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Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave:a multicentre cross-sectional study with prospective follow-up
- Source :
- Recanatini , C , GeurtsvanKessel , C , Pas , S , Broens , E , Maas , M , van Mansfeld , R , Mutsaers-van Oudheusden , A J G , van Rijen , M , Schippers , E , Stegeman , A , Tami , A , Veldkamp , K E , Visser , H , Voss , A , Wegdam-Blans , M , Wertheim , H F L , Wever , P , Koopmans , M , Kluytmans , J A J W , Kluytmans-van den Bergh , M F Q , Bergmans , A , van den Bijllaardt , W , Broens , E , Buiting , A , Dohmen , W , Friedrich , A , GeurtsvanKessel , C , van der Gun , B , Heederik , D , de Jong , M , Kluytmans , J , Kluytmans-van den Bergh , M , Koopmans , M , Maas , M , van Mansfeld , R , Meijer , A , Murk , J L , Nabuurs , M , Niesters , B , ten Oever , J , Mutsaers-van Oudheusden , A , Pas , S , Recanatini , C , van Rijen , M , Schippers , E , Schweitzer , V , Stegeman , A , Streefkerk , R , Tami , A , Veldkamp , K E , Veloo , A , Visser , H , Voss , A , de Vries , J , Wegdam-Blans , M , Wertheim , H F L , Wever , P , Wold , K & Wunderink , H 2023 , ' Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave : a multicentre cross-sectional study with prospective follow-up ' , Antimicrobial Resistance and Infection Control , vol. 12 , no. 1 , 137 .
- Publication Year :
- 2023
-
Abstract
- Background: We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. Methods: HCWs from 13 Dutch hospitals were screened for antibodies against the spike protein of SARS-CoV-2 in June-July 2020 and after three months. Participants completed a retrospective questionnaire on determinants for occupational and community exposure to SARS-CoV-2 and symptoms suggestive of COVID-19 experienced since January 2020. The seroprevalence was calculated per baseline characteristic and symptom at baseline and after follow-up. Adjusted odds ratios (aOR) for seropositivity were determined using logistic regression. Results: Among 2328 HCWs, 323 (13.9%) were seropositive at enrolment, 49 of whom (15%) reported no previous symptoms suggestive of COVID-19. During follow-up, only 1% of the tested participants seroconverted. Seroprevalence was higher in younger HCWs compared to the mid-age category (aOR 1.53, 95% CI 1.07–2.18). Nurses (aOR 2.21, 95% CI 1.34–3.64) and administrative staff (aOR 1.87, 95% CI 1.02–3.43) had a higher seroprevalence than physicians. The highest seroprevalence was observed in HCWs in the emergency department (ED) (aOR 1.79, 95% CI 1.10–2.91), the lowest in HCWs in the intensive, high, or medium care units (aOR 0.47, 95% CI 0.31–0.71). Chronic respiratory disease, smoking, and having a dog were independently associated with a lower seroprevalence, while HCWs with diabetes mellitus had a higher seroprevalence. In a multivariable model containing all self-reported symptoms since January 2020, altered smell and taste, fever, general malaise/fatigue, and muscle aches were positively associated with developing antibodies, while sore throat and chills were negatively associated. 'Conclusions: The SARS-CoV-2 serop
Details
- Database :
- OAIster
- Journal :
- Recanatini , C , GeurtsvanKessel , C , Pas , S , Broens , E , Maas , M , van Mansfeld , R , Mutsaers-van Oudheusden , A J G , van Rijen , M , Schippers , E , Stegeman , A , Tami , A , Veldkamp , K E , Visser , H , Voss , A , Wegdam-Blans , M , Wertheim , H F L , Wever , P , Koopmans , M , Kluytmans , J A J W , Kluytmans-van den Bergh , M F Q , Bergmans , A , van den Bijllaardt , W , Broens , E , Buiting , A , Dohmen , W , Friedrich , A , GeurtsvanKessel , C , van der Gun , B , Heederik , D , de Jong , M , Kluytmans , J , Kluytmans-van den Bergh , M , Koopmans , M , Maas , M , van Mansfeld , R , Meijer , A , Murk , J L , Nabuurs , M , Niesters , B , ten Oever , J , Mutsaers-van Oudheusden , A , Pas , S , Recanatini , C , van Rijen , M , Schippers , E , Schweitzer , V , Stegeman , A , Streefkerk , R , Tami , A , Veldkamp , K E , Veloo , A , Visser , H , Voss , A , de Vries , J , Wegdam-Blans , M , Wertheim , H F L , Wever , P , Wold , K & Wunderink , H 2023 , ' Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave : a multicentre cross-sectional study with prospective follow-up ' , Antimicrobial Resistance and Infection Control , vol. 12 , no. 1 , 137 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1415729897
- Document Type :
- Electronic Resource