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A case of spontaneous regression of malignant lymphoma of the maxillary gingiva following a biopsy is reported. An 84-year-old man was referred to the hospital with chief complaints of swelling of the anterior maxillary gingiva. A non-tender swelling with an ulcer was observed. There was no abnormal bone resorption in the anterior maxillary region and no swelling of the cervical lymph nodes. A biopsy was performed, and the patient was diagnosed with diffuse large B-cell lymphoma. The lesion regressed spontaneously 3 weeks after the initial biopsy. Two years have passed since the spontaneous regression and no recurrence has been observed. If malignant lymphoma regresses on biopsy, observation is considered to be sufficient.

Autism spectrum disorder (ASD) is a lifelong condition, and its underlying biological mechanisms remain elusive. The complexity of various factors, including inter-site and development-related differences, makes it challenging to develop generalizable neuroimaging-based biomarkers for ASD. This study used a large-scale, multi-site dataset of 730 Japanese adults to develop a generalizable neuromarker for ASD across independent sites (U.S., Belgium, and Japan) and different developmental stages (children and adolescents). Our adult ASD neuromarker achieved successful generalization for the US and Belgium adults (area under the curve [AUC] = 0.70) and Japanese adults (AUC = 0.81). The neuromarker demonstrated significant generalization for children (AUC = 0.66) and adolescents (AUC = 0.71; allP

For the development of electric propulsion aircrafts with light weight, low emission and high efficiency, MW-class fully superconducting synchronous machines operating at liquid nitrogen temperature were conceptually designed with REBa2Cu3O7- δ (REBCO) superconducting tapes in our previous studies. To verify the actualization of the structure and cooling method, a 1 kW-class prototype fully superconducting synchronous motor was designed and constructed in this study. The fixed armature was cooled with subcooled liquid nitrogen at 65 K. The rotor was cooled with helium gas. The pole number was two for the future high speed operation. The applicability of the complicated casing structure with three chambers into fully superconducting motor was also investigated from the viewpoint of thermal insulation. The operations as a motor up to 500 rpm and a generator demonstrated that the designed structure and cooling method were reasonable and effective for cooling the fixed armature and rotating field windings.

Groups are essential elements of society, and humans, by nature, commonly manifest intergroup bias (i.e., behave more positively toward an ingroup member than toward an outgroup member). Despite the growing evidence of various types of altered decision-making in individuals with autism spectrum disorder (ASD), their behavior under the situation involving group membership remains largely unexplored. By modifying a third-party punishment paradigm, we investigated intergroup bias in individuals with ASD and typical development (TD). In our experiment, participants who were considered as the third party observed a dictator game wherein proposers could decide how to distribute a provided amount of money while receivers could only accept unconditionally. Participants were confronted with two different group situations: the proposer was an ingroup member and the recipient was an outgroup member (IN/OUT condition) or the proposer was an outgroup member and the recipient was an ingroup member (OUT/IN condition). Participants with TD punished proposers more severely when violating social norms in the OUT/IN condition than in IN/OUT condition, indicating that their decisions were influenced by the intergroup context. This intergroup bias was attenuated in individuals with ASD. Our findings deepen the understanding of altered decision-making and socioeconomic behaviors in individuals with ASD.

We have developed a novel technique for the measurement of the size of avalanche fluctuations of gaseous detectors using a gating device (gating foil) prepared for the time projection chamber in the international linear collider experiment (ILD-TPC). In addition to the gating function, the gating foil is capable of controlling the average fraction of drift electrons detected after gas amplification. The signal charge width and shape (skewness) for electron-ion pairs created by a pulsed UV laser as a function of the transmission rate of the gating foil can be used to determine the relative variance of gas gain for single electrons. We present the measurement principle and the result obtained using a stack of gas electron multipliers (GEMs) operated in a gas mixture of Ar-CF$_4$(3%)-isobutane(2%) at atmospheric pressure. Also discussed is the influence of the avalanche fluctuations on the spatial resolution of the ILD-TPC., 39 pages including 11 figures

We have investigated the local structure of BiS2-based layered materials by Bi L3-edge extended X-ray absorption fine structure (EXAFS) measurements performed on single crystal samples with polarization of the X-ray beam parallel to the BiS2 plane. The results confirm highly instable nature of BiS2 layer, characterized by ferroelectric like distortions. The distortion amplitude, determined by the separation between the two in-plane (Bi-S1) bonds, is found to be highest in LaO0.77F0.23BiS2 with ΔR∼0.26 Å and lowest in NdO0.71F0.29BiS2 with ΔR∼0.13 Å. Among the systems with intrinsic doping, CeOBiS2 shows smaller distortion (ΔR∼0.15 Å) than PrOBiS2 (ΔR∼0.18 Å) while the highest distortion appears for EuFBiS2 revealing ΔR∼0.22 Å. It appears that the distortion amplitude is controlled by the nature of the RE(O,F) spacer layer in the RE(O,F)BiS2 structure. The X-ray absorption near edge structure (XANES) spectra, probing the local geometry, shows a spectral weight transfer that evolves systematically with the distortion amplitude in the BiS2-layer. The results provide a quantitative measurements of the local distortions in the instable BiS2-layer with direct implication on the physical properties of these materials.

Background The public health measures enacted in order to control the coronavirus disease (COVID-19) pandemic have caused considerable changes to daily life. For autistic children and adolescents, adapting to the “new normal,” including mask-wearing, may be difficult because of their restricted interest and repetitive behavior (RRB) characteristics. We aimed to examine the relationships between RRB characteristics and the impact of mask-wearing on their social communications during the pandemic. Methods We recruited participants with a clinical diagnosis of autism spectrum disorder based on DSM-5 diagnostic criteria from two outpatient clinics in Tokyo, Japan, between November 2020 and April 2021 using a convenience sampling methodology. As a result, the participants consisted of 102 children and adolescents (mean (SD) age = 11.6 (5.3)). We collected data on RRB characteristics frequency before and during the pandemic using the CoRonavIruS Health Impact Survey (CRISIS) – Adapted for Autism and Related Neurodevelopmental conditions (AFAR). We then conducted factor analyses to compute the RRB severity composite scores, which are divided into lower- (e.g., sensory seeking), and higher-order (e.g., restricted interest). We also investigated mask-wearing culture using a bespoke questionnaire, and using Spearman’s rank correlation analyses, we examined the relationships between before pandemic RRB characteristics, and the impact of mask-wearing on social communications during the pandemic. Results We found that children and adolescents who exhibited lower-order RRB before the pandemic had difficulties in going-out with mask-wearing (rho = -0.25, q = .031), more challenges with mask-wearing (rho = − 0.34, q = .0018), and difficulty in referring to others’ emotions while wearing masks (rho = − 0.36, q = .0016). We also found an association between higher-order RRB before the pandemic and an uncomfortable sensation (rho = − 0.42, q = .0002) and difficulties in referring to other’s emotions while wearing masks (rho = − 0.25, q = .031). Conclusions We revealed that various behaviors, such as sensory seeking, repetitive motor mannerisms and movements, and rituals and routines, undertaken before the pandemic could be important predictors of difficulties with mask-wearing and social communication for autistic children and adolescents during the pandemic. Caregivers and teachers wearing masks may need to provide extra support for social communication to autistic children and adolescents showing RRB characteristics frequently.

International audience; The role of brain dystrophin in muscular dystrophy: Implications for clinical care and translational research, Hoofddorp, the Netherlands, November 29 th-December 1 st 2019

Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few studies have examined these neurotransmissions in individuals with ASD in vivo. Here, we investigated DA D1 receptor (D1R) and noradrenaline transporter (NAT) binding in adults with ASD (n = 18) and neurotypical controls (n = 20) by utilizing two different PET radioligands, [11C]SCH23390 and (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences in DA D1R (striatum, anterior cingulate cortex, temporal cortex) or NAT (thalamus, pons) binding. However, in the ASD group, there were significant negative correlations between DA D1R binding (striatum, anterior cingulate cortex, temporal cortex) and the “attention to detail” subscale score of the Autism Spectrum Quotient. Further, there was a significant positive correlation between DA D1R binding (temporal cortex) and emotion perception ability assessed by the neurocognitive battery. Associations of NAT binding with empathic abilities and executive function were found in controls, but were absent in the ASD group. While a lack of significant group differences in binding might be partly due to the heterogeneity of ASD, our results indicate that central DA and NA function might play certain roles in the clinical characteristics of ASD.

Intergroup bias, which is the tendency to behave more positively toward an in-group member than toward an out-group member, is pervasive in real life. In particular, intergroup bias in trust decisions substantially influences multiple areas of life and thus better understanding of this tendency can provide significant insights into human social behavior. Although previous functional magnetic resonance imaging studies showed the involvement of the right temporoparietal junction (TPJ) in intergroup trust bias, a causal relationship between the two has rarely been explored. By combining repetitive transcranial magnetic stimulation and a newly developed trust game task, we investigated the causal role of the right TPJ in intergroup bias in trust decisions. In the trust game task, the counterpart's group membership (in-group or out-group) and reciprocity were manipulated. We applied either neuronavigated inhibitory continuous theta burst stimulation (cTBS) or sham stimulation over the right TPJ before performing the trust game task in healthy volunteers. After the sham stimulation, the participants' degrees of investments with in-group members were significantly higher than those with out-group members. However, after cTBS to the right TPJ, this difference was not observed. The current results extend previous findings by showing that the causal roles of the right TPJ can be observed in intergroup bias in trust decisions. Our findings add to our understanding of the mechanisms of human social behavior.

We calculate the $B \to D^{(*)} \ell \nu$ form factors in 2+1 flavor relativistic lattice QCD by employing the M\"obius domain-wall action for all quark flavors. Our simulations are carried out at lattice cut-offs $a^{-1} \sim 2.5$, 3.6 and 4.5 GeV with the bottom quark masses up to 0.7 $a^{-1}$ to control discretization effects. We extrapolate the form factors to the continuum limit and physical quark masses, and discuss systematic uncertainties of the form factors., Comment: 9 pages, 4 figures, talk presented at the 38th International Symposium on Lattice Field Theory (LATTICE2021), 26th-30th July, 2021, Zoom/Gather@MIT, USA

Since the exogenous compound tris(hydroxymethyl)aminomethane (Tris) showed a potent chemoattractant activity for Brugia pahangi infective third-stage larvae (L3), it was assumed that, in natural infection to a host, filarial L3 can be expected to recognize an endogenous Tris-related compound. In addition, a few amino acids have been identified as water-soluble attractants for second-stage juveniles of Meloidogyne incognita, a plant parasitic nematode. Therefore, the present study assesses the in vitro chemotactic responses of B. pahangi L3 to Tris-related compounds and amino acids using an agar-plate assay. Among Tris-related compounds, 2-amino-1,3-propanediol (APD) and 2-amino-2-methyl-1,3-propanediol (AMPD) exhibited a potent chemoattractant activity for filarial L3 at a level similar to Tris. Furthermore, arginine (Arg) was identified as a potent attractant for filarial L3 among amino acids. In addition, filarial L3 were attracted to Arg, APD and AMPD in mild alkaline conditions rather than acidic conditions. The chemoattractant activity of the three compounds for filarial L3 was observed in concentrations between 6.3 and 200 mm. This is the first report to demonstrate that Arg, APD and AMPD are potent chemoattractants for B. pahangi L3. Endogenous Arg and APD, in particular, may be involved in the regulation of the chemotactic behaviour of filarial L3 in the infection to a host. The present results will help to elucidate the mechanism of filarial skin-penetrating invasion of a host.

People are often influenced by past costs in their current decision-making, thus succumbing to a well-known bias recognized as the sunk cost effect. A recent study showed that the sunk cost effect is attenuated in individuals with autism spectrum disorder (ASD). However, the study only addressed one situation of utilization decision by focusing on the choice between similar attractive alternatives with different levels of sunk costs. Thus, it remains unclear how individuals with ASD behave under sunk costs in different types of decision situations, particularly progress decisions, in which the decision-maker allocates additional resources to an initially chosen alternative. The sunk cost effect in progress decisions was estimated using an economic task designed to assess the effect of the past investments on current decision-making. Twenty-four individuals with ASD and 21 age-, sex-, smoking status-, education-, and intelligence quotient-level-matched typical development (TD) subjects were evaluated. The TD participants were more willing to make the second incremental investment if a previous investment was made, indicating that their decisions were influenced by sunk costs. However, unlike the TD group, the rates of investments were not significantly increased after prior investments in the ASD group. The results agree with the previous evidence of a reduced sensitivity to context stimuli in individuals with ASD and help us obtain a broader picture of the impact of sunk costs on their decision-making. Our findings will contribute to a better understanding of ASD and may be useful in addressing practical implications of their socioeconomic behavior.

A new and comprehensive migration route of skipjack tuna, Katsuwonus pelamis, in the western Pacific Ocean was observed from the results of a large scale tagging project conducted from 2010 to 2016. Skipjack were implanted with archival tags in the peritoneal cavity and released from a subtropical area (STA), the Nansei Islands (NSI) and the Kuroshio Extension Area (KEA). Individuals released around the NSI displayed strong residency in that area. On the other hand, individuals released around the STA and KEA demonstrated seasonal northward movements. Three major potential routes were observed with strong skipjack residency along; (i) the Kuroshio in the NSI, and with seasonal northward movements along (ii) the Kyushu-Palau ridge and (iii) the Izu-Ogasawara Islands. During northward migration, the skipjack experienced several specific physical oceanographic structures such as the Kuroshio recirculation area (subtropical mode waters), the Kuroshio Current near the coast of Japan, the Kuroshio Extension and the Kuroshio–Oyashio transition area. However, during their journey the skipjack did not enter water with temperatures of ≤18 °C (defined as the lower thermal limit). Furthermore, the depth of the lower thermal limit is progressively shoaled at higher latitudes due to the distribution of colder water masses below 18 °C, which further limits the vertical distribution of skipjack. Our findings are the first fishery-independent observations on the degree of horizontal and vertical habitat of skipjack tuna in the western Pacific Ocean, which can be strongly driven by behavioural responses to the lower thermal limit.

This document updates the previous AMMI Canada Foundation Guidance (2013) on the use of antiviral therapy for influenza.Le présent document est une mise à jour des précédentes directives d’AMMI Canada (2013) sur l’utilisation des antiviraux contre la grippe.

We have investigated the electronic structure evolution with F doping in $\mathrm{Pr}{\mathrm{O}}_{1\ensuremath{-}x}{\mathrm{F}}_{x}\mathrm{Bi}{\mathrm{S}}_{2}$ ($x=0.0,0.3,0.5$) by means of angle-resolved photoemission spectroscopy. Undoped $\mathrm{Pr}\mathrm{O}\mathrm{Bi}{\mathrm{S}}_{2}$ exhibits Fermi surface (FS) pockets around the $X$ point which can be associated with electron doping due to the ${\mathrm{Pr}}^{3+}/{\mathrm{Pr}}^{4+}$ mixed valence. At $x=0.3$, the FS pockets are expanded, and their area is almost consistent with the F doping level. Interestingly, horizontal segments facing each other in the rectangular FS pockets lose their spectral weight. The partial suppression of the FS pockets suggests possible anisotropic charge fluctuations around $x=0.3$. At $x=0.5$, the FS area is much smaller than the expected value as commonly observed for $\mathrm{Ce}{\mathrm{O}}_{0.5}{\mathrm{F}}_{0.5}\mathrm{Bi}{\mathrm{S}}_{2}$ and $\mathrm{Nd}{\mathrm{O}}_{0.5}{\mathrm{F}}_{0.5}\mathrm{Bi}{\mathrm{S}}_{2}$. In addition, the highly depleted spectral weight at the FS pockets would be consistent with evident charge fluctuations driven by atomic disorder in the $\mathrm{Bi}{\mathrm{S}}_{2}$ network.

Cable corrosion significantly decreases the ultimate and fatigue strength of cable-stayed bridges. It might lead to lose the cables and may affect to the entire bridge significantly. In this paper, parametric studies with three different span lengths, different corrosion levels and loss of different cables were performed. Whereas the ultimate strength lowered by about 25% as the cross-sectional area decreased due to corrosion. The elongation also decreases due to corrosion. The ultimate strength was found to sharply drop when the elongation became 1.0%. The fatigue strength of stays was studied taking a 500kN heavy lorry as the representative load. The fatigue strength sharply lowers as corrosion progresses and the severely corrode anchor cable becomes less than 4% of the healthy one. The anchor cables showed the most significant effect to the entire bridges.

Since the exogenous compound tris(hydroxymethyl)aminomethane (Tris) showed a potent chemoattractant activity for Brugia pahangi infective third-stage larvae (L3), it was assumed that, in natural infection to a host, filarial L3 can be expected to recognize an endogenous Tris-related compound. In addition, a few amino acids have been identified as water-soluble attractants for second-stage juveniles of Meloidogyne incognita, a plant parasitic nematode. Therefore, the present study assesses the in vitro chemotactic responses of B. pahangi L3 to Tris-related compounds and amino acids using an agar-plate assay. Among Tris-related compounds, 2-amino-1,3-propanediol (APD) and 2-amino-2-methyl-1,3-propanediol (AMPD) exhibited a potent chemoattractant activity for filarial L3 at a level similar to Tris. Furthermore, arginine (Arg) was identified as a potent attractant for filarial L3 among amino acids. In addition, filarial L3 were attracted to Arg, APD and AMPD in mild alkaline conditions rather than acidic conditions. The chemoattractant activity of the three compounds for filarial L3 was observed in concentrations between 6.3 and 200 mm. This is the first report to demonstrate that Arg, APD and AMPD are potent chemoattractants for B. pahangi L3. Endogenous Arg and APD, in particular, may be involved in the regulation of the chemotactic behaviour of filarial L3 in the infection to a host. The present results will help to elucidate the mechanism of filarial skin-penetrating invasion of a host.

Nature of the field-induced charge-ordered phase (phase II) of $\mathrm{Sm}{\mathrm{Ru}}_{4}{\mathrm{P}}_{12}$ has been investigated by resonant x-ray diffraction (RXD) and polarized neutron diffraction (PND), focusing on the relationship between the atomic displacements and the antiferromagnetic (AFM) moments of Sm. From the analysis of the interference between the nonresonant Thomson scattering and the resonant magnetic scattering, combined with the spectral function obtained from x-ray magnetic circular dichroism, it is shown that the AFM moment of Sm prefers to be parallel to the field (${\mathbit{m}}_{\text{AF}}\ensuremath{\parallel}\mathbit{H}$), giving rise to large and small moment sites around which the ${\mathrm{P}}_{12}$ and Ru cage contract and expand, respectively. This is associated with the formation of the staggered ordering of the ${\mathrm{\ensuremath{\Gamma}}}_{7}$-like and ${\mathrm{\ensuremath{\Gamma}}}_{8}$-like crystal-field states, providing a strong piece of evidence for the charge order. PND was also performed to obtain complementary and unambiguous conclusion. In addition, isotropic and continuous nature of phase II is demonstrated by the field-direction invariance of the interference spectrum in RXD. Crucial role of the $p\ensuremath{-}f$ hybridization is shown by resonant soft x-ray diffraction at the P $K$ edge ($1s\ensuremath{\leftrightarrow}3p$), where we detected a resonance due to the spin polarized $3p$ orbitals reflecting the AFM order of Sm.

This paper presents design challenges and solutions for the fifth generation (5G) phased-array transceiver ICs in millimeter-wave (MMW) frequency bands. A 28nm bulk CMOS device technology is selected to integrate multiple RF phased-array elements in a single-chip to achieve a high-level of TX EIRP and RX sensitivity. Several design approaches of gain, P OUT , stability, reliability and linearity enhancement techniques are applied to enable CMOS as a key device solution for 5G applications in MMW frequency bands. A 39GHz band 16-channel CMOS RF phased-array transceiver IC is designed and can support 4T/4R MIMO base-station applications including ×64 RF phased-array ICs (total 1,024 phased-array elements). T/RX paths have gain dynamic ranges of >30/40dB for flexibility and scalability. The TX path shows P OUT /Ch. of >6.0dBm at EVM of -34dB (800MHz) and P DC /Ch. of 105mW. The RX path performs NF of 4.2dB, EVM of -38dB (100MHz) and P DC /Ch. of 39mW. These state-of-the-art results lead to TX EIRP of >55dBm and RX sensitivity of

Introduction Female lower urinary tract symptoms (LUTS) affect quality of life and sexual activity. Objectives This study aimed to evaluate the influences of LUTS on female dyspareunia (pain during vaginal penetration), as little is known on this topic. Methods The study population comprised 369 women who participated in 2-day health examinations at a single institution in Japan, from April 2010 to March 2011. All participants were asked to complete a standardized self-reported questionnaire. Using the International Prostate Symptom Score (IPSS), IPSS-QOL score, and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), we evaluated urinary symptoms, including urinary incontinence, urgency, daytime frequency, straining, and nocturia. To assess dyspareunia, we asked the question "Over the past 4 weeks, how often did you experience discomfort or pain during vaginal penetration?", with answer choices of "Did not attempt intercourse", "Almost always or always", "Most times", "Sometimes", “A few times”, and "Almost never or never", from part of a questionnaire from the Japanese translation of the Female Sexual Function Index (Question 17 of FSFI-J) [Rosen. J Sex Marital Ther, 2000]. We analyzed relationships between dyspareunia and LUTS. The Mann-Whitney U test and logistic regression models were used for statistical analyses. Values of P Results A total of 315 individuals completed the questionnaire (response rate, 84%). The mean age of respondents was 47.2 years (range, 31-69 years). Our analysis included 125 women (40%), and excluded 190 women (60%) who reported that they had not attempted intercourse over the past 4 weeks. Among sexually active women, 44% had experienced dyspareunia. Straining to void and IPSS-QOL score were significantly higher in women reporting dyspareunia. In multivariate analysis, significant correlations were found between dyspareunia and both straining to void and IPSS-QOL score (Odds ratio, 16.9 (1.38-205)). Conclusion Straining to void and IPSS-QOL score correlated significantly with dyspareunia among Japanese women in this study. The underlying mechanism remains unclear, and little data have been accumulated on the association between straining to void and dyspareunia, although a previous study reported LUTS as a predictor of sexual pain for women in the United States (odds ratio = 7.61) [Laumann. JAMA, 1999]. Our study confirmed straining to void and IPSS-QOL score as factors independently associated with dyspareunia. These results suggest that straining to void can offer a predictor of female dyspareunia. Disclosure Work supported by industry: no.

We provide an update to the Association of Medical Microbiology and Infectious Disease Canada foundation guidance for the upcoming 2020-2021 influenza season in Canada. Important issues for this year include the implications of co-circulation of SARS-CoV-2, the role of diagnostic testing, and a restatement of dosing and administration recommendations for neuraminidase inhibitors in various age groups and underlying health conditions. Although peramivir and baloxivir are now licensed in Canada, neither is currently marketed, so this guidance focuses on further optimizing the use of oseltamivir and zanamivir.Nous actualisons l’information sur les directives de la Fondation de l’Association pour la microbiologie médicale et l'infectiologie Canada en vue de la saison grippale 2020–2021 au Canada. Cette année, les enjeux importants touchent les conséquences de la co-circulation de la maladie à coronavirus 2019, le rôle des tests diagnostiques et la réaffirmation des recommandations relatives aux maladies sous-jacentes ainsi qu’à la posologie et à l’administration des inhibiteurs de la neuraminidase dans divers groupes d’âge. Même si le péramivir et le baloxivir sont désormais homologués au Canada, ces médicaments n’y sont pas encore commercialisés, et c’est pourquoi les présentes directives visent à optimiser l’utilisation de l’oseltamivir et du zanamivir.

Background It is uncertain whether curative surgical treatment or a less radical surgery with adjuvant treatment should be provided to preserve function in patients with vulvar squamous cell carcinoma (SCC) that is adjacent to the urethra, anus, and vagina. The aim of this study was to investigate the surgical margin in patients with vulvar SCC with regard to local recurrence and overall survival. Methods Thirty-four patients were identified as having a diagnosis of vulvar SCC without distant metastasis. They had been treated surgically with curative intent at the Cancer Institute Hospital between May 1992 and January 2019. Clinical data were analyzed retrospectively. Results Rates of 5-year local recurrence-free survival among patients with positive, Conclusion To improve the prognosis, thorough resection with an adequate surgical margin is needed.

Most healthy people fully recover from influenza illness without medical intervention or antiviral treatment However, given the potential for suboptimal VE this season, antiviral therapy may be of particular importance in the management of individuals with suspected influenza illness despite documentation of having received the 2019–2020 influenza vaccine