Utilizing FMR1 gene mutations as predictors of treatment success in human in vitro fertilization.

Mutations of the fragile X mental retardation 1 (FMR1) gene are associated with distinct ovarian aging patterns.To confirm in human in vitro fertilization (IVF) that FMR1 affects outcomes, and to determine whether this reflects differences in ovarian aging between FMR1 mutations, egg/embryo quality or an effect on implantation.IVF outcomes were investigated in a private infertility center in reference to patients' FMR1 mutations based on a normal range of CGG(n = 26-34) and sub-genotypes high (CGG(n>34)) and low (CGG(