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2. Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic

Author

Zeller, Ivo, Weiss, Andreas, Arnolds, Stefanie, Schütte-Borkovec, Katharina, Arabi, Sari, von dem Berge, Thekla, Casteels, Kristina, Hommel, Angela, Kordonouri, Olga, Larsson, Helena Elding, Lundgren, Markus, Rochtus, Anne, Snape, Matthew D., Szypowka, Agnieszka, Vatish, Manu, Winkler, Christiane, Bonifacio, Ezio, and Ziegler, Anette-Gabriele

Published
2024
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3. Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes

Author

Hummel, Sandra, Rosenberger, Sarah, von dem Berge, Thekla, Besser, Rachel E. J., Casteels, Kristina, Hommel, Angela, Kordonouri, Olga, Elding Larsson, Helena, Lundgren, Markus, Marcus, Benjamin A., Oltarzewski, Mariusz, Rochtus, Anne, Szypowska, Agnieszka, Todd, John A., Weiss, Andreas, Winkler, Christiane, Bonifacio, Ezio, and Ziegler, Anette-G.

Published
2024
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4. Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation

Author

Hummel, Sandra, Carl, Johanna, Friedl, Nadine, Winkler, Christiane, Kick, Kerstin, Stock, Joanna, Reinmüller, Franziska, Ramminger, Claudia, Schmidt, Jennifer, Lwowsky, Dominik, Braig, Sonja, Dunstheimer, Desiree, Ermer, Uwe, Gerstl, Eva-Maria, Weber, Leonie, Nellen-Hellmuth, Nicole, Brämswig, Susanne, Sindichakis, Marina, Tretter, Stefanie, Lorrmann, Anja, Bonifacio, Ezio, Ziegler, Anette-G., and Achenbach, Peter

Published
2023
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9. Data-Driven Phenotyping of Presymptomatic Type 1 Diabetes Using Longitudinal Autoantibody Profiles.

Author

Ghalwash, Mohamed, Anand, Vibha, Ng, Kenney, Dunne, Jessica L., Lou, Olivia, Lundgren, Markus, Hagopian, William A., Rewers, Marian, Ziegler, Anette-G., Veijola, Riitta, Ziegler, Anette G., Bonifacio, Ezio, Achenbach, Peter, Winkler, Christiane, Frohnert, Brigitte I., Norris, Jill, Steck, Andrea, Waugh, Kathleen, Yu, Liping, and Killian, Michael

Subjects
TYPE 1 diabetes, AUTOANTIBODIES, HIERARCHICAL clustering (Cluster analysis), SURVIVAL analysis (Biometry), SEROCONVERSION
Abstract

OBJECTIVE: To characterize distinct islet autoantibody profiles preceding stage 3 type 1 diabetes RESEARCH DESIGN AND METHODS: The T1DI (Type 1 Diabetes Intelligence) study combined data from 1,845 genetically susceptible prospectively observed children who were positive for at least one islet autoantibody: insulin autoantibody (IAA), GAD antibody (GADA), or islet antigen 2 antibody (IA-2A). Using a novel similarity algorithm that considers an individual's temporal autoantibody profile, age at autoantibody appearance, and variation in the positivity of autoantibody types, we performed an unsupervised hierarchical clustering analysis. Progression rates to diabetes were analyzed via survival analysis. RESULTS: We identified five main clusters of individuals with distinct autoantibody profiles characterized by seroconversion age and sequence of appearance of the three autoantibodies. The highest 5-year risk from first positive autoantibody to type 1 diabetes (69.9%; 95% CI 60.0–79.2) was observed in children who first developed IAA in early life (median age 1.6 years) followed by GADA (1.9 years) and then IA-2A (2.1 years). Their 10-year risk was 89.9% (95% CI 81.9–95.4). A high 5-year risk was also found in children with persistent IAA and GADA (39.1%) and children with persistent GADA and IA-2A (30.9%). A lower 5-year risk (10.5%) was observed in children with a late appearance of persistent GADA (6.1 years). The lowest 5-year diabetes risk (1.6%) was associated with positivity for a single, often reverting, autoantibody. CONCLUSIONS: The novel clustering algorithm identified children with distinct islet autoantibody profiles and progression rates to diabetes. These results are useful for prediction, selection of individuals for prevention trials, and studies investigating various pathways to type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Flexible Bayesian additive joint models with an application to type 1 diabetes research

Author

Köhler, Meike, Umlauf, Nikolaus, Beyerlein, Andreas, Winkler, Christiane, Ziegler, Anette-Gabriele, and Greven, Sonja

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

The joint modeling of longitudinal and time-to-event data is an important tool of growing popularity to gain insights into the association between a biomarker and an event process. We develop a general framework of flexible additive joint models that allows the specification of a variety of effects, such as smooth nonlinear, time-varying and random effects, in the longitudinal and survival parts of the models. Our extensions are motivated by the investigation of the relationship between fluctuating disease-specific markers, in this case autoantibodies, and the progression to the autoimmune disease type 1 diabetes. By making use of Bayesian P-splines we are in particular able to capture highly nonlinear subject-specific marker trajectories as well as a time-varying association between the marker and the event process allowing new insights into disease progression. The model is estimated within a Bayesian framework and implemented in the R-package bamlss.

Published
2016

12. Feasibility and organization of a population-based screening for pre-symptomatic type 1 diabetes in children — evaluation of the Fr1da study

Author

Kick, Kerstin, Hoffmann, Verena S., Lange, Karin, Lang, Martin, Laub, Otto, Bechtold-Dalla Pozza, Susanne, Böcker, Dominik, Braig, Sonja, Dietz, Brigitte, Dunstheimer, Desiree, Eber, Stefan, Ermer, Uwe, Gavazzeni, Antonia, Gerstl, Eva-Maria, Götz, Martin, Huhn, Friederike, Kuhnle-Krahl, Ursula, Landendörfer, Wolfgang, Leipold, Georg, Leppik, Karl-Heinz, Müller, Herbert, Müller, Iris, Nellen-Hellmuth, Nicole, Ockert, Christian, Renner, Christian, Sindichakis, Marina, Tretter, Stefanie, Warncke, Katharina, Winkler, Christiane, Zeller, Stefan, Achenbach, Peter, and Ziegler, Anette-Gabriele

Published
2019
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13. Epigenome–wide Meta–Analysis Reveals Associations between Dietary Glycemic Index and Glycemic Load and DNA methylation in Children and Adolescents with Different Body Size

Author

Ott, Raffael, primary, Stein, Robert, primary, H. Hauta–alus, Helena, primary, Ronkainen, Justiina, primary, Fernández-Barrés, Sílvia, primary, Spielau, Ulrike, primary, Kirsten, Holger, primary, Poulain, Tanja, primary, Melton, Phillip E., primary, Küpers, Leanne K., primary, Azaryah, Hatim, primary, Colombo, Marco, primary, Landgraf, Kathrin, primary, W. Tob, Elmar, primary, O’Sullivan, Therese, primary, Huang, Rae-Chi, primary, Campoy, Cristina, primary, Winkler, Christiane, primary, Vioque, Jesus, primary, Vrijheid, Martine, primary, Kiess, Wieland, primary, Körner, Antje, primary, Sebert, Sylvain, primary, Jarvelin, Marjo-Riitta, primary, Ziegler, Anette G., primary, and Hummel, Sandra, primary

Published
2023
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14. Epigenome-Wide Meta-Analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes

Author

Ott, Raffael, primary, Stein, Robert, additional, Hauta–alus, Helena H., additional, Ronkainen, Justiina, additional, Fernández–Barrés, Sílvia, additional, Spielau, Ulrike, additional, Kirsten, Holger, additional, Poulain, Tanja, additional, Melton, Phillip E., additional, Küpers, Leanne K., additional, Azaryah, Hatim, additional, Colombo, Marco, additional, Landgraf, Kathrin, additional, Tobi, Elmar W., additional, O’Sullivan, Therese, additional, Huang, Rae-Chi, additional, Campoy, Cristina, additional, Winkler, Christiane, additional, Vioque, Jesus, additional, Vrijheid, Martine, additional, Kiess, Wieland, additional, Körner, Antje, additional, Sebert, Sylvain, additional, Jarvelin, Marjo-Riitta, additional, Ziegler, Anette–G., additional, and Hummel, Sandra, additional

Published
2023
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19. Refining the Definition of Stage 1 Type 1 Diabetes: An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity.

Author

Frohnert, Brigitte I., Ghalwash, Mohamed, Li, Ying, Ng, Kenney, Dunne, Jessica L., Lundgren, Markus, Hagopian, William, Lou, Olivia, Winkler, Christiane, Toppari, Jorma, Veijola, Riitta, Anand, Vibha, Ziegler, Anette G., Bonifacio, Ezio, Achenbach, Peter, Rewers, Marian, Norris, Jill, Steck, Andrea, Waugh, Kathleen, and Yu, Liping

Subjects
TYPE 1 diabetes, AUTOIMMUNITY, ISLANDS, AUTOANTIBODIES, HETEROGENEITY
Abstract

OBJECTIVE: To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS: Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddlers enrolled by age 2.5 years and comparison between groups using Kaplan-Meier survival analysis. RESULTS: Of 865 (5%) children with mIA, 537 (62%) progressed to type 1 diabetes. The 15-year cumulative incidence of diabetes varied from the most stringent definition (mIA/Persistent/2: two or more islet autoantibodies positive at the same visit with two or more antibodies persistent at next visit; 88% [95% CI 85–92%]) to the least stringent (mIA/Any: positivity for two islet autoantibodies without co-occurring positivity or persistence; 18% [5–40%]). Progression in mIA/Persistent/2 was significantly higher than all other groups (P < 0.0001). Intermediate stringency definitions showed intermediate risk and were significantly different than mIA/Any (P < 0.05); however, differences waned over the 2-year follow-up among those who did not subsequently reach higher stringency. Among mIA/Persistent/2 individuals with three autoantibodies, loss of one autoantibody by the 2-year follow-up was associated with accelerated progression. Age was significantly associated with time from seroconversion to mIA/Persistent/2 status and mIA to stage 3 type 1 diabetes. CONCLUSIONS: The 15-year risk of progression to type 1 diabetes risk varies markedly from 18 to 88% based on the stringency of mIA definition. While initial categorization identifies highest-risk individuals, short-term follow-up over 2 years may help stratify evolving risk, especially for those with less stringent definitions of mIA. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study

Author

Ghalwash, Mohamed, primary, Anand, Vibha, additional, Lou, Olivia, additional, Martin, Frank, additional, Rewers, Marian, additional, Ziegler, Anette-G, additional, Toppari, Jorma, additional, Hagopian, William A, additional, Veijola, Riitta, additional, Achenbach, Peter, additional, Bonifacio, Ezio, additional, Crouch, Claire, additional, Dunne, Jessica, additional, Elding Larsson, Helena, additional, Frohnert, Brigitte I, additional, Hu, Jianying, additional, Hyöty, Heikki, additional, Ilonen, Jorma, additional, Jönsson, Josefin, additional, Killian, Michael, additional, Knip, Mikael, additional, Koski, Eileen, additional, Lernmark, Åke, additional, Li, Ying, additional, Li, Zhiguo, additional, Liu, Bin, additional, Lundgren, Markus, additional, Malhotra, Ashwani, additional, Maziarz, Marlena, additional, Meyer, Jocelyn, additional, Moore, Shelley, additional, Ng, Kenney, additional, Norris, Jill, additional, Roy, Shreya, additional, Spiliopoulos, Lampros, additional, Steck, Andrea, additional, Stavropoulos, Harry, additional, Waugh, Kathleen, additional, Winkler, Christiane, additional, and Yu, Liping, additional

Published
2023
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24. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort

Author

Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Foghis, Gabriela, Anderson, Stephen W., Robinson, Richard, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Stock, Joanna, Strauss, Elisabeth, Warncke, Katharina, Winkler, Christiane, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Kähönen, Miia, Knip, Mikael, Koivu, Annika, Koreasalo, Mirva, Kurppa, Kalle, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Romo, Minna, Simell, Satu, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Särmä, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lernmark, Åke, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Harmby, Cecilia, Hyberg, Susanne, Johansen, Fredrik, Jonasdottir, Berglind, Larsson, Helena Elding, Forss, Sigrid Lenrick, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Rahmati, Kobra, Ramelius, Anita, Rosenquist, Anna, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Trulsson, Erika, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Ayres, Stephen, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Scott, Elizabeth, Stabbert, Joshua, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, McLeod, Wendy, Meulemans, Steven, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, Andrén Aronsson, Carin, and Norris, Jill M.

Published
2016
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26. Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study

Author

Köhler, Meike, Beyerlein, Andreas, Vehik, Kendra, Greven, Sonja, Umlauf, Nikolaus, Lernmark, Åke, Hagopian, William A., Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Krischer, Jeffrey P., Bonifacio, Ezio, Ziegler, Anette-G., Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lindfors, Katri, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W., Jacobsen, Laura, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Lernmark, Åke, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Lindström, Marielle, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, PerezLaras, Francisco, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, McLeod, Wendy, Akolkar, Beena, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire, Wyatt, Rebecca, George, Gifty, Grace, Sian, Erlich, Henry, Mack, Steven J., Ke, Sandra, Mulholland, Niveen, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, TEDDY study group, Ancillary Studies, Diet, Genetics, Human Subjects/Publicity/Publications, Immune Markers, Infectious Agents, Laboratory Implementation, Maternal Studies, Psychosocial, Quality Assurance, Steering, Study Coordinators, Celiac Disease, Clinical Implementation, and Quality Assurance Subcommittee on Data Quality

Published
2017
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28. Progression From Presymptomatic to Clinical Type 1 Diabetes After COVID-19 Infection.

Author

Friedl, Nadine, Sporreiter, Melanie, Winkler, Christiane, Heublein, Anja, Haupt, Florian, Ziegler, Anette-Gabriele, and Bonifacio, Ezio

Subjects
TYPE 1 diabetes, COVID-19, DISEASE progression
Abstract

This study examines whether an association exists between COVID-19 infection and progression to clinical diabetes among youth with presymptomatic type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Birth Justice – Intersektionale Perspektiven auf die Begleitung von Schwangerschaft, Geburt und früher Elternschaft

Author

Winkler, Christiane and Babac, Emine

Subjects
Birth Justice, Medicine and health, Reproduktive Gerechtigkeit, reproductive justice, Intersektionalität, obstetric violence, intersectionality, Diskriminierung, discrimination, Gewalt in der Geburtshilfe
Abstract

Hintergrund: Die parlamentarische Versammlung des Europarates ordnete Gewalt in der Geburtshilfe als genderspezifische Gewaltform ein und stellte dringenden Handlungsbedarf in allen Mitgliedsstaaten fest. Sie forderte u.a. dazu auf, Diskriminierung beim Zugang zur Gesundheitsversorgung zu bekämpfen [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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30. Intersektionalität und Diversität in der Hebammenwissenschaft – Potentiale und Herausforderungen

Author

Winkler, Christiane and Babac, Emine

Subjects
Birth Justice, Medicine and health, Reproduktive Gerechtigkeit, reproductive justice, Intersektionalität, intersectionality, Diskriminierung, discrimination
Abstract

Hintergrund: Die individuellen Erfahrungen Schwangerer* und Gebärender* werden geprägt durch die vielfältigen Wechselwirkungen zwischen Merkmalen wie geschlechtlicher Identität, „Rasse“/Ethnizität/Nationalität, Klasse, Alter, sog. Behinderung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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31. Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials

Author

Bendor-Samuel, Owen Martyn, primary, Wishlade, Tabitha, additional, Willis, Louise, additional, Aley, Parvinder, additional, Choi, Edward, additional, Craik, Rachel, additional, Mujadidi, Yama, additional, Mounce, Ginny, additional, Roseman, Fenella, additional, De La Horra Gozalo, Arancha, additional, Bland, James, additional, Taj, Nazia, additional, Smith, Ian, additional, Ziegler, Anette-Gabriele, additional, Bonifacio, Ezio, additional, Winkler, Christiane, additional, Haupt, Florian, additional, Todd, John A, additional, Servais, Laurent, additional, Snape, Matthew D, additional, and Vatish, Manu, additional

Published
2022
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40. Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials.

Author

Bendor-Samuel, Owen Martyn, Wishlade, Tabitha, Willis, Louise, Aley, Parvinder, Choi, Edward, Craik, Rachel, Mujadidi, Yama, Mounce, Ginny, Roseman, Fenella, Gozalo, Arancha De La Horra, Bland, James, Taj, Nazia, Smith, Ian, Ziegler, Anette-Gabriele, Bonifacio, Ezio, Winkler, Christiane, Haupt, Florian, Todd, John A., Servais, Laurent, and Snape, Matthew D.

Subjects
GENETIC testing, MEDICAL screening, NEWBORN infants, CLINICAL trials, TYPE 1 diabetes, HIV seroconversion, PEANUT allergy
Published
2023
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42. Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes

Author

Li, Zhiguo, primary, Veijola, Riitta, additional, Koski, Eileen, additional, Anand, Vibha, additional, Martin, Frank, additional, Waugh, Kathleen, additional, Hyöty, Heikki, additional, Winkler, Christiane, additional, Killian, Michael B, additional, Lundgren, Markus, additional, Ng, Kenney, additional, Maziarz, Marlena, additional, and Toppari, Jorma, additional

Published
2022
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43. Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Author

Tobi, Elmar W., primary, Juvinao-Quintero, Diana L., additional, Ronkainen, Justiina, additional, Ott, Raffael, additional, Alfano, Rossella, additional, Canouil, Mickaël, additional, Geurtsen, Madelon L., additional, Khamis, Amna, additional, Küpers, Leanne K., additional, Lim, Ives Y., additional, Perron, Patrice, additional, Pesce, Giancarlo, additional, Tuhkanen, Johanna, additional, Starling, Anne P., additional, Andrew, Toby, additional, Binder, Elisabeth, additional, Caiazzo, Robert, additional, Chan, Jerry K.Y., additional, Gaillard, Romy, additional, Gluckman, Peter D., additional, Keikkala, Elina, additional, Karnani, Neerja, additional, Mustaniemi, Sanna, additional, Nawrot, Tim S., additional, Pattou, François, additional, Plusquin, Michelle, additional, Raverdy, Violeta, additional, Tan, Kok Hian, additional, Tzala, Evangelia, additional, Raikkonen, Katri, additional, Winkler, Christiane, additional, Ziegler, Anette-G., additional, Annesi-Maesano, Isabella, additional, Bouchard, Luigi, additional, Chong, Yap Seng, additional, Dabelea, Dana, additional, Felix, Janine F., additional, Heude, Barbara, additional, Jaddoe, Vincent W.V., additional, Lahti, Jari, additional, Reimann, Brigitte, additional, Vääräsmäki, Marja, additional, Bonnefond, Amélie, additional, Froguel, Philippe, additional, Hummel, Sandra, additional, Kajantie, Eero, additional, Jarvelin, Marjo-Riita, additional, Steegers-Theunissen, Regine P.M., additional, Howe, Caitlin G., additional, Hivert, Marie-France, additional, and Sebert, Sylvain, additional

Published
2022
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50. The emotional well‐being of parents with children at genetic risk for type 1 diabetes before and during participation in the POInT‐study.

Author

Houben, Janne, Janssens, Martha, Winkler, Christiane, Besser, Rachel Elizabeth Jane, Dzygalo, Katarzyna, Fehn, Annika, Hommel, Angela, Lange, Karin, Elding Larsson, Helena, Lundgren, Markus, Roloff, Frank, Snape, Matthew, Szypowska, Agnieszka, Weiss, Andreas, Zapardiel‐Gonzalo, Jose, Zubizarreta, Nicole, Ziegler, Anette‐Gabriele, and Casteels, Kristina

Subjects
WELL-being, PARENT attitudes, SOCIAL support, ORAL drug administration, TYPE 1 diabetes, MEDICAL screening, CONTENT mining, INSULIN, HEALTH care teams, DESCRIPTIVE statistics, QUESTIONNAIRES, EMOTIONS, PARENT-child relationships, ANXIETY, PARENTS, DISEASE risk factors, CHILDREN
Abstract

Introduction: This study examined the emotional impact that parents experience when confronted with an increased genetic risk of type 1 diabetes (T1D) in their child. Population‐based screening of neonates for genetic risk of chronic disease carries the risk of increased emotional burden for parents. Methods: Information was collected using a well‐being questionnaire for parents of infants identified as having an increased risk for T1D in a multinational research study. Parents were asked to complete this questionnaire after they were told their child had an increased risk for T1D (Freder1k‐study) and at several time points during an intervention study (POInT‐study), where oral insulin was administered daily. Results: Data were collected from 2595 parents of 1371 children across five countries. Panic‐related anxiety symptoms were reported by only 4.9% after hearing about their child having an increased risk. Symptoms of depression were limited to 19.4% of the parents at the result‐communication visit and declined over time during the intervention study. When thinking about their child's risk for developing T1D (disease‐specific anxiety), 47.2% worried, felt nervous and tense. Mothers and parents with a first‐degree relative (FDR) with T1D reported more symptoms of depression and disease‐specific anxiety (p < 0.001) than fathers and parents without a FDR. Conclusion: Overall, symptoms of depression and panic‐related anxiety are comparable with the German population. When asked about their child's risk for T1D during the intervention study, some parents reported disease‐specific anxiety, which should be kept in mind when considering population‐based screening. As certain subgroups are more prone, it will be important to continue psychological screening and, when necessary, to provide support by an experienced, multidisciplinary team. [ABSTRACT FROM AUTHOR]

Published
2022
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