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1,413 results on '"Yanagawa, Y."'

23. A case of lethal soft tissue injuries due to assault

Author

Yanagawa Y, Kanawaku Y, and Kanetake J

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Youichi Yanagawa,1 Yoshimasa Kanawaku,2 Jun Kanetake21Department of Emergency and Disaster Medicine, Juntendo University, Tokyo, 2Department of Forensic Medicine, National Defense Medical College, Saitama, JapanAbstract: A 42-year-old male had been assaulted by his family over the two previous days and went into a deep coma. When the emergency technician arrived, the patient was in a state of cardiopulmonary arrest. On arrival, his electrocardiogram showed asystole. His body showed swelling with subcutaneous hemorrhage, suggesting multiple contusional wounds. Serum biochemistry evaluation revealed blood urea nitrogen of 80 mg/dL, creatinine of 5.99 mg/dL, creatine phosphokinase of 10,094 IU/L, and potassium of 11.0 mEq/L. Advanced cardiopulmonary resuscitation failed to obtain a return of spontaneous circulation. Laboratory findings revealed rhabdomyolysis, renal failure, and hyperkalemia. Autopsy did not indicate the direct cause of death to be traumatic organ injuries. Because trauma was not the direct reason of death, we speculated that the patient died of hyperkalemia induced by multiple contusional soft tissue injuries, following rhabdomyolysis, hemolysis, and acute renal failure. The physician should maintain a high index of suspicion for hyperkalemia induced by rhabdomyolysis and acute renal failure, especially in patients presenting with symptoms of multiple soft tissue injuries with massive subcutaneous hemorrhaging.Keywords: contusion, rhabdomyolysis, renal failure, hyperkalemia

Published
2012

31. Experimental verification of scan-architecture-based evaluation technique of SET and SEU soft-error rates at each flip-flop in logic VLSI systems

Author

Yanagawa, Y., Kobayashi, D., Hirose, K., Makino, T., Saito, H., Ikeda, H., Onoda, S., Hirao, T., and Ohshima, T.

Subjects
Radiation -- Methods, Semiconductor industry -- Methods, Very-large-scale integration -- Methods, Arms control -- Verification, Arms control -- Methods, Semiconductor industry, Business, Electronics, Electronics and electrical industries
Published
2009

36. Direct measurement of SET pulse widths in 0.2-[micro]m SOI logic cells irradiated by heavy ions

Author

Yanagawa, Y., Hirose, K., Saito, H., Kobayashi, D., Fukuda, S., Ishii, S., Takahashi, D., Yamamoto, K., and Kuroda, Y.

Subjects
Heavy ions -- Research, Silicon-on-isolator -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Heavy-ion-induced SET-pulse widths in NOR-logic cells fabricated by a 0.2-[micro]m FD-SOI technology are directly measured by using an on-chip self-triggering Flip-Flop circuit. The pulse widths are distributed from 0.3 to 1.0 ns under a constant LET of 40 MeV x [cm.sup.2]/mg. Index Terms--Direct measurement, heavy ion irradiation, silicon on insulator technology, single event transient.

Published
2006

44. Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission

Author

Du, X, Hao, H, Yang, Y, Huang, S, Wang, C, Gigout, S, Ramli, R, Li, X, Jaworska, E, Edwards, I, Deuchars, J, Yanagawa, Y, Qi, J, Guan, B, Jaffe, DB, Zhang, H, and Gamper, N

Subjects
Nociception, Rats, Sprague-Dawley, nervous system, Ganglia, Spinal, Animals, Neuralgia, GABA Uptake Inhibitors, GABAergic Neurons, Rats, Wistar, Synaptic Transmission, Research Article, Rats
Abstract

The integration of somatosensory information is generally assumed to be a function of the central nervous system (CNS). Here we describe fully functional GABAergic communication within rodent peripheral sensory ganglia and show that it can modulate transmission of pain-related signals from the peripheral sensory nerves to the CNS. We found that sensory neurons express major proteins necessary for GABA synthesis and release and that sensory neurons released GABA in response to depolarization. In vivo focal infusion of GABA or GABA reuptake inhibitor to sensory ganglia dramatically reduced acute peripherally induced nociception and alleviated neuropathic and inflammatory pain. In addition, focal application of GABA receptor antagonists to sensory ganglia triggered or exacerbated peripherally induced nociception. We also demonstrated that chemogenetic or optogenetic depolarization of GABAergic dorsal root ganglion neurons in vivo reduced acute and chronic peripherally induced nociception. Mechanistically, GABA depolarized the majority of sensory neuron somata, yet produced a net inhibitory effect on the nociceptive transmission due to the filtering effect at nociceptive fiber T-junctions. Our findings indicate that peripheral somatosensory ganglia represent a hitherto underappreciated site of somatosensory signal integration and offer a potential target for therapeutic intervention.

Published
2017

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