Search

Your search keyword '"Wu, Chen-Chi"' showing total 350 results
Start Over Author "Wu, Chen-Chi"
350 results on '"Wu, Chen-Chi"'

3. Emergence and Persistent Dominance of SARS-CoV-2 Omicron BA.2.3.7 Variant, Taiwan

Author

Shao, Pei-Lan, Tu, Hsiao-Chen, Gong, Yu-Nong, Shu, Hung-Yu, Kirby, Ralph, Hsu, Li-Yun, Yeo, Hui-Yee, Kuo, Han- Yueh, Huang, Yi-Chia, Lin, Yung-Feng, Weng, Hui-Ying, Wu, Yueh-Lin, Chen, Chien-Chih, Chen, Tzen-Wen, Lee, Kuo-Ming, Huang, Chung-Guei, Shih, Shin-Ru, Chen, Wei J., Wu, Chen-Chi, Yu, Chong-Jen, and Tsai, Shih-Feng

Subjects
Epidemics -- Causes of -- Distribution -- Taiwan, Company distribution practices, Health
Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, originated in China in late 2019, probably in the city of Wuhan (1,2). The outbreak of this unusual respiratory disease led to a wide [...]

Published
2023
Full Text
View/download PDF

9. Helical structure motifs made searchable for functional peptide design

Author

Tsai, Cheng-Yu, Salawu, Emmanuel Oluwatobi, Li, Hongchun, Lin, Guan-Yu, Kuo, Ting-Yu, Voon, Liyin, Sharma, Adarsh, Hu, Kai-Di, Cheng, Yi-Yun, Sahoo, Sobha, Stuart, Lutimba, Chen, Chih-Wei, Chang, Yuan-Yu, Lu, Yu-Lin, Ke, Simai, Ortiz, Christopher Llynard D., Fang, Bai-Shan, Wu, Chen-Chi, Lan, Chung-Yu, Fu, Hua-Wen, and Yang, Lee-Wei

Published
2022
Full Text
View/download PDF

15. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling

Author

Chang, Huang-Ming, Peng, Kang-Yung, Chan, Chieh-Kai, Sun, Chiao-Yin, Chen, Ying-Ying, Chang, Han-Mei, Huang, Chun-Lin, Liu, Pei-Chun, Chen, Peng-Ying, Wang, Kuo-Chuan, Wang, Wei-Jie, Wu, Chen-Chi, Lin, Yu-Feng, Lai, Tai-Shuan, Huang, Tao-Min, Young, Guang-Huar, Lin, Shuei-Liong, Ostermann, Marlies, Chu, Tzong-Shinn, Chueh, Jeff S., and Wu, Vin-Cent

Published
2021
Full Text
View/download PDF

16. Synthesis of Pigmented Parylene Coatings and Control of the Chromatism Based on Chemical Vapor Deposition Copolymerization.

Author

Wu, Ting‐Ying, Chuang, Chih‐Peng, Chou, Fang‐Yu, Chiang, Yu‐Chih, Jhang, Jia‐Rong, Guan, Zhen‐Yu, Chiu, Chih‐Hao, Huang, Sheng‐Tung, Wu, Chen‐Chi, and Chen, Hsien‐Yeh

Subjects
VAPOR-plating, SURFACE coatings, MEDICAL equipment
Abstract

Coloring and identification procedures for medical devices are important to reduce the risks of defective medical devices or incorrect operations and implantations. The study herein reports a novel platform of color pigment‐modified Parylene coatings to fulfill the needs of medical coatings, providing a surface modification route to alter the important property of color for an underlying material and/or device from its original color. Modification with a naphthalimide derivative is employed for the Parylene precursor. The synthesis of the final color Parylene coating is performed based on a vapor‐phase deposition polymerization process, and the coating is conformally coated on a variety of materials regardless of the shape or dimension. Furthermore, control of the color to create a series of color‐changing Parylene coatings is enabled by vapor deposition copolymerization with a second Parylene derivative source, and predictable color tuning from a primary to a secondary and/or tertiary color is achievable in the experiments and shows accordance with color theory. The reported coating platform represents a colored coating tool and is biocompatible for biotechnological applications. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Generation of induced pluripotent stem cells (IBMSi027-A) from a patient with hearing loss carrying WFS1 c.2051C > T (p.Ala684Val) variant

Author

Chan, Yen-Hui, primary, Tsai, Cheng-Yu, additional, Ho, Chang-Han, additional, Lu, Ying-Chang, additional, Lin, Pei-Hsuan, additional, Chen, Ta-Ching, additional, Chen, You-Tzung, additional, Huang, Cheng-Yen, additional, Liu, Tien-Chen, additional, Hsu, Chuan-Jen, additional, and Wu, Chen-Chi, additional

Published
2023
Full Text
View/download PDF

19. Genetic Underpinnings and Audiological Characteristics in Children With Unilateral Sensorineural Hearing Loss

Author

Lee, Chen‐Yu, primary, Lin, Pei‐Hsuan, additional, Chiang, Yu‐Ting, additional, Tsai, Cheng‐Yu, additional, Yang, Shu‐Yu, additional, Chen, You‐Mei, additional, Li, Chao‐Hsuan, additional, Lu, Chun‐Yi, additional, Liu, Tien‐Chen, additional, Hsu, Chuan‐Jen, additional, Chen, Pei‐Lung, additional, Hsu, Jacob Shujui, additional, and Wu, Chen‐Chi, additional

Published
2023
Full Text
View/download PDF

24. CRISPR/Cas9-mediated exon skipping to restore premature translation termination in a DFNB4 mouse model

Author

Huang, Chun-Ying, Tsai, Yi-Hsiu, Cheng, Yi-Fen, Wu, Peng-Yu, Chuang, Yu-Chi, Huang, Po-Yuan, Liu, Jai-Shin, Wu, Chen-Chi, and Cheng, Yen-Fu

Abstract

SLC26A4encodes pendrin, a crucial anion exchanger essential for maintaining hearing function. Mutations in SLC26A4, including the prevalent c.919-2 A > G splice-site mutation among East Asian individuals, can disrupt inner ear electrolyte balance, leading to syndromic and non-syndromic hearing loss, such as Pendred syndrome and DFNB4. To explore potential therapeutic strategies, we utilized CRISPR/Cas9-mediated exon skipping to create a Slc26a4∆E8+E9/∆E8+E9mouse model. We assessed pendrin expression in the inner ear and evaluated vestibular and auditory functions. The Slc26a4∆E8+E9/∆E8+E9mice demonstrated reframed pendrin in the inner ear and normal vestibular functions, contrasting with severely abnormal vestibular functions observed in the Slc26a4c.919-2 A > G splicing mutation mouse model. However, despite these molecular achievements, hearing function did not show the expected improvement, consistent with observed pathology, including cochlear hair cell loss and elevated hearing thresholds. Consequently, our findings highlight the necessity for alternative genetic editing strategies to address hearing loss caused by the SLC26A4c.919-2 A > G mutation.

Published
2024
Full Text
View/download PDF

27. Genetic Underpinnings and Audiological Characteristics in Children with Unilateral Sensorineural Hearing Loss

Author

Lee, Chen-Yu, primary, Lin, Pei-Hsuan, additional, Chiang, Yu-Ting, additional, Tsai, Cheng-Yu, additional, Yang, Shu-Yu, additional, Chen, You-Mei, additional, Li, Chao-Hsuan, additional, Lu, Chun-Yi, additional, Liu, Tien-Chen, additional, Hsu, Chuan-Jen, additional, Chen, Pei-Lung, additional, Hsu, Jacob Shujui, additional, and Wu, Chen-Chi, additional

Published
2022
Full Text
View/download PDF

33. Emergence and Persistent Dominance of Omicron BA.2.3.7 Variant in Community Outbreaks in Taiwan

Author

Shao, Pei-Lan, primary, Tu, Hsiao-Chen, additional, Gong, Yu-Nong, additional, Shu, Hung-Yu, additional, Kirby, Ralph, additional, Hsu, Li-Yun, additional, Yeo, Hui-Yee, additional, Kuo, Han-Yueh, additional, Huang, Yi-Chia, additional, Lin, Yung-Feng, additional, Weng, Hui-Ying, additional, Wu, Yueh-Lin, additional, Chen, Chien-Chih, additional, Chen, Tzen-Wen, additional, Lee, Kuo-Ming, additional, Huang, Chung-Guei, additional, Shih, Shin-Ru, additional, Chen, Wei J, additional, Wu, Chen-Chi, additional, Yu, Chong-Jen, additional, and Tsai, Shih-Feng, additional

Published
2022
Full Text
View/download PDF

34. Detecting VoIP Traffic Based on Human Conversation Patterns

Author

Wu, Chen-Chi, Chen, Kuan-Ta, Chang, Yu-Chun, Lei, Chin-Laung, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Schulzrinne, Henning, editor, State, Radu, editor, and Niccolini, Saverio, editor

Published
2008
Full Text
View/download PDF

35. Health Utilities of Bilateral Severe-to-Profound Hearing Loss with Assistive Devices.

Author

Chen, Yi-Wen, Lin, Pei-Hsuan, Fang, Te-Yung, Wu, Chen-Chi, Wang, Pa-Chun, Wang, Han, and Ko, Yu

Subjects
TREATMENT of hearing disorders, COCHLEAR implants, RESEARCH, STATISTICS, ANALYSIS of variance, CROSS-sectional method, VISUAL analog scale, INTERVIEWING, FISHER exact test, HEARING aids, COMPARATIVE studies, ASSISTIVE technology, EARLY intervention (Education), QUESTIONNAIRES, SOUND recordings, DESCRIPTIVE statistics, RESEARCH funding, DATA analysis software, DATA analysis, QUALITY-adjusted life years, CHILDREN
Abstract

Hearing loss is a common sensory disorder in newborns. Early intervention with assistive devices benefits children's auditory and speech performance. This study aimed to measure the health utilities of children with bilateral severe-to-profound hearing impairment with different assistive devices. The descriptions of four hypothetical health states were developed, and their utility values were obtained from healthcare professionals via the visual analogue scale (VAS) and time trade-off (TTO) methods. Thirty-seven healthcare professionals completed the TTO interview and were included in the analysis. The mean utility scores obtained via VAS were 0.31 for no assistive devices, 0.41 for bilateral hearing aids, 0.63 for bimodal hearing, and 0.82 for bilateral cochlear implants. As for the utility scores obtained via TTO, mean values were 0.60, 0.69, 0.81, and 0.90, respectively. None of the four groups had the same VAS- or TTO-elicited utility (p < 0.001). The post hoc test results showed that the difference was significant between any two groups (all p < 0.05). In conclusion, this study elicited health utility of bilateral hearing impairment with different assistive devices using the VAS and TTO methods. The utility values obtained provide critical data for future cost–utility analysis and health technology assessment. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

37. Cochlear Implantation Outcomes in Patients with Auditory Neuropathy Spectrum Disorder of Genetic and Non-Genetic Etiologies: A Multicenter Study

Author

Lin, Pei-Hsuan, primary, Wu, Hung-Pin, additional, Wu, Che-Ming, additional, Chiang, Yu-Ting, additional, Hsu, Jacob Shujui, additional, Tsai, Cheng-Yu, additional, Wang, Han, additional, Tseng, Li-Hui, additional, Chen, Pey-Yu, additional, Yang, Ting-Hua, additional, Hsu, Chuan-Jen, additional, Chen, Pei-Lung, additional, Wu, Chen-Chi, additional, and Liu, Tien-Chen, additional

Published
2022
Full Text
View/download PDF

44. Hearing Features and Cochlear Implantation Outcomes in Patients With PathogenicMYO15AVariants: a Multicenter Observational Study

Author

Chen, Pey-Yu, primary, Tsai, Cheng-Yu, additional, Wu, Jiunn-Liang, additional, Li, Yi-Lu, additional, Wu, Che-Ming, additional, Chen, Kuang-Chao, additional, Hwang, Chung-Feng, additional, Wu, Hung-Pin, additional, Lin, Hung-Ching, additional, Cheng, Yen-Fu, additional, Lo, Ming-Yu, additional, Liu, Tien-Chen, additional, Yang, Ting-Hua, additional, Chen, Pei-Lung, additional, Hsu, Chuan-Jen, additional, and Wu, Chen-Chi, additional

Published
2021
Full Text
View/download PDF

45. Preimplantation Genetic Diagnosis in Hereditary Hearing Impairment

Author

Chen, Hsin-Lin, primary, Lin, Pei-Hsuan, additional, Chiang, Yu-Ting, additional, Huang, Wen-Jie, additional, Lin, Chi-Fang, additional, Ma, Gwo-Chin, additional, Chang, Shun-Ping, additional, Fan, Jun-Yang, additional, Lin, Shin-Yu, additional, Wu, Chen-Chi, additional, and Chen, Ming, additional

Published
2021
Full Text
View/download PDF

47. Identification of nine novel variants across PAX3, SOX10, EDNRB, and MITF genes in Waardenburg syndrome with next‐generation sequencing.

Author

Lee, Chen‐Yu, Lo, Ming‐Yu, Chen, You‐Mei, Lin, Pei‐Hsuan, Hsu, Chuan‐Jen, Chen, Pei‐Lung, Wu, Chen‐Chi, and Hsu, Jacob Shujui

Subjects
NUCLEOTIDE sequencing, SOX transcription factors, PHENOTYPIC plasticity, GENETIC variation, GENETIC disorder diagnosis
Abstract

Background: Waardenburg syndrome (WS) is a hereditary, genetically heterogeneous disorder characterized by variable presentations of sensorineural hearing impairment and pigmentation anomalies. This study aimed to investigate the clinical features of WS in detail and determine the genetic causes of patients with clinically suspected WS. Methods: A total of 24 patients from 21 Han‐Taiwanese families were enrolled and underwent comprehensive physical and audiological examinations. We applied targeted next‐generation sequencing (NGS) to investigate the potential causative variants in these patients and further validated the candidate variants through Sanger sequencing. Results: We identified 19 causative variants of WS in our cohort. Of these variants, nine were novel and discovered in PAX3, SOX10, EDNRB, and MITF genes, including missense, nonsense, deletion, and splice site variants. Several patients presented with skeletal deformities, hypotonia, megacolon, and neurological disorders that were rarely seen in WS. Conclusion: This study revealed highly phenotypic variability in Taiwanese WS patients and demonstrated that targeted NGS allowed us to clarify the genetic diagnosis and extend the genetic variant spectrum of WS. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

48. Hearing Impairment with Monoallelic GJB2 Variants

Author

Lin, Yi-Hsin, primary, Wu, Ping-Che, additional, Tsai, Cheng-Yu, additional, Lin, Yin-Hung, additional, Lo, Ming-Yu, additional, Hsu, Shu-Jui, additional, Lin, Pei-Hsuan, additional, Erdenechuluun, Jargalkhuu, additional, Wu, Hung-Pin, additional, Hsu, Chuan-Jen, additional, Wu, Chen-Chi, additional, and Chen, Pei-Lung, additional

Published
2021
Full Text
View/download PDF

50. Seroprevalence Surveys for Anti-SARS-CoV-2 Antibody in Different Populations in Taiwan With Low Incidence of COVID-19 in 2020 and Severe Outbreaks of SARS in 2003

Author

Tseng, Wen-Pin, primary, Wu, Jhong-Lin, additional, Wu, Chen-Chi, additional, Kuo, Kuan-Ting, additional, Lin, Chien-Hao, additional, Chung, Ming-Yi, additional, Lee, Ya-Fan, additional, Yang, Bey-Jing, additional, Huang, Chien-Hua, additional, Chen, Shey-Ying, additional, Yu, Chong-Jen, additional, Chen, Shyr-Chyr, additional, and Hsueh, Po-Ren, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results