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Artificial quartz dust exposure may cause associated pneumoconiosis. From November 2019 to July 2020, a total of 27 cases of silicosis associated with artificial quartz stone manufacturers were diagnosed and treated in the Occupational disease Department of Suzhou Fifth People's Hospital. The average age of onset was (46.8±6.6) years, and the average working age of dust exposure was (5.7±1.7) years.The main feature of high KV chest radiography is P/S shadow with strip shadow. CT imaging findings showed diffuse small nodules and ground glass shadows with band shadows. The lesions were mainly distributed in the upper lung, accompanied by pleural thickening, lymphadenopathy and calcification. The pulmonary function impairment was mainly mild restrictive ventilation disorder, and the bronchial mucosa longitudinal plica was the main manifestation under tracheoscopy. The age of silicosis of workers in artificial quartz stone production enterprises is younger, the working age of dust exposure is short, the lung function and bronchial mucosa have a certain degree of damage, and effective preventive measures should be taken in time.人造石英石粉尘暴露有可能引起相关性尘肺。2019年11月至2020年7月苏州市第五人民医院职业病科共诊治27例人造石英石生产企业相关性矽肺，患者平均发病年龄为（46.8±6.6）岁，平均接尘工龄为（5.7±1.7）年。高KV胸片以P/S影伴条索影为主，CT影像学表现均有弥漫性小结节影和磨玻璃影伴条索影，病灶分布以双上肺为主，伴有胸膜增厚、淋巴结肿大、钙化，肺功能损害以轻度限制性通气障碍为主，气管镜下表现以支气管黏膜纵行皱襞为主。人造石英石生产企业工人矽肺发病年龄较轻、接尘工龄短、肺功能、支气管黏膜有一定程度的损害，应及时采取有效的预防措施。.

患儿 男，3岁10月龄，因“间歇发热2周伴咳嗽、气促”入上海交通大学医学院附属仁济医院（南部院区）定点医院隔离病房。患儿病初发热，确诊为新型冠状病毒肺炎（简称新冠肺炎），热退2 d再次持续高热3 d伴气促、吸气性凹陷，胸部CT示右肺下叶片状密度影，诊断“重型新冠肺炎”，行支气管镜肺泡灌洗，宏基因组病原检测确诊为混合肺炎支原体感染，治疗好转出院。提示临床医生诊治重型新冠肺炎时需警惕混合感染。.

An approach is presented for solving plate bending problems using a high-order infinite element method (IEM) based on Mindlin–Reissner plate theory. In the proposed approach, the computational domain is partitioned into multiple layers of geometrically similar virtual elements which use only the data of the boundary nodes. Based on the similarity, a reduction process is developed to eliminate virtual elements and overcome the problem that the conventional reduction process cannot be directly applied. Several examples of plate bending problems with complicated geometries are reported to illustrate the applicability of the proposed approach and the results are compared with those obtained using ABAQUS software. Finally, the bending behavior of a rectangular plate with a central crack is analyzed to demonstrate that the stress intensity factor (SIF) obtained using the high-order PIEM converges faster and closer than low-order PIEM to the analytical solution.

Metabolic-associated fatty liver disease is a hepatic manifestation of systemic metabolic disorders, with a high prevalence. Moreover, it often coexists and evidently interacts with liver injury caused by a variety of viral infections in association with specific bacterial or fungal infectious diseases, and thus unitedly affect the intra-and extrahepatic diseases clinical outcome. The mutual effects, natural process, and extrahepatic manifestations of the two diseases combined coexistence are now elaborated here.代谢相关脂肪性肝病是全身性代谢紊乱的肝脏表现，其患病率高，除经常与多种病毒感染导致的肝损害共存并相互作用外，还与特定细菌或真菌感染性疾病存在关联，共同影响肝内和肝外临床结局。现对二者合并共存时的相互影响、肝病自然进程和疾病肝外表现等做一阐述。.

Aims To increase enduracidin production in Streptomyces fungicidicus ATCC 31731 by overexpressing positive regulators in enduracidin biosynthesis. Methods and results Genes orf22 and orf42 were knocked out by in-frame deletion based on CRISPR/Cas9 strategy, while the orf41 gene was inactivated by replacing it with the apramycin resistance gene cassette aac(3)IV using a fast screening blue/white system. The integrative plasmid pSET152ermE was used for the overexpression of orf22, orf41 and orf42 individually. The constructed plasmids were transformed into wild-type strain Streptomyces fungicidicus ATCC 31731. Three gene inactivation mutants Δorf22, Δorf41 and Δorf42 and three recombinant strains overexpressing orf22, orf41 and orf42 were all fermented and the enduracidin production of each strain was detected and compared by HPLC analysis. Two resulting engineered strains were generated through overexpression of gene orf22 and orf42 in Streptomyces fungicidicus, respectively, and in these strains the enduracidins titres were increased by approximately 4·0-fold and 2·3-fold higher than that of the wild-type strain. Conclusions The functions of three regulatory genes orf22, orf41 and orf42 in the enduracidin gene cluster in Streptomyces fungicidicus ATCC 31731 were examined. The orf22 gene, encoding a SARP family protein, was proposed to act in a positive manner. The proteins encoded by genes orf41 and orf42 were proposed to compose a two-component regulation system, in which the response protein Orf41 was characterized as a repressor, and the kinase Orf42 was shown to be an activator. The production of enduracidins was improved considerably by overexpression of the two positive regulatory genes orf22 and orf42 respectively. Significance and impact of the study The production of enduracidins was successfully improved by manipulating the regulatory genes involving in enduracidin biosynthesis, providing an efficient approach to improve enduracidin production further for fermentation industry and synthetic biological research.

An approach is presented for solving membrane vibration problems using an integrated scheme consisting of the Craig-Bampton (CB) reduction technique and a 2D dynamic infinite element modeling (DIEM) method. In the proposed CB-DIEM scheme, the substructure domain is partitioned into multiple layers of geometrically-similar infinite elements (IEs) which use only the data of the boundary nodes. A convergence criterion based on the first invariant of the DIEM mass matrix is used to determine the optimal parameters of the CB-DIEM scheme, namely the proportionality ratio and number of layers in the DIEM partitioning process and the number of retained frequency modes in the CB reduction method. Furthermore, in implementing the CB method, the inversion of the global stiffness matrix is calculated using only the stiffness matrix of the first element layer. Having reduced the DIEM model, a coupled DIE-FE algorithm is employed to model the dynamic problems of the full structure, which removes the respective methods disadvantages while keeping their advantages. The validity and performance of the proposed CB-DIEM method are investigated by means of three illustrative problems.

极简式经导管主动脉瓣置换术（TAVR）采用局部麻醉联合镇静，术中采用经胸超声心动图，通过股动脉入路开展的简化流程的TAVR手术。患者术后恢复快，大部分患者术后第2天即可出院。该文报道1例因外科生物瓣衰败，行极简式TAVR治疗的重度主动脉瓣狭窄病例。术后患者恢复良好，4 h即可下地行走，第2天出院。术后随访30 d，患者无明显不适。.

手臂振动病是长期使用振动工具引起的以末梢循环障碍为主的全身性疾病，可引起手臂骨关节-肌肉的损伤，被认为是最具致残性的疾病之一，典型表现为振动性白指。职业性手臂振动病发病机制尚未阐明，目前无特效治疗药物，确诊患者应及时调离手传振动作业岗位，根据病情需要进行扩张血管、营养神经、物理和运动疗法等综合治疗。本文对3例手臂振动病患者的临床资料进行分析，以提高政府、企业和员工的重视。.

Recently, advanced planning and scheduling system (APS) has drawn wide attention. In this paper, we proposed an APS system that fully coordinates human management, equipment management, material management, logistics management, process management. It covers these five areas to make production plans and achieve higher levels of lean production management goals, simultaneous and parallelize planning, better efficiency, process optimization and closed-loop management. It performs better global optimization by coordinating all the sub-components rather than using only MES, WMS or PCS.

Collaborative framework in manufacturing has drawn wide attention. There exist huge methods and discussions on this topic under designing, supply chain, and manufacturing. With a motivation to improve system efficiency and give higher capital turnover, this work provides the following two parts. Firstly, this work designs a collaborative framework and methods in the designing, supply chain, and manufacturing. Next, this work plans potential collaboration methods with any two of those three components and gives illustrations. The result of this work, the six designed framework and methods aims to potentially achieve the intelligent and automated production logistics system, the entire process information management, fast capital turnover, transparent cost, accurate, smart manufacturing system, and the intelligent interconnection of equipment and human-machine systems with the least investment, quick output, and large output.

The collaborative multi-process and multiservice integrated construction industry management service system framework based on big data proposed in this study, focuses on the big data intelligent decision-making service of construction industry based on integrated management, builds a big data intelligent decision service support platform for construction industry based on integrated management, develops multi-process integrated management service function module of construction industry, innovates various service models. It develops modules of services covering the whole process of construction from four aspects of building collaborative design management, building supply chain management, building project collaborative management, and hardcover personalization. It also provides innovated, efficient, networked and personalized services for various roles in the construction industry, such as mobile-oriented service for an engineer, design selection decision service for the designer, supply chain collaborative management service for the supplier and others.

Background: We examined the ability of a biopsy-based 22-marker genomic classifier (GC) to predict for distant metastases after radiation and a median of 6 months of androgen deprivation therapy (ADT). Methods: We studied 100 patients with intermediate-risk (55%) and high-risk (45%) prostate cancer who received definitive radiation plus a median of 6 months of ADT (range 3–39 months) from 2001–2013 at a single center and had available biopsy tissue. Six to ten 4 micron sections of the needle biopsy core with the highest Gleason score and percentage of tumor involvement were macrodissected for RNA extraction. GC scores (range, 0.04–0.92) were determined. The primary end point of the study was time to distant metastasis. Median follow-up was 5.1 years. There were 18 metastases during the study period. Results: On univariable analysis (UVA), each 0.1 unit increase in GC score was significantly associated with time to distant metastasis (hazard ratio: 1.40 (1.10–1.84), P=0.006) and remained significant after adjusting for clinical variables on multivariable analysis (MVA) (adjusted hazard ratio: 1.36 (1.04–1.83), P=0.024). The c-index for 5-year distant metastasis was 0.45 (95% confidence interval: 0.27–0.64) for Cancer of the Prostate Risk Assessment score, 0.63 (0.40–0.78) for National Comprehensive Cancer Network (NCCN) risk groups, and 0.76 (0.57–0.89) for the GC score. Using pre-specified GC risk categories, the cumulative incidence of metastasis for GC>0.6 reached 20% at 5 years after radiation (P=0.02). Conclusions: We believe this is the first demonstration of the ability of the biopsy-based GC score to predict for distant metastases after definitive radiation and ADT for intermediate- and high-risk prostate cancer. Patients with the highest GC risk (GC>0.6) had high rates of metastasis despite multi-modal therapy suggesting that they could potentially be candidates for treatment intensification and/or enrollment in clinical trials of novel therapy.

Three commercial bio-aid samples have shown good troubleshooting capabilities earlier during several biological wastewaters processing, but their microbial contents were still unclear. This study was aimed to assess eubacteria contents for the three bio-aids based on sequence comparisons of 16S ribosomal deoxyribonucleic acid (rDNA). Majority of target 16S rDNA sequences of bacteria within or cultured from bio-aids were obtained via pyrosequencing-based approach, and few sequences were from isolation- or cloning-sequencing approaches. Results showed that a total of 8114, 2327, and 5402 sequences were retrieved from pyrosequencing-based methods for the three bio-aids, respectively, which were affiliated with 100, 80, and 59 bacterial species based on sequence comparison using Ribosome Data Project (RDP) Classifier and Basic Local Alignment Search Tool (BLAST). Target sequences matched Bacillus sp., Enterococcus sp., and Clostridium sp. of Firmicutes phylum were the most abundant for the bio-aids, while some sequences identical to bacteria of phyla Actinobacteria, Bacteroidetes, Chloroflexi, Cyanobacteria, and Proteobacteria were also found. Additionally, most of sequences from the isolation- or cloning-sequencing-based methods were not retrieved by the pyrosequencing-based methods. Culture media appeared to potentially select several bacteria species within phyla Firmicutes and/or Proteobacteria, but sequences from the culture-based methods did fulfill some absences for the uncultured method. Based on principal coordinate analysis, bacteria community structures of the three bio-aids were different. This study provided insights into bacteria contents for the three bio-aids as fundamental information in attempts for future selection or formulation of suitable bio-aids for solving various troubles during wastewater biological processing.

A novel infinite element method (IEM) is presented in this paper for solving plate vibration problems. In the proposed IEM, the substructure domain is partitioned into multiple layers of geometrically similar finite elements which use only the data of the boundary nodes. A convergence criterion based on the trace of the mass matrix is ​​used to determine the number of layers in the IE model partitioning process. Furthermore, in implementing the Craig-Bampton (CB) reduction method, the inversion of the global stiffness matrix is calculated using only the stiffness matrix of the first element layer. The validity and performance of the proposed method are investigated by means of four illustrative problems. The first example considers the case of a simple clamped rectangular plate. It is observed that the IEM results are in good agreement with the theoretical results for all six natural frequencies. The second example considers the frequency response of a clamped rectangular plate with a crack. The main feature of IEM is that a very fine and good quality virtual mesh can be created around the crack tip. The third and fourth examples consider the natural frequency of a multiple point supported plate and a perforated plate, respectively. The results are obtained just need to adjust the reference point or boundary nodes. The parametric analyses for various geometric profiles are easy to be conducted using these numerical techniques. In general, the results presented in this study confirm that the proposed IEM algorithm provides a fast, direct and accurate means of simulating the dynamic response of various plate structures.

Proactive personality scale, psychological capital questionnaire and employee well-being questionnaire are adopted in the research, and employees are investigated through network questionnaire. Data are analyzed for exploring the relationship between proactive personality and employee wellbeing as well as the mediating effect of psychological capital. The result showed that employee proactive personality can be applied for significant forward prediction of employee wellbeing and psychological capital; psychological capital can be applied for significant forward prediction of employee wellbeing; psychological capital has complete mediating effect between proactive personality and employee well-being.

We obtained the first full-length genome sequence of canine bocavirus 2 (CBoV2) from the faeces of a healthy dog in Guangzhou city, Guangdong province, mainland China. The genome of GZHD15 consisted of 5059 nucleotides. Sequence analysis suggested that GZHD15 was close to a previously circulated Hong Kong isolate.

Background How the assist parameters affect synchronization and inspiratory workload in proportional assist ventilation (PAV) remains unknown. Purpose This bench study aimed to optimize the PAV parameters by evaluating their effects on patient-ventilator synchrony and work of breathing (WOB) in a chronic obstructive pulmonary disease (COPD) model during noninvasive ventilation, compared with the pressure support ventilation (PSV) mode. Methods The Respironics V60 ventilator was connected to an ASL5000 lung simulator, which simulates lung mechanics in COPD (compliance, 50 mL/cmH2O; expiratory resistance, 20 cmH2O/L/s; respiratory rate, 15 breaths/min; inspiratory time, 1.6 s). PAV was applied with different assistance levels, including flow assist (FA, 40–90% respiratory resistance) and volume assist (VA, 50–90% elastance). PSV was assessed using the same model. Measurements were obtained at a leak flow rate of 25–28 L/min. Performance characteristics, simulator-ventilator synchrony, and WOB were assessed. Results Runaway was prone to occur, and severe premature cycling was observed with VA75+FA level > 65%. Compared with PSV, lower tidal volume (≤400 mL) was observed during PAV with VA75+FA40-50 and FA50+VA40-80; similar and improved cycling synchrony was observed for FA50+VA80 and FA50+VA90 (cycling delay: −117.60 ± 6.13 and −61.50 ± 8.03 vs. −101.20 ± 7.32 ms). The reduced triggering workload was observed for VA75+FA60-65 and FA50+VA80-90. Total and patient WOB was improved with all tested assist level combinations, except for FA50+VA90. Conclusions PAV reduces WOB but can induce asynchrony if improper settings are set, but the most optimal settings still need more clinical observations.

With the changes of modern warfare modes and the development of missiles and weapons, the battlefield survivability of military vehicles is facing severe challenges. Vehicles must have high protection performance and better mobility. However, both of them are contradictory each other. The advanced resin-based composites has excellent mechanical properties and strong designability, and is one of the main technical means to solve the above problems, but it also encounters a bottleneck. In view of these situations, this paper summarizes the development of advanced composites in recent years, and discusses in detail the protection mechanism of advanced composite materials, material selection and manufacturing processes, and the latest developments and future application trends of advanced composite materials for armor protection systems.

The damage mode and failure mechanism of the PBO composite are studied of the penetrating speed from 900 m/s to 1900 m/s, based on the dynamic response of the PBO fiber-reinforced composite target under high-speed penetration. Firstly, the mechanical properties of the projectile and the target material under high strain rate were characterized, and then the penetration of high-speed projectile into target is simulated. Finally, the penetration test is verified. The results show that the dynamic response mechanism of PBO composite target under high-speed penetration varies significantly with the penetrating speed.

This study aimed to investigate the use of polycarbonate (PC), acrylonitrile-butadiene-styrene (ABS), PC/ABS/maleinized acrylonitrile-butadiene-styrene copolymer (ABS-g-MAH) composite, PC/ABS/methyl methacrylate-butadiene-styrene (MBS) composite, and PC/ABS/organic montmorillonite composite for fused deposition modeling experiments and compare their mechanical properties. The tensile test results of specimens printed with different orientations revealed that PC/ABS compatibilized by 7% MBS exhibited the highest tensile elongation of the samples built in a horizontal orientation. Moreover, PC/ABS compatibilized by 6% ABS-g-MAH showed the greatest tensile strength between the three composite specimens printed with horizontal orientations. The notch impact test results revealed that PC/ABS/ABS-g-MAH and PC/ABS/MBS composite specimens printed with horizontal and vertical orientations were much stronger than the other systems.