1,335 results on '"Witte, L."'
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2. Development and feasibility of a telemedicine tool for patients with recurrent urinary tract infection: myRUTIcoach
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Pat, J. J., Pape, C. C. E. T, Steffens, M. G., Witte, L. P. W., and Blanker, M. H.
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- 2023
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3. The InSight HP$^3$ mole on Mars: Lessons learned from attempts to penetrate to depth in the Martian soil
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Spohn, T., Hudson, T. L., Witte, L., Wippermann, T., Wisniewski, L., Kediziora, B., Vrettos, C., Lorenz, R. D., Golombek, M., Lichtenfeld, R., Grott, M., Knollenberg, J., Krause, C., Fantinati, C., Nagihara, S., and Grygorczuk, J.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
The NASA InSight mission payload includes the Heat Flow and Physical Properties Package HP$^3$ to measure the surface heat flow. The package was designed to use a small penetrator -- nicknamed the mole -- to implement a string of temperature sensors in the soil to a depth of 5m. The mole itself is equipped with sensors to measure a thermal conductivity as it proceeds to depth. The heat flow would be calculated from the product of the temperature gradient and the thermal conductivity. To avoid the perturbation caused by annual surface temperature variations, the measurements would be taken at a depth between 3 m and 5 m. The mole was designed to penetrate cohesionless soil similar to Quartz sand which was expected to provide a good analogue material for Martian sand. The sand would provide friction to the buried mole hull to balance the remaining recoil of the mole hammer mechanism that drives the mole forward. Unfortunately, the mole did not penetrate more than a mole length of 40 cm. The failure to penetrate deeper was largely due to a few tens of centimeter thick cohesive duricrust that failed to provide the required friction. Although a suppressor mass and spring in the hammer mechanism absorbed much of the recoil, the available mass did not allow a system that would have eliminated the recoil. The mole penetrated to 40 cm depth benefiting from friction provided by springs in the support structure from which it was deployed. It was found in addition that the Martian soil provided unexpected levels of penetration resistance that would have motivated to designing a more powerful mole. It is concluded that more mass would have allowed to design a more robust system with little or no recoil, more energy of the mole hammer mechanism and a more massive support structure., Comment: 34 pages, 15 figures, submitted to Adnaves in Space Research
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- 2021
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4. CSFIT : a FORTRAN program for charge-sheet model fitting of MOSFET data
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Witte, L. C.
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- 1985
5. Erratum bij: Acute psychiatrie
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Luykx, J. J., primary, Tijdink, J. K., additional, Vinkers, C. H., additional, and de Witte, L. D., additional
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- 2023
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6. Wvggz
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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7. Intoxicaties met hallucinogenen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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8. Juridische zaken bij minderjarigen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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9. Huiselijk geweld (inclusief kindermishandeling)
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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10. Intoxicaties met en onthouding van alcohol
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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11. Onttrekking, intoxicatie en bijwerkingen van psychofarmaca
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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12. Antidopaminerg syndroom*
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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13. Intoxicaties met en onthouding van overige dempende middelen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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14. Intoxicaties met en onthouding van GHB en GBL
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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15. Psychofarmaca in de zwangerschap en peri partum
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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16. Intoxicaties met psychostimulerende middelen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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17. Serotoninesyndroom
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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18. Acute bewegingsstoornissen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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19. Katatonie
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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20. Delirium
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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21. Paniekaanval
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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22. Depressieve episode
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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23. Manische episode
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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24. Psychotische episode
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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25. Acute agitatie
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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26. Insomnie
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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27. Functioneel neurologische uitvalsverschijnselen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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28. Eetstoornissen
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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29. Beroepsgeheim
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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30. Inleiding klinische presentaties geassocieerd met psychofarmaca
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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31. Eenzijdig opzeggen behandelingsovereenkomst; gedwongen ontslag uit kliniek
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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32. Wvggz of WGBO bij verplichte zorg?
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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33. Dwangbehandeling onder de WGBO en wilsbekwaamheid
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., Tijdink, J.K., Vinkers, C.H., and de Witte, L.D.
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- 2022
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34. Medicamenteuze behandeling van de overactieve blaas: het heden en de toekomst
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Witte, L. P. W. and Michel, Martin C.
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- 2021
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35. Aansprakelijkheid en verantwoordelijkheid
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Luykx, J. J., primary, Tijdink, J. K., additional, Vinkers, C. H., additional, and de Witte, L. D., additional
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- 2022
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36. Penetration and performance testing of the HP³ Mole for the InSight Mars mission
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Wippermann, T., Hudson, T.L., Spohn, T., Witte, L., Scharringhausen, M., Tsakyridis, G., Fittock, M., Krömer, O., Hense, S., Grott, M., Knollenberg, J., and Lichtenheldt, R.
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- 2020
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37. Erratum bij: Acute psychiatrie
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Luykx, J. J., Tijdink, J. K., Vinkers, C. H., de Witte, L. D., Luykx, J.J., editor, Tijdink, J.K., editor, Vinkers, C.H., editor, and de Witte, L.D., editor
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- 2022
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38. Characterisation of Potential Landing Sites for the European Space Agency's Lunar Lander Project
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De Rosa, D., Bussey, B., Cahill, J. T., Lutz, T., Crawford, I., Hackwill, T., van Gasselt, S., Neukum, G., Witte, L., McGovern, A., and Carpenter, J. D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
This article describes the characterization activities of the landing sites currently envisaged for the Lunar Lander mission of the European Space Agency. These sites have been identified in the South Pole Region (-85{\deg} to -90{\deg} latitude) based on favourable illumination conditions, which make it possible to have a long-duration mission with conventional power and thermal control subsystems, capable of enduring relatively short periods of darkness (in the order of tens of hours), instead of utilising Radioisotope Heating Units. The illumination conditions are simulated at the potential landing sites based on topographic data from the Lunar Orbiter Laser Altimeter (LOLA), using three independent tools. Risk assessment of the identified sites is also being performed through independent studies. Long baseline slopes are assessed based on LOLA, while craters and boulders are detected both visually and using computer tools in Lunar Reconnaissance Orbiter Camera (LROC) images, down to a size of less than 2 m, and size-frequency distributions are generated. Shadow hazards are also assessed via LROC images. The preliminary results show that areas with quasi-continuous illumination of several months exist, but their size is small (few hundred metres); the duration of the illumination period drops quickly to less than one month outside the areas, and some areas present gaps with short illumination periods. Concerning hazard distributions, 50 m slopes are found to be shallow (few degrees) based on LOLA, whereas at the scale of the lander footprint (~5 m) they are mostly dominated by craters, expected to be mature (from geological context) and shallow (~11{\deg}). The preliminary conclusion is that the environment at the prospective landing sites is within the capabilities of the Lander design.
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- 2012
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39. Anatomical features of PFO in patients with cryptogenic stroke in comparison to autopsy results
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Witte, L S, primary, Immens, M H M, additional, El Bouziani, A, additional, Duijnhouwer, A, additional, Bouma, B J, additional, De Leeuw, F E, additional, De Winter, R J, additional, and Ten Cate, T J F, additional
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- 2023
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40. OP03.08: Improving pregnancy outcome prediction in women with recurrent miscarriages by taking early ultrasound markers into account
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Habets, D., primary, de Goijer, S., additional, Witte, L., additional, and Al Nasiry, S., additional
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- 2023
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41. EFFECT OF BLADDER OUTLET PROCEDURES ON URODYNAMIC ASSESSMENTS IN MEN WITH AN ACONTRACTILE OR UNDERACTIVE DETRUSOR: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Merode van, N, primary, Nijholt, I, additional, Heesakkers, J, additional, Koeveringe, G, additional, Steffens, M, additional, and Witte, L, additional
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- 2023
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42. LONG TERM EVALUATION OF TURP IN MEN WITH DETRUSOR UNDERACTIVITY OR ACONTRACTILE DETRUSOR: A PROSPECTIVE CROSS-SECTIONAL STUDY WITH PATIENT REPORTED OUTCOMES.
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Merode van, N, primary, Meer ter, E, additional, Steffens, M, additional, and Witte, L, additional
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- 2023
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43. Assessment and treatment of recurrent urinary tract infections in women: development of a questionnaire based on a qualitative study of patient expectations in secondary care
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Pat, J. J., Aart, T. v. d., Steffens, M. G., Witte, L. P. W., and Blanker, M. H.
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- 2020
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44. New insights into the genetic etiology of Alzheimer's disease and related dementias
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Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., Yaqub, A., Prokic, I., Chapuis, J., Ahmad, S., Giedraitis, V., Aarsland, D., Garcia-Gonzalez, P., Abdelnour, C., Alarcón-Martín, E., Alcolea, D., Alegret, M., Alvarez, I., Álvarez, V., Armstrong, N. J., Tsolaki, A., Antúnez, C., Appollonio, I., Arcaro, M., Archetti, S., Pastor, A. A., Arosio, B., Athanasiu, L., Bailly, H., Banaj, N., Baquero, M., Barral, S., Beiser, A., Pastor, A. B., Below, J. E., Benchek, P., Benussi, L., Berr, C., Besse, C., Bessi, V., Binetti, G., Bizarro, A., Blesa, R., Boada, M., Boerwinkle, E., Borroni, B., Boschi, S., Bossù, P., Bråthen, G., Bressler, J., Bresner, C., Brodaty, H., Brookes, K. J., Brusco, L. I., Buiza-Rueda, D., Bûrger, K., Burholt, V., Bush, W. S., Calero, M., Cantwell, L. B., Chene, G., Chung, J., Cuccaro, M. L., Carracedo, Á., Cecchetti, R., Cervera-Carles, L., Charbonnier, C., Chen, H. -H., Chillotti, C., Ciccone, S., Claassen, J. A. H. R., Clark, C., Conti, E., Corma-Gómez, A., Costantini, E., Custodero, C., Daian, D., Dalmasso, M. C., Daniele, A., Dardiotis, E., Dartigues, J. -F., de Deyn, P. P., de Paiva Lopes, K., de Witte, L. D., Debette, S., Deckert, J., del Ser, T., Denning, N., Destefano, A., Dichgans, M., Diehl-Schmid, J., Diez-Fairen, M., Rossi, P. D., Djurovic, S., Duron, E., Düzel, E., Dufouil, C., Eiriksdottir, G., Engelborghs, S., Escott-Price, V., Espinosa, A., Ewers, M., Faber, K. M., Fabrizio, T., Nielsen, S. F., Fardo, D. W., Farotti, L., Fenoglio, C., Fernández-Fuertes, M., Ferrari, R., Ferreira, C. B., Ferri, E., Fin, B., Fischer, P., Fladby, T., Fließbach, K., Fongang, B., Fornage, M., Fortea, J., Foroud, T. M., Fostinelli, S., Fox, N. C., Franco-Macías, E., Bullido, M. J., Frank-García, A., Froelich, L., Fulton-Howard, B., Galimberti, D., García-Alberca, J. M., García-González, P., Garcia-Madrona, S., Garcia-Ribas, G., Ghidoni, R., Giegling, I., Giorgio, G., Goate, A. M., Goldhardt, O., Gomez-Fonseca, D., González-Pérez, A., Graff, C., Grande, G., Green, E., Grimmer, T., Grünblatt, E., Grunin, M., Gudnason, V., Guetta-Baranes, T., Haapasalo, A., Hadjigeorgiou, G., Haines, J. L., Hamilton-Nelson, K. L., Hampel, H., Hanon, O., Hardy, J., Hartmann, A. M., Hausner, L., Harwood, J., Heilmann-Heimbach, S., Helisalmi, S., Heneka, M. T., Hernández, I., Herrmann, M. J., Hoffmann, P., Holmes, C., Holstege, H., Vilas, R. H., Hulsman, M., Humphrey, J., Biessels, G. J., Jian, X., Johansson, C., Jun, G. R., Kastumata, Y., Kauwe, J., Kehoe, P. G., Kilander, L., Ståhlbom, A. K., Kivipelto, M., Koivisto, A., Kornhuber, J., Kosmidis, M. H., Kukull, W. A., Kuksa, P. P., Kunkle, B. W., Kuzma, A. B., Lage, C., Laukka, E. J., Launer, L., Lauria, A., Lee, C. -Y., Lehtisalo, J., Lerch, O., Lleó, A., Longstreth, W., Lopez, O., de Munain, A. L., Love, S., Löwemark, M., Luckcuck, L., Lunetta, K. L., Ma, Y., Macías, J., Macleod, C. A., Maier, W., Mangialasche, F., Spallazzi, M., Marquié, M., Marshall, R., Martin, E. R., Montes, A. M., Rodríguez, C. M., Masullo, C., Mayeux, R., Mead, S., Mecocci, P., Medina, M., Meggy, A., Mehrabian, S., Mendoza, S., Menéndez-González, M., Mir, P., Moebus, S., Mol, M., Molina-Porcel, L., Montrreal, L., Morelli, L., Moreno, F., Morgan, K., Mosley, T., Nöthen, M. M., Muchnik, C., Mukherjee, S., Nacmias, B., Ngandu, T., Nicolas, G., Nordestgaard, B. G., Olaso, R., Orellana, A., Orsini, M., Ortega, G., Padovani, A., Paolo, C., Papenberg, G., Parnetti, L., Pasquier, F., Pastor, P., Peloso, G., Pérez-Cordón, A., Pérez-Tur, J., Pericard, P., Peters, O., Pijnenburg, Y. A. L., Pineda, J. A., Piñol-Ripoll, G., Pisanu, C., Polak, T., Popp, J., Posthuma, D., Priller, J., Puerta, R., Quenez, O., Quintela, I., Thomassen, J. Q., Rábano, A., Rainero, I., Rajabli, F., Ramakers, I., Real, L. M., Reinders, M. J. T., Reitz, C., Reyes-Dumeyer, D., Ridge, P., Riedel-Heller, S., Riederer, P., Roberto, N., Rodriguez-Rodriguez, E., Rongve, A., Allende, I. R., Rosende-Roca, M., Royo, J. L., Rubino, E., Rujescu, D., Sáez, M. E., Sakka, P., Saltvedt, I., Sanabria, Á., Sánchez-Arjona, M. B., Sanchez-Garcia, F., Juan, P. S., Sánchez-Valle, R., Sando, S. B., Sarnowski, C., Satizabal, C. L., Scamosci, M., Scarmeas, N., Scarpini, E., Scheltens, P., Scherbaum, N., Scherer, M., Schmid, M., Schneider, A., Schott, J. M., Selbæk, G., Seripa, D., Serrano, M., Sha, J., Shadrin, A. A., Skrobot, O., Slifer, S., Snijders, G. J. L., Soininen, H., Solfrizzi, V., Solomon, A., Song, Y. E., Sorbi, S., Sotolongo-Grau, O., Spalletta, G., Spottke, A., Squassina, A., Stordal, E., Tartan, J. P., Tárraga, L., Tesí, N., Thalamuthu, A., Thomas, T., Tosto, G., Traykov, L., Tremolizzo, L., Tybjærg-Hansen, A., Uitterlinden, A., Ullgren, A., Ulstein, I., Valero, S., Valladares, O., Broeckhoven, C. V., Vance, J., Vardarajan, B. N., van der Lugt, A., Dongen, J. V., van Rooij, J., van Swieten, J., Vandenberghe, R., Verhey, F., Vidal, J. -S., Vogelgsang, J., Vyhnalek, M., Wagner, M., Wallon, D., Wang, L. -S., Wang, R., Weinhold, L., Wiltfang, J., Windle, G., Woods, B., Yannakoulia, M., Zare, H., Zhao, Y., Zhang, X., Zhu, C., Zulaica, M., Laczo, J., Matoska, V., Serpente, M., Assogna, F., Piras, F., Ciullo, V., Shofany, J., Ferrarese, C., Andreoni, S., Sala, G., Zoia, C. P., Zompo, M. D., Benussi, A., Bastiani, P., Takalo, M., Natunen, T., Laatikainen, T., Tuomilehto, J., Antikainen, R., Strandberg, T., Lindström, J., Peltonen, M., Abraham, R., Al-Chalabi, A., Bass, N. J., Brayne, C., Brown, K. 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M, Humphrey, J, Biessels, G, Jian, X, Johansson, C, Jun, G, Kastumata, Y, Kauwe, J, Kehoe, P, Kilander, L, Ståhlbom, A, Kivipelto, M, Koivisto, A, Kornhuber, J, Kosmidis, M, Kukull, W, Kuksa, P, Kunkle, B, Kuzma, A, Lage, C, Laukka, E, Launer, L, Lauria, A, Lee, C, Lehtisalo, J, Lerch, O, Lleó, A, Longstreth, W, Lopez, O, de Munain, A, Love, S, Löwemark, M, Luckcuck, L, Lunetta, K, Ma, Y, Macías, J, Macleod, C, Maier, W, Mangialasche, F, Spallazzi, M, Marquié, M, Marshall, R, Martin, E, Montes, A, Rodríguez, C, Masullo, C, Mayeux, R, Mead, S, Mecocci, P, Medina, M, Meggy, A, Mehrabian, S, Mendoza, S, Menéndez-González, M, Mir, P, Moebus, S, Mol, M, Molina-Porcel, L, Montrreal, L, Morelli, L, Moreno, F, Morgan, K, Mosley, T, Nöthen, M, Muchnik, C, Mukherjee, S, Nacmias, B, Ngandu, T, Nicolas, G, Nordestgaard, B, Olaso, R, Orellana, A, Orsini, M, Ortega, G, Padovani, A, Paolo, C, Papenberg, G, Parnetti, L, Pasquier, F, Pastor, P, Peloso, G, Pérez-Cordón, A, Pérez-Tur, J, Pericard, P, 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[0000-0002-7542-1139], Kornhuber, Johannes [0000-0002-8096-3987], Kosmidis, Mary H [0000-0001-8790-1220], Lage, Carmen [0000-0003-1703-121X], Launer, Lenore [0000-0002-3238-7612], Lee, Chien-Yueh [0000-0002-4304-974X], Lleó, Alberto [0000-0002-2568-5478], Lopez, Oscar [0000-0002-8546-8256], de Munain, Adolfo Lopez [0000-0002-9509-4032], Lunetta, Kathryn L [0000-0002-9268-810X], Ma, Yiyi [0000-0002-3609-8877], MacLeod, Catherine A [0000-0002-9314-7380], Marquié, Marta [0000-0002-0660-0950], Montes, Angel Martín [0000-0002-1694-786X], Mead, Simon [0000-0002-4326-1468], Medina, Miguel [0000-0002-7016-5340], Menéndez-González, Manuel [0000-0002-5218-0774], Mol, Merel [0000-0003-2533-2530], Morgan, Kevin [0000-0002-8217-2396], Nöthen, Markus M [0000-0002-8770-2464], Muchnik, Carolina [0000-0002-1542-3706], Nacmias, Benedetta [0000-0001-9338-9040], Nicolas, Gael [0000-0001-9391-7800], Nordestgaard, Børge G [0000-0002-1954-7220], Pasquier, Florence [0000-0001-9880-9788], Pastor, Pau [0000-0002-7493-8777], Peloso, Gina [0000-0002-5355-8636], Pérez-Cordón, Alba [0000-0002-6028-0791], Pérez-Tur, Jordi [0000-0002-9111-1712], Pericard, Pierre [0000-0001-8167-6448], Pineda, Juan A [0000-0002-3751-0296], Pisanu, Claudia [0000-0002-9151-4319], Posthuma, Danielle [0000-0001-7582-2365], Puerta, Raquel [0000-0002-1191-5893], Quenez, Olivier [0000-0002-8273-8505], Thomassen, Jesper Qvist [0000-0003-3484-9531], Real, Luis M [0000-0003-4932-7429], Reinders, Marcel JT [0000-0002-1148-1562], Reitz, Christiane [0000-0001-8757-7889], Riedel-Heller, Steffi [0000-0003-4321-6090], Rodriguez-Rodriguez, Eloy [0000-0001-7742-677X], Rongve, Arvid [0000-0002-0476-4134], Sáez, María Eugenia [0000-0001-9299-2534], Saltvedt, Ingvild [0000-0002-7897-9808], Juan, Pascual Sánchez [0000-0002-6081-8037], Sarnowski, Chloé [0000-0002-6090-7099], Satizabal, Claudia L [0000-0002-1115-4430], Schott, Jonathan M [0000-0003-2059-024X], Selbæk, Geir [0000-0001-6511-8219], Shadrin, Alexey A [0000-0002-7467-250X], Soininen, Hilkka [0000-0002-2785-9937], Solfrizzi, Vincenzo [0000-0002-8524-0315], Song, Yeunjoo [0000-0002-7452-3731], Sotolongo-Grau, Oscar [0000-0002-9679-0670], Spalletta, Gianfranco [0000-0002-7432-4249], Squassina, Alessio [0000-0001-7415-7607], Stordal, Eystein [0000-0002-2443-7923], Tosto, Giuseppe [0000-0001-7075-8245], Uitterlinden, Andre [0000-0002-7276-3387], Valladares, Otto [0000-0001-8055-2187], Broeckhoven, Christine Van [0000-0003-0183-7665], Vidal, Jean-Sébastien [0000-0001-6770-0720], Vogelgsang, Jonathan [0000-0001-9326-8193], Wagner, Michael [0000-0003-2589-6440], Wallon, David [0000-0002-2634-7198], Wiltfang, Jens [0000-0003-1492-5330], Woods, Bob [0000-0002-6781-651X], Yannakoulia, Mary [0000-0003-2171-7337], Zare, Habil [0000-0001-5902-6238], Zhang, Xiaoling [0000-0001-8237-1857], Farrer, Lindsay A [0000-0001-5533-4225], Psaty, Bruce M [0000-0002-7278-2190], Ghanbari, Mohsen [0000-0002-9476-7143], Raj, Towfique [0000-0002-9355-5704], Sachdev, Perminder [0000-0002-9595-3220], Mather, Karen [0000-0003-4143-8941], Ikram, M Arfan [0000-0003-0372-8585], Tsolaki, Magda [0000-0002-2072-8010], Pericak-Vance, Margaret A [0000-0001-7283-8804], Amouyel, Philippe [0000-0001-9088-234X], Williams, Julie [0000-0002-4069-0259], Frikke-Schmidt, Ruth [0000-0003-4084-5027], Seshadri, Sudha [0000-0001-6135-2622], Andreassen, Ole A [0000-0002-4461-3568], Sleegers, Kristel [0000-0002-0283-2332], van Duijn, Cornelia M [0000-0002-2374-9204], Sims, Rebecca [0000-0002-3885-1199], van der Flier, Wiesje M [0000-0001-8766-6224], Ramirez, Alfredo [0000-0003-4991-763X], Lambert, Jean-Charles [0000-0003-0829-7817], Apollo - University of Cambridge Repository, Complex Trait Genetics, Clinical sciences, Neuroprotection & Neuromodulation, Pathologic Biochemistry and Physiology, Clinical Biology, Epidemiology, Internal Medicine, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), UAM. Departamento de Biología Molecular, University of Helsinki, Department of Neurosciences, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, HUS Neurocenter, Neurologian yksikkö, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (France), European Commission, LabEx DISTALZ, Pérez-Tur, Jordi, University Children’s Hospital Basel (Suiza), INSERM (Francia), Lille Métropole Communauté Urbaine, Government of France (Francia), EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Holmans, Peter A. [0000-0003-0870-9412], van der Lee, Sven J. [0000-0003-1606-8643], Costa, Marcos R. [0000-0002-4928-2163], Bis, Joshua C. [0000-0002-3409-1110], Brookes, Keeley J. [0000-0003-2427-2513], Bush, William S. [0000-0002-9729-6519], de Witte, Lot D. [0000-0002-7235-9958], del Ser, Teodoro [0000-0001-9806-7083], Fox, Nick C. [0000-0002-6660-657X], Bullido, María J. [0000-0002-6477-1117], Goate, Alison M. [0000-0002-0576-2472], Herrmann, Martin J. [0000-0001-9970-2122], Jun, Gyungah R. [0000-0002-3230-8697], Kehoe, Patrick G. [0000-0002-7542-1139], Kosmidis, Mary H. [0000-0001-8790-1220], Lunetta, Kathryn L. [0000-0002-9268-810X], MacLeod, Catherine A. [0000-0002-9314-7380], Nöthen, Markus M. [0000-0002-8770-2464], Nordestgaard, Børge G. [0000-0002-1954-7220], Pineda, Juan A. [0000-0002-3751-0296], Real, Luis M. [0000-0003-4932-7429], Reinders, Marcel J. T. [0000-0002-1148-1562], Satizabal, Claudia L. [0000-0002-1115-4430], Schott, Jonathan M. [0000-0003-2059-024X], Shadrin, Alexey A. [0000-0002-7467-250X], Farrer, Lindsay A. [0000-0001-5533-4225], Psaty, Bruce M. [0000-0002-7278-2190], Ikram, M. Arfan [0000-0003-0372-8585], Pericak-Vance, Margaret A. [0000-0001-7283-8804], Andreassen, Ole A. [0000-0002-4461-3568], van Duijn, Cornelia M. [0000-0002-2374-9204], van der Flier, Wiesje M. [0000-0001-8766-6224], and Molecular Neuroscience and Ageing Research (MOLAR)
- Subjects
tau Proteins/genetics ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,Neurologi ,MED/03 - GENETICA MEDICA ,45/43 ,Medizin ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,genetics [Alzheimer Disease] ,Genome-Wide Association Study ,Humans ,tau Proteins ,Alzheimer Disease ,Cognitive Dysfunction ,VARIANTS ,pathology [Alzheimer Disease] ,Tau Proteins ,Settore BIO/13 - Biologia Applicata ,Cognitive Dysfunction/psychology ,692/699/375/365/1283 ,IMPUTATION ,article ,1184 Genetics, developmental biology, physiology ,Biología y Biomedicina / Biología ,AMYLOID-BETA ,Settore MED/26 - NEUROLOGIA ,Neurology ,psychology [Cognitive Dysfunction] ,Medical Genetics ,Human ,Neuroscience(all) ,631/208/205/2138 ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,ddc:570 ,Genetics ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,Medicinsk genetik ,MED/26 - NEUROLOGIA ,Alzheimer Disease/genetics ,neurology ,tau Protein ,NECROSIS-FACTOR-ALPHA ,RISK LOCI ,genetics [tau Proteins] ,PREDICTION MODELS ,Human medicine ,GENERATION ,RESPONSES - Abstract
25 páginas, 6 figuras, 2 tablas, Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele., This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Full consortium acknowledgements and funding are in the Supplementary Not
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- 2022
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45. A seismic-network mission proposal as an example for modular robotic lunar exploration missions
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Lange, C., Witte, L., Rosta, R., Sohl, F., Heffels, A., and Knapmeyer, M.
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- 2017
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46. The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies
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Snijders, G., de Witte, L., Mesman, E., Kemner, S., Vonk, R., Brouwer, R., Nolen, W. A., Drexhage, H. A., and Hillegers, M. H. J.
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- 2017
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47. Development and feasibility of a telemedicine tool for patients with recurrent urinary tract infection:myRUTIcoach
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Pat, J. J., Pape, C. C.E.T., Steffens, M. G., Witte, L. P.W., Blanker, M. H., Pat, J. J., Pape, C. C.E.T., Steffens, M. G., Witte, L. P.W., and Blanker, M. H.
- Abstract
Introduction and hypothesis: Patients with recurrent urinary tract infection (rUTI) have limited knowledge of preventive strategies to lower the risk of UTI. We aimed to develop and test the feasibility of an eHealth system for women with rUTI, named myRUTIcoach, and explored the facilitators and barriers related to its adoption. Methods: We developed myRUTIcoach in a structured iterative process and tested its feasibility among 25 women with rUTI over 2 months. Subsequent questionnaires covered satisfaction, accessibility, and experiences with myRUTIcoach. A random selection of participants and relevant stakeholders took part in semi-structured interviews to explore adoption. Data were analyzed and elaborated using inductive and deductive approaches using the Non-adoption, Abandonment, Spread, Scale-up, and Sustainability (NASSS) framework. Results: MyRUTIcoach was not only widely accepted but also facilitated communication with health care professionals (HCPs) and contributed to greater knowledge of rUTI. Women graded the system a mean of 8.0 (±0.6) out of 10, with 89% stating that they would recommend it to others. Patients indicated that self-management skills were the major facilitators and barriers related to adoption, whereas HCPs stated that the disconnect between myRUTIcoach and electronic health care records (EHRs) was the major barrier. Conclusions: This research describes the development and testing of myRUTIcoach for women with rUTI. Patients and HCPs reported high satisfaction and compliance with myRUTIcoach. However, adoption by the intended users is complex and influenced by all examined domains of the NASSS framework. We have already improved linkage to EHRs, but further optimization to meet patient needs may improve the effectiveness of this self-management tool for rUTI.
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- 2023
48. Process evaluation of physical activity counselling with and without the use of mobile technology: A mixed methods study
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Verwey, R., van der Weegen, S., Spreeuwenberg, M., Tange, H., van der Weijden, T., and de Witte, L.
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- 2016
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49. 197 - LONG TERM EVALUATION OF TURP IN MEN WITH DETRUSOR UNDERACTIVITY OR ACONTRACTILE DETRUSOR: A PROSPECTIVE CROSS-SECTIONAL STUDY WITH PATIENT REPORTED OUTCOMES.
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Merode van, N, Meer ter, E, Steffens, M, and Witte, L
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- 2023
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50. 11 - EFFECT OF BLADDER OUTLET PROCEDURES ON URODYNAMIC ASSESSMENTS IN MEN WITH AN ACONTRACTILE OR UNDERACTIVE DETRUSOR: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Merode van, N, Nijholt, I, Heesakkers, J, Koeveringe, G, Steffens, M, and Witte, L
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- 2023
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