5,941 results on '"Xin, Ying"'
Search Results
2. Effect of microplatelet orientation in 3D printed microplatelet-reinforced composites with bioinspired microstructures
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Peng, Weixiang, Chan, Xin Ying, Lee, Seo Hyeong, and Le Ferrand, Hortense
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- 2024
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3. Recent Insights into the Roles of PEST‐Containing Nuclear Protein
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Guo, Shiyun, Ding, Ruidong, Zhao, Qian, Wang, Xu, Lv, Shuangyu, and Ji, Xin-Ying
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- 2024
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4. MusicEmo: transformer-based intelligent approach towards music emotion generation and recognition
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Xin, Ying
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- 2024
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5. Prevalence of hypertension and its associations with body composition across Chinese and American children and adolescents
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Gao, Li-Wang, Huang, Yi-Wen, Cheng, Hong, Wang, Xi, Dong, Hong-Bo, Xiao, Pei, Yan, Yin-Kun, Shan, Xin-Ying, Zhao, Xiao-Yuan, and Mi, Jie
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- 2024
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6. On the 'Loose' Constraint from IceCube Neutrino Non-Detection of GRB 230307A
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Song, Xin-Ying
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The recent extremely bright gamma-ray burst (GRB), GRB 230307A from a binary neutron star merger may offer a good probe for the production of GRB-neutrinos. Within the constraint from IceCube neutrino non-detection, the limits for key physical parameters of this burst are extracted in different scenarios including the fireball, Poynting-flux-dominated (PFD) and hybrid jet. Different from the former nearby `monsters' and due to its smaller isotropic equivalent radiated energy ($E_{\gamma,\rm iso}\sim4\times10^{52}$ erg), the constraint seems loose if non-thermal neutrinos produced from photomeson interactions are the only consideration. However, a quasi-thermal neutrino emission from hadronuclear processes is constrained in this neutron-rich post-merger environment, and the upper limit of the allowed nucleon loading factor is about a few. Based on this, a discussion is presented on the possible prompt emission mechanism and jet composition for GRB 230307A in the context of multi-messenger astrophysics. It is worth noting that till now no GRB-neutrinos have been ever detected, even for the two brightest nearby GRBs ever observed (GRB 221009A and GRB 230307A) which have different dissipation mechanisms., Comment: Published in ApJ 958,133;accepted for publication in ApJ on Oct. 11; 13 pages, 3 figures. submitted on 2023.08.11. Minor revision according to the reviwer's suggestions on Oct. 02
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- 2023
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7. GRB 221009A with an unconventional precursor: a typical two-stage collapsar scenario?
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Song, Xin-Ying and Zhang, Shuang-Nan
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
As the brightest Gamma-Ray burst (GRB) ever detected, GRB 221009A may offer a chance that reveals some interesting features which are hidden in those bursts that are not so bright. There seems a very weak emission with a flux of $10^{-8}\sim10^{-7}$ erg cm$^{-2}$ s$^{-1}$ between the first pulse ($T_0\sim T_0+50$~s, $T_0$ is the trigger time) and the main burst (appears from $T_0+180$ s). Thus the gap time between them is not really quiescent, and the first pulse could be taken as an unconventional precursor, which may provide a peculiar case study for the GRB-precursor phenomena. A two-stage collapsar scenario is proposed as the most likely origin for this burst. In this model, the jet for the precursor is produced during the initial core-collapse phase, and should be weak enough not to disrupt the star when it breaks out of the envelope, so that the fallback accretion process and the forming of the disk could continue. We present an approach in which the duration and flux both provide constraints on the luminosity ($L_{\rm j}$) and the Lorentz factor at the breakout time ($\Gamma_{\rm b}$) of this weak jet. The estimated $L_{\rm j}\lesssim 10^{49}$ erg s$^{-1}$ and $\Gamma_{\rm b}$ has an order of ten, which are well consistent with the theoretical prediction. Besides, the weak emission in the gap time could be interpreted as a MHD outflow due to a magnetically driven wind during the period from the proto-neutron star phase to forming the accretion disk in this scenario., Comment: 12 pages, 5 figures, published in ApJ
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- 2023
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8. Spectral and Jet Properties of the Quasi-thermal Dominated GRB 210121A, GRB 210610B and GRB 221022B
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Song, Xin-Ying, Wang, Ling-Jun, and Zhang, Shu
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Phenomenology - Abstract
Some quasi-thermal (QT) dominated gamma-ray bursts (GRBs) could be well described by a multi-color blackbody (BB) function or a combined model of BB plus non-thermal (NT) component. In this analysis, two QT radiation-dominated bursts with known emission properties (GRB 210610B likely from a hybrid jet, and GRB 210121A with a spectrum consistent with a non-dissipative photospheric emission from a pure hot fireball) are used to make a comparison between these two modelings. To diagnose the magnetization properties of the central engine, the `top-down' approach proposed by Gao \& Zhang is adopted. It is found that diagnoses based on these two modelings could provide similar conclusions qualitatively; however, the modeling with mBB (or mBB+NT) may give more reasonable physical explanations. This implies that impacts from the GRB jet structure and the geometrical broadening on the observed spectrum should be considered. However, conservatively, these methods may be not sensitive enough to distinguish between the pure hot fireball and a mildly magnetized hybrid jet. Some other information is necessary to provide more evidence for the determination of jet properties for similar GRBs. Based on these considerations, we suggest that the photospheric emission of GRB 221022B is from a hot jet; a dissipation is caused by a internal shock (IS) mechanism due to the increasing Lorentz Factor with time, which makes its prompt emission behaves a typical evolution from thermal to NT., Comment: Published in ApJ on Jan 19th 2024. Accepted for publication in The ApJ on 19 Nov. 16 pages, 6 figures, 3 tables, submitted to ApJ on 06-May-2023
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- 2023
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9. High-quality reference genome of cowpea beetle Callosobruchus maculatus
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Hao-Ran Lu, Chu-Yang Mao, Li-Jie Zhang, Jin-Wu He, Xie-Shuang Wang, Xin-Ying Zhang, Wei-Li Fan, Zheng-Zhong Huang, Le Zong, Chu-Han Cui, Feng-Ming Wu, Xue-Li Wang, Zhen Zou, Xue-Yan Li, and Si-Qin Ge
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Science - Abstract
Abstract Callosobruchus maculatus is one of the most competitive stored grain pests, which causes a great loss to agricultural economy. However, due to an inadequacy of high-quality reference genome, the molecular mechanisms for olfactory and hypoxic adaptations to stored environments are unknown and require to be revealed urgently, which will contribute to the detection and prevention of the invasive pests C. maculatus. Here, we presented a high-quality chromosome-level genome of C. maculatus based on Illumina, Nanopore and Hi-C sequencing data. The total size was 1.2 Gb, and 65.17% (797.47 Mb) of it was identified to be repeat sequences. Among assembled chromosomes, chromosome 10 was considered the X chromosome according to the evidence of reads coverage and homologous genes among species. The current version of high-quality genome provides preferable data resources for the adaptive evolution research of C. maculatus.
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- 2024
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10. Nuclear proteins and diabetic retinopathy: a review
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Bin Li, Wahab Hussain, Zhi-Liang Jiang, Jia-Yi Wang, Sarfraz Hussain, Talat Bilal Yasoob, Yuan-Kun Zhai, Xin-Ying Ji, and Ya-Long Dang
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Diabetic retinopathy ,Nuclear protein ,Non-proliferative diabetic retinopathy ,Medical technology ,R855-855.5 - Abstract
Abstract Diabetic retinopathy (DR) is an eye disease that causes blindness and vision loss in diabetic. Risk factors for DR include high blood glucose levels and some environmental factors. The pathogenesis is based on inflammation caused by interferon and other nuclear proteins. This review article provides an overview of DR and discusses the role of nuclear proteins in the pathogenesis of the disease. Some core proteins such as MAPK, transcription co-factors, transcription co-activators, and others are part of this review. In addition, some current advanced treatment resulting from the role of nuclear proteins will be analyzes, including epigenetic modifications, the use of methylation, acetylation, and histone modifications. Stem cell technology and the use of nanobiotechnology are proposed as promising approaches for a more effective treatment of DR.
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- 2024
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11. Fluoride impairs vascular smooth muscle A7R5 cell lines via disrupting amino acids metabolism
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Yan-Shu Li, Ru-Ru Yang, Xin-Ying Li, Wei-Wei Liu, Yi-Ming Zhao, Ming-Man Zu, Yi-Hong Gao, Min-Qi Huo, Yu-Ting Jiang, and Bing-Yun Li
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Cardiovascular ,Metabolomics ,Amino acids metabolism ,Medicine - Abstract
Abstract Given the insidious and high-fatality nature of cardiovascular diseases (CVDs), the emergence of fluoride as a newly identified risk factor demands serious consideration alongside traditional risk factors. While vascular smooth muscle cells (VSMCs) play a pivotal role in the progression of CVDs, the toxicological impact of fluoride on VSMCs remains largely uncharted. In this study, we constructed fluorosis model in SD rats and A7R5 aortic smooth muscle cell lines to confirm fluoride impaired VSMCs. Fluoride aggravated the pathological damage of rat aorta in vivo. Then A7R5 were exposed to fluoride with concentration ranging from 0 to 1200 μmol/L over a 24-h period, revealing a dose-dependent inhibition of cell proliferation and migration. The further metabolomic analysis showed alterations in metabolite profiles induced by fluoride exposure, notably decreasing organic acids and lipid molecules level. Additionally, gene network analysis underscored the frequency of fluoride's interference with amino acids metabolism, potentially impacting the tricarboxylic acid (TCA) cycle. Our results also highlighted the ATP-binding cassette (ABC) transporters pathway as a central element in VSMC impairment. Moreover, we observed a dose-dependent increase in osteopontin (OPN) and α-smooth muscle actin (α-SMA) mRNA level and a dose-dependent decrease in ABC subfamily C member 1 (ABCC1) and bestrophin 1 (BEST1) mRNA level. These findings advance our understanding of fluoride as a CVD risk factor and its influence on VSMCs and metabolic pathways, warranting further investigation into this emerging risk factor.
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- 2024
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12. Insight-HXMT and GECAM-C observations of the brightest-of-all-time GRB 221009A
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An, Zheng-Hua, Antier, S., Bi, Xing-Zi, Bu, Qing-Cui, Cai, Ce, Cao, Xue-Lei, Camisasca, Anna-Elisa, Chang, Zhi, Chen, Gang, Chen, Li, Chen, Tian-Xiang, Chen, Wen, Chen, Yi-Bao, Chen, Yong, Chen, Yu-Peng, Coughlin, Michael W., Cui, Wei-Wei, Dai, Zi-Gao, Hussenot-Desenonges, T., Du, Yan-Qi, Du, Yuan-Yuan, Du, Yun-Fei, Fan, Cheng-Cheng, Frontera, Filippo, Gao, He, Gao, Min, Ge, Ming-Yu, Gong, Ke, Gu, Yu-Dong, Guan, Ju, Guo, Dong-Ya, Guo, Zhi-Wei, Guidorzi, Cristiano, Han, Da-Wei, He, Jian-Jian, He, Jun-Wang, Hou, Dong-Jie, Huang, Yue, Huo, Jia, Ji, Zhen, Jia, Shu-Mei, Jiang, Wei-Chun, Kann, David Alexander, Klotz, A., Kong, Ling-Da, Lan, Lin, Li, An, Li, Bing, Li, Chao-Yang, Li, Cheng-Kui, Li, Gang, Li, Mao-Shun, Li, Ti-Pei, Li, Wei, Li, Xiao-Bo, Li, Xin-Qiao, Li, Xu-Fang, Li, Yan-Guo, Li, Zheng-Wei, Liang, Jing, Liang, Xiao-Hua, Liao, Jin-Yuan, Lin, Lin, Liu, Cong-Zhan, Liu, He-Xin, Liu, Hong-Wei, Liu, Jia-Cong, Liu, Xiao-Jing, Liu, Ya-Qing, Liu, Yu-Rong, Lu, Fang-Jun, Lu, Hong, Lu, Xue-Feng, Luo, Qi, Luo, Tao, Ma, Bin-Yuan, Ma, Fu-Li, Ma, Rui-Can, Ma, Xiang, Maccary, Romain, Mao, Ji-Rong, Meng, Bin, Nie, Jian-Yin, Orlandini, Mauro, Ou, Ge, Peng, Jing-Qiang, Peng, Wen-Xi, Qiao, Rui, Qu, Jin-Lu, Ren, Xiao-Qin, Shi, Jing-Yan, Shi, Qi, Song, Li-Ming, Song, Xin-Ying, Su, Ju, Sun, Gong-Xing, Sun, Liang, Sun, Xi-Lei, Tan, Wen-Jun, Tan, Ying, Tao, Lian, Tuo, You-Li, Turpin, Damien, Wang, Jin-Zhou, Wang, Chen, Wang, Chen-Wei, Wang, Hong-Jun, Wang, Hui, Wang, Jin, Wang, Ling-Jun, Wang, Peng-Ju, Wang, Ping, Wang, Wen-Shuai, Wang, Xiang-Yu, Wang, Xi-Lu, Wang, Yu-Sa, Wang, Yue, Wen, Xiang-Yang, Wu, Bo-Bing, Wu, Bai-Yang, Wu, Hong, Xiao, Sheng-Hui, Xiao, Shuo, Xiao, Yun-Xiang, Xie, Sheng-Lun, Xiong, Shao-Lin, Xiong, Sen-Lin, Xu, Dong, Xu, He, Xu, Yan-Jun, Xu, Yan-Bing, Xu, Ying-Chen, Xu, Yu-Peng, Xue, Wang-Chen, Yang, Sheng, Yang, Yan-Ji, Yang, Zi-Xu, Ye, Wen-Tao, Yi, Qi-Bin, Yi, Shu-Xu, Yin, Qian-Qing, You, Yuan, Yu, Yun-Wei, Yu, Wei, Yu, Wen-Hui, Zeng, Ming, Zhang, Bing, Zhang, Bin-Bin, Zhang, Da-Li, Zhang, Fan, Zhang, Hong-Mei, Zhang, Juan, Zhang, Liang, Zhang, Peng, Zhang, Shu, Zhang, Shuang-Nan, Zhang, Wan-Chang, Zhang, Xiao-Feng, Zhang, Xiao-Lu, Zhang, Yan-Qiu, Zhang, Yan-Ting, Zhang, Yi-Fei, Zhang, Yuan-Hang, Zhang, Zhen, Zhao, Guo-Ying, Zhao, Hai-Sheng, Zhao, Hong-Yu, Zhao, Qing-Xia, Zhao, Shu-Jie, Zhao, Xiao-Yun, Zhao, Xiao-Fan, Zhao, Yi, Zheng, Chao, Zheng, Shi-Jie, Zhou, Deng-Ke, Zhou, Xing, and Zhu, Xiao-Cheng
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRB 221009A is the brightest gamma-ray burst ever detected since the discovery of this kind of energetic explosions. However, an accurate measurement of the prompt emission properties of this burst is very challenging due to its exceptional brightness. With joint observations of \textit{Insight}-HXMT and GECAM-C, we made an unprecedentedly accurate measurement of the emission during the first $\sim$1800 s of GRB 221009A, including its precursor, main emission (ME, which dominates the burst in flux), flaring emission and early afterglow, in the hard X-ray to soft gamma-ray band from $\sim$ 10 keV to $\sim$ 6 MeV. Based on the GECAM-C unsaturated data of the ME, we measure a record-breaking isotropic equivalent energy ($E_{\rm iso}$) of $\bf \sim 1.5 \times 10^{55}$ erg, which is about eight times the total rest-mass energy of the Sun. The early afterglow data require a significant jet break between 650 s and 1100 s, most likely at $\sim950$ s from the afterglow starting time $T_{AG}$, which corresponds to a jet opening angle of $\sim {0.7^\circ} \ (\eta_\gamma n)^{1/8}$, where $n$ is the ambient medium density in units of $\rm cm^{-3}$ and $\eta_\gamma$ is the ratio between $\gamma$-ray energy and afterglow kinetic energy. The beaming-corrected total $\gamma$-ray energy $E_{\gamma}$ is $\sim 1.15 \times10^{51} \ (\eta_\gamma n)^{1/4}$ erg, which is typical for long GRBs. These results suggest that this GRB may have a special central engine, which could launch and collimate a very narrowly beamed jet with an ordinary energy budget, leading to exceptionally luminous gamma-ray radiation per unit solid angle. Alternatively, more GRBs might have such a narrow and bright beam, which are missed by an unfavorable viewing angle or have been detected without distance measurement., Comment: Submitted to National Science Review. This paper is under press embargo, contact the corresponding author for details
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- 2023
13. The benefits and limitations of contextual theology: Hearing the voices of creation and the poor
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Lim, Xin Ying Cheryl
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- 2024
14. Context Autoencoder for Self-supervised Representation Learning
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Chen, Xiaokang, Ding, Mingyu, Wang, Xiaodi, Xin, Ying, Mo, Shentong, Wang, Yunhao, Han, Shumin, Luo, Ping, Zeng, Gang, and Wang, Jingdong
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- 2024
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15. Intrinsic Wave Velocity Propagation: A Novel Parameter for Assessing the Effect of Anthracycline Chemotherapy Agents on Cardiac Diastolic Function in Breast Cancer Patients
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Huang, Xiao, Fan, Xin-ying, Cheng, Qiao, Zhang, Jun, Sun, Jie, Tang, Qiao-ying, Deng, You-bin, and Bi, Xiao-jun
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- 2023
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16. Burden of Medication Overuse in Migraine: A Cross-sectional, Population-Based Study in Five European Countries Using the 2020 National Health and Wellness Survey (NHWS)
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Dissing, Agnete Skovlund, Lee, Xin Ying, Østerberg, Ole, and Hammer-Helmich, Lene
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- 2023
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17. Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
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Xin, Ying, Li, Keming, Huang, Miao, Liang, Chenyu, Siemann, Dietmar, Wu, Lizi, Tan, Youhua, and Tang, Xin
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- 2023
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18. GECAM Localization of High Energy Transients and the Systematic Error
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Zhao, Yi, Xue, Wang-Chen, Xiong, Shao-Lin, Wang, Yuan-Hao, Liu, Jia-Cong, Liuo, Qi, Zhang, Yan-Qiu, Sun, Jian-Chao, Zhao, Xiao-Yun, Cai, Ce, Xiao, Shuo, Huang, Yue, Li, Xiao-Bo, Zhang, Zhen, Liao, Jin-Yuan, Yang, Sheng, Qiao, Rui, Guo, Dong-Ya, Zheng, Chao, Yi, Qi-Bin, Xie, Sheng-Lun, Guo, Zhi-Wei, Li, Chao-Yang, Wang, Chen-Wei, Tan, Wen-Jun, Wang, Yue, Peng, Wen-Xi, Zheng, Shi-Jie, He, Jian-Jian, Wang, Ping, Wang, Jin, Ma, Xiang, Song, Xin-Ying, Zhang, Hong-Mei, Li, Bing, Zhang, Peng, Wu, Hong, Du, Yan-Qi, Liang, Jing, Zhao, Guo-Ying, Li, Xin-Qiao, Wen, Xiang-Yang, An, Zheng-Hua, Sun, Xi-Lei, Xu, Yan-Bing, Zhang, Fan, Zhang, Da-Li, Gong, Ke, Liu, Ya-Qing, Liang, Xiao-Hua, Liu, Xiao-Jing, Gao, Min, Wang, Jin-Zhou, Song, Li-Ming, Chen, Gang, Zhang, Ke-Ke, Han, Xing-Bo, Wu, Hai-Yan, Hu, Tai, Geng, Hao, Lu, Fang-Jun, Zhang, Shu, Zhang, Shuang-Nan, Lu, Gao-Peng, Zeng, Ming, and Yu, Heng
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a pair of microsatellites (i.e. GECAM-A and GECAM-B) dedicated to monitoring gamma-ray transients including gravitational waves high-energy electromagnetic counterparts, Gamma-ray Bursts, Soft Gamma-ray Repeaters, Solar Flares and Terrestrial Gamma-ray Flashes. Since launch in December 2020, GECAM-B has detected hundreds of astronomical and terrestrial events. For these bursts, localization is the key for burst identification and classification as well as follow-up observations in multi-wavelength. Here, we propose a Bayesian localization method with Poisson data with Gaussian background profile likelihood to localize GECAM bursts based on the burst counts distribution in detectors with different orientations. We demonstrate that this method can work well for all kinds of bursts, especially for extremely short ones. In addition, we propose a new method to estimate the systematic error of localization based on a confidence level test, which can overcome some problems of the existing method in literature. We validate this method by Monte Carlo simulations, and then apply it to a burst sample with accurate location and find that the mean value of the systematic error of GECAM-B localization is $\sim 2.5^{\circ}$. By considering this systematic error, we can obtain a reliable localization probability map for GECAM bursts. Our methods can be applied to other gamma-ray monitors., Comment: The paper has been accepted by Astrophysical Journal Supplement Series
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- 2022
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19. An economic evaluation of eptinezumab for the preventive treatment of migraine in the UK, with consideration for natural history and work productivity
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Edward Griffin, Gawain Shirley, Xin Ying Lee, Susanne F. Awad, Alok Tyagi, and Peter J. Goadsby
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Eptinezumab ,Anti-CGRP mAbs ,Migraine ,Cost-effectiveness ,Healthcare costs ,Natural history ,Medicine - Abstract
Abstract Background Migraine is a highly prevalent neurological disease with a substantial societal burden due to lost productivity. From a societal perspective, we assessed the cost-effectiveness of eptinezumab for the preventive treatment of migraine. Methods An individual patient simulation of discrete competing events was developed to evaluate eptinezumab cost-effectiveness compared to best supportive care for adults in the United Kingdom with ≥ 4 migraine days per month and prior failure of ≥ 3 preventive migraine treatments. Individuals with sampled baseline characteristics were created to represent this population, which comprised dedicated episodic and chronic migraine subpopulations. Clinical efficacy, utility, and work productivity inputs were based on results from the DELIVER randomised controlled trial (NCT04418765). Timing of natural history events and treatment holidays—informed by the literature—were simulated to unmask any natural improvement of the disease unrelated to treatment. The primary outcomes were monthly migraine days, migraine-associated costs, quality-adjusted life years (QALYs), incremental cost-effectiveness ratio, and net monetary benefit, each evaluated over a 5-year time horizon from 2020. Secondary analyses explored a lifetime horizon and an alternative treatment stopping rule. Results Treatment with eptinezumab resulted in an average of 0.231 QALYs gained at a saving of £4,894 over 5 years, making eptinezumab dominant over best supportive care (i.e., better health outcomes and less costly). This result was confirmed by the probabilistic analysis and all alternative assumption scenarios under the same societal perspective. Univariate testing of inputs showed net monetary benefit was most sensitive to the number of days of productivity loss, and monthly salary. Conclusions This economic evaluation shows that from a societal perspective, eptinezumab is a cost-effective treatment in patients with ≥ 4 migraine days per month and for whom ≥ 3 other preventive migraine treatments have failed. Trial registration N/A. Graphical Abstract
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- 2024
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20. Structural equation modeling for identifying the drivers of health-related quality of life improvement experienced by patients with migraine receiving eptinezumab
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Linus Jönsson, Susanne F. Awad, Stephane A. Regnier, Brian Talon, Steven Kymes, Xin Ying Lee, and Peter J. Goadsby
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Eptinezumab ,Migraine ,Treatment efficacy ,Structural equation modeling ,Medicine - Abstract
Abstract Background As new migraine therapies emerge, it is crucial for measures to capture the complexities of health-related quality of life (HRQoL) improvement beyond improvements in monthly migraine day (MMD) reduction. Investigations into the correlations between MMD reduction, symptom management, and HRQoL are lacking, particularly those that focus on improvements in canonical symptoms and improvement in patient-identified most-bothersome symptoms (PI-MBS), in patients treated with eptinezumab. This exploratory analysis identified efficacy measures mediating the effect of eptinezumab on HRQoL improvements in patients with migraine. Methods Data from the DELIVER study of patients with 2–4 prior preventive migraine treatment failures (NCT04418765) were inputted to two structural equation models describing sources of HRQoL improvement via Migraine-Specific Quality-of-Life Questionnaire (MSQ) scores. A single latent variable was defined to represent HRQoL and describe the sources of HRQoL in DELIVER. One model included all migraine symptoms while the second model included the PI-MBS as the only migraine symptom. Mediating variables capturing different aspects of efficacy included MMDs, other canonical symptoms, and PI-MBS. Results In the first model, reductions in MMDs and other canonical symptoms accounted for 35% (standardized effect size [SES] − 0.11) and 25% (SES − 0.08) of HRQoL improvement, respectively, with 41% (SES − 0.13) of improvement comprising “direct treatment effect,” i.e., unexplained by mediators. In the second model, substantial HRQoL improvement with eptinezumab (86%; SES − 0.26) is due to MMD reduction (17%; SES − 0.05) and change in PI-MBS (69%; SES − 0.21). Conclusions Improvements in HRQoL experienced by patients treated with eptinezumab can be substantially explained by its effect on migraine frequency and PI-MBS. Therefore, in addition to MMD reduction, healthcare providers should discuss PI-MBS improvements, since this may impact HRQoL. Health technology policymakers should consider implications of these findings in economic evaluation, as they point to alternative measurement of quality-adjusted life years to capture fully treatment benefits in cost-utility analyses. Trial registration ClinicalTrials.gov (Identifier: NCT04418765 ; EudraCT (Identifier: 2019–004497-25; URL: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2019-004497-25 ). Graphical Abstract
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- 2024
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21. Analysis of related factors for neuropsychiatric comorbidities in children with epilepsy
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Xin-Ying Zhang, Meng Sun, Jiang-Ya Wang, Fang-Fang Du, Xue-Fei Liu, Ling-Jun Wang, Zhen-De Hou, and Ya-Ying Cheng
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Children ,Cognitive impairment ,Epilepsy ,Psycho behavioral disorder ,Risk factors ,Medicine - Abstract
Abstract Objective To analyze the risk factors affecting psychiatric behavior and study the psychobehavioral conditions of children with epilepsy. Method We randomly selected and enrolled 294 children with epilepsy who visited and were hospitalized in the pediatric clinic of Hebei General Hospital between January 2017 and January 2022, as the study participants. We comprehensively assessed their cognitive functions using the Gesell development schedule or Wechsler Intelligence Scales. The participants were divided into the study group (n = 123) with cognitive impairment and the control group (n = 171) with normal cognitive functions, for analysis. Results There were statistically significant differences between the two groups in disease course, frequency of epilepsy, status epilepticus, and the number of antiseizure medications (ASMs) used (P 0.05). Based on multivariate logistic regression analysis, the course of disease, frequency of onset, status epilepticus and number of ASMs used were identified as high-risk factors for cognitive impairment in children with epilepsy. Similarly, early onset, long course of disease, known etiology, and combination of multiple drugs have a negative impact on behavioral problems, school education, and social adaptability. Conclusion The course of disease, the frequency of onset, status epilepticus, and the number of ASMs used are high-risk factors for cognitive impairment in children with epilepsy, which can be prevented and controlled early. When selecting ASMs, their advantages and disadvantages should be weighed. Moreover, the availability of alternative treatment options must be considered. With the help of genomic technology, the causes of epilepsy should be identified as early as possible, and precision medicine and gene therapy for children with epilepsy should be actively developed.
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- 2024
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22. The potential role of hydrogen sulfide in cancer cell apoptosis
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Wei Gao, Ya-Fang Liu, Yan-Xia Zhang, Yan Wang, Yu-Qing Jin, Hang Yuan, Xiao-Yi Liang, Xin-Ying Ji, Qi-Ying Jiang, and Dong-Dong Wu
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H2S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H2S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H2S in cancer cell apoptosis in mammals are summarized.
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- 2024
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23. Pick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell
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Yu Wang, Zhi-Ying Guan, Shao-Wen Shi, Yi-Rong Jiang, Jie Zhang, Yi Yang, Qiong Wu, Jie Wu, Jian-Bo Chen, Wei-Xin Ying, Qin-Qin Xu, Qian-Xi Fan, Hui-Feng Wang, Li Zhou, Ling Wang, Jin Fang, Jian-Zhang Pan, and Qun Fang
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Science - Abstract
Abstract The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applications. Here, we develop a pick-up single-cell proteomic analysis (PiSPA) workflow to achieve a deep identification capable of quantifying up to 3000 protein groups in a mammalian cell using the label-free quantitative method. The PiSPA workflow is specially established for single-cell samples mainly based on a nanoliter-scale microfluidic liquid handling robot, capable of achieving single-cell capture, pretreatment and injection under the pick-up operation strategy. Using this customized workflow with remarkable improvement in protein identification, 2449–3500, 2278–3257 and 1621–2904 protein groups are quantified in single A549 cells (n = 37), HeLa cells (n = 44) and U2OS cells (n = 27) under the DIA (MBR) mode, respectively. Benefiting from the flexible cell picking-up ability, we study HeLa cell migration at the single cell proteome level, demonstrating the potential in practical biological research from single-cell insight.
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- 2024
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24. Combining full-length gene assay and SpliceAI to interpret the splicing impact of all possible SPINK1 coding variants
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Hao Wu, Jin-Huan Lin, Xin-Ying Tang, Gaëlle Marenne, Wen-Bin Zou, Sacha Schutz, Emmanuelle Masson, Emmanuelle Génin, Yann Fichou, Gerald Le Gac, Claude Férec, Zhuan Liao, and Jian-Min Chen
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Chronic pancreatitis ,Full-length gene splicing assay (FLGSA) ,Precision medicine in genetics ,Pre-mRNA splicing ,Single-nucleotide variants (SNVs) ,SpliceAI ,Medicine ,Genetics ,QH426-470 - Abstract
Abstract Background Single-nucleotide variants (SNVs) within gene coding sequences can significantly impact pre-mRNA splicing, bearing profound implications for pathogenic mechanisms and precision medicine. In this study, we aim to harness the well-established full-length gene splicing assay (FLGSA) in conjunction with SpliceAI to prospectively interpret the splicing effects of all potential coding SNVs within the four-exon SPINK1 gene, a gene associated with chronic pancreatitis. Results Our study began with a retrospective analysis of 27 SPINK1 coding SNVs previously assessed using FLGSA, proceeded with a prospective analysis of 35 new FLGSA-tested SPINK1 coding SNVs, followed by data extrapolation, and ended with further validation. In total, we analyzed 67 SPINK1 coding SNVs, which account for 9.3% of the 720 possible coding SNVs. Among these 67 FLGSA-analyzed SNVs, 12 were found to impact splicing. Through detailed comparison of FLGSA results and SpliceAI predictions, we inferred that the remaining 653 untested coding SNVs in the SPINK1 gene are unlikely to significantly affect splicing. Of the 12 splice-altering events, nine produced both normally spliced and aberrantly spliced transcripts, while the remaining three only generated aberrantly spliced transcripts. These splice-impacting SNVs were found solely in exons 1 and 2, notably at the first and/or last coding nucleotides of these exons. Among the 12 splice-altering events, 11 were missense variants (2.17% of 506 potential missense variants), and one was synonymous (0.61% of 164 potential synonymous variants). Notably, adjusting the SpliceAI cut-off to 0.30 instead of the conventional 0.20 would improve specificity without reducing sensitivity. Conclusions By integrating FLGSA with SpliceAI, we have determined that less than 2% (1.67%) of all possible coding SNVs in SPINK1 significantly influence splicing outcomes. Our findings emphasize the critical importance of conducting splicing analysis within the broader genomic sequence context of the study gene and highlight the inherent uncertainties associated with intermediate SpliceAI scores (0.20 to 0.80). This study contributes to the field by being the first to prospectively interpret all potential coding SNVs in a disease-associated gene with a high degree of accuracy, representing a meaningful attempt at shifting from retrospective to prospective variant analysis in the era of exome and genome sequencing.
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- 2024
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25. Two-partite entanglement purification assisted by quantum-dot spins inside single-sided optical microcavities
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Xiu, Xiao-Ming, Liu, Si-Tong, Wang, Xin-Ying, Lv, Liu, Zhao, Zi-Lin, Yuan, Zi-Qing, Chen, Si-Ge, Zhang, Xin-Yi, Yang, Zi-Long, Ji, Yan-Qiang, and Dong, Li
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- 2024
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26. The Origin of the Photospheric Emission of GRB 220426A
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Song, Xin-Ying, Zhang, Shuang-Nan, Ge, Ming-Yu, and Zhang, Shu
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRB 220426A is a bright gamma-ray burst (GRB) dominated by the photospheric emission. We perform several tests to speculate the origin of this photospheric emission. The dimensionless entropy $\eta$ is large, which is not usual if we assume that it is a pure hot fireball launched by neutrino-antineutrino annihilation mechanism only. Moreover, the outflow has larger $\eta$ with lower luminosity $L$ in the first few seconds, so that the trend of time-resolved $\eta-L$ can not be described as a monotonically positive correlation between $\eta$ and $L$. A hybrid outflow with almost completely thermalized Poynting flux could account for the quasi-thermal spectrum as well as large $\eta$. More importantly, the existence of magnetic field could affect the proton density and neutron-proton coupling effect, so that it could account for the observed trend of time-resolved $\eta-L$. The other origins for the photospheric emission, such as non-dissipative hybrid outflow or magnetic reconnection, are not supported because their radiation efficiencies are low, which is not consistent with non-detection of the afterglow for GRB 220426A. Therefore, we think the hybrid outflow may be the most likely origin., Comment: 15 pages, 7 figures, published in MNRAS
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- 2022
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27. MAFormer: A Transformer Network with Multi-scale Attention Fusion for Visual Recognition
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Wang, Yunhao, Sun, Huixin, Wang, Xiaodi, Zhang, Bin, Li, Chao, Xin, Ying, Zhang, Baochang, Ding, Errui, and Han, Shumin
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Vision Transformer and its variants have demonstrated great potential in various computer vision tasks. But conventional vision transformers often focus on global dependency at a coarse level, which suffer from a learning challenge on global relationships and fine-grained representation at a token level. In this paper, we introduce Multi-scale Attention Fusion into transformer (MAFormer), which explores local aggregation and global feature extraction in a dual-stream framework for visual recognition. We develop a simple but effective module to explore the full potential of transformers for visual representation by learning fine-grained and coarse-grained features at a token level and dynamically fusing them. Our Multi-scale Attention Fusion (MAF) block consists of: i) a local window attention branch that learns short-range interactions within windows, aggregating fine-grained local features; ii) global feature extraction through a novel Global Learning with Down-sampling (GLD) operation to efficiently capture long-range context information within the whole image; iii) a fusion module that self-explores the integration of both features via attention. Our MAFormer achieves state-of-the-art performance on common vision tasks. In particular, MAFormer-L achieves 85.9$\%$ Top-1 accuracy on ImageNet, surpassing CSWin-B and LV-ViT-L by 1.7$\%$ and 0.6$\%$ respectively. On MSCOCO, MAFormer outperforms the prior art CSWin by 1.7$\%$ mAPs on object detection and 1.4$\%$ on instance segmentation with similar-sized parameters, demonstrating the potential to be a general backbone network., Comment: 9 pages, 2 figures
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- 2022
28. Causal association of juvenile idiopathic arthritis or JIA-associated uveitis and gut microbiota: a bidirectional two-sample Mendelian randomisation study
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Jun-bin Hong, Yue-xuan Chen, Zhi-ying Su, Xin-ying Chen, Yan-ni Lai, and Jing-hua Yang
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juvenile idiopathic arthritis ,uveitis ,gut microbiota ,causality ,bidirectional ,Mendelian randomisation analysis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundThe gut microbiota significantly influences the onset and progression of juvenile idiopathic arthritis (JIA) and associated uveitis (JIAU); however, the causality remains unclear. This study aims to establish a causal link between gut microbiota and JIA or JIAU.MethodsUsing publicly available genome-wide association studies (GAWS) summary data, we conducted a two-sample Mendelian randomisation (MR) analysis employing various methods, namely inverse variance weighted (IVW), simple mode, weighted mode, weighted median and MR-Egger regression methods, to assess the causal association between JIA or JIAU and gut microbiota. Sensitivity analyses, including Cochrane’s Q test, MR-Egger intercept test, leave-one-out analysis and MR-PRESSO, were performed to evaluate the robustness of the MR results. Subsequently, reverse MR analysis was conducted to determine causality between gene-predicted gut microbiota abundance and JIA or JIAU.ResultsThe MR analysis revealed a causal association between gut microbiota abundance variations and JIA or JIAU risk. Specifically, the increased abundance of genus Ruminococcaceae UCG013 (OR: 0.055, 95%CI: 0.006–0.103, p = 0.026) and genus Ruminococcaceae UCG003 (β: 0.06, 95%CI: 0.003–0.117, p = 0.041) correlated with an increased risk of JIA, while genus Lachnospiraceae UCG001 (OR: 0.833, 95%CI: 0.699~0.993, p = 0.042) was associated with a reduced risk of JIA, among others. Sensitivity analysis confirmed MR analysis robustness.ConclusionsThis study provides substantial evidence supporting a causal association between genetically predicted gut microbiota and JIA or JIAU. It highlights the significant role of intestinal flora in JIA or JIAU development, suggesting their potential as novel biomarkers for diagnosis and prevention. These findings offer valuable insights to mitigate the impact of JIA or JIAU.
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- 2024
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29. Heteroepitaxially grown homojunction gallium oxide PN diodes using ion implantation technologies
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Chih-Yang Huang, Xin-Ying Tsai, Fu-Gow Tarntair, Catherine Langpoklakpam, Thien Sao Ngo, Pei-Jung Wang, Yu-Cheng Kao, Yi-Kai Hsiao, Niall Tumilty, Hao-Chung Kuo, Tian-Li Wu, Ching-Lien Hsiao, and Ray-Hua Horng
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Although advancements in n- and p-doping of gallium oxide (Ga2O3) are underway, the realization of functional pn diodes remains elusive. Here, we present the successful fabrication of a Ga2O3 pn diode utilizing ion implantation technology. The Ga2O3 epilayers were grown on c-plane sapphire substrates by metalorganic chemical vapor deposition (MOCVD). P-type conductivity Ga2O3 epilayer, confirmed by Hall effect analysis, was achieved by phosphorus (P) ion implantation followed with a rapid thermal annealing (RTA) process. This p-Ga2O3 epilayer reveals a significant reduction in resistivity ( 3kT/q) and remained very low at 2✕10−8 A, as the diode operated at 150oC. The behavior could be due to Ga2O3 being a wide bandgap material.
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- 2024
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30. Functional role of autophagy in testicular and ovarian steroidogenesis
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Ali Afzal, Yue Zhang, Hanan Afzal, Umair Ali Khan Saddozai, Lei Zhang, Xin-Ying Ji, and Muhammad Babar Khawar
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autophagy ,testicular steroidogenesis ,ovarian steroidogenesis ,testosterone ,progesterone ,Biology (General) ,QH301-705.5 - Abstract
Autophagy is an evolutionarily conserved cellular recycling process that maintains cellular homeostasis. Despite extensive research in endocrine contexts, the role of autophagy in ovarian and testicular steroidogenesis remains elusive. The significant role of autophagy in testosterone production suggests potential treatments for conditions like oligospermia and azoospermia. Further, influence of autophagy in folliculogenesis, ovulation, and luteal development emphasizes its importance for improved fertility and reproductive health. Thus, investigating autophagy in gonadal cells is clinically significant. Understanding these processes could transform treatments for endocrine disorders, enhancing reproductive health and longevity. Herein, we provide the functional role of autophagy in testicular and ovarian steroidogenesis to date, highlighting its modulation in testicular steroidogenesis and its impact on hormone synthesis, follicle development, and fertility therapies.
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- 2024
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31. Identification and targeting of a SOX2 and SOX9 degradation pathway in glioblastoma
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Yeo, Xin ying, Pollard, Steven, and Carragher, Neil
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SOX2 ,SOX9 ,degradation pathway ,Glioblastoma multiforme ,glioblastoma stem cells ,neural stem cells ,neurodevelopmental transcription factors ,ubiquitin-proteasome system - Abstract
Glioblastoma multiforme (GBM) is the most malignant adult brain tumour. A subpopulation of cells, termed glioblastoma stem cells (GSCs), possesses similar phenotypic characteristics to normal neural stem cells (NSCs) and may drive tumorigenesis. GSCs frequently express many essential neurodevelopmental transcription factors (TFs) at high levels. Of particular note are SOX2 and SOX9 genes, which are master regulatory TFs in the forebrain development with reprogramming activity that are essential for GSC self-renewal. Here we explored a set of newly identified small-molecule compounds that was shortlisted following phenotypic screening for loss of SOX2 in GSCs. We showed that a subset of these hits operates via the ubiquitin-proteasome system (UPS), revealing a potentially new pathway controlling SOX2 and SOX9 protein turnover. We demonstrated that these compounds likely act through a class of enzymes called deubiquitylases (DUBs). The lead compound 1035 was validated across a range of different patient models using two orthogonal reporter lines. We also confirmed that the endogenous protein was degraded via a proteasomal mediated pathway. We explored the selectivity of effects on cell viability and proliferation using an independent panel of non-GBM cell lines, including human umbilical vein endothelial cells, fibroblasts, non-tumour pericyte-like cells as well as human pluripotent stem cells (hPSCs)-derived neuroepithelial. The compound appeared selective, yet had some degree of off-target toxicities at higher doses. However, we did notice a strikingly significant positive correlation between the effect on GSC proliferation and SOX2/SOX9 expression levels. USP36, USP39 and USP42 were determined as potential DUB targets to which 1035 might bind, based on their restricted subcellular localisation to the nuclear/nucleolar compartments, in addition to lower SOX2/SOX9 abundance after individual knockdown. Concurrent deletion of these USPs was also able to phenocopy the compound effects, with diminished cell viability as well as proliferative arrest, alongside a robust SOX2 and SOX9 protein decline. Next, four structural analogues of 1035 were significantly less effective in overall at reducing endogenous SOX2 and SOX9, implying that the presence of a chiral carbon atom or/and methyl group at the asymmetrical carbon position is/are absolutely critical to retain compound activity. Individually purified R or S enantiomer was unexpectedly less potent than the original 1035, but this was restored in a racemic mixture, consistent with both enantiomers possibly operating together with a concerted synergism. The right-handed stereoisomer R mainly facilitated SOX2 and SOX9 protein degradation via USP42 (and maybe USP36 to a limited extent); meanwhile the left-handed stereoisomer S gave rise to broad cytotoxicity via nucleolar disruption pathway in a non-cell-selective manner. The structure-activity relationship can then be applied for future medicinal chemistry optimisation to improve lead compound potency and on-target specificity, whilst minimising the non-selective killing impact on normal human cells.
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- 2023
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32. Brand hate in the cosmetic industry: drugstore versus luxury make-up brands
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Xin Ying Ong, Sharon and Vila-Lopez, Natalia
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- 2024
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33. Circular RNA circ_KIAA1429 accelerates hepatocellular carcinoma progression via the miR-133a-3p/high mobility group AT-hook 2 (HMGA2) axis in an m6A-dependent manner
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Zhang, Chun-Peng and Huang, Xin-Ying
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- 2023
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34. Energy analysis of the extrusion process through a streamlined Gaussian die
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Zhang, Shun Hu, Zhang, Yi, and Liu, Xin Ying
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- 2023
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35. Genome-wide identification and expression analysis of SnRK2 gene family in common bean (Phaseolus vulgaris L.) in response to abiotic stress
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Cai, De-Bao, Sun, Xin-Ying, Zhang, Yu-Peng, Yang, Shu-Qiong, Zhang, Jun, and Chen, Ji-Bao
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- 2023
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36. Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia
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Xin Ying Chua, Federico Torta, Joyce R. Chong, Narayanaswamy Venketasubramanian, Saima Hilal, Markus R. Wenk, Christopher P. Chen, Thiruma V. Arumugam, Deron R. Herr, and Mitchell K. P. Lai
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Alzheimer’s disease ,Biomarkers ,Lipidomics ,Sphingolipids ,Vascular dementia ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Alzheimer’s disease (AD) and vascular dementia (VaD) are two of the commonest causes of dementia in the elderly. Of the myriad biomolecules implicated in dementia pathogenesis, sphingolipids have attracted relatively scant research attention despite their known involvement in multiple pathophysiological processes. The potential utility of peripheral sphingolipids as biomarkers in dementia cohorts with high concomitance of cerebrovascular diseases is also unclear. Methods Using a lipidomics platform, we performed a case–control study of plasma sphingolipids in a prospectively assessed cohort of 526 participants (non-cognitively impaired, NCI = 93, cognitively impaired = 217, AD = 166, VaD = 50) using a lipidomics platform. Results Distinct patterns of sphingolipid alterations were found in AD and VaD, namely an upregulation of d18:1 species in AD compared to downregulation of d16:1 species in VaD. In particular, GM3 d18:1/16:0 and GM3 d18:1/24:1 showed the strongest positive associations with AD. Furthermore, evaluation of sphingolipids panels showed specific combinations with higher sensitivity and specificity for classification of AD (Cer d16:1/24:0. Cer d18:1/16:0, GM3 d16:1/22:0, GM3 d18:1/16:0, SM d16:1/22:0, HexCer d18:1/18:0) and VAD (Cer d16:1/24:0, Cer d18:1/16:0, Hex2Cer d16:1/16:0, HexCer d18:1/18:0, SM d16:1/16:0, SM d16:1/20:0, SM d18:2/22:0) compared to NCI. Conclusions AD and VaD are associated with distinct changes of plasma sphingolipids, warranting further studies into underlying pathophysiological mechanisms and assessments of their potential utility as dementia biomarkers and therapeutic targets.
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- 2023
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37. A pan-cancer analysis of Dyskeratosis congenita 1 (DKC1) as a prognostic biomarker
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Xin-ying Liu, Qing Tan, and Lin-xiao Li
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DKC1 ,Pan-cancer ,Prognosis ,Enrichment analysis ,Cell proliferation ,Genetics ,QH426-470 - Abstract
Abstract Background Dyskeratosis congenita 1 (DKC1), a critical component of telomerase complex, is highly expressed in a variety of human cancers. However, the association of DKC1 with cancer occurrence and development stages is not clear, making a pan-cancer analysis crucial. Methods We conducted a study using various bioinformatic databases such as TIMER, GEPIA, UALCAN, and KM plotter Analysis to examine the different expressions of DKC1 in multiple tissues and its correlation with pathological stages. Through KEGG analysis, GO enrichment analysis and Venn analysis, we were able to reveal DKC1-associated genes and signaling pathways. In addition, we performed several tests including the CCK, wound healing assay, cell cycle arrest assay, transwell assay and Sa-β-gal staining on DKC1-deleted MDA-231 cells. Results Our study demonstrates that DKC1 has relatively low expression specificity in different tissues. Furthermore, we found that in ACC, KICH, KIRP and LIHC, the expression level of DKC1 is positively correlated with pathological stages. Conversely, in NHSC, KIRP, LGG, LIHC, MESO and SARC, we observed a negative influence of DKC1 expression level on the overall survival rate. We also found a significant positive correlation between DKC1 expression and Tumor Mutational Burden in 14 tumors. Additionally, we observed a significantly negative impact of DKC1 DNA methylation on gene expression at the promoter region in BRCA. We also identified numerous phosphorylation sites concentrated at the C-terminus of the DKC1 protein. Our GO analysis revealed a correlation between DKC1 and ribosomal biosynthesis pathways, and the common element UTP14A was identified. We also observed decreased rates of cell proliferation, migration and invasion abilities in DKC1-knockout MDA-MB-231 cell lines. Furthermore, DKC1-knockout induced cell cycle arrest and caused cell senescence. Conclusions Our findings suggest that the precise expression of DKC1 is closely associated with the occurrence and developmental stages of cancer in multiple tissues. Depletion of DKC1 can inhibit the abilities of cancer cells to proliferate, migrate, and invade by arresting the cell cycle and inducing cell senescence. Therefore, DKC1 may be a valuable prognostic biomarker for the diagnosis and treatment of cancer in various tissues.
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- 2023
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38. GRB 210121A: Observation of photospheric emissions from different regimes and the evolution of the outflow
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Song, Xin-Ying, Zhang, Shuang-Nan, Zhang, Shu, Xiong, Shao-Lin, and Song, Li-Ming
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRB 210121A was observed by Insight-HXMT, Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM), Fermi Gamma-ray Burst Monitor (Fermi/GBM) on Jan 21st 2021. In this work, photospheric emission from a structured jet is preferred to interpret the prompt emission phase of GRB 210121A and emissions from different regimes are observed on-axis. Particularly, the emission from the intermediate photosphere is first observed in the first 1.3 s of the prompt emission, while those from the other part are dominant by the saturated regime, and offers an alternative explanation compared with the previous work. Moreover, the emissions with considering the intermediate photosphere can well interpret the changes on low-energy photon index $\alpha$ during the pulses. Besides, the evolution of the outflow is extracted from time-resolved analysis, and a correlation of $\Gamma_0 \propto L^{0.25\pm0.05}_0$ is obtained, which implies that the jet may be mainly launched by neutrino annihilation in a hyper-accretion disk., Comment: 10 pages, 4 figures, published The ApJ, 931:112 (7pp), 2022 June 1
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- 2022
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39. The Hardness-intensity Correlation of Photospheric Emission from a Structured Jet for Gamma-Ray Bursts
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Song, Xin-Ying and Meng, Yan-Zhi
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
For many gamma-ray bursts (GRBs), hardness-intensity correlation (HIC) can be described by a power-law function, $E_{\rm p}\propto F^{\kappa}$, where $E_{\rm p}$ is the peak energy of $\nu F_{\nu}$ spectrum, and $F$ is the instantaneous energy flux. In this paper, HIC of the non-dissipative photospheric emission from a structured jet is studied in different regimes. An intermediate photosphere, which contains both of unsaturated and saturated emissions is introduced, and we find positive $\kappa<1/4$ in this case. The same conclusion could be generalized to the photospheric emission from a hybrid jet without magnetic dissipations, or that with sub-photospheric magnetic dissipations and fully thermalized. This may imply that the contribution peaking at $\sim1/2$ in the distribution of observed $\kappa$ are mainly from the prompt emission of GRBs with synchrotron origin. Besides, emissions of the intermediate photosphere could give a smaller low-energy photon index $\alpha$ than that in the unsaturated regime, and naturally reproduce anti-correlation in $\alpha-E_{\rm p}$ in a GRB pulse., Comment: 8 pages, 10 figures, published in MNRAS
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- 2022
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40. The First Insight-HXMT Gamma-Ray Burst Catalog: The First Four Years
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Song, Xin-Ying, Xiong, Shao-Lin, Zhang, Shuang-Nan, Li, Cheng-Kui, Li, Xiao-Bo, Huang, Yue, Guidorzi, Cristiano, Frontera, Filippo, Liu, Cong-Zhan, Li, Xu-Fang, Li, Gang, Liao, Jin-Yuan, Cai, Ce, Luo, Qi, Xiao, Shuo, Yi, Qi-Bin, Zheng, Yao-Guang, Zhou, Deng-Ke, Liu, Jia-Cong, Xue, Wang-Chen, Zhang, Yan-Qiu, Zheng, Chao, Chang, Zhi, Li, Zheng-Wei, Lu, Xue-Feng, Zhang, Ai-Mei, Zhang, Yi-Fei, Jin, Yong-Jie, Li, Ti-Pei, Lu, Fang-Jun, Song, Li-Ming, Wu, Mei, Xu, Yu-Peng, Ma, Xiang, Ge, Ming-Yu, Jia, Shu-Mei, Li, Bing, Nie, Jian-Yin, Wang, Ling-Jun, Zhang, Juan, Zheng, Shi-Jie, Yang, Xue-Juan, and Yang, Rong-Jia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Hard X-ray Modulation Telescope (Insight-HXMT), is China's first X-ray astronomy satellite launched on June 15, 2017. The anti-coincidence CsI detectors of the High Energy X-ray telescope (HE) onboard Insight-HXMT could serve as an all-sky gamma-ray monitor in about 0.2-3 MeV. In its first four years of operation, Insight-HXMT has detected 322 Gamma-Ray Bursts (GRBs) by offline search pipeline including blind search and targeted search. For the GOLDEN sample of Insight-HXMT GRBs, joint analyses were performed with other GRB missions, including Fermi Gamma-ray Burst Monitor (Fermi/GBM), Swift Burst Alert Telescope (Swift/BAT) and Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM). It shows that Insight-HXMT can provide better constraint on GRB spectrum at higher energy band. The properties of Insight-HXMT GRBs are reported in detail, including their trigger time, duration, spectral parameters, peak fluxes of different time scales and fluence. This catalog is an official product of the Insight-HXMT GRB team., Comment: 46 pages, 22 figures, accepted by APJS
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- 2022
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41. Context Autoencoder for Self-Supervised Representation Learning
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Chen, Xiaokang, Ding, Mingyu, Wang, Xiaodi, Xin, Ying, Mo, Shentong, Wang, Yunhao, Han, Shumin, Luo, Ping, Zeng, Gang, and Wang, Jingdong
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Computer Science - Computer Vision and Pattern Recognition - Abstract
We present a novel masked image modeling (MIM) approach, context autoencoder (CAE), for self-supervised representation pretraining. We pretrain an encoder by making predictions in the encoded representation space. The pretraining tasks include two tasks: masked representation prediction - predict the representations for the masked patches, and masked patch reconstruction - reconstruct the masked patches. The network is an encoder-regressor-decoder architecture: the encoder takes the visible patches as input; the regressor predicts the representations of the masked patches, which are expected to be aligned with the representations computed from the encoder, using the representations of visible patches and the positions of visible and masked patches; the decoder reconstructs the masked patches from the predicted encoded representations. The CAE design encourages the separation of learning the encoder (representation) from completing the pertaining tasks: masked representation prediction and masked patch reconstruction tasks, and making predictions in the encoded representation space empirically shows the benefit to representation learning. We demonstrate the effectiveness of our CAE through superior transfer performance in downstream tasks: semantic segmentation, object detection and instance segmentation, and classification. The code will be available at https://github.com/Atten4Vis/CAE., Comment: Accepted by International Journal of Computer Vision (IJCV)
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- 2022
42. Technological diversity in the tropical-subtropical zone of Southwest China during the terminal Pleistocene: excavations at Fodongdi Cave
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Huan, Fa-Xiang, Yang, Shi-Xia, Gao, Feng, Zhou, Xin-Ying, Yue, Jian-Ping, Zhang, Yu-Xiu, Wu, Jin-Xu, Ruan, Qi-Jun, Qiu, Kai-Wei, Xu, Jing-wen, Lin, Nai-Ru, Wang, Yi-Ren, Pei, Shu-Wen, Zhao, Ke-Liang, Petraglia, Michael, and Li, Xiao-Qiang
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- 2024
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43. Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia
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Chua, Xin Ying, Torta, Federico, Chong, Joyce R., Venketasubramanian, Narayanaswamy, Hilal, Saima, Wenk, Markus R., Chen, Christopher P., Arumugam, Thiruma V., Herr, Deron R., and Lai, Mitchell K. P.
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- 2023
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44. A pan-cancer analysis of Dyskeratosis congenita 1 (DKC1) as a prognostic biomarker
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Liu, Xin-ying, Tan, Qing, and Li, Lin-xiao
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- 2023
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45. Characteristics and prognostic implications of peripheral blood lymphocyte subsets in patients with anti-MDA5 antibody positive dermatomyositis-interstitial lung disease
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Ren, Fang-Ping, Chen, Qi, Yao, Shan-Shan, Feng, Lin, Xue, Xin-Ying, Zhao, Wei-Chao, Wang, Dong, Zhao, Zhi-Ling, Gu, Si-Wei, Li, Ting, Shen, Ya-Wen, Gao, Lan, Zang, Xue-Lei, Bao, Xin-Yu, and Tong, Zhao-Hui
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- 2023
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46. Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms
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Wang, Bin, Han, Yin, Zhang, Yuyu, Zhao, Qin, Wang, Huanhuan, Wei, Jinlong, Meng, Lingbin, Xin, Ying, and Jiang, Xin
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- 2023
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47. Ultrastable Co-NC membrane for sterilization of Escherichia coli in flowing water
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Li, Chao, Li, Jiale, Huang, Niu, Kong, Xin Ying, Xiao, Qingyi, Huang, Yingping, Wong, Po Keung, and Ye, Liqun
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- 2023
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48. Assessment of COVID-19 Positive Rates Amongst COVID-19 Close Contacts Through the Health Risk Warning System
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Chong, Si Jack, Seah, Benjamin ZQ, Jailani, Rehmen I, Angeles, Dario C, Chong, Xin Ying, and Lee, Joan Hin
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- 2023
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49. Eight-and-a-half syndrome as the first presentation of multiple sclerosis in an Asian male: a case report
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Lim, Xin Ying, Wai, Yong Zheng, Yong, Yun Xiu, and Lim, Lik Thai
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- 2023
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50. COVID-19 Close Contact Management: An Evolution of Operations Harnessing the Digital Edge
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Seah, Benjamin ZQ, Jailani, Rehmen I, Law, Peter YC, Teo, Roger SM, Chong, Xin Ying, Law, Olivia, and Chong, Si Jack
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- 2023
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