Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression

Longevity-associated genes are identified in a long-lived Caenorhabditis elegans daf-2 mutant using serial analysis of gene expression (SAGE), a method that efficiently quantifies large numbers of mRNA transcripts by sequencing short tags. Global analysis of metabolis-associated genes resulted hypometabolic features in mid-life daf-2 mutants that diminish with advanced age.