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13,986 results on '"Yang, Gao"'

1. DCF-DS: Deep Cascade Fusion of Diarization and Separation for Speech Recognition under Realistic Single-Channel Conditions

Author

Niu, Shu-Tong, Du, Jun, Wang, Ruo-Yu, Yang, Gao-Bin, Gao, Tian, Pan, Jia, and Hu, Yu

Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing, Computer Science - Sound
Abstract

We propose a single-channel Deep Cascade Fusion of Diarization and Separation (DCF-DS) framework for back-end speech recognition, combining neural speaker diarization (NSD) and speech separation (SS). First, we sequentially integrate the NSD and SS modules within a joint training framework, enabling the separation module to leverage speaker time boundaries from the diarization module effectively. Then, to complement DCF-DS training, we introduce a window-level decoding scheme that allows the DCF-DS framework to handle the sparse data convergence instability (SDCI) problem. We also explore using an NSD system trained on real datasets to provide more accurate speaker boundaries during decoding. Additionally, we incorporate an optional multi-input multi-output speech enhancement module (MIMO-SE) within the DCF-DS framework, which offers further performance gains. Finally, we enhance diarization results by re-clustering DCF-DS outputs, improving ASR accuracy. By incorporating the DCF-DS method, we achieved first place in the realistic single-channel track of the CHiME-8 NOTSOFAR-1 challenge. We also perform the evaluation on the open LibriCSS dataset, achieving a new state-of-the-art performance on single-channel speech recognition.

Published
2024

2. Emotional and Cognitive Dissonance of Teachers of Japanese as a Foreign Language towards Technology-Mediated Language Teaching Curriculum: A 'Perezhivanie Perspective'

Author

Lili Qin, Xibei Ouyang, Yang Gao, and Mairin Hennebry-Leung

Abstract

In new paradigms, teachers' cognition and emotion must be considered dialectically shaped co-evolving processes. To address the issue, the study examined how language teachers' "perezhivaniya" (plural form of "perezhivanie," a concept from Sociocultural Theory that describes a unity between cognition and emotion) developed. During a semester (17 weeks), a study of 13 teachers of Japanese as a foreign language was conducted at a university in northeast China. Narrative inquiry was used to collect perezhivaniya excerpts from retrospective diaries, reflection diaries, and interviews. Q-methodology was also employed to group participants based on their cognitive and emotional changes toward technology-mediated language teaching (TMLT). In our study, teachers' negative perezhivaniya resulted from a lack of affordances for online and hybrid education in professional development. Teachers experienced many dramas (unit of analysis of perezhivaniya) as they adapted to TMLT. Conversely, teachers' positive perezhivaniya originated from teacher agency and developed through affordances offered by the sociocultural community. We also found teacher perezhivaniya changed in three staged patterns: resistance and demotivation (during large-scale offline teaching before the pandemic), obligation and adaptation (during large-scale online teaching during the pandemic), and inventiveness and motivation (during online and offline blended teaching after the pandemic). In conclusion, we identified teachers' perezhivaniya developed in a dynamic, historical, complex as well as multi-layered (with time-developmental, drama-historical, and SSD-social as indicators) pattern.

Published
2024
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4. Periodic Implicit Representation, Design and Optimization of Porous Structures Using Periodic B-splines

Author

Depeng, Gao, Yang, Gao, and Hongwei, Lin

Subjects
Computer Science - Graphics
Abstract

Porous structures are intricate solid materials with numerous small pores, extensively used in fields like medicine, chemical engineering, and aerospace. However, the design of such structures using computer-aided tools is a time-consuming and tedious process.In this study, we propose a novel representation method and design approach for porous units that can be infinitely spliced to form a porous structure. We use periodic B-spline functions to represent periodic or symmetric porous units. Starting from a voxel representation of a porous sample, the discrete distance field is computed. To fit the discrete distance field with a periodic B-spline, we introduce the constrained least squares progressive-iterative approximation algorithm, which results in an implicit porous unit. This unit can be subject to optimization to enhance connectivity and utilized for topology optimization, thereby improving the model's stiffness while maintaining periodicity or symmetry. The experimental results demonstrate the potential of the designed complex porous units in enhancing the mechanical performance of the model. Consequently, this study has the potential to incorporate remarkable structures derived from artificial design or nature into the design of high-performing models, showing the promise for biomimetic applications., Comment: 38 pages, 12 figures

Published
2024

8. Search for the radiative decay D s + → γρ 770 + $$ {D}_s^{+}\to \gamma \rho {(770)}^{+} $$

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, X. Y. Chai, J. F. Chang, G. R. Che, Y. Z. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, L. Ge, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, J. J. Lane, L. Lavezzi, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, K. L. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, L. R. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. M. Ma, F. E. Maas, I. MacKay, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, X. K. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, M. Q. Ruan, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, S. S Su, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. Xu, Y. C. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, J. H. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Junhao Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, M. C. Yu, T. Yu, X. D. Yu, Y. C. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, N Zhang, P. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. M. Zhang, X. Y Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, Z. Z. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, Z. C. Zhou, A. N. Zhu, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, T. J. Zhu, W. D. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
Branching fraction, Charm Physics, e +-e − Experiments, Rare Decay, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Using 7.33 fb −1 of e + e − collision data samples collected with the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, we search for the radiative decay D s + → γρ 770 + $$ {D}_s^{+}\to \gamma \rho {(770)}^{+} $$ for the first time. A hint of D s + → γρ 770 + $$ {D}_s^{+}\to \gamma \rho {(770)}^{+} $$ is observed with a statistical significance of 2.5σ. The branching fraction of D s + → γρ 770 + $$ {D}_s^{+}\to \gamma \rho {(770)}^{+} $$ is measured to be (2.2 ± 0.9stat. ± 0.2syst. ) × 10 −4, corresponding to an upper limit of 6.1 × 10 −4 at the 90% confidence level.

Published
2024
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9. Comparison of the content of active ingredients and antioxidant, antibacterial and anti-inflammatory activities in different parts of Fructus Choerospondiatis

Author

Yuchao Zhao, Chunfeng Xia, Chengkun Jiang, Chaonan Kan, Yang Gao, Yiping Zou, and Liren He

Subjects
Total flavonoids, Fructus Choerospondiatis, Antioxidation, Bacteriostatic, Anti-inflammatory, Medicine, Science
Abstract

Abstract Fructus Choerospondiatis (FC) has been utilized in Mongolian medicine for the treatment of many diseases. This investigation assessed the coloration, five active components, total phenolic and flavonol contents, as well as the antioxidant and antibacterial properties of different parts of FC from eight cultivars, and the optimal cultivar was identified to determine the anti-inflammatory capacity of all parts. The findings revealed that L* and b* values of the dried peel powder were the highest and the a* value of whole fruit powder was the highest. The concentrations of gallic acid, catechin, epicatechin, total phenols, and total flavonoids exhibited a positive correlation with antioxidant activity. A comprehensive analysis revealed that the peel contained a greater abundance of active compounds and exhibited stronger antioxidant and antibacterial properties compared to other parts. RPNO.1 can be used as the source of high-quality FC for clinical application. In vivo anti-inflammatory experiments indicated that both the flesh and peel of RPNO.1 displayed the highest anti-inflammatory effect. This research not only addressed the gap in studies regarding FC’ s anti-inflammatory properties but also proved that the peel of FC, which was often discarded, had utilization value and could be used as a medicinal herb.

Published
2024
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10. Measurement of Born cross sections of e + e − → Ξ 0 Ξ ¯ 0 $$ {e}^{+}{e}^{-}\to {\Xi}^0{\overline{\Xi}}^0 $$ and search for charmonium(-like) states at s $$ \sqrt{s} $$ = 3.51–4.95 GeV

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, X. Y. Chai, J. F. Chang, G. R. Che, Y. Z. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, L. Ge, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, Q. P. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, L. Lavezzi, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, K. L. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, C. X. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, Liang Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, L. R. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. M. Ma, F. E. Maas, I. MacKay, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, X. K. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, M. Q. Ruan, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, S. S Su, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. H. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. Xu, Y. C. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, J. H. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Junhao Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, M. C. Yu, T. Yu, X. D. Yu, Y. C. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. M. Zhang, X. Y Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, Z. Z. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, Z. C. Zhou, A. N. Zhu, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, T. J. Zhu, W. D. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
e +-e − Experiments, Particle and Resonance Production, QCD, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Using e + e − collision data collected by the BESIII detector at BEPCII corresponding to an integrated luminosity of 30 fb −1, we measure Born cross sections and effective form factors for the process e + e − → Ξ 0 Ξ ¯ 0 $$ {e}^{+}{e}^{-}\to {\Xi}^0{\overline{\Xi}}^0 $$ at forty-five center-of-mass energies between 3.51 and 4.95 GeV. The dressed cross section is fitted, assuming a power-law function plus a charmonium(-like) state, i.e., ψ(3770), ψ(4040), ψ(4160), ψ(4230), ψ(4360), ψ(4415) or ψ(4660). No significant charmonium(-like) state decaying into Ξ 0 Ξ ¯ 0 $$ {\Xi}^0{\overline{\Xi}}^0 $$ is observed. Upper limits at the 90% confidence level on the product of the branching fraction and the electronic partial width are provided for each decay. In addition, ratios of the Born cross sections and the effective form factors for e + e − → Ξ 0 Ξ ¯ 0 $$ {e}^{+}{e}^{-}\to {\Xi}^0{\overline{\Xi}}^0 $$ and e + e − → Ξ − Ξ ¯ + $$ {e}^{+}{e}^{-}\to {\Xi}^{-}{\overline{\Xi}}^{+} $$ are also presented to test isospin symmetry and the vector meson dominance model.

Published
2024
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11. Ancestral Sequence Reconstruction Enhances Thermal Stability of D-Allulose 3-Epimerase

Author

Lijun GUAN, Ling ZHU, Kunlun WANG, Jialei LI, Yang GAO, Song YAN, Xindi ZHANG, Qing CHEN, Nina JI, and Bo LI

Subjects
ancestral sequence reconstruction, d-allulose, d-allulose 3-epimerase, thermostability, Food processing and manufacture, TP368-456
Abstract

To solve the problem of poor thermal stability of the current D-allulose 3-epimerase (DAEase), the ancestor sequences of DAEase with different catalytic domains were reconstructed by big data mining, reasonable modification and ancestor sequence reconstruction (ASR) strategy under the guidance of phylogenetic information. The expression vectors of the ancestor sequences were constructed, and DAEase A13 with significantly enhanced thermal stability was screened by recombinant expression and molecular docking, and its enzymatic properties were characterized. In addition, the molecular mechanism of thermal stability enhancement of DAEase A13 was revealed based on structural analysis and molecular dynamics. The results showed that the half-life of A13 constructed based on ASR strategy could reach 8.4 h at 70 ℃, indicating that its thermal stability was significantly enhanced compared with that of wild-type (WT) enzyme. The maximum conversion rate of A13 reached 31%, indicating that the catalytic activity of A13 was slightly higher than that of WT enzyme. The structural and molecular dynamics analysis revealed that the increase in hydrogen bonding and hydrophobic interaction in ASR A13 was the main factor responsible for maintaining the stability of the enzyme's molecular structure at high temperatures. The results showed that ASR strategy could modify DAEases to enhance the stability, activity or hybridity, which could provide superior biocatalyst sources for various industrial applications of functional sugars.

Published
2024
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12. Analysis of the dynamics of the decay D + → K S 0 π 0 e + ν e $$ {D}^{+}\to {K}_S^0{\pi}^0{e}^{+}{\nu}_e $$

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, X. Y. Chai, J. F. Chang, G. R. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, L. Ge, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, J. J. Lane, L. Lavezzi, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, K. L. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, L. R. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. M. Ma, F. E. Maas, I. MacKay, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, X. K. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, S. S Su, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. Xu, Y. C. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Junhao Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, M. C. Yu, T. Yu, X. D. Yu, Y. C. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. M. Zhang, X. Y Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, Z. Z. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, Z. C. Zhou, A. N. Zhu, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, T. J. Zhu, W. D. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
Branching fraction, Charm Physics, e +-e − Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The branching fraction of D + → K S 0 π 0 e + ν e $$ {D}^{+}\to {K}_S^0{\pi}^0{e}^{+}{\nu}_e $$ is measured for the first time using 7.93 fb −1 of e + e − annihilation data collected at the center-of-mass energy s $$ \sqrt{s} $$ = 3.773 GeV with the BESIII detector operating at the BEPCII collider, and is determined to be B D + → K S 0 π 0 e + ν e = 0.881 ± 0.017 stat . ± 0.016 syst . % $$ \mathcal{B}\left({D}^{+}\to {K}_S^0{\pi}^0{e}^{+}{\nu}_e\right)=\left(0.881\pm {0.017}_{\textrm{stat}.}\pm {0.016}_{\textrm{syst}.}\right)\% $$ . Based on an analysis of the D + → K S 0 π 0 e + ν e $$ {D}^{+}\to {K}_S^0{\pi}^0{e}^{+}{\nu}_e $$ decay dynamics, we observe the S-wave and P-wave components with fractions of f S-wave = (6.13 ± 0.27stat. ± 0.30syst. )% and f K ¯ ∗ 892 0 = 93.88 ± 0.27 stat . ± 0.29 syst . % $$ {f}_{{\overline{K}}^{\ast }{(892)}^0}=\left(93.88\pm {0.27}_{\textrm{stat}.}\pm {0.29}_{\textrm{syst}.}\right)\% $$ , respectively. From these results, we obtain the branching fractions B D + → K S 0 π 0 S − wave e + ν e = 5.41 ± 0.35 stat . ± 0.37 syst . × 10 − 4 $$ \mathcal{B}\left({D}^{+}\to {\left({K}_S^0{\pi}^0\right)}_{S-\textrm{wave}}{e}^{+}{\nu}_e\right)=\left(5.41\pm {0.35}_{\textrm{stat}.}\pm {0.37}_{\textrm{syst}.}\right)\times {10}^{-4} $$ and B D + → K ¯ ∗ 892 0 e + ν e = 4.97 ± 0.11 stat . ± 0.12 syst . % $$ \mathcal{B}\left({D}^{+}\to {\overline{K}}^{\ast }{(892)}^0{e}^{+}{\nu}_e\right)=\left(4.97\pm {0.11}_{\textrm{stat}.}\pm {0.12}_{\textrm{syst}.}\right)\% $$ . In addition, the hadronic form-factor ratios of D + → K ¯ ∗ 892 0 e + ν e $$ {D}^{+}\to {\overline{K}}^{\ast }{(892)}^0{e}^{+}{\nu}_e $$ at q 2 = 0, assuming a single-pole dominance parameterization, are determined to be r V = V 0 A 1 0 = 1.43 ± 0.07 stat . ± 0.03 syst . $$ {r}_V=\frac{V(0)}{A_1(0)}=1.43\pm {0.07}_{\textrm{stat}.}\pm {0.03}_{\textrm{syst}.} $$ and r 2 = A 2 0 A 1 0 = 0.72 ± 0.06 stat . ± 0.02 syst . $$ {r}_2=\frac{A_2(0)}{A_1(0)}=0.72\pm {0.06}_{\textrm{stat}.}\pm {0.02}_{\textrm{syst}.} $$ .

Published
2024
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13. The basic characteristics of active faults in the region of Xigaze，Xizang and the assessment of potential earthquake disaster risks

Author

Ting Huang, Zhonghai Wu, Shuai Han, Yang Gao, and Weiguo Bai

Subjects
the region of xigaze, active fault, earthquake disaster, risk assessment, Geology, QE1-996.5, Engineering (General). Civil engineering (General), TA1-2040
Abstract

China is one of the countries in the world with the most frequent occurrence of continental earthquakes and the greatest impacts of earthquake disasters. In particular, the Qinghai-Tibet Plateau is a region characterized by a wide spatial distribution of continental earthquakes, shallow epicenters, complex seismic origins, and significant disaster losses, making it highly susceptible to seismic events. The need for seismic geological survey is becoming increasingly urgent in this area. Based on regional geological eological data，high-precision satellite remote sensing images and DEM elevation data，this paper interprets the active faults in the region of Xigaze. The results show that the active faults in the Xigaze area are mainly concentrated in the rift valleys and their periphery, with tectonic activity varying spatially. The tectonic activity of active faults in the eastern rift is stronger than that in the western rifts. Additionally，the tectonic activity of active faults in each rift also shows a clear segmentation feature. At the same time, this paper comprehensively considers the characteristics of active faults, topography and geomorphology and stratigraphic lithology in the Xigaze area. It preliminarily evaluates the potential risk of earthquake disasters in 204 towns under its jurisdiction. The results show that there are 57 towns with “extremely high risk” “high risk” and “high-medium risk” of earthquake disasters, accounting for about 28% of the total number of towns in the region.

Published
2024
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14. SUMOylation of Warts kinase promotes neural stem cell reactivation

Author

Yang Gao, Ye Sing Tan, Jiaen Lin, Liang Yuh Chew, Htet Yamin Aung, Brinda Palliyana, Mahekta R. Gujar, Kun-Yang Lin, Shu Kondo, and Hongyan Wang

Subjects
Science
Abstract

Abstract A delicate balance between neural stem cell (NSC) quiescence and proliferation is important for adult neurogenesis and homeostasis. Small ubiquitin-related modifier (SUMO)-dependent post-translational modifications cause rapid and reversible changes in protein functions. However, the role of the SUMO pathway during NSC reactivation and brain development is not established. Here, we show that the key components of the SUMO pathway play an important role in NSC reactivation and brain development in Drosophila. Depletion of SUMO/Smt3 or SUMO conjugating enzyme Ubc9 results in notable defects in NSC reactivation and brain development, while their overexpression leads to premature NSC reactivation. Smt3 protein levels increase with NSC reactivation, which is promoted by the Ser/Thr kinase Akt. Warts/Lats, the core protein kinase of the Hippo pathway, can undergo SUMO- and Ubc9-dependent SUMOylation at Lys766. This modification attenuates Wts phosphorylation by Hippo, leading to the inhibition of the Hippo pathway, and consequently, initiation of NSC reactivation. Moreover, inhibiting Hippo pathway effectively restores the NSC reactivation defects induced by SUMO pathway inhibition. Overall, our study uncovered an important role for the SUMO-Hippo pathway during Drosophila NSC reactivation and brain development.

Published
2024
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15. Fracture mechanism and constitutive model considering post-peak plastic deformation of marble under thermal–mechanical action

Author

Meiben Gao, Tianbin Li, Liang Zhang, Yang Gao, Zhihao He, and Yuyi Zhong

Subjects
Marble, Temperature, Fracture mechanism, Post-peak characteristics, Constitutive model, Dissipation energy, Geophysics. Cosmic physics, QC801-809
Abstract

Abstract Temperature plays an important impact on rock mechanical properties. In this paper, the mechanical properties, fracture mechanism and constitutive model of marble under 20–120 °C and 15 MPa are studied. The results show marble deformation can be divided into four stages: compaction, linear elasticity, crack propagation and post-peak failure. Stress–strain curve is not obviously affected by temperature. Macroscopic fracture characteristics change from shear failure to tensile mixed failure with temperature increasing. With the increase of temperature, the strength of marble tends to decrease, indicating that temperature increase has a weakening effect on marble, and there are temperature-sensitive areas of 20–60 °C and temperature sub-sensitive areas of 60–120 °C. The elastic modulus of marble decreases and Poisson’s ratio increases with increasing temperature. The energy evolution law of marble under different temperature is basically the same, which shows that before crack initiation, the energy dissipation is less, and after the damage and yielding occurs, the energy dissipation increases quickly. The energy dissipation in the failure process is mainly used for crack initiation-connection-penetration, as well as plastic deformation caused by friction and slip of cracks, and the plastic deformation and energy dissipation have good linear characteristics. The statistical damage constitutive model based on three-parameter Weibull distribution function can effectively reflect the characteristics of post-peak plastic deformation and strain softening. The weakening effect of marble at 20–120 °C is related to its internal moisture excitation. With the increase of temperature, water is stimulated to absorb and attach to the original relatively dry interface, which plays a role in lubrication. The relative motion friction resistance between solid particles or crack surfaces decreases, which leads to crack initiation and friction energy consumption reduction, changes the specific surface energy of rocks and weakens the strength of marble. The results provide a theoretical basis for predicting and evaluating the long-term stability and safety of surrounding rock of underground deep engineering in complex environment with high ground temperature and high geo-stress.

Published
2024
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16. How educational inequality affects family multichild behavior—evidence from super high schools

Author

Yang Gao, Hongling Xie, Qiannan Wang, and Chen Chen

Subjects
History of scholarship and learning. The humanities, AZ20-999, Social Sciences
Abstract

Abstract In a context characterized by the dual issues of educational inequality and problems with fertility, the internal relationship between these two factors requires further in-depth exploration. On the basis of data drawn from the China Family Panel Studies (CFPS) from 2010 to 2018, this paper investigates whether “super high schools” in cities represent a form of educational inequality, uses a combination of a two-way fixed effect model with the instrumental variable method to discuss the influence of this situation on family fertility and the corresponding transmission mechanism, develops a proportional risk regression model, and expands our understanding of the influence of educational inequality on the second-child birth interval. This study reveals that educational inequality significantly suppresses the number of family births and that the paths of action associated with this effect include both the explicit and implicit costs of education. The inhibitory effect of educational inequality on the number of family births varies according to urban grade, urban or rural classification, and the education levels attained by women. In addition to decreasing the number of family births, educational inequality increases the second-child birth interval. This paper not only enriches related research on family multichild behavior but also provides an educational reference for attempts to address the issue of continuously low fertility rates in China and establish a connection between population and educational economics.

Published
2024
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17. New ultrasound features in diagnosing fetal anal atresia: a multicenter prospective cohort study

Author

Haiyan Kuang, Hui Cao, Sheng Wang, Yingchun Luo, Yang Gao, Lingyu Yan, Junyi Yan, and Yulin Peng

Subjects
Ultrasonography, Anus, Imperforate, Incidence, Diagnostic tests, Medicine, Science
Abstract

Abstract This research aimed to assess the validity of ultrasound scans with new features in detecting fetal anal atresia and verify the effectiveness of these new features. Additionally, we aimed at investigating the perinatal incidence of anal atresia. This multicenter prospective study recruited 94,617 normal gravidas and 84 gravidas with anal atresia fetuses. The gold standard for diagnosing perinatal anal atresia is routine neonatal anus examinations. The incidence calculation was based on the results of the gold standard. The validity of our new approach was evaluated via a diagnostic test involving all 94,701 subjects. The effectiveness of our new features was assessed through an ablation study in a randomly established new dataset, with the ratio of anal atresia to non-anal atresia cases of 1:4. The annual perinatal incidence of anal atresia between 2019 and 2023 ranges from 0.57‰ to 1.29‰. Our new method performed great regarding the Youden index, diagnostic odds ratio (DOR), area under the curve (AUC) of the receiver operating characteristic curve (ROCC), AUC of the precision-recall curve (PRC), F1-score, and Cramer’s V. In the ablation study, our new approach surpassed its competitors concerning Youden index, DOR, AUC of the ROCC, and AUC of the PRC. Ultrasound scans show high validity and clinical value in detecting fetal anal atresia. Our new ultrasound features significantly promote the detection of fetal anal atresia.

Published
2024
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18. Exploring EFL University Teachers' Beliefs in Integrating ChatGPT and Other Large Language Models in Language Education: A Study in China

Author

Yang Gao, Qikai Wang, and Xiaochen Wang

Abstract

Nowadays, the prevalence of ChatGPT and other Large Language Models (LLMs) has posed significant challenges into the education field, particularly in English education. In response, this study aimed to investigate the beliefs of 95 EFL university teachers from Chinese universities regarding the integration of LLMs in language education, as well as the relationships between their beliefs and other factors. The study yielded several findings: (1) According to the quantitative and qualitative results, we revealed several concerns among Chinese EFL university teachers regarding LLMs integration, such as neglection of traditional learning resources, academic integrity, and excessive reliance. (2) Previous experiences with LLMs, frequency of LLMs use, and self-evaluation on stages of LLMs integration all played vital roles in shaping university teachers' beliefs in integrating LLMs in language education. (3) No significant correlation was observed between university teachers' beliefs in integrating LLMs in language education and the availability of IT personnel. (4) No significant correlation was observed between university teachers' beliefs in integrating LLMs in language education their evaluation on IT infrastructure. This research has provided some insights into university teachers' beliefs in ChatGPT and other LLMs to promote effective policies and strategies in the digital era.

Published
2024
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19. Optimization of ribosome profiling in plants including structural analysis of rRNA fragments

Author

Michael K. Y. Ting, Yang Gao, Rouhollah Barahimipour, Rabea Ghandour, Jinghan Liu, Federico Martinez-Seidel, Julia Smirnova, Vincent Leon Gotsmann, Axel Fischer, Michael J. Haydon, Felix Willmund, and Reimo Zoschke

Subjects
Arabidopsis thaliana, Nicotiana tabacum, Translation, Ribosome profiling, Ribo-seq, Guidelines, Plant culture, SB1-1110, Biology (General), QH301-705.5
Abstract

Abstract Background Ribosome profiling (or Ribo-seq) is a technique that provides genome-wide information on the translational landscape (translatome). Across different plant studies, variable methodological setups have been described which raises questions about the general comparability of data that were generated from diverging methodologies. Furthermore, a common problem when performing Ribo-seq are abundant rRNA fragments that are wastefully incorporated into the libraries and dramatically reduce sequencing depth. To remove these rRNA contaminants, it is common to perform preliminary trials to identify these fragments because they are thought to vary depending on nuclease treatment, tissue source, and plant species. Results Here, we compile valuable insights gathered over years of generating Ribo-seq datasets from different species and experimental setups. We highlight which technical steps are important for maintaining cross experiment comparability and describe a highly efficient approach for rRNA removal. Furthermore, we provide evidence that many rRNA fragments are structurally preserved over diverse nuclease regimes, as well as across plant species. Using a recently published cryo-electron microscopy (cryo-EM) structure of the tobacco 80S ribosome, we show that the most abundant rRNA fragments are spatially derived from the solvent-exposed surface of the ribosome. Conclusion The guidelines presented here shall aid newcomers in establishing ribosome profiling in new plant species and provide insights that will help in customizing the methodology for individual research goals.

Published
2024
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20. The progress and future of the treatment of Candida albicans infections based on nanotechnology

Author

Yang Gao, Qinyan Cao, Yuyang Xiao, Yue Wu, Liang Ding, He Huang, Yanan Li, Jingpeng Yang, and Lingtong Meng

Subjects
Nanomedicine, Candida albicans, Hyphae, Subcellular organelles, Drug resistance, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
Abstract

Abstract Systemic infection with Candida albicans poses a significant risk for people with weakened immune systems and carries a mortality rate of up to 60%. However, current therapeutic options have several limitations, including increasing drug tolerance, notable off-target effects, and severe adverse reactions. Over the past four decades, the progress in developing drugs to treat Candida albicans infections has been sluggish. This comprehensive review addresses the limitations of existing drugs and summarizes the efforts made toward redesigning and innovating existing or novel drugs through nanotechnology. The discussion explores the potential applications of nanomedicine in Candida albicans infections from four perspectives: nano-preparations for anti-biofilm therapy, innovative formulations of “old drugs” targeting the cell membrane and cell wall, reverse drug resistance therapy targeting subcellular organelles, and virulence deprivation therapy leveraging the unique polymorphism of Candida albicans. These therapeutic approaches are promising to address the above challenges and enhance the efficiency of drug development for Candida albicans infections. By harnessing nano-preparation technology to transform existing and preclinical drugs, novel therapeutic targets will be uncovered, providing effective solutions and broader horizons to improve patient survival rates. Graphical abstracts

Published
2024
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21. Sugars and organic acids components of different provenances Choerospondias axillaries fruit

Author

Yang Gao, Ceng Kun JIANG, Yu Cauo Zhao, Chun Feng Xia, Chao Nan Kan, Nan heng Wu, Fei Ding, and Yi Ping Zou

Subjects
choerospondias axillaris, provenances, soluble sugars, organic acids, cluster analysis, Agriculture (General), S1-972
Abstract

Choerospondias axillaries (CA) is an important fast-growing afforestation tree species in southern China, and its fruit has medicinal and edible value. High performance liquid chromatography was used to determine the composition and content of sugar and acid in CA fruits from different provenances, and cluster analysis was conducted on different provenances. The results showed that the total sugar content of CA fruit ranged from 49.31 to 139.41 mg/g, with sucrose accounting for the highest proportion of total sugar, followed by glucose, and fructose was the lowest. The total acid content of CA fruit ranged from 47.97 to 82.81 mg/g, with citric acid accounting for 67.09% of the total acid, followed by ascorbic acid, quinic acid, tartaric acid, and malic acid. Cluster analysis was conducted on 20 CA fruits, which were divided into 4 categories. It was recommended to develop N19 fruit had the highest content of sucrose and glucose, and the highest sweetness value, sugar-acid ratio and sweet-acid ratio. It can be suggested to be developed as a high-sugar fresh food source. N02 fruit with high sugar and high acid content can be used as a raw material for fruit cake processing. This result provides an important reference for the quality evaluation and rational development and utilization of CA.

Published
2024

22. Observation of the semileptonic decays D 0 → K S 0 π − π 0 e + ν e $$ {\textrm{D}}^0\to {\textrm{K}}_{\textrm{S}}^0{\pi}^{-}{\pi}^0{\textrm{e}}^{+}{\nu}_{\textrm{e}} $$ and D + → K S 0 π + π − e + ν e $$ {\textrm{D}}^{+}\to {\textrm{K}}_{\textrm{S}}^0{\pi}^{+}{\pi}^{-}{\textrm{e}}^{+}{\nu}_{\textrm{e}} $$

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, X. C. Ai, R. Aliberti, A. Amoroso, M. R. An, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, T. T. Chang, W. L. Chang, G. R. Che, G. Chelkov, C. Chen, Chao Chen, G. Chen, H. S. Chen, M. L. Chen, S. J. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, W. S. Cheng, S. K. Choi, X. Chu, G. Cibinetto, S. C. Coen, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Z. H. Duan, P. Egorov, Y. L. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, K. Fischer, M. Fritsch, C. Fritzsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, Z. L. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, T. T. Han, W. Y. Han, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, H. M. Hu, J. F. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, T. Hussain, N. Hüsken, W. Imoehl, J. Jackson, S. Jaeger, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, H. J. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, T. Johansson, X. Kui, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, R. Kappert, M. Kavatsyuk, B. C. Ke, A. Khoukaz, R. Kiuchi, R. Kliemt, O. B. Kolcu, B. Kopf, M. Kuessner, A. Kupsc, W. Kühn, J. J. Lane, P. Larin, A. Lavania, L. Lavezzi, T. T. Lei, Z. H. Lei, H. Leithoff, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, J. W. Li, K. L. Li, Ke Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. X. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. H. Li, X. L. Li, Xiaoyu Li, Y. G. Li, Z. J. Li, Z. X. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, L. Z. Liao, Y. P. Liao, J. Libby, A. Limphirat, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. H. Liu, Fang Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. M. Liu, Huanhuan Liu, Huihui Liu, J. B. Liu, J. L. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. L. Ma, J. L. Ma, L. L. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, R. T. Ma, X. Y. Ma, Y. Ma, Y. M. Ma, F. E. Maas, M. Maggiora, S. Malde, Q. A. Malik, A. Mangoni, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, I. B. Nikolaev, Z. Ning, S. Nisar, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, P. Patteri, Y. P. Pei, M. Pelizaeus, H. P. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, S. Pogodin, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, J. J. Qin, L. Q. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, S. Q. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, V. Rodin, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, R. S. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. T. Sun, Y. X. Tan, C. J. Tang, G. Y. Tang, J. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, C. W. Wang, D. Y. Wang, F. Wang, H. J. Wang, H. P. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, Meng Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. H. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. Wei, D. H. Wei, F. Weidner, S. P. Wen, C. W. Wenzel, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. C. Xu, Z. P. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, Tao Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Yifan Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, T. Yu, X. D. Yu, C. Z. Yuan, L. Yuan, S. C. Yuan, X. Q. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. H. Zhang, H. Q. Zhang, H. Y. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, Jiawei Zhang, L. M. Zhang, L. Q. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, Shuihan Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y. Zhang, Xuyan Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Yan Zhang, Yao Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, G. Zhao, J. Zhao, J. Y. Zhao, J. Z. Zhao, Lei Zhao, Ling Zhao, M. G. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, L. P. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, J. Zhu, K. Zhu, K. J. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, S. Q. Zhu, T. J. Zhu, W. J. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
Branching fraction, Charm Physics, e +-e − Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract By analyzing e + e − annihilation data corresponding to an integrated luminosity of 2.93 fb −1 collected at a center-of-mass energy of 3.773 GeV with the BESIII detector, the first observation of the semileptonic decays D 0 → K S 0 π − π 0 e + ν e $$ {D}^0\to {K}_S^0{\pi}^{-}{\pi}^0{e}^{+}{\nu}_e $$ and D + → K S 0 π + π − e + ν e $$ {D}^{+}\to {K}_S^0{\pi}^{+}{\pi}^{-}{e}^{+}{\nu}_e $$ is reported. In the hypothesis that all events correspond to K 1(1270) decays, the branching fractions are measured to be B D 0 → K 1 1270 − → K S 0 π − π 0 e + ν e = 1.69 − 0.46 + 0.53 ± 0.15 × 10 − 4 $$ \mathcal{B}\left({D}^0\to {K}_1{(1270)}^{-}\left(\to {K}_S^0{\pi}^{-}{\pi}^0\right){e}^{+}{\nu}_e\right)=\left({1.69}_{-0.46}^{+0.53}\pm 0.15\right)\times {10}^{-4} $$ and B D + → K ¯ 1 1270 0 → K S 0 π + π − e + ν e = 1.47 − 0.40 + 0.45 ± 0.14 × 10 − 4 $$ \mathcal{B}\left({D}^{+}\to {\overline{K}}_1{(1270)}^0\left(\to {K}_S^0{\pi}^{+}{\pi}^{-}\right){e}^{+}{\nu}^e\right)=\left({1.47}_{-0.40}^{+0.45}\pm 0.14\right)\times {10}^{-4} $$ with statistical significance of 5.4σ and 5.6σ, respectively. When combined with measurements of the K 1(1270) → K + π − π decays, the absolute branching fractions are determined to be B D 0 → K 1 1270 − e + ν e = 1.08 − 0.13 − 0.10 + 0.14 + 0.08 ± 0.21 × 10 − 3 $$ \mathcal{B}\left({D}^0\to {K}_1{(1270)}^{-}{e}^{+}{\nu}_e\right)=\left({1.08}_{-0.13-0.10}^{+0.14+0.08}\pm 0.21\right)\times {10}^{-3} $$ and B D + → K ¯ 1 1270 0 e + ν e = 1.70 − 0.23 + 0.26 ± 0.13 ± 0.35 × 10 − 3 $$ \mathcal{B}\left({D}^{+}\to {\overline{K}}_1{(1270)}^0{e}^{+}{\nu}_e\right)=\left({1.70}_{-0.23}^{+0.26}\pm 0.13\pm 0.35\right)\times {10}^{-3} $$ . The first and second uncertainties are statistical and systematic, respectively, and the third uncertainties originate from the assumed branching fractions of the K 1(1270) → Kππ decays.

Published
2024
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23. Perceived tourism implicit conflict among community residents and its spatial variation

Author

Yangyang Li, Xiao Feng, Yang Gao, and Zhenbin Zhao

Subjects
History of scholarship and learning. The humanities, AZ20-999, Social Sciences
Abstract

Abstract This study explores tourism implicit conflict and its spatial dynamics in rural China. It proposes that residents in different spatial structures within tourism communities perceive implicit conflicts differently. Data were collected through public participatory geographic information system (PPGIS) mapping and semi-structured interviews. The findings reveal that conflict perceptions vary by residential structures. Residents in core and peripheral areas experienced heightened economic and cultural conflicts. In contrast, those in expanded areas were more concerned with issues of tourism governance. The study also highlights two key spatial aspects of perceived conflict: internality, the overlap within their residential areas, and significant externality, which spreads across the entire ancient town. From a combined spatial and psychological perspective, this study proposes the concept of spatial relative deprivation to explain resident’s perceived tourism implicit conflict. This study affirms that qualitative-spatial analysis sheds light on socio-cultural phenomena, contributing to a more nuanced understanding of the underlying conflict mechanisms in a spatially explicit manner. The findings suggest that tourism planning should consider the intrinsic and micro-values of communities.

Published
2024
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24. Alginate oligosaccharide supplementation improves boar semen quality under heat stress

Author

Yexun Zhou, Zeou Wei, Jiajian Tan, Haiqing Sun, Haidi Jiang, Yang Gao, Hongfu Zhang, and Martine Schroyen

Subjects
Heat stress, Alginate oligosaccharides (AOS), Semen quality, Gut microbiota, Sperm metabolome, Sperm proteome, Biology (General), QH301-705.5
Abstract

Abstract Heat stress is a serious problem that affects animal husbandry by reducing growth and reproductive performance of animals. Adding plant extracts to the diet is an effective way to help overcome this problem. Alginate oligosaccharide (AOS) is a natural non-toxic antioxidant with multiple biological activities. This study analyzed the potential mechanism of AOS in alleviating heat stress and improving semen quality in boars through a combination of multiple omics tools. The results indicated that AOS could significantly increase sperm motility (P

Published
2024
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25. Stabilization of dimeric PYR/PYL/RCAR family members relieves abscisic acid-induced inhibition of seed germination

Author

Zhi-Zheng Wang, Min-Jie Cao, Junjie Yan, Jin Dong, Mo-Xian Chen, Jing-Fang Yang, Jian-Hong Li, Rui-Ning Ying, Yang-Yang Gao, Li Li, Ya-Nan Leng, Yuan Tian, Kamalani Achala H. Hewage, Rong-Jie Pei, Zhi-You Huang, Ping Yin, Jian-Kang Zhu, Ge-Fei Hao, and Guang-Fu Yang

Subjects
Science
Abstract

Abstract Abscisic acid (ABA) is the primary preventing factor of seed germination, which is crucial to plant survival and propagation. ABA-induced seed germination inhibition is mainly mediated by the dimeric PYR/PYL/RCAR (PYLs) family members. However, little is known about the relevance between dimeric stability of PYLs and seed germination. Here, we reveal that stabilization of PYL dimer can relieve ABA-induced inhibition of seed germination using chemical genetic approaches. Di-nitrobensulfamide (DBSA), a computationally designed chemical probe, yields around ten-fold improvement in receptor affinity relative to ABA. DBSA reverses ABA-induced inhibition of seed germination mainly through dimeric receptors and recovers the expression of ABA-responsive genes. DBSA maintains PYR1 in dimeric state during protein oligomeric state experiment. X-ray crystallography shows that DBSA targets a pocket in PYL dimer interface and may stabilize PYL dimer by forming hydrogen networks. Our results illustrate the potential of PYL dimer stabilization in preventing ABA-induced seed germination inhibition.

Published
2024
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26. Association of novel DNAH11 variants with asthenoteratozoospermia lead to male infertility

Author

Senzhao Guo, Dongdong Tang, Yuge Chen, Hui Yu, Meng Gu, Hao Geng, Jiajun Fang, Baoyan Wu, Lewen Ruan, Kuokuo Li, Chuan Xu, Yang Gao, Qing Tan, Zongliu Duan, Huan Wu, Rong Hua, Rui Guo, Zhaolian Wei, Ping Zhou, Yuping Xu, Yunxia Cao, Xiaojin He, Yanwei Sha, and Mingrong Lv

Subjects
Male infertility, Asthenoteratozoospermia, WES, DNAH11, ICSI, Medicine, Genetics, QH426-470
Abstract

Abstract Background Bi-allelic variants in DNAH11 have been identified as causative factors in Primary Ciliary Dyskinesia, leading to abnormal respiratory cilia. Nonetheless, the specific impact of these variants on human sperm flagellar and their involvement in male infertility remain largely unknown. Methods A collaborative effort involving two Chinese reproductive centers conducted a study with 975 unrelated infertile men. Whole-exome sequencing was employed for variant screening, and Sanger sequencing confirmed the identified variants. Morphological and ultrastructural analyses of sperm were conducted using Scanning Electron Microscopy and Transmission Electron Microscopy. Western Blot Analysis and Immunofluorescence Analysis were utilized to assess protein levels and localization. ICSI was performed to evaluate its efficacy in achieving favorable pregnancy outcomes for individuals with DNAH11 variants. Results In this study, we identified seven novel variants in the DNAH11 gene in four asthenoteratozoospermia subjects. These variants led the absence of DNAH11 proteins and ultrastructure defects in sperm flagella, particularly affecting the outer dynein arms (ODAs) and adjacent structures. The levels of ODA protein DNAI2 and axoneme related proteins were down regulated, instead of inner dynein arms (IDA) proteins DNAH1 and DNAH6. Two out of four individuals with DNAH11 variants achieved clinical pregnancies through ICSI. The findings confirm the association between male infertility and bi-allelic deleterious variants in DNAH11, resulting in the aberrant assembly of sperm flagella and contributing to asthenoteratozoospermia. Importantly, ICSI emerges as an effective intervention for overcoming reproductive challenges caused by DNAH11 gene variants.

Published
2024
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27. Measurements of K S 0 $$ {K}_S^0 $$ - K L 0 $$ {K}_L^0 $$ asymmetries in the decays Λ c + → p K L , S 0 $$ {\Lambda}_c^{+}\to p{K}_{L,S}^0 $$ , p K L , S 0 π + π − $$ p{K}_{L,S}^0{\pi}^{+}{\pi}^{-} $$ and p K L , S 0 π 0 $$ p{K}_{L,S}^0{\pi}^0 $$

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, G. R. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, L. Ge, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, J. J. Lane, L. Lavezzi, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, K. L. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, L. R. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. Ma, Y. M. Ma, F. E. Maas, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, X. K. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, S. S Su, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. Xu, Y. C. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Junhao Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, M. C. Yu, T. Yu, X. D. Yu, Y. C. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, Z. Z. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, Z. C. Zhou, A. N. Zhu, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, T. J. Zhu, W. D. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
Charm Physics, e +-e − Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Using e + e − annihilation data sets corresponding to an integrated luminosity of 4.5 fb −1, collected with the BESIII detector at center-of-mass energies between 4.600 and 4.699 GeV, we report the first measurements of the absolute branching fractions B Λ c + → p K L 0 $$ \mathcal{B}\left({\Lambda}_c^{+}\to p{K}_L^0\right) $$ = (1.67 ± 0.06 ± 0.04)%, B Λ c + → p K L 0 π + π − $$ \mathcal{B}\left({\Lambda}_c^{+}\to p{K}_L^0{\pi}^{+}{\pi}^{-}\right) $$ = (1.69 ± 0.10 ± 0.05)%, and B Λ c + → p K L 0 π 0 $$ \mathcal{B}\left({\Lambda}_c^{+}\to p{K}_L^0{\pi}^0\right) $$ = (2.02 ± 0.13 ± 0.05)%, where the first uncertainties are statistical and the second systematic. Combining with the known branching fractions of Λ c + → p K S 0 $$ {\Lambda}_c^{+}\to p{K}_S^0 $$ , Λ c + → p K S 0 π + π − $$ {\Lambda}_c^{+}\to p{K}_S^0{\pi}^{+}{\pi}^{-} $$ , and Λ c + → p K S 0 π 0 $$ {\Lambda}_c^{+}\to p{K}_S^0{\pi}^0 $$ , we present the first measurements of the K S 0 $$ {K}_S^0 $$ - K L 0 $$ {K}_L^0 $$ asymmetries R Λ c + K S , L 0 X = B Λ c + → K S 0 X − B Λ c + → K L 0 X B Λ c + → K S 0 X + B Λ c + → K L 0 X $$ R\left({\Lambda}_c^{+},{K}_{S,L}^0X\right)=\frac{\mathcal{B}\left({\Lambda}_c^{+}\to {K}_S^0X\right)-\mathcal{B}\left({\Lambda}_c^{+}\to {K}_L^0X\right)}{\mathcal{B}\left({\Lambda}_c^{+}\to {K}_S^0X\right)+\mathcal{B}\left({\Lambda}_c^{+}\to {K}_L^0X\right)} $$ in charmed baryon decays: R Λ c + p K S , L 0 = − 0.025 ± 0.031 $$ R\left({\Lambda}_c^{+},p{K}_{S,L}^0\right)=-0.025\pm 0.031 $$ , R Λ c + p K S , L 0 π + π − = − 0.027 ± 0.048 $$ R\left({\Lambda}_c^{+},p{K}_{S,L}^0{\pi}^{+}{\pi}^{-}\right)=-0.027\pm 0.048 $$ and R Λ c + p K S , L 0 π 0 = − 0.015 ± 0.046 $$ R\left({\Lambda}_c^{+},p{K}_{S,L}^0{\pi}^0\right)=-0.015\pm 0.046 $$ . No significant asymmetries with statistical significance are observed.

Published
2024
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28. Offshore wind farm operation contributed to a slight improvement in seawater quality along the Jiangsu Coast, China

Author

Zhudeng Wei, Minyan Wang, Yang Gao, Wenzheng Yu, Aiqing Jia, Zhiyuan You, and Zhihong Wang

Subjects
Offshore wind farm, Surface seawater pollution, Environmental impact assessment, Renewable energy, Jiangsu coastal area, Medicine, Science
Abstract

Abstract The rapid growth of offshore wind farms (OWFs) is driven by concerns for energy security and climate change mitigation. However, their impact on marine environments remains poorly understood due to limited research. This study analyzes the effects of an OWF along China's Jiangsu Coast on seawater quality using data from different development phases. Results show the major pollutants were different across phases. Heavy metal pollution reached alert levels during construction compared to the safe levels observed in the pre-construction and operational phases, mainly due to increases in Pb, Cd, and Hg concentrations. Eutrophication was mild throughout all periods but exhibited a continuous decrease, primarily attributed to reductions in PH and COD concentrations. As a result, the comprehensive pollution level during construction was increased, but it was improved to a clean level during the operational phase. Besides, significant variations were observed in the spatial distribution patterns of major pollutant indices across different scenarios. These changes may stem from a combination effect of land-based pollution, aquaculture, OWF-induced disturbances to atmosphere and hydrodynamics, OWF-related drain and leakage contamination, and marine management policies. Understanding these effects informs OWF optimization, rational wind resource utilization, and marine ecology protection.

Published
2024
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29. Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases

Author

Xinyue Jiang, Hongzhan Wang, Kexin Nie, Yang Gao, Shen Chen, Yueheng Tang, Zhi Wang, Hao Su, and Hui Dong

Subjects
Lipid droplet, Lipid droplet-associated proteins, Metabolic diseases, Natural compounds, Other systems of medicine, RZ201-999
Abstract

Abstract Background Lipid droplet (LD) is a metabolically active organelle, which changes dynamically with the metabolic state and energy requirements of cells. Proteins that either insert into the LD phospholipid monolayer or are present in the cytoplasm, playing a crucial role in lipid homeostasis and signaling regulation, are known as LD-associated proteins. Methods The keywords “lipid droplets” and “metabolic diseases” were used to obtain literature on LD metabolism and pathological mechanism. After searching databases including Scopus, OVID, Web of Science, and PubMed from 2013 to 2024 using terms like “lipid droplets”, “lipid droplet-associated proteins”, “fatty liver disease”, “diabetes”, “diabetic kidney disease”, “obesity”, “atherosclerosis”, “hyperlipidemia”, “natural drug monomers” and “natural compounds”, the most common natural compounds were identified in about 954 articles. Eventually, a total of 91 studies of 10 natural compounds reporting in vitro or in vivo studies were refined and summarized. Results The most frequently used natural compounds include Berberine, Mangostin, Capsaicin, Caffeine, Genistein, Epigallocatechin-3-gallate, Chlorogenic acid, Betaine, Ginsenoside, Resveratrol. These natural compounds interact with LD-associated proteins and help ameliorate abnormal LDs in various metabolic diseases. Conclusion Natural compounds involved in the regulation of LDs and LD-associated proteins hold promise for treating metabolic diseases. Further research into these interactions may lead to new therapeutic applications. Graphical Abstract

Published
2024
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30. Correlation between anesthetic concentration and low Apgar scores in neonates born via Cesarean sections under general anesthesia

Author

Yang Gao, Yun Song, Jingkun Miao, Xiaofeng Lei, Hao Liu, Lin Gan, Meng Cai, and Jin Yu

Subjects
General anesthesia, Cesarean section, Neonatal outcome, Apgar score, Anesthetics, Correlation analysis, Pediatrics, RJ1-570
Abstract

Abstract Objectives This study aimed to compare plasma concentrations of anesthetic drugs administered during Cesarean section with low Apgar score in neonates deliveried under general anesthesia and analyze associated risk factors. Methods Data from 76 neonates undergoing Cesarean section under general anesthesia with blood concentrations of anesthetic drugs were analyzed. A low Apgar score was defined as ≤ 7. Perioperative maternal and neonatal data were collected and analyzed. Neonates were divided into a control group (Group CON, n = 65) and a low Apgar score group (Group LAS, n = 11) based on Apgar score. Results There were no significant differences in the plasma concentrations of anesthetic drugs in maternal artery, umbilical vein or umbilical artery blood between the two groups. Risk factors for neonatal low Apgar scores during Cesarean section under general anesthesia were premature delivery (aOR 10.2, 95% CI = 1.8–56.9) and preoperative fetal distress (aOR 9.6, 95% CI = 1.3–69.0). The prediction model was: probability = 1/(e‑Y), Y= -4.607 + 2.318× (premature delivery) + 2.261× (fetal distress) (yes = 1, no = 0). The Hosmer–Lemeshow test showed χ²= 9.587, P = 0.213, and the area under the curve (AUC) was 0.850 (0.670 ~ 1.000). With a cutoff value of 0.695, sensitivity and specificity were 81.8% and 87.7%, respectively. Conclusions There was no correlation between blood concentration of general anesthetic drugs and Apgar score or occurrence of neonatal low Apgar scores. Premature delivery and preoperative fetal distress were identified as independent risk factors for neonatal low Apgar scores after Cesarean section under general anesthesia.

Published
2024
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31. Optimization of Complex Enzyme Extraction Process of Astragalus Polysaccharides and Its α-Glucosidase Inhibitory Activities

Author

Huijia ZHANG, Xiangzhu HOU, Han ZHANG, Ao YIN, Yang GAO, and Duoduo XU

Subjects
astragalus polysaccharides (aps), complex enzymes, extraction process, response surface, α-glucosidase activity, Food processing and manufacture, TP368-456
Abstract

Objective: To extract Astragalus polysaccharides (APS) from Astragalus membranaceus using compound enzymes (including papain, pectinase and cellulase), and to analyze the effect of process conditions on APS extraction. Methods: Orthogonal experiments were conducted to determine the proportion of compound enzymes. The response surface method was used to optimize the conditions of extracting APS with compound enzymes. The optimal process condition was obtained, and the α-glucosidase-inhibiting effect of APS was evaluated by pNPG method. Results: For 5 g of Astragalus herbs, the optimal ratio of papain, pectinase and cellulase were 88000 U, 65000 U and 6000 U, respectively. The optimal extraction condition was as follows: time of 2.82 h, temperature at 60.34 ℃, pH of 5.11, and solid-liquid ratio of 1:34.46 g/mL. The yield of APS under the optimal condition was up to 22.79%±0.14%. The half-inhibition concentration (IC50) of APS for α-glucosidase was 7.42 μg/mL. Conclusion: The yield of APS by compound enzymes is significantly higher than that by single enzymes, and APS can effectively inhibit the activity of α-glucosidase.

Published
2024
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32. Effect of anterior segment structure on vault and position after implantable collamer lens implantation

Author

Qin Wang, Xiao Chen, Li Li, Lin Zhou, Yang Gao, Li Shen, Shaomin Peng, and Qizhi Zhou

Subjects
anterior-segment structure, implantable collamer lens, maximum ciliary body thickness, trabecular-ciliary angle, vault, Ophthalmology, RE1-994
Abstract

Purpose: To evaluate the effect of anterior-segment structure on vault and position after implantable collamer lens (ICL) implantation using ultrasound biomicroscopy. Methods: The retrospective case-control study included insufficient vault eyes (750 µm). The preoperative biometric parameters of the anterior-segment structure and basic data between the three groups were analyzed using one-way analysis of variance. Results: There were significant differences (P < 0.05) between the three groups in maximum ciliary body thickness (CBTmax), iris-zonule distance (IZD), and trabecular-ciliary angle (TCA). The vault gradually decreased as CBTmax decreased and TCA increased. In the pairwise comparison, the CBTmax comparison between the insufficient vault (750 µm) group was statistically significant (P = 0.024, 95% CI: −0.17–0.017 µm); the TCA comparison between the insufficient vault (750 µm) group was statistically significant (P = 0.005, 95% CI: 1.78°–12.15°); The IZD comparison between the insufficient vault (750 µm) group was statistically significant (P = 0.037, 95% CI: 0.0027–0.1119 µm). The analysis of 284 ICL haptics locations showed that there were 16.67%, 32.69%, and 70.83% haptics located in the ciliary sulcus in three groups, respectively. Conclusion: The vault and ICL haptics position are related to anterior-segment structure. A thinner and posteriorly positioned ciliary body would increase the risk of low vault and fewer ICL haptics located in the ciliary sulcus after ICL implantation. This provides guidance for the selection of the ICL size and placement position before surgery.

Published
2024
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33. Improved measurement of the branching fraction of h c → γη′/η and search for h c → γπ 0

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H. -R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, G. R. Che, Y. Z. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, L. Ge, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, J. J. Lane, L. Lavezzi, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, K. L. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, L. R. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. M. Ma, F. E. Maas, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, X. K. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, M. Q. Ruan, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, S. S Su, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. H. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. Xu, Y. C. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, J. H. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Junhao Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, M. C. Yu, T. Yu, X. D. Yu, Y. C. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, Z. Z. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, A. N. Zhu, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, T. J. Zhu, W. D. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
Branching fraction, e +-e − Experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The processes h c → γP (P = η′, η, π 0) are studied with a sample of (27.12 ± 0.14) × 108 ψ(3686) events collected by the BESIII detector at the BEPCII collider. The decay h c → γη is observed for the first time with the significance of 9.0 σ, and the branching fraction is determined to be (3.77 ± 0.55 ± 0.13 ± 0.26) × 10 −4, while B $$ \mathcal{B} $$ (h c → γη′) is measured to be (1.40 ± 0.11 ± 0.04 ± 0.10) × 10 −3, where the first uncertainties are statistical, the second systematic, and the third from the branching fraction of ψ(3686) → π 0 h c . The combination of these results allows for a precise determination of R h c = B h c → γη B h c → γ η ′ , $$ {R}_{h_c}=\frac{\mathcal{B}\left({h}_c\to {\pi}^0\gamma \eta \right)}{\mathcal{B}\left({h}_c\to {\pi}^0\gamma {\eta}^{\prime}\right)}, $$ which is calculated to be (27.0 ± 4.4 ± 1.0)%. The results are valuable for gaining a deeper understanding of η − η′ mixing, and its manifestation within quantum chromodynamics. No significant signal is found for the decay h c → γπ 0, and an upper limit is placed on its branching fraction of B $$ \mathcal{B} $$ (h c → γπ 0) < 5.0 × 10 −5, at the 90% confidence level.

Published
2024
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34. Prior carbapenem exposure increases the incidence of ventilator-associated pneumonia in critically Ill children

Author

Xuguo Wang, Mutian Zheng, Yue Zhang, Yang Gao, Leihua Jiang, Saihu Huang, Xue Wang, Chunmei Su, Wensi Niu, Shuiyan Wu, and Zhenjiang Bai

Subjects
Antibiotic exposure, Ventilator-Associated Pneumonia (VAP), Mechanical ventilation, Carbapenems, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Prior antibiotic exposure has been identified as a risk factor for VAP occurrence, making it a growing concern among clinical practitioners. But there is a lack of systematic research on the types of antibiotics and the duration of exposure that influence VAP occurrence in children at current. Methods We retrospectively reviewed 278 children admitted to the Pediatric Intensive Care Unit (PICU) and underwent invasive mechanical ventilation (MV) between January 2020 and December 2022. Of these, 171 patients with MV duration ≥ 48 h were included in the study, with 61 of them developing VAP (VAP group) and the remaining 110 as the non-VAP group. We analyzed the relationship between early antibiotic exposure and VAP occurrence. Results The incidence of VAP was 21.94% (61/278). The VAP group had significantly longer length of hospital stay (32.00 vs. 20.00 days, p

Published
2024
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35. Microbial assimilatory sulfate reduction-mediated H2S: an overlooked role in Crohn’s disease development

Author

Wanrong Luo, Min Zhao, Mohammed Dwidar, Yang Gao, Liyuan Xiang, Xueting Wu, Marnix H. Medema, Shu Xu, Xiaozhi Li, Hendrik Schäfer, Minhu Chen, Rui Feng, and Yijun Zhu

Subjects
Inflammatory bowel disease, Inorganic sulfate, Sulfopolysaccharide, 3’-Phosphoadenosine-5’-Phosphosulfate PAPS, Adenosine-5’-Phosphosulfate APS, Microbial ecology, QR100-130
Abstract

Abstract Background H2S imbalances in the intestinal tract trigger Crohn's disease (CD), a chronic inflammatory gastrointestinal disorder characterized by microbiota dysbiosis and barrier dysfunction. However, a comprehensive understanding of H2S generation in the gut, and the contributions of both microbiota and host to systemic H2S levels in CD, remain to be elucidated. This investigation aimed to enhance comprehension regarding the sulfidogenic potential of both the human host and the gut microbiota. Results Our analysis of a treatment-naive CD cohorts' fecal metagenomic and biopsy metatranscriptomic data revealed reduced expression of host endogenous H2S generation genes alongside increased abundance of microbial exogenous H2S production genes in correlation with CD. While prior studies focused on microbial H2S production via dissimilatory sulfite reductases, our metagenomic analysis suggests the assimilatory sulfate reduction (ASR) pathway is a more significant contributor in the human gut, given its high prevalence and abundance. Subsequently, we validated our hypothesis experimentally by generating ASR-deficient E. coli mutants ∆cysJ and ∆cysM through the deletion of sulfite reductase and L-cysteine synthase genes. This alteration significantly affected bacterial sulfidogenic capacity, colon epithelial cell viability, and colonic mucin sulfation, ultimately leading to colitis in murine model. Further study revealed that gut microbiota degrade sulfopolysaccharides and assimilate sulfate to produce H2S via the ASR pathway, highlighting the role of sulfopolysaccharides in colitis and cautioning against their use as food additives. Conclusions Our study significantly advances understanding of microbial sulfur metabolism in the human gut, elucidating the complex interplay between diet, gut microbiota, and host sulfur metabolism. We highlight the microbial ASR pathway as an overlooked endogenous H2S producer and a potential therapeutic target for managing CD. Video Abstract

Published
2024
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36. Long-term safety and influence on growth in patients receiving sirolimus: a pooled analysis

Author

Yang-Yang Wang, Li-Ping Zou, Kai-Feng Xu, Wen-Shuai Xu, Meng-Na Zhang, Qian Lu, Xin-Lun Tian, Ling-Yu Pang, Wen He, Qiu-Hong Wang, Yang Gao, Li-Ying Liu, Xiao-Qiao Chen, Shu-Fang Ma, Hui-Min Chen, Shuo Dun, Xiao-Yan Yang, Xiao-Mei Luo, Lu-Lu Huang, and Yu-Fen Li

Subjects
Sirolimus, Tuberous sclerosis, Safety, Adverse events, Physical growth, Medicine
Abstract

Abstract Background Sirolimus is increasingly utilized in treating diseases associated with mTOR pathway overactivation. Despite its potential, the lack of evidence regarding its long-term safety across all age groups, particularly in pediatric patients, has limited its further application. This study aims to assess the long-term safety of sirolimus, with a specific focus on its impact on growth patterns in pediatric patients. Methods This pooled analysis inlcudes two prospective cohort studies spanning 10 years, including 1,738 participants (aged 5 days to 69 years) diagnosed with tuberous sclerosis and/or lymphangioleiomyomatosis. All participants were mTOR inhibitor-naive and received 1 mg/m²/day of sirolimus, with dose adjustments during a two-week titration period to maintain trough blood concentrations between 5 and 10 ng/ml (maximum dose 2 mg). Indicators of physical growth, hematopoietic, liver, renal function, and blood lipid levels were all primary outcomes and were analyzed. The adverse events and related management were also recorded. Results Sirolimus administration did not lead to deviations from normal growth ranges, but higher doses exhibited a positive association with Z-scores exceeding 2 SD in height, weight, and BMI. Transient elevations in red blood cell and white blood cell counts, along with hyperlipidemia, were primarily observed within the first year of treatment. Other measured parameters remained largely unchanged, displaying only weak correlations with drug use. Stomatitis is the most common adverse event (920/1738, 52.9%). In adult females, menstrual disorders were observed in 48.5% (112/217). Conclusions Sirolimus’s long-term administration is not associated with adverse effects on children’s physical growth pattern, nor significant alterations in hematopoietic, liver, renal function, or lipid levels. A potential dose-dependent influence on growth merits further exploration. Trial registration Pediatric patients: Chinese clinical trial registry, No. ChiCTR-OOB-15,006,535. Adult patients: ClinicalTrials, No. NCT03193892.

Published
2024
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37. Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag

Author

Ellen H. Brumbaugh-Reed, Yang Gao, Kazuhiro Aoki, and Jared E. Toettcher

Subjects
Science
Abstract

Abstract Biomolecular condensates are broadly implicated in both normal cellular regulation and disease. Consequently, several chemical biology and optogenetic approaches have been developed to induce phase separation of a protein of interest. However, few tools are available to perform the converse function – dissolving a condensate of interest on demand. Such a tool would aid in testing whether the condensate plays specific functional roles. Here we show that light-gated recruitment of a solubilizing domain, maltose-binding protein (MBP), results in rapid and controlled dissolution of condensates formed from proteins of interest. Our optogenetic MBP-based dissolution strategy (OptoMBP) is rapid, reversible, and can be spatially controlled with subcellular precision. We also provide a proof-of-principle application of OptoMBP by disrupting condensation of the oncogenic fusion protein FUS-CHOP and reverting FUS-CHOP driven transcriptional changes. We envision that the OptoMBP system could be broadly useful for disrupting constitutive protein condensates to probe their biological functions.

Published
2024
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38. The interface structure and property of magnesium matrix composites: A review

Author

Hongwei Xiong, Lidong Gu, Jingya Wang, Liping Zhou, Tao Ying, Shiwei Wang, Haitao Zhou, Jianbo Li, Yang Gao, and Xiaoqin Zeng

Subjects
Mg matrix composites, interface, interfacial strength, interfacial modification, Mining engineering. Metallurgy, TN1-997
Abstract

Magnesium matrix composites have garnered significant attention in recent years owing to their exceptional lightweight properties and notable potential in various engineering applications. The interface generally acts as a “bridge” between the matrix and reinforcement, playing crucial roles in critical processes such as load transfer, failure behavior, and carrier transport. A deep understanding of the interfacial structures, properties, and effects holds paramount significance in the study of composites. This paper presents a comprehensive review of prior researches related to the interface of Mg matrix composites. Firstly, the different interfacial structures and interaction mechanisms encompassing mechanical, physical, and chemical bonding are introduced. Subsequently, the interfacial mechanical properties and their influence on the overall properties are discussed. Finally, the paper addresses diverse interface modification methods including matrix alloying and reinforcement surface treatment.

Published
2024
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39. CRISPR/Cas9-mediated knockout of E4 gene promotes maturation in soybean

Author

Shuiqing Wu, Li Chen, Mengwei Guo, Yupeng Cai, Yang Gao, Shan Yuan, Shi Sun, Yuxian Zhang, Wensheng Hou, and Tianfu Han

Subjects
Soybean, E4, CRISPR/Cas9, Maturity, Genetics, QH426-470
Abstract

Soybean is a broadly popular and extensively cultivated crop, however, many high-yield and high-quality varieties require specific growth conditions, restricting their widespread adoption. The appropriate light conditions and photoperiod must be attained for these varieties to thrive in new environments. In this study, we employed CRISPR/Cas9 to design two sgRNAs aimed at knocking out the maturity-related gene E4 in a major American soybean variety called ''Jack'', which belongs to maturity group MGII. E4 gene is primarily involved in the photoperiodic flowering and maturity in soybean, making it an ideal candidate for genetic manipulation. We successfully obtained 1 homozygous E4-SG1 mutant type with 1-bp insertion, and 4 homozygous E4-SG2 mutants type with 2-bp deletion, 7-bp deletion, 61-bp deletion, and 1-bp insertion, respectively. The homozygous e4 mutant plants contained early termination codons devoid of transgenic elements. Additionally, no potential off-target sites of the E4 gene were detected. A comparative analysis revealed that, unlike the wild-type, the maturity time of homozygous e4 mutants was early under both short-day and long-day conditions. These mutants offer novel germplasm resources that may be used to modify the photoperiod sensitivity and maturity of soybean, enhancing its adaptability to high-latitude regions.

Published
2024
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40. Investigation on the safety of regular plasma donors aged 56-60 years

Author

Yang GAO, Kecheng DONG, Mingli MA, Yan DONG, Donghong FANG, Yumeng SU, Rong ZHOU, and Demei DONG

Subjects
plasma, plasma donors aged 56 to 60, adverse reaction to plasma donation, age, Diseases of the blood and blood-forming organs, RC633-647.5, Medicine
Abstract

Objective To investigate the safety of regular plasma donors aged 55 to 60, so as to provide reference for retention and recruitment of elderly plasma donors in China. Methods Plasma donors from 9 blood products manufacturing enterprises from 2018 to 2020 and the local general population were selected as the research objects. The total protein level, albumin and globulin ratio(ALB/GLB, A/G) and adverse reactions of plasma donation of regular plasma donors and local general population were retrospectively analyzed. Results The total protein level (g/L) and A/G of plasma donors aged 56 to 60 and the general population were 61.21±5.62 vs 60.04±6.93 and 1.610±0.299 vs 1.635±0.330, respectively, and the differences were statistically significant. The total protein level of regular plasma donors was higher than that of general population, but A/G was slightly lower than that of general population. From 2018 to 2020, there were a total of 23 056 302 plasma donations in 108 plasma stations, and adverse reactions occurred in 20 932 donations, with a total incidence of 0.09%, with no serious adverse reactions. Conclusion It is safe for regular plasma donors aged 55 to 60 to donate plasma, and the retention of them can alleviate the pressure of plasma supply.

Published
2024
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41. Comparison of femoral tunnel position and knee function in anterior cruciate ligament reconstruction: a retrospective cohort study using measuring-fluoroscopy method versus bony marker method

Author

Yan Dong, Yang Gao, Peng Cui, Yuanming He, and Guke Yao

Subjects
ACL rupture, Anatomical reconstruction, Bony landmarks, Measuring method, Apex, Cartilage, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Previous studies have shown that surgical technique errors especially the wrong bone tunnel position are the primary reason for the failure of anterior cruciate ligament (ACL) reconstruction. In this study, we aimed to compare the femoral tunnel position and impact on knee function during the ACL reconstruction using measuring combined with fluoroscopy method and bony marker method for femoral tunnel localization. Methods A retrospective cohort study of patients undergoing ACL reconstruction using the bony marker method or measuring combined with fluoroscopy for femoral tunnel localization was conducted between January 2015 and January 2020. A second arthroscopic exploration was performed more than 1 year after surgery. Data regarding patient demographics, the femoral tunnel position, results of the Lysholm score, the International Knee Documentation Committee (IKDC) score, KT-1000 side-to-side difference, pivot shift grade, and Lachman grade of the knee were collected. Results A total of 119 patients were included in the final cohort. Of these, 42 cases were in the traditional method group, and 77 cases were in the measuring method group. The good tunnel position rate was 26.2% in the traditional method group and 81.8% in the measuring method group (p

Published
2024
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42. Measurement of the cross sections of e + e − → K − Ξ ¯ + Λ / Σ 0 $$ {e}^{+}{e}^{-}\to {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ at center-of-mass energies between 3.510 and 4.914 GeV

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, G. R. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, H. Y. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Y. Y. Duan, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, X. B. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, L. Ge, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, F. Hanisch, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, S. L. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Y. S. Huang, T. Hussain, F. Hölzken, N. Hüsken, N. in der Wiesche, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, N. Kumar, A. Kupsc, W. Kühn, J. J. Lane, P. Larin, L. Lavezzi, T. T. Lei, Z. H. Lei, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, K. Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, X. Y. Li, X. Z. Li, Y. G. Li, Z. J. Li, Z. Y. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, L. Z. Liao, Y. P. Liao, J. Libby, A. Limphirat, C. C. Lin, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. Liu, F. H. Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. H. Liu, H. M. Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, J. R. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, T. Ma, X. T. Ma, X. Y. Ma, Y. Ma, Y. M. Ma, F. E. Maas, M. Maggiora, S. Malde, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, L. S. Nie, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, P. Patteri, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, X. K. Qiao, J. J. Qin, L. Q. Qin, L. Y. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, Z. J. Shang, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, M. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, M. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. C. Xu, Z. P. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, T. Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, T. Yu, X. D. Yu, Y. C. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. R. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. S. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, R. Y. Zhang, S. H. Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, Z. Z. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, L. Zhao, Lei Zhao, M. G. Zhao, N. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, B. M. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, S. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, J. Zhu, K. Zhu, K. J. Zhu, K. S. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, S. Q. Zhu, T. J. Zhu, W. D. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
e +-e − Experiments, QCD, Particle and Resonance Production, Branching fraction, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Using e + e − collision data collected with the BESIII detector at the BEPCII collider at center-of-mass energies between 3.510 and 4.914 GeV, corresponding to an integrated luminosity of 25 fb −1, we measure the Born cross sections for the process e + e − → K − Ξ ¯ + Λ / Σ 0 $$ {e}^{+}{e}^{-}\to {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ at thirty-five energy points with a partial-reconstruction strategy. By fitting the dressed cross sections of e + e − → K − Ξ ¯ + Λ / Σ 0 $$ {e}^{+}{e}^{-}\to {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ , evidence for ψ 4160 → K − Ξ ¯ + Λ $$ \psi (4160)\to {K}^{-}{\overline{\Xi}}^{+}\Lambda $$ is found for the first time with a significance of 4.4σ, including systematic uncertainties. No evidence for other possible resonances is found. In addition, the products of electronic partial width and branching fraction for all assumed resonances decaying into K − Ξ ¯ + Λ / Σ 0 $$ {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ are determined.

Published
2024
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43. Mechanism of acupoint penetration acupuncture therapy regulating chondrocyte autophagy via the PI3K/Akt-mTOR pathway in KOA rats

Author

Yang Gao, Qingbo Wang, Songwei Li, Xiaojing Shi, Shan Dai, Jingjing Yu, Qingpan Zhao, Yang Wang, and Youlong Zhou

Subjects
Acupoint penetration acupuncture, Knee osteoarthritis, Chondrocyte, Autophagy, Apoptosis, Cell proliferation, Miscellaneous systems and treatments, RZ409.7-999
Abstract

Objective: To investigate whether acupoint penetration acupuncture (APA) could regulate chondrocyte autophagy and apoptosis via the PI3K/Akt-mTOR signaling pathway to reduce cartilage degeneration in knee osteoarthritis (KOA) rats. Methods: KOA was induced in rats via intra-articular injection of sodium iodoacetate resolution. Forty male Sprague-Dawley rats were randomly assigned to blank control, model, APA, electro-acupuncture (EA), and sham model groups (n = 8) and those in the APA and EA groups received their respective therapies. Following completion of the treatment course, histological examinations of cartilage and muscle were conducted. Levels of apoptosis- and autophagy-related factors, including Bax, Bcl-2, mTOR, ULK-1, and Beclin-1 protein, and mRNAs were assessed. Additionally, β-endorphin (β-EP) concentrations in the brain and serum were measured. Results: Histological analysis revealed that APA alleviated cartilage and muscle damage compared with the model group. APA inhibited cartilage degeneration by modulating the expression of apoptosis- and autophagy-related proteins and mRNA, thus preventing chondrocyte apoptosis. In the APA group, Bax and mTOR protein levels were significantly lower than those in the model group (both P = .024). Conversely, the Bcl-2 expression level was significantly higher than that in the EA group (P = .035). Additionally, ULK-1 expression was significantly lower than that in the EA group (P = .045). The mRNA level of Bax was significantly higher than that in the blank control group (P

Published
2024
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44. Study of η′ → π + π − l + l − decays at BESIII

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, O. Afedulidis, X. C. Ai, R. Aliberti, A. Amoroso, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, H.-R. Bao, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, W. L. Chang, G. R. Che, G. Chelkov, C. Chen, C. H. Chen, Chao Chen, G. Chen, H. S. Chen, M. L. Chen, S. J. Chen, S. L. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, Z. Y. Chen, S. K. Choi, X. Chu, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, C. Q. Deng, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Z. H. Duan, P. Egorov, Y. H. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, Y. Q. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, Y. T. Feng, K. Fischer, M. Fritsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, Y. T. Gu, C. Y. Guan, Z. L. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, J. Gutierrez, K. L. Han, T. T. Han, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, B. Y. Hu, H. M. Hu, J. F. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, T. Hussain, F. Hölzken, N Hüsken, N. in der Wiesche, M. Irshad, J. Jackson, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, W. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, D. Jiang, H. B. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, J. K. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, X. M. Jing, T. Johansson, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, M. Kavatsyuk, B. C. Ke, V. Khachatryan, A. Khoukaz, R. Kiuchi, O. B. Kolcu, B. Kopf, M. Kuessner, X. Kui, A. Kupsc, W. Kühn, J. J. Lane, P. Larin, L. Lavezzi, T. T. Lei, Z. H. Lei, H. Leithoff, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, Ke Li, L. J Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. M. Li, Q. X. Li, R. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. Li, X. H. Li, X. L. Li, Xiaoyu Li, Y. G. Li, Z. J. Li, Z. X. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, L. Z. Liao, Y. P. Liao, J. Libby, A. Limphirat, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. H. Liu, Fang Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. M. Liu, Huanhuan Liu, Huihui Liu, J. B. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. D. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. Ma, H. L. Ma, J. L. Ma, L. L. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, X. T. Ma, X. Y. Ma, Y. Ma, Y. M. Ma, F. E. Maas, M. Maggiora, S. Malde, A. Mangoni, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, B. Moses, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, I. B. Nikolaev, Z. Ning, S. Nisar, Q. L. Niu, W. D. Niu, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, P. Patteri, Y. P. Pei, M. Pelizaeus, H. P. Peng, Y. Y. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, J. J. Qin, L. Q. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, S. Q. Qu, Z. H. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, R. S. Shi, S. Y. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, S. Sosio, S. Spataro, F. Stieler, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. Q. Sun, Z. T. Sun, C. J. Tang, G. Y. Tang, J. Tang, Y. A. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, Y. Wan, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, D. Y. Wang, F. Wang, H. J. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, Meng Wang, N. Y. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, X. N. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. L. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. Wei, D. H. Wei, F. Weidner, S. P. Wen, Y. R. Wen, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. H. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, B. H. Xiang, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. C. Xu, Z. P. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, Tao Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Yifan Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, T. Yu, X. D. Yu, C. Z. Yuan, J. Yuan, L. Yuan, S. C. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, S. H. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. C. Zhang, H. H. Zhang, H. Q. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, L. M. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, Shuihan Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Y. M. Zhang, Yan Zhang, Yao Zhang, Z. D. Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, G. Zhao, J. Y. Zhao, J. Z. Zhao, Lei Zhao, Ling Zhao, M. G. Zhao, R. P. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, J. Y. Zhou, L. P. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, J. Zhu, K. Zhu, K. J. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, S. Q. Zhu, T. J. Zhu, W. J. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
e +-e − Experiments, QCD, CP Violation, Dark Matter, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract With a sample of (10087 ± 44) × 106 J/ψ events accumulated with the BESIII detector, we analyze the decays η′ → π + π − l + l − (l = e, μ) via the process J/ψ → γη′. The branching fractions are measured to be B $$ \mathcal{B} $$ (η′ → π + π − e + e − ) = (2.45 ± 0.02(stat.) ± 0.08(syst.)) × 10 −3 and B $$ \mathcal{B} $$ (η′ → π + π − μ + μ − ) = (2.16 ± 0.12(stat.) ± 0.06(syst.)) × 10 −5, and the ratio is B η ′ → π + π − e + e − B η ′ → π + π − μ + μ − = 113.4 ± 0.9 stat . ± 3.7 syst . $$ \frac{\mathcal{B}\left({\eta}^{\prime}\to {\pi}^{+}{\pi}^{-}{e}^{+}{e}^{-}\right)}{\mathcal{B}\left({\eta}^{\prime}\to {\pi}^{+}{\pi}^{-}{\mu}^{+}{\mu}^{-}\right)}=113.4\pm 0.9\left(\textrm{stat}.\right)\pm 3.7\left(\textrm{syst}.\right) $$ . In addition, by combining the η′ → π + π − e + e − and η′ → π + π − μ + μ − decays, the slope parameter of the electromagnetic transition form factor is measured to be b η′ = 1.30 ± 0.19 (GeV/c 2) −2, which is consistent with previous measurements from BESIII and theoretical predictions from the VMD model. The asymmetry in the angle between the π + π − and l + l − decay planes, which has the potential to reveal the CP-violation originating from an unconventional electric dipole transition, is also investigated. The asymmetry parameters are determined to be A CP η ′ → π + π − e + e − = − 0.21 ± 0.73 stat . ± 0.01 syst . % $$ {\mathcal{A}}_{CP}\left({\eta}^{\prime}\to {\pi}^{+}{\pi}^{-}{e}^{+}{e}^{-}\right)=\left(-0.21\pm 0.73\left(\textrm{stat}.\right)\pm 0.01\left(\textrm{syst}.\right)\right)\% $$ and A CP η ′ → π + π − μ + μ − = 0.62 ± 4.71 stat . ± 0.08 syst . % $$ {\mathcal{A}}_{CP}\left({\eta}^{\prime}\to {\pi}^{+}{\pi}^{-}{\mu}^{+}{\mu}^{-}\right)=\left(0.62\pm 4.71\left(\textrm{stat}.\right)\pm 0.08\left(\textrm{syst}.\right)\right)\% $$ , implying that no evidence of CP-violation is observed at the present statistics. Finally, an axion-like particle is searched for via the decay η′ → π + π − a, a → e + e − , and upper limits of the branching fractions are presented for the mass assumptions of the axion-like particle in the range of 0 − 500 MeV/c 2.

Published
2024
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45. Has China’s hierarchical medical system improved doctor-patient relationships?

Author

Yang Gao, Yang Yang, Shoupeng Wang, Wenqian Zhang, and Jiao Lu

Subjects
Healthy China, Hierarchical Medical System, Doctor-Patient relationships, Resource misallocation, Difference-in-Differences Analysis, Medicine (General), R5-920
Abstract

Abstract Background and objective Developing harmonious doctor-patient relationships is a powerful way to promote the construction of a new pattern of medical reform in developing countries. We aim to analyze the effects of China’s hierarchical medical system on doctor-patient relationships, thus contributing to China’s medical and health system reform. Methods With panel data on prefectural-level cities in China from 2012 to 2019, we used a time-varying difference-in-differences model to evaluate the effect of hierarchical medical treatment policy. Results Hierarchical medical treatment policies can significantly improve doctor-patient relationships, and this conclusion is supported by various robustness tests. And improving doctor-patient relationships can be indirectly realized by the optimization of resource allocation and saving of medical costs. In addition, the marginal effect of the pilot policy on doctor-patient relationships decreased with age within the city population. In focal cities and cities with high levels of fiscal spending on health care, the effect of the pilot policy on doctor-patient relationships was stronger. Conclusion While reinforcing the literature on the doctor-patient relationship, this study also provides a reference for further exploration of the pilot policy of hierarchical medical treatment and the development of new medical and health system reform in developing countries.

Published
2024
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46. Multistate transition and coupled solid–liquid modeling of motion process of long-runout landslide

Author

Yang Gao, Yueping Yin, Bin Li, Han Zhang, Weile Wu, and Haoyuan Gao

Subjects
Long-runout landslide, Multistate transition, Mixed solid‒liquid flow, Post-failure process, Numerical simulation, Engineering geology. Rock mechanics. Soil mechanics. Underground construction, TA703-712
Abstract

The recognition, repetition and prediction of the post-failure motion process of long-runout landslides are key scientific problems in the prevention and mitigation of geological disasters. In this study, a new numerical method involving LPF3D based on a multialgorithm and multiconstitutive model was proposed to simulate long-runout landslides with high precision and efficiency. The following results were obtained: (a) The motion process of landslides showed a steric effect with mobility, including gradual disintegration and spreading. The sliding mass can be divided into three states (dense, dilute and ultradilute) in the motion process, which can be solved by three dynamic regimes (friction, collision, and inertial); (b) Coupling simulation between the solid grain and liquid phases was achieved, focusing on drag force influences; (c) Different algorithms and constitutive models were employed in phase-state simulations. The volume fraction is an important indicator to distinguish different state types and solid‒liquid ratios. The flume experimental results were favorably validated against long-runout landslide case data; and (d) In this method, matched dynamic numerical modeling was developed to better capture the realistic motion process of long-runout landslides, and the advantages of continuum media and discrete media were combined to improve the computational accuracy and efficiency. This new method can reflect the realistic physical and mechanical processes in long-runout landslide motion and provide a suitable method for risk assessment and pre-failure prediction.

Published
2024
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47. Measurement of e + e − → ωη′ cross sections at s $$ \sqrt{s} $$ = 2.000 to 3.080 GeV

Author

The BESIII collaboration, M. Ablikim, M. N. Achasov, P. Adlarson, X. C. Ai, R. Aliberti, A. Amoroso, M. R. An, Q. An, Y. Bai, O. Bakina, I. Balossino, Y. Ban, V. Batozskaya, K. Begzsuren, N. Berger, M. Berlowski, M. Bertani, D. Bettoni, F. Bianchi, E. Bianco, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, T. T. Chang, W. L. Chang, G. R. Che, G. Chelkov, C. Chen, Chao Chen, G. Chen, H. S. Chen, M. L. Chen, S. J. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Y. Q. Chen, Z. J. Chen, W. S. Cheng, S. K. Choi, X. Chu, G. Cibinetto, S. C. Coen, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, B. Ding, X. X. Ding, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, M. C. Du, S. X. Du, Z. H. Duan, P. Egorov, Y. H. Y. Fan, Y. L. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, K Fischer, M. Fritsch, C. Fritzsch, C. D. Fu, J. L. Fu, Y. W. Fu, H. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, S. Gramigna, M. Greco, M. H. Gu, C. Y Guan, Z. L. Guan, A. Q. Guo, L. B. Guo, M. J. Guo, R. P. Guo, Y. P. Guo, A. Guskov, T. T. Han, W. Y. Han, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, T. Holtmann, P. C. Hong, G. Y. Hou, X. T. Hou, Y. R. Hou, Z. L. Hou, H. M. Hu, J. F. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, T. Hussain, N Hüsken, W. Imoehl, J. Jackson, S. Jaeger, S. Janchiv, J. H. Jeong, Q. Ji, Q. P. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, X. Q. Jia, Z. K. Jia, H. J. Jiang, P. C. Jiang, S. S. Jiang, T. J. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, T. Johansson, X. Kui, S. Kabana, N. Kalantar-Nayestanaki, X. L. Kang, X. S. Kang, R. Kappert, M. Kavatsyuk, B. C. Ke, A. Khoukaz, R. Kiuchi, R. Kliemt, O. B. Kolcu, B. Kopf, M. Kuessner, A. Kupsc, W. Kühn, J. J. Lane, P. Larin, A. Lavania, L. Lavezzi, T. T. Lei, Z. H. Lei, H. Leithoff, M. Lellmann, T. Lenz, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. Li, H. B. Li, H. J. Li, H. N. Li, Hui Li, J. R. Li, J. S. Li, J. W. Li, K. L. Li, Ke Li, L. J Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, Q. X. Li, S. X. Li, T. Li, W. D. Li, W. G. Li, X. H. Li, X. L. Li, Xiaoyu Li, Y. G. Li, Z. J. Li, C. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, L. Z. Liao, Y. P. Liao, J. Libby, A. Limphirat, D. X. Lin, T. Lin, B. J. Liu, B. X. Liu, C. Liu, C. X. Liu, F. H. Liu, Fang Liu, Feng Liu, G. M. Liu, H. Liu, H. M. Liu, Huanhuan Liu, Huihui Liu, J. B. Liu, J. L. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, L. C. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. L. Ma, J. L. Ma, L. L. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, R. T. Ma, X. Y. Ma, Y. Ma, Y. M. Ma, F. E. Maas, M. Maggiora, S. Malde, Q. A. Malik, A. Mangoni, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, N. Yu. Muchnoi, J. Muskalla, Y. Nefedov, F. Nerling, I. B. Nikolaev, Z. Ning, S. Nisar, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, P. Patteri, Y. P. Pei, M. Pelizaeus, H. P. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, S. Pogodin, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, C. F. Qiao, J. J. Qin, L. Q. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, S. Q. Qu, C. F. Redmer, K. J. Ren, A. Rivetti, V. Rodin, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, N. Salone, A. Sarantsev, Y. Schelhaas, K. Schoenning, M. Scodeggio, K. Y. Shan, W. Shan, X. Y. Shan, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, W. H. Shen, X. Y. Shen, B. A. Shi, H. C. Shi, J. L. Shi, J. Y. Shi, Q. Q. Shi, R. S. Shi, X. Shi, J. J. Song, T. Z. Song, W. M. Song, Y. J. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, Y. J. Su, G. B. Sun, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, K. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, Y. Sun, Y. J. Sun, Y. Z. Sun, Z. T. Sun, Y. X. Tan, C. J. Tang, G. Y. Tang, J. Tang, Y. A. Tang, L. Y Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, Z. F. Tian, I. Uman, S. J. Wang, B. Wang, B. L. Wang, Bo Wang, C. W. Wang, D. Y. Wang, F. Wang, H. J. Wang, H. P. Wang, J. P. Wang, K. Wang, L. L. Wang, M. Wang, Meng Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. P. Wang, X. Wang, X. F. Wang, X. J. Wang, X. L. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. H. Wang, Y. N. Wang, Y. Q. Wang, Yaqian Wang, Yi Wang, Z. Wang, Z. L. Wang, Z. Y. Wang, Ziyi Wang, D. Wei, D. H. Wei, F. Weidner, S. P. Wen, C. W. Wenzel, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, C. Wu, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. J. Wu, Z. Wu, L. Xia, X. M. Xian, T. Xiang, D. Xiao, G. Y. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, Q. J. Xu, Q. N. Xu, W. Xu, W. L. Xu, X. P. Xu, Y. C. Xu, Z. P. Xu, Z. S. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, X. Q. Yan, H. J. Yang, H. L. Yang, H. X. Yang, Tao Yang, Y. Yang, Y. F. Yang, Y. X. Yang, Yifan Yang, Z. W. Yang, Z. P. Yao, M. Ye, M. H. Ye, J. H. Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, J. S. Yu, T. Yu, X. D. Yu, C. Z. Yuan, L. Yuan, S. C. Yuan, X. Q. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, X. Zeng, Y. Zeng, Y. J. Zeng, X. Y. Zhai, Y. C. Zhai, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. H. Zhang, H. Q. Zhang, H. Y. Zhang, J. Zhang, J. J. Zhang, J. L. Zhang, J. Q. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, Jiawei Zhang, L. M. Zhang, L. Q. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, Shuihan Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y. Zhang, Xuyan Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Yan Zhang, Yao Zhang, Z. H. Zhang, Z. L. Zhang, Z. Y. Zhang, G. Zhao, J. Zhao, J. Y. Zhao, J. Z. Zhao, Lei Zhao, Ling Zhao, M. G. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, J. P. Zheng, W. J. Zheng, Y. H. Zheng, B. Zhong, X. Zhong, H. Zhou, L. P. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, J. Zhu, K. Zhu, K. J. Zhu, L. Zhu, L. X. Zhu, S. H. Zhu, S. Q. Zhu, T. J. Zhu, W. J. Zhu, Y. C. Zhu, Z. A. Zhu, J. H. Zou, and J. Zu

Subjects
e +-e − Experiments, Particle and Resonance Production, Spectroscopy, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We measured the Born cross sections for the process e + e − → ωη′ at 22 center-of-mass energies from 2.000 to 3.080 GeV with the BESIII detector at the BEPCII collider. We observed a resonant structure with a statistical significance of 9.6σ. A Breit-Wigner fit determines its mass to be M R = (2153 ± 30 ± 31) MeV/c 2 and its width to be Γ R = (167 ± 77 ± 7) MeV, where the first uncertainties are statistical and the second are systematic.

Published
2024
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48. Genome-wide analysis of the SWEET gene family in Hemerocallis citrina and functional characterization of HcSWEET4a in response to salt stress

Author

Lihong Cao, Jinyao Wang, Lixuan Wang, Huili Liu, Wenjing Wu, Feifan Hou, Yuting Liu, Yang Gao, Xiaojing Cheng, Sen Li, and Guoming Xing

Subjects
Hemerocallis citrina, SWEETs, Genome-wide, Abiotic stress, Functional characterization, Botany, QK1-989
Abstract

Abstract Sugars will be eventually effluxed transporters (SWEETs) have been confirmed to play diverse physiological roles in plant growth, development and stress response. However, the characteristics and functions of the SWEET genes in Hemerocallis citrina remain unclear and poorly elucidated. In this study, the whole genome of Hemerocallis citrina was utilized to conduct bioinformatics analysis and a total of 19 HcSWEET genes were successfully identified. Analysis of the physicochemical properties indicated dominant differences among these HcSWEETs. A phylogenetic analysis revealed that HcSWEET proteins can be divided into 4 clades ranging from Clade I to IV, where proteins within the same clade exhibited shared conserved motifs and gene structures. Five to six exons were contained in the majority of HcSWEET genes, which were unevenly distributed across 11 chromosomes. The gene duplication analysis showed the presence of 4 gene pairs. Comparative syntenic maps revealed that the HcSWEET gene family might present more closed homology in monocotyledons than dicotyledons. Cis-acting element analysis of HcSWEET genes indicated key responsiveness to various hormones, light, and stresses. Additionally, transcriptome sequencing analysis suggested that most HcSWEET genes had a relatively higher expression in roots, and HcSWEET4a was significantly up-regulated under salt stress. Overexpression further verified the possibility that HcSWEET4a was involved in response to salt stress, which provides novel insights and facilitates in-depth studies of the functional analysis of HcSWEETs in resistance to abiotic stress.

Published
2024
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49. Surface photogalvanic effect in Ag2Te

Author

Xiaoyi Xie, Pengliang Leng, Zhenyu Ding, Jinshan Yang, Jingyi Yan, Junchen Zhou, Zihan Li, Linfeng Ai, Xiangyu Cao, Zehao Jia, Yuda Zhang, Minhao Zhao, Wenguang Zhu, Yang Gao, Shaoming Dong, and Faxian Xiu

Subjects
Science
Abstract

Abstract The bulk photovoltaic effect (BPVE) in non-centrosymmetric materials has attracted significant attention in recent years due to its potential to surpass the Shockley-Queisser limit. Although these materials are strictly constrained by symmetry, progress has been made in artificially reducing symmetry to stimulate BPVE in wider systems. However, the complexity of these techniques has hindered their practical implementation. In this study, we demonstrate a large intrinsic photocurrent response in centrosymmetric topological insulator Ag2Te, attributed to the surface photogalvanic effect (SPGE), which is induced by symmetry reduction of the surface. Through diverse spatially-resolved measurements on specially designed devices, we directly observe that SPGE in Ag2Te arises from the difference between two opposite photocurrent flows generated from the top and bottom surfaces. Acting as an efficient SPGE material, Ag2Te demonstrates robust performance across a wide spectral range from visible to mid-infrared, making it promising for applications in solar cells and mid-infrared detectors. More importantly, SPGE generated on low-symmetric surfaces can potentially be found in various systems, thereby inspiring a broader range of choices for photovoltaic materials.

Published
2024
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50. Responses of soil microbial community characteristics and enzyme activities to different irrigation modes over four wheat-maize rotation seasons

Author

Dongfeng Ning, Qisheng Han, Yingying Zhang, Anzhen Qin, Zhandong Liu, Jiyang Zhang, and Yang Gao

Subjects
Drip irrigation, Deficit irrigation, Soil enzyme activities, Bacterial communities, Co-occurrence networks, Agriculture (General), S1-972, Agricultural industries, HD9000-9495
Abstract

Water scarcity in arid and semiarid areas highlights the importance of developing water-saving irrigation techniques. Soil extracellular enzyme activities (EEAs) and microbes are important for soil biochemical cycles and plant growth. However, little is understood about how soil EEAs, and microbial communities respond to water-saving irrigation systems and levels. Therefore, a field experiment was carried out over four consecutive wheat-maize seasons to explore the effects of surface irrigation (SI) and drip irrigation (DI) coupled with different irrigation levels (i.e. 65, 50, 35 and 20 mm/event, represents sufficient, mild deficit, moderate deficit and serious deficit irrigation, respectively) on the plant biomass, soil properties, soil EEAs, and bacterial community. The results revealed that mild deficit irrigation showed no significant impact on plant biomass, serious and moderate deficit irrigation significantly decreased crop biomass by 49.0 % and 26.6 %, respectively, compared with sufficient irrigation. However, the crop biomass of serious and moderate deficit irrigation under DI were 15.4 % and 17.4 % higher, respectively, than that under SI. Serious and moderate deficit irrigation significantly increased soil available K accumulation and soil urease activity, decreased bacterial richness, and shifted the bacterial community structure. No significant differences were found between mild deficit and sufficient irrigation. The relative abundances of Firmicutes, Gemmatimonadota, and Myxococcota significantly increased under serious deficit irrigation, while Acidobacteriota significantly decreased. Moderate deficit irrigation under DI did not shift bacterial community structure, while under SI did. Soil pH, electrical conductivity (EC), available K, and plant biomass were the major factors influencing the bacterial community compositions. Serious deficit irrigation reduced the complexity and stability of the soil bacterial co-occurrence network. The network of DI had more significant interactions among bacteria than the SI. Therefore, DI coupled with moderate deficit irrigation is more beneficial to maintain crop yield and the stability of bacterial community structure than SI.

Published
2024
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