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6. Arrhythmia recurrence is more common in females undergoing multiple catheter ablation procedures for persistent atrial fibrillation: Time to close the gender gap

Author

Sugumar, Hariharan, Nanayakkara, Shane, Chieng, David, Wong, Geoffrey R., Parameswaran, Ramanathan, Anderson, Robert D., Al-Kaisey, Ahmed, Nalliah, Chrishan J., Azzopardi, Sonia, Prabhu, Sandeep, Voskoboinik, Aleksandr, Lee, Geoffrey, McLellan, Alex J., Ling, Liang-Han, Morton, Joseph B., Kalman, Jonathan M., and Kistler, Peter M.

Published
2020
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11. Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress

Author

Al-Kaisey, Ahmed M., primary, Parameswaran, Ramanathan, additional, Bryant, Christina, additional, Anderson, Robert D., additional, Hawson, Joshua, additional, Chieng, David, additional, Segan, Louise, additional, Voskoboinik, Aleksandr, additional, Sugumar, Hariharan, additional, Wong, Geoffrey R., additional, Finch, Sue, additional, Joseph, Stephen A., additional, McLellan, Alex, additional, Ling, Liang-Han, additional, Morton, Joseph, additional, Sparks, Paul, additional, Sanders, Prashanthan, additional, Lee, Geoffrey, additional, Kistler, Peter M., additional, and Kalman, Jonathan M., additional

Published
2023
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13. AB-452663-1 THE IMPACT OF LOW POSTERIOR LEFT ATRIAL WALL VOLTAGE ON THE OUTCOMES OF CATHETER ABLATION FOR PERSISTENT ATRIAL FIBRILLATION: A CAPLA RANDOMIZED CLINICAL TRIAL SUBSTUDY

Author

Chieng, David, primary, Sugumar, Hariharan, additional, Hunt, Andrew, additional, Ling, Liang-Han, additional, Segan, Louise, additional, Al-Kaisey, Ahmed, additional, Hawson, Joshua, additional, Prabhu, Sandeep, additional, Voskoboinik, Aleksandr, additional, Wong, Geoffrey R., additional, Morton, Joseph B., additional, Lee, Geoffrey, additional, Sterns, Laurence D., additional, Sanders, Prashanthan, additional, Kalman, Jonathan M., additional, and Kistler, Peter M., additional

Published
2023
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14. AB-452643-4 EFFECTS OF ADDING POSTERIOR WALL ISOLATION TO PULMONARY VEIN ISOLATION IN PERSISTENT ATRIAL FIBRILLATION AND HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)

Author

Chieng, David, primary, Sugumar, Hariharan, additional, Ling, Liang-Han, additional, Segan, Louise, additional, Al-Kaisey, Ahmed, additional, Hawson, Joshua, additional, Prabhu, Sandeep, additional, Voskoboinik, Aleksandr, additional, Wong, Geoffrey R., additional, Morton, Joseph B., additional, Lee, Geoffrey, additional, Sanders, Prashanthan, additional, Kalman, Jonathan M., additional, and Kistler, Peter M., additional

Published
2023
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15. PO-05-225 OPEN WINDOW MAPPING: COMPARATIVE COHORT STUDY

Author

Sharma, Ajay, primary, Paddock, Sophie, additional, Bangash, Fatima, additional, Lim, Wei, additional, Farwell, David J., additional, Ang, Richard, additional, Wong, Geoffrey R., additional, Garcia, Jason, additional, Papageorgiou, Nikolaos, additional, Marshall, Sophie, additional, Dulai, Rajdip S., additional, and Srinivasan, Neil T., additional

Published
2023
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16. PO-455617-16 EFFECTS OF ADDING POSTERIOR WALL ISOLATION TO PULMONARY VEIN ISOLATION IN PERSISTENT ATRIAL FIBRILLATION AND HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)

Author

Chieng, David, primary, Sugumar, Hariharan, additional, Ling, Liang-Han, additional, Segan, Louise, additional, Al-Kaisey, Ahmed, additional, Hawson, Joshua, additional, Prabhu, Sandeep, additional, Voskoboinik, Aleksandr, additional, Wong, Geoffrey R., additional, Morton, Joseph B., additional, Lee, Geoffrey, additional, Sanders, Prashanthan, additional, Kalman, Jonathan M., additional, and Kistler, Peter M., additional

Published
2023
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18. Polygenic Risk Scores are Associated with Atrial Electrophysiologic Substrate Abnormalities and Outcomes Following Atrial Fibrillation Catheter Ablation

Author

Al-Kaisey, Ahmed, primary, Wong, Geoffrey R., additional, Young, Paul, additional, Chieng, David, additional, Hawson, Joshua, additional, Anderson, Robert, additional, Sugumar, Hariharan, additional, Nalliah, Chrishan, additional, Prabhu, Mukund, additional, Johnson, Renee, additional, Soka, Magdalena, additional, Tarr, Ingrid, additional, Bakshi, Andrew, additional, Yu, Chenglong, additional, Lacaze, Paul, additional, Giannoulatou, Eleni, additional, McLellan, Alex, additional, Lee, Geoffrey, additional, Kistler, Peter M., additional, Fatkin, Diane, additional, and Kalman, Jonathan M., additional

Published
2023
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19. Polygenic risk scores are associated with atrial electrophysiologic substrate abnormalities and outcomes after atrial fibrillation catheter ablation

Author

Al-Kaisey, Ahmed, Wong, Geoffrey R., Young, Paul, Chieng, David, Hawson, Joshua, Anderson, Robert, Sugumar, Hariharan, Nalliah, Chrishan, Prabhu, Mukund, Johnson, Renee, Soka, Magdalena, Tarr, Ingrid, Bakshi, Andrew, Yu, Chenglong, Lacaze, Paul, Giannoulatou, Eleni, McLellan, Alex, Lee, Geoffrey, Kistler, Peter M., Fatkin, Diane, and Kalman, Jonathan M.

Published
2023
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22. PO-03-121 THE EFFECT OF DIAGNOSIS TO ABLATION TIME IN PATIENTS UNDERGOING CATHETER ABLATION FOR PERSISTENT ATRIAL FIBRILLATION

Author

Crowley, Rose, Chieng, David, Sugumar, Hariharan, Ling, Liang-Han, Segan, Louise, William, Jeremy, Prabhu, Sandeep, Voskoboinik, Aleksandr, Wong, Geoffrey R., Morton, Joseph B., Lee, Geoffrey, McLellan, Alex J., Wong, Michael, Pathak, Rajeev K., Sterns, Laurence D., Ginks, Matthew R., Sanders, Prashanthan, Kistler, Peter M., and Kalman, Jonathan M.

Published
2024
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23. PO-03-104 ATRIAL FIBRILLATION RECURRENCE IS MOST OFTEN PAROXYSMAL FOLLOWING CATHETER ABLATION FOR PERSISTENT ATRIAL FIBRILLATION

Author

Crowley, Rose, Chieng, David, Sugumar, Hariharan, Ling, Liang-Han, Segan, Louise, William, Jeremy, Prabhu, Sandeep, Voskoboinik, Aleksandr, Wong, Geoffrey R., Morton, Joseph B., Lee, Geoffrey, McLellan, Alex J., Wong, Michael, Pathak, Rajeev K., Sterns, Laurence D., Ginks, Matthew R., Sanders, Prashanthan, Kalman, Jonathan M., and Kistler, Peter M.

Published
2024
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24. AB-482902-002 PERSISTENT ATRIAL FIBRILLATION PHENOTYPES AND ABLATION OUTCOMES: PERSISTENT FROM THE OUTSET VS PROGRESSION FROM PAROXYSMAL

Author

Crowley, Rose, Chieng, David, Sugumar, Hariharan, Ling, Liang-Han, Segan, Louise, William, Jeremy, Prabhu, Sandeep, Voskoboinik, Aleksandr, Wong, Geoffrey R., Morton, Joseph B., Lee, Geoffrey, McLellan, Alex J., Wong, Michael, Pathak, Rajeev K., Sterns, Laurence D., Ginks, Matthew R., Sanders, Prashanthan, Kistler, Peter M., and Kalman, Jonathan M.

Published
2024
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28. Changing the view: Preventing pneumothorax during transvenous pacemaker implantation.

Author

Loudon, Brodie L. and Wong, Geoffrey R.

Subjects
*BLOOD vessels, *PNEUMOTHORAX, *DISEASES, *VENOGRAPHY, *IMPLANTABLE cardioverter-defibrillators, *MEDICAL equipment, *CARDIAC pacemakers, *LENGTH of stay in hospitals, *ELECTROPHYSIOLOGY, *FLUOROSCOPY, *DISEASE complications
Abstract

The authors discuss a study in the issue which described an analysis of employing caudal 40 degree angulation rather than conventional antero-posterior (AP) fluoroscopy to guide subclavian vein puncture for insertion of transvenous pacing wires for cardiac implantable electronic devices that shows a reduction in pneumothorax rates and use of contrast venography. Topics include main techniques for venous access, overall complication rates in the study, and retrospective nature of the study.

Published
2024
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29. Sleep apnoea has a dose-dependent effect on atrial remodelling in paroxysmal but not persistent atrial fibrillation: a high-density mapping study

Author

Nalliah, Chrishan Joseph, primary, Wong, Geoffrey R, additional, Lee, Geoffrey, additional, Voskoboinik, Aleksandr, additional, Kee, Kirk, additional, Goldin, Jeremy, additional, Watts, Troy, additional, Linz, Dominik, additional, Wirth, Daniel, additional, Parameswaran, Ramanathan, additional, Sugumar, Hariharan, additional, Prabhu, Sandeep, additional, McLellan, Alex, additional, Ling, Han, additional, Joseph, Stephen, additional, Morton, Joseph B, additional, Kistler, Peter, additional, Sanders, Prashanthan, additional, and Kalman, Jonathan M, additional

Published
2021
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32. Predicted longevity of contemporary cardiac implantable electronic devices: A call for industry-wide “standardized” reporting

Author

Munawar, Dian A., primary, Mahajan, Rajiv, additional, Linz, Dominik, additional, Wong, Geoffrey R., additional, Khokhar, Kashif B., additional, Thiyagarajah, Anand, additional, Kadhim, Kadhim, additional, Emami, Mehrdad, additional, Mishima, Ricardo, additional, Elliott, Adrian D., additional, Middeldorp, Melissa E., additional, Roberts-Thompson, Kurt C., additional, Young, Glenn D., additional, Sanders, Prashanthan, additional, and Lau, Dennis H., additional

Published
2018
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42. A narrow QRS tachycardia with changing rate: What is the mechanism(s)?

Author

Wong, Geoffrey R., Anderson, Robert D., Kalman, Jonathan M., and Prabhu, Mukund A.

Subjects
*TACHYCARDIA diagnosis, *CATHETER ablation, *ECHOCARDIOGRAPHY, *ELECTROCARDIOGRAPHY, *ELECTROPHYSIOLOGY, *HEART rate monitoring, *TACHYCARDIA
Abstract

The article presents a case study of a 15-year old girl with daily palpitations with trachycardia onset by the atrial ectopic beat. It discusses the ventriculoatrial (VA) relation, orthodromic atrioventricular reentrant tachycardia (AVRT), the results of an electrophysiological study and baseline intervals.

Published
2018
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43. Abstract 12079: Genetic Susceptibility to Atrial Fibrillation is Associated With Left Atrial Electrical Remodeling and Adverse Post-ablation Outcome

Author

Wong, Geoffrey R, Nalliah, Chrishan J, Lee, Geoffrey, Voskoboinik, Alex, Prabhu, Sandeep, Parameswaran, Ramanathan, Sugumar, Hari, Anderson, Robert, Ling, Liang-Han, Johnson, Renee, Sanders, Prashanthan, Kistler, Peter, Fatkin, Diane, and Kalman, Jonathan

Abstract

Background:Genome-wide association studies have identified a highly significant locus for AF on chromosome 4q25. However, the disease-associated phenotype remains unknown.Methods:We prospectively recruited 102 consecutive unrelated patients (aged 61 ? 9 years, 64% male) prior to AF ablation for paroxysmal or persistent AF. Subjects were genotyped for the AF-associated single nucleotide variant (SNV), rs2200733, by PCR and Sanger sequencing. High-density left atrial (LA) electroanatomic maps were created using a multipolar catheter during distal CS pacing at 600ms. Voltage, conduction velocity (CV), CV heterogeneity & fractionated signals of 6 LA segments were determined (blinded to SNV status). Long-term rhythm detection was performed by continuous device recording (51%) and serial Holter monitor (3, 6 &12 months) and 6-monthly thereafter.Results:Overall, 41 patients (40%) were SNV carriers (38 heterozygous, 3 homozygous). A mean of 2,239 ? 852 points/patient were collected. Compared with non-carriers, SNV carriers had significantly greater CV heterogeneity (45.7 ? 7.5 vs 35.9 ? 2.3%, p<0.001), complex signals (9.4 ? 2.9 vs 6.0 ? 1.2%, p=0.008), and greater regional differences in the proportion of LA with slowing or conduction block in the lateral (44.1 ? 30.9 vs 21.6 ? 30.6%, p=0.003) and posterior (41.8 ? 30.9 vs 19.1 ? 26.4%, p=0.001) walls. There were no differences in CV, voltage, atrial refractoriness or sinus node function. At median follow-up of 27 months (Q1-3: 11-28), carriers had significantly lower arrhythmia-free survival compared with non-carriers (51% vs 80%, p=0.003). On multivariate analysis, carrier status was independently associated with increased CV heterogeneity (p=0.001) and freedom from arrhythmia (p=0.019).Conclusion:These data provide the first evidence that the rs2200733 SNV haplotype predisposes to AF by effects on LA electrical remodelling and identifies this haplotype as a determinant of long term outcome.

Published
2019
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45. Sleep apnoea has a dose-dependent effect on atrial remodelling in paroxysmal but not persistent atrial fibrillation: a high-density mapping study.

Author

Nalliah CJ, Wong GR, Lee G, Voskoboinik A, Kee K, Goldin J, Watts T, Linz D, Wirth D, Parameswaran R, Sugumar H, Prabhu S, McLellan A, Ling H, Joseph S, Morton JB, Kistler P, Sanders P, and Kalman JM

Subjects
Aged, Heart Atria diagnostic imaging, Heart Atria surgery, Humans, Male, Middle Aged, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Atrial Remodeling, Catheter Ablation, Sleep Apnea, Obstructive diagnosis
Abstract

Aims: Obstructive sleep apnoea (OSA) associates with atrial fibrillation (AF), but the relationship of OSA severity and AF phenotype with the atrial substrate remains poorly defined. We sought to define the atrial substrate across the spectrum of OSA severity utilizing high-density mapping., Methods and Results: Sixty-six consecutive patients (male 71%, age 61 ± 9) having AF ablation (paroxysmal AF 36, persistent AF 30) were recruited. All patents underwent formal overnight polysomnography and high-density left atrial (LA) mapping (mean 2351 ± 1244 points) in paced rhythm. Apnoea-hypopnoea index (AHI) (mean 21 ± 18) associated with lower voltage (-0.34, P = 0.005), increased complex points (r = 0.43, P < 0.001), more low-voltage areas (r = 0.42, P < 0.001), and greater voltage heterogeneity (r = 0.39, P = 0.001), and persisted after multivariable adjustment. Atrial conduction heterogeneity (r = 0.24, P = 0.025) but not conduction velocity (r = -0.09, P = 0.50) associated with AHI. Patchy regions of low voltage that co-localized with slowed conduction defined the atrial substrate in paroxysmal AF, while a diffuse atrial substrate predominated in persistent AF. The association of AHI with remodelling was most apparent among paroxysmal AF [LA voltage: paroxysmal AF -0.015 (-0.025, -0.005), P = 0.004 vs. persistent AF -0.006 (-0.017, 0.005), P = 0.30]. Furthermore, in paroxysmal AF an AHI ≥ 30 defined a threshold at which atrial remodelling became most evident (nil-mild vs. moderate vs. severe: 1.92 ± 0.42 mV vs. 1.84 ± 0.28 mV vs. 1.34 ± 0.41 mV, P = 0.006). In contrast, significant remodelling was observed across all OSA categories in persistent AF (1.67 ± 0.55 mV vs. 1.50 ± 0.66 mV vs. 1.55 ± 0.67 mV, P = 0.82)., Conclusion: High-density mapping observed that OSA associates with marked atrial remodelling, predominantly among paroxysmal AF cohorts with severe OSA. This may facilitate the identification of AF patients that stand to derive the greatest benefit from OSA management., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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46. Defibrillator lead endocarditis.

Author

Wong GR, Roberts-Thomson RL, and Nelson AJ

Subjects
Device Removal, Diagnostic Imaging, Female, Humans, Middle Aged, Defibrillators, Implantable adverse effects, Electrodes, Implanted adverse effects, Endocarditis etiology, Endocarditis surgery, Prosthesis-Related Infections etiology, Prosthesis-Related Infections surgery
Published
2015
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