut, nonanal and 6-methyl-5-hepten-2-one with flowery, 2-hep-tanone with cheese flavor and etc were higher in packaging of aluminum with deoxidizer. These study supply a theoretical basis for the flavor quality control of fried green tea during storage. The two-dimensional spectrogram showed that VOCs of fried green tea with different packaging during storage could be well separated. The GC-IMS fingerprints of fried green tea with different packaging were preliminarily established, which provided a novel idea for the rapid evaluation of the fried green tea quality during storage. [ABSTRACT FROM AUTHOR]