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1,047 results on '"Woods, B."'

1. Delocalized states in three-terminal superconductor-semiconductor nanowire devices

Author

Yu, P., Woods, B. D., Chen, J., Badawy, G., Bakkers, E. P. A. M., Stanescu, T. D., and Frolov, S. M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We fabricate three-terminal hybrid devices with a nanowire segment proximitized by a superconductor, and with two tunnel probe contacts on either side of that segment. We perform simultaneous tunneling measurements on both sides. We identify some states as delocalized above-gap states observed on both ends, and some states as localized near one of the tunnel barriers. Delocalized states can be traced from zero to finite magnetic fields beyond 0.5 T. In the parameter regime of delocalized states, we search for correlated subgap resonances required by the Majorana zero mode hypothesis. While both sides exhibit ubiquitous low-energy features at high fields, no correlation is inferred. Simulations using a one-dimensional effective model suggest that delocalized states may belong to lower one-dimensional subbands, while the localized states originate from higher subbands. To avoid localization in higher subbands, disorder may need to be further reduced to realize Majorana zero modes., Comment: Original data available at https://zenodo.org/record/3958243

Published
2021
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2. A Variable Neighbourhood Descent Heuristic for Conformational Search Using a Quantum Annealer

Author

Marchand, D. J. J., Noori, M., Roberts, A., Rosenberg, G., Woods, B., Yildiz, U., Coons, M., Devore, D., and Margl, P.

Subjects
Quantum Physics
Abstract

Discovering the low-energy conformations of a molecule is of great interest to computational chemists, with applications in {\em in silico} materials design and drug discovery. In this paper, we propose a variable neighbourhood search heuristic for the conformational search problem. Using the structure of a molecule, neighbourhoods are chosen to allow for the efficient use of a binary quadratic optimizer for conformational search. The method is flexible with respect to the choice of molecular force field and the number of discretization levels in the search space, and can be further generalized to take advantage of higher-order binary polynomial optimizers. It is well-suited for the use of devices such as quantum annealers. After carefully defining neighbourhoods, the method easily adapts to the size and topology of these devices, allowing for seamless scaling alongside their future improvements.

Published
2018

3. 'Bridge-builders' and 'boundary spanners': a qualitative study of youth workers' perceptions of their roles and practices with vulnerable young people in school-based settings.

Author

Corney, T., Gorman, J., Woods, B., Benedict, N., and Law, A.

Subjects
YOUTH workers (Social services), HOMELESSNESS, STUDENT attitudes, FAMILY support
Abstract

This paper presents a qualitative study of 22 youth workers' perceptions of their roles and practices in seven school-based settings in a large post-industrial city in regional Australia. Youth workers are often engaged in school-based settings working with vulnerable young people, yet knowledge of how workers perceive and conceptualize their role and practice in these settings remains limited. Through focus group interviews, youth workers were asked how they engage, and work with vulnerable students, how they conceptualize their roles and the bodies of knowledge to which those practices and roles pertain. We find that youth work in school-based settings requires the dynamic and non-linear application of the practices of youth accompaniment, family support and youth-centred advocacy, underpinned by respect for the dignity, autonomy and agency of the young person. We argue that the complex application of these practices positions youth workers as 'bridge-builders' and 'boundary-spanners'. Bridge-builders assist young people to connect and engage with support services. Boundary-spanners build relationships across service providers to network different organizations and professionals for better collaboration and support of young people. These findings have implications for youth policy and practice in the area of youth work with vulnerable young people in school-based settings. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS)

Author

Green, E, Gao, L, Barnes, R, Arthur, A, Baldwin, C, Barnes, L E, Brayne, C, Comas-Herrera, A, Dening, T, Forster, G, Harrison, S, Ince, P G, Jagger, C, Matthews, F E, McKeith, I G, Parry, B, Pickett, J, Robinson, L, Stephan, B C M, Wharton, S, Wittenberg, R, Woods, B, Weller, R, Kingston, Andrew, Wohland, Pia, Wittenberg, Raphael, Robinson, Louise, Brayne, Carol, Matthews, Fiona E, and Jagger, Carol

Published
2017
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17. DIVERGING FROM A SOLUTION: ANALYZING THE SUPREME COURT'S OBSTRUCTION OF PROGRESSIVE CLIMATE POLICIES THROUGH THE LENS OF THE CLEAN WATER ACT.

Author

Woods, B. Noah

Subjects
*ENVIRONMENTAL protection, *WETLANDS, *JUDGES, *ENVIRONMENTAL policy, *CLEAN Water Act of 1972, *CLIMATE change
Abstract

The article looks at how conservative Justices have undermined the extent of federal wetland protections available under the Clean Water Act. Topics include an analysis of the U.S. Supreme Court's push to gain control over environmental policy, caselaw surrounding wetland jurisdictional disputes to examine how conservative Justices have reduced federal wetland protections, and developments in Court jurisprudence that threatens the public's interest in mitigating the impacts of climate change.

Published
2024

18. New insights into the genetic etiology of Alzheimer's disease and related dementias

Author

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., Yaqub, A., Prokic, I., Chapuis, J., Ahmad, S., Giedraitis, V., Aarsland, D., Garcia-Gonzalez, P., Abdelnour, C., Alarcón-Martín, E., Alcolea, D., Alegret, M., Alvarez, I., Álvarez, V., Armstrong, N. J., Tsolaki, A., Antúnez, C., Appollonio, I., Arcaro, M., Archetti, S., Pastor, A. A., Arosio, B., Athanasiu, L., Bailly, H., Banaj, N., Baquero, M., Barral, S., Beiser, A., Pastor, A. B., Below, J. E., Benchek, P., Benussi, L., Berr, C., Besse, C., Bessi, V., Binetti, G., Bizarro, A., Blesa, R., Boada, M., Boerwinkle, E., Borroni, B., Boschi, S., Bossù, P., Bråthen, G., Bressler, J., Bresner, C., Brodaty, H., Brookes, K. J., Brusco, L. I., Buiza-Rueda, D., Bûrger, K., Burholt, V., Bush, W. S., Calero, M., Cantwell, L. B., Chene, G., Chung, J., Cuccaro, M. L., Carracedo, Á., Cecchetti, R., Cervera-Carles, L., Charbonnier, C., Chen, H. -H., Chillotti, C., Ciccone, S., Claassen, J. A. H. R., Clark, C., Conti, E., Corma-Gómez, A., Costantini, E., Custodero, C., Daian, D., Dalmasso, M. C., Daniele, A., Dardiotis, E., Dartigues, J. -F., de Deyn, P. P., de Paiva Lopes, K., de Witte, L. D., Debette, S., Deckert, J., del Ser, T., Denning, N., Destefano, A., Dichgans, M., Diehl-Schmid, J., Diez-Fairen, M., Rossi, P. D., Djurovic, S., Duron, E., Düzel, E., Dufouil, C., Eiriksdottir, G., Engelborghs, S., Escott-Price, V., Espinosa, A., Ewers, M., Faber, K. M., Fabrizio, T., Nielsen, S. F., Fardo, D. W., Farotti, L., Fenoglio, C., Fernández-Fuertes, M., Ferrari, R., Ferreira, C. B., Ferri, E., Fin, B., Fischer, P., Fladby, T., Fließbach, K., Fongang, B., Fornage, M., Fortea, J., Foroud, T. M., Fostinelli, S., Fox, N. C., Franco-Macías, E., Bullido, M. J., Frank-García, A., Froelich, L., Fulton-Howard, B., Galimberti, D., García-Alberca, J. M., García-González, P., Garcia-Madrona, S., Garcia-Ribas, G., Ghidoni, R., Giegling, I., Giorgio, G., Goate, A. M., Goldhardt, O., Gomez-Fonseca, D., González-Pérez, A., Graff, C., Grande, G., Green, E., Grimmer, T., Grünblatt, E., Grunin, M., Gudnason, V., Guetta-Baranes, T., Haapasalo, A., Hadjigeorgiou, G., Haines, J. L., Hamilton-Nelson, K. L., Hampel, H., Hanon, O., Hardy, J., Hartmann, A. M., Hausner, L., Harwood, J., Heilmann-Heimbach, S., Helisalmi, S., Heneka, M. T., Hernández, I., Herrmann, M. J., Hoffmann, P., Holmes, C., Holstege, H., Vilas, R. H., Hulsman, M., Humphrey, J., Biessels, G. J., Jian, X., Johansson, C., Jun, G. R., Kastumata, Y., Kauwe, J., Kehoe, P. G., Kilander, L., Ståhlbom, A. K., Kivipelto, M., Koivisto, A., Kornhuber, J., Kosmidis, M. H., Kukull, W. A., Kuksa, P. P., Kunkle, B. W., Kuzma, A. B., Lage, C., Laukka, E. J., Launer, L., Lauria, A., Lee, C. -Y., Lehtisalo, J., Lerch, O., Lleó, A., Longstreth, W., Lopez, O., de Munain, A. L., Love, S., Löwemark, M., Luckcuck, L., Lunetta, K. L., Ma, Y., Macías, J., Macleod, C. A., Maier, W., Mangialasche, F., Spallazzi, M., Marquié, M., Marshall, R., Martin, E. R., Montes, A. M., Rodríguez, C. M., Masullo, C., Mayeux, R., Mead, S., Mecocci, P., Medina, M., Meggy, A., Mehrabian, S., Mendoza, S., Menéndez-González, M., Mir, P., Moebus, S., Mol, M., Molina-Porcel, L., Montrreal, L., Morelli, L., Moreno, F., Morgan, K., Mosley, T., Nöthen, M. M., Muchnik, C., Mukherjee, S., Nacmias, B., Ngandu, T., Nicolas, G., Nordestgaard, B. G., Olaso, R., Orellana, A., Orsini, M., Ortega, G., Padovani, A., Paolo, C., Papenberg, G., Parnetti, L., Pasquier, F., Pastor, P., Peloso, G., Pérez-Cordón, A., Pérez-Tur, J., Pericard, P., Peters, O., Pijnenburg, Y. A. L., Pineda, J. A., Piñol-Ripoll, G., Pisanu, C., Polak, T., Popp, J., Posthuma, D., Priller, J., Puerta, R., Quenez, O., Quintela, I., Thomassen, J. Q., Rábano, A., Rainero, I., Rajabli, F., Ramakers, I., Real, L. M., Reinders, M. J. T., Reitz, C., Reyes-Dumeyer, D., Ridge, P., Riedel-Heller, S., Riederer, P., Roberto, N., Rodriguez-Rodriguez, E., Rongve, A., Allende, I. R., Rosende-Roca, M., Royo, J. L., Rubino, E., Rujescu, D., Sáez, M. E., Sakka, P., Saltvedt, I., Sanabria, Á., Sánchez-Arjona, M. B., Sanchez-Garcia, F., Juan, P. S., Sánchez-Valle, R., Sando, S. B., Sarnowski, C., Satizabal, C. L., Scamosci, M., Scarmeas, N., Scarpini, E., Scheltens, P., Scherbaum, N., Scherer, M., Schmid, M., Schneider, A., Schott, J. M., Selbæk, G., Seripa, D., Serrano, M., Sha, J., Shadrin, A. A., Skrobot, O., Slifer, S., Snijders, G. J. L., Soininen, H., Solfrizzi, V., Solomon, A., Song, Y. E., Sorbi, S., Sotolongo-Grau, O., Spalletta, G., Spottke, A., Squassina, A., Stordal, E., Tartan, J. P., Tárraga, L., Tesí, N., Thalamuthu, A., Thomas, T., Tosto, G., Traykov, L., Tremolizzo, L., Tybjærg-Hansen, A., Uitterlinden, A., Ullgren, A., Ulstein, I., Valero, S., Valladares, O., Broeckhoven, C. V., Vance, J., Vardarajan, B. N., van der Lugt, A., Dongen, J. V., van Rooij, J., van Swieten, J., Vandenberghe, R., Verhey, F., Vidal, J. -S., Vogelgsang, J., Vyhnalek, M., Wagner, M., Wallon, D., Wang, L. -S., Wang, R., Weinhold, L., Wiltfang, J., Windle, G., Woods, B., Yannakoulia, M., Zare, H., Zhao, Y., Zhang, X., Zhu, C., Zulaica, M., Laczo, J., Matoska, V., Serpente, M., Assogna, F., Piras, F., Ciullo, V., Shofany, J., Ferrarese, C., Andreoni, S., Sala, G., Zoia, C. P., Zompo, M. D., Benussi, A., Bastiani, P., Takalo, M., Natunen, T., Laatikainen, T., Tuomilehto, J., Antikainen, R., Strandberg, T., Lindström, J., Peltonen, M., Abraham, R., Al-Chalabi, A., Bass, N. J., Brayne, C., Brown, K. S., Collinge, J., Craig, D., Deloukas, P., Fox, N., Gerrish, A., Gill, M., Gwilliam, R., Harold, D., Hollingworth, P., Johnston, J. A., Jones, L., Lawlor, B., Livingston, G., Lovestone, S., Lupton, M., Lynch, A., Mann, D., Mcguinness, B., Mcquillin, A., O’Donovan, M. C., Owen, M. J., Passmore, P., Powell, J. F., Proitsi, P., Rossor, M., Shaw, C. E., Smith, A. D., Gurling, H., Todd, S., Mummery, C., Ryan, N., Lacidogna, G., Adarmes-Gómez, A., Mauleón, A., Pancho, A., Gailhajenet, A., Lafuente, A., Macias-García, D., Martín, E., Pelejà, E., Carrillo, F., Merlín, I. S., Garrote-Espina, L., Vargas, L., Carrion-Claro, M., Marín, M., Labrador, M., Buendia, M., Alonso, M. D., Guitart, M., Moreno, M., Ibarria, M., Periñán, M., Aguilera, N., Gómez-Garre, P., Cañabate, P., Escuela, R., Pineda-Sánchez, R., Vigo-Ortega, R., Jesús, S., Preckler, S., Rodrigo-Herrero, S., Diego, S., Vacca, A., Roveta, F., Salvadori, N., Chipi, E., Boecker, H., Laske, C., Perneczky, R., Anastasiou, C., Janowitz, D., Malik, R., Anastasiou, A., Parveen, K., López-García, S., Antonell, A., Mihova, K. Y., Belezhanska, D., Weber, H., Kochen, S., Solis, P., Medel, N., Lisso, J., Sevillano, Z., Politis, D. G., Cores, V., Cuesta, C., Ortiz, C., Bacha, J. I., Rios, M., Saenz, A., Abalos, M. S., Kohler, E., Palacio, D. L., Etchepareborda, I., Kohler, M., Novack, G., Prestia, F. A., Galeano, P., Castaño, E. M., Germani, S., Toso, C. R., Rojo, M., Ingino, C., Mangone, C., Rubinsztein, D. C., Teipel, S., Fievet, N., Deramerourt, V., Forsell, C., Thonberg, H., Bjerke, M., Roeck, E. D., Martínez-Larrad, M. T., Olivar, N., Cano, A., Macias, J., Maroñas, O., Nuñez-Llaves, R., Olivé, C., Adarmes-Gómez, A. D., Amer-Ferrer, G., Antequera, M., Burguera, J. A., Casajeros, M. J., Martinez de Pancorbo, M., Hevilla, S., Espinosa, M. A. L., Legaz, A., Manzanares, S., Marín-Muñoz, J., Marín, T., Martínez, B., Martínez, V., Martínez-Lage Álvarez, P., Iriarte, M. M., Periñán-Tocino, M. T., Real de Asúa, D., Rodrigo, S., Sastre, I., Vicente, M. P., Vivancos, L., Epelbaum, J., Hannequin, D., Campion, D., Deramecourt, V., Tzourio, C., Brice, A., Dubois, B., Williams, A., Thomas, C., Davies, C., Nash, W., Dowzell, K., Morales, A. C., Bernardo-Harrington, M., Turton, J., Lord, J., Brown, K., Vardy, E., Fisher, E., Warren, J. D., Ryan, N. S., Guerreiro, R., Uphill, J., Bass, N., Heun, R., Kölsch, H., Schürmann, B., Lacour, A., Herold, C., Powell, J., Patel, Y., Hodges, A., Becker, T., Warden, D., Wilcock, G., Clarke, R., Ben-Shlomo, Y., Hooper, N. M., Pickering-Brown, S., Sussams, R., Warner, N., Bayer, A., Heuser, I., Drichel, D., Klopp, N., Mayhaus, M., Riemenschneider, M., Pinchler, S., Feulner, T., Gu, W., van den Bussche, H., Hüll, M., Frölich, L., Wichmann, H. -E., Jöckel, K. -H., O’Donovan, M., Owen, M., Bahrami, S., Bosnes, I., Selnes, P., Bergh, S., Palotie, A., Daly, M., Jacob, H., Matakidou, A., Runz, H., John, S., Plenge, R., Mccarthy, M., Hunkapiller, J., Ehm, M., Waterworth, D., Fox, C., Malarstig, A., Klinger, K., Call, K., Behrens, T., Loerch, P., Mäkelä, T., Kaprio, J., Virolainen, P., Pulkki, K., Kilpi, T., Perola, M., Partanen, J., Pitkäranta, A., Kaarteenaho, R., Vainio, S., Turpeinen, M., Serpi, R., Laitinen, T., Mäkelä, J., Kosma, V. -M., Kujala, U., Tuovila, O., Hendolin, M., Pakkanen, R., Waring, J., Riley-Gillis, B., Liu, J., Biswas, S., Diogo, D., Marshall, C., Hu, X., Gossel, M., Graham, R., Cummings, B., Ripatti, S., Schleutker, J., Arvas, M., Carpén, O., Hinttala, R., Kettunen, J., Mannermaa, A., Laukkanen, J., Julkunen, V., Remes, A., Kälviäinen, R., Peltola, J., Tienari, P., Rinne, J., Ziemann, A., Esmaeeli, S., Smaoui, N., Lehtonen, A., Eaton, S., Lahdenperä, S., van Adelsberg, J., Michon, J., Kerchner, G., Bowers, N., Teng, E., Eicher, J., Mehta, V., Gormley, P., Linden, K., Whelan, C., Xu, F., Pulford, D., Färkkilä, M., Pikkarainen, S., Jussila, A., Blomster, T., Kiviniemi, M., Voutilainen, M., Georgantas, B., Heap, G., Rahimov, F., Usiskin, K., Lu, T., Oh, D., Kalpala, K., Miller, M., Mccarthy, L., Eklund, K., Palomäki, A., Isomäki, P., Pirilä, L., Kaipiainen-Seppänen, O., Huhtakangas, J., Lertratanakul, A., Hochfeld, M., Bing, N., Gordillo, J. E., Mars, N., Pelkonen, M., Kauppi, P., Kankaanranta, H., Harju, T., Close, D., Greenberg, S., Chen, H., Betts, J., Ghosh, S., Salomaa, V., Niiranen, T., Juonala, M., Metsärinne, K., Kähönen, M., Junttila, J., Laakso, M., Pihlajamäki, J., Sinisalo, J., Taskinen, M. -R., Tuomi, T., Challis, B., Peterson, A., Chu, A., Parkkinen, J., Muslin, A., Joensuu, H., Meretoja, T., Aaltonen, L., Mattson, J., Auranen, A., Karihtala, P., Kauppila, S., Auvinen, P., Elenius, K., Popovic, R., Schutzman, J., Loboda, A., Chhibber, A., Lehtonen, H., Mcdonough, S., Crohns, M., Kulkarni, D., Kaarniranta, K., Turunen, J. A., Ollila, T., Seitsonen, S., Uusitalo, H., Aaltonen, V., Uusitalo-Järvinen, H., Luodonpää, M., Hautala, N., Loomis, S., Strauss, E., Podgornaia, A., Hoffman, J., Tasanen, K., Huilaja, L., Hannula-Jouppi, K., Salmi, T., Peltonen, S., Koulu, L., Harvima, I., Wu, Y., Choy, D., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Siponen, M., Suominen, L., Mäntylä, P., Gursoy, U., Anttonen, V., Sipilä, K., Davis, J. W., Quarless, D., Petrovski, S., Wigmore, E., Chen, C. -Y., Bronson, P., Tsai, E., Huang, Y., Maranville, J., Shaikho, E., Mohammed, E., Wadhawan, S., Kvikstad, E., Caliskan, M., Chang, D., Bhangale, T., Pendergrass, S., Holzinger, E., Chen, X., Hedman, Å., King, K. S., Wang, C., Xu, E., Auge, F., Chatelain, C., Rajpal, D., Liu, D., Xia, T. -H., Brauer, M., Kurki, M., Karjalainen, J., Havulinna, A., Jalanko, A., Palta, P., della Briotta Parolo, P., Zhou, W., Lemmelä, S., Rivas, M., Harju, J., Lehisto, A., Ganna, A., Llorens, V., Laivuori, H., Rüeger, S., Niemi, M. E., Tukiainen, T., Reeve, M. P., Heyne, H., Palin, K., Garcia-Tabuenca, J., Siirtola, H., Kiiskinen, T., Lee, J., Tsuo, K., Elliott, A., Kristiansson, K., Hyvärinen, K., Ritari, J., Koskinen, M., Pylkäs, K., Kalaoja, M., Karjalainen, M., Mantere, T., Kangasniemi, E., Heikkinen, S., Laakkonen, E., Sipeky, C., Heron, S., Karlsson, A., Jambulingam, D., Rathinakannan, V. S., Kajanne, R., Aavikko, M., Jiménez, M. G., della Briotta Parola, P., Kanai, M., Kaunisto, M., Kilpeläinen, E., Sipilä, T. P., Brein, G., Awaisa, G., Shcherban, A., Donner, K., Loukola, A., Laiho, P., Sistonen, T., Kaiharju, E., Laukkanen, M., Järvensivu, E., Lähteenmäki, S., Männikkö, L., Wong, R., Mattsson, H., Hiekkalinna, T., Paajanen, T., Pärn, K., Gracia-Tabuenca, J., Abner, E., Adams, P. M., Aguirre, A., Albert, M. S., Albin, R. L., Allen, M., Alvarez, L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Ayres, G., Baldwin, C. T., Barber, R. C., Barnes, L. L., Beach, T. G., Becker, J. T., Beecham, G. W., Beekly, D., Benitez, B. A., Bennett, D., Bertelson, J., Margaret, F. E., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Brewer, J., Burke, J. R., Burns, J. M., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Chasse, S., Chesselet, M. -F., Chesi, A., Chin, N. A., Chui, H. C., Craft, S., Crane, P. K., Cribbs, D. H., Crocco, E. A., Cruchaga, C., Cullum, M., Darby, E., Davis, B., De Jager, P. L., Decarli, C., Detoledo, J., Dick, M., Dickson, D. W., Dombroski, B. A., Doody, R. S., Duara, R., Ertekin-Taner, N., Evans, D. A., Fairchild, T. J., Fallon, K. B., Farlow, M. R., Farrell, J. J., Fernandez-Hernandez, V., Ferris, S., Frosch, M. P., Galasko, D. R., Gamboa, A., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Grabowski, T. J., Graff-Radford, N. R., Grant, S. F. A., Green, R. C., Growdon, J. H., Hakonarson, H., Hall, J., Hamilton, R. L., Harari, O., Harrell, L. E., Haut, J., Head, E., Henderson, V. W., Hernandez, M., Hohman, T., Honig, L. S., Huebinger, R. M., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Hynan, L. S., Ibanez, L., Jarvik, G. P., Jayadev, S., Jin, L. -W., Johnson, K., Johnson, L., Kamboh, M. I., Karydas, A. M., Katz, M. J., Kaye, J. A., Keene, C. D., Khaleeq, A., Kim, R., Knebl, J., Kowall, N. W., Kramer, J. H., Laferla, F. M., Lah, J. J., Larson, E. B., Lee, E. B., Lerner, A., Leung, Y. Y., Leverenz, J. B., Levey, A. I., Li, M., Lieberman, A. P., Lipton, R. B., Logue, M., Lyketsos, C. G., Malamon, J., Mains, D., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., Massman, P., Masurkar, A., Mccormick, W. C., Mccurry, S. M., Mcdavid, A. N., Mckee, A. C., Mesulam, M., Mez, J., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Monuki, E. S., Morris, J. C., Myers, A. J., Nguyen, T., O’Bryant, S., Olichney, J. M., Ory, M., Palmer, R., Parisi, J. E., Paulson, H. L., Pavlik, V., Paydarfar, D., Perez, V., Peskind, E., Petersen, R. C., Phillips-Cremins, J. E., Pierce, A., Polk, M., Poon, W. W., Potter, H., Qu, L., Quiceno, M., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reisch, J. S., Ringman, J. M., Roberson, E. D., Rodriguear, M., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Small, S., Smith, A. G., Smith, J. P., Sonnen, J. A., Spina, S., George-Hyslop, P. 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M, Rossi, P, Djurovic, S, Duron, E, Düzel, E, Dufouil, C, Eiriksdottir, G, Engelborghs, S, Escott-Price, V, Espinosa, A, Ewers, M, Faber, K, Fabrizio, T, Nielsen, S, Fardo, D, Farotti, L, Fenoglio, C, Fernández-Fuertes, M, Ferrari, R, Ferreira, C, Ferri, E, Fin, B, Fischer, P, Fladby, T, Fließbach, K, Fongang, B, Fornage, M, Fortea, J, Foroud, T, Fostinelli, S, Fox, N, Franco-Macías, E, Bullido, M, Frank-García, A, Froelich, L, Fulton-Howard, B, Galimberti, D, García-Alberca, J, García-González, P, Garcia-Madrona, S, Garcia-Ribas, G, Ghidoni, R, Giegling, I, Giorgio, G, Goate, A, Goldhardt, O, Gomez-Fonseca, D, González-Pérez, A, Graff, C, Grande, G, Green, E, Grimmer, T, Grünblatt, E, Grunin, M, Gudnason, V, Guetta-Baranes, T, Haapasalo, A, Hadjigeorgiou, G, Haines, J, Hamilton-Nelson, K, Hampel, H, Hanon, O, Hardy, J, Hartmann, A, Hausner, L, Harwood, J, Heilmann-Heimbach, S, Helisalmi, S, Heneka, M, Hernández, I, Herrmann, M, Hoffmann, P, Holmes, C, Holstege, H, Vilas, R, Hulsman, M, Humphrey, J, Biessels, G, Jian, X, Johansson, C, Jun, G, Kastumata, Y, Kauwe, J, Kehoe, P, Kilander, L, Ståhlbom, A, Kivipelto, M, Koivisto, A, Kornhuber, J, Kosmidis, M, Kukull, W, Kuksa, P, Kunkle, B, Kuzma, A, Lage, C, Laukka, E, Launer, L, Lauria, A, Lee, C, Lehtisalo, J, Lerch, O, Lleó, A, Longstreth, W, Lopez, O, de Munain, A, Love, S, Löwemark, M, Luckcuck, L, Lunetta, K, Ma, Y, Macías, J, Macleod, C, Maier, W, Mangialasche, F, Spallazzi, M, Marquié, M, Marshall, R, Martin, E, Montes, A, Rodríguez, C, Masullo, C, Mayeux, R, Mead, S, Mecocci, P, Medina, M, Meggy, A, Mehrabian, S, Mendoza, S, Menéndez-González, M, Mir, P, Moebus, S, Mol, M, Molina-Porcel, L, Montrreal, L, Morelli, L, Moreno, F, Morgan, K, Mosley, T, Nöthen, M, Muchnik, C, Mukherjee, S, Nacmias, B, Ngandu, T, Nicolas, G, Nordestgaard, B, Olaso, R, Orellana, A, Orsini, M, Ortega, G, Padovani, A, Paolo, C, Papenberg, G, Parnetti, L, Pasquier, F, Pastor, P, Peloso, G, Pérez-Cordón, A, Pérez-Tur, J, Pericard, P, Peters, O, Pijnenburg, Y, Pineda, J, Piñol-Ripoll, G, Pisanu, C, Polak, T, Popp, J, Posthuma, D, Priller, J, Puerta, R, Quenez, O, Quintela, I, Thomassen, J, Rábano, A, Rainero, I, Rajabli, F, Ramakers, I, Real, L, Reinders, M, Reitz, C, Reyes-Dumeyer, D, Ridge, P, Riedel-Heller, S, Riederer, P, Roberto, N, Rodriguez-Rodriguez, E, Rongve, A, Allende, I, Rosende-Roca, M, Royo, J, Rubino, E, Rujescu, D, Sáez, M, Sakka, P, Saltvedt, I, Sanabria, Á, Sánchez-Arjona, M, Sanchez-Garcia, F, Juan, P, Sánchez-Valle, R, Sando, S, Sarnowski, C, Satizabal, C, Scamosci, M, Scarmeas, N, Scarpini, E, Scheltens, P, Scherbaum, N, Scherer, M, Schmid, M, Schneider, A, Schott, J, Selbæk, G, Seripa, D, Serrano, M, Sha, J, Shadrin, A, Skrobot, O, Slifer, S, Snijders, G, Soininen, H, Solfrizzi, V, Solomon, A, Song, Y, Sorbi, S, Sotolongo-Grau, O, Spalletta, G, Spottke, A, Squassina, A, Stordal, E, Tartan, J, Tárraga, L, Tesí, N, Thalamuthu, A, Thomas, T, Tosto, G, Traykov, L, Tremolizzo, L, Tybjærg-Hansen, A, 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Spec Psychiatrie (9), UAM. Departamento de Biología Molecular, University of Helsinki, Department of Neurosciences, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, HUS Neurocenter, Neurologian yksikkö, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (France), European Commission, LabEx DISTALZ, Pérez-Tur, Jordi, University Children’s Hospital Basel (Suiza), INSERM (Francia), Lille Métropole Communauté Urbaine, Government of France (Francia), EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Holmans, Peter A. [0000-0003-0870-9412], van der Lee, Sven J. [0000-0003-1606-8643], Costa, Marcos R. [0000-0002-4928-2163], Bis, Joshua C. [0000-0002-3409-1110], Brookes, Keeley J. [0000-0003-2427-2513], Bush, William S. [0000-0002-9729-6519], de Witte, Lot D. [0000-0002-7235-9958], del Ser, Teodoro [0000-0001-9806-7083], Fox, Nick C. 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[0000-0001-8766-6224], and Molecular Neuroscience and Ageing Research (MOLAR)

Subjects
tau Proteins/genetics, Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1], Neurologi, MED/03 - GENETICA MEDICA, 45/43, Medizin, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], genetics [Alzheimer Disease], Genome-Wide Association Study, Humans, tau Proteins, Alzheimer Disease, Cognitive Dysfunction, VARIANTS, pathology [Alzheimer Disease], Tau Proteins, Settore BIO/13 - Biologia Applicata, Cognitive Dysfunction/psychology, 692/699/375/365/1283, IMPUTATION, article, 1184 Genetics, developmental biology, physiology, Biología y Biomedicina / Biología, AMYLOID-BETA, Settore MED/26 - NEUROLOGIA, Neurology, psychology [Cognitive Dysfunction], Medical Genetics, Human, Neuroscience(all), 631/208/205/2138, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, ddc:570, Genetics, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, METAANALYSIS, Medicinsk genetik, MED/26 - NEUROLOGIA, Alzheimer Disease/genetics, neurology, tau Protein, NECROSIS-FACTOR-ALPHA, RISK LOCI, genetics [tau Proteins], PREDICTION MODELS, Human medicine, GENERATION, RESPONSES
Abstract

25 páginas, 6 figuras, 2 tablas, Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele., This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Full consortium acknowledgements and funding are in the Supplementary Not

Published
2022
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19. Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Author

Mazzi, S., Garcia, J., Zarzoso, D., Kazakov, Y., Ongena, J., Dreval, M., Nocente, M., Stancar, Z., Szepesi, G., Eriksson, J., Sahlberg, A., Benkadda, S., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sunden, E., Andrew, P., Angelini, B., Angioni, C., Antoniou, I., Appel, L., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V., Banks, J., Baranov, Y., Barcellona, C., Barnard, A., Barnard, M., Barnsley, R., Barth, A., Baruzzo, M., Barwell, S., Bassan, M., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P., Beckett, D., Begolli, A., Beidler, M., Bekris, N., Beldishevski, M., Belli, E., Belli, F., Belonohy, E., Ben Yaala, M., Benayas, J., Bentley, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Betar, H., Beurskens, M., Bickerton, S., Bieg, B., Bielecki, J., Bierwage, A., Biewer, T., Bilato, R., Bílkova, P., Birkenmeier, G., Bishop, H., Bizarro, J., Blackburn, J., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonfiglio, D., Bonnin, X., Bonofiglo, P., Boocock, S., Booth, A., Booth, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Boyd, K., Bozicevic Mihalic, I., Bradnam, S., Braic, V., Brandt, L., Bravanec, R., Breizman, B., Brett, A., Brezinsek, S., Brix, M., Bromley, K., Brown, B., Brunetti, D., Buckingham, 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moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Swiss Plasma Center (SPC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory for Plasma Physics (LPP), Ecole Royale Militaire / Koninklijke Militaire School (ERM KMS), Kharkiv Institute of Physics and Technology (Ukraine), V.N. Karazin Kharkiv National University (KhNU), Dipartimento di Fisica (Milano), Università degli Studi di Milano = University of Milan (UNIMI), Consiglio Nazionale delle Ricerche [Milano] (CNR), Jozef Stefan Institute [Ljubljana] (IJS), Culham Centre for Fusion Energy (CCFE), Department of Physics and Astronomy [Uppsala], Uppsala University, This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under Grant agreement No 633053., Mazzi, S, Garcia, J, Zarzoso, D, Kazakov, Y, Ongena, J, Dreval, M, Nocente, M, Stancar, Z, Szepesi, G, Eriksson, J, Sahlberg, A, Benkadda, S, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, 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K., Zoulias, I., Zwingmann, W., Zychor, I., JET Contributors, Science and Technology of Nuclear Fusion, EIRES Eng. for Sustainable Energy Systems, Magneto-Hydro-Dynamic Stability of Fusion Plasmas, Applied Physics and Science Education, Kazakov, Yo, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, Aalto University, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max Planck Institute for Plasma Physics, KTH Royal Institute of Technology, and Aalto-yliopisto

Subjects
[PHYS]Physics [physics], Settore FIS/01, Settore ING-IND/18 - Fisica dei Reattori Nucleari, General Physics and Astronomy, simulation, magnetically confined plasma, nuclear fusion, tokamaks, turbulence suppression, Plasma, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], confinement, transport, Alpha particles, Fusion reactors, Turbulence, physics
Abstract

openaire: EC/H2020/633053/EU//EUROfusion Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited. Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity.

Published
2022
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20. Disruption prediction with artificial intelligence techniques in tokamak plasmas

Author

Vega, J, Murari, A, Dormido-Canto, S, Ratta, G, Gelfusa, M, Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Bozicevic Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, I, Carvalho, P, Casiraghi, I, Casson, F, Castaldo, C, Catalan, J, Catarino, N, Causa, F, Cavedon, M, Cecconello, M, Challis, C, Chamberlain, B, Chang, C, Chankin, A, Chapman, B, Chernyshova, M, Chiariello, A, Chmielewski, P, Chomiczewska, A, Chone, L, Ciraolo, G, Ciric, D, Citrin, J, Ciupinski, T, Clark, M, Clarkson, R, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Coelho, R, Coenen, J, Coffey, I, Colangeli, A, Colas, L, Collins, C, Collins, J, Collins, S, Conka, D, Conroy, S, Conway, B, Conway, N, Coombs, D, Cooper, P, Cooper, S, Corradino, C, Corrigan, G, Coster, D, Cox, P, Craciunescu, T, Cramp, S, Crapper, C, Craven, D, Craven, R, Esposito, M, Croci, G, Croft, D, Croitoru, A, Crombe, K, Cronin, T, Cruz, N, Crystal, C, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarski, T, Dabirikhah, H, Dal Molin, A, Dale, E, Dalgliesh, P, Dalley, S, Dankowski, J, David, P, Davies, A, Davies, S, Davis, G, Dawson, K, Dawson, S, Day, I, De Bock, M, De Temmerman, G, De Tommasi, G, Deakin, K, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Del-Castillo-Negrete, D, Dempsey, A, Dendy, R, Devynck, P, Di Siena, A, Di Troia, C, Dickson, T, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, R, Donne, A, Dorling, S, Douai, D, Dowson, S, Doyle, R, Dreval, M, Drewelow, P, Drews, P, Drummond, G, Duckworth, P, Dudding, H, Dumont, R, Dumortier, P, Dunai, D, Dunatov, T, Dunne, M, Duran, I, Durodie, F, Dux, R, Dvornova, A, Eastham, R, Edwards, J, Eich, T, Eichorn, A, Eidietis, N, Eksaeva, A, El Haroun, H, Ellwood, G, Elsmore, C, Embreus, O, Emery, S, Ericsson, G, Eriksson, B, Eriksson, F, Eriksson, J, Eriksson, L, Ertmer, S, Esquembri, S, Esquisabel, A, Estrada, T, Evans, G, Evans, S, Fable, E, Fagan, D, Faitsch, M, Falessi, M, Fanni, A, Farahani, A, Farquhar, I, Fasoli, A, Faugeras, B, Fazinie, S, Felici, F, Felton, R, Fernandes, A, Fernandes, H, Ferrand, J, Ferreira, D, Ferreira, J, Ferro, G, Fessey, J, Ficker, O, Field, A, Figueiredo, A, Figueiredo, J, Fil, A, Fil, N, Finburg, P, Fiorucci, D, Fischer, U, Fishpool, G, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontana, M, Fontdecaba, J, Forbes, S, Formisano, A, Fornal, T, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Fowler, C, Fransson, E, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fulop, T, Furseman, M, Fusco, V, Futatani, S, Gadariya, D, Gal, K, Galassi, D, Gafezka, K, Galeani, S, Gallart, D, Galvao, R, Gao, Y, Garcia, J, Garcia-Munoz, M, Gardener, M, Garzotti, L, Gaspar, J, Gatto, R, Gaudio, P, Gear, D, Gebhart, T, Gee, S, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Gherendi, M, Ghezzi, F, Giacalone, J, Giacomelli, L, Giacometti, G, Gibson, C, Gibson, K, Gil, L, Gillgren, A, Gin, D, Giovannozzi, E, Giroud, C, Glen, R, Gloggler, S, Goff, J, Gohil, P, Goloborodko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gore, S, Gorini, G, Gorler, T, Gotts, N, Goulding, R, Gow, E, Graham, B, Graves, J, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Gromelski, W, Groth, M, Grove, R, Gruca, M, Guard, D, Gupta, N, Gurl, C, Gusarov, A, Hackett, L, Hacquin, S, Hager, R, Hagg, L, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamaguchi, D, Hamed, M, Hamlyn-Harris, C, Hammond, K, Harford, E, Harrison, J, Harting, D, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hayashi, T, Hazael, S, Hazel, S, Heesterman, P, Heidbrink, B, Helou, W, Hemming, O, Henderson, S, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hill, J, Hillesheim, J, Hizanidis, K, Hjalmarsson, A, Ho, A, Hobirk, J, Hoenen, O, Hogben, C, Hollingsworth, A, Hollis, S, Hollmann, E, Holzl, M, Homan, B, Hook, M, Hopley, D, Hora:ek, J, Horsley, D, Horsten, N, Horton, A, Horton, L, Horvath, L, Hotchin, S, Howell, R, Hu, Z, Huber, A, Huber, V, Huddleston, T, Huijsmans, G, Huynh, P, Hynes, A, Iliasova, M, Lmrie, D, Lmrisek, M, Lngleby, J, Innocente, P, Bjork, K, Isernia, N, lvanova-Stanik, I, Lvings, E, Jablonski, S, Jachmich, S, Jackson, T, Jacquet, P, Jarleblad, H, Jaulmes, F, Rodriguez, J, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Jones, C, Jones, G, Jones, L, Jones, N, Jones, T, Joyce, A, Juarez, R, Juvonen, M, Kalnina, P, Kaltiaisenaho, T, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kashchuk, Y, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Kelly, R, Kempenaars, M, Kennedy, C, Kennedy, D, Kent, J, Khan, K, Khilkevich, E, Kiefer, C, Kilpelainen, J, Kim, C, Kim, H, Kim, S, King, D, King, R, Kinna, D, Kiptily, V, Kirjasuo, A, Kirov, K, Kirschner, A, Kiviniemi, T, Kizane, G, Klas, M, Klepper, C, Klix, A, Kneale, G, Knight, M, Knight, P, Knights, R, Knipe, S, Knolker, M, Knott, S, Kocan, M, Kochl, F, Kodeli, I, Kolesnichenko, Y, Kominis, Y, Kong, M, Korovin, V, Kos, B, Kos, D, Koslowski, H, Kotschenreuther, M, Koubiti, M, Kowalska-Strzeciwilk, E, Koziol, K, Krasilnikov, A, Krasilnikov, V, Kresina, M, Krieger, K, Krishnan, N, Krivska, A, Kruezi, U, Ksiezek, I, Kukushkin, A, Kumpulainen, H, Kurki-Suonio, T, Kurotaki, H, Kwak, S, Kwon, O, Laguardia, L, Lagzdina, E, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, B, Lane, C, Neto, E, Laszyriska, E, Lawson, K, Lazaros, A, Lazzaro, E, Learoyd, G, Lee, C, Lee, S, Leerink, S, Leeson, T, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Gutierrez, E, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lewis, J, Leysen, W, Li, L, Li, Y, Likonen, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Litherland-Smith, E, Liu, F, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lopez, J, Lorenzini, R, Loreti, S, Losada, U, Loschiavo, V, Loughlin, M, Louka, Z, Lovell, J, Lowe, T, Lowry, C, Lubbad, S, Luce, T, Lucock, R, Lukin, A, Luna, C, de la Luna, E, Lungaroni, M, Lungu, C, Lunt, T, Lutsenko, V, Lyons, B, Lyssoivan, A, Machielsen, M, Macusova, E, Maenpaa, R, Maggi, C, Maggiora, R, Magness, M, Mahesan, S, Maier, H, Maingi, R, Malinowski, K, Manas, P, Mantica, P, Mantsinen, M, Manyer, J, Manzanares, A, Maquet, P, Marceca, G, Marcenko, N, Marchetto, C, Marchuk, O, Mariani, A, Mariano, G, Marin, M, Marinelli, M, Markovic, T, Marocco, D, Marot, L, Marsden, S, Marsh, J, Marshall, R, Martellucci, L, Martin, A, Martone, R, Maruyama, S, Maslov, M, Masuzaki, S, Matejcik, S, Mattei, M, Matthews, G, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, Mayer, M, Mayoral, M, Mazzi, S, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mcclenaghan, J, Mccullen, P, Mcdonald, D, Mcguckin, D, Mchugh, D, Mclntyre, G, Mckean, R, Mckehon, J, Mcmillan, B, Mcnamee, L, Mcshee, A, Meakins, A, Medley, S, Meekes, C, Meghani, K, Meigs, A, Meisl, G, Meitner, S, Menmuir, S, Mergia, K, Merriman, S, Mertens, P, Meshchaninov, S, Messiaen, A, Michling, R, Middleton, P, Middleton-Gear, D, Mietelski, J, Milanesio, D, Milani, E, Militello, F, Asp, A, Milnes, J, Milocco, A, Miloshevsky, G, Minghao, C, Minucci, S, Miron, I, Miyamoto, M, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moody, T, Moon, S, Mooney, R, Moradi, S, Morales, J, Morales, R, Mordijck, S, Moreira, L, Morgan, L, Moro, F, Morris, J, Morrison, K, Moser, L, Moulton, D, Mrowetz, T, Mundy, T, Muraglia, M, Muraro, A, Muthusonai, N, N'Konga, B, Na, Y, Nabais, F, Naden, M, Naish, J, Naish, R, Napoli, F, Nardon, E, Naulin, V, Nave, M, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nestoras, I, Neu, R, Neverov, V, Ng, S, Nicassio, M, Nielsen, A, Nina, D, Nishijima, D, Noble, C, Nobs, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, J, Nowak, S, Nunn, E, Nystrom, H, Oberparleiter, M, Obryk, B, O'Callaghan, J, Odupitan, T, Oliver, H, Olney, R, O'Mullane, M, Ongena, J, Organ, E, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Otsuka, T, Owen, A, Oya, Y, Oyaizu, M, Paccagnella, R, Pace, N, Packer, L, Paige, S, Pajuste, E, Palade, D, Pamela, S, Panadero, N, Panontin, E, Papadopoulos, A, Papp, G, Papp, P, Parail, V, Pardanaud, C, Parisi, J, Diaz, F, Parsloe, A, Parsons, M, Parsons, N, Passeri, M, Patel, A, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, C, Peacock, A, Pearce, M, Peluso, E, Penot, C, Pepperell, K, Pereira, R, Pereira, T, Cippo, E, Pereslavtsev, P, Perez von Thun, C, Pericoli, V, Perry, D, Peterka, M, Petersson, P, Petravich, G, Petrella, N, Peyman, M, Pillon, M, Pinches, S, Pintsuk, G, Pires de Sa, W, Pires dos Reis, A, Piron, C, Piron, L, Pironti, A, Pitts, R, van de Plassche, K, Platt, N, Plyusnin, V, Podesta, M, Pokol, G, Poli, F, Pompilian, O, Popovichev, S, Poradzinski, M, Porfiri, M, Porkolab, M, Porosnicu, C, Porton, M, Poulipoulis, G, Predebon, I, Prestopino, G, Price, C, Price, D, Price, M, Primetzhofer, D, Prior, P, Provatas, G, Pucella, G, Puglia, P, Purahoo, K, Pusztai, I, Putignano, O, Putterich, T, Quercia, A, Rachlew, E, Radulescu, G, Radulovic, V, Rainford, M, Raj, P, Ralph, G, Ramogida, G, Rasmussen, D, Rasmussen, J, Ratynskaia, S, Rebai, M, Refy, D, Reichle, R, Reinke, M, Reiser, D, Reux, C, Reynolds, S, Richiusa, M, Richyal, S, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Ramos, M, Rodriguez-Fernandez, P, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rossi, R, Rowe, S, Rowlands, D, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruiz, J, Ruset, C, Rzadkiewicz, J, Saarelma, S, Safi, E, Sahlberg, A, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Sanders, I, Sandiford, D, Santos, B, Santucci, A, Sarkimaki, K, Sarwar, R, Sarychev, I, Sauter, O, Sauwan, P, Scapin, N, Schluck, F, Schmid, K, Schmuck, S, Schneider, M, Schneider, P, Schworer, D, Scott, G, Scott, M, Scraggs, D, Scully, S, Segato, M, Seo, J, Sergienko, G, Sertoli, M, Sharapov, S, Shaw, A, Sheikh, H, Sheikh, U, Shepherd, A, Shevelev, A, Shigin, P, Shinohara, K, Shiraiwa, S, Shiraki, D, Short, M, Sias, G, Silburn, S, Silva, A, Silva, C, Silva, J, Silvagni, D, Simfukwe, D, Simpson, J, Sinclair, D, Sipila, S, Sips, A, Siren, P, Sirinelli, A, Sjostrand, H, Skinner, N, Slater, J, Smith, N, Smith, P, Snell, J, Snoep, G, Snoj, L, Snyder, P, Soare, S, Solano, E, Solokha, V, Somers, A, Sommariva, C, Soni, K, Sorokovoy, E, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Spelzini, T, Spineanu, F, Spong, D, Sprada, D, Sridhar, S, Srinivasan, C, Stables, G, Staebler, G, Stamatelatos, I, Stancar, Z, Staniec, P, Stankunas, G, Stead, M, Stefanikova, E, Stephen, A, Stephens, J, Stevenson, P, Stojanov, M, Strand, P, Strauss, H, Strikwerda, S, Strom, P, Stuart, C, Studholme, W, Subramani, M, Suchkov, E, Sumida, S, Sun, H, Susts, T, Svensson, J, Svoboda, J, Sweeney, R, Sytnykov, D, Szabolics, T, Szepesi, G, Tabia, B, Tadic, T, Tal, B, Tala, T, Tallargio, A, Tamain, P, Tan, H, Tanaka, K, Tang, W, Tardocchi, M, Taylor, D, Teimane, A, Telesca, G, Teplova, N, Teplukhina, A, Terentyev, D, Terra, A, Terranova, D, Terranova, N, Testa, D, Tholerus, E, Thomas, J, Thoren, E, Thorman, A, Tierens, W, Tinguely, R, Tipton, A, Todd, H, Tokitani, M, Tolias, P, Tomes, M, Tookey, A, Torikai, Y, von Toussaint, U, Tsavalas, P, Tskhakaya, D, Turner, I, Turner, M, Turnyanskiy, M, Tvalashvili, G, Tyrrell, S, Tyshchenko, M, Uccello, A, Udintsev, V, Urbanczyk, G, Vadgama, A, Valcarcel, D, Valisa, M, Olivares, P, Vallhagen, O, Valovic, M, Eester, D, Varje, J, Vartanian, S, Vasilopoulou, T, Vayakis, G, Vecsei, M, Ventre, S, Verdoolaege, G, Verona, C, Rinati, G, Veshchev, E, Vianello, N, Viezzer, E, Vignitchouk, L, Vila, R, Villari, R, Villone, F, Vincenzi, P, Vinyar, I, Viola, B, Virtanen, A, Vitins, A, Vizvary, Z, Vlad, G, Vlad, M, Vondracek, P, de Vries, P, Wakeling, B, Walkden, N, Walker, M, Walker, R, Walsh, M, Wang, E, Wang, N, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Weckmann, A, Maxwell, H, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, Wendler, N, West, A, Wheatley, M, Wheeler, S, Whitehead, A, Whittaker, D, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Willoughby, D, Wilson, I, Wilson, J, Wilson, T, Wischmeier, M, Wise, P, Withenshaw, G, Withycombe, A, Witts, D, Wojcik-Gargula, A, Wolfrum, E, Wood, R, Woodley, C, Woodley, R, Woods, B, Wright, J, Xu, T, Yadikin, D, Yajima, M, Yakovenko, Y, Yang, Y, Yanling, W, Yanovskiy, V, Young, I, Young, R, Zabolockis, R, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zarins, A, Fernandez, D, Zastrow, K, Zayachuk, Y, Zerbini, M, Zhang, W, Zhou, Y, Zlobinski, M, Zocco, A, Zohar, A, Zoita, V, Zoletnik, S, Zotta, V, Zoulias, I, Zwingmann, W, Zychor, I, Vega J., Murari A., Dormido-Canto S., Ratta G. A., Gelfusa M., Mailloux J., Abid N., Abraham K., Abreu P., Adabonyan O., Adrich P., Afanasev V., Afzal M., Ahlgren T., Aho-Mantila L., Aiba N., Airila M., Akhtar M., Albanese R., Alderson-Martin M., Alegre D., Aleiferis S., Aleksa A., Alekseev A. G., Alessi E., Aleynikov P., Algualcil J., Ali M., Allinson M., Alper B., Alves E., Ambrosino G., Ambrosino R., Amosov V., Sunden E. A., Andrew P., Angelini B. M., Angioni C., Antoniou I., Appel L. C., Appelbee C., Aria S., Ariola M., Artaserse G., Arter W., Artigues V., Asakura N., Ash A., Ashikawa N., Aslanyan V., Astrain M., Asztalos O., Auld D., Auriemma F., Austin Y., Avotina L., Aymerich E., Baciero A., Bairaktaris F., Balbin J., Balbinot L., Balboa I., Balden M., Balshaw C., Balshaw N., Bandaru V. K., Banks J., Baranov Y. F., Barcellona C., Barnard A., Barnard M., Barnsley R., Barth A., Baruzzo M., Barwell S., Bassan M., Batista A., Batistoni P., Baumane L., Bauvir B., Baylor L., Beaumont P. S., Beckett D., Begolli A., Beidler M., Bekris N., Beldishevski M., Belli E., Belli F., Belonohy E., Yaala M. B., Benayas J., Bentley J., Bergsaker H., Bernardo J., Bernert M., Berry M., Bertalot L., Betar H., Beurskens M., Bickerton S., Bieg B., Bielecki J., Bierwage A., Biewer T., Bilato R., Bilkova P., Birkenmeier G., Bishop H., Bizarro J. P. S., Blackburn J., Blanchard P., Blatchford P., Bobkov V., Boboc A., Bohm P., Bohm T., Bolshakova I., Bolzonella T., Bonanomi N., Bonfiglio D., Bonnin X., Bonofiglo P., Boocock S., Booth A., Booth J., Borba D., Borodin D., Borodkina I., Boulbe C., Bourdelle C., Bowden M., Boyd K., Bozicevic Mihalic I., Bradnam S. C., Braic V., Brandt L., Bravanec R., Breizman B., Brett A., Brezinsek S., Brix M., Bromley K., Brown B., Brunetti D., Buckingham R., Buckley M., Budny R., Buermans J., Bufferand H., Buratti P., Burgess A., Buscarino A., Busse A., Butcher D., de la Cal E., Calabro G., Calacci L., Calado R., Camenen Y., Canal G., Cannas B., Cappelli M., Carcangiu S., Card P., Cardinali A., Carman P., Carnevale D., Carr M., Carralero D., Carraro L., Carvalho I. S., Carvalho P., Casiraghi I., Casson F. J., Castaldo C., Catalan J. P., Catarino N., Causa F., Cavedon M., Cecconello M., Challis C. D., Chamberlain B., Chang C. S., Chankin A., Chapman B., Chernyshova M., Chiariello A., Chmielewski P., Chomiczewska A., Chone L., Ciraolo G., Ciric D., Citrin J., Ciupinski T., Clark M., Clarkson R., Clements C., Cleverly M., Coad J. P., Coates P., Cobalt A., Coccorese V., Coelho R., Coenen J. W., Coffey I. H., Colangeli A., Colas L., Collins C., Collins J., Collins S., Conka D., Conroy S., Conway B., Conway N. J., Coombs D., Cooper P., Cooper S., Corradino C., Corrigan G., Coster D., Cox P., Craciunescu T., Cramp S., Crapper C., Craven D., Craven R., Esposito M. C., Croci G., Croft D., Croitoru A., Crombe K., Cronin T., Cruz N., Crystal C., Cseh G., Cufar A., Cullen A., Curuia M., Czarski T., Dabirikhah H., Dal Molin A., Dale E., Dalgliesh P., Dalley S., Dankowski J., David P., Davies A., Davies S., Davis G., Dawson K., Dawson S., Day I. E., De Bock M., De Temmerman G., De Tommasi G., Deakin K., Deane J., Dejarnac R., Del Sarto D., Delabie E., Del-Castillo-Negrete D., Dempsey A., Dendy R. O., Devynck P., Di Siena A., Di Troia C., Dickson T., Dinca P., Dittmar T., Dobrashian J., Doerner R. P., Donne A. J. 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A., Huynh P., Hynes A., Iliasova M., lmrie D., lmrisek M., lngleby J., Innocente P., Bjork K. I., Isernia N., lvanova-Stanik I., lvings E., Jablonski S., Jachmich S., Jackson T., Jacquet P., Jarleblad H., Jaulmes F., Rodriguez J. J., Jepu I., Joffrin E., Johnson R., Johnson T., Johnston J., Jones C., Jones G., Jones L., Jones N., Jones T., Joyce A., Juarez R., Juvonen M., Kalnina P., Kaltiaisenaho T., Kaniewski J., Kantor A., Kappatou A., Karhunen J., Karkinsky D., Kashchuk Y., Kaufman M., Kaveney G., Kazakov Y. E. O., Kazantzidis V., Keeling D. L., Kelly R., Kempenaars M., Kennedy C., Kennedy D., Kent J., Khan K., Khilkevich E., Kiefer C., Kilpelainen J., Kim C., Kim H. -T., Kim S. H., King D. B., King R., Kinna D., Kiptily V. G., Kirjasuo A., Kirov K. K., Kirschner A., kiviniemi T., Kizane G., Klas M., Klepper C., Klix A., Kneale G., Knight M., Knight P., Knights R., Knipe S., Knolker M., Knott S., Kocan M., Kochl F., Kodeli I., Kolesnichenko Y., Kominis Y., Kong M., Korovin V., Kos B., Kos D., Koslowski H. R., Kotschenreuther M., Koubiti M., Kowalska-Strzeciwilk E., Koziol K., Krasilnikov A., Krasilnikov V., Kresina M., Krieger K., Krishnan N., Krivska A., Kruezi U., Ksiezek I., Kukushkin A. B., Kumpulainen H., Kurki-Suonio T., Kurotaki H., Kwak S., Kwon O. J., Laguardia L., Lagzdina E., Lahtinen A., Laing A., Lam N., Lambertz H. T., Lane B., Lane C., Neto E. L., Laszyriska E., Lawson K. D., Lazaros A., Lazzaro E., Learoyd G., Lee C., Lee S. E., Leerink S., Leeson T., Lefebvre X., Leggate H. J., Lehmann J., Lehnen M., Leichtle D., Leipold F., Lengar I., Lennholm M., Gutierrez E. 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F., Matveev D., Matveeva E., Mauriya A., Maviglia F., Mayer M., Mayoral M. -L., Mazzi S., Mazzotta C., McAdams R., McCarthy P. J., McClements K. G., McClenaghan J., McCullen P., McDonald D. C., McGuckin D., McHugh D., Mclntyre G., McKean R., McKehon J., McMillan B., McNamee L., McShee A., Meakins A., Medley S., Meekes C. J., Meghani K., Meigs A. G., Meisl G., Meitner S., Menmuir S., Mergia K., Merriman S., Mertens P., Meshchaninov S., Messiaen A., Michling R., Middleton P., Middleton-Gear D., Mietelski J., Milanesio D., Milani E., Militello F., Asp A. M., Milnes J., Milocco A., Miloshevsky G., Minghao C., Minucci S., Miron I., Miyamoto M., Mlynar J., Moiseenko V., Monaghan P., Monakhov I., Moody T., Moon S., Mooney R., Moradi S., Morales J., Morales R. 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Abstract

In nuclear fusion reactors, plasmas are heated to very high temperatures of more than 100 million kelvin and, in so-called tokamaks, they are confined by magnetic fields in the shape of a torus. Light nuclei, such as deuterium and tritium, undergo a fusion reaction that releases energy, making fusion a promising option for a sustainable and clean energy source. Tokamak plasmas, however, are prone to disruptions as a result of a sudden collapse of the system terminating the fusion reactions. As disruptions lead to an abrupt loss of confinement, they can cause irreversible damage to present-day fusion devices and are expected to have a more devastating effect in future devices. Disruptions expected in the next-generation tokamak, ITER, for example, could cause electromagnetic forces larger than the weight of an Airbus A380. Furthermore, the thermal loads in such an event could exceed the melting threshold of the most resistant state-of-the-art materials by more than an order of magnitude. To prevent disruptions or at least mitigate their detrimental effects, empirical models obtained with artificial intelligence methods, of which an overview is given here, are commonly employed to predict their occurrence—and ideally give enough time to introduce counteracting measures.

Published
2022

21. Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Author

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R., Ruset C., Rzadkiewicz J., Saarelma S., Safi E., Salewski M., Salmi A., Salmon R., Salzedas F., Sanders I., Sandiford D., Santos B., Santucci A., Sarkimaki K., Sarwar R., Sarychev I., Sauter O., Sauwan P., Scapin N., Schluck F., Schmid K., Schmuck S., Schneider M., Schneider P. A., Schworer D., Scott G., Scott M., Scraggs D., Scully S., Segato M., Seo J., Sergienko G., Sertoli M., Sharapov S. E., Shaw A., Sheikh H., Sheikh U., Shepherd A., Shigin P., Shinohara K., Shiraiwa S., Shiraki D., Short M., Sias G., Silburn S. A., Silva A., Silva C., Silva J., Silvagni D., Simfukwe D., Simpson J., Sinclair D., Sipila S. K., Sips A. C. C., Siren P., Sirinelli A., Sjostrand H., Skinner N., Slater J., Smith N., Smith P., Snell J., Snoep G., Snoj L., Snyder P., Soare S., Solano E. 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M., Turnyanskiy M., Tvalashvili G., Tyrrell S., Tyshchenko M., Uccello A., Udintsev V., Urbanczyk G., Vadgama A., Valcarcel D., Valisa M., Vallejos Olivares P., Vallhagen O., Valovic M., Van Eester D., Varje J., Vartanian S., Vasilopoulou T., Vayakis G., Vecsei M., Vega J., Ventre S., Verdoolaege G., Verona C., Rinati G. V., Veshchev E., Vianello N., Viezzer E., Vignitchouk L., Vila R., Villari R., Villone F., Vincenzi P., Viola B., Virtanen A. J., Vitins A., Vizvary Z., Vlad G., Vlad M., Vondracek P., de Vries P., Wakeling B., Walkden N. R., Walker M., Walker R., Walsh M., Wang E., Wang N., Warder S., Warren R., Waterhouse J., Watts C., Wauters T., Weckmann A., Wedderburn Maxwell H., Weiland M., Weisen H., Weiszflog M., Welch P., Wendler N., West A., Wheatley M., Wheeler S., Whitehead A., Whittaker D., Widdowson A., Wiesen S., Wilkinson J., Williams J. 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R., Kotschenreuther M., Koubiti M., Kowalska-Strzeciwilk E., Koziol K., Krasilnikov V., Kresina M., Krieger K., Krishnan N., Krivska A., Kruezi U., Ksiazek I., Kukushkin A. B., Kumpulainen H., Kurki-Suonio T., Kurotaki H., Kwak S., Kwon O. J., Laguardia L., Lagzdina E., Lahtinen A., Laing A., Lam N., Lambertz H. T., Lane B., Lane C., Lascas Neto E., Laszynska E., Lawson K. D., Lazaros A., Lazzaro E., Learoyd G., Lee C., Lee S. E., Leerink S., Leeson T., Lefebvre X., Leggate H. J., Lehmann J., Lehnen M., Leichtle D., Leipold F., Lengar I., Lennholm M., Leon Gutierrez E., Lepiavko B., Leppanen J., Lerche E., Lescinskis A., Lewis J., Leysen W., Li L., Li Y., Likonen J., Linsmeier C., Lipschultz B., Litaudon X., Litherland-Smith E., Liu F., Loarer T., Loarte A., Lobel R., Lomanowski B., Lomas P. J., Lopez J. M., Lorenzini R., Loreti S., Losada U., Loschiavo V. P., Loughlin M., Louka Z., Lovell J., Lowe T., Lowry C., Lubbad S., Luce T., Lucock R., Luna C., de la Luna E., Lungaroni M., Lungu C. P., Lunt T., Lutsenko V., Lyons B., Lyssoivan A., Machielsen M., Macusova E., Maenpaa R., Maggi C. F., Maggiora R., Magness M., Mahesan S., Maier H., Mailloux J., Maingi R., Malinowski K., Manas P., Mantica P., Mantsinen M. J., Manyer J., Manzanares A., Maquet P., Marceca G., Marchetto C., Marchuk O., Mariani A., Mariano G., Marin M., Marinelli M., Markovic T., Marocco D., Marot L., Marsden S., Marsh J., Marshall R., Martellucci L., Martin A., Martin A. J., Martone R., Maruyama S., Maslov M., Masuzaki S., Matejcik S., Mattei M., Matthews G. F., Matveev D., Matveeva E., Mauriya A., Maviglia F., Mayer M., Mayoral M. -L., Mazzotta C., McAdams R., McCarthy P. J., McClements K. G., McClenaghan J., McCullen P., McDonald D. C., McGuckin D., McHugh D., McIntyre G., McKean R., McKehon J., McMillan B., McNamee L., McShee A., Meakins A., Medley S., Meekes C. J., Meghani K., Meigs A. G., Meisl G., Meitner S., Menmuir S., Mergia K., Merriman S., Mertens P., Messiaen A., Michling R., Middleton P., Middleton-Gear D., Mietelski J., Milanesio D., Milani E., Militello F., Militello Asp A., Milnes J., Milocco A., Miloshevsky G., Minghao C., Minucci S., Miron I., Miyamoto M., Mlynar J., Moiseenko V., Monaghan P., Monakhov I., Moody T., Moon S., Mooney R., Moradi S., Morales J., Morales R. B., Mordijck S., Moreira L., Morgan L., Moro F., Morris J., Morrison K. -M., Moser L., Moulton D., Mrowetz T., Mundy T., Muraglia M., Murari A., Muraro A., Muthusonai N., N'Konga B., Na Y. -S., Nabais F., Naden M., Naish J., Naish R., Napoli F., Nardon E., Naulin V., Nave M. F. F., Nedzelskiy I., Nestoras I., Neu R., Ng S., Nicassio M., Nielsen A. H., Nina D., Nishijima D., Noble C., Nobs C. R., Nodwell D., Nordlund K., Nordman H., Normanton R., Noterdaeme J. -M., Nowak S., Nunn E., Nystrom H., Oberparleiter M., Obryk B., O'Callaghan J., Odupitan T., Oliver H. J. 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M., Turnyanskiy M., Tvalashvili G., Tyrrell S., Tyshchenko M., Uccello A., Udintsev V., Urbanczyk G., Vadgama A., Valcarcel D., Valisa M., Vallejos Olivares P., Vallhagen O., Valovic M., Van Eester D., Varje J., Vartanian S., Vasilopoulou T., Vayakis G., Vecsei M., Vega J., Ventre S., Verdoolaege G., Verona C., Rinati G. V., Veshchev E., Vianello N., Viezzer E., Vignitchouk L., Vila R., Villari R., Villone F., Vincenzi P., Viola B., Virtanen A. J., Vitins A., Vizvary Z., Vlad G., Vlad M., Vondracek P., de Vries P., Wakeling B., Walkden N. R., Walker M., Walker R., Walsh M., Wang E., Wang N., Warder S., Warren R., Waterhouse J., Watts C., Wauters T., Weckmann A., Wedderburn Maxwell H., Weiland M., Weisen H., Weiszflog M., Welch P., Wendler N., West A., Wheatley M., Wheeler S., Whitehead A., Whittaker D., Widdowson A., Wiesen S., Wilkinson J., Williams J. C., Willoughby D., Wilson I., Wilson J., Wilson T., Wischmeier M., Wise P., Withenshaw G., Withycombe A., Witts D., Wojcik-Gargula A., Wolfrum E., Wood R., Woodley C., Woodley R., Woods B., Wright J., Wright J. C., Xu T., Yadikin D., Yajima M., Yakovenko Y., Yang Y., Yanling W., Yanovskiy V., Young I., Young R., Zabolockis R. J., Zacks J., Zagorski R., Zaitsev F. S., Zakharov L., Zarins A., Zastrow K. -D., Zayachuk Y., Zerbini M., Zhang W., Zhou Y., Zlobinski M., Zocco A., Zohar A., Zoita V., Zoletnik S., Zotta V. K., Zoulias I., Zwingmann W., and Zychor I.

Abstract

Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity.

Published
2022

24. Digital life storybooks for people with dementia living in care homes: an evaluation

Author

Subramaniam P and Woods B

Subjects
care homes, dementia, ICT, life story book, reminiscence, Geriatrics, RC952-954.6
Abstract

Ponnusamy Subramaniam,1 Bob Woods2 1Health Psychology Programme, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Dementia Services Development Centre Wales, Bangor University, Bangor, Gwynedd, UK Background and aim: There is increasing interest in using information and communication technology to help older adults with dementia to engage in reminiscence work. Now, the feasibility of such approaches is beginning to be established. The purpose of this study was to establish an evidence-base for the acceptability and efficacy of using multimedia digital life storybooks with people with dementia in care homes, in comparison with conventional life storybooks, taking into account the perspectives of people with dementia, their relatives, and care staff.Methods: Participatory design was used to create a life story movie based on a previously completed conventional life storybook with six older adults with dementia (four females; mean age 82 years). Relatives were involved in helping the participant to provide additional information and materials for the digital life storybook. In this multiple case study design, both quantitative and qualitative approaches were used. For quantitative purposes, a set of questionnaires that had been completed three times before and after the conventional life storybook was developed were repeated 4 weeks after the life story movie was completed. Semistructured interview questions were designed to collect feedback from participants, relatives, and care staff.Results: The result indicated that five of the six participants showed additional improvement in measures of quality of life and autobiographical memory. All participants showed improvement or stability in depression scores. Thematic analysis showed that, participants, relatives, and care home staff viewed digital life storybooks as a very useful tool triggering memories and (largely) positive emotions. Participants’ case vignettes were presented to document the impact of digital life storybook. Keywords: care homes, dementia, ICT, life storybook, reminiscence

Published
2016

26. sj-docx-1-mpp-10.1177_23814683231152885 – Supplemental material for Developing a Modeling Framework for Quantifying the Health and Cost Implications of Antibiotic Resistance for Surgical Procedures

Author

Davies, Heather, Russell, Joel, Varghese, Angel, Holmes, Hayden, Soares, Marta O., Woods, B., Puig-Peiro, Ruth, Evans, Stephanie, Tierney, Rory, Mealing, Stuart, Sculpher, Mark, and Robotham, Julie V.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-mpp-10.1177_23814683231152885 for Developing a Modeling Framework for Quantifying the Health and Cost Implications of Antibiotic Resistance for Surgical Procedures by Heather Davies, Joel Russell, Angel Varghese, Hayden Holmes, Marta O. Soares, B. Woods, Ruth Puig-Peiro, Stephanie Evans, Rory Tierney, Stuart Mealing, Mark Sculpher and Julie V. Robotham in MDM Policy & Practice

Published
2023
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29. Disruption prediction with artificial intelligence techniques in tokamak plasmas

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Vega, J., Murari, A., Dormido-Canto, S., Rattá, G. A., Gelfusa, M., Mailloux, J., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A. G., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sundén, E., Andrew, P., Angelini, B. M., Angioni, C., Antoniou, I., Appel, L. C., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Yu. F., Barcellona, C., Barnard, A., Barnard, M., Barnsley, R., Barth, A., Baruzzo, M., Barwell, S., Bassan, M., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckett, D., Begolli, A., Beidler, M., Bekris, N., Beldishevski, M., Belli, E., Belli, F., Belonohy, É., Ben Yaala, M., Benayas, J., Bentley, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Betar, H., Beurskens, M., Bickerton, S., Bieg, B., Bielecki, J., Bierwage, A., Biewer, T., Bilato, R., Bílková, P., Birkenmeier, G., Bishop, H., Bizarro, J. P. S., Blackburn, J., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonfiglio, D., Bonnin, X., Bonofiglo, P., Boocock, S., Booth, A., Booth, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Boyd, K., Božičević Mihalić, I., Bradnam, S. C., Braic, V., Brandt, L., Bravanec, R., Breizman, B., Brett, A., Brezinsek, S., Brix, M., Bromley, K., Brown, B., Brunetti, D., Buckingham, R., Buckley, M., Budny, R., Buermans, J., Bufferand, H., Buratti, P., Burgess, A., Buscarino, A., Busse, A., Butcher, D., de la Cal, E., Calabro, G., Calacci, L., Calado, R., Camenen, Y., Canal, G., Cannas, B., Cappelli, M., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, I. S., Carvalho, P., Casiraghi, I., Casson, F. J., Castaldo, C., Catalan, J. P., Catarino, N., Causa, F., Cavedon, M., Cecconello, M., Challis, C. D., Chamberlain, B., Chang, C. S., Chankin, A., Chapman, B., Chernyshova, M., Chiariello, A., Chmielewski, P., Chomiczewska, A., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Ciupinski, T., Clark, M., Clarkson, R., Clements, C., Cleverly, M., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V., Coelho, R., Coenen, J. W., Coffey, I. H., Colangeli, A., Colas, L., Collins, C., Collins, J., Collins, S., Conka, D., Conroy, S., Conway, B., Conway, N. J., Coombs, D., Cooper, P., Cooper, S., Corradino, C., Corrigan, G., Coster, D., Cox, P., Craciunescu, T., Cramp, S., Crapper, C., Craven, D., Craven, R., Crialesi Esposito, M., Croci, G., Croft, D., Croitoru, A., Crombé, K., Cronin, T., Cruz, N., Crystal, C., Cseh, G., Cufar, A., Cullen, A., Curuia, M., Czarski, T., Dabirikhah, H., Dal Molin, A., Dale, E., Dalgliesh, P., Dalley, S., Dankowski, J., David, P., Davies, A., Davies, S., Davis, G., Dawson, K., Dawson, S., Day, I. E., De Bock, M., De Temmerman, G., De Tommasi, G., Deakin, K., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Del-Castillo-Negrete, D., Dempsey, A., Dendy, R. O., Devynck, P., Di Siena, A., Di Troia, C., Dickson, T., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R. P., Donné, A. J. H., Dorling, S., Douai, D., Dowson, S., Doyle, R., Dreval, M., Drewelow, P., Drews, P., Drummond, G., Duckworth, Ph., Dudding, H., Dumont, R., Dumortier, P., Dunai, D., Dunatov, T., Dunne, M., Duran, I., Durodié, F., Dux, R., Dvornova, A., Eastham, R., Edwards, J., Eich, Th., Eichorn, A., Eidietis, N., Eksaeva, A., El Haroun, H., Ellwood, G., Elsmore, C., Embreus, O., Emery, S., Ericsson, G., Eriksson, B., Eriksson, F., Eriksson, J., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Estrada, T., Evans, G., Evans, S., Fable, E., Fagan, D., Faitsch, M., Falessi, M., Fanni, A., Farahani, A., Farquhar, I., Fasoli, A., Faugeras, B., Fazinié, S., Felici, F., Felton, R., Fernandes, A., Fernandes, H., Ferrand, J., Ferreira, D. R., Ferreira, J., Ferro, G., Fessey, J., Ficker, O., Field, A. R., Figueiredo, A., Figueiredo, J., Fil, A., Fil, N., Finburg, P., Fiorucci, D., Fischer, U., Fishpool, G., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontana, M., Fontdecaba, J. M., Forbes, S., Formisano, A., Fornal, T., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Fowler, C., Fransson, E., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fülop, T., Furseman, M., Fusco, V., Futatani, S., Gadariya, D., Gál, K., Galassi, D., Gafézka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., García-Muñoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gatto, R., Gaudio, P., Gear, D., Gebhart, T., Gee, S., George, R., Gerasimov, S. N., Gervasini, G., Gethins, M., Ghani, Z., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, C., Gibson, K. J., Gil, L., Gillgren, A., Gin, D., Giovannozzi, E., Giroud, C., Glen, R., Gloggler, S., Goff, J., Gohil, P., Goloborodko, V., Gomes, R., Gonçalves, B., Goniche, M., Goodyear, A., Gore, S., Gorini, G., Gorler, T., Gotts, N., Goulding, R., Gow, E., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Gromelski, W., Groth, M., Grove, R., Gruca, M., Guard, D., Gupta, N., Gurl, C., Gusarov, A., Hackett, L., Hacquin, S., Hager, R., Hagg, L., Hakola, A., Halitovs, M., Hall, S., Hall, S. A., Hallworth-Cook, S., Ham, C. J., Hamaguchi, D., Hamed, M., Hamlyn-Harris, C., Hammond, K., Harford, E., Harrison, J. R., Harting, D., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hayashi, T., Hazael, S., Hazel, S., Heesterman, P., Heidbrink, B., Helou, W., Hemming, O., Henderson, S. S., Henriques, R. B., Hepple, D., Herfindal, J., Hermon, G., Hill, J., Hillesheim, J. C., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hoenen, O., Hogben, C., Hollingsworth, A., Hollis, S., Hollmann, E., Holzl, M., Homan, B., Hook, M., Hopley, D., Horá:ek, J., Horsley, D., Horsten, N., Horton, A., Horton, L. D., Horvath, L., Hotchin, S., Howell, R., Hu, Z., Huber, A., Huber, V., Huddleston, T., Huijsmans, G. T. A., Huynh, P., Hynes, A., Iliasova, M., Lmrie, D., Lmrísek, M., Lngleby, J., Innocente, P., Insulander Björk, K., Isernia, N., lvanova-Stanik, I., Lvings, E., Jablonski, S., Jachmich, S., Jackson, T., Jacquet, P., Järleblad, H., Jaulmes, F., Jenaro Rodriguez, J., Jepu, I., Joffrin, E., Johnson, R., Johnson, T., Johnston, J., Jones, C., Jones, G., Jones, L., Jones, N., Jones, T., Joyce, A., Juarez, R., Juvonen, M., Kalnina, P., Kaltiaisenaho, T., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kashchuk, Yu, Kaufman, M., Kaveney, G., Kazakov, Y. E. O., Kazantzidis, V., Keeling, D. L., Kelly, R., Kempenaars, M., Kennedy, C., Kennedy, D., Kent, J., Khan, K., Khilkevich, E., Kiefer, C., Kilpeläinen, J., Kim, C., Hyun-Tae, Kim, Kim, S. H., King, D. B., King, R., Kinna, D., Kiptily, V. G., Kirjasuo, A., Kirov, K. K., Kirschner, A., Kiviniemi, T., Kizane, G., Klas, M., Klepper, C., Klix, A., Kneale, G., Knight, M., Knight, P., Knights, R., Knipe, S., Knolker, M., Knott, S., Kocan, M., Kochl, F., Kodeli, I., Kolesnichenko, Y., Kominis, Y., Kong, M., Korovin, V., Kos, B., Kos, D., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kowalska-Strzęciwilk, E., Koziol, K., Krasilnikov, A., Krasilnikov, V., Kresina, M., Krieger, K., Krishnan, N., Krivska, A., Kruezi, U., Ksiézek, I., Kukushkin, A. B., Kumpulainen, H., Kurki-Suonio, T., Kurotaki, H., Kwak, S., Kwon, O. J., Laguardia, L., Lagzdina, E., Lahtinen, A., Laing, A., Lam, N., Lambertz, H. T., Lane, B., Lane, C., Lascas Neto, E., Łaszyríska, E., Lawson, K. D., Lazaros, A., Lazzaro, E., Learoyd, G., Chanyoung, Lee, Lee, S. E., Leerink, S., Leeson, T., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichtle, D., Leipold, F., Lengar, I., Lennholm, M., Leon Gutierrez, E., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lewis, J., Leysen, W., Li, L., Li, Y., Likonen, J., Linsmeier, Ch., Lipschultz, B., Litaudon, X., Litherland-Smith, E., Liu, F., Loarer, T., Loarte, A., Lobel, R., Lomanowski, B., Lomas, P. J., López, J. M., Lorenzini, R., Loreti, S., Losada, U., Loschiavo, V. P., Loughlin, M., Louka, Z., Lovell, J., Lowe, T., Lowry, C., Lubbad, S., Luce, T., Lucock, R., Lukin, A., Luna, C., de la Luna, E., Lungaroni, M., Lungu, C. P., Lunt, T., Lutsenko, V., Lyons, B., Lyssoivan, A., Machielsen, M., Macusova, E., Mäenpää, R., Maggi, C. F., Maggiora, R., Magness, M., Mahesan, S., Maier, H., Maingi, R., Malinowski, K., Manas, P., Mantica, P., Mantsinen, M. J., Manyer, J., Manzanares, A., Maquet, Ph., Marceca, G., Marcenko, N., Marchetto, C., Marchuk, O., Mariani, A., Mariano, G., Marin, M., Marinelli, M., Markovič, T., Marocco, D., Marot, L., Marsden, S., Marsh, J., Marshall, R., Martellucci, L., Martin, A., Martin, A. J., Martone, R., Maruyama, S., Maslov, M., Masuzaki, S., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., Mayer, M., Mayoral, M-L., Mazzi, S., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mcclenaghan, J., Mccullen, P., Mcdonald, D. C., Mcguckin, D., Mchugh, D., Mclntyre, G., Mckean, R., Mckehon, J., Mcmillan, B., Mcnamee, L., Mcshee, A., Meakins, A., Medley, S., Meekes, C. J., Meghani, K., Meigs, A. 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R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J. M., Nowak, S., Nunn, E., Nystrom, H., Oberparleiter, M., Obryk, B., O’Callaghan, J., Odupitan, T., Oliver, H. J. C., Olney, R., O’Mullane, M., Ongena, J., Organ, E., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Otsuka, T., Owen, A., Oya, Y., Oyaizu, M., Paccagnella, R., Pace, N., Packer, L. W., Paige, S., Pajuste, E., Palade, D., Pamela, S. J. P., Panadero, N., Panontin, E., Papadopoulos, A., Papp, G., Papp, P., Parail, V. 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T., Porkolab, M., Porosnicu, C., Porton, M., Poulipoulis, G., Predebon, I., Prestopino, G., Price, C., Price, D., Price, M., Primetzhofer, D., Prior, P., Provatas, G., Pucella, G., Puglia, P., Purahoo, K., Pusztai, I., Putignano, O., Pütterich, T., Quercia, A., Rachlew, E., Radulescu, G., Radulovic, V., Rainford, M., Raj, P., Ralph, G., Ramogida, G., Rasmussen, D., Rasmussen, J. J., Rattá, G., Ratynskaia, S., Rebai, M., Réfy, D., Reichle, R., Reinke, M., Reiser, D., Reux, C., Reynolds, S., Richiusa, M. L., Richyal, S., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C. M., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez Ramos, M., Rodriguez-Fernandez, P., Romanelli, F., Romanelli, M., Romanelli, S., Romazanov, J., Rossi, R., Rowe, S., Rowlands, D., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruiz, M., Ruiz Ruiz, J., Ruset, C., Rzadkiewicz, J., Saarelma, S., Safi, E., Sahlberg, A., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Sanders, I., Sandiford, D., Santos, B., Santucci, A., Sarkimaki, K., Sarwar, R., Sarychev, I., Sauter, O., Sauwan, P., Scapin, N., Schluck, F., Schmid, K., Schmuck, S., Schneider, M., Schneider, P. A., Schworer, D., Scott, G., Scott, M., Scraggs, D., Scully, S., Segato, M., Jaemin, Seo, Sergienko, G., Sertoli, M., Sharapov, S. E., Shaw, A., Sheikh, H., Sheikh, U., Shepherd, A., Shevelev, A., Shigin, P., Shinohara, K., Shiraiwa, S., Shiraki, D., Short, M., Sias, G., Silburn, S. A., Silva, A., Silva, C., Silva, J., Silvagni, D., Simfukwe, D., Simpson, J., Sinclair, D., Sipilä, S. K., Sips, A. C. C., Sirén, P., Sirinelli, A., Sjöstrand, H., Skinner, N., Slater, J., Smith, N., Smith, P., Snell, J., Snoep, G., Snoj, L., Snyder, P., Soare, S., Solano, E. R., Solokha, V., Somers, A., Sommariva, C., Soni, K., Sorokovoy, E., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Spelzini, T., Spineanu, F., Spong, D., Sprada, D., Sridhar, S., Srinivasan, C., Stables, G., Staebler, G., Stamatelatos, I., Stancar, Z., Staniec, P., Stankūnas, G., Stead, M., Stefanikova, E., Stephen, A., Stephens, J., Stevenson, P., Stojanov, M., Strand, P., Strauss, H. R., Strikwerda, S., Ström, P., Stuart, C. I., Studholme, W., Subramani, M., Suchkov, E., Sumida, S., Sun, H. J., Susts, T. E., Svensson, J., Svoboda, J., Sweeney, R., Sytnykov, D., Szabolics, T., Szepesi, G., Tabia, B., Tadić, T., Tál, B., Tala, T., Tallargio, A., Tamain, P., Tan, H., Tanaka, K., Tang, W., Tardocchi, M., Taylor, D., Teimane, A. S., Telesca, G., Teplova, N., Teplukhina, A., Terentyev, D., Terra, A., Terranova, D., Terranova, N., Testa, D., Tholerus, E., Thomas, J., Thoren, E., Thorman, A., Tierens, W., Tinguely, R. A., Tipton, A., Todd, H., Tokitani, M., Tolias, P., Tomes, M., Tookey, A., Torikai, Y., von Toussaint, U., Tsavalas, P., Tskhakaya, D., Turner, I., Turner, M., Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyrrell, S., Tyshchenko, M., Uccello, A., Udintsev, V., Urbanczyk, G., Vadgama, A., Valcarcel, D., Valisa, M., Vallejos Olivares, P., Vallhagen, O., Valovič, M., Van Eester, D., Varje, J., Vartanian, S., Vasilopoulou, T., Vayakis, G., Vecsei, M., Ventre, S., Verdoolaege, G., Verona, C., Verona Rinati, G., Veshchev, E., Vianello, N., Viezzer, E., Vignitchouk, L., Vila, R., Villari, R., Villone, F., Vincenzi, P., Vinyar, I., Viola, B., Virtanen, A. J., Vitins, A., Vizvary, Z., Vlad, G., Vlad, M., Vondráček, P., de Vries, P., Wakeling, B., Walkden, N. R., Walker, M., Walker, R., Walsh, M., Wang, E., Wang, N., Warder, S., Warren, R., Waterhouse, J., Watts, C., Wauters, T., Weckmann, A., Wedderburn Maxwell, H., Weiland, M., Weisen, H., Weiszflog, M., Welch, P., Wendler, N., West, A., Wheatley, M., Wheeler, S., Whitehead, A., Whittaker, D., Widdowson, A., Wiesen, S., Wilkinson, J., Williams, J. C., Willoughby, D., Wilson, I., Wilson, J., Wilson, T., Wischmeier, M., Wise, P., Withenshaw, G., Withycombe, A., Witts, D., Wojcik-Gargula, A., Wolfrum, E., Wood, R., Woodley, C., Woodley, R., Woods, B., Wright, J., Wright, J. C., Xu, T., Yadikin, D., Yajima, M., Yakovenko, Y., Yang, Y., Yanling, W., Yanovskiy, V., Young, I., Young, R., Zabolockis, R. J., Zacks, J., Zagorski, R., Zaitsev, F. S., Zakharov, L., Zarins, A., Zarzoso Fernandez, D., Zastrow, K. -D., Zayachuk, Y., Zerbini, M., Zhang, W., Zhou, Y., Zlobinski, M., Zocco, A., Zohar, A., Zoita, V., Zoletnik, S., Zotta, V. K., Zoulias, I., Zwingmann &amp, Zychor, I., Vega, J, Murari, A, Dormido-Canto, S, Ratta, Ga, Gelfusa, M, Chiariello, A, JET Contributors, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, Uppsala University, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, University of Helsinki, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max Planck Institute for Plasma Physics, KTH Royal Institute of Technology, Aalto-yliopisto, Aalto University, Science and Technology of Nuclear Fusion, EIRES Eng. for Sustainable Energy Systems, Magneto-Hydro-Dynamic Stability of Fusion Plasmas, Vega, J., Murari, A., Dormido-Canto, S., Ratta, G. A., Gelfusa, M., Mailloux, J., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A. G., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Sunden, E. A., Andrew, P., Angelini, B. M., Angioni, C., Antoniou, I., Appel, L. C., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. 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Subjects
JET, Settore ING-IND/18 - Fisica dei Reattori Nucleari, General Physics and Astronomy, artificial intellingence, tokamaks, magnetically confined plasma, disruption predictions, tokamak plasmas, nuclear fusion
Abstract

openaire: EC/H2020/633053/EU//EUROfusion Funding Information: This work was partially funded by the Spanish Ministry of Science and Innovation under projects nos. PID2019-108377RB-C31 and PID2019-108377RB-C32. This work has been carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (grant agreement no. 101052200 — EUROfusion). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the European Commission can be held responsible for them. Publisher Copyright: © 2022, Springer Nature Limited. In nuclear fusion reactors, plasmas are heated to very high temperatures of more than 100 million kelvin and, in so-called tokamaks, they are confined by magnetic fields in the shape of a torus. Light nuclei, such as deuterium and tritium, undergo a fusion reaction that releases energy, making fusion a promising option for a sustainable and clean energy source. Tokamak plasmas, however, are prone to disruptions as a result of a sudden collapse of the system terminating the fusion reactions. As disruptions lead to an abrupt loss of confinement, they can cause irreversible damage to present-day fusion devices and are expected to have a more devastating effect in future devices. Disruptions expected in the next-generation tokamak, ITER, for example, could cause electromagnetic forces larger than the weight of an Airbus A380. Furthermore, the thermal loads in such an event could exceed the melting threshold of the most resistant state-of-the-art materials by more than an order of magnitude. To prevent disruptionsor at least mitigate their detrimental effects, empirical models obtained with artificial intelligence methods, of which an overview is given here, are commonly employed to predict their occurrence—and ideally give enough time to introduce counteracting measures.

Published
2022
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34. Ultrafast coherent X-ray diffractive imaging with the FLASH Free-Electron Laser

Author

Chapman, H. N., Bajt, S., Barty, A., Benner, W. H., Bogan, M. J., Boutet, S., Cavalleri, A., Düsterer, S., Frank, M., Hajdu, J., Hau-Riege, S. P., Iwan, B., Marchesini, S., Sokolowski-Tinten, K., Siebert, M. M., Treusch, R., Woods, B. W., Corkum, Paul, editor, Silvestri, Sandro, editor, Nelson, Keith A., editor, Riedle, Eberhard, editor, and Schoenlein, Robert W., editor

Published
2009
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35. Non-Intrusive Velocity Measurements with MTV During DCC Event in the HTTF

Author

Andre, M. A, Bardet, P. M, Cadell, S. R, Woods, B, Burns, R. A, and Danehy, P. M

Subjects
Fluid Mechanics And Thermodynamics
Abstract

Velocity profiles are measured using molecular tagging velocimetry (MTV) in the high temperature test facility (HTTF) at Oregon State University during a depressurized conduction cooldown (DCC) event. The HTTF is a quarter scale electrically heated nuclear reactor simulator designed to replicate various accident scenarios. During a DCC, a double ended guillotine break results in the reactor pressure vessel (RPV) depressurizing into the reactor cavity and ultimately leading to air ingress in the reactor core (lock-exchange and gas diffusion). It is critical to understand the resulting buoyancy-driven flow to characterize the reactor self-cooling capacity through natural circulation. During tests conducted at ambient pressure and temperature, the RPV containing helium is opened (via the hot and cold legs) to a large vessel filled with nitrogen to simulate the atmosphere. The velocity profile on the hot leg pipe centerline is recorded at 10 Hz with MTV based on NO tracers. The precision of the velocimetry was measured to be 0.02 m/s in quiescent flow prior to the tests. A helium flow from the RPV is initially observed in the top quarter of the pipe. During the first 20 seconds of the event, helium flows out of the RPV with a maximum velocity below 2 m/s. The velocity profile transitions from parabolic to linear in character and decays slowly over the rest of the recording; peak velocities of 0.2 m/s are observed after 30 min. A counter-flow of nitrogen is also observed intermittently, which occurs at lower velocities (>0.1 m/s).

Published
2017

36. Development of a Molecular Tagging Velocimetry Technique for Non-Intrusive Velocity Measurements in Low-Speed Gas Flows

Author

Andre, M. A, Bardet, P. M, Cadell, S. R, Woods, B, Burns, R. A, and Danehy, P. M

Subjects
Instrumentation And Photography
Abstract

N2O molecular tagging velocimetry (N2O-MTV) is developed for use in very-high-temperature reactor environments. Tests were carried out to determine the optimum excitation wavelength, tracer concentration, and timing parameters for the laser system. Using NO tracers obtained from photo-dissociation of N2O, velocity profiles are successfully obtained in air, nitrogen, and helium for a large range of parameters: temperature from 295 to 781 K, pressure from 1 to 3 bars, with a velocity precision of 0.01 m/s. Furthermore, by using two read pulses at adjustable time delays, the velocity dynamic range can be increased. An unprecedented dynamic range of 5,000 has been obtained to successfully resolve the flow during a helium blowdown from 1000 m/s down to 0.2 m/s. This technique is also applied to the high-temperature test facility (HTTF) at Oregon State University (OSU) during a depressurized condition cooldown (DCC) event. Details of these measurements are presented in a companion paper. This technique shows a strong potential for fundamental understanding of gas flows in nuclear reactors and to provide benchmark experimental data to validate numerical simulations.

Published
2017

37. Small cell lung cancer recurring in the retina.

Author

Marks, S, Woods, B, Higgins, M, Connell, P, Marks, S, Woods, B, Higgins, M, and Connell, P

Abstract

Intraocular metastases are rare, usually isolating to the uveal tract. Retinal metastases are less common still, presenting a unique diagnostic and therapeutic challenge. This case observes a 66-year-old female ex-smoker presenting with unilateral painful vision loss 2 months from completion of definitive chemoradiotherapy for early-stage small cell lung cancer. A retinal lesion was discovered on examination and initially treated as viral retinitis without improvement. Two vitrectomy procedures were unable to confirm the diagnosis. Eventual retinal biopsy under general anaesthesia confirmed small cell lung cancer oligometastasis (7 months from completion of definitive chemoradiotherapy), without evidence of other sites of disease on imaging. She received local radiation to retina with resolution of eye pain. She eventually developed intrathoracic relapse of disease and was treated with palliative chemotherapy (14 months from completion of definitive chemoradiotherapy).

Published
2022

38. Overview of JET results for optimising ITER operation

Author

Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Ben Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, I, Carvalho, P, Casiraghi, I, Casson, F, Castaldo, C, Catalan, J, Catarino, N, Causa, F, Cavedon, M, Cecconello, M, Challis, C, Chamberlain, B, Chang, C, Chankin, A, Chapman, B, Chernyshova, M, Chiariello, A, Chmielewski, P, Chomiczewska, A, Chone, L, Ciraolo, G, Ciric, D, Clark, M, Clarkson, R, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Coelho, R, Coenen, J, Coffey, I, Colangeli, A, Colas, L, Collins, C, Collins, J, Collins, S, Conka, D, Conroy, S, Conway, B, Conway, N, Coombs, D, Cooper, P, Cooper, S, Corradino, C, Corrigan, G, Coster, D, Cox, P, Craciunescu, T, Cramp, S, Crapper, C, Craven, D, Craven, R, Esposito, M, Croci, G, Croft, D, Croitoru, A, Crombe, K, Cronin, T, Cruz, N, Crystal, C, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarski, T, Dabirikhah, H, Dal Molin, A, Dale, E, Dalgliesh, P, Dalley, S, Dankowski, J, David, P, Davies, A, Davies, S, Davis, G, Dawson, K, Dawson, S, Day, I, De Bock, M, De Temmerman, G, De Tommasi, G, Deakin, K, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Del-Castillo-Negrete, D, Dempsey, A, Dendy, R, Devynck, P, Di Siena, A, Di Troia, C, Dickson, T, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, R, Donne, A, Dorling, S, Dormido-Canto, S, Douai, D, Dowson, S, Doyle, R, Dreval, M, Drewelow, P, Drews, P, Drummond, G, Duckworth, P, Dudding, H, Dumont, R, Dumortier, P, Dunai, D, Dunatov, T, Dunne, M, Durodie, F, Dux, R, Dvornova, A, Eastham, R, Edwards, J, Eich, T, Eichorn, A, Eidietis, N, Eksaeva, A, El Haroun, H, Ellwood, G, Elsmore, C, Embreus, O, Emery, S, Ericsson, G, Eriksson, B, Eriksson, F, Eriksson, J, Eriksson, L, Ertmer, S, Esquembri, S, Esquisabel, A, Estrada, T, Evans, G, Evans, S, Fable, E, Fagan, D, Faitsch, M, Falessi, M, Fanni, A, Farahani, A, Farquhar, I, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, R, Fernandes, A, Fernandes, H, Ferrand, J, Ferreira, D, Ferreira, J, Ferro, G, Fessey, J, Ficker, O, Field, A, Figueiredo, A, Figueiredo, J, Fil, A, Fil, N, Finburg, P, Fiorucci, D, Fischer, U, Fishpool, G, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontana, M, Fontdecaba, J, Forbes, S, Formisano, A, Fornal, T, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Fowler, C, Fransson, E, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fulop, T, Furseman, M, Fusco, V, Futatani, S, Gadariya, D, Gal, K, Galassi, D, Galazka, K, Galeani, S, Gallart, D, Galvao, R, Gao, Y, Garcia, J, Garcia-Munoz, M, Gardener, M, Garzotti, L, Gaspar, J, Gatto, R, Gaudio, P, Gear, D, Gebhart, T, Gee, S, Gelfusa, M, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Gherendi, M, Ghezzi, F, Giacalone, J, Giacomelli, L, Giacometti, G, Gibson, C, Gibson, K, Gil, L, Gillgren, A, Gin, D, Giovannozzi, E, Giroud, C, Glen, R, Gloggler, S, Goff, J, Gohil, P, Goloborodko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gore, S, Gorini, G, Gorler, T, Gotts, N, Goulding, R, Gow, E, Graham, B, Graves, J, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Gromelski, W, Groth, M, Grove, R, Gruca, M, Guard, D, Gupta, N, Gurl, C, Gusarov, A, Hackett, L, Hacquin, S, Hager, R, Hagg, L, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamaguchi, D, Hamed, M, Hamlyn-Harris, C, Hammond, K, Harford, E, Harrison, J, Harting, D, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hayashi, T, Hazael, S, Hazel, S, Heesterman, P, Heidbrink, B, Helou, W, Hemming, O, Henderson, S, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hill, J, Hillesheim, J, Hizanidis, K, Hjalmarsson, A, Ho, A, Hobirk, J, Hoenen, O, Hogben, C, Hollingsworth, A, Hollis, S, Hollmann, E, Holzl, M, Homan, B, Hook, M, Hopley, D, Horsley, D, Horsten, N, Horton, A, Horton, L, Horvath, L, Hotchin, S, Howell, R, Hu, Z, Huber, A, Huber, V, Huddleston, T, Huijsmans, G, Huynh, P, Hynes, A, Iliasova, M, Imrie, D, Imrisek, M, Ingleby, J, Innocente, P, Bjork, K, Isernia, N, Ivanova-Stanik, I, Ivings, E, Jablonski, S, Jachmich, S, Jackson, T, Jacquet, P, Jarleblad, H, Jaulmes, F, Rodriguez, J, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Jones, C, Jones, G, Jones, L, Jones, N, Jones, T, Joyce, A, Juarez, R, Juvonen, M, Kaltiaisenaho, T, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kashchuk, Y, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Kelly, R, Kempenaars, M, Kennedy, C, Kennedy, D, Kent, J, Khan, K, Khilkevich, E, Kiefer, C, Kilpelainen, J, Kim, C, Kim, H, Kim, S, King, D, King, R, Kinna, D, Kiptily, V, Kirjasuo, A, Kirov, K, Kirschner, A, Kiviniemi, T, Kizane, G, Klas, M, Klepper, C, Klix, A, Kneale, G, Knight, M, Knight, P, Knights, R, Knipe, S, Knolker, M, Knott, S, Kocan, M, Kochl, F, Kodeli, I, Kolesnichenko, Y, Kominis, Y, Kong, M, Korovin, V, Kos, B, Kos, D, Koslowski, H, Kotschenreuther, M, Koubiti, M, Koziol, K, Krasilnikov, A, Krasilnikov, V, Kresina, M, Krieger, K, Krishnan, N, Krivska, A, Kruezi, U, Kukushkin, A, Kumpulainen, H, Kurki-Suonio, T, Kurotaki, H, Kwak, S, Kwon, O, Laguardia, L, Lagzdina, E, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, B, Lane, C, Neto, E, Lawson, K, Lazaros, A, Lazzaro, E, Learoyd, G, Lee, C, Lee, S, Leerink, S, Leeson, T, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Gutierrez, E, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lewis, J, Leysen, W, Li, L, Li, Y, Likonen, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Litherland-Smith, E, Liu, F, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lopez, J, Lorenzini, R, Loreti, S, Losada, U, Loschiavo, V, Loughlin, M, Louka, Z, Lovell, J, Lowe, T, Lowry, C, Lubbad, S, Luce, T, Lucock, R, Lukin, A, Luna, C, de la Luna, E, Lungaroni, M, Lungu, C, Lunt, T, Lutsenko, V, Lyons, B, Lyssoivan, A, Machielsen, M, Macusova, E, Maenpaa, R, Maggi, C, Maggiora, R, Magness, M, Mahesan, S, Maier, H, Maingi, R, Malinowski, K, Manas, P, Mantica, P, Mantsinen, M, Manyer, J, Manzanares, A, Maquet, P, Marceca, G, Marcenko, N, Marchetto, C, Marchuk, O, Mariani, A, Mariano, G, Marin, M, Marinelli, M, Markovic, T, Marocco, D, Marot, L, Marsden, S, Marsh, J, Marshall, R, Martellucci, L, Martin, A, Martone, R, Maruyama, S, Maslov, M, Masuzaki, S, Matejcik, S, Mattei, M, Matthews, G, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, Mayer, M, Mayoral, M, Mazzi, S, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mcclenaghan, J, Mccullen, P, Mcdonald, D, Mcguckin, D, Mchugh, D, Mcintyre, G, Mckean, R, Mckehon, J, Mcmillan, B, Mcnamee, L, Mcshee, A, Meakins, A, Medley, S, Meekes, C, Meghani, K, Meigs, A, Meisl, G, Meitner, S, Menmuir, S, Mergia, K, Merriman, S, Mertens, P, Meshchaninov, S, Messiaen, A, Michling, R, Middleton, P, Middleton-Gear, D, Mietelski, J, Milanesio, D, Milani, E, Militello, F, Asp, A, Milnes, J, Milocco, A, Miloshevsky, G, Minghao, C, Minucci, S, Miron, I, Miyamoto, M, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moody, T, Moon, S, Mooney, R, Moradi, S, Morales, J, Morales, R, Mordijck, S, Moreira, L, Morgan, L, Moro, F, Morris, J, Morrison, K, Msero, L, Moulton, D, Mrowetz, T, Mundy, T, Muraglia, M, Murari, A, Muraro, A, Muthusonai, N, Na, Y, Nabais, F, Naden, M, Naish, J, Naish, R, Napoli, F, Nardon, E, Naulin, V, Nave, M, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nestoras, I, Neu, R, Neverov, V, Ng, S, Nicassio, M, Nielsen, A, Nina, D, Nishijima, D, Noble, C, Nobs, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, J, Nowak, S, Nunn, E, Nystrom, H, Oberparleiter, M, Obryk, B, O'Callaghan, J, Odupitan, T, Oliver, H, Olney, R, O'Mullane, M, Ongena, J, Organ, E, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Otsuka, T, Owen, A, Oya, Y, Oyaizu, M, Paccagnella, R, Pace, N, Packer, L, Paige, S, Pajuste, E, Palade, D, Pamela, S, Panadero, N, Panontin, E, Papadopoulos, A, Papp, G, Papp, P, Parail, V, Pardanaud, C, Parisi, J, Diaz, F, Parsloe, A, Parsons, M, Parsons, N, Passeri, M, Patel, A, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, C, Peacock, A, Pearce, M, Peluso, E, Penot, C, Pepperell, K, Pereira, R, Pereira, T, Cippo, E, Pereslavtsev, P, von Thun, C, Pericoli, V, Perry, D, Peterka, M, Petersson, P, Petravich, G, Petrella, N, Peyman, M, Pillon, M, Pinches, S, Pintsuk, G, de Sa, W, dos Reis, A, Piron, C, Pionr, L, Pironti, A, Pitts, R, van de Plassche, K, Platt, N, Plyusnin, V, Podesta, M, Pokol, G, Poli, F, Pompilian, O, Popovichev, S, Poradzinski, M, Porfiri, M, Porkolab, M, Porosnicu, C, Porton, M, Poulipoulis, G, Predebon, I, Prestopino, G, Price, C, Price, D, Price, M, Primetzhofer, D, Prior, P, Provatas, G, Pucella, G, Puglia, P, Purahoo, K, Pusztai, I, Putignano, O, Putterich, T, Quercia, A, Rachlew, E, Radulescu, G, Radulovic, V, Rainford, M, Raj, P, Ralph, G, Ramogida, G, Rasmussen, D, Rasmussen, J, Ratta, G, Ratynskaia, S, Rebai, M, Refy, D, Reichle, R, Reinke, M, Reiser, D, Reux, C, Reynolds, S, Richiusa, M, Richyal, S, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Ramos, M, Rodriguez-Fernandez, P, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rossi, R, Rowe, S, Rowlands, D, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruiz, J, Ruset, C, Rzadkiewicz, J, Saarelma, S, Safi, E, Sahlberg, A, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Sanders, I, Sandiford, D, Santos, B, Santucci, A, Sarkimaki, K, Sarwar, R, Sarychev, I, Sauter, O, Sauwan, P, Scapin, N, Schluck, F, Schmid, K, Schmuck, S, Schneider, M, Schneider, P, Schworer, D, Scott, G, Scott, M, Scraggs, D, Scully, S, Segato, M, Seo, J, Sergienko, G, Sertoli, M, Sharapov, S, Shaw, A, Sheikh, H, Sheikh, U, Shepherd, A, Shevelev, A, Shigin, P, Shinohara, K, Shiraiwa, S, Shiraki, D, Short, M, Sias, G, Silburn, S, Silva, A, Silva, C, Silva, J, Silvagni, D, Simfukwe, D, Simpson, J, Sinclair, D, Sipila, S, Sips, A, Siren, P, Sirinelli, A, Sjostrand, H, Skinner, N, Slater, J, Smith, N, Smith, P, Snell, J, Snoep, G, Snoj, L, Snyder, P, Soare, S, Solano, E, Solokha, V, Somers, A, Sommariva, C, Soni, K, Sorokovoy, E, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Spelzini, T, Spineanu, F, Spong, D, Sprada, D, Sridhar, S, Srinivasan, C, Stables, G, Staebler, G, Stamatelatos, I, Stancar, Z, Staniec, P, Stankunas, G, Stead, M, Stefanikova, E, Stephen, A, Stephens, J, Stevenson, P, Stojanov, M, Strand, P, Strauss, H, Strikwerda, S, Strom, P, Stuart, C, Studholme, W, Subramani, M, Suchkov, E, Sumida, S, Sun, H, Susts, T, Svensson, J, Svoboda, J, Sweeney, R, Sytnykov, D, Szabolics, T, Szepesi, G, Tabia, B, Tadic, T, Tal, B, Tala, T, Tallargio, A, Tamain, P, Tan, H, Tanaka, K, Tang, W, Tardocchi, M, Taylor, D, Teimane, A, Telesca, G, Teplova, N, Teplukhina, A, Terentyev, D, Terra, A, Terranova, D, Terranova, N, Testa, D, Tholerus, E, Thomas, J, Thoren, E, Thorman, A, Tierens, W, Tinguely, R, Tipton, A, Todd, H, Tokitani, M, Tolias, P, Tomes, M, Tookey, A, 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M, Welch, P, Wendler, N, West, A, Wheatley, M, Wheeler, S, Whitehead, A, Whittaker, D, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Willoughby, D, Wilson, I, Wilson, J, Wilson, T, Wischmeier, M, Wise, P, Withenshaw, G, Withycombe, A, Witts, D, Wojcik-Gargula, A, Wolfrum, E, Wood, R, Woodley, C, Woodley, R, Woods, B, Wright, J, Xu, T, Yadikin, D, Yajima, M, Yakovenko, Y, Yang, Y, Yanling, W, Yanovskiy, V, Young, I, Young, R, Zabolockis, R, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zarins, A, Fernandez, D, Zastrow, K, Zayachuk, Y, Zerbini, M, Zhang, W, Zhou, Y, Zlobinski, M, Zocco, A, Zohar, A, Zoita, V, Zoletnik, S, Zotta, V, Zoulias, I, Zwingmann, W, Zychor, I, Alekseev, AG, Sunden, EA, Angelini, BM, Appel, LC, Bandaru, VK, Baranov, YF, Beaumont, PS, Bizarro, JPS, Mihalic, IB, Bradnam, SC, Carvalho, IS, Casson, FJ, Catalan, JP, Challis, CD, Chang, CS, Coad, JP, Coenen, JW, Coffey, IH, Conway, NJ, Esposito, MC, Day, IE, Dendy, RO, Doerner, RP, Donne, AJH, Eriksson, LG, 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Abstract

The JET 2019-2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major neutral beam injection upgrade providing record power in 2019-2020, and tested the technical and procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle (alpha) physics in the coming D-T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed shattered pellet injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design and operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D-T benefited from the highest D-D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER.

Published
2022

39. Trajectories of relationship quality in dementia: a longitudinal study in eight European countries

Author

Marques, M.J., Tan, E.Y.L., Woods, B., Jelley, H., Kerpershoek, L., Hopper, L., Irving, K., Bieber, A., Stephan, A., Skoldunger, A., Sjolund, B.M., Selbaek, G., Rosvik, J., Zanetti, O., Portolani, D.M., Maroco, J., de Vugt, M., Verhey, F., Goncalves-Pereira, M., ActifCare Consortium, Marques, M.J., Tan, E.Y.L., Woods, B., Jelley, H., Kerpershoek, L., Hopper, L., Irving, K., Bieber, A., Stephan, A., Skoldunger, A., Sjolund, B.M., Selbaek, G., Rosvik, J., Zanetti, O., Portolani, D.M., Maroco, J., de Vugt, M., Verhey, F., Goncalves-Pereira, M., and ActifCare Consortium

Abstract

Objectives Relationship quality (RQ) between a person with dementia and a family carer may influence their health and quality of life. However, evidence regarding its course and influencing factors is limited. We aimed to explore RQ trajectories in dementia, and identify predictors of change. Methods We analysed longitudinal data from a cohort of 350 community-dwelling people with dementia and their informal carers, participating in the Actifcare study in eight European countries. The Positive Affect Index, rated separately by both people with dementia and their carers, assessed RQ. Other measures included the Neuropsychiatric Inventory Questionnaire (regarding persons with dementia), and the Relative Stress Scale, Sense of Coherence Scale and Lubben Social Network Scale (for carers). Trajectories and influencing factors were explored applying a latent growth model (LGM). Results RQ in the group of carers declined over 1 year, but RQ scores for the persons with dementia did not change. Higher stress in carers negatively influenced their baseline RQ ratings. Carer sense of coherence and being a spouse were associated with more positive baseline RQ carer assessments. Higher levels of neuropsychiatric symptoms were linked to decline in carers' RQ, whereas social support was associated with more positive RQ trajectories. Conclusion This study provides a valuable insight into the course of RQ. LGM proved useful to explore the factors that influence RQ trajectories and variability within- and between-persons. Our findings emphasise the importance of carer-perceived social support and sense of coherence, and of reducing neuropsychiatric symptoms, in maintaining a good RQ.

Published
2022

40. Overview of JET results for optimising ITER operation

Author

Mailloux, J., primary, Abid, N., additional, Abraham, K., additional, Abreu, P., additional, Adabonyan, O., additional, Adrich, P., additional, Afanasev, V., additional, Afzal, M., additional, Ahlgren, T., additional, Aho-Mantila, L., additional, Aiba, N., additional, Airila, M., additional, Akhtar, M., additional, Albanese, R., additional, Alderson-Martin, M., additional, Alegre, D., additional, Aleiferis, S., additional, Aleksa, A., additional, Alekseev, A.G., additional, Alessi, E., additional, Aleynikov, P., additional, Algualcil, J., additional, Ali, M., additional, Allinson, M., additional, Alper, B., additional, Alves, E., additional, Ambrosino, G., additional, Ambrosino, R., additional, Amosov, V., additional, Sundén, E.Andersson, additional, Andrew, P., additional, Angelini, B.M., additional, Angioni, C., additional, Antoniou, I., additional, Appel, L.C., additional, Appelbee, C., additional, Aria, S., additional, Ariola, M., additional, Artaserse, G., additional, Arter, W., additional, Artigues, V., additional, Asakura, N., additional, Ash, A., additional, Ashikawa, N., additional, Aslanyan, V., additional, Astrain, M., additional, Asztalos, O., additional, Auld, D., additional, Auriemma, F., additional, Austin, Y., additional, Avotina, L., additional, Aymerich, E., additional, Baciero, A., additional, Bairaktaris, F., additional, Balbin, J., additional, Balbinot, L., additional, Balboa, I., additional, Balden, M., additional, Balshaw, C., additional, Balshaw, N., additional, Bandaru, V.K., additional, Banks, J., additional, Baranov, Yu.F., additional, Barcellona, C., additional, Barnard, A., additional, Barnard, M., additional, Barnsley, R., additional, Barth, A., additional, Baruzzo, M., additional, Barwell, S., additional, Bassan, M., additional, Batista, A., additional, Batistoni, P., additional, Baumane, L., additional, Bauvir, B., additional, Baylor, L., additional, Beaumont, P.S., additional, Beckett, D., additional, Begolli, A., additional, Beidler, M., additional, Bekris, N., additional, Beldishevski, M., additional, Belli, E., additional, Belli, F., additional, Belonohy, É., additional, Ben Yaala, M., additional, Benayas, J., additional, Bentley, J., additional, Bergsåker, H., additional, Bernardo, J., additional, Bernert, M., additional, Berry, M., additional, Bertalot, L., additional, Betar, H., additional, Beurskens, M., additional, Bickerton, S., additional, Bieg, B., additional, Bielecki, J., additional, Bierwage, A., additional, Biewer, T., additional, Bilato, R., additional, Bílková, P., additional, Birkenmeier, G., additional, Bishop, H., additional, Bizarro, J.P.S., additional, Blackburn, J., additional, Blanchard, P., additional, Blatchford, P., additional, Bobkov, V., additional, Boboc, A., additional, Bohm, P., additional, Bohm, T., additional, Bolshakova, I., additional, Bolzonella, T., additional, Bonanomi, N., additional, Bonfiglio, D., additional, Bonnin, X., additional, Bonofiglo, P., additional, Boocock, S., additional, Booth, A., additional, Booth, J., additional, Borba, D., additional, Borodin, D., additional, Borodkina, I., additional, Boulbe, C., additional, Bourdelle, C., additional, Bowden, M., additional, Boyd, K., additional, Mihalić, I.Božičević, additional, Bradnam, S.C., additional, Braic, V., additional, Brandt, L., additional, Bravanec, R., additional, Breizman, B., additional, Brett, A., additional, Brezinsek, S., additional, Brix, M., additional, Bromley, K., additional, Brown, B., additional, Brunetti, D., additional, Buckingham, R., additional, Buckley, M., additional, Budny, R., additional, Buermans, J., additional, Bufferand, H., additional, Buratti, P., additional, Burgess, A., additional, Buscarino, A., additional, Busse, A., additional, Butcher, D., additional, Cal, E.de la, additional, Calabrò, G., additional, Calacci, L., additional, Calado, R., additional, Camenen, Y., additional, Canal, G., additional, Cannas, B., additional, Cappelli, M., additional, Carcangiu, S., additional, Card, P., additional, Cardinali, A., additional, Carman, P., additional, Carnevale, D., additional, Carr, M., additional, Carralero, D., additional, Carraro, L., additional, Carvalho, I.S., additional, Carvalho, P., additional, Casiraghi, I., additional, Casson, F.J., additional, Castaldo, C., additional, Catalan, J.P., additional, Catarino, N., additional, Causa, F., additional, Cavedon, M., additional, Cecconello, M., additional, Challis, C.D., additional, Chamberlain, B., additional, Chang, C.S., additional, Chankin, A., additional, Chapman, B., additional, Chernyshova, M., additional, Chiariello, A., additional, Chmielewski, P., additional, Chomiczewska, A., additional, Chone, L., additional, Ciraolo, G., additional, Ciric, D., additional, Citrin, J., additional, Ciupinski, Ł., additional, Clark, M., additional, Clarkson, R., additional, Clements, C., additional, Cleverly, M., additional, Coad, J.P., additional, Coates, P., additional, Cobalt, A., additional, Coccorese, V., additional, Coelho, R., additional, Coenen, J.W., additional, Coffey, I.H., additional, Colangeli, A., additional, Colas, L., additional, Collins, C., additional, Collins, J., additional, Collins, S., additional, Conka, D., additional, Conroy, S., additional, Conway, B., additional, Conway, N.J., additional, Coombs, D., additional, Cooper, P., additional, Cooper, S., additional, Corradino, C., additional, Corrigan, G., additional, Coster, D., additional, Cox, P., additional, Craciunescu, T., additional, Cramp, S., additional, Crapper, C., additional, Craven, D., additional, Craven, R., additional, Esposito, M.Crialesi, additional, Croci, G., additional, Croft, D., additional, Croitoru, A., additional, Crombé, K., additional, Cronin, T., additional, Cruz, N., additional, Crystal, C., additional, Cseh, G., additional, Cufar, A., additional, Cullen, A., additional, Curuia, M., additional, Czarski, T., additional, Dabirikhah, H., additional, Molin, A.Dal, additional, Dale, E., additional, Dalgliesh, P., additional, Dalley, S., additional, Dankowski, J., additional, David, P., additional, Davies, A., additional, Davies, S., additional, Davis, G., additional, Dawson, K., additional, Dawson, S., additional, Day, I.E., additional, De Bock, M., additional, De Temmerman, G., additional, De Tommasi, G., additional, Deakin, K., additional, Deane, J., additional, Dejarnac, R., additional, Del Sarto, D., additional, Delabie, E., additional, Del-Castillo-Negrete, D., additional, Dempsey, A., additional, Dendy, R.O., additional, Devynck, P., additional, Di Siena, A., additional, Di Troia, C., additional, Dickson, T., additional, Dinca, P., additional, Dittmar, T., additional, Dobrashian, J., additional, Doerner, R.P., additional, Donné, A.J.H., additional, Dorling, S., additional, Dormido-Canto, S., additional, Douai, D., additional, Dowson, S., additional, Doyle, R., additional, Dreval, M., additional, Drewelow, P., additional, Drews, P., additional, Drummond, G., additional, Duckworth, Ph., additional, Dudding, H., additional, Dumont, R., additional, Dumortier, P., additional, Dunai, D., additional, Dunatov, T., additional, Dunne, M., additional, Ďuran, I., additional, Durodié, F., additional, Dux, R., additional, Dvornova, A., additional, Eastham, R., additional, Edwards, J., additional, Eich, Th., additional, Eichorn, A., additional, Eidietis, N., additional, Eksaeva, A., additional, El Haroun, H., additional, Ellwood, G., additional, Elsmore, C., additional, Embreus, O., additional, Emery, S., additional, Ericsson, G., additional, Eriksson, B., additional, Eriksson, F., additional, Eriksson, J., additional, Eriksson, L.G., additional, Ertmer, S., additional, Esquembri, S., additional, Esquisabel, A.L., additional, Estrada, T., additional, Evans, G., additional, Evans, S., additional, Fable, E., additional, Fagan, D., additional, Faitsch, M., additional, Falessi, M., additional, Fanni, A., additional, Farahani, A., additional, Farquhar, I., additional, Fasoli, A., additional, Faugeras, B., additional, Fazinić, S., additional, Felici, F., additional, Felton, R., additional, Fernandes, A., additional, Fernandes, H., additional, Ferrand, J., additional, Ferreira, D.R., additional, Ferreira, J., additional, Ferrò, G., additional, Fessey, J., additional, Ficker, O., additional, Field, A.R., additional, Figueiredo, A., additional, Figueiredo, J., additional, Fil, A., additional, Fil, N., additional, Finburg, P., additional, Fiorucci, D., additional, Fischer, U., additional, Fishpool, G., additional, Fittill, L., additional, Fitzgerald, M., additional, Flammini, D., additional, Flanagan, J., additional, Flinders, K., additional, Foley, S., additional, Fonnesu, N., additional, Fontana, M., additional, Fontdecaba, J.M., additional, Forbes, S., additional, Formisano, A., additional, Fornal, T., additional, Fortuna, L., additional, Fortuna-Zalesna, E., additional, Fortune, M., additional, Fowler, C., additional, Fransson, E., additional, Frassinetti, L., additional, Freisinger, M., additional, Fresa, R., additional, Fridström, R., additional, Frigione, D., additional, Fülöp, T., additional, Furseman, M., additional, Fusco, V., additional, Futatani, S., additional, Gadariya, D., additional, Gál, K., additional, Galassi, D., additional, Gałązka, K., additional, Galeani, S., additional, Gallart, D., additional, Galvão, R., additional, Gao, Y., additional, Garcia, J., additional, García-Muñoz, M., additional, Gardener, M., additional, Garzotti, L., additional, Gaspar, J., additional, Gatto, R., additional, Gaudio, P., additional, Gear, D., additional, Gebhart, T., additional, Gee, S., additional, Gelfusa, M., additional, George, R., additional, Gerasimov, S.N., additional, Gervasini, G., additional, Gethins, M., additional, Ghani, Z., additional, Gherendi, M., additional, Ghezzi, F., additional, Giacalone, J.C., additional, Giacomelli, L., additional, Giacometti, G., additional, Gibson, C., additional, Gibson, K.J., additional, Gil, L., additional, Gillgren, A., additional, Gin, D., additional, Giovannozzi, E., additional, Giroud, C., additional, Glen, R., additional, Glöggler, S., additional, Goff, J., additional, Gohil, P., additional, Goloborodko, V., additional, Gomes, R., additional, Gonçalves, B., additional, Goniche, M., additional, Goodyear, A., additional, Gore, S., additional, Gorini, G., additional, Görler, T., additional, Gotts, N., additional, Goulding, R., additional, Gow, E., additional, Graham, B., additional, Graves, J.P., additional, Greuner, H., additional, Grierson, B., additional, Griffiths, J., additional, Griph, S., additional, Grist, D., additional, Gromelski, W., additional, Groth, M., additional, Grove, R., additional, Gruca, M., additional, Guard, D., additional, Gupta, N., additional, Gurl, C., additional, Gusarov, A., additional, Hackett, L., additional, Hacquin, S., additional, Hager, R., additional, Hägg, L., additional, Hakola, A., additional, Halitovs, M., additional, Hall, S., additional, Hall, S.A., additional, Hallworth-Cook, S., additional, Ham, C.J., additional, Hamaguchi, D., additional, Hamed, M., additional, Hamlyn-Harris, C., additional, Hammond, K., additional, Harford, E., additional, Harrison, J.R., additional, Harting, D., additional, Hatano, Y., additional, Hatch, D.R., additional, Haupt, T., additional, Hawes, J., additional, Hawkes, N.C., additional, Hawkins, J., additional, Hayashi, T., additional, Hazael, S., additional, Hazel, S., additional, Heesterman, P., additional, Heidbrink, B., additional, Helou, W., additional, Hemming, O., additional, Henderson, S.S., additional, Henriques, R.B., additional, Hepple, D., additional, Herfindal, J., additional, Hermon, G., additional, Hill, J., additional, Hillesheim, J.C., additional, Hizanidis, K., additional, Hjalmarsson, A., additional, Ho, A., additional, Hobirk, J., additional, Hoenen, O., additional, Hogben, C., additional, Hollingsworth, A., additional, Hollis, S., additional, Hollmann, E., additional, Hölzl, M., additional, Homan, B., additional, Hook, M., additional, Hopley, D., additional, Horáček, J., additional, Horsley, D., additional, Horsten, N., additional, Horton, A., additional, Horton, L.D., additional, Horvath, L., additional, Hotchin, S., additional, Howell, R., additional, Hu, Z., additional, Huber, A., additional, Huber, V., additional, Huddleston, T., additional, Huijsmans, G.T.A., additional, Huynh, P., additional, Hynes, A., additional, Iliasova, M., additional, Imrie, D., additional, Imríšek, M., additional, Ingleby, J., additional, Innocente, P., additional, Insulander Björk, K., additional, Isernia, N., additional, Ivanova-Stanik, I., additional, Ivings, E., additional, Jablonski, S., additional, Jachmich, S., additional, Jackson, T., additional, Jacquet, P., additional, Järleblad, H., additional, Jaulmes, F., additional, Rodriguez, J.Jenaro, additional, Jepu, I., additional, Joffrin, E., additional, Johnson, R., additional, Johnson, T., additional, Johnston, J., additional, Jones, C., additional, Jones, G., additional, Jones, L., additional, Jones, N., additional, Jones, T., additional, Joyce, A., additional, Juarez, R., additional, Juvonen, M., additional, Kalniņa, P., additional, Kaltiaisenaho, T., additional, Kaniewski, J., additional, Kantor, A., additional, Kappatou, A., additional, Karhunen, J., additional, Karkinsky, D., additional, Kashchuk, Yu, additional, Kaufman, M., additional, Kaveney, G., additional, Kazakov, Ye.O., additional, Kazantzidis, V., additional, Keeling, D.L., additional, Kelly, R., additional, Kempenaars, M., additional, Kennedy, C., additional, Kennedy, D., additional, Kent, J., additional, Khan, K., additional, Khilkevich, E., additional, Kiefer, C., additional, Kilpeläinen, J., additional, Kim, C., additional, Kim, Hyun-Tae, additional, Kim, S.H., additional, King, D.B., additional, King, R., additional, Kinna, D., additional, Kiptily, V.G., additional, Kirjasuo, A., additional, Kirov, K.K., additional, Kirschner, A., additional, kiviniemi, T., additional, Kizane, G., additional, Klas, M., additional, Klepper, C., additional, Klix, A., additional, Kneale, G., additional, Knight, M., additional, Knight, P., additional, Knights, R., additional, Knipe, S., additional, Knolker, M., additional, Knott, S., additional, Kocan, M., additional, Köchl, F., additional, Kodeli, I., additional, Kolesnichenko, Y., additional, Kominis, Y., additional, Kong, M., additional, Korovin, V., additional, Kos, B., additional, Kos, D., additional, Koslowski, H.R., additional, Kotschenreuther, M., additional, Koubiti, M., additional, Kowalska-Strzęciwilk, E., additional, Koziol, K., additional, Krasilnikov, A., additional, Krasilnikov, V., additional, Kresina, M., additional, Krieger, K., additional, Krishnan, N., additional, Krivska, A., additional, Kruezi, U., additional, Książek, I., additional, Kukushkin, A.B., additional, Kumpulainen, H., additional, Kurki-Suonio, T., additional, Kurotaki, H., additional, Kwak, S., additional, Kwon, O.J., additional, Laguardia, L., additional, Lagzdina, E., additional, Lahtinen, A., additional, Laing, A., additional, Lam, N., additional, Lambertz, H.T., additional, Lane, B., additional, Lane, C., additional, Neto, E.Lascas, additional, Łaszyńska, E., additional, Lawson, K.D., additional, Lazaros, A., additional, Lazzaro, E., additional, Learoyd, G., additional, Lee, Chanyoung, additional, Lee, S.E., additional, Leerink, S., additional, Leeson, T., additional, Lefebvre, X., additional, Leggate, H.J., additional, Lehmann, J., additional, Lehnen, M., additional, Leichtle, D., additional, Leipold, F., additional, Lengar, I., additional, Lennholm, M., additional, Gutierrez, E. Leon, additional, Lepiavko, B., additional, Leppänen, J., additional, Lerche, E., additional, Lescinskis, A., additional, Lewis, J., additional, Leysen, W., additional, Li, L., additional, Li, Y., additional, Likonen, J., additional, Linsmeier, Ch., additional, Lipschultz, B., additional, Litaudon, X., additional, Litherland-Smith, E., additional, Liu, F., additional, Loarer, T., additional, Loarte, A., additional, Lobel, R., additional, Lomanowski, B., additional, Lomas, P.J., additional, López, J.M., additional, Lorenzini, R., additional, Loreti, S., additional, Losada, U., additional, Loschiavo, V.P., additional, Loughlin, M., additional, Louka, Z., additional, Lovell, J., additional, Lowe, T., additional, Lowry, C., additional, Lubbad, S., additional, Luce, T., additional, Lucock, R., additional, Lukin, A., additional, Luna, C., additional, Luna, E.de la, additional, Lungaroni, M., additional, Lungu, C.P., additional, Lunt, T., additional, Lutsenko, V., additional, Lyons, B., 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Published
2022
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41. New insights into the genetic etiology of Alzheimer's disease and related dementias

Author

Bellenguez, C. Küçükali, F. Jansen, I.E. Kleineidam, L. Moreno-Grau, S. Amin, N. Naj, A.C. Campos-Martin, R. Grenier-Boley, B. Andrade, V. Holmans, P.A. Boland, A. Damotte, V. van der Lee, S.J. Costa, M.R. Kuulasmaa, T. Yang, Q. de Rojas, I. Bis, J.C. Yaqub, A. Prokic, I. Chapuis, J. Ahmad, S. Giedraitis, V. Aarsland, D. Garcia-Gonzalez, P. Abdelnour, C. Alarcón-Martín, E. Alcolea, D. Alegret, M. Alvarez, I. Álvarez, V. Armstrong, N.J. Tsolaki, A. Antúnez, C. Appollonio, I. Arcaro, M. Archetti, S. Pastor, A.A. Arosio, B. Athanasiu, L. Bailly, H. Banaj, N. Baquero, M. Barral, S. Beiser, A. Pastor, A.B. Below, J.E. Benchek, P. Benussi, L. Berr, C. Besse, C. Bessi, V. Binetti, G. Bizarro, A. Blesa, R. Boada, M. Boerwinkle, E. Borroni, B. Boschi, S. Bossù, P. Bråthen, G. Bressler, J. Bresner, C. Brodaty, H. Brookes, K.J. Brusco, L.I. Buiza-Rueda, D. Bûrger, K. Burholt, V. Bush, W.S. Calero, M. Cantwell, L.B. Chene, G. Chung, J. Cuccaro, M.L. Carracedo, Á. Cecchetti, R. Cervera-Carles, L. Charbonnier, C. Chen, H.-H. Chillotti, C. Ciccone, S. Claassen, J.A.H.R. Clark, C. Conti, E. Corma-Gómez, A. Costantini, E. Custodero, C. Daian, D. Dalmasso, M.C. Daniele, A. Dardiotis, E. Dartigues, J.-F. de Deyn, P.P. de Paiva Lopes, K. de Witte, L.D. Debette, S. Deckert, J. Del Ser, T. Denning, N. DeStefano, A. Dichgans, M. Diehl-Schmid, J. Diez-Fairen, M. Rossi, P.D. Djurovic, S. Duron, E. Düzel, E. Dufouil, C. Eiriksdottir, G. Engelborghs, S. Escott-Price, V. Espinosa, A. Ewers, M. Faber, K.M. Fabrizio, T. Nielsen, S.F. Fardo, D.W. Farotti, L. Fenoglio, C. Fernández-Fuertes, M. Ferrari, R. Ferreira, C.B. Ferri, E. Fin, B. Fischer, P. Fladby, T. Fließbach, K. Fongang, B. Fornage, M. Fortea, J. Foroud, T.M. Fostinelli, S. Fox, N.C. Franco-Macías, E. Bullido, M.J. Frank-García, A. Froelich, L. Fulton-Howard, B. Galimberti, D. García-Alberca, J.M. García-González, P. Garcia-Madrona, S. Garcia-Ribas, G. Ghidoni, R. Giegling, I. Giorgio, G. Goate, A.M. Goldhardt, O. Gomez-Fonseca, D. González-Pérez, A. Graff, C. Grande, G. Green, E. Grimmer, T. Grünblatt, E. Grunin, M. Gudnason, V. Guetta-Baranes, T. Haapasalo, A. Hadjigeorgiou, G. Haines, J.L. Hamilton-Nelson, K.L. Hampel, H. Hanon, O. Hardy, J. Hartmann, A.M. Hausner, L. Harwood, J. Heilmann-Heimbach, S. Helisalmi, S. Heneka, M.T. Hernández, I. Herrmann, M.J. Hoffmann, P. Holmes, C. Holstege, H. Vilas, R.H. Hulsman, M. Humphrey, J. Biessels, G.J. Jian, X. Johansson, C. Jun, G.R. Kastumata, Y. Kauwe, J. Kehoe, P.G. Kilander, L. Ståhlbom, A.K. Kivipelto, M. Koivisto, A. Kornhuber, J. Kosmidis, M.H. Kukull, W.A. Kuksa, P.P. Kunkle, B.W. Kuzma, A.B. Lage, C. Laukka, E.J. Launer, L. Lauria, A. Lee, C.-Y. Lehtisalo, J. Lerch, O. Lleó, A. Longstreth, W., Jr Lopez, O. de Munain, A.L. Love, S. Löwemark, M. Luckcuck, L. Lunetta, K.L. Ma, Y. Macías, J. MacLeod, C.A. Maier, W. Mangialasche, F. Spallazzi, M. Marquié, M. Marshall, R. Martin, E.R. Montes, A.M. Rodríguez, C.M. Masullo, C. Mayeux, R. Mead, S. Mecocci, P. Medina, M. Meggy, A. Mehrabian, S. Mendoza, S. Menéndez-González, M. Mir, P. Moebus, S. Mol, M. Molina-Porcel, L. Montrreal, L. Morelli, L. Moreno, F. Morgan, K. Mosley, T. Nöthen, M.M. Muchnik, C. Mukherjee, S. Nacmias, B. Ngandu, T. Nicolas, G. Nordestgaard, B.G. Olaso, R. Orellana, A. Orsini, M. Ortega, G. Padovani, A. Paolo, C. Papenberg, G. Parnetti, L. Pasquier, F. Pastor, P. Peloso, G. Pérez-Cordón, A. Pérez-Tur, J. Pericard, P. Peters, O. Pijnenburg, Y.A.L. Pineda, J.A. Piñol-Ripoll, G. Pisanu, C. Polak, T. Popp, J. Posthuma, D. Priller, J. Puerta, R. Quenez, O. Quintela, I. Thomassen, J.Q. Rábano, A. Rainero, I. Rajabli, F. Ramakers, I. Real, L.M. Reinders, M.J.T. Reitz, C. Reyes-Dumeyer, D. Ridge, P. Riedel-Heller, S. Riederer, P. Roberto, N. Rodriguez-Rodriguez, E. Rongve, A. Allende, I.R. Rosende-Roca, M. Royo, J.L. Rubino, E. Rujescu, D. Sáez, M.E. Sakka, P. Saltvedt, I. Sanabria, Á. Sánchez-Arjona, M.B. Sanchez-Garcia, F. Juan, P.S. Sánchez-Valle, R. Sando, S.B. Sarnowski, C. Satizabal, C.L. Scamosci, M. Scarmeas, N. Scarpini, E. Scheltens, P. Scherbaum, N. Scherer, M. Schmid, M. Schneider, A. Schott, J.M. Selbæk, G. Seripa, D. Serrano, M. Sha, J. Shadrin, A.A. Skrobot, O. Slifer, S. Snijders, G.J.L. Soininen, H. Solfrizzi, V. Solomon, A. Song, Y. Sorbi, S. Sotolongo-Grau, O. Spalletta, G. Spottke, A. Squassina, A. Stordal, E. Tartan, J.P. Tárraga, L. Tesí, N. Thalamuthu, A. Thomas, T. Tosto, G. Traykov, L. Tremolizzo, L. Tybjærg-Hansen, A. Uitterlinden, A. Ullgren, A. Ulstein, I. Valero, S. Valladares, O. Broeckhoven, C.V. Vance, J. Vardarajan, B.N. van der Lugt, A. Dongen, J.V. van Rooij, J. van Swieten, J. Vandenberghe, R. Verhey, F. Vidal, J.-S. Vogelgsang, J. Vyhnalek, M. Wagner, M. Wallon, D. Wang, L.-S. Wang, R. Weinhold, L. Wiltfang, J. Windle, G. Woods, B. Yannakoulia, M. Zare, H. Zhao, Y. Zhang, X. Zhu, C. Zulaica, M. Farrer, L.A. Psaty, B.M. Ghanbari, M. Raj, T. Sachdev, P. Mather, K. Jessen, F. Ikram, M.A. de Mendonça, A. Hort, J. Tsolaki, M. Pericak-Vance, M.A. Amouyel, P. Williams, J. Frikke-Schmidt, R. Clarimon, J. Deleuze, J.-F. Rossi, G. Seshadri, S. Andreassen, O.A. Ingelsson, M. Hiltunen, M. Sleegers, K. Schellenberg, G.D. van Duijn, C.M. Sims, R. van der Flier, W.M. Ruiz, A. Ramirez, A. Lambert, J.-C. EADB GR@ACE DEGESCO EADI GERAD Demgene FinnGen ADGC CHARGE

Abstract

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022. The Author(s).

Published
2022

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