Author: "Wuhan University [China]" - Searchworks@Jio Institute Digital Library Search Results

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1,057 results on '"Wuhan University [China]"'

1. Convener and main organiser

Author: The experience of occupation, 1931-1949 (13-16 April 2008: Wuhan University, China), Lagrou, Pieter, The experience of occupation, 1931-1949 (13-16 April 2008: Wuhan University, China), and Lagrou, Pieter
Abstract: Conference organised by the International Committee for the History of the Second World War in cooperation with the Chinese National Committee for the History of the Second World War., info:eu-repo/semantics/nonPublished
Published: 2008

2. Multiscale analysis of a current sheet embedded in a fast earthward flow during a substorm event detected by MMS

Author: Rumi Nakamura, Alessandro Retinò, Stephen A. Fuselier, Alexandra Alexandrova, Julia E. Stawarz, Christian Jacquey, Olivier Le Contel, Daniel J. Gershman, Thomas Chust, Sergio Toledo, Matthew R. Argall, Katherine Goodrich, David Fischer, J. Mukherjee, Narges Ahmadi, L. Mirioni, Shiyong Huang, Filomena Catapano, Soboh Alqeeq, Daniel B. Graham, Laboratoire de Physique des Plasmas (LPP), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut für Weltraumforschung [Graz] (IWF), Osterreichische Akademie der Wissenschaften (ÖAW), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Department of Electromagnetism and Electronics [Murcia], Universidad de Murcia, Imperial College London, Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley], University of California-University of California, NASA Goddard Space Flight Center (GSFC), Southwest Research Institute [San Antonio] (SwRI), Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], Swedish Institute of Space Physics [Uppsala] (IRF), University of New Hampshire (UNH), Department of Space Physics [Wuhan], School of Electronic Information [Wuhan], and Wuhan University [China]-Wuhan University [China]
Subjects: Current sheet, Flow (mathematics), [PHYS.ASTR.EP]Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Event (relativity), Substorm, Geophysics, Geology
Abstract: In July 2017, the MMS constellation was evolving in the magnetotail with an apogee of 25 Earth radii and an average inter-satellite distance of 10 km (i.e. at electron scales). On 23 rd of July around 16:19 UT, MMS was located at the edge of the current sheet which was in a quasi-static state. Then, MMSsuddenly entered in the central plasma sheet and detected the local onset of a small substorm as indicated by the AE index (~400 nT). Fast earthward plasma flows were measured for about 1 hour starting with a period of quasi-steady flow and followed by a saw-tooth like series of plasma jets (“bursty bulk flows”). In the present study, we focus on a short sequence related to an ion scale current sheet crossing embedded in a fast earthward flow. We analyse in detail two other kinetic structures in the vicinity of this current sheet: an ion-scale flux rope and an electron vortex magnetic hole and discuss the Ohm’s law and conversion energy processes.
Published: 2021

3. Statistical study of the substorm onset: its dependence on solar wind parameters and solar illumination

Author: H. Wang, H. Lühr, S. Y. Ma, P. Ritter, EGU, Publication, GeoForschungsZentrum - Helmholtz-Zentrum Potsdam (GFZ), Department of Space Physics [Wuhan], School of Electronic Information [Wuhan], and Wuhan University [China]-Wuhan University [China]
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Magnetosphere, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, 550 - Earth sciences, 01 natural sciences, Latitude, Physics::Geophysics, 0103 physical sciences, Substorm, Earth and Planetary Sciences (miscellaneous), Astrophysics::Solar and Stellar Astrophysics, Surge, lcsh:Science, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, [SDU.OCEAN] Sciences of the Universe [physics]/Ocean, Atmosphere, lcsh:QC801-809, Northern Hemisphere, Geology, Astronomy and Astrophysics, Geophysics, lcsh:QC1-999, Solar wind, lcsh:Geophysics. Cosmic physics, 13. Climate action, Space and Planetary Science, Local time, Physics::Space Physics, [SDU.STU] Sciences of the Universe [physics]/Earth Sciences, lcsh:Q, Astrophysics::Earth and Planetary Astrophysics, Ionosphere, lcsh:Physics
Abstract: Based on 1829 well-defined substorm onsets in the Northern Hemisphere, observed during a 2-year period by the FUV Imager on board the IMAGE spacecraft, a statistical study is performed. From the combination of solar wind parameter observations by ACE and magnetic field observations by the low altitude satellite CHAMP, the location of auroral breakups in response to solar illumination and solar coupling parameters are studied. Furthermore, the correspondence of the onset location with prominent large-scale field-aligned currents and electrojets are investigated. Solar illumination and the related ionospheric conductivity have significant effects on the most probable substorm onset latitude and local time. In sunlight, substorm onsets tend to occur 1h earlier in local time and 1.5° more poleward than in darkness. The solar wind input, represented by the merging electric field, integrated over 1h prior to the substorm, correlates well with the latitude of the breakup. Most poleward latitudes of the onsets are found to range around 73° magnetic latitude during very quiet times. Field-aligned and Hall currents observed concurrently with the onset are consistent with the signature of a westward travelling surge evolving out of the Harang discontinuity. The observations suggest that the ionospheric conductivity has an influence on the location of the precipitating energetic electron which causes the auroral break-up signature. Keywords. Ionosphere (Auroral ionosphere) – Magnetospheric Physics (Current systems; Magnetosphereionosphere interactions)
Published: 2018

4. A virus-borne DNA damage signaling pathway controls the lysogeny-induction switch in a group of temperate pleolipoviruses

Author: Zhao Chen, Ying Liu, Yixuan Wang, Xincheng Du, Xiaoyuan Deng, Jialin Xiang, Yangyang Wang, Jiao Wang, Mart Krupovic, Shishen Du, Xiangdong Chen, Wuhan University [China], Virologie des archées - Archaeal Virology, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Natural Science Foundation of China [32270167], National Foundation for Fostering Talents of Basic Sciences [J1103513], and Research (Innovative) Fund of Laboratory Wuhan University (to X.C.).
Subjects: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Genetics
Abstract: Many prokaryotic viruses are temperate and their reactivation is tightly regulated. However, except for a few bacterial model systems, the regulatory circuits underlying the exit from lysogeny are poorly understood, especially in archaea. Here, we report a three-gene module which regulates the switch between lysogeny and replicative cycle in a haloarchaeal virus SNJ2 (family Pleolipoviridae). The SNJ2 orf4 encodes a winged helix-turn-helix DNA binding protein which maintains lysogeny through repressing the expression of the viral integrase gene intSNJ2. To switch to the induced state, two other SNJ2-encoded proteins, Orf7 and Orf8, are required. Orf8 is a homolog of cellular AAA+ ATPase Orc1/Cdc6, which is activated upon mitomycin C-induced DNA damage, possibly through posttranslational modification. Activated Orf8 initiates the expression of Orf7 which, in turn, antagonizes the function of Orf4, leading to the transcription of intSNJ2, thereby switching SNJ2 to the induced state. Comparative genomics analysis revealed that the SNJ2-like Orc1/Cdc6-centered three-gene module is common in haloarchaeal genomes, always present in the context of integrated proviruses. Collectively, our results uncover the first DNA damage signaling pathway encoded by a temperate archaeal virus and reveal an unexpected role of the widely distributed virus-encoded Orc1/Cdc6 homologs.
Published: 2023

5. Effect of chronic left ventricular unloading on myocardial remodeling: Multimodal assessment of two heterotopic heart transplantation techniques

Author: Yihua Liu, Celine Gu, Frederique Groubatch, Nguyen Tran, Arnauld Olivier, P. Maureira, Aude Falanga, Guillaume Gauchotte, Pierre-Yves Marie, Venessa Marie, Service de Chirurgie Cardio-vasculaire [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Department of Cardiothoracic Surgery, Zhongnan Hospital, Wuhan University [China]-Wuhan University [China], Service de Pathologie [CHRU Nancy], Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Cardiologie [CHRU Nancy], Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL)
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Transplantation, Heterotopic, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Diastole, Hemodynamics, Ventricular Dysfunction, Left, Atrophy, Fibrosis, Internal medicine, medicine, Animals, Interventricular septum, Heart transplantation, Transplantation, Ejection fraction, Ventricular Remodeling, business.industry, medicine.disease, Rats, Disease Models, Animal, medicine.anatomical_structure, Rats, Inbred Lew, Chronic Disease, Cardiology, Heart Transplantation, Surgery, Cardiology and Cardiovascular Medicine, business
Abstract: International audience; BACKGROUND:Cardiac recovery is possible by means of mechanical unloading yet remains rare. Excessive unloading-associated myocardial atrophy and fibrosis may adversely affect the process of reverse remodeling. In this study, we sought to evaluate the effect of different intensities of chronic left ventricular (LV) unloading on myocardial remodeling.METHODS:Twenty-five isogenic Lewis rats underwent complete LV unloading (CU, n = 15) induced by heterotopic heart transplantation or partial LV unloading (PU, n = 10) by heterotopic heart-lung transplantation. Information obtained from serial echocardiography, 2-deoxy-2[(18)F]fluoro-d-glucose ((18)F-FDG)-positron emission tomography, and an LV pressure-volume catheter were used to evaluate the morphology, glucose metabolism, and hemodynamic performance of the orthotopic hearts and heterotopic transplants over 4 weeks. Cell size, collagen content, tissue cytokines (interleukin [IL]-1α, IL-2, IL-6, IL-10, tumor necrosis factor-α, and vascular endothelial growth factor), and matrix metalloproteinase-2 and -9 were also determined. The recorded parameters included LV end-systolic dimension, LV end-diastolic dimension, posterior wall thickness, diastolic interventricular septum thickness, LV fractional shortening, and LV ejection fraction.RESULTS:We demonstrated an LV load-dependent relationship using echo-based structural (left posterior wall thickness, diastolic interventricular septum thickness, and left ventricular end-diastolic dimension) and functional (LV fractional shortening and LV ejection fraction) parameters, as well as an (18)F-FDG uptake (all p < 0.05). This load-dependent relationship was also evidenced in measurements from the pressure-volume conductance catheter (stroke volume, stroke work, cardiac output, dP/dTmax, and -dP/dTmin; all p < 0.05). Significant myocardial atrophy and fibrosis were observed in unloaded hearts, whereas concentrations of cytokines and matrix metalloproteinases were comparable in both unloading conditions.CONCLUSIONS:Partial and complete unloading affected the remodeling of non-failing hearts in a rodent model to different extents on myocardial atrophy, fibrosis, glucose metabolism, and mechanical work. Cardiac atrophy is the prominent change after mechanical unloading, which exaggerates the proportion of total collagen that is responsible for diastolic dysfunction.
Published: 2015

6. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)

Author: J. Donald Easton, Maria Aunes, Gregory W. Albers, Pierre Amarenco, Sara Bokelund-Singh, Hans Denison, Scott R. Evans, Peter Held, Marianne Jahreskog, Jenny Jonasson, Kazuo Minematsu, Carlos A. Molina, Yongjun Wang, K.S. Lawrence Wong, S. Claiborne Johnston, Sebastiá F. Ameriso, Geoffrey Donnan, Robin Lemmens, Ayrton Massaro, Ekaterina Titianova, Michael D. Hill, Pablo Lavados, David Skoloudik, Joachim Röther, Szegedi Norbert, Giancarlo Agnelli, Natan Bornstein, Norio Tanahashi, Angel Arauz Góngora, Edwin Pretell, Maria Cristina Z. San Jose, Anna Czlonkowska, Ovidiu Bajenaru, Ludmila Stakhovskaya, Miroslav Brozman, Jong-Sung Kim, Nils Wahlgren, Patrik Michel, Tsong Hai Lee, Nijasri Charnnarong Suwanwela, Kursad Kutluk, Sergii Moskovko, Scott Kasner, Daniel Laskowitz, Wayne Clark, Huy Thang Nguyen, Sebastian Ameriso, Sandra Lepera, Marina Romano, David Paulon, Pablo Ioli, Cristina Zurru, Guadalupe Bruera, Lorena Jure, Francisco Klein, Guillermo Povedano, Christopher Levi, Thanh Phan, Romesh Markus, Craig Anderson, Arman Sabet, Stephen Davis, Andrew Lee, Timothy Kleinig, Andrew Wong, Martin Krause, Jim Jannes, Tissa Wijeratne, Dimitri Hemelsoet, André Peeters, Philippe Tack, Peter Vanacker, Patrice Laloux, William Van Landegem, Geert Vanhooren, Philippe Desfontaines, Marc Van Orshoven, Fabio Oliveira, Mauricio Friedrich, Rosane Brondani, Rubens Gagliardi, Soraia Fabio, Marianna Dracoulakis, Rodrigo Bazan, Luiz Marrone, Octavio Pontes Neto, Gisele Silva, Pedro Kowacs, Paraskeva Stamenova, Marin Daskalov, Ivan Staikov, Dimo Baldaranov, Dimitar Maslarov, Hristo Lilovski, Plamen Petkov, Neli Petrova, Radoslav Mavrov, Veska Markova, Valeria Petrova, Tanya Beleva, Borislav Kralev, Nikolay Sotirov, Veska Lekova, Dimcho Hristov, Vera Ermenkova, Lyudmil Mateev, Rumeliya Mitkova, Liybomir Haralanov, Rosen Ikonomov, Margarita Mihailova, Ivan Georgiev, Ashfaq Shuaib, Vladimir Hachinski, Jean-Martin Boulanger, Sharan Mann, Ayman Hassan, Ariane Mackey, Bijoy Menon, Jeffrey Minuk, Muzaffar Siddiqui, Marsha Eustace, Lucia Vieira, Daniel Selchen, Michel Beaudry, Grant Stotts, Angel Castro, Kristo Gasic, Rodrigo Rivas, Pablo Sanchez, Andres Roldan, Ingrid Grossmann, Christian Figueroa, Jimei Li, Xiaolin Xu, Huisheng Chen, Xiaohong Li, Yi Yang, Chunsheng Zhang, Baojun Wang, Guanglai Li, Dong Wang, Hong Lin, Yamei Tang, Anding Xu, Yanjiang Wang, Wenke Hong, Zhi Song, Xu Zhang, Xiaoping Jin, Yun Xu, Fuling Yan, Weihong Zheng, Xiaoping Wang, Qiang Dong, Zhongxin Zhao, Baorong Zhang, Wangtao Zhong, Guoqiang Wen, Jun Xu, Guozhong Li, Xueshuang Dong, Xiangyang Tian, Zhaohui Zhang, En Xu, Kaixiang Liu, Jun Chen, Ondrej Skoda, Edvard Ehler, Daniel Vaclavik, Daniel Sanak, Sylva Klimosova, Eva Vitkova, Jan Fiksa, Robert Mikulik, Jiri Neumann, Richard Plny, Didier Leys, Igor Sibon, Jean-Louis Mas, Sonia Alamowitch, Fernando Pico, Hassan Hosseini, Marie-Hélène Mahagne, Emmanuel Touze, Wilfried Vadot, Stéphane Vannier, Norbert Nighoghossian, Yves Samson, Pierre Garnier, Emmanuel Ellie, Benoît Guillon, Serge Timsit, Maurice Giroud, Frédéric Philippeau, Aude Bagan-Triquenot, Valérie Wolff, Nicolas Raposo, Michel Obadia, Severine Debiais, Jérôme Grimaud, Stéphane Illouz, Didier Smadja, Cédric Urbanczyk, Jörg Berrouschot, Christian Weimar, Georg Gahn, Hassan Soda, Sven Klimpe, Darius Nabavi, Jörg Glahn, Martin Köhrmann, Lars Krause, Christoph Terborg, Peter Urban, Thorsten Steiner, Andreas Ferbert, Rainer Dziewas, Günter Seidel, Götz Thomalla, Richard Li, Wing Chi Fong, Raymond Cheung, Norbert Szegedi, Krisztián Pozsegovits, Attila Valikovics, Gyula Pánczél, Csilla Rózsa, László Németh, Péter Diószeghy, Csaba Óváry, Attila Csányi, Levente Kerényi, Valéria Nagy, Sámuel Komoly, Dániel Bereczki, Sándor Molnár, István Kondákor, David Tanne, Guy Raphaeli, Gregory Telman, Ronen Leker, Yair Lampl, Francesco Corea, Stefano Ricci, Donata Guidetti, Giovanni Malferrari, Simona Marcheselli, Giuseppe Micieli, Andrea Zini, Vincenzo Di Lazzaro, Carlo Gandolfo, Andrea Salmaggi, Rossana Tassi, Maurizia Rasura, Giovanni Orlandi, Giancarlo Comi, Michelangelo Mancuso, Marialuisa Delodovici, Paolo Bovi, Domenico Consoli, Kimiaki Utsugisawa, Tsuneo Fujita, Hideyuki Kurihara, Chikashi Maruki, Takeshi Hayashi, Tsuneaki Ogiichi, Morio Kumagai, Katsunobu Takenaka, Kazunori Toyoda, Kazuhiro Takamatsu, Ryo Ogami, Shigenari Kin, Takeshi Aoki, Katsumi Takizawa, Shigehiro Omori, Takehiko Umezawa, Yasuyuki Toba, Yutaka Nonoyama, Hidemitsu Nakagawa, Takashi Naka, Masanori Morimoto, Shuichi Matsumoto, Tsutomu Hitotsumatsu, Tatsuya Shingaki, Satoshi Okuda, Mamoru Ota, Nobuyuki Sakai, Takeshi Yamada, Jun Niwa, Hitoshi Fujita, Akihito Moriki, Kimihiro Yoshino, Yoshihisa Fukushima, Takahisa Mori, Atsushi Sato, Yoshikazu Kusano, Michiya Kubo, Masashi Yamazaki, Takao Ooasa, Takafumi Nishizaki, Naoki Kitagawa, Masahiro Yasaka, Yasuhiro Manabe, Akira Yoshioka, Masayuki Ishihara, Takato Kagawa, Toshikazu Ichihashi, Hideki Matsuoka, Yasuhiro Ito, Masahiro Yamasaki, Hitonori Takaba, Hisatoshi Saito, Masahiro Sato, Kazumasa Fukuda, Sumio Endo, Minoru Kidooka, Toshitaka Umemura, Yuriko Kikkawa, Shuta Toru, Kentaro Yamada, Hideki Sakai, Jun Asari, Masayuki Ezura, Hisashi Nitta, Keiko Nagano, Jun Ochiai, Keiichi Sakai, Yasutaka Kobayashi, Yasuhiro Yoshii, Hirotomo Miake, Tomohiro Takita, Hidekazu Taniguchi, Kazuhiko Kuroki, Takamitsu Mizota, Kenichi Yamamoto, Hiroshi Nakane, Takeshi Iwanaga, Kei Chiba, Tetsuyuki Yoshimoto, Tsuyoshi Torii, Takeo Kitagawa, Hiroshi Takashima, Naoki Shirasaki, Makoto Dehara, Naomichi Wada, Kensuke Hamada, Noriyuki Kato, Yoshinori Go, Ichiro Izumi, Hirotomo Ninomiya, Junichiro Kumai, Yoshikazu Nakajima, Yasuhiko Kaku, Yukihiro Isayama, Masahiro Kawanishi, Shinya Noda, Kazuhide Yamamoto, Takanori Hazama, Hiroshi Takahashi, Yohei Tanaka, Takashi Hata, Kiyoshi Kazekawa, Eisuke Furui, Hideki Hondo, Nobuyuki Sato, Katsusuke Kusunoki, Kazunori Nanri, Satoshi Abe, Noboru Sasaoka, Takayuki Kuroyanagi, Hisahiko Suzuki, Kouzou Fukuyama, Kimihiro Nakahara, Fernando Gongora, Carlos Cantú Brito, Jorge Villarreal Careaga, Rosalia Vazquez Alfaro, Geronimo Aguayo Leytte, Percy Berrospi, Carlos Chavez, Liliana Rodriguez, Nilton Custodio, Cesar Castañeda, Julio Perez, Maria Cristina San Jose, Alejandro Baroque, Epifania Collantes, Abdias Aquino, Alejandro Díaz, Artemio Roxas, Johnny Lokin, Joel Advincula, Emerito Calderon, Jose Navarro, John Hiyadan, Arturo Surdilla, Danuta Ryglewicz, Grzegorz Krychowiak, Waldemar Fryze, Piotr Sobolewski, Ryszard Nowak, Urszula Fiszer, Beata Papierowska, Justyna Zielińska-Turek, Anetta Lasek-Bal, Ewa Kołodziejska, Anna Kamińska, Bożena Adamkiewicz, Andrzej Tutaj, Dorota Szkopek, Krzysztof Musiatowicz, Zbigniew Bąk, Sławomir Brzozowski, Waldemar Brola, Antoni Ferens, Marek Zalisz, Konrad Rejdak, Monika Rudzińska, Cristina Panea, Mihaela Simu, Rodica Balasa, Iulian Cuciureanu, Bogdan Popescu, Monica Sabau, Corina Roman-Filip, Leonid Pimenov, Alla Gekht, Anna Milto, Ivan Shchukin, Vladimir Parfenov, Liudmila Stakhovskaya, Mikhail Arkhipov, Nadezhda Sokolova, Enver Bogdanov, Radiy Esin, Dina Khasanova, Konstantin Golikov, Elena Melnikova, Leonid Zaslavskiy, Igor Voznyuk, Alexander Nazarov, Leila Akhmadeeva, Aida Iakupova, Nikolay Shamalov, Galina Belskaya, Svetlana Chuprina, Olga Denisova, Ekaterina Drozdova, Yuliya Karakulova, Ilya Sholomov, Nikolay Spirin, Elena Vostrikova, Elena Mordvintseva, Vera Grigoryeva, Dmitry Zateyshchikov, Vladimir Gorbachev, Zhanna Chefranova, Mikhail Dudarev, Rostislav Nilk, Alexey Rozhdestvenskiy, Ladislav Gurcik, Miloslav Dvorak, Georgi Krastev, Egon Kurca, Juraj Vyletelka, Jong Sung Kim, Hee-Joon Bae, Yong-Won Kim, Joon-Tae Kim, Jae-Kwan Cha, Hyo Suk Nam, Dae-Il Chang, Yong-Seok Lee, Kyungmi Oh, Sung-Wook Yu, Sung-Il Sohn, Jun Lee, Han Jin Cho, Eung-Gyu Kim, Joung-Ho Rha, Seo Hyun Kim, Carlos Molina Cateriano, Joaquín Serena Leal, José Vivancos Mora, Manuel Rodríguez Yañez, Jaume Roquer González, Francisco Purroy García, Meritxell Gomis Cortina, Jaime Masjuan Vallejo, Juan Arenillas Lara, Tomás Segura Martín, José Antonio Egido Herrero, Jose Ignacio Tembl Ferrairó, Jaime Gállego Culleré, Francisco Moniche Álvarez, Anna Steinberg, Margarita Callander, Ann Charlotte Laska, Lena Bokemark, Thomas Mooe, Tor-Björn Käll, Lennart Welin, Lars Sjöblom, Joakim Hambraeus, Jörg Teichert, Hans Wannberg, Johan Sanner, Bo Ramströmer, Bo Ziedén, Stefan Olsson Hau, Claes Gustafsson, Timo Kahles, Philippe Lyrer, Marcel Arnold, Martin Liesch, Friedrich Medlin, Carlo Cereda, Georg Kägi, Andreas Luft, Emmanuel Carrera, Tsong-Hai Lee, Helen L. Po, Chang-Ming Chern, Li-Ming Lien, Lung Chan, Chung-Hsiang Liu, Shey-Lin Wu, Jiann-Der Lee, Chih-Hung Chen, Huey-Juan Lin, Ruey-Tay Lin, Wei-Hsi Chen, Yu Sun, Tasanee Tantirittisak, Sombat Muengtaweepongsa, Yongchai Nilanont, Somsak Tiamkao, Chesda Udommongkol, Kanokwan Watcharasaksilp, Witoon Jantararotai, Hadiye Sirin, Birsen Ince, Talip Asil, Murat Arsava, Tulay Kurt Incesu, Hulya Tireli, Hayriye Kucukoglu, Fikri Ak, Ali Unal, Serefnur Ozturk, Nevzat Uzuner, Galyna Chmyr, Volodymyr Lebedynets, Vadym Nikonov, Lyudmyla Shulga, Volodymyr Smolanka, Marta Khavunka, Valentyna Yavorska, Nataliya Tomakh, Olexandr Kozyolkin, Galyna Litovaltseva, Maarten Lansberg, Richard Bernstein, David Brown, Jonathan Dissin, Carmelo Graffagnino, Jonathan Harris, William Hicks, Irene Katzan, Jeffrey Kramer, Joshua Willey, Scott Silliman, Sidney Starkman, David Thaler, Margaret Tremwel, Mauricio Concha, Kumar Rajamani, Bhuvaneswari Dandapani, Brian Silver, Nathan Deal, Ira Chang, Ameer Hassan, Steven Rudolph, Kenneth Fischer, Howard Kirshner, William Logan, Sidney Mallenbaum, Hebah Hefzy, Julius Latorre, Steven Levine, Anthony Ciabarra, Rima Dafer, Benjamin Anyanwu, Laurel Cherian, Spozhmy Panezai, Anna Khanna, Jodi Dodds, Michel Torbey, James Gebel, Henry Woo, David Chiu, Xiao Androulakis, William Burgin, Maria Pineda, Engin Yilmaz, Irfan Altafullah, Christine Boutwell, Salvador Cruz-Flores, Biggya Sapkota, Pierre Fayad, Michael Jacoby, Shahid Rafiq, Efrain Salgado, Eugene Lafranchise, Warren Felton, Ramesh Madhavan, Osama Zaidat, Connie Pieper, Ralph Riviello, Aaron Burnett, Michelle Fischer, Nina Gentile, Christopher Calder, Dennis Dietrich, Jonathan Cross, Larry Blankenship, Liliana Montoya, Wendell Grogan, Mark Young, Farrukh Khan, Duane Campbell, Nizar Daboul, Andrey Espinoza, Paul Cullis, Gilberto Concepcion, John Wulff, Haider Afzal, Naseem Jaffrani, William Reiter, Tamjeed Arshad, Timothy Lukovits, James Welker, Fen Lei Chang, Aamir Badruddin, Viken Babikian, Ravi Menon, James Sander, Mellanie Springer, Ashish Nanda, Luis Mas, Raj Rajan, Bruce Silverman, David Huang, David Carpenter, Joni Clark, Marilou Ching, Sunitha Santhakumar, Jeffrey Gould, Vibhav Bansal, Gabriel Vidal, Timothy Mikesell, John Brick, William French, Qaisar Shah, Christine Holmstedt, Nadir Ishag-Osman, John Kostis, Abbas Shehadeh, Pramodkumak Sethi, Asher Imam, Carl Mccomas, Duc Tran, Mehari Gebreyohanns, Brian Wiseman, Maheen Malik, Aron Schwarcz, Dorothea Altschul, John Castaldo, Amer Alshekhlee, Stephen Gancher, Nagesh Krish, Mai Nguyen-Huynh, Margaret Tremwell, Jitendra Sharma, Lance Lee, William Neil, Fazeel Siddiqui, Ali Malek, Charles Romero, Thang Nguyen Huy, Hoa Hoang, Thang Nguyen, Anh Nguyen, Hung Nguyen, Laboratoire de Recherche Vasculaire Translationnelle ( LVTS ), Université Paris 13 ( UP13 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), AstraZeneca, National Cerebral and Cardiovascular Center ( NCCC - OSAKA ), Osaka University [Osaka], Department of Neurology ( Dep Neuro - BEIJING ), Tiantan Hospital, University of Melbourne, Faculty of Mathematics and Statistics, Ton Duc Thang University, Ho Chi Minh City, Heidelberg University, Centre hospitalier de Namur, IBM Thomas J. Watson Research Center, IBM, Bulgarian Academy of Sciences, Department of Clinical Neurological Sciences [London, Canada], University of Western Ontario ( UWO ), Servicio de Neurologia ( SANTIAGO - Neurologie ), Universidad de Santiago de Chile [Santiago] ( USACH ) -Universidad del Desarrollo, Institut de Chimie de Clermont-Ferrand - Clermont Auvergne ( ICCF ), Sigma CLERMONT ( Sigma CLERMONT ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Universidad de Talca, Shanghai Second Polytechnic University, Northwest Normal University [Lanzhou], Zhongda Hospital, Southeast University [Jiangsu], Cryogenics Laboratory ( CRYOGENICS LABORATORY ), Huazhong University of Science and Technology [Wuhan] ( HUST ) -Wuhan University [China], Centre for Synthetic and Systems Biology, University of Edinburgh-School of Biological Sciences, Duke university [Durham], Fiber Glass, Glass Business and Discovery Center, PPG Industries, National University of Defense Technology [Changsha], School of Oceanography [Seattle], University of Washington [Seattle], Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guilin University of Technologie, Laboratoire de Génie Electrique et Ferroélectricité ( LGEF ), Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Université de Lyon-Institut National des Sciences Appliquées ( INSA ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Université de Bordeaux ( UB ), Service de Pédiatrie, Centre Hospitalier Universitaire de Nice ( CHU Nice ) -Hôpital l'Archet, Université Pierre et Marie Curie - Paris 6 ( UPMC ), Centre Hospitalier de Versailles ( CHV ), Service de neurologie, Hôpital Sainte-Anne, Functional Exploration of Nervous, CHU Grenoble, Service de Neurologie [Rennes], Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Français de Mécanique Avancée ( IFMA ), Neurologie - Côte Basque ( NEUROLOGIE ), Hopital, Laboratoire d'Intégration des Systèmes et des Technologies ( LIST ), Université Paris-Saclay-Direction de Recherche Technologique (CEA) ( DRT (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) ( GGB ), Institut Brestois Santé Agro Matière ( IBSAM ), Université de Brest ( UBO ) -Université de Brest ( UBO ) -EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), CIC Brest, Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Hôpital de la Cavale Blanche, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), CHU Strasbourg, Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. ( ISCT ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès ( UT2J ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès ( UT2J ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of Neurology, Asklepios Klinik Altona, Department of Neurology and Stroke Center, Universität Duisburg-Essen [Essen], Department of Neurology, University of Mainz, Vivantes Klinikum Neukölln, University of Erlangen, University Hospital Münster, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] ( UKE ), PROTOMED, Neurology Department, Ichilov Medical Center, Internal and Cardiovascular Medicine - Stroke Unit ( PERUGIA - ICM-SU ), Università degli Studi di Perugia ( UNIPG ), University Hospital San Raffaele Milan, Scientific Institute and University Ospedale San Raffaele, Dipartimento di Scienze Fisiche, della Terra e dell'Ambiente., Università degli Studi di Siena ( UNISI ), Department of Education, Yamagata University, Nippon Medical School, Catalan Institute of Ornithology (ICO), Museu de Ciències Naturals (Zoologia), Wroclaw University of Science and Technology, Department of neurology, Jagiellonian University [Krakow] ( UJ ), LInguistique et DIdactique des Langues Étrangères et Maternelles ( LIDILEM ), Université Stendhal - Grenoble 3-Université Grenoble Alpes ( UGA ), Metacohorts Consortium, GenXpro GmBH, Lausanne University Hospital, Lausanne university hospital, Northeastern University [Boston], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Cerebral and Cardiovascular Center (NCCC - OSAKA), Department of Neurology (Dep Neuro - BEIJING), Bulgarian Academy of Sciences (BAS), University of Western Ontario (UWO), Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Shanghai Polytechnic University (SSPU), Cryogenics Laboratory (CRYOGENICS LABORATORY), Huazhong University of Science and Technology [Wuhan] (HUST)-Wuhan University [China], Centre for Synthetic and Systems Biology (Ssynthsys), University of Edinburgh, Duke University [Durham], National University of Defense Technology [China], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Bordeaux (UB), Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Université Pierre et Marie Curie - Paris 6 (UPMC), Centre Hospitalier de Versailles André Mignot (CHV), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut Français de Mécanique Avancée (IFMA), Neurologie - Côte Basque (NEUROLOGIE), Centre hospitalier universitaire de Nantes (CHU Nantes), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Internal and Cardiovascular Medicine - Stroke Unit (PERUGIA - ICM-SU), Università degli Studi di Perugia (UNIPG), Università degli Studi di Siena = University of Siena (UNISI), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurologie - Côte Basque, Centre Hospitalier de la Côte Basque (CHCB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Università degli Studi di Perugia = University of Perugia (UNIPG), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-SIGMA Clermont (SIGMA Clermont), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Jagiellonian University [Krakow] (UJ), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), Weimar, Christian (Beitragende*r), and Calvez, Ghislaine
Subjects: Male, Risk, Ticagrelor, Adenosine, [SDV]Life Sciences [q-bio], Population, Medizin, Hemorrhage, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Platelet aggregation inhibitors, Physiology (medical), [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, medicine, Humans, Myocardial infarction, education, Stroke, ComputingMilieux_MISCELLANEOUS, Aged, Aspirin, Ischemic attack, Transient, Female, Ischemic Attack, Transient, Purinergic P2Y Receptor Antagonists, Treatment Outcome, Cardiology and Cardiovascular Medicine, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ SDV ] Life Sciences [q-bio], Ischemic Attack, business.industry, medicine.disease, Clopidogrel, [SDV] Life Sciences [q-bio], Anesthesia, Platelet aggregation inhibitor, business, 030217 neurology & neurosurgery, TIMI, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug
Abstract: Background: Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes) was the first trial with ticagrelor in patients with acute ischemic stroke or transient ischemic attack in which the efficacy and safety of ticagrelor were compared with those of aspirin. The main safety objective was assessment of PLATO (Platelet Inhibition and Patient Outcomes)–defined major bleeds on treatment, with special focus on intracranial hemorrhage (ICrH). Methods: An independent adjudication committee blinded to study treatment classified bleeds according to the PLATO, TIMI (Thrombolysis in Myocardial Infarction), and GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) definitions. The definitions of ICrH and major bleeding excluded cerebral microbleeds and asymptomatic hemorrhagic transformations of cerebral infarctions so that the definitions better discriminated important events in the acute stroke population. Results: A total of 13 130 of 13 199 randomized patients received at least 1 dose of study drug and were included in the safety analysis set. PLATO major bleeds occurred in 31 patients (0.5%) on ticagrelor and 38 patients (0.6%) on aspirin (hazard ratio, 0.83; 95% confidence interval, 0.52–1.34). The most common locations of major bleeds were intracranial and gastrointestinal. ICrH was reported in 12 patients (0.2%) on ticagrelor and 18 patients (0.3%) on aspirin. Thirteen of all 30 ICrHs (4 on ticagrelor and 9 on aspirin) were hemorrhagic strokes, and 4 (2 in each group) were symptomatic hemorrhagic transformations of brain infarctions. The ICrHs were spontaneous in 6 and 13, traumatic in 3 and 3, and procedural in 3 and 2 patients on ticagrelor and aspirin, respectively. In total, 9 fatal bleeds occurred on ticagrelor and 4 on aspirin. The composite of ICrH or fatal bleeding included 15 patients on ticagrelor and 18 on aspirin. Independently of bleeding classification, PLATO, TIMI, or GUSTO, the relative difference between treatments for major/severe bleeds was similar. Nonmajor bleeds were more common on ticagrelor. Conclusions: Antiplatelet therapy with ticagrelor in patients with acute ischemic stroke or transient ischemic attack showed a bleeding profile similar to that of aspirin for major bleeds. There were few ICrHs. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01994720.
Published: 2017

7. Toward a better understanding of peroxymonosulfate and peroxydisulfate activation using a nano zero-valent iron catalyst supported on graphitized carbon: Mechanisms and application to the degradation of estrogenic compounds in different water matrix

Author: Cai, Minjuan, Cheng, Peng, Li, Jinjun, Wu, Feng, Sarakha, Mohamed, Mailhot, Gilles, Brigante, Marcello, Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), and Wuhan University [China]
Subjects: [SDE.IE]Environmental Sciences/Environmental Engineering, Advanced oxidation processes, [CHIM]Chemical Sciences, Ferryl ions, [CHIM.CATA]Chemical Sciences/Catalysis, Radical formation, Fenton-like activation, Endocrine Disrupting Compounds
Abstract: In this study, we employed nano zero-valent iron catalysts supported on graphitized carbon (GC-nZVI) catalyst to efficiently degrade BPA under circumneutral pH conditions in both dark and UVA radiation. The GC-nZVI catalyst was characterized using specific techniques (XPS, FTIR, BET, etc.), and was used to activate both PS and PMS in solution. Although no significant BPA degradation constant (k BPA) was determined using PS/PMS or GC-nZVI alone, a significant synergistic effect was observed in the system. Under dark conditions, k BPA increased from 0.01 min-1 to 0.17 when PS was used, both in the dark and under UVA. Notably, when PMS was present in the system, the improvement was even higher with k BPA reaching 0.18 and 0.26 min-1 under dark and UVA conditions, respectively. To further support the synergistic effect, it was found that 80 % of mineralization was achieved within 2 hours of UVA exposure. Chemical quenching experiments were conducted using selective probes and kinetic modelling showed that the activation of PS/PMS produced sulfate radicals (SO 4 •−), hydroxyl radicals (• OH) and ferryl ions (Fe IV O 2+) in both systems. Additionally, GC-nZVI/PMS system demonstrated good stability in recycling experiments, with up to 70 % of BPA still being degraded after 3 cycled in 1 hour under UVA. In conclusion, the degradation efficiencies of GC-nZVI/PMS and GC-nZVI/PS systems under dark and UVA radiation were assessed for three different EDCs (BPA, E2, and EE2) in both tap and sewage treatment plant waters. This study has demonstrated that the highly efficient GC-nZVI /PS/UVA or GC-nZVI/PMS/UVA system has significant potential for application in different water matrix, and our findings provide insights into the design of heterogeneous Fenton-like and photo-Fenton-like catalysts.
Published: 2023

8. Physicochemical degradation of phycocyanin and means to improve its stability: A short review

Author: Aïda Adjali, Igor Clarot, Zilin Chen, Eric Marchioni, Ariane Boudier, Cibles thérapeutiques, formulation et expertise pré-clinique du médicament (CITHEFOR), Université de Lorraine (UL), Wuhan University [China], Chinese Academy of Sciences [Beijing] (CAS), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], 0106 biological sciences, [SDV]Life Sciences [q-bio], Arthrospira platensis, Pharmaceutical Science, macromolecular substances, 04 agricultural and veterinary sciences, Pharmacy, 040401 food science, 01 natural sciences, Analytical Chemistry, Phycocyanin stability, 0404 agricultural biotechnology, 010608 biotechnology, Drug Discovery, Spirulina, Electrochemistry, [CHIM]Chemical Sciences, Encapsulation, Preservatives, Spectroscopy
Abstract: International audience; The cyanobacterium Arthrospira platensis, spirulina, is a source of pigments such as phycobiliprotein, phycocyanin. Phycocyanin is used in the food, cosmetic, and pharmaceutical industries because of its antioxidant, anti-inflammatory, and anticancer properties. The different steps involved in extraction and purification of this protein can alter the final properties. In this review, the stability of phycocyanin (pH, temperature, and light) is discussed, considering the physicochemical parameters of kinetic modeling. The optimal working pH range for phycocyanin is between 5.5 and 6.0 and it remains stable up to 45 °C; however, exposure to relatively high temperatures or acidic pH decreases its half-life and increases the degradation kinetic constant. Phycobiliproteins are sensitive to light and preservatives such as mono- and di-saccharides, citric acid, or sodium chloride appear to be effective stabilizing agents. Encapsulation within nano- or micro-structured materials such as nanofibers, microparticles, or nanoparticles, can also preserve or enhance its stability.
Published: 2022

9. Recognizing the Role of Tropical Seaways in Modulating the Pacific Circulation

Author: N. Tan, Z. S. Zhang, Z. T. Guo, C. C. Guo, Z. J. Zhang, Z. L. He, G. Ramstein, Institute of Geology and Geophysics [Beijing] (IGG), Chinese Academy of Sciences [Beijing] (CAS), Wuhan University [China], NORCE Norwegian Research Center, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), this study was funded by the National Natural Science Foundation of China (NSFC programs 41888101 and 42125502), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grants XDB 26000000 andXDA13010106), NSFC programs 41907371 and 42007398, and the SapienCE (Project 221712) from Norwegian Research Council
Subjects: [PHYS]Physics [physics], Geophysics, [SDU]Sciences of the Universe [physics], General Earth and Planetary Sciences
Abstract: During the late Miocene and the Pliocene, changes in the Central American and Indonesian seaway geometry are very important for ocean circulation and global climate. Various modelling studies have examined the separate effects of these two tropical seaways, especially their link to the onset of the Northern Hemisphere ice sheets through changes in the Atlantic meridional overturning circulation and associated heat and moisture transport. Although the existence of dual tropical seaways is closer to reality, there are very scarce modelling studies exploring the co-effects of dual tropical seaway changes, especially on the Pacific ocean circulation. Here we provide the results of a modelling study on this issue. Our results show that the combined shallow opening of tropical seaways can generate an active Pacific meridional overturning circulation (that is absent in modern conditions) by which the meridional and zonal sea surface temperature gradient in the Pacific largely reduce. In contrast, a deeper opening of tropical seaways cannot produce these changes in the Pacific ocean circulation. This study provides insights into and a better understanding of the role of tropical seaways in shaping the Pacific climate and highlights the importance of the sill depth of each seaway.
Published: 2023

10. Solid‐state NMR characterization of multi‐component intumescent flame retardant polybutylene succinate formulations

Author: Fei Xiao, Gaëlle Fontaine, Kaiyuan Li, Serge Bourbigot, Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Wuhan University [China]
Subjects: Polymers and Plastics, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract: International audience; In this work, a series of multi-component intumescent PBS formulations were elaborated by the combination of intumescent flame retardant (IFR) system (consisting of ethylenediamine phosphate and melamine poly(aluminum phosphate), 7:3, wt:wt) and synergists. Three boron/zinc-containing compounds (i.e., melamine borate, zinc oxide, zinc carbonate) were examined as potential synergists to improve the fire behavior and fire retardancy of PBS. The MLC results showed that the incorporation of all of these compounds enhanced the fire retardancy of PBS to some extent. Among them, zinc oxide exhibited the best fire retardant performances in terms of reduction of the peak heat release rate (pHRR, 61%), fire growth rate index (FIGRA, 19%), maxi- mum average rate of heat emission (MARHE, 55%), and increase of the time to pHRR (+370 s) and to flameout (+650 s) as compared to PBS/IFR10%. Furthermore, the effect of zinc oxide loading on the fire retardancy of PBS was also investigated, the results showed that 2 wt.% loading exhibited the best performances. Solid-state NMR characterization indicated that the presence of ZnO resulted in the formation of a crack-free and dense intumescent char layer reinforced by complex aluminum- zinc-phosphates glassy species. The intumescent char layer provided a protective physical barrier with improved flexibility and cohesion, which effectively limits the heat and mass transfer between condensed and gas phases and hence, improving the fire retardancy of PBS.; Dans ce travail, une série de formulations de PBS intumescents multicomposants ont été élaborées en combinant un système de retardateur de flamme intumescent (IFR) (composé de phosphate d'éthylènediamine et de poly(phosphate d'aluminium) de mélamine, 7:3, wt:wt) et des synergistes. Trois composés contenant du bore et du zinc (borate de mélamine, oxyde de zinc, carbonate de zinc) ont été examinés en tant que synergistes potentiels pour améliorer le comportement au feu et l'ignifugation du PBS. Les résultats de la CLM ont montré que l'incorporation de tous ces composés améliorait dans une certaine mesure l'ignifugation du PBS. Parmi eux, l'oxyde de zinc a présenté les meilleures performances ignifuges en termes de réduction du taux maximal de dégagement de chaleur (pHRR, 61 %), de l'indice de croissance de l'incendie (FIGRA, 19 %), du taux moyen maximal d'émission de chaleur (MARHE, 55 %) et de l'augmentation du temps jusqu'au pHRR (+370 s) et jusqu'à l'extinction de la flamme (+650 s) par rapport au PBS/IFR10 %. En outre, l'effet de la charge d'oxyde de zinc sur l'ignifugation du PBS a également été étudié, les résultats montrant que la charge de 2 % en poids présentait les meilleures performances. La caractérisation par RMN à l'état solide a indiqué que la présence de ZnO entraînait la formation d'une couche de charbon intumescente dense et sans fissures, renforcée par des espèces vitreuses complexes de phosphates d'aluminium et de zinc. La couche de charbon intumescent a fourni une barrière physique protectrice avec une flexibilité et une cohésion améliorées, ce qui limite efficacement le transfert de chaleur et de masse entre les phases condensées et gazeuses et améliore donc le pouvoir ignifuge du PBS.
Published: 2023

11. Adaptive Optimization Method in Digital Twin Conveyor Systems via Range-Inspection Control

Author: Yi Yang, Tian Wang, Fei Tao, Hichem Snoussi, Jiaxiang Cheng, Christian Esposito, Shaanxi University of Science and Technology, School of Automation and Electrical Engineering [Beijing] (University of Science and Technology Beijing), Signal Processing Laboratory (SPL), Wuhan University [China], Laboratorio CINI-Item 'Carlo Savy', Consorzio Interuniversitario Nazionale per l'Informatica (CINI), Laboratoire Modélisation et Sûreté des Systèmes (LM2S), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), and Beihang University (BUAA)
Subjects: 021103 operations research, Optimization problem, Computer science, Adaptive optimization, Control (management), 0211 other engineering and technologies, Control engineering, 02 engineering and technology, Optimal control, Schema (genetic algorithms), Control and Systems Engineering, Robustness (computer science), Conveyor system, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Road map, Electrical and Electronic Engineering, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: International audience; The automated conveyor system, as the core component in the modern manufacturing world, has gained lots of attention from researchers. To optimize the operation of the conveyor system, range-inspection control (RIC) has been considered an efficient strategy to bring this conventional technology to an intelligent level. Various algorithms have been put into use to achieve optimal control. However, the current methodologies are only focusing on control optimization, not scaled into the smart manufacturing framework. The schema of alignment and corporation between the physical and virtual spaces for the system remains an important problem. Therefore, the work in this article aims for an effective framework of implementation between the physical and virtual stations in an automated conveyor system. Since increasingly more application scenarios rely on the digital twin (DT) technology to realize the integration of physical and virtual systems, we proposed the DT automated conveyor system (DT-ACS) that constructs the road map to implement the RIC-based conveyor system under the background of a smart factory. Besides, profit-sharing-based deep Q-networks (PDQNs) have been proposed to cope with the RIC optimization problem. The robustness and efficiency of the proposed PDQN were evaluated via sets of experiments. The discussion and conclusion are presented at last accordingly.
Published: 2022

12. An assessment of L-band surface soil moisture products from SMOS and SMAP in the tropical areas

Author: Hongliang Ma, Xiaojun Li, Jiangyuan Zeng, Xiang Zhang, Jianzhi Dong, Nengcheng Chen, Lei Fan, Morteza Sadeghi, Frédéric Frappart, Xiangzhuo Liu, Mengjia Wang, Huan Wang, Zheng Fu, Zanpin Xing, Philippe Ciais, Jean-Pierre Wigneron, Interactions Sol Plante Atmosphère (UMR ISPA), Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Wuhan University [China], Aerospace Information Research Institute, Chinese Academy of Sciences [Beijing] (CAS), China University of Geosciences [Wuhan] (CUG), Massachusetts Institute of Technology (MIT), Tianjin University (TJU), Southwest University [Chongqing], California Department of Water Resources, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: Rainforests, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Tropics, Soil Science, Geology, Soil moisture, SMAP, Computers in Earth Sciences, Assessment, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, SMOS
Abstract: International audience; Recently, large efforts have been made to develop surface soil moisture (SSM) products based on observations from passive microwave L-band satellites at the global scale. Despite vast previous efforts to assess satellite SSM products based on in situ data, the performance of L-band SSM products remains still little known over the tropical areas including the rainforests. To close this knowledge gap, a comprehensive evaluation of five L-band SSM products from the Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP) satellites, including SMOS-IC, SMAP SCA-V, DCA, and MTDCA, as well as the recently developed SMAP INRAE-BORDEAUX (SMAP-IB) was conducted in tropical areas from 2015 to 2020. The investigation was implemented by using in situ observations, and expanded by the Triple Collocation Analysis (TCA) and double instrumental variable (IVd) methods. The results revealed that all the five L-band SSM products show a good capacity to estimate SSM in most moderately vegetated areas of the tropical areas while they exhibit some uncertainties in dense vegetation (e.g., rainforests). The SSM climatology of the five L-band products in rainforests agreed generally well with that of in situ measurements especially for SMOS-IC (R = 0.75), followed by SMAP-IB (R = 0.72). Notably, the newly developed SMAP-IB shows satisfactory performance in the tropics with the highest R of 0.73 and the smallest unbiased root mean square difference (ubRMSD) of 0.041 m3/m3 from the study based on in situ SM data, and R of >0.81 from the combined TCA/IVd method in most vegetation conditions. SMAP-DCA SSM demonstrates comparable performance to SMAP-SCA-V (R = 0.66) from the in situ based analysis. This study is expected to deepen our understanding on the skill of L-band SSM products in tropical areas and further promote possible upgrades in algorithms and applications in these regions.
Published: 2023

13. Automated Generation of Instruction Set Simulator from Specification

Author: Joloboff, Vania, Liu, Shengpeng, He, Fei, Trustworthy EMbedded PlatfOrms (TEMPO), Laboratoire Franco-Chinois d'Informatique, d'Automatique et de Mathématiques Appliquées (LIAMA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Chinese Academy of Sciences [Changchun Branch] (CAS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institute of Automation - Chinese Academy of Sciences-Centre National de la Recherche Scientifique (CNRS)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Chinese Academy of Sciences [Changchun Branch] (CAS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institute of Automation - Chinese Academy of Sciences-Centre National de la Recherche Scientifique (CNRS)-Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria), Tsinghua University [Beijing] (THU), SAISE, TEMPO, INRIA and Tsinghua University, Prof. Yulin Wang, Wuhan University, China Prof. Yulin Wang, Wuhan University, China and Prof. Sheng-Uei Guan, Xi'an Jiaotong-Liverpool University, China, and Tsinghua University [Beijing]
Subjects: [INFO.INFO-AR]Computer Science [cs]/Hardware Architecture [cs.AR], ACM: I.: Computing Methodologies/I.6: SIMULATION AND MODELING/I.6.8: Types of Simulation/I.6.8.3: Discrete event, ACM: I.: Computing Methodologies/I.6: SIMULATION AND MODELING, Compiler, Hardware Simulation, Instruction Set Simulator, ACM: D.: Software/D.2: SOFTWARE ENGINEERING/D.2.6: Programming Environments/D.2.6.3: Programmer workbench, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Computer Architecture, ACM: I.: Computing Methodologies/I.6: SIMULATION AND MODELING/I.6.7: Simulation Support Systems/I.6.7.0: Environments
Abstract: International audience; We present here an architecture compiler, namely a software that takes as input the description of a processor architecture as it is available from the vendors on their web site, and generates an instruction set simulator for that processor, which can be readily integrated into a simulation framework. This architecture compiler extracts relevant information from the .pdf file, translated into an XML specification. After further XML transformations, the C++ code of the simulator is finally generated. The paper details the approach and the results for the ARM Version 7 processor, that is suitable for other architectures as well.
Published: 2014

14. Multiple morphological profiles from multicomponent- base images for hyperspectral image classification

Author: Xuehua Guan, Jun Li, Jon Atli Benediktsson, Antonio Plaza, Xin Huang, Liangpei Zhang, Mauro Dalla Mura, State Key Lab. of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University [China]-Wuhan University [China], University of Iceland [Reykjavik], Guangdong Key Laboratory for Urbanization and Geo-Simulation, School of Geography and Planning, SUN Yatsen University, Hyperspectral Computing Laboratory (Caceres, Spain), University of Extremadura, GIPSA - Signal Images Physique (GIPSA-SIGMAPHY), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), and Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)
Subjects: Atmospheric Science, Pixel, Contextual image classification, business.industry, Feature vector, Feature extraction, Hyperspectral imaging, Pattern recognition, Independent component analysis, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Principal component analysis, Artificial intelligence, Computers in Earth Sciences, business, Classifier (UML), ComputingMilieux_MISCELLANEOUS, Mathematics
Abstract: Morphological profiles (MPs) are a useful tool for remotely sensed image classification. These profiles are constructed on a base image that can be a single band of a multicomponent remote sensing image. Principal component analysis (PCA) has been used to provide other base images to construct MPs in high-dimensional remote sensing scenes such as hyperspectral images [e.g., by deriving the first principal components (PCs) and building the MPs on the first few components]. In this paper, we discuss several strategies for producing the base images for MPs, and further categorize the considered methods into four classes: 1) linear, 2) nonlinear, 3) manifold learning-based, and 4) multilinear transformation-based. It is found that the multilinear PCA (MPCA) is a powerful approach for base image extraction. That is because it is a tensor-based feature representation approach, which is able to simultaneously exploit the spectral–spatial correlation between neighboring pixels. We also show that independent component analysis (ICA) is more effective for constructing base images than PCA. Another important contribution of this paper is a new concept of multiple MPs (MMPs), aimed at synthesizing the spectral–spatial information extracted from the multicomponent base images, and further enhancing the classification accuracy of MPs. Moreover, we propose two different strategies to interpret the newly proposed MMPs by considering their hyperdimensional feature space: 1) decision fusion and 2) sparse classifier based on multinomial logistic regression (MLR). Experiments conducted on three well-known hyperspectral datasets are used to quantitatively assess the accuracy of different algorithms.
Published: 2014

15. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author: Paulo Augusto Moreira Camargos, Radolslaw Gawlik, Mirko Petrovic, Gunter J. Sturm, Kristof Nekam, Sergio Bonini, Zhanat Ispayeva, Marilyn Urrutia Pereira, Jean Bousquet, Antti Lauerma, Menachem Rottem, Arzu Yorgancioglu, Hubert Blain, Antonio Cherubini, Mário Morais-Almeida, Nathalie Salles, Charlotte G. Mortz, Sylwia Smolinska, Davor Plavec, A. Bedbrook, Torsten Zuberbier, Helga Kraxner, M. Beatrice Bilò, Sinthia Bosnic-Anticevich, Gaëtan Gavazzi, Finbarr C. Martin, Alvaro A. Cruz, K. S. Bennoor, Isabella Annesi-Maesano, Mohamed H. Shamji, Karin Hoffmann-Sommergruber, Marina Atanaskovic-Markovic, Carsten Bindslev-Jensen, Lan Tt Le, Isabel Skypala, Ana Todo-Bom, Vincenzo Patella, Lorenzo Cecchi, Charlotte Suppli Ulrik, Oscar Palomares, Joaquin Sastre, Hans Jürgen Hoffmann, Knut Brockow, Eva Untersmayr, Martin Hrubisko, Bernadette Eberlein, Aziz Sheikh, Milan Sova, Osman M. Yusuf, Violeta Kvedariene, G. Walter Canonica, Dana Wallace, Ioana Agache, Milena Sokolowska, Jos M. G. A. Schols, Susan Waserman, Stéphanie Miot, Carla Irani, Regina E Roller-Winsberger, Michael Levin, Yves Rolland, Emma Montella, Bilun Gemicioglu, Bolesław Samoliński, Stefano Del Giacco, Madda lenaIllario, Yehia El-Gamal, Olga Lourenço, Jean-Christoph Roger J-P Caubet, Luisa Brussino, Marysia Recto, De Yun Wang, Igor Kaidashev, Renaud Louis, Antonino Romano, Mario E. Zernotti, Jacques Reynes, Pedro Carreiro-Martins, Alexandra F. Santos, Marek Niedoszytko, M. Gotua, Musa Khaitov, Thomas B. Casale, Andrea Matucci, Bernardo Sousa-Pinto, Rafael Stelmach, Dejan Dokic, Joana Vitte, Motohiro Ebisawa, Maria Teresa Ventura, Joaquim Mullol, Tomas Chivato, Petr Panzner, Oliver Pfaar, Sanna Toppila-Salmi, Ioanna Tsiligianni, Wytske Fokkens, Alessandra Vultaggio, H. Neffen, Juan Carlos Ivancevich, Ya-dong Gao, Anna Sediva, Maja Hofmann, Ana Maria Carriazo, João Fonseca, Marek Jutel, A. Benetos, Nhân Pham-Thi, Mona Al-Ahmad, Arunas Valiulis, Mihaela Zidarn, Elizabeth Angier, Yoshitaka Okamoto, Montserrat Fernandez-Rivas, Cezmi A. Akdis, Philip W. Rouadi, Olivier Guérin, John Farrell, Mikaela Odemyr, George Christoff, Vera Mahler, Claus Bachert, Edward F. Knol, Wienczyslawa Czarlewski, Robyn E O'Hehir, Victoria Cardona, Ludger Klimek, Tari Haahtela, Vincent Le Moing, Branislava Milenkovic, Carmen Rondon, Kaja Julge, Jolanta Walusiak-Skorupa, Nikolaos G. Papadopoulos, Aslı Gelincik, Markus Ollert, Piotr Kuna, Leyla Namazova-Baranova, Margitta Worm, Annick Barbaud, Elena Camelia Berghea, Todor A. Popov, Derek K. Chu, María José Torres, Faradiba Sarquis Serpa, Nicola Scichilone, Amir Hamzah Abdul Latiff, Frederico S. Regateiro, Gianni Passalacqua, Humboldt-Universität zu Berlin, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Humboldt University Of Berlin, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Transylvania University, Wrocław Medical University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Cagliari, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Università Politecnica delle Marche [Ancona] (UNIVPM), Medical Consulting Czarlewski, Universiti Putra Malaysia, University of Southampton, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Belgrade [Belgrade], Ghent University Hospital, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Dhaka Shishu Hospital [Bangladesh], University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Odense University Hospital (OUH), Italian National Research Council, National Research Council [Italy] (CNR), The University of Sydney, Technische Universität München = Technical University of Munich (TUM), Università degli studi di Torino = University of Turin (UNITO), Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG), IRCCS Research Hospital, Milan, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, University of South Florida [Tampa] (USF), Geneva University Hospital (HUG), Azienda Usl Toscana centro [Firenze], Софийски университет = Sofia University, McMaster University [Hamilton, Ontario], State University of Bahia, Institute of Public Health of Republic of North Macedonia [Skopje], Ain Shams University (ASU), Sagamihara National Hospital [Kanagawa, Japan], Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Amsterdam UMC - Amsterdam University Medical Center, Universidade do Porto = University of Porto, Wuhan University [China], CHU Grenoble, Silesian University of Medicine, Istanbul Faculty of Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Centre Hospitalier Universitaire de Nice (CHU Nice), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Medizinische Universität Wien = Medical University of Vienna, Aarhus University [Aarhus], Oncology Institute of St Elisabeth, University of Naples Federico II = Università degli studi di Napoli Federico II, St Joseph University, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Kazakh National Medical University, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Tartu University Institute of Clinical Medicine, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Federal Medicobiological Agency [Moscow, Russian Federation], University Medical Center [Utrecht], Semmelweis University [Budapest], Medical University of Łódź (MUL), Vilnius University [Vilnius], University of Medicine and Pharmacy (VIETNAM), University of Cape Town, CHU Sart Tilman, Université de Liège, University of Beira Interior [Portugal] (UBI), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), uBibliorum, Ear, Nose and Throat, AII - Inflammatory diseases, CHU Montpellier, Wroclaw Medical University [Wrocław, Pologne], University of Bari Aldo Moro (UNIBA), Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sagamihara National Hospital, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Toulouse [Toulouse], RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Bousquet J., Agache I., Blain H., Jutel M., Ventura M.T., Worm M., Del Giacco S., Benetos A., Bilo B.M., Czarlewski W., Abdul Latiff A.H., Al-Ahmad M., Angier E., Annesi-Maesano I., Atanaskovic-Markovic M., Bachert C., Barbaud A., Bedbrook A., Bennoor K.S., Berghea E.C., Bindslev-Jensen C., Bonini S., Bosnic-Anticevich S., Brockow K., Brussino L., Camargos P., Canonica G.W., Cardona V., Carreiro-Martins P., Carriazo A., Casale T., Caubet J.-C., Cecchi L., Cherubini A., Christoff G., Chu D.K., Cruz A.A., Dokic D., El-Gamal Y., Ebisawa M., Eberlein B., Farrell J., Fernandez-Rivas M., Fokkens W.J., Fonseca J.A., Gao Y., Gavazzi G., Gawlik R., Gelincik A., Gemicioglu B., Gotua M., Guerin O., Haahtela T., Hoffmann-Sommergruber K., Hoffmann H.J., Hofmann M., Hrubisko M., Illario M., Irani C., Ispayeva Z., Ivancevich J.C., Julge K., Kaidashev I., Khaitov M., Knol E., Kraxner H., Kuna P., Kvedariene V., Lauerma A., Le L.T.T., Le Moing V., Levin M., Louis R., Lourenco O., Mahler V., Martin F.C., Matucci A., Milenkovic B., Miot S., Montella E., Morais-Almeida M., Mortz C.G., Mullol J., Namazova-Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Okamoto Y., Ollert M., Palomares O., Papadopoulos N.G., Panzner P., Passalacqua G., Patella V., Petrovic M., Pfaar O., Pham-Thi N., Plavec D., Popov T.A., Recto M.T., Regateiro F.S., Reynes J., Roller-Winsberger R.E., Rolland Y., Romano A., Rondon C., Rottem M., Rouadi P.W., Salles N., Samolinski B., Santos A.F., S Sarquis F., Sastre J., M. G. A. Schols J., Scichilone N., Sediva A., Shamji M.H., Sheikh A., Skypala I., Smolinska S., Sokolowska M., Sousa-Pinto B., Sova M., Stelmach R., Sturm G., Suppli Ulrik C., Todo-Bom A.M., Toppila-Salmi S., Tsiligianni I., Torres M., Untersmayr E., Urrutia Pereira M., Valiulis A., Vitte J., Vultaggio A., Wallace D., Walusiak-Skorupa J., Wang D.-Y., Waserman S., Yorgancioglu A., Yusuf O.M., Zernotti M., Zidarn M., Chivato T., Akdis C.A., Zuberbier T., Klimek L., HUS Inflammation Center, University of Helsinki, and Department of Dermatology, Allergology and Venereology
Subjects: Male, Allergy, Pediatrics, Eaaci Position Paper, COVID-19 vaccines, older (adults, GUIDELINES, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Immunology and Allergy, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Geriatrics, MESH: Aged, RISK, Vaccines, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, people), EPINEPHRINE, Epinephrine, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, COVID -19 vaccines, Anaphylaxis, medicine.drug, older (adults/people), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), MESH: Covid-19, MESH: Epinephrine, Immunology, adrenaline, anaphylaxis, Aged, COVID-19 Vaccines, Humans, SARS-CoV-2, COVID-19, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diabetes mellitus, Anaphylaxis/etiology, MESH: SARS-CoV-2, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, COVID‐19 vaccines, Older - Adults/people, Asthma, MESH: Humans, business.industry, adrenaline, anaphylaxis, COVID-19 vaccines, older (adults/people), medicine.disease, Obesity, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, MESH: Anaphylaxis, Older, 3121 General medicine, internal medicine and other clinical medicine, business, MESH: Covid-19 vaccines, 030215 immunology
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Published: 2021

16. Individual tree extraction from terrestrial laser scanning data via graph pathing

Author: Xinlian Liang, Olivier Martin-Ducup, Gislain Ii Mofack, Di Wang, Xidian University, Wuhan University [China], Université de Yaoundé I, Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: 0106 biological sciences, Graph pathing, Mean squared error, Computer science, Point cloud, computer.software_genre, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, 010603 evolutionary biology, 01 natural sciences, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Segmentation, Forest plot, Ecology, Evolution, Behavior and Systematics, QH540-549.5, Nature and Landscape Conservation, Ecology, Intersection (set theory), Forestry, 15. Life on land, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Tree (graph theory), Path (graph theory), Benchmark (computing), Graph (abstract data type), Data mining, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Tree extraction, computer, 010606 plant biology & botany
Abstract: International audience; Background: Individual tree extraction from terrestrial laser scanning (TLS) data is a prerequisite for tree-scale estimations of forest biophysical properties. This task currently is undertaken through laborious and time-consuming manual assistance and quality control. This study presents a new fully automatic approach to extract single trees from large-area TLS data. This data-driven method operates exclusively on a point cloud graph by path finding, which makes our method computationally efficient and universally applicable to data from various forest types. Results: We demonstrated the proposed method on two openly available datasets. First, we achieved state-of-the-art performance on locating single trees on a benchmark dataset by significantly improving the mean accuracy by over 10% especially for difficult forest plots. Second, we successfully extracted 270 trees from one hectare temperate forest. Quantitative validation resulted in a mean Intersection over Union (mIoU) of 0.82 for single crown segmentation, which further led to a relative root mean square error (RMSE%) of 21.2% and 23.5% for crown area and tree volume estimations, respectively. Conclusions: Our method allows automated access to individual tree level information from TLS point clouds. The proposed method is free from restricted assumptions of forest types. It is also computationally efficient with an average processing time of several seconds for one million points. It is expected and hoped that our method would contribute to TLS-enabled wide-area forest qualifications, ranging from stand volume and carbon stocks modelling to derivation of tree functional traits as part of the global ecosystem understanding.
Published: 2021

17. Effect of Sodium Concentration on the Synthesis of Faujasite by Two-step Synthesis Procedure

Author: Chunzheng Wang, Svetlana Mintova, Hailing Guo, Lei Zhao, Lijuan Wang, Ge Yang, Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), China University of Petroleum, School of Mathematics and Statistics [Wuhan], Wuhan University [China], Laboratoire catalyse et spectrochimie (LCS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), and Nantes Université (NU)-Université de Rennes 1 (UR1)
Subjects: Materials science, synthesis, Sodium, chemistry.chemical_element, 02 engineering and technology, engineering.material, 010402 general chemistry, 01 natural sciences, law.invention, chemistry.chemical_compound, Aluminosilicate, law, morphology, [CHIM]Chemical Sciences, zeolite, alkali metal, Crystallization, Zeolite, General Chemistry, Faujasite, 021001 nanoscience & nanotechnology, Alkali metal, 0104 chemical sciences, Amorphous solid, chemistry, Sodium hydroxide, engineering, 0210 nano-technology, Nuclear chemistry
Abstract: International audience; The relationship between concentration of sodium cations and the properties of faujasite (FAU) zeolite using a two-step synthesis procedure including (1) formation of amorphous aluminosilicate precursors and separation of amorphous nanoparticles, and (2) transformation of these amorphous particles into zeolite crystals by treatment with alkali solutions (NaOH) were studied. Three representative samples including two nano-sized zeolites and one micron-sized zeolite were prepared using different concentration of sodium hydroxide. The crystallization process of these zeolites was studied in details by FTIR, NMR, XRD, SEM, TEM, N 2 adsorption. The results indicated that minor changes in the concertation of inorganic cations can significantly shorten the induction period and crystallization time and thus affect the morphology, size and chemical composition of the zeolite crystals.
Published: 2021

18. Effect of Co-Existing Cations and Anions on the Adsorption of Antibiotics on Iron-Containing Minerals

Author: Xiaoyu Guan, Juntao Guo, Hui Zhang, Shiyong Tao, Gilles Mailhot, Feng Wu, Jing Xu, Wuhan University [China], Institut de Chimie de Clermont-Ferrand (ICCF), and SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)
Subjects: Minerals, Sulfonamides, Iron, Organic Chemistry, Pharmaceutical Science, Water, co-existing ions, Quinolones, antibiotics, iron-containing minerals, adsorption, natural surface water, Ferrosoferric Oxide, Analytical Chemistry, Anti-Bacterial Agents, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Chemistry (miscellaneous), antibiotics iron-containing minerals adsorption co-existing ions natural surface water, Cations, Drug Discovery, Molecular Medicine, Adsorption, Physical and Theoretical Chemistry, Kaolin
Abstract: The adsorption of antibiotics on minerals is an important process in their environment behavior. The adsorption behavior of antibiotics on iron-containing minerals and the effect of co-existing cations and anions were studied in this work. Magnetite, hematite, goethite and kaolin were selected as the representative minerals and characterized by SEM, XRD and BET. A total of eight antibiotics, including three quinolones, three sulfonamides and two mycins were chosen as the research targets. Results showed a higher adsorption amount of quinolones than that of sulfonamides and mycins on the surface of iron-containing minerals in most mineral systems. The adsorption isotherms of quinolones can be well fitted using the Freundlich models. The effects of five cations and five anions on the adsorption of quinolones were investigated, among which Mg2+, Ca2+, HCO3− and H2PO4− mainly showed significant inhibition on the adsorption, while the effects of K+, Na+, NH4+, Cl−, NO3− and SO42− showed less. Natural surface water samples were also collected and used as media to investigate the adsorption behavior of quinolones on iron-containing minerals. The buffering capacity of the natural water kept the reaction solution at circumneutral conditions, and the adsorption amount was mostly promoted in the goethite system (from 0.56~0.78 μmol/g to 0.52~1.43 μmol/g), but was inhibited in the other systems (magnetite: from 1.13~1.33 μmol/g to 0.45~0.76 μmol/g; hematite: from 0.52~0.65 μmol/g to 0.02~0.18 μmol/g; kaolin: from 1.98~1.99 μmol/g to 0.90~1.40 μmol/g). The results in this work help to further understand the transportation and fate of antibiotics in an aqueous environment.
Published: 2022

19. 3D dynamic spatiotemporal atlas of the vocal tract during consonant-vowel production from 2D real time MRI

Author: Ioannis K. Douros, Yu Xie, Chrysanthi Dourou, Karyna Isaieva, Pierre-André Vuissoz, Jacques Felblinger, Yves Laprie, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Speech Modeling for Facilitating Oral-Based Communication (MULTISPEECH), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Zhongnan Hospital, Wuhan University [China], National Technical University of Athens [Athens] (NTUA), Centre d'Investigation Clinique - Innovation Technologique [Nancy] (CIC-IT), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), ANR-15-CE23-0024,ArtSpeech,Synthèse Articulatoire Phonétique(2015), Laprie, Yves, and Interactions humain-machine, objets connectés, contenus numériques, données massives et connaissance - Synthèse Articulatoire Phonétique - - ArtSpeech2015 - ANR-15-CE23-0024 - AAPG2015 - VALID
Subjects: spatiotemporal atlas, [INFO.INFO-CL] Computer Science [cs]/Computation and Language [cs.CL], generic speaker model, adaptive gaussian kernel, Radiology, Nuclear Medicine and imaging, Computer Vision and Pattern Recognition, Electrical and Electronic Engineering, Computer Graphics and Computer-Aided Design, [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: In this work, we address the problem of creating a 3D dynamic atlas of the vocal tract that captures the dynamics of the articulators in all three dimensions in order to create a global speaker model independent of speaker-specific characteristics. The core steps of the proposed method are the temporal alignment of the real-time MR images acquired in several sagittal planes and their combination with adaptive kernel regression. As a preprocessing step, a reference space was created to be used in order to remove anatomical information of the speakers and keep only the variability in speech production for the construction of the atlas. The adaptive kernel regression makes the choice of atlas time points independently of the time points of the frames that are used as an input for the construction. The evaluation of this atlas construction method was made by mapping two new speakers to the atlas and by checking how similar the resulting mapped images are. The use of the atlas helps in reducing subject variability. The results show that the use of the proposed atlas can capture the dynamic behavior of the articulators and is able to generalize the speech production process by creating a universal-speaker reference space.
Published: 2022

20. How meso shear chains bridge multiscale shear behaviors in granular materials: a preliminary study

Author: Jiaying Liu, Antoine Wautier, François Nicot, Félix Darve, Wei Zhou, Zhejiang University City College, Zhejiang Engineering Research Center of Intelligent Urban Infrastructure, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Wuhan University [China], Natural Science Foundation of Zhejiang Province : LY22E090002, and National Natural Science Foundation of China under Grant No. 51909194 and No. 51908193
Subjects: contact sliding, Applied Mathematics, Mechanical Engineering, granular materials, shear chain, [SPI.GCIV.GEOTECH]Engineering Sciences [physics]/Civil Engineering/Géotechnique, DEM, particle rotation, [SPI.MECA.SOLID]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Solid mechanics [physics.class-ph], [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, Condensed Matter Physics, shear band, Mechanics of Materials, Modeling and Simulation, General Materials Science
Abstract: International audience; The "incremental shear strain chain" concept (simply called "shear chain") has been proposed recently to quantitatively account for local kinematic features of granular materials. At the microscopic scale, contacts can slide and particles can rotate; while at the macroscopic scale, shear bands appear as a typical localized failure mode. Despite visual spatial distribution features, the direct links from microscopic to macroscopic shear behaviors are still missing. This paper investigates shear characteristics appearing at the micro, meso and macro scales in granular materials, and tries to elucidate how they can be correlated by adopting the shear chain concept. Based on the spatial statistics tools, the shear chain and the shear band orientations are compared by demonstrating that the shear band is influenced by the sample aspect ratio while shear chain orientation only depends on the stress state. Shear chains experience a relative steady and high fabric anisotropy, irrespective to the stress state. Micro contact sliding and particle rotation mainly exist in the shear chain connection positions, which gives possible clues on shear chain forming. In conclusion, the shear band is eventually conjectured to be formed of a collection of crossing shear chains at meso scale, according to detailed analysis and discussion on the correlations of shear behaviors across scales.
Published: 2022

21. The Role of the Real Estate Sector in the Structural Dynamics of the Chinese Economy: An Input–Output Analysis

Author: Jamal Khan, Umair Shad, Eric Girardin, Yongming Huang, Wuhan University [China], Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Hazara University Mansehra (HU), and Social Science Foundation Project of China Ministry of Education (No. 17YJC790184)
Subjects: Input–output model, 050204 development studies, 05 social sciences, Real estate, Linkage (mechanical), [SHS.ECO]Humanities and Social Sciences/Economics and Finance, law.invention, Work (electrical), law, Urbanization, 0502 economics and business, Value (economics), Economics, 050207 economics, Economic system, Chinese economy, China, General Economics, Econometrics and Finance
Abstract: International audience; Market-oriented housing reforms and the rapid urbanization process have led to spectacular growth in the Chinese real estate sector (RES). However, the changes in the role played by this sector in the structural dynamics of the Chinese economy have not been examined sufficiently. Accordingly, we analyze the intersectoral structural changes to the Chinese RES, its linkages with the rest of the economy, and its growth sources, using four Chinese input–output tables from 2002 to 2017. We depart from existing work on the RES by using the causative matrix approach and structural decomposition analysis, and obtain three main results. First, the RES, which received little non-RES feedback during the 2002–2007 period, has subsequently received much more substantial feedback. Second, the impact of the RES on China's economic growth stems mainly from its forward linkages. Third, the growth in the RES has been driven mainly by domestic demand expansion. Our results highlight that the Chinese RES, which plays a key role in value chains, is highly dependent on its own final demand and a fall in its demand would impede economic development. An important implication of these results is that developing the national economy by stimulating the RES would not be as effective as developing the RES through stimulating the national economy.
Published: 2021

22. Radiation-Induced Degradation Analysis and Reliability Modeling of COTS ADCs for Space-Borne Miniature Fiber-Optic Gyroscopes

Author: Jing Jin, Kun Ma, Enrico Zio, Linghai Kong, Jiliang He, Xiaowei Wang, Ningfang Song, Beihang University (BUAA), Centre de recherche sur les Risques et les Crises (CRC), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Politecnico di Milano [Milan] (POLIMI), Kyung Hee University (KHU), Tsinghua University [Beijing] (THU), City University of Hong Kong [Hong Kong] (CUHK), and Wuhan University [China]
Subjects: Optical fiber, Computer science, Space-borne interferometric fiber-optic gyroscopes, 02 engineering and technology, law.invention, Degradation, Signal-to-noise ratio, Reliability (semiconductor), law, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, [SHS.GEST-RISQ]Humanities and Social Sciences/domain_shs.gest-risq, Electrical and Electronic Engineering, Aerospace, Instrumentation, ComputingMilieux_MISCELLANEOUS, Commercial off-the-shelf (COTS) analog-to-digital converters (ADCs), business.industry, 020208 electrical & electronic engineering, Reliability modeling, Gyroscope, Interferometry, Orbit, Radiation acceleration test, Geostationary orbit, business, Space environment, Degradation (telecommunications)
Abstract: Respecting the requirements of lightweight, small size, low power consumption and especially low cost, commercial off-the-shelf (COTS) analog-to-digital converters (ADCs) are gradually being used to replace specifically designed aerospace -grade ones in space-borne miniature interferometric fiber-optic gyroscopes (IFOGs). However, the total ionizing dose (TID) effect of $\gamma $ -ray radiation in the space environment may cause the damage of COTS ADCs, and lead to performance degradation and even the failure. In order to measure the safety of COTS ADCs in IFOGs under the TID effect, the radiation-induced degradation model and the corresponding reliability model are proposed in this work. First of all, the relationship between the degradation of COTS ADCs and the IFOG’s angular random walk (ARW) is deduced. Then, a radiation accelerated test is designed and performed, with a real-time, dynamic data acquisition method based on the first-input-first-output (FIFO) memories to determine the degradation of COTS ADCs. Finally, a degradation path model is established based on the degradation data, and the reliability of COTS ADCs used for space-borne IFOGs is further obtained by using the Monte Carlo method. An engineering application is introduced to show the effectiveness of the proposed model, and the results show that the reliability of the experimental COTS ADCs makes them usable for the space-borne miniature IFOGs in low-earth orbit (LEO) and geostationary earth orbit (GEO) space missions.
Published: 2021

23. A new Graphical User Interface for the CONTSID toolbox for Matlab

Author: H. Muller, Marion Gilson, Fengwei Chen, Hugues Garnier, Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Université de Lorraine (UL), Wuhan University [China], IFAC, Garnier, Hugues, and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0209 industrial biotechnology, business.industry, Computer science, 020208 electrical & electronic engineering, System identification, 02 engineering and technology, computer.software_genre, MESH: black-box model, continuous-time model, data-driven modelling, graphical user interface, Matlab toolbox, software tools, system identification, Toolbox, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Model validation, Identification (information), [SPI.AUTO] Engineering Sciences [physics]/Automatic, 020901 industrial engineering & automation, Model parameter, Transfer function model, Control and Systems Engineering, 0202 electrical engineering, electronic engineering, information engineering, Data mining, business, MATLAB, computer, Graphical user interface, computer.programming_language
Abstract: International audience; The main purpose of this contribution is to describe the new features of the latest version 7.4 of the CONtinuous-Time System IDentification (CONTSID) toolbox for Matlab. The main addition is a new Graphical User Interface (GUI), which allows the user in a friendly and easy way to perform data analysis, model parameter estimation as well as model validation. The recent additions for MISO time-delay transfer function model identification are also briefly introduced.
Published: 2021

24. Pressure effects on morphology of isotropic char layer, shrinkage, cracking and reduced heat transfer of wooden material

Author: Kaiyuan Li, Serge Bourbigot, Yanyan Zou, Jie Ji, Xianfeng Chen, Université de Lille, CNRS, INRA, ENSCL, Wuhan University [China], BRANZ [New Zealand], Unité Matériaux et Transformations - UMR 8207 [UMET], University of Science and Technology of China [Hefei] [USTC], Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), University of Science and Technology of China [Hefei] (USTC), European Project: 670747,H2020,ERC-2014-ADG,FireBar-Concept(2016), and Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Materials science, 020209 energy, General Chemical Engineering, 02 engineering and technology, Char, Thermal conductivity, Heat transfer, Pressure, 0202 electrical engineering, electronic engineering, information engineering, Physical and Theoretical Chemistry, Composite material, Shrinkage, Wood, Pyrolysis, Mechanical Engineering, Internal pressure, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Cracking, [CHIM.POLY]Chemical Sciences/Polymers, 0210 nano-technology, Ambient pressure
Abstract: International audience; Using a compartment with adjustable oxygen concentration and internal pressure, the shrinkage and cracking of isotropic char layer during pyrolysis were studied by pyrolyzing the medium density fibreboard (MDF) in inert atmosphere with different ambient pressures. The experimental results have shown that the ambient pressure has insignificant effect on shrinkage although some trends have been identified. Therefore, the reduction of tensile strength of material dominates the char cracking under low pressures, leading to noticeableincrease in the number of char fissures. The char shrinkage could expose the raw material beneath the char layer and enhance the radiative heat transfer at the sample surface (by fissure width instead of number), which is modeled using a modified thermal conductivity as the typical simplification. It is found that the mass loss rate at the early pyrolysis stage increases up to 20% with increasing width of char fissures. However, the external radiation can only affect a limited depth in the near surface zone which is found less than 3 mm in the current experiments. The thermal conductivity under near regular pressure could be over 2 times higher than its value under low pressure (30 kPa) and with which the differences in the first peaks of mass loss rate under different pressures can be well predicted.
Published: 2021

25. The Pathophysiology of Long COVID throughout the Renin-Angiotensin System

Author: Shaymaa Khazaal, Julien Harb, Mohamad Rima, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Ziad Abi Khattar, Christian Legros, Hervé Kovacic, Ziad Fajloun, Jean-Marc Sabatier, University of Balamand [Liban] (UOB), Azm Center for research in biotechnology and its applications [TRIPOLI], Université Libanaise, Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Nantes Université - UFR Lettres et Langages (Nantes Univ - UFR LL), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Wuhan University [China], MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de neurophysiopathologie (INP), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Long COVID, infectious disease, [SDV]Life Sciences [q-bio], Pharmaceutical Science, Angiotensin II receptor type 1, renin-angiotensin system, MESH: Angiotensin-Converting Enzyme 2, Peptidyl-Dipeptidase A, Angiotensin II receptor type 2, Analytical Chemistry, immunity disorders, Post-Acute COVID-19 Syndrome, angiotensin-converting enzyme 2, MESH: Renin-Angiotensin System, Drug Discovery, Humans, MESH: COVID-19, MESH: SARS-CoV-2, Physical and Theoretical Chemistry, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, MESH: Humans, SARS-CoV-2, Organic Chemistry, COVID-19, MESH: Peptidyl-Dipeptidase A, MESH: Post-Acute COVID-19 Syndrome, Chemistry (miscellaneous), Molecular Medicine
Abstract: COVID-19 has expanded across the world since its discovery in Wuhan (China) and has had a significant impact on people’s lives and health. Long COVID is a term coined by the World Health Organization (WHO) to describe a variety of persistent symptoms after acute SARS-CoV-2 infection. Long COVID has been demonstrated to affect various SARS-CoV-2-infected persons, independently of the acute disease severity. The symptoms of long COVID, like acute COVID-19, consist in the set of damage to various organs and systems such as the respiratory, cardiovascular, neurological, endocrine, urinary, and immune systems. Fatigue, dyspnea, cardiac abnormalities, cognitive and attention impairments, sleep disturbances, post-traumatic stress disorder, muscle pain, concentration problems, and headache were all reported as symptoms of long COVID. At the molecular level, the renin-angiotensin system (RAS) is heavily involved in the pathogenesis of this illness, much as it is in the acute phase of the viral infection. In this review, we summarize the impact of long COVID on several organs and tissues, with a special focus on the significance of the RAS in the disease pathogenesis. Long COVID risk factors and potential therapy approaches are also explored.
Published: 2022

26. Heat kernel and gradient estimates for kinetic SDEs with low regularity coefficients

Author: P.E. Chaudru de Raynal, S. Menozzi, A. Pesce, X. Zhang, Département de Mathématiques et Informatique - Université de Nantes, Université de Nantes (UN), Laboratoire de Mathématiques et Modélisation d'Evry (LaMME), Université d'Évry-Val-d'Essonne (UEVE)-ENSIIE-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Wuhan University [China], and Université de Bologne
Subjects: parametrix MSC: 60H10, degenerate Kolmogorov equations, General Mathematics, heat kernel and gradient estimates, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Mathematics - Analysis of PDEs, 34F05, degenerate Kolmogorov kinetic equations, kinetic dynamics, FOS: Mathematics, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], 60H10,34F05, parametrix, Analysis of PDEs (math.AP)
Abstract: We establish heat kernel and gradient estimates for the density of kinetic degenerate Kolmogorov stochastic differentia equations. Our results are established under somehow minimal assumptions that guarantee the SDE is weakly well posed.
Published: 2022

27. AoA-Aware Probabilistic Indoor Location Fingerprinting Using Channel State Information

Author: Luan Chen, Iness Ahriz, Didier Le Ruyet, CEDRIC. Traitement du signal et architectures électroniques (CEDRIC - LAETITIA), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Wuhan University [China]
Subjects: Signal Processing (eess.SP), Computer Networks and Communications, Computer science, RSS, Internet of Things, 02 engineering and technology, computer.software_genre, 0203 mechanical engineering, Angle of arrival, location fingerprinting, FOS: Electrical engineering, electronic engineering, information engineering, 0202 electrical engineering, electronic engineering, information engineering, Wireless, Electrical Engineering and Systems Science - Signal Processing, channel state information, business.industry, Probabilistic logic, Physical layer, 020206 networking & telecommunications, 020302 automobile design & engineering, computer.file_format, Angle of Arrival, [SPI.TRON]Engineering Sciences [physics]/Electronics, Computer Science Applications, Wireless site survey, Hardware and Architecture, Channel state information, Signal Processing, Data mining, entropy, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, computer, Information Systems
Abstract: International audience; With expeditious development of wireless communications, location fingerprinting (LF) has nurtured considerable indoor location-based services (ILBSs) in the field of the Internet of Things (IoT). For most pattern-matching-based LF solutions, previous works either appeal to the simply received signal strength (RSS), which suffers from dramatic performance degradation due to sophisticated environmental dynamics, or rely on the fine-grained physical layer channel state information (CSI), whose intricate structure leads to increased computational complexity. Meanwhile, the harsh indoor environment can also breed similar radio signatures among certain predefined reference points (RPs), which may be randomly distributed in the area of interest, thus mightily tampering the location mapping accuracy. To work out these dilemmas, during the offline site survey, we first adopt autoregressive (AR) modeling entropy of CSI amplitude as location fingerprint, which shares the structural simplicity of RSS while reserving the most location-specific statistical channel information. Moreover, an additional Angle-of-Arrival (AoA) fingerprint can be accurately retrieved from the CSI phase through an enhanced subspace-based algorithm, which serves to further eliminate the error-prone RP candidates. In the online phase, by exploiting both CSI amplitude and phase information, a novel bivariate kernel regression scheme is proposed to precisely infer the target’s location. Results from extensive indoor experiments validate the superior localization performance of our proposed system over previous approaches.
Published: 2020

28. Data-Driven Modeling of Wireless Power Transfer Systems With Slowly Time-Varying Parameters

Author: Fengwei Chen, Peter C. Young, Arturo Padilla, Hugues Garnier, Wuhan University [China], Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre for Research on Environmental Systems and Statistics (CRES), and Lancaster University
Subjects: Index Terms-Data-driven modeling, Basis (linear algebra), Computer science, 020208 electrical & electronic engineering, Mode (statistics), System identification, 02 engineering and technology, Function (mathematics), time delay, time-varying parameter, wireless power transfer (WPT), Data-driven, Nonlinear system, Control theory, 0202 electrical engineering, electronic engineering, information engineering, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Wireless power transfer, Electrical and Electronic Engineering, system identification, recursive estimation
Abstract: International audience; This paper considers the data-driven modeling of a class of phase-controlled wireless power transfer (WPT) systems, where the load may vary slowly with respect to time. The dominant mode analysis suggests that a model of the Hammerstein type, which consists of a static nonlinearity function, followed by a linear time-varying model with a pure time delay, is the best structure to describe the input-output relationship of the system. On this basis, we derive a small-signal model that is linear in the variables in order to aid control design and allow the associated model parameters to be estimated from sampled input-output data using the standard refined instrumental variable (RIV) method. In the presence of a time-varying load, however, the plant model parameters may not be correctly estimated if the load response is not removed. In order to address this problem, a new recursive RIV method is proposed, in which an effective technique is introduced to track the load response, so allowing the parameters and time delay of the time-varying model to be accurately estimated. The effectiveness of the proposed method is verified by applying it to both a simulation model and a laboratory system.
Published: 2020

29. Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic

Author: Bruno Riou, Yan Zhao, Gilles Hejblum, Nathanael Lapidus, Fabrice Carrat, Xianlong Zhou, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Wuhan University [China], Unité de recherche sur les maladies cardiovasculaires et métaboliques, UMR S 1166, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Gestionnaire, HAL Sorbonne Université 5
Subjects: medicine.medical_specialty, China, Coronavirus disease 2019 (COVID-19), Unbiased Estimation, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, 01 natural sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Intensive care, Anesthesiology, Pandemic, Medicine, 030212 general & internal medicine, 0101 mathematics, Pandemics, Estimation, Intensive care units, business.industry, Research, 010102 general mathematics, lcsh:Medical emergencies. Critical care. Intensive care. First aid, COVID-19, lcsh:RC86-88.9, Intensive care unit, Bed Occupancy, 3. Good health, Statistical models, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Emergency medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Estimation methods, business
Abstract: Background The average length of stay (LOS) in the intensive care unit (ICU_ALOS) is a helpful parameter summarizing critical bed occupancy. During the outbreak of a novel virus, estimating early a reliable ICU_ALOS estimate of infected patients is critical to accurately parameterize models examining mitigation and preparedness scenarios. Methods Two estimation methods of ICU_ALOS were compared: the average LOS of already discharged patients at the date of estimation (DPE), and a standard parametric method used for analyzing time-to-event data which fits a given distribution to observed data and includes the censored stays of patients still treated in the ICU at the date of estimation (CPE). Methods were compared on a series of all COVID-19 consecutive cases (n = 59) admitted in an ICU devoted to such patients. At the last follow-up date, 99 days after the first admission, all patients but one had been discharged. A simulation study investigated the generalizability of the methods' patterns. CPE and DPE estimates were also compared to COVID-19 estimates reported to date. Results LOS ≥ 30 days concerned 14 out of the 59 patients (24%), including 8 of the 21 deaths observed. Two months after the first admission, 38 (64%) patients had been discharged, with corresponding DPE and CPE estimates of ICU_ALOS (95% CI) at 13.0 days (10.4–15.6) and 23.1 days (18.1–29.7), respectively. Series' true ICU_ALOS was greater than 21 days, well above reported estimates to date. Conclusions Discharges of short stays are more likely observed earlier during the course of an outbreak. Cautious unbiased ICU_ALOS estimates suggest parameterizing a higher burden of ICU bed occupancy than that adopted to date in COVID-19 forecasting models. Funding Support by the National Natural Science Foundation of China (81900097 to Dr. Zhou) and the Emergency Response Project of Hubei Science and Technology Department (2020FCA023 to Pr. Zhao).
Published: 2020

30. Macroscopic softening in granular materials from a mesoscale perspective

Author: Stéphane Bonelli, Antoine Wautier, François Nicot, Félix Darve, Jiaying Liu, State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University [China], Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Aix Marseille Université (AMU), Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Grenoble Alpes (UGA), Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and National Key R&D Program of China (No. 2018YFC1508500), China Scholarship Council (Joint PhD program, No. 201606270088) and China Postdoctoral Science Foundation (No. 2018M642910)
Subjects: Dilatant, softening, Materials science, granular materials, Mesoscale meteorology, strain localization, 02 engineering and technology, Granular material, rotation, [SPI]Engineering Sciences [physics], 0203 mechanical engineering, force chains, General Materials Science, Force chain, Softening, Mesoscopic physics, Applied Mathematics, Mechanical Engineering, DEM, mesomechanics, Mechanics, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 020303 mechanical engineering & transports, Mechanics of Materials, Modeling and Simulation, Hardening (metallurgy), 0210 nano-technology, Shear band
Abstract: Stress-oftening is one of the significant features experienced by cohesive-frictional granular materials subjected to deviatoric loading. This paper focuses on mesoscopic evolutions of the dense granular assembly during a typical drained biaxial test conducted by DEM, and proposes mesoscopically-based framework to interpret both hardening and softening mechanisms. In this context, force chains play a fundamental role as they form the strong contact phase in granular materials. Their geometrical and mechanical characteristics, as well as the surrounding structures, are defined and analyzed in terms of force chain bending evolution, local dilatancy, rotation and non-coaxiality between the principal stress and the geometrical orientation of force chains. By distinguishing two zones inside and outside shear band, force chain rotations are shown to be of opposite sign, which may contribute to the observed macroscopic softening as one of the origin of the structural softening.
Published: 2020

31. Table Recomputation-Based Higher-Order Masking Against Horizontal Attacks

Author: Zhipeng Guo, Ming Tang, Emmanuel Prouff, Maixing Luo, Fei Yan, Wuhan University [China], and Agence nationale de la sécurité des systèmes d'information (ANSSI)
Subjects: Security analysis, Computer science, 02 engineering and technology, Computer Graphics and Computer-Aided Design, Secret sharing, Masking (Electronic Health Record), 020202 computer hardware & architecture, [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR], Lookup table, 0202 electrical engineering, electronic engineering, information engineering, Side channel attack, Electrical and Electronic Engineering, Arithmetic, Software
Abstract: Masking is a class of well-known countermeasure against side-channel analysis by employing the idea of secret sharing. The theoretical security proof model of higher-order masking was initiated by Ishai, Sahai, and Wagner, and Barthe et al. pushed forward it by proposing a more refine security definition named as ${t}$ -SNI security. In CHES 2016, a new attack called horizontal side-channel attacks (HSCAs) came forward and successfully broke the Rivain–Prouff countermeasure, which has been proved to satisfy the ${t}$ -SNI security. It presents a dilemma: instead of more secure, masking with higher-order may be more vulnerable due to the HSCA. Although there already exists an effective countermeasure for the Rivain–Prouff scheme, it is quite difficult to apply this method in the table recomputation-based higher-order masking schemes, such as the scheme introduced by Coron in EUROCRYPT 2014. To fill this gap, we propose a new table recomputation-based higher-order masking scheme, named as table compression masking (TCM) scheme. While meeting the ${t}$ -SNI security, our new countermeasure is also secure against the HSCA. We give the formal security proof under the ${t}$ -SNI security definition, as well as a heuristic security analysis considering the HSCA. Our analysis shows that, by dividing the full lookup table into many distinct parts and shifting them by refreshed shares, the same share will never be manipulated for more than twice in TCM scheme. This feature gives a heuristic security against HSCA. To our best knowledge, our countermeasure is the first solution for table recomputation-based higher-order masking to resist HSCA.
Published: 2020

32. Multi-decadal analysis of high-resolution albedo changes induced by urbanization over contrasted Chinese cities based on Landsat data

Author: Tianci Guo, Tao He, Shunlin Liang, Jean-Louis Roujean, Yuyu Zhou, Xin Huang, Wuhan University [China], Department of Geographical Sciences [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Centre d'études spatiales de la biosphère (CESBIO), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Iowa State University (ISU)
Subjects: Albedo, Urbanization, [SDE]Environmental Sciences, Soil Science, Geology, Computers in Earth Sciences, Remote sensing, Land cover change, Landsat
Abstract: International audience; Surface albedo is a key parameter in the surface energy balance and has been identified as a primary essential climate variable (ECV). Variations in surface albedo can be used as a diagnostic tool for local climate change. This is particularly true in urban areas, where the impacts of land cover conversion due to increasing anthropogenic demands can be examined using surface albedo changes. Most of the previous studies of albedo in cities have relied on coarse-resolution datasets with short time spans and have disregarded continuous monitoring. In addition, it is still unclear which urbanization processes are involved and what effects they have on surface albedo over long time periods. This study aimed to identify the contribution of increasing urbanization to the regional climate by analyzing spatial and temporal changes in surface albedo. Assigning albedo values to land cover types is useful for determining the level of transformation and their impacts in various Chinese cities that underwent specific evolutions between 1986 and 2018. The Direct Estimation (DE) approach was modified to estimate the daily mean surface albedo at 30 m based on Landsat observations. It resulted root-mean-square errors (RMSEs) of less than 0.044 and bias about 0.006 between observations and model estimations. Such accuracy obtained after correcting the orbital drift of the Landsat satellite, was deemed satisfactory for detecting potential changes in albedo. Major findings are: 1) A notable trend was found over the past 33 years of 11 major Chinese cities, i.e. population about 10 million and more, with a general albedo increase from satellite observations. The higher resolution Landsat dataset showed a trend 3 times larger than the Global Land Surface Satellites (GLASS) product, which outlines the need for analyzing high resolution imagery in priority for reliable estimate of albedo over heterogeneous urban landscapes. 2) An increase in albedo infers a negative radiative forcing at an average rate of -2.771 W/m2 per decade, thereby indicating a cooling effect for most Chinese cities. 3) Changes in surface albedo were also closely linked to landscape transformation, clearly observed using the 30 m resolution of the Landsat data. 4) Throughout the study period, surface albedo exhibited a temporal U-shaped curve in built-up areas under development, with albedo peaks in old and newly built districts and a decrease in albedo between the two eras.
Published: 2022

33. Three Gorges Dam: friend or foe of riverine greenhouse gases?

Author: Jinren Ni, Haizhen Wang, Tao Ma, Rong Huang, Philippe Ciais, Zhe Li, Yao Yue, Jinfeng Chen, Bin Li, Yuchun Wang, Maosheng Zheng, Ting Wang, Alistair G L Borthwick, College of Environmental Sciences and Engineering [Peking], Peking University [Beijing], Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences [Beijing] (CAS), Wuhan University [China], China Institute of Water Resources and Hydropower Research (IWHR), North China Electric Power University, University of Edinburgh, and This work was supported by the National Natural Science Foundation of China (51721006, 92047303, and U2240205)
Subjects: Yangtze River, Multidisciplinary, whole system analysis, Equilibrium, greenhouse gas, [CHIM]Chemical Sciences, equilibrium, spatiotemporal variation, Three Gorges Dam
Abstract: Dams are often regarded as greenhouse gas (GHG) emitters. However, our study indicated that the world's largest dam, the Three Gorges Dam (TGD), has caused significant drops in annual average emissions of CO2, CH4 and N2O over 4300 km along the Yangtze River, accompanied by remarkable reductions in the annual export of CO2 (79%), CH4 (50%) and N2O (9%) to the sea. Since the commencement of its operation in 2003, the TGD has altered the carbonate equilibrium in the reservoir area, enhanced methanogenesis in the upstream, and restrained methanogenesis and denitrification via modifying anoxic habitats through long-distance scouring in the downstream. These findings suggest that ‘large-dam effects’ are far beyond our previous understanding spatiotemporally, which highlights the fundamental importance of whole-system budgeting of GHGs under the profound impacts of huge dams.
Published: 2022

34. Truncated Series with Nonnegative Coefficients from the Jacobi Triple Product

Author: Wang, Liuquan, Department of Mathematics [Wuhan], and Huazhong University of Science and Technology [Wuhan] (HUST)-Wuhan University [China]
Subjects: Euler's pentagonal number theorem, Mathematics - Number Theory, nonnegative coefficients, Partitions, Jacobi triple product, FOS: Mathematics, Mathematics - Combinatorics, 2010 Mathematics Subject Classification. Primary 11P81, 05A17, Combinatorics (math.CO), Number Theory (math.NT), [MATH]Mathematics [math], truncated series, Primary 11P81, secondary 05A17
Abstract: Andrews and Merca investigated a truncated version of Euler's pentagonal number theorem and showed that the coefficients of the truncated series are nonnegative. They also considered the truncated series arising from Jacobi's triple product identity, and they that its coefficients are nonnegative. This conjecture was posed by Guo and Zeng independently and confirmed by Mao and Yee using different approaches. In this paper, we provide a new combinatorial proof of their nonnegativity result related to Euler's pentagonal number theorem. Meanwhile, we find an analogous result for a truncated series arising from Jacobi's triple product identity in a different manner., Comment: 11 pages
Published: 2022

35. The industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1

Author: Xiaoyi Mo, Qiang Liu, Luna Gao, Chang Xie, Xin Wei, Peiyuan Pang, Quan Tian, Yue Gao, Youjing Zhang, Yuanyuan Wang, Tianchen Xiong, Bo Zhong, Dongdong Li, Jing Yao, Wuhan University [China], School of Pubic Health, Wuhan University of Science and Technology, Institut de Biologie Paris Seine (IBPS), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nociception, Physiology, QH301-705.5, Inflammatory pain, Hyperalgesia 1, TRPV Cation Channels, Plant Science, 1,4-Dioxane, General Biochemistry, Genetics and Molecular Biology, Dioxanes, 03 medical and health sciences, Mice, 0302 clinical medicine, Structural Biology, Animals, Biology (General), Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 4-Dioxane, 0303 health sciences, Cell Biology, TRPV1, Hyperalgesia, Solvents, [SDV.IMM]Life Sciences [q-bio]/Immunology, Capsaicin, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery, Developmental Biology, Biotechnology, Research Article
Abstract: Background The synthetic chemical 1,4-dioxane is used as industrial solvent, food, and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments and in humans, but the molecular mechanisms underlying its effects on animals were not previously known. Results Here, we report that 1,4-dioxane potentiates the capsaicin-sensitive transient receptor potential (TRP) channel TRPV1, thereby causing hyperalgesia in mouse model. This effect was abolished by CRISPR/Cas9-mediated genetic deletion of TRPV1 in sensory neurons, but enhanced under inflammatory conditions. 1,4-Dioxane lowered the temperature threshold for TRPV1 thermal activation and potentiated the channel sensitivity to agonistic stimuli. 1,3-dioxane and tetrahydrofuran which are structurally related to 1,4-dioxane also potentiated TRPV1 activation. The residue M572 in the S4-S5 linker region of TRPV1 was found to be crucial for direct activation of the channel by 1,4-dioxane and its analogs. A single residue mutation M572V abrogated the 1,4-dioxane-evoked currents while largely preserving the capsaicin responses. Our results further demonstrate that this residue exerts a gating effect through hydrophobic interactions and support the existence of discrete domains for multimodal gating of TRPV1 channel. Conclusions Our results suggest TRPV1 is a co-receptor for 1,4-dioxane and that this accounts for its ability to dysregulate body nociceptive sensation.
Published: 2022

36. ALMA-IMF

Author: Motte, F., Bontemps, S., Csengeri, T., Pouteau, Y., Louvet, F., Stutz, A. M., Cunningham, N., López-Sepulcre, A., Brouillet, N., Galván-Madrid, R., Ginsburg, A., Maud, L., Men’shchikov, A., Nakamura, F., Nony, T., Sanhueza, P., Álvarez-Gutiérrez, R. H., Armante, M., Baug, T., Bonfand, M., Busquet, G., Chapillon, E., Díaz-González, D., Fernández-López, M., Guzmán, A. E., Herpin, F., Liu, H.-L., Olguin, F., Towner, A. P. M., Bally, J., Battersby, C., Braine, J., Bronfman, L., Chen, H.-R. V., Dell’ova, P., Di Francesco, J., González, M., Gusdorf, A., Hennebelle, P., Izumi, N., Joncour, I., Lee, Y.-N., Lefloch, B., Lesaffre, P., Lu, X., Menten, K. M., Mignon-Risse, R., Molet, J., Moraux, E., Mundy, L., Nguyen Luong, Q., Reyes, N., Reyes Reyes, S. D., Robitaille, J.-F., Rosolowsky, E., Sandoval-Garrido, N. A., Schuller, F., Svoboda, B., Tatematsu, K., Thomasson, B., Walker, D., Wu, B., Whitworth, A. P., Wyrowski, F., Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), FEMIS 2021, Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Universitat de València (UV), Wuhan University [China], Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Fudan University [Shanghai], ANR-16-CE92-0035,GENESIS,GENeration et Evolution des Structures du milieu InterStellaire(2016), and ANR-20-CE31-0009,COSMHIC,L'origine de la masse des étoiles dans des nuages hiérarchiques en effondrement(2020)
Subjects: stars: formation, stars: protostars, stars: luminosity function, mass function, evolution, H II regions, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], ISM: clouds
Abstract: International audience; Aims. Thanks to the high angular resolution, sensitivity, image fidelity, and frequency coverage of ALMA, we aim to improve our understanding of star formation. One of the breakthroughs expected from ALMA, which is the basis of our Cycle 5 ALMA-IMF Large Program, is the question of the origin of the initial mass function (IMF) of stars. Here we present the ALMA-IMF protocluster selection, first results, and scientific prospects.Methods. ALMA-IMF imaged a total noncontiguous area of ~53 pc2, covering extreme, nearby protoclusters of the Milky Way. We observed 15 massive (2.5 −33 × 103 M⊙), nearby (2−5.5 kpc) protoclusters that were selected to span relevant early protocluster evolutionary stages. Our 1.3 and 3 mm observations provide continuum images that are homogeneously sensitive to point-like cores with masses of ~0.2 M⊙ and ~0.6 M⊙, respectively, with a matched spatial resolution of ~2000 au across the sample at both wavelengths. Moreover, with the broad spectral coverage provided by ALMA, we detect lines that probe the ionized and molecular gas, as well as complex molecules. Taken together, these data probe the protocluster structure, kinematics, chemistry, and feedback over scales from clouds to filaments to cores.Results. We classify ALMA-IMF protoclusters as Young (six protoclusters), Intermediate (five protoclusters), or Evolved (four proto-clusters) based on the amount of dense gas in the cloud that has potentially been impacted by H II region(s). The ALMA-IMF catalog contains ~700 cores that span a mass range of ~0.15 M⊙ to ~250 M⊙ at a typical size of ~2100 au. We show that this core sample has no significant distance bias and can be used to build core mass functions (CMFs) at similar physical scales. Significant gas motions, which we highlight here in the G353.41 region, are traced down to core scales and can be used to look for inflowing gas streamers and to quantify the impact of the possible associated core mass growth on the shape of the CMF with time. Our first analysis does not reveal any significant evolution of the matter concentration from clouds to cores (i.e., from 1 pc to 0.01 pc scales) or from the youngest to more evolved protoclusters, indicating that cloud dynamical evolution and stellar feedback have for the moment only had a slight effect on the structure of high-density gas in our sample. Furthermore, the first-look analysis of the line richness toward bright cores indicates that the survey encompasses several tens of hot cores, of which we highlight the most massive in the G351.77 cloud. Their homogeneous characterization can be used to constrain the emerging molecular complexity in protostars of high to intermediate masses.Conclusions. The ALMA-IMF Large Program is uniquely designed to transform our understanding of the IMF origin, taking the effects of cloud characteristics and evolution into account. It will provide the community with an unprecedented database with a high legacy value for protocluster clouds, filaments, cores, hot cores, outflows, inflows, and stellar clusters studies.
Published: 2022

37. Hypersensitivity of the Glass Transition to Pressure History in a Metal-Organic Framework Glass

Author: Ang Qiao, Søren S. Sørensen, Malwina Stepniewska, Christophe A. N. Biscio, Lisbeth Fajstrup, Zhu Wang, Xianghua Zhang, Laurent Calvez, Ivan Hung, Zhehong Gan, Morten M. Smedskjaer, Yuanzheng Yue, Aalborg University [Denmark] (AAU), Wuhan University of Technology (WHUT), Wuhan University [China], Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), National High Magnetic Field Laboratory (NHMFL), Florida State University [Tallahassee] (FSU), VILLUM FONDEN [13253], National Natural Science Foundation of China [22175135, 11975169, U2067207], and Fundamental Research Funds for the Central Universities [WUT: 2021IVA099, 2021III018JC, 2021IVB058]
Subjects: General Chemical Engineering, Materials Chemistry, [CHIM]Chemical Sciences, General Chemistry
Abstract: International audience; Metal-organic framework (MOF) glasses feature numerous unique properties and potential applications, but many fundamental questions remain unanswered, especially concerning their glass transition. Here, we report a discovery about ZIF-62 glass (a typical MOF glass), namely, the hypersensitivity of its glass transition to pressure history. Specifically, upon quenching the ZIF-62 melt under a modest pressure of 60 MPa, the derived glass exhibited a significantly lower glass transition temperature (T-g) than the glass formed under ambient pressure. The sensitivity parameter of T-g to pressure for ZIF-62 glass is much higher than that of other glass systems, including polymer glasses that typically feature a huge increase in T-g upon compression. The origin of the hypersensitivity of T-g to pressure history was revealed by structural analyses, positron annihilation lifetime spectroscopy, and molecular dynamics simulations. We found that the medium-range structure change induced the drop in T-g.
Published: 2022

38. Spiking Sparse Recovery with Non-convex Penalties

Author: Xiang Zhang, Gang Zheng, Yonina Eldar, Lei Yu, Wuhan University [China], Deformable Robots Simulation Team (DEFROST ), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Weizmann Institute of Science [Rehovot, Israël], and Zheng, Gang
Subjects: Sparse recovery, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, nonconvex optimization, Signal Processing, Sparse recovery spiking neural network nonconvex optimization, Electrical and Electronic Engineering, spiking neural network
Abstract: International audience; Sparse recovery (SR) based on spiking neural networks has been shown to be computationally efficient with ultra-low power consumption. However, existing spiking-based sparse recovery (SSR) algorithms are designed for the convex 1-norm regularized SR problem, which often underestimates the true solution. This paper proposes an adaptive version of SSR, i.e., A-SSR, to optimize a class of non-convex regularized SR problems and analyze its global asymptotic convergence. The superiority of A-SSR is validated with synthetic simulations and real applications, including image reconstruction and face recognition. Furthermore, it is shown that the proposed A-SSR essentially improves the recovery accuracy by avoiding systematic underestimation and obtains over 4 dB PSNR improvement in image reconstruction quality and around 5% improvement in recognition confidence. At the same time, the proposed A-SSR maintains energy efficiency in hardware implementation. When implemented on the neuromorphic Loihi chip, our method consumes only about 1% of the power of the iterative solver FISTA, enabling applications under energy-constrained scenarios.
Published: 2022

39. Incremental shear strain chain: a mesoscale concept for slip lines in 2D granular materials

Author: Jiaying Liu, Antoine Wautier, Wei Zhou, François Nicot, Félix Darve, Zhejiang University City College, Zhejiang Engineering Research Center of Intelligent Urban Infrastructure, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Wuhan University [China], Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and National Natural Science Foundation of China under Grant No.51909194 Zhejiang Provincial Natural Science Foundation of China under Grant No. LY22E090002.
Subjects: granular plasticity, Mechanics of Materials, granular materials, [SPI.GCIV.GEOTECH]Engineering Sciences [physics]/Civil Engineering/Géotechnique, DEM, General Physics and Astronomy, incremental shear strain chain, General Materials Science, slip line, ZABR, [SPI.MECA.SOLID]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Solid mechanics [physics.class-ph], mesostructures
Abstract: International audience; Constitutive behaviors of granular materials are driven by both particle interactions and geometric arrangements of contact network. To bridge the gap between the grain scale and the sample scale, the mesoscale is of great importance as it corresponds to the smallest scale at which geometrical effect can be accounted for. Meso shear structures (sometimes called microbands) have been observed frequently on incremental strain maps Shear chain concept for granular materials in granular materials under shearing, while the Rudnicki and Rice localization criterion for shear band is not fulfilled yet. These meso structures are thin, quasi-linear and they involve a few grains as well as their surrounding voids. This paper introduces the concept of "incremental shear strain chain" (simply called "shear chain") to provide a specific quantitative definition of such mesostructures. "Shear chains" are defined based on incremental deviatoric strain fields in 2D biaxial simulations. Particular attention is paid to demonstrate that the shear chain orientation is a material scale property, insensitive to boundary conditions, loading paths and sample densities. Since shear chains are shown to be closely related to sliding mechanisms, they can stand for a mesoscale definition of the concept of slip lines as defined in the standard elasto-plasticity theory.
Published: 2022

40. Les premières industries lithiques d’Asie du Sud-Est continentale : évidence des premiers hominines en contexte tropical

Author: Hubert Forestier, Yuduan Zhou, Heng Sophady, Yinghua Li, David Codeluppi, Prasit Auetrakulvit, Valéry Zeitoun, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Wuhan University [China], Royal University of Phnom Penh (RUPP), Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène (AnTET), Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), Silpakorn University [Bangkok, Thaïlande], Centre de Recherche en Paléontologie - Paris (CR2P), and Muséum national d'Histoire naturelle (MNHN)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Pebble tool, Asie du Sud-Est continentale, Mainland Southeast Asia, Middle Pleistocene, Assemblage lithique, History and Philosophy of Science, Handaxe, Outil sur galet, Biface, Anthropology, Pléistocène moyen, Lithic assemblage, [SHS]Humanities and Social Sciences
Abstract: International audience; Recent discoveries of ancient sites in mainland Southeast Asia confirm the presence of old lithic industries as early as 0.8 Ma, i.e., at the transition between the Early to Middle Pleistocene. Although these open-air sites still require geochronological and biostratigraphic precisions, they allow us to understand the oldest vestiges of human presence in the tropics and the technical orientations chosen by these hominins. This article aims to present an objective and critical synthesis of the material discovered at the main sites. Some sites in Cambodia and Thailand have been the subject of archaeological field missions by the Ministère de l’Europe et des Affaires Étrangères (MEAE). The diversity of lithic tool types and manufacture methods encountered from the Middle Pleistocene in peninsular Asia shows a technical variability that stands out as a counterexample to diffusionist hypotheses of a cultural fabrication inherited from the West. The diversity of production methods, tools, and raw material matrices remains incomparable to those encountered in the West, Africa, or South Asia. To date, only evidence from China has allowed us to put forward the hypothesis of a common technical basis that would have spread from its southern territories; however, this hypothesis is currently under debate. Researchers have proposed the idea of continuous technical progress and the shift from heavy industry to a lighter and polished stone in Southeast Asia. However, the omnipresence of the pebble prevents a clear conclusion because these technical objects from Southeast Asia are quite simply incommensurable; a chopper in these regions may not be comparable with another chopper from the terraces of the Garonne or the Roussillon in France, for example. In other words, these tools are above all ‘tropical’ tools, and they belong to a distant cognitive world(s) with specific use(s), gesture(s), and meaning(s), making it impossible for them to be compared or evaluated by our faculty of Western judgment.; Les récentes découvertes de sites anciens en Asie du Sud-Est continentale confirment de la présence de vieilles industries dès 0,8 Ma, c’est-à-dire à la transition entre le Pléistocène ancien et moyen. Même si ces sites de plein air nécessitent encore des précisions géochronologiques et biostratigraphiques, ils permettent d’appréhender les plus anciens vestiges de la présence humaine sous les tropiques et les orientations techniques choisies par les hominines. D’un point de vue typo-technique, un ensemble de critères confirme l’hypothèse anthropique de ces objets qui affichent une variabilité étonnante pour une période aussi reculée du Quaternaire dans une Asie tropicale encore à découvrir. Cet article a pour objectif de présenter une synthèse objective et critique du matériel découvert sur les principaux sites dont certains au Cambodge et en Thaïlande ont fait l’objet de missions de terrain archéologiques du MEAE. La diversité des différents types d’outils lithiques et des modes de fabrication rencontrés dès le Pléistocène moyen en Asie péninsulaire, montrent très tôt une variabilité technique qui s’impose à la fois comme un commencement et comme un contre-exemple à toute explication diffusionniste d’une nappe culturelle héritée de l’Ouest. La diversité des modes de production et des outillages mais aussi des matrices des matières premières, restent incomparables à celles rencontrées en Occident, Afrique ou en Asie du Sud. Seule la Chine permet à ce jour d’avancer l’hypothèse d’un fond technique commun qui se serait répandu depuis ses territoires méridionaux et encore, rien n’est absolument certain. Est-il possible, au fond, de parler de progrès techniques continus et de passage d’industrie lourde à plus légère puis à la pierre polie en Asie du Sud-Est ? L’omniprésence du galet nous empêche de répondre en nous rappelant que ces objets techniques rencontrés en Asie du Sud-Est sont tout simplement incommensurables, autant que peut l’être un chopper dans ces régions avec un autre trouvé des terrasses de la Garonne ou du Roussillon en France. Autrement dit, ces outils sont des outils avant tout « tropicaux» et ils appartiennent à des mondes cognitif(s), d’usage(s), de geste(s), de sens trop éloignés pour qu’ils puissent être comparés ou évalués par notre faculté de juger occidentale.
Published: 2022

41. Mesoscale investigation of fine grain contribution to contact stress in granular materials

Author: Qirui Ma, Antoine Wautier, François Nicot, Wautier, Antoine, Wuhan University [China], Aix Marseille Université (AMU), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Grenoble Alpes (UGA), and This work was financially supported by the China Scholarship Council (No. 201906270111). This enabled Qirui Ma to spend one year as a visiting Ph.D. Candidate at INRAE under the supervision of Dr. A. Wautier. Revision work was done while Qirui Ma was financially supported by the Key research and development plan of Hubei Province, China (No. 2020BCA083).
Subjects: Mechanical Engineering, [SPI.GCIV.GEOTECH]Engineering Sciences [physics]/Civil Engineering/Géotechnique, [PHYS.PHYS.PHYS-COMP-PH] Physics [physics]/Physics [physics]/Computational Physics [physics.comp-ph], DEM, [SPI.MECA.SOLID]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Solid mechanics [physics.class-ph], Fine grains, [PHYS.PHYS.PHYS-COMP-PH]Physics [physics]/Physics [physics]/Computational Physics [physics.comp-ph], contact stress, Mesoscopic scale, Mechanics of Materials, [SPI.GCIV.GEOTECH] Engineering Sciences [physics]/Civil Engineering/Géotechnique, [SPI.MECA.SOLID] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Solid mechanics [physics.class-ph], jamming, Granular material, Multiscale approach
Abstract: International audience; Fine grains play an important role in mechanical properties of granular materials as they control how plastic strain may develop, which has a noticeable impact on mechanical stability. In this work, we use numerical simulations based on a discrete element method (DEM) to analyze the stress contribution of fine grains to the total stress. Different from usual DEM simulations, the analysis is conducted directly at the mesoscopic scale by considering an idealized grain assembly. The results show how fine grains get progressively jammed and increasingly participate to stress transmission. Fine contribution to contact stress is shown to be non-isotropic. The principal anisotropy direction coincides with the principal direction of contraction and the anisotropy ratio (i.e. the ratio between the largest and the smallest eigenvalues of the fine stress) is shown to be limited (⁄ ≃ 2). By performing strain controlled directional analyses, an analytical model is proposed to account for the stress contribution of fine grains along various loading paths. Its simple form will help to enrich advanced micro-mechanically-based constitutive formulations, and better account for the constitutive behavior of widely graded granular materials.
Published: 2022

42. Podocytes maintain high basal levels of autophagy independent of mtor signaling

Author: Bjoern Hartleben, Wei Liang, Shuya Liu, Kosuke Yamahara, Ketan Patel, Kathrin Thedieck, Tillmann Bork, Olivia Lenoir, Philipp Lee, Christoph Schell, Tobias B. Huber, Zhejia Tian, Pierre-Louise Tharaux, Department of Medicine IV [Freiburg, Germany] (Faculty of Medicine), University of Freiburg [Freiburg], Division of Nephrology [Wuhan, China], Wuhan University [China]-Renmin Hospital [Wuhan, China], Department of Medicine [Otsu, Japan], Shiga University of Medical Science, Department of Medicine [Hamburg, Germany], Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Center for Molecular Biosciences Innsbruck [Innsbruck, Austria] (Institute of Biochemistry), University of Innsbruck, University Medical Center Groningen [Groningen] (UMCG), University of Oldenburg, Hannover Medical School [Hannover] (MHH), Freiburg Institute for Advanced Studies [Freiburg, Germany], Albert-Ludwigs-Universität Freiburg, School of Biological Sciences [Reading], University of Reading (UOR), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de néphrologie [Hôpital Européen Georges Pompidou - APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), This work was supported by the German Research Foundation [CRC1140, CRC1192], European Foundation for the Study of Diabetes (EFSD), German Research Foundation Heisenberg Program [HU1016/ 5-1], German Research Foundation Heisenberg Program [HU1016/8-2], EC | European Research Council (ERC), H2020-IMI2 BEAt-DKD [115974], BMBF-STOP-FSGS [01GM1518C], Excellence Initiative of the German Federal and State Governments BIOSS, FRIAS Freiburg Institute of Advanced Studies, Alexander von Humboldt Foundation, German Research Foundation [CRC992], National Natural Science Foundation of China (NSFC) [81470912], Berta Ottenstein Program, Else Kroener Fresenius Foundation NAKSYS, BMBF GlioPATH [01ZX1402B], BMBF MAPTor-NET [031A426B], German Research Foundation [TH 1358/3-1], MESI-STRAT [754688], Uehara Memorial Foundation, German TS Foundation, Stichting TSC Fonds (calls 2015 and 2017), PoLiMeR Innovative Training Network (Marie SklodowskaCurie grant agreement No. 812616, Rosalind-Franklin Fellowship of the Universitiy of Groningen., Tharaux, Pierre-Louis, Leopold Franzens Universität Innsbruck - University of Innsbruck, and Center for Liver, Digestive and Metabolic Diseases (CLDM)
Subjects: AMPK, 0301 basic medicine, podocyte, Research Paper - Basic Science, PROTEIN, glomerulus, Podocyte, ACTIVATION, LC3, PHOSPHORYLATION, ULK1, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, CELL-LINE, biology, Podocytes, TOR Serine-Threonine Kinases, MTOR, Raptor, Cell biology, medicine.anatomical_structure, signaling, Signal Transduction, Research Article, autophagy, kidney, Mice, Transgenic, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Mechanistic Target of Rapamycin Complex 1, DIABETIC-NEPHROPATHY, Nephrin, 03 medical and health sciences, medicine, Animals, Humans, Protein kinase A, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Molecular Biology, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Sirolimus, 030102 biochemistry & molecular biology, rapamycin, RPTOR, Autophagy, KIDNEY-DISEASE, Cell Biology, Tsc1, 030104 developmental biology, MAMMALIAN TARGET, biology.protein, Podocin, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve long-lived podocytes at the filtration barrier, MTOR regulates at the same time podocyte size and compensatory hypertrophy. Since MTOR is known to generally suppress autophagy, the apparently independent regulation of these two key pathways of glomerular maintenance remained puzzling. We now report that long-term genetic manipulation of MTOR activity does in fact not influence high basal levels of autophagy in podocytes either in vitro or in vivo. Instead we present data showing that autophagy in podocytes is mainly controlled by AMP-activated protein kinase (AMPK) and ULK1 (unc-51 like kinase 1). Pharmacological inhibition of MTOR further shows that the uncoupling of MTOR activity and autophagy is time dependent. Together, our data reveal a novel and unexpected cell-specific mechanism, which permits concurrent MTOR activity as well as high basal autophagy rates in podocytes. Thus, these data indicate manipulation of the AMPK-ULK1 axis rather than inhibition of MTOR as a promising therapeutic intervention to enhance autophagy and preserve podocyte homeostasis in glomerular diseases.Abbreviations: AICAR: 5-aminoimidazole-4-carboxamide ribonucleotide; AMPK: AMP-activated protein kinase; ATG: autophagy related; BW: body weight; Cq: chloroquine; ER: endoplasmic reticulum; ESRD: end stage renal disease; FACS: fluorescence activated cell sorting; GFP: green fluorescent protein; i.p.: intra peritoneal; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; NPHS1: nephrosis 1, nephrin; NPHS2: nephrosis 2, podocin; PLA: proximity-ligation assay; PRKAA: 5'-AMP-activated protein kinase catalytic subunit alpha; RPTOR/RAPTOR: regulatory associated protein of MTOR, complex 1; RFP: red fluorescent protein; TSC1: tuberous sclerosis 1; ULK1: unc-51 like kinase 1.
Published: 2019

43. The first global soil moisture and vegetation optical depth product retrieved from fused SMOS and SMAP L-band observations

Author: Xiaojun Li, Jean-Pierre Wigneron, Frédéric Frappart, Gabrielle De Lannoy, Lei Fan, Tianjie Zhao, Lun Gao, Shengli Tao, Hongliang Ma, Zhiqing Peng, Xiangzhuo Liu, Huan Wang, Mengjia Wang, Christophe Moisy, Philippe Ciais, Interactions Sol Plante Atmosphère (UMR ISPA), Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Earth and Environmental Sciences [Leuven] (EES), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Southwest University [Chongqing], Chinese Academy of Sciences [Beijing] (CAS), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Peking University [Beijing], Wuhan University [China], Beijing Normal University (BNU), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, SMAP-IBL-band, Soil Science, Vegetation optical depth, Geology, SMAP, Soil moisture, Computers in Earth Sciences, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Merging, SMOS
Abstract: International audience; ESA's Soil Moisture Ocean Salinity (SMOS, since 2009) and NASA's Soil Moisture Active Passive (SMAP, since 2015) are the only two space-borne L-band radiometer missions currently in orbit, which provide key information on global surface soil moisture (SM) and vegetation water content (via the vegetation optical depth, VOD). However, to date very few studies considered merging SMOS and SMAP for both SM and VOD retrievals simultaneously. This study presents the first global long-term and continuous SM and L-band VOD (L-VOD) dataset retrieved after merging the SMOS and SMAP brightness temperature (TB) observations, called the SMOS-SMAP-INRAE-BORDEAUX or SMOSMAP-IB product. We first developed a fitted SMOS TB dataset at a fixed incidence angle of 40°, and next applied a monthly linear rescaling of SMAP TB to SMOS TB for each polarization to produce a merged SMOS/SMAP TB (θ = 40°) dataset. The retrievals were then based on a mono-angular retrieval algorithm sharing a similar forward model with the SMOS-IC and the official SMOS retrieval algorithms. Results showed that the inter-calibration approach we used here could effectively remove the bias between the SMAP TB and fitted SMOS TB, with bias values reduced to 0.01 K (−0.02 K) compared to 3.45 K (1.65 K) for V (H) polarization before inter-calibration. The SMOSMAP-IB SM and L-VOD retrievals based on this new inter-calibrated SMOS/SMAP TB led to metrics that were equally good or better than those of other products (i.e., ESA CCI, SMOS-IC and the official SMAP products). When considering only long duration products, SMOSMAP-IB SM retrievals exhibited (i) the highest overall median R value of 0.72 with in-situ data from ISMN (International Soil Moisture Network) during 2013–2018, followed by SMOS-IC (R = 0.68) and CCI (R = 0.67), and (ii) the same smallest ubRMSD values as CCI (ubRMSD = 0.057 m3/m3 vs 0.061 m3/m3 for SMOS-IC). L-VOD retrievals from SMOSMAP-IB were found to have comparable spatial and temporal skills to SMOS-IC. Spatially, they both correlated well with aboveground biomass (R = 0.87), and temporally, they both showed a good representation of the short vegetation NDVI signal and of the forest area loss in the Brazilian Amazon from 2011 to 2019. Developing SMOSMAP-IB is a step forward towards building a time-continuous L-band SM and VOD products in response to the possible failure of one of the SMOS or SMAP sensors in the future.
Published: 2022

44. Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: Update of taxonomy changes in 2021

Author: Krupovic, Mart, Turner, Dann, Morozova, Vera, Dyall-Smith, Mike, Oksanen, Hanna M., Edwards, Rob, Dutilh, Bas E., Lehman, Susan M., Reyes, Alejandro, Baquero, Diana P., Sullivan, Matthew B., Uchiyama, Jumpei, Nakavuma, Jesca, Barylski, Jakub, Young, Mark J., Du, Shishen, Alfenas-Zerbini, Poliane, Kushkina, Alla, Kropinski, Andrew M., Kurtboke, Ipek, Brister, J. Rodney, Lood, Cedric, Sarkar, B. L., Yigang, Tong, Liu, Ying, Huang, Li, Wittmann, Johannes, Chanishvili, Nina, van Zyl, Leonardo J., Rumnieks, Janis, Mochizuki, Tomohiro, Jalasvuori, Matti, Aziz, Ramy K., Lobocka, Malgorzata, Stedman, Kenneth M., Shkoporov, Andrey N., Gillis, Annika, Peng, Xu, Enault, Francois, Knezevic, Petar, Lavigne, Rob, Rhee, Sung-Keun, Cvirkaite-Krupovic, Virginija, Moraru, Cristina, Moreno Switt, Andrea I., Poranen, Minna M., Millard, Andrew, Prangishvili, David, Adriaenssens, Evelien M., Sub Bioinformatics, Theoretical Biology and Bioinformatics, UCL - SST/ELI/ELIM - Applied Microbiology, Sub Bioinformatics, Theoretical Biology and Bioinformatics, Virologie des archées - Archaeal Virology, Institut Pasteur [Paris], University of the West of England [Bristol] (UWE Bristol), Institute of Chemical Biology and Fundamental Medicine [Novosibirsk, Russia] (ICBFM SB RAS), Siberian Branch of the Russian Academy of Sciences (SB RAS), University of Melbourne, University of Helsinki, Flinders Accelerator for Microbiome Exploration [Adelaide, Australia], Utrecht University [Utrecht], U.S. Food and Drug Administration (FDA), Universidad de los Andes [Bogota] (UNIANDES), Ohio State University [Columbus] (OSU), Azabu University, Makerere University [Kampala, Ouganda] (MAK), Adam Mickiewicz University in Poznań (UAM), Montana State University (MSU), Wuhan University [China], Universidade Federal de Vicosa (UFV), National Academy of Sciences of Ukraine (NASU), University of Guelph, University of the Sunshine Coast (USC), National Institutes of Health [Bethesda] (NIH), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Indian Council of Medical Research [New Dehli] (ICMR), Beijing University of Chemical Technology, Chinese Academy of Sciences [Beijing] (CAS), Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH / Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (DSMZ), George Eliava Institute of Bacteriophages, Microbiology and Virology [Tbilisi, Georgia], University of the Western Cape, Latvian Biomedical Research and Study Centre [Rīga], Tokyo Institute of Technology [Tokyo] (TITECH), University of Jyväskylä (JYU), Cairo University, Polish Academy of Sciences (PAN), Portland State University [Portland] (PSU), University College Cork (UCC), Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Copenhagen = Københavns Universitet (KU), Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of Novi Sad, Chungbuk National University, University of Oldenburg, Pontificia Universidad Católica de Chile (UC), University of Leicester, Ivane Javakhishvili Tbilisi State University (TSU), Quadram Institute, V.M. was supported by Russian Ministry of Education and Science Project No. 0245-2021-0008, H.M.O. was supported by University of Helsinki funding for FINStruct and Instruct-ERIC research infrastructure, R.A.E. was supported by the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under Award Number RC2DK116713, B.E.D. was supported by the European Research Council (ERC) Consolidator grant 865694: DiversiPHI, M.B.S. was supported by National Science Foundation Advances in Biological Infrastructure award #1758974, M.Y. acknowledges funding by the Gordon and Betty Moore Foundation grant GBMF9195, S.D. was supported by National Natural Science Foundation of of China grant 32070032, C.L. is supported by the Fonds Wetenschappelijk Onderzoek (1S64718N), L.H. was funded by the Strategic Priority Research Program of the Chinese Academy of Sciences Award XDB42000000,National Natural Science Foundation of China (NSFC) grant 31970170, T.M. was supported by JSPS KAKENHI Grant Numbers 21H02100, 19H04827, 18K14372, and JST JPMJJR2005, and SUMITOMO Fund 200673, MJ is supported by Academy of Finland grants #336518 and #297049 and Jane and Aatos Erkko Foundation, R.K.A. is supported by the Egyptian Academy of Scientific Research and Technology (ASRT) project #3046 (JESOR), M.L. is supported by the statutory funds for the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences, K.M.S. is supported by the US. National Science Foundation (MCB1929273 and MCB2025305), A.N.S. is supported by Wellcome Trust Research Career Development Fellowship (220646/Z/20/Z) and by European Research Council (ERC) grant under the European Union’s Horizon 2020 research and innovation programme (grant agreement 101001684), X.P. is supported by Novo Nordisk Foundation/Hallas-Møller Ascending Investigator Grant (grant number NNF17OC0031154) and the Danish Council for Independent Research/FNU (grant number DFF–0135-00402), S.K.R. was supported by the National Research Foundation of Korea (NRF) grants funded by the Ministry of Science, ICT & Future Planning (2021R1A2C3004015), C.M. acknowledges funding by the Deutsche Forschungsgemeinschaft within the Collaborative Research Center TRR51 Roseobacter (INST 184/170-1), M.M.P. acknowledges funding from the Academy of Finland (grant 331627) and the Sigrid Juselius Foundation, E.M.A. gratefully acknowledges funding by the Biotechnology and Biological Sciences Research Council (BBSRC), this research was funded by the BBSRC Institute Strategic Programme Gut Microbes and Health BB/R012490/1 and its constituent projects BBS/E/F/000PR10353 and BBS/E/F/000PR10356., European Project: 865694,H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),DiversiPHI(2020), European Project: 101001684,ERC-2020-COG,PHAGENET(2021), Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Universidade Federal de Viçosa = Federal University of Viçosa (UFV), University of the Western Cape (UWC), University of Copenhagen = Københavns Universitet (UCPH), Biotechnology and Biological Sciences Research Council (BBSRC), Molecular and Integrative Biosciences Research Programme, and Molecular and Translational Virology
Subjects: Archaeal Viruses, Societies, Scientific, virukset, Library science, Biology, bakteriofagit, Executive committee, 03 medical and health sciences, Virology Division News, Virology, viruses, Bacteriophages, 030304 developmental biology, Taxonomy, 11832 Microbiology and virology, 0303 health sciences, Science & Technology, Bacteria, 030306 microbiology, systematiikka (biologia), General Medicine, Archaea, virologia, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Taxonomy (biology), Bacterial virus, Life Sciences & Biomedicine
Abstract: In this article, we – the Bacterial Viruses Subcommittee and the Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) – summarise the results of our activities for the period March 2020 – March 2021. We report the division of the former Bacterial and Archaeal Viruses Subcommittee in two separate Subcommittees, welcome new members, a new Subcommittee Chair and Vice Chair, and give an overview of the new taxa that were proposed in 2020, approved by the Executive Committee and ratified by vote in 2021. In particular, a new realm, three orders, 15 families, 31 subfamilies, 734 genera and 1845 species were newly created or redefined (moved/promoted). Supplementary Information The online version contains supplementary material available at 10.1007/s00705-021-05205-9.
Published: 2021

45. Determination of solid-phase reaction mechanism and chlorine migration behavior of co-pyrolyzing PVC CaCO3 based polymer using temperature-dependent FTIR and XRD analysis

Author: Yanyan Zou, Yaoqiang Li, Jiaqing Zhang, Jiayidaer Baolati, Yi Guo, Kaiyuan Li, Xuanze He, Serge Bourbigot, Université de Lille, CNRS, INRA, ENSCL, Wuhan University [China], Unité Matériaux et Transformations (UMET) - UMR 8207, Unité Matériaux et Transformations - UMR 8207 (UMET), and Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Materials science, Polymers and Plastics, chemistry.chemical_element, Crystal structure, X-ray photoelectron spectroscopy, Materials Chemistry, Dehydrohalogenation, Chlorine, Solid phase reaction, Fourier transform infrared spectroscopy, chemistry.chemical_classification, Olefin fiber, PVC-CaCO3 based polymer, Polymer, [CHIM.MATE]Chemical Sciences/Material chemistry, Condensed Matter Physics, Co-pyrolysis, Residue, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, Chemical engineering, Mechanics of Materials, Outer sheath, Pyrolysis
Abstract: International audience; This paper investigates the pyrolysis of outer sheath polymer of a PVC[sbnd]CaCO3 based cable. TG-DSC-MS, temperature-dependent FTIR, XRD and XPS experiments were conducted to study the pyrolysis characteristics and chlorine migration law for solid products. The results show that the pyrolysis can be divided into three stages induced by co-pyrolysis of PVC and CaCO3. In the first stage, the PVC dehydrohalogenation takes place producing the majority of HCl. CaCO3 does not participate in the solid-phase reaction. In the second stage, the cyclization of olefin chains occurs with a low HCl production. The CaCO3 reacts under high temperature, absorbing HCl in crystal lattice producing CaCl2 and CO2. In the third stage, the CaCO3 continues consuming HCl, meanwhile it starts pyrolyzing above 800 °C, generating CaO and CO2. The final residue mainly consists of CaCl2 and CaO and the organic Cl is ignorable. As the Cl-capturing reactions occur under high temperature with a low HCl production, the efficiency of CaCO3 reducing HCl is low, which explains the findings in previous study. This paper reveals the solid-phase reaction scheme and the law of Cl migration of the PVC[sbnd]CaCO3 based polymer pyrolysis, providing fundamentals for modeling and contributing to the understanding of cable pyrolysis for incineration industry.
Published: 2021

46. Séquences de réduction durant le technocomplexe hoabinhien au Cambodge et en Thaïlande : Une nouvelle stratégie de taille de la pierre en Asie du Sud-Est au Pléistocène supérieur final et à l'Holocène moyen

Author: Forestier, Hubert, Zhou, Yuduan, Viallet, Cyril, Auetrakulvit, Prasit, Li, Yinghua, SOPHADY, Heng, Muséum national d'Histoire naturelle (MNHN), Wuhan University [China], Silpakorn University, Royal University of Phnom Penh (RUPP), and Silpakorn University [Bangkok, Thaïlande]
Subjects: ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2021

47. Room-temperature growth of covalent organic framework as stationary phase for open-tubular capillary electrochromatography

Author: Yuanyuan Fu, Igor Clarot, Zilin Chen, Zhengtao Li, Ariane Boudier, Qiaoyan Li, Wuhan University [China], University of Chinese Academy of Sciences [Beijing] (UCAS), Cibles thérapeutiques, formulation et expertise pré-clinique du médicament (CITHEFOR), and Université de Lorraine (UL)
Subjects: Capillary action, [SDV]Life Sciences [q-bio], Analytical chemistry, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Phenols, Capillary Electrochromatography, Spectroscopy, Fourier Transform Infrared, Electrochemistry, Environmental Chemistry, [CHIM]Chemical Sciences, Fourier transform infrared spectroscopy, Metal-Organic Frameworks, Spectroscopy, chemistry.chemical_classification, [PHYS]Physics [physics], Capillary electrochromatography, Chemistry, Biomolecule, Temperature, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Chlorobenzene, Covalent bond, Alkylbenzenes, 0210 nano-technology, Selectivity
Abstract: International audience; Covalent organic frameworks (COFs) is a class of porous materials with high surface area, high porosity, good stability and tunable structure that have been neatly used in the separation area. In this work, we have proposed the in-situ synthesis of a novel COF composed of 4,4',4''-(1,3,5-Triazine-2,4,6-triyl)trianiline (Tz) and 1,4-dihydroxyterephthalaldehyde (Da) onto the capillary inner surface for electrochromatographic separation. Fourier transform infrared spectroscopy (FT-IR), elemental analysis (EA) and scanning electron microscopy (SEM) have been facilitated to characterize the prepared capillary columns. The COF (TzDa) modified OT-CEC column exhibited satisfactory separation selectivity towards neutral compounds (such as chlorobenzenes and alkylbenzenes), acidic and basic compounds (such as phenols and anilines), food additives (vanillin and its analogues) and small biomolecules (such as amino acids and polypeptides). Furthermore, the TzDa modified capillary was quite stable and repeatable. The relative standard deviations for retention times of the test analytes (alkylbenzenes) were as follow: for intra-day (n = 3) runs (≤ 1.74%), inter-day (n = 3) runs (≤ 2.25%) and column to columns (n = 3) (≤ 4.83%). This new type of COF-based stationary phase has tremendous potential in separation science.
Published: 2021

48. Obfuscation-Resilient Executable Payload Extraction From Packed Malware

Author: Cheng, Binlin, Jiang, Ming, Leal, Erika, Zhang, Haotian, Fu, Jianming, Peng, Guojun, Marion, Jean-Yves, Hubei University, Wuhan University [China], University of Texas at Arlington [Arlington], Carbone (CARBONE), Department of Formal Methods (LORIA - FM), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Jiang Ming was supported by the National Science Foundation (NSF) under grant CNS-1850434., We thank the University of Texas at Arlington and the Department of Education for supporting us with a Graduate Assistance in Areas of National Need (GAANN) fellowship., This work was also supported in part by the National Natural Science Foundation of China grants (61972297, U1636107, and 61976085)., and European Project: 830927,CONCORDIA(2019)
Subjects: [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR]
Abstract: Over the past two decades, packed malware is always a veritable challenge to security analysts. Not only is determining the end of the unpacking increasingly difficult, but also advanced packers embed a variety of anti-analysis tricks to impede reverse engineering. As malware's APIs provide rich information about malicious behavior, one common anti-analysis strategy is API obfuscation, which removes the metadata of imported APIs from malware's PE header and complicates API name resolution from API callsites. In this way, even when security analysts obtain the unpacked code, a disassembler still fails to recognize imported API names, and the unpacked code cannot be successfully executed. Recently, generic binary unpacking has made breakthrough progress with noticeable performance improvement. However, reconstructing unpacked code's import tables, which is vital for further malware static/dynamic analyses, has largely been overlooked. Existing approaches are far from mature: they either can be easily evaded by various API obfuscation schemes (e.g., stolen code), or suffer from incomplete API coverage. In this paper, we aim to achieve the ultimate goal of Windows malware unpacking: recovering an executable malware program from the packed and obfuscated binary code. Based on the process memory when the original entry point (OEP) is reached, we develop a hardware-assisted tool,API-Xray, to reconstruct import tables. Import table reconstruction is challenging enough in its own right. Our core technique,API Micro Execution, explores all possible API callsites and executes them without knowing API argument values. At the same time, we take advantage of hardware tracing via Intel Branch Trace Store and NX bit to resolve API names and finally rebuild import tables. Compared with the previous work, API-Xray has a better resistance against various API obfuscation schemes and more coverage on resolved Windows API names. Since July 2019, we have tested API-Xray in practice to assist security professionals in malware analysis: we have successfully rebuilt 155,811 executable malware programs and substantially improved the detection rate for 7,514 unknown or new malware variants.
Published: 2021
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49. Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study

Author: Jean-Louis Teboul, Huibin Feng, Qianghong Xu, Jiao Liu, Lidi Zhang, Zhenliang Wen, Djillali Annane, Tao Wang, Yanfei Shen, Zhongyi Li, Jun Guo, Yongan Liu, Xuan Dong, Wei Zhu, Wenzhe Li, Dechang Chen, Yizhu Chen, Zhixiong Wu, Limin Chen, Hangxiang Du, Sisi Huang, Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Natural Science Foundation of China, NSFC: 81571943, 81873944, 81971869, This work was supported by the National Natural Science Foundation of China [81873944, 81971869, and 81571943]., Shanghai Jiao Tong University School of Medicine, Zhejiang Hospital [Hangzhou], Fudan University [Shanghai], Hubei Polytechnic University (HBPU), Wuhan Jinyintan Hospital [Wuhan, China] (WJH), Huazhong University of Science and Technology [Wuhan] (HUST), Wuhan University [China], Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Bicêtre, Hôpital Raymond Poincaré [AP-HP], and HAL UVSQ, Équipe
Subjects: 0301 basic medicine, Male, ARDS, Thymalfasin, Organ Dysfunction Scores, efficacy, law.invention, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, law, Immunology and Allergy, 030212 general & internal medicine, Hospital Mortality, non-recovery, Original Research, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Respiratory Distress Syndrome, Mortality rate, Incidence (epidemiology), Confounding, Acute kidney injury, Middle Aged, thymosin alpha 1, Prognosis, Intensive care unit, 3. Good health, Intensive Care Units, Treatment Outcome, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, disease severity, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, Cohort study, Adult, medicine.medical_specialty, Immunology, Risk Assessment, 03 medical and health sciences, Internal medicine, medicine, Humans, Aged, Retrospective Studies, business.industry, COVID-19, Retrospective cohort study, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, RC581-607, Length of Stay, medicine.disease, COVID-19 Drug Treatment, 030104 developmental biology, Logistic Models, Immunologic diseases. Allergy, business
Abstract: BackgroundThymosin alpha 1 (Tα1) is widely used to treat patients with COVID-19 in China; however, its efficacy remains unclear. This study aimed to explore the efficacy of Tα1 as a COVID-19 therapy.MethodsWe performed a multicenter cohort study in five tertiary hospitals in the Hubei province of China between December 2019 and March 2020. The patient non-recovery rate was used as the primary outcome.ResultsAll crude outcomes, including non-recovery rate (65/306 vs. 290/1,976, p = 0.003), in-hospital mortality rate (62/306 vs. 271/1,976, p = 0.003), intubation rate (31/306 vs. 106/1,976, p = 0.001), acute respiratory distress syndrome (ARDS) incidence (104/306 vs. 499/1,976, p = 0.001), acute kidney injury (AKI) incidence (26/306 vs. 66/1,976, p < 0.001), and length of intensive care unit (ICU) stay (14.9 ± 12.7 vs. 8.7 ± 8.2 days, p < 0.001), were significantly higher in the Tα1 treatment group. After adjusting for confounding factors, Tα1 use was found to be significantly associated with a higher non-recovery rate than non-Tα1 use (OR 1.5, 95% CI 1.1–2.1, p = 0.028). An increased risk of non-recovery rate associated with Tα1 use was observed in the patient subgroups with maximum sequential organ failure assessment (SOFA) scores ≥2 (OR 2.0, 95%CI 1.4–2.9, p = 0.024), a record of ICU admission (OR 5.4, 95%CI 2.1–14.0, p < 0.001), and lower PaO2/FiO2 values (OR 1.9, 95%CI 1.1–3.4, p = 0.046). Furthermore, later initiation of Tα1 use was associated with a higher non-recovery rate.ConclusionTα1 use in COVID-19 patients was associated with an increased non-recovery rate, especially in those with greater disease severity.
Published: 2021
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50. Polystyrene Hybrid-Vitrimer Based on the Hemiacetal Ester Exchange Reaction

Author: David Boucher, Nadine Pébère, Jeppe Madsen, Qian Huang, Nicolas Caussé, Liyun Yu, Claire Negrell, Vincent Ladmiral, Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole Nationale Supérieure de Chimie de Montpellier - ENSCM (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Technical University of Denmark (DENMARK), Université de Montpellier (FRANCE), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Danmarks Tekniske Universitet (DTU), Wuhan University [China], Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)
Subjects: Polymers and Plastics, Carboxylic acid, Butyl acrylate, Dimer, Matériaux, Ether, 010402 general chemistry, 01 natural sciences, Styrene, Inorganic Chemistry, chemistry.chemical_compound, Polymer chemistry, Organic compounds, Materials Chemistry, [CHIM]Chemical Sciences, Nucleic acid structure, Materials, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, 010405 organic chemistry, Copolymers, Organic Chemistry, 0104 chemical sciences, chemistry, Vitrimers, Hemiacetal, Polystyrene, Ethers
Abstract: Vitrimer materials, which are permanently cross-linked but reshapable polymers, are a class of materials of growing interest due to their potential in recycling and sustainable development. More precisely, vitrimers derived from commodity polymers could have a drastic impact on plastic consumption in the upcoming years. Here, the development of a polystyrene-based vitrimer harnessing the recently discovered hemiacetal ester exchange reaction of carboxylic acid is presented. 1,4-Cyclohexanedimethanol divinyl ether was reacted with 4-vinylbenzoic acid (VBA) to form a divinyl species containing two hemiacetal ester functions. This dimer was then copolymerized with styrene, butyl acrylate, and VBA to form a cross-linked material presenting pendent acid groups. This material exhibited three distinct behaviors at different temperature regimes: below 80 °C, despite the exchange reactions able to occur at this temperature, the cross-linked material behaved as a frozen material due to the hydrogen bonding formed by the carboxylic acid pendent groups. Between 80 and 130 °C, the vitrimer behavior was demonstrated by rheological creep experiments. At higher temperatures, the dissociation of the hemiacetal ester groups led to the loss of the covalent cross-linking.
Published: 2021

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