931 results on '"Worek, Franz"'
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2. Protein networking: nicotinic acetylcholine receptors and their protein–protein-associations
3. Effects of the nerve agent VX on hiPSC-derived motor neurons
4. Trauma-toxicology: concepts, causes, complications
5. Targeting miR-497-5p rescues human keratinocyte dysfunction upon skin exposure to sulfur mustard
6. Recombinant cellular model system for human muscle-type nicotinic acetylcholine receptor α1₂β1δε
7. Disulfide-adducts with cysteine residues in human serum albumin prove exposure to malodorous mercaptans in vitro
8. Development of a scintillation proximity assay for [3H]epibatidine binding sites of Tetronarce californica muscle-type nicotinic acetylcholine receptor
9. Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
10. Determination of tissue distribution of VX and its metabolites EMPA and EA-2192 in various rat tissues by LC-ESI-MS/MS after phosphotriesterase treatment
11. Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents
12. The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms – Structure optimization
13. Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
14. Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication
15. Suitability of human HepaRG cells and liver spheroids as in vitro model to investigate the bioactivation of the organothiophosphate pesticide parathion
16. Evidence of nerve agent VX exposure in rat plasma by detection of albumin-adducts in vitro and in vivo
17. Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor
18. Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes – Structure-activity relationships
19. Toxicokinetic analysis of the highly toxic nerve agent VX in commercially available multi-organ-chips – Ways to overcome compound absorption
20. MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor
21. AChE reactivation in precision-cut lung slices following organophosphorus compound poisoning
22. The suitability of a polydimethylsiloxane-based (PDMS) microfluidic two compartment system for the toxicokinetic analysis of organophosphorus compounds
23. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
24. A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
25. Post-VX exposure treatment of rats with engineered phosphotriesterases
26. Cell-Sonar, a Novel Method for Intracellular Tracking of Secretory Pathways.
27. Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense
28. Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
29. Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample
30. Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro
31. Konstruktion und gentechnische Herstellung katalytischer Bioscavenger zur Detoxifizierung phosphororganischer Verbindungen
32. Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
33. 44th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), 28–31 May 2024, Munich, Germany.
34. The influence of the model pesticides parathion and paraoxon on human cytochrome P450 and associated oxygenases in HepaRG cells.
35. Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks
36. A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds
37. Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by 31P-NMR spectroscopy
38. Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
39. Trauma-toxicology: concepts, causes, complications
40. Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon
41. Vergiftungen durch chemische Kampfstoffe
42. Human small bowel as model for poisoning with organophosphorus compounds
43. List of contributors
44. Toxicokinetic aspects of nerve agents and vesicants
45. Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl
46. Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM
47. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
48. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity—An in vitro structure-activity analysis
49. Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism
50. Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning
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