17 results on '"Ya Nan Lv"'
Search Results
2. An MRI radiomics-based model for the prediction of invasion of the lymphovascular space in patients with cervical cancer
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Nan-Nan Ma, Tao Wang, Ya-Nan Lv, and Shao-Dong Li
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MRI ,radiomics ,lymphovascular space invasion ,cervical cancer ,prediction ,model ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundCervical cancer (CC) remains the second leading cause of cancer-related death in women, and the ability to accurately anticipate the presence or absence of lymphovascular space invasion (LVSI) is critical to maintaining optimal patient outcomes. The objective of this study was to establish and verify an MRI radiomics-based model to predict the status of LVSI in patients with operable CC.MethodsThe current study performed a retrospective analysis, with 86 patients in the training cohort and 38 patients in the testing group, specifically focusing on patients with CC. The radiomics feature extraction process included ADC, T2WI-SPAIR, and T2WI sequences. The training group data were used for the initial radionics-based model building, and the model predictive performance was subsequently validated using data from patients recruited in the experimental group.ResultsThe development of the radiomics scoring model has been completed with 17 selected features. The study found several risk factors associated with LVSI. These risk factors included moderate tumor differentiation (P = 0.005), poor tumor differentiation (P = 0.001), and elevated combined sequence-based radiomics scores (P = 0.001). Radiomics scores based on predictive model, combined sequences, ADC, T2WI-SPAIR, and T2WI exhibited AUCs of 0.897, 0.839, 0.815, 0.698, and 0.739 in the training cohort, respectively, with corresponding testing cohort values of 0.833, 0.833, 0.683, 0.692, and 0.725. Excellent consistency was shown by the calibration curve analysis, which showed a higher degree of agreement between the actual and anticipated LVSI status. Moreover, the decision curve analysis outcomes demonstrated the medical application of this prediction model.ConclusionThis investigation indicated that the MRI radiomics model was successfully developed and validated to predict operable CC patient LVSI status, attaining high overall diagnostic accuracy. However, further external validation and more deeper analysis on a larger sample size are still needed.
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- 2024
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3. Systematic review and meta-analysis of low-dose CT-driven biopsy for pulmonary nodules
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Ying Zhao, Kun Xiong, and Ya-Nan Lv
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computed tomography ,biopsy ,pulmonary nodule ,low-dose ,Medicine - Published
- 2023
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4. Preoperative localization for lung nodules: a meta-analysis of bronchoscopic versus computed tomography guidance
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Jiang Du, Yu-Fei Fu, and Ya-Nan Lv
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computed tomography ,bronchoscopic ,localization ,lung nodule ,Medicine - Published
- 2022
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5. Sleep deficiency promotes Alzheimer's disease development and progression
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Ya-Nan Lv, Yu Cui, Bo Zhang, and Shu-Ming Huang
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sleep deficiency ,Alzheimer's disease ,β-amyloid protein ,tau protein ,oxidative stress ,inflammatory response ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Sleep disorders are a common health problem in modern society. Long-term sleep deficiency increases the risk for Alzheimer's disease. However, the exact mechanisms by which sleep deficiency affects Alzheimer's disease remain unclear. Therefore, we reviewed the relevant studies and investigated the role of sleep deprivation in Alzheimer's disease pathogenesis. Sleep deficiency was found to be associated with oxidative stress, β-amyloid protein deposition, tau hyperphosphorylation, and neuroinflammation, which are known to increase the risk for Alzheimer's disease. In addition, insufficient sleep also increases glucocorticoid levels, decreases brain-derived neurotrophic factor levels, and reduces the number of synapses in the central nervous system. These factors also promote Alzheimer's disease development and progression. The present study showed that a growing body of evidence supports an association between sleep disturbances and Alzheimer's disease. It discusses the role of sleep insufficiency in Alzheimer's disease pathogenesis, which may provide a theoretical basis for effective treatment and prevention strategies.
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- 2022
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6. Mechanism of high temperature reduction on iron carbide preparation with low-grade siderite
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Dong Chen, Ya-nan Lv, Wei Zhao, Fei-bao Wu, and Wei-ang Ying
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Mechanics of Materials ,Materials Chemistry ,Metals and Alloys - Published
- 2022
7. Selection of Reference Genes for Normalization of Gene Expression in Thermobia domestica (Insecta: Zygentoma: Lepismatidae)
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Yu Bai, Ya-Nan Lv, Mei Zeng, Pei-Yao Jia, Hu-Na Lu, Yi-Bo Zhu, Sheng Li, Ying-Ying Cui, and Yun-Xia Luan
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Thermobia domestica ,reference genes ,expression stability ,quantitative real-time PCR ,RNA interference ,Genetics ,QH426-470 - Abstract
Zygentoma occupies a key evolutionary position for understanding the evolution of insect metamorphosis but has received little attention in terms of genetic analysis. To develop functional genomic studies in this insect, we evaluated five candidate internal reference genes for quantitative RT-PCR (qPCR) studies from Thermobia domestica, a representative species of Zygentoma, including Actin 5C (Actin5C), Elongation factor-1 alpha (EF1A), Ribosome protein S26 (RPS26), Ribosome protein L32 (RPL32), and Superoxide dismutase 2 (SOD2), at different developmental stages, in various body parts, and under dsRNA microinjection and starvation stresses, using four algorithms (delta Ct, geNorm, NormFinder and BestKeeper) and a comparative algorithm (RefFinder). Specific suitable reference genes were recommended across specific experimental conditions, and the combination of RPS26 and RPL32 was appropriate for all tested samples. Employing our selected reference gene combination, we investigated the gene expression pattern of Myoglianin (Myo), a crucial gene-regulating insect metamorphosis, in ametabolous T. domestica, and demonstrated the efficiency of RNA interference (RNAi) in firebrat nymphs. This study provides a basis for reliable quantitative studies of genes and greatly benefits evolutionary and functional genomics studies in Zygentoma.
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- 2020
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8. Saturated absorption spectroscopy of HD at 76 K
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Qian-Hao Liu, Ya-Nan Lv, Chang-Ling Zou, Cun-Feng Cheng, and Shui-Ming Hu
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- 2022
9. Selection of Reference Genes for Normalization of Gene Expression in Thermobia domestica (Insecta: Zygentoma: Lepismatidae)
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Pei-Yao Jia, Hu-Na Lu, Yu Bai, Ying-Ying Cui, Yun-Xia Luan, Ya-Nan Lv, Sheng Li, Mei Zeng, and Yi-Bo Zhu
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0301 basic medicine ,Genetics ,biology ,lcsh:QH426-470 ,Lepismatidae ,reference genes ,Thermobia domestica ,biology.organism_classification ,RNA interference ,03 medical and health sciences ,lcsh:Genetics ,030104 developmental biology ,0302 clinical medicine ,expression stability ,Reference genes ,Gene expression ,Thermobia ,quantitative real-time PCR ,Firebrat ,Functional genomics ,Gene ,030217 neurology & neurosurgery ,Genetics (clinical) - Abstract
Zygentoma occupies a key evolutionary position for understanding the evolution of insect metamorphosis but has received little attention in terms of genetic analysis. To develop functional genomic studies in this insect, we evaluated five candidate internal reference genes for quantitative RT-PCR (qPCR) studies from Thermobia domestica, a representative species of Zygentoma, including Actin 5C (Actin5C), Elongation factor-1 alpha (EF1A), Ribosome protein S26 (RPS26), Ribosome protein L32 (RPL32), and Superoxide dismutase 2 (SOD2), at different developmental stages, in various body parts, and under dsRNA microinjection and starvation stresses, using four algorithms (delta Ct, geNorm, NormFinder and BestKeeper) and a comparative algorithm (RefFinder). Specific suitable reference genes were recommended across specific experimental conditions, and the combination of RPS26 and RPL32 was appropriate for all tested samples. Employing our selected reference gene combination, we investigated the gene expression pattern of Myoglianin (Myo), a crucial gene-regulating insect metamorphosis, in ametabolous T. domestica, and demonstrated the efficiency of RNA interference (RNAi) in firebrat nymphs. This study provides a basis for reliable quantitative studies of genes and greatly benefits evolutionary and functional genomics studies in Zygentoma.
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- 2021
10. Rabi resonance in coherent population trapping: microwave mixing scheme
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Chang-Lin Zou, Ning Ru, Jifeng Qu, Songbai Kang, Ya-Nan Lv, Xiaochi Liu, and Junyi Duan
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Condensed Matter::Quantum Gases ,Physics ,education.field_of_study ,Field (physics) ,business.industry ,Population ,Resonance ,02 engineering and technology ,Optical field ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,010309 optics ,Optics ,0103 physical sciences ,Physics::Atomic Physics ,Atomic physics ,0210 nano-technology ,education ,business ,Microwave ,Mixing (physics) ,Rabi frequency ,Coherence (physics) - Abstract
Coherent population trapping (CPT) resonance signals have promise in a wide range of applications involving precision sensing. Generally, the CPT phenomenon occurs in a three-level Λ system with a bichromatic phase-coherent light fields. We theoretically and experimentally studied an Rb vapor-cell-based atomic system involving bichromatic CPT optical fields and an external microwave (MW) field simultaneously. In such a mixing scheme, the coherence of the ground states could be controlled either by the Rabi frequency of the microwave field or by the relative phase between the optical fields and the MW field. Moreover, we investigated the Rabi resonance in this mixing scheme. The Rabi frequency of the MW field can be measured SI (International System of Units)-traceably based on the Rabi resonance lineshape, and thus holds the potential to realize intensity stabilization of the optical field in this system. Simple theoretical models and numerical calculations are also presented to explain the experimental results. There is scope to use the proposed technique in future development of SI-traceable optical field strength standards.
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- 2021
11. Update on urine as a biomarker in cancer: a necessary review of an old story
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Xiao Jian Zhang, Yue Yu Bai, Zi Jing Zhang, Wei Zhang, Shen Yan Chao, Ya Nan Lv, Jian Zhao, Jing Jie Yao, and Su Juan Chen
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0301 basic medicine ,medicine.medical_specialty ,Urinary system ,Urine ,Urinalysis ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Genetics ,medicine ,Biomarkers, Tumor ,Humans ,Precision Medicine ,Intensive care medicine ,Molecular Biology ,Early Detection of Cancer ,business.industry ,Liquid Biopsy ,Cancer ,Precision medicine ,medicine.disease ,Urinary biomarkers ,Prognosis ,Molecular biomarkers ,030104 developmental biology ,Urine biomarkers ,030220 oncology & carcinogenesis ,Molecular Medicine ,Biomarker (medicine) ,business - Abstract
Introduction: Cancer causes thousands of deaths worldwide each year. Therefore, monitoring of health status and the early diagnosis of cancer using noninvasive assays, such as the analysis of molecular biomarkers in urine, is essential. However, effective biomarkers for early diagnosis of cancer have not been established in many types of cancer.Areas covered: In this review, we discuss recent findings with regard to the use of urine composition as a biomarker in eleven types of cancer. We also highlight the use of urine biomarkers for improving early diagnosis.Expert opinion: Urinary biomarkers have been applied for clinical application of early diagnosis. The main limitation is a lack of integrated approaches for identification of new biomarkers in most cancer. The utilization of urinary biomarker detection will be promoted by improved detection methods and new data from different types of cancers. With the development of precision medicine, urinary biomarkers will play an increasingly important clinical role. Future early diagnosis would benefit from changes in the utilization of urinary biomarkers.
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- 2020
12. miR‑144 suppresses proliferation and induces apoptosis of osteosarcoma cells via direct regulation of mTOR expression
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Tie‑Hui Zhang, Yuan‑Fei Ren, Yan‑Tao Zhao, Sheng Zhong, and Ya‑Nan Lv
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0301 basic medicine ,Cancer Research ,Oncogene ,Cell ,Articles ,Biology ,Cell cycle ,medicine.disease ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,Apoptosis ,Cell culture ,030220 oncology & carcinogenesis ,microRNA ,medicine ,Osteosarcoma ,PI3K/AKT/mTOR pathway - Abstract
Studied as a type of tumor suppressor, microRNA (miR) performs an important role in growth and apoptosis of various human carcinomas. However, the effects of miR-l44 on osteosarcoma growth and apoptosis, as well as possible underlying mechanisms, remain unclear. The present study investigated the expression of miR-144 in osteosarcoma MG-63 and U-2 OS cell lines compared with osteoblast cells. In order to elucidate the effects of miR-144 on osteosarcoma, miR-144 was upregulated in MG-63 and U-2 OS cells by transfecting chemically synthesized miR-144 mimics. Bioinformatics analysis of potential miR-144 target genes was performed using TargetScanHuman 7.0 and confirmed by luciferase assay. This analysis identified mammalian target of rapamycin (mTOR) as a target of miR-144. The present results indicated that the overexpression of miR-144 may significantly inhibit proliferation and promote apoptosis of MG-63 and U-2 cells compared with scramble control. Furthermore, the effects of miR-144 on osteosarcoma were associated with the mTOR signaling pathway via directly targeting the 3' untranslated region of mTOR mRNA, resulting in a decrease in the level of mTOR protein. In summary, miR-144 was demonstrated to act as a tumor suppressor, which inhibits proliferation and promotes apoptosis of osteosarcoma cell lines. In addition, this effect was mediated by direct targeting on mTOR following inhibition of the mTOR signaling pathway. The present study suggested that miR-144 may be a candidate for the gene therapy of osteosarcoma.
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- 2017
13. Synthesis of Stable Colloidal Suspension of Graphene
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Ya Nan Lv, Hui Zhu, You Yu Zhang, Haitao Li, Hui Ping Liu, Cheng-an Tao, and Jian Fang Wang
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Materials science ,Graphene ,Oxide ,Nanotechnology ,Graphite oxide ,General Medicine ,law.invention ,symbols.namesake ,chemistry.chemical_compound ,Colloid ,Chemical engineering ,chemistry ,law ,symbols ,Suspension (vehicle) ,Raman spectroscopy ,Deoxygenation ,Graphene oxide paper - Abstract
In this article, graphite oxide was prepared via Hummers method, then reduced by L-ascorbic acid to obtain colloidal suspension of graphene. The resultant graphene was characterized by FT-IR, UV-vis, Raman, XRD, AFM, TEM in detail, and it was found that the the sp2 domain of graphene oxide is restored efficiently, the suspension is very stable and most of the graphene is single-layer. Compared to hydrazine hydrate, L-ascorbic acid has higher deoxygenation efficiency and inclines to gain few-layer graphene and its stable suspensions.
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- 2013
14. Fabrication of Scattering Spheres-Embedding Three-Dimensional Ordered Macroporous Titania and Application in Dye-Sensitized Photoanode
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Guangtao Li, Ya Nan Lv, Yin Long, Jian Fang Wang, and Cheng-an Tao
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chemistry.chemical_classification ,Anatase ,Materials science ,Scattering ,Scanning electron microscope ,General Engineering ,Nanoparticle ,Nanotechnology ,Polymer ,Colloidal crystal ,Light scattering ,chemistry ,Chemical engineering ,Transmission electron microscopy - Abstract
Scattering spheres-embedding three-dimensional ordered macroporous (3DOM) titania(TiO2) was fabricated, by the route of colloidal spheres self-assembly, infiltration and template removal. The procedures of 3DOM structure preparation were characterized by transmission electron microscope (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD). The silica@PMMA core-shell spheres were prepared and self-assembled into colloidal crystal template. Solid material was deposited in the colloidal crystal template by spin-coating of titania nanoparticle dispersions. Subsequently, the samples were heated to 400 °C to form anatase TiO2and to remove the polymer of template, which resulted in macroporous structure with a silica sphere in each lattice pore. The conventional TiO2film, 3DOM TiO2photoanodes were also fabricated. It was found that SiO2-embedding 3DOM photoanode has the higher photocurrent efficiency than both of TiO2 film and 3DOM, because there are scattering spheres in its lattice pores which enhance the light scattering and improve the light harvest of the dye.
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- 2012
15. The Preparation of Graphene via Thermal Reduction Method
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Jian Fang Wang, Hui Zhu, Cheng-an Tao, Ya Nan Lv, and Yin Long
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Materials science ,Graphene ,General Engineering ,Oxide ,Nanotechnology ,Reduction methods ,law.invention ,Smooth surface ,Reduction (complexity) ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,Thermal ,Thermal methods ,Graphene oxide paper - Abstract
In this paper, the graphene oxide reducing by photochemical-thermal reduction and high-temperature thermal reduction was studied to get qualified graphene and avoid the re-aggregation. The results show that graphene obtained by both of the two reduction methods all maintained the original well-layered morphology of the graphene oxide. The graphene had smooth surface and high quality as completely reduced by high-temperature thermal method. However, the reduction the photochemical-thermal reaction was not sufficient and caused many vesicles on the graphene surface due to the low temperature and the lack of reaction time.
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- 2012
16. How Graphene Layers Depend on Drying Methods of Graphene Oxide
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Lin Xia, Yin Long, Hui Zhu, Ya Nan Lv, Jian Fang Wang, and Cheng-an Tao
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Materials science ,Graphene ,Graphene foam ,General Engineering ,Oxide ,Graphite oxide ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Thin film ,Composite material ,Layer (electronics) ,Aerographene ,Graphene oxide paper - Abstract
Graphite oxide is of great importance in preparing graphene, the average layer of graphene depends on that of graphene oxide in some extent. In this paper, we prepared graphite oxide via H3PO4/H2SO4mixed acid, then which were dried by vacuum drying in a freezer dryer and drying oven respectively, the graphite oxide powder and thin film were obtained correspondingly. After dispersing the above two forms of graphite oxide in water by shaking, stirring or supersonic wave, they were reduced in the same condition. According to the XRD, AFM results, vacuum freeze-drying was inclined to gain few-lay graphene.
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- 2012
17. Preparation and Characterization of Graphene by the Oxidation Reduction Method
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Cheng-an Tao, Hui Zhu, Lin Xia, Jian Fang Wang, Ya Nan Lv, and Yin Long
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Materials science ,Graphene ,Scanning electron microscope ,Inorganic chemistry ,Intercalation (chemistry) ,General Engineering ,Graphite oxide ,law.invention ,symbols.namesake ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,law ,symbols ,Graphite ,Raman spectroscopy ,Hydrate ,Graphene oxide paper - Abstract
We prepared graphite oxide (GO) from natural graphite by the modified Hummers method. Then graphene was prepared by ultrasonically dispersing GO in the presence of hydrazine hydrate. The samples were characterized by FTIR, Raman, Scanning electron microscope (SEM) and Transmission electron microscope (TEM). The results suggest that the graphite is oxidized to covalent bond-type graphite intercalation compounds with various oxygen functional groups (C=O, C-OH, -COOH and C-O-C). Results show that the functional groups on graphite oxide surface are mostly removed by hydrazine hydrate and graphene presents translucent slide with curly edge.
- Published
- 2012
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