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1. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression

Author

Halaschek-Wiener, Julius, Brooks-Wilson, Angela R., Khattra, Jaswinder S., Marra, Marco A., Riddle, Donald L., McKay, Sheldon, Jones, Steven J.M., Pouzyrev, Anatoli, Holt, Robert A., Stott, Jeff M., and Yang, Geroge S.

Subjects
Gene expression -- Research, Messenger RNA -- Research, Caenorhabditis elegans -- Genetic aspects, Genetic research, Health
Abstract

Longevity-associated genes are identified in a long-lived Caenorhabditis elegans daf-2 mutant using serial analysis of gene expression (SAGE), a method that efficiently quantifies large numbers of mRNA transcripts by sequencing short tags. Global analysis of metabolis-associated genes resulted hypometabolic features in mid-life daf-2 mutants that diminish with advanced age.

Published
2005

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