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Update on urine as a biomarker in cancer: a necessary review of an old story
- Source :
- Expert review of molecular diagnostics. 20(5)
- Publication Year :
- 2020
-
Abstract
- Introduction: Cancer causes thousands of deaths worldwide each year. Therefore, monitoring of health status and the early diagnosis of cancer using noninvasive assays, such as the analysis of molecular biomarkers in urine, is essential. However, effective biomarkers for early diagnosis of cancer have not been established in many types of cancer.Areas covered: In this review, we discuss recent findings with regard to the use of urine composition as a biomarker in eleven types of cancer. We also highlight the use of urine biomarkers for improving early diagnosis.Expert opinion: Urinary biomarkers have been applied for clinical application of early diagnosis. The main limitation is a lack of integrated approaches for identification of new biomarkers in most cancer. The utilization of urinary biomarker detection will be promoted by improved detection methods and new data from different types of cancers. With the development of precision medicine, urinary biomarkers will play an increasingly important clinical role. Future early diagnosis would benefit from changes in the utilization of urinary biomarkers.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Urinary system
Urine
Urinalysis
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Neoplasms
Genetics
medicine
Biomarkers, Tumor
Humans
Precision Medicine
Intensive care medicine
Molecular Biology
Early Detection of Cancer
business.industry
Liquid Biopsy
Cancer
Precision medicine
medicine.disease
Urinary biomarkers
Prognosis
Molecular biomarkers
030104 developmental biology
Urine biomarkers
030220 oncology & carcinogenesis
Molecular Medicine
Biomarker (medicine)
business
Subjects
Details
- ISSN :
- 17448352
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Expert review of molecular diagnostics
- Accession number :
- edsair.doi.dedup.....22e5e9735ed66ecb01c1fe25072442da