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7. Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial

Author

Koopman, Inez, primary, Tack, Reinier WP, additional, Wunderink, Herman F, additional, Bruns, Anke HW, additional, van der Schaaf, Irene C, additional, Cianci, Daniela, additional, Gelderman, Kyra A, additional, van de Ridder, Inge M, additional, Hol, Elly M, additional, Rinkel, Gabriel JE, additional, and Vergouwen, Mervyn DI, additional

Published
2023
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9. Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave:a multicentre cross-sectional study with prospective follow-up

Author

Recanatini, Claudia, GeurtsvanKessel, Corine, Pas, Suzan, Broens, Els, Maas, Martje, van Mansfeld, Rosa, Mutsaers-van Oudheusden, Anne J.G., van Rijen, Miranda, Schippers, Emile, Stegeman, Arjan, Tami, Adriana, Veldkamp, Karin Ellen, Visser, Hannah, Voss, Andreas, Wegdam-Blans, Marjolijn, Wertheim, Heiman F.L., Wever, Peter, Koopmans, Marion, Kluytmans, Jan A.J.W., Kluytmans-van den Bergh, Marjolein F.Q., Bergmans, Anneke, van den Bijllaardt, Wouter, Buiting, Anton, Dohmen, Wietske, Friedrich, Alexander, van der Gun, Bernardina, Heederik, Dick, de Jong, Menno, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, Meijer, Angelique, Murk, Jean Luc, Nabuurs, Marrigje, Niesters, Bert, ten Oever, Jaap, Mutsaers-van Oudheusden, Anne, Schweitzer, Valentijn, Streefkerk, Roel, Veloo, Alida, de Vries, Jutte, Wold, Karin, Wunderink, Herman, Recanatini, Claudia, GeurtsvanKessel, Corine, Pas, Suzan, Broens, Els, Maas, Martje, van Mansfeld, Rosa, Mutsaers-van Oudheusden, Anne J.G., van Rijen, Miranda, Schippers, Emile, Stegeman, Arjan, Tami, Adriana, Veldkamp, Karin Ellen, Visser, Hannah, Voss, Andreas, Wegdam-Blans, Marjolijn, Wertheim, Heiman F.L., Wever, Peter, Koopmans, Marion, Kluytmans, Jan A.J.W., Kluytmans-van den Bergh, Marjolein F.Q., Bergmans, Anneke, van den Bijllaardt, Wouter, Buiting, Anton, Dohmen, Wietske, Friedrich, Alexander, van der Gun, Bernardina, Heederik, Dick, de Jong, Menno, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, Meijer, Angelique, Murk, Jean Luc, Nabuurs, Marrigje, Niesters, Bert, ten Oever, Jaap, Mutsaers-van Oudheusden, Anne, Schweitzer, Valentijn, Streefkerk, Roel, Veloo, Alida, de Vries, Jutte, Wold, Karin, and Wunderink, Herman

Abstract

Background: We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. Methods: HCWs from 13 Dutch hospitals were screened for antibodies against the spike protein of SARS-CoV-2 in June-July 2020 and after three months. Participants completed a retrospective questionnaire on determinants for occupational and community exposure to SARS-CoV-2 and symptoms suggestive of COVID-19 experienced since January 2020. The seroprevalence was calculated per baseline characteristic and symptom at baseline and after follow-up. Adjusted odds ratios (aOR) for seropositivity were determined using logistic regression. Results: Among 2328 HCWs, 323 (13.9%) were seropositive at enrolment, 49 of whom (15%) reported no previous symptoms suggestive of COVID-19. During follow-up, only 1% of the tested participants seroconverted. Seroprevalence was higher in younger HCWs compared to the mid-age category (aOR 1.53, 95% CI 1.07–2.18). Nurses (aOR 2.21, 95% CI 1.34–3.64) and administrative staff (aOR 1.87, 95% CI 1.02–3.43) had a higher seroprevalence than physicians. The highest seroprevalence was observed in HCWs in the emergency department (ED) (aOR 1.79, 95% CI 1.10–2.91), the lowest in HCWs in the intensive, high, or medium care units (aOR 0.47, 95% CI 0.31–0.71). Chronic respiratory disease, smoking, and having a dog were independently associated with a lower seroprevalence, while HCWs with diabetes mellitus had a higher seroprevalence. In a multivariable model containing all self-reported symptoms since January 2020, altered smell and taste, fever, general malaise/fatigue, and muscle aches were positively associated with developing antibodies, while sore throat and chills were negatively associated. 'Conclusions: The SARS-CoV-2 serop

Published
2023

10. Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial

Author

Opleiding Neurologie, Projectafdeling CVZ, MMB opleiding Arts microbioloog, Infection & Immunity, MS Radiologie, Brain, Circulatory Health, CTM & Statistical consultation, Translational Neuroscience, Cancer, Neurologen, Koopman, Inez, Tack, Reinier Wp, Wunderink, Herman F, Bruns, Anke Hw, van der Schaaf, Irene C, Cianci, Daniela, Gelderman, Kyra A, van de Ridder, Inge M, Hol, Elly M, Rinkel, Gabriel Je, Vergouwen, Mervyn DI, Opleiding Neurologie, Projectafdeling CVZ, MMB opleiding Arts microbioloog, Infection & Immunity, MS Radiologie, Brain, Circulatory Health, CTM & Statistical consultation, Translational Neuroscience, Cancer, Neurologen, Koopman, Inez, Tack, Reinier Wp, Wunderink, Herman F, Bruns, Anke Hw, van der Schaaf, Irene C, Cianci, Daniela, Gelderman, Kyra A, van de Ridder, Inge M, Hol, Elly M, Rinkel, Gabriel Je, and Vergouwen, Mervyn DI

Published
2023

11. Disseminated nontuberculous mycobacterial infections after allogeneic hematopoietic stem cell transplantation: a risk-based strategy for early diagnosis

Author

MS Hematologie, Cancer, MMB Medische Staf, Infection & Immunity, Pathologie Pathologen staf, MMB opleiding Arts microbioloog, CTI De Witte, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, CTI Kuball, Daenen, Laura G M, van der Bruggen, Jan-Tom, Leguit, Roos J, van der Wagen, Lotte E, van Rhenen, Anna, Wunderink, Herman F, de Witte, Moniek A, Bruns, Anke H W, Kuball, Jurgen, MS Hematologie, Cancer, MMB Medische Staf, Infection & Immunity, Pathologie Pathologen staf, MMB opleiding Arts microbioloog, CTI De Witte, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, CTI Kuball, Daenen, Laura G M, van der Bruggen, Jan-Tom, Leguit, Roos J, van der Wagen, Lotte E, van Rhenen, Anna, Wunderink, Herman F, de Witte, Moniek A, Bruns, Anke H W, and Kuball, Jurgen

Published
2023

15. Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin

Author

Spaan, András N., primary, Neehus, Anna-Lena, additional, Laplantine, Emmanuel, additional, Staels, Frederik, additional, Ogishi, Masato, additional, Seeleuthner, Yoann, additional, Rapaport, Franck, additional, Lacey, Keenan A., additional, Van Nieuwenhove, Erika, additional, Chrabieh, Maya, additional, Hum, David, additional, Migaud, Mélanie, additional, Izmiryan, Araksya, additional, Lorenzo, Lazaro, additional, Kochetkov, Tatiana, additional, Heesterbeek, Dani A. C., additional, Bardoel, Bart W., additional, DuMont, Ashley L., additional, Dobbs, Kerry, additional, Chardonnet, Solenne, additional, Heissel, Søren, additional, Baslan, Timour, additional, Zhang, Peng, additional, Yang, Rui, additional, Bogunovic, Dusan, additional, Wunderink, Herman F., additional, Haas, Pieter-Jan A., additional, Molina, Henrik, additional, Van Buggenhout, Griet, additional, Lyonnet, Stanislas, additional, Notarangelo, Luigi D., additional, Seppänen, Mikko R. J., additional, Weil, Robert, additional, Seminario, Gisela, additional, Gomez-Tello, Héctor, additional, Wouters, Carine, additional, Mesdaghi, Mehrnaz, additional, Shahrooei, Mohammad, additional, Bossuyt, Xavier, additional, Sag, Erdal, additional, Topaloglu, Rezan, additional, Ozen, Seza, additional, Leavis, Helen L., additional, van Eijk, Maarten M. J., additional, Bezrodnik, Liliana, additional, Blancas Galicia, Lizbeth, additional, Hovnanian, Alain, additional, Nassif, Aude, additional, Bader-Meunier, Brigitte, additional, Neven, Bénédicte, additional, Meyts, Isabelle, additional, Schrijvers, Rik, additional, Puel, Anne, additional, Bustamante, Jacinta, additional, Aksentijevich, Ivona, additional, Kastner, Daniel L., additional, Torres, Victor J., additional, Humblet-Baron, Stéphanie, additional, Liston, Adrian, additional, Abel, Laurent, additional, Boisson, Bertrand, additional, and Casanova, Jean-Laurent, additional

Published
2022
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16. Reliability and validity of multicentre surveillance of surgical site infections after colorectal surgery.

Author

Verberk, Janneke D M, van Rooden, Stephanie M, Hetem, David J, Wunderink, Herman F, Vlek, Anne L M, Meijer, Corianne, van Ravensbergen, Eva A H, Huijskens, Elisabeth G W, Vainio, Saara J, Bonten, Marc J M, van Mourik, Maaike S M, Verberk, Janneke D M, van Rooden, Stephanie M, Hetem, David J, Wunderink, Herman F, Vlek, Anne L M, Meijer, Corianne, van Ravensbergen, Eva A H, Huijskens, Elisabeth G W, Vainio, Saara J, Bonten, Marc J M, and van Mourik, Maaike S M

Published
2022

17. A dynamic flow model mimicking duodenoscope reprocessing after bacterial contamination for translational research

Author

MMB opleiding Arts microbioloog, MMB Medische Staf, Infection & Immunity, MS MDL 1, Cancer, Heuvelmans, Maarten, Woudstra, Willem, Wunderink, Herman F, Monkelbaan, Jan F, van der Mei, Henny C, MMB opleiding Arts microbioloog, MMB Medische Staf, Infection & Immunity, MS MDL 1, Cancer, Heuvelmans, Maarten, Woudstra, Willem, Wunderink, Herman F, Monkelbaan, Jan F, and van der Mei, Henny C

Published
2022

18. Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal a-toxin

Author

MMB, Infection & Immunity, Immuno/reuma patientenzorg, MMB Research line 1, MMB Medische Staf, MS Reumatologie/Immunologie/Infectie, Medische Staf Intensive Care, Spaan, András N., Neehus, Anna Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A., Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A.C., Bardoel, Bart W., DuMont, Ashley L., Dobbs, Kerry, Chardonnet, Solenne, Heissel, Søren, Baslan, Timour, Zhang, Peng, Yang, Rui, Bogunovic, Dusan, Wunderink, Herman F., Haas, Pieter Jan A., Molina, Henrik, Van Buggenhout, Griet, Lyonnet, Stanislas, Notarangelo, Luigi D., Seppänen, Mikko R.J., Weil, Robert, Seminario, Gisela, Gomez-Tello, Héctor, Wouters, Carine, Mesdaghi, Mehrnaz, Shahrooei, Mohammad, Bossuyt, Xavier, Sag, Erdal, Topaloglu, Rezan, Ozen, Seza, Leavis, Helen L., van Eijk, Maarten M.J., Bezrodnik, Liliana, Galicia, Lizbeth Blancas, Hovnanian, Alain, Nassif, Aude, Bader-Meunier, Brigitte, Neven, Bénédicte, Meyts, Isabelle, Schrijvers, Rik, Puel, Anne, Bustamante, Jacinta, Aksentijevich, Ivona, Kastner, Daniel L., Torres, Victor J., Humblet-Baron, Stéphanie, Liston, Adrian, Abel, Laurent, Boisson, Bertrand, Casanova, Jean Laurent, MMB, Infection & Immunity, Immuno/reuma patientenzorg, MMB Research line 1, MMB Medische Staf, MS Reumatologie/Immunologie/Infectie, Medische Staf Intensive Care, Spaan, András N., Neehus, Anna Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A., Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A.C., Bardoel, Bart W., DuMont, Ashley L., Dobbs, Kerry, Chardonnet, Solenne, Heissel, Søren, Baslan, Timour, Zhang, Peng, Yang, Rui, Bogunovic, Dusan, Wunderink, Herman F., Haas, Pieter Jan A., Molina, Henrik, Van Buggenhout, Griet, Lyonnet, Stanislas, Notarangelo, Luigi D., Seppänen, Mikko R.J., Weil, Robert, Seminario, Gisela, Gomez-Tello, Héctor, Wouters, Carine, Mesdaghi, Mehrnaz, Shahrooei, Mohammad, Bossuyt, Xavier, Sag, Erdal, Topaloglu, Rezan, Ozen, Seza, Leavis, Helen L., van Eijk, Maarten M.J., Bezrodnik, Liliana, Galicia, Lizbeth Blancas, Hovnanian, Alain, Nassif, Aude, Bader-Meunier, Brigitte, Neven, Bénédicte, Meyts, Isabelle, Schrijvers, Rik, Puel, Anne, Bustamante, Jacinta, Aksentijevich, Ivona, Kastner, Daniel L., Torres, Victor J., Humblet-Baron, Stéphanie, Liston, Adrian, Abel, Laurent, Boisson, Bertrand, and Casanova, Jean Laurent

Published
2022

19. Reliability and validity of multicentre surveillance of surgical site infections after colorectal surgery

Author

MMB Onderzoek en Onderwijs, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Infection & Immunity, Epi Infectieziekten, MMB opleiding Arts microbioloog, Verberk, Janneke D.M., van Rooden, Stephanie M., Hetem, David J., Wunderink, Herman F., Vlek, Anne L.M., Meijer, Corianne, van Ravensbergen, Eva A.H., Huijskens, Elisabeth G.W., Vainio, Saara J., Bonten, Marc J.M., van Mourik, Maaike S.M., MMB Onderzoek en Onderwijs, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Infection & Immunity, Epi Infectieziekten, MMB opleiding Arts microbioloog, Verberk, Janneke D.M., van Rooden, Stephanie M., Hetem, David J., Wunderink, Herman F., Vlek, Anne L.M., Meijer, Corianne, van Ravensbergen, Eva A.H., Huijskens, Elisabeth G.W., Vainio, Saara J., Bonten, Marc J.M., and van Mourik, Maaike S.M.

Published
2022

21. Human polyomavirus 9 infection in kidney transplant patients

Author

van der Meijden, Els, Wunderink, Herman F., van der Blij-de Brouwer, Caroline S., Zaaijer, Hans L., Rotmans, Joris I., Bavinck, Jan Nico Bouwes, and Feltkamp, Mariet C.W.

Subjects
Kidneys -- Transplantation, DNA -- Health aspects -- Analysis, Infection -- Health aspects -- Analysis, Health
Abstract

The Polyomaviridae constitute a family of small DNA viruses that infect a variety of hosts. BK polyomavirus (BKPyV) and JC polyomavirus (JCPyV), discovered in 1971 (1,2), are well-known examples of [...]

Published
2014
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23. A narrative review on current duodenoscope reprocessing techniques and novel developments

Author

MMB opleiding Arts microbioloog, MMB Medische Staf, Infection & Immunity, MS MDL 1, Cancer, Heuvelmans, Maarten, Wunderink, Herman F, van der Mei, Henny C, Monkelbaan, Jan F, MMB opleiding Arts microbioloog, MMB Medische Staf, Infection & Immunity, MS MDL 1, Cancer, Heuvelmans, Maarten, Wunderink, Herman F, van der Mei, Henny C, and Monkelbaan, Jan F

Published
2021

25. Autoantibodies against granulocyte macrophage colony-stimulating factor and Nocardia infection in solid organ transplant recipients.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert M, Wunderink, Herman F, Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, Candon, Sophie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert M, Wunderink, Herman F, Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, and Candon, Sophie

Abstract

Dear Editors, Nocardiosis is a rare but potentially severe bacterial opportunistic infection that may occur after solid organ transplantation (SOT), typically among thoracic transplant recipients and/or in recipients with a high degree of immunosuppression due to anti-rejection therapy [1]. However, nocardiosis may also occur late after transplantation among minimally immunosuppressed patients, suggesting that additional risk factors exist [1]. Recently, autoantibodies against granulocyte macrophage colony-stimulating factor (GM-CSF) have been identified among five previously healthy patients with disseminated nocardiosis [2]. These autoantibodies likely promote nocardiosis by reducing neutrophil and macrophage activation, phagocytosis, and bactericidal activity [2]. We hypothesized that anti-GM-CSF autoantibodies might be involved in post-SOT nocardiosis, especially in patients who apparently have a relatively low degree of immunosuppression. [...]

Published
2020

26. Autoantibodies against granulocyte macrophage colony-stimulating factor and Nocardia infection in solid organ transplant recipients

Author

Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert A.M., Wunderink, Herman H.F., Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, Candon, Sophie, Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert A.M., Wunderink, Herman H.F., Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, and Candon, Sophie

Abstract

SCOPUS: le.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

27. Autoantibodies against granulocyte macrophage colony‐stimulating factor and Nocardia infection in solid organ transplant recipients

Author

Lebeaux, David, primary, Coussement, Julien, additional, Chauvet, Cécile, additional, Matignon, Marie, additional, Scemla, Anne, additional, Bouvier, Nicolas, additional, Dantal, Jacques, additional, Vollaard, Albert M., additional, Wunderink, Herman F., additional, Van Wijngaerden, Eric, additional, Naesens, Maarten, additional, Kamar, Nassim, additional, De Greef, Julien, additional, Guillemain, Romain, additional, Borie, Raphael, additional, and Candon, Sophie, additional

Published
2020
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28. Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

Author

Siemens, Nikolai, primary, Oehmcke-Hecht, Sonja, additional, Hoßmann, Jörn, additional, Skorka, Sebastian B., additional, Nijhuis, Roel H.T., additional, Ruppen, Corinne, additional, Skrede, Steinar, additional, Rohde, Manfred, additional, Schultz, Daniel, additional, Lalk, Michael, additional, Itzek, Andreas, additional, Pieper, Dietmar H., additional, van den Bout, Christiaan J., additional, Claas, Eric C.J., additional, Kuijper, Ed J., additional, Mauritz, Robert, additional, Sendi, Parham, additional, Wunderink, Herman F., additional, and Norrby-Teglund, Anna, additional

Published
2019
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30. Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study

Author

Lebeaux, David, Freund, Romain, Delden, Christian, Guillot, Hélène, Marbus, Sierk D., Matignon, Marie, Van Wijngaerden, Eric, Douvry, Benoit, De Greef, Julien, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Jacobs, Frédérique, Lortholary, Olivier, Coussement, Julien, Anstey, James R., Antoine, Martine, Ausselet, Nathalie, Belhaj, Asmae, Boelens, Jerina, Beenhouwer, Hans, Denis, Catherine, Ho, Erwin, Ieven, Margareta, Jonckheere, Stijn, Knoop, Christiane, Moine, Alain, Rodriguez-Villalobos, Hector, Racapé, Judith, Roisin, Sandrine, Vandercam, Bernard, Vander Zwalmen, Marie-Laure, Vanfraechem, Gaëlle, Van Laecke, Steven, Verhaegen, Jan, Barrou, Benoit, Battistella, Pascal, Bergeron, Emmanuelle, Bouvier, Nicolas, Caillard, Sophie, Caumes, Eric, Chaussade, Hélène, Chauvet, Cécile, Crochette, Romain, Epailly, Eric, Essig, Marie, Gallien, Sébastien, Guillemain, Romain, Herel, Canan, Hoen, Bruno, Kamar, Nassim, Gall, Thierry, Levi, Charlene, Lionet, Arnaud, Longuet, Hélène, Melica, Giovanna, Miel, Anaick, Morel, Hélène, Ammar, Salima Ould, Pattier, Sabine, Peraldi, Marie-Noelle, Sayegh, Johnny, Scemla, Anne, Senechal, Agathe, Tourret, Jérome, Boggian, Katia, Egli, Adrian, Garzoni, Christian, Hoffman, Matthias, Hirsch, Hans H., Khanna, Nina, Manuel, Oriol, Meylan, Pascal, Mueller, Nicolas J., Posfay-Barbe, Klara M., Vu, Diem-Lan, Weisser, Maja, Vollaard, Albert M., Wunderink, Herman F., Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Lyon (ENVL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL), UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (MGD) Service de chirurgie cardio-vasculaire et thoracique, UCL - (MGD) Service de médecine interne générale, UCL - (SLuc) Service de médecine interne générale, and UCL - (SLuc) Service de microbiologie

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, [SDV]Life Sciences [q-bio], 030106 microbiology, Antibiotics, Improved survival, 610 Medicine & health, Nocardia, 03 medical and health sciences, Internal medicine, medicine, In patient, opportunistic infections, ddc:617, business.industry, Nocardiosis, organ transplantation, Odds ratio, medicine.disease, mortality, Confidence interval, 3. Good health, Surgery, Infectious Diseases, Conditional logistic regression, prognosis, Solid organ transplantation, business
Abstract

Background Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Factors associated with one-year all-cause mortality were identified using multivariable conditional logistic regression. Results One-year mortality was 10-fold higher in patients with nocardiosis (16.2%, 19/117) than in control transplant recipients (1.3%, 3/233, p

Published
2017

31. Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.

Author

Siemens, Nikolai, Oehmcke-Hecht, Sonja, Hoßmann, Jörn, Skorka, Sebastian B., Nijhuis, Roel H.T., Ruppen, Corinne, Skrede, Steinar, Rohde, Manfred, Schultz, Daniel, Lalk, Michael, Itzek, Andreas, Pieper, Dietmar H., van den Bout, Christiaan J., Claas, Eric C.J., Kuijper, Ed J., Mauritz, Robert, Sendi, Parham, Wunderink, Herman F., and Norrby-Teglund, Anna

Published
2020
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34. Foodborne trematodiasis and Opisthorchis felineus acquired in Italy

Author

Wunderink, Herman F., Rozemijer, Wouter, Wever, Peter C., Verweij, Jaco J., and van Lieshout, Lisette

Subjects
Fluke infections -- Case studies -- Diagnosis -- Care and treatment, Health
Abstract

To the Editor: Opisthorchiasis comprises diverse clinical manifestations caused by infections with Opisthorchis felineus or O. viverrini liver flukes, which are transmitted by eating infected raw or undercooked fish and [...]

Published
2014

35. Tenosynovitis caused by <italic>Mycobacterium malmoense</italic> in two kidney transplant recipients and review of the literature.

Author

van Grootveld, Rebecca, Wunderink, Herman F., Scherer, Hans U., Peters, Elke E. M., Gaasbeek, André, and Arend, Sandra M.

Subjects
*TENOSYNOVITIS, *MYCOBACTERIUM, *KIDNEY transplant patients, *IMMUNOSUPPRESSION, *DEBRIDEMENT, *DISEASE risk factors
Abstract

Abstract: We report two unrelated cases of tenosynovitis caused by Mycobacterium malmoense in kidney transplant recipients. Both patients received immunosuppression and were referred to our tertiary hospital because of persisting complaints lasting >6 months not responding to corticosteroids or surgery. The mycobacterial cultures were positive for the slow‐growing M. malmoense after several weeks of incubation. The patient in Case 1 was treated with a combination of surgical debridement and antibiotics, whereas the patient in Case 2 was only treated surgically. Both cases illustrate the doctor's delay in diagnosing mycobacterial infections, and remind us that nontuberculous mycobacterial infections should be part of the differential diagnosis of tenosynovitis, especially in immunocompromised patients. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Pelvic Actinomycosis-Like Disease Due to Propionibacterium propionicumafter Hysteroscopic Removal of an Intrauterine Device

Author

Wunderink, Herman F., Lashley, Eileen E. L. O., van Poelgeest, Marie¨tte I. E., Gaarenstroom, Katja N., Claas, Eric C. J., and Kuijper, Ed J.

Abstract

ABSTRACTA female patient presented with episodes of fever and pain in the lower right abdomen after hysteroscopic removal of an intrauterine device 2 months earlier. Pelvic actinomycosis originating from a tubo-ovarian abscess was diagnosed with Propionibacterium propionicum, formerly known as Arachnia propionica, as causative agent.

Published
2011
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40. Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

Author

Siemens, Nikolai, Oehmcke-Hecht, Sonja, Hoßmann, Jörn, Skorka, Sebastian B., Nijhuis, Roel H.T., Ruppen, Corinne, Skrede, Steinar, Rohde, Manfred, Schultz, Daniel, Lalk, Michael, Itzek, Andreas, Pieper, Dietmar H., Van Den Bout, Christiaan J., Claas, Eric C.J., Kuijper, Ed J., Mauritz, Robert, Sendi, Parham, Wunderink, Herman F., and Norrby-Teglund, Anna

Subjects
570 Life sciences, biology, 610 Medicine & health, 3. Good health

41. Pelvic actinomycosis-like disease due to Propionibacterium propionicum after hysteroscopic removal of an intrauterine device.

Author

Wunderink HF, Lashley EE, van Poelgeest MI, Gaarenstroom KN, Claas EC, and Kuijper EJ

Subjects
Actinomycosis microbiology, Adult, DNA, Bacterial chemistry, DNA, Bacterial genetics, Female, Humans, Molecular Sequence Data, Pelvis diagnostic imaging, Postoperative Complications microbiology, Propionibacterium classification, Radiography, Abdominal, Sequence Analysis, DNA, Tomography, X-Ray Computed, Actinomycosis diagnosis, Actinomycosis pathology, Hysteroscopy adverse effects, Intrauterine Devices microbiology, Postoperative Complications diagnosis, Postoperative Complications pathology, Propionibacterium isolation & purification
Abstract

A female patient presented with episodes of fever and pain in the lower right abdomen after hysteroscopic removal of an intrauterine device 2 months earlier. Pelvic actinomycosis originating from a tubo-ovarian abscess was diagnosed with Propionibacterium propionicum, formerly known as Arachnia propionica, as causative agent.

Published
2011
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