1. With low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization
- Author
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Yan-Guang Wu, David H. Barad, Vitaly A. Kushnir, Qi Wang, Lin Zhang, Sarah K. Darmon, David F. Albertini, and Norbert Gleicher
- Subjects
In vitro fertilization (IVF) ,Advanced female age ,Premature ovarian aging (POA) ,Occult primary ovarian insufficiency (oPOI) ,Pregnancy rates ,Premature luteinization ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be for administration of ovulation-triggers. Methods Fifty-six women ≥43, and 37 POA patients underwent IVF cycles. Granulosa cells (GCs) were isolated, cultures were established, RNA was extracted and real-time PCR analyses performed, with gene expressions at mRNA level investigated for FSH receptor (FSHR), luteinizing hormone receptor (LHCPR), P450 aromatase (CYP19a1) and progesterone receptor (PGR). POA was defined by age
- Published
- 2018
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