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14 results on '"Yakasai, Ahmed A."'

4. Community Pharmacists’ Knowledge and Attitudes Towards Pediatric Pain Management in Nigeria

Author

Ogunyinka,Ibrahim, Yusuff,Kazeem, Erah,Patrick O, Oshikoya,Kazeem, Faponle,Folayemi, Ungo-kore,Hussein, Oreagba,Ibrahim, Yakasai,Ahmed, Idoko,Anthony, Ileoma,Solape, Umar,Aminu, Ogunyinka,Ibrahim, Yusuff,Kazeem, Erah,Patrick O, Oshikoya,Kazeem, Faponle,Folayemi, Ungo-kore,Hussein, Oreagba,Ibrahim, Yakasai,Ahmed, Idoko,Anthony, Ileoma,Solape, and Umar,Aminu

Abstract

ibrahim Ogunyinka,1 Kazeem Yusuff,2 Patrick O Erah,3 Kazeem Oshikoya,4 Folayemi Faponle,5 Hussein Ungo-kore,6 Ibrahim Oreagba,7 Ahmed Yakasai,8 Anthony Idoko,9 Solape Ileoma,10 Aminu Umar1 1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria; 2Department of Clinical Pharmacy and Practice, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 3Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; 4Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria; 5Department of Anaesthesia and Intensive Care Unit, Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria; 6Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria; 7Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria; 8Pharmaplus Nigeria Limited, Kano, Nigeria; 9Directorate of Education and Training, Pharmacists Council of Nigeria, Idu, Abuja, Nigeria; 10Department of Pharmacy, Lagos Island Maternity Hospital, Lagos, NigeriaCorrespondence: ibrahim OgunyinkaDepartment of Clinical Pharmacy and Pharmacy Practice, Usmanu Danfodiyo University Sokoto, Sokoto, PMB 2346, NigeriaTel +234-803-936-3848Email ib1072000@yahoo.com.auPurpose: Community pharmacists (CPs) frequently attend to pediatric patients with pain but limited data exist regarding their knowledge of and attitude to effective management of pediatric pain in Nigeria. Thus, this study aimed to evaluate the knowledge of and attitude to pediatric pain management among CPs in Nigeria.Patients and Methods: A validated and pilot-tested questionnaire, the Community Pharmacists Survey on Pediatric Pain, was administered t

Published
2021

5. Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03707c Click here for additional data file

Author

Song, Zhongshu, Bakeer, Walid, Marshall, James W., Yakasai, Ahmed A., Khalid, Rozida Mohd, Collemare, Jerome, Skellam, Elizabeth, Tharreau, Didier, Lebrun, Marc-Henri, Lazarus, Colin M., Bailey, Andrew M., Simpson, Thomas J., and Cox, Russell J.

Subjects
Chemistry, food and beverages
Abstract

Heterologous expression of key components of the Magnaporthe grisea ACE1 gene cluster produces a potential precursor of cryptic avirulence signalling compounds that induce resistance to M. grisea in rice., The ACE1 and RAP1 genes from the avirulence signalling gene cluster of the rice blast fungus Magnaporthe oryzae were expressed in Aspergillus oryzae and M. oryzae itself. Expression of ACE1 alone produced a polyenyl pyrone (magnaporthepyrone), which is regioselectively epoxidised and hydrolysed to give different diols, 6 and 7, in the two host organisms. Analysis of the three introns present in ACE1 determined that A. oryzae does not process intron 2 correctly, while M. oryzae processes all introns correctly in both appressoria and mycelia. Co-expression of ACE1 and RAP1 in A. oryzae produced an amide 8 which is similar to the PKS-NRPS derived backbone of the cytochalasans. Biological testing on rice leaves showed that neither the diols 6 and 7, nor amide 8 was responsible for the observed ACE1 mediated avirulence, however, gene cluster analysis suggests that the true avirulence signalling compound may be a tyrosine-derived cytochalasan compound.

Published
2015

6. Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana

Author

Halo, Laura M., Heneghan, Mary N., Yakasai, Ahmed A., Zhongshu Song, Williams, Katherine, Bailey, Andrew M., Cox, Russell J., Lazarus, Colin M., and Simpson, Thomas J.

Subjects
Cytochrome P-450 -- Chemical properties, Gene expression -- Analysis, Hydroxylation -- Analysis, Oxidation-reduction reaction -- Analysis, Chemistry
Abstract

Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauvria bassiana are examined by a combination of gene knockout, antisense RNA and gene coexpression studies. ORF2 has encoded an unusual cytochrome P450 monooxygenase needed for the selective N-hydroxylation of the 2-pyridone that is incapable of N-hydroxylation of acyltetramic acids.

Published
2008

7. Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae

Author

Song, Zhongshu, Bakeer, Walid, Marshall, James W., Yakasai, Ahmed A., Mohd Khalid, Rozida, Collemare, Jérôme, Skellam, Elizabeth, Tharreau, Didier, Lebrun, Marc-Henri, Lazarus, Colin M., Bailey, Andrew M., Simpson, Thomas J., Cox, Russel J., Song, Zhongshu, Bakeer, Walid, Marshall, James W., Yakasai, Ahmed A., Mohd Khalid, Rozida, Collemare, Jérôme, Skellam, Elizabeth, Tharreau, Didier, Lebrun, Marc-Henri, Lazarus, Colin M., Bailey, Andrew M., Simpson, Thomas J., and Cox, Russel J.

Abstract

The ACE1 and RAP1 genes from the avirulence signalling gene cluster of the rice blast fungus Magnaporthe oryzae were expressed in Aspergillus oryzae and M. oryzae itself. Expression of ACE1 alone produced a polyenyl pyrone (magnaporthepyrone), which is regioselectively epoxidised and hydrolysed to give different diols, 6 and 7, in the two host organisms. Analysis of the three introns present in ACE1 determined that A. oryzae does not process intron 2 correctly, while M. oryzae processes all introns correctly in both appressoria and mycelia. Co-expression of ACE1 and RAP1 in A. oryzae produced an amide 8 which is similar to the PKS-NRPS derived backbone of the cytochalasans. Biological testing on rice leaves showed that neither the diols 6 and 7, nor amide 8 was responsible for the observed ACE1 mediated avirulence, however, gene cluster analysis suggests that the true avirulence signalling compound may be a tyrosine-derived cytochalasan compound.

Published
2015

8. Pattern of in-patient neurologic review: An experience from a Tertiary Hospital North-Western Nigeria.

Author

Ibrahim, Aliyu, Femi Owolabi, Lukman, Maiyaki Musa, Baba, Aliyu, Salisu, Rabiu, Musbahu, and Maifada Yakasai, Ahmed

Subjects
NEUROLOGY, NEUROLOGISTS, PHYSICIANS, PSYCHIATRISTS, MEDICAL personnel
Abstract

Copyright of Annals of African Medicine is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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12. The programming role of trans-acting enoyl reductases during the biosynthesis of highly reduced fungal polyketides

Author

Heneghan, Mary N., primary, Yakasai, Ahmed A., additional, Williams, Katherine, additional, Kadir, Khomaizon A., additional, Wasil, Zahida, additional, Bakeer, Walid, additional, Fisch, Katja M., additional, Bailey, Andrew M., additional, Simpson, Thomas J., additional, Cox, Russell J., additional, and Lazarus, Colin M., additional

Published
2011
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14. Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

Author

Halo, Laura M., primary, Marshall, James W., additional, Yakasai, Ahmed A., additional, Song, Zhongshu, additional, Butts, Craig P., additional, Crump, Matthew P., additional, Heneghan, Mary, additional, Bailey, Andrew M., additional, Simpson, Thomas J., additional, Lazarus, Colin. M., additional, and Cox, Russell J., additional

Published
2008
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