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2. Prijsverschillen tussen dierlijke en plantaardige producten in de Nederlandse supermarkt : de ontwikkeling van prijsverschillen tussen dierlijk en plantaardig sinds 2022

Author

Winkel, D., Engen-Cocquyt, W. van, Haan, G., Simons, P., Winkel, D., Engen-Cocquyt, W. van, Haan, G., and Simons, P.

Abstract

Een verschuiving van dierlijke naar plantaardige eiwitten in ons dieet kan een grote bijdrage leveren aan de oplossing van veel maatschappelijke problemen. Zo is het opschuiven naar een voedingspatroon met meer plantaardige en minder dierlijke eiwitten beter voor het milieu en gezonder voor de meeste Nederlanders. Veel supermarkten hebben inmiddels doelen gesteld om minder dierlijke en meer plantaardige eiwitten te verkopen. Begin 2022 publiceerde Questionmark, in opdracht van ProVeg Nederland, een rapport dat de voedselprijzen van plantaardige en dierlijke alternatieven in Nederlandse supermarkten vergeleek (Questionmark, 2022a). Sinds maart 2022 hebben zich grote ontwikkelingen afgespeeld op het wereldtoneel, met een hoge (globale) inflatie tot gevolg, zoals ons tussentijds onderzoek eind 2022 ook al liet zien (Questionmark, 2022b). De consument merkt deze inflatie voornamelijk aan de gas- en energieprijzen, de benzineprijs en de dagelijkse boodschappen. Maar treffen deze prijsstijgingen de plantaardige en dierlijke producten in de supermarkt even zwaar?

Published
2024

4. Monitoring the healthiness of food environments in supermarkets and out-of-home settings

Author

Poelman, M.P., Dijkstra, C., Djojosoeparto, S., Winkel, D., Linnebank, C., Seidell, J., de Vet, E., Kamphuis, C., Poelman, M.P., Dijkstra, C., Djojosoeparto, S., Winkel, D., Linnebank, C., Seidell, J., de Vet, E., and Kamphuis, C.

Abstract

BackgroundFood environment transformations are needed to improve population diets. Systems to monitor food environment transformations are often lacking, but can be useful to assess retail and food-service performances over time. Therefore, we aimed to measure the healthiness of supermarkets and out-of-home settings, including the assortment, price promotions, in-store promotions, and food marketing to children.MethodsWeb-scraping techniques were used to collect data on food assortment (n = 37761 products) for 6 supermarket chains (market value=72%). All products were categorized by food group and whether they contributed to a healthy diet (yes/no). During 8 weeks, price-promotions were collected for 8 supermarket chains (n = 23239 promotions). To identify instore promotions (n = 7757 products) and food marketing to children (14 product categories, n = 2,681 products), 40 supermarkets (8 chains) were visited. Similar data was gathered for out-of-home settings.Results80% of the food assortment and 80% of the products featuring in supermarkets’ price- and in-store promotions were not supportive of a healthy diet. In addition, 73% of the check-outs offered snacks, but lacked healthy options. 97% of the food marketing to children was for products not supporting healthy diets. The top five most available food products in supermarkets were: non-alcoholic beverages, alcohol, sweets, biscuits, meat, and poultry (36% of the entire assortment). Non-alcoholic drinks, sweets and confections, alcoholic beverages, dairy, and ready-to-eat meals were the most featured products in price-promotions. Even less supportive observations were found for out-of-home settings.ConclusionsDutch food environments primarily consist of products and promotions that do not contribute to a healthy diet. Regular monitoring is needed to identify whether policies are effective to improve food environments.

Published
2023

6. Superlijst Gezondheid 2022

Author

Winkel, D., Haan, Gustaaf, van Engen-Cocquyt, W., de Jong, D., Antens, A., Nijpjes, P., Baelde Jansen, D., Dagevos, H., van Kleef, E., Roodenburg, Annet J.C., Seidell, Jaap C., Winkel, D., Haan, Gustaaf, van Engen-Cocquyt, W., de Jong, D., Antens, A., Nijpjes, P., Baelde Jansen, D., Dagevos, H., van Kleef, E., Roodenburg, Annet J.C., and Seidell, Jaap C.

Published
2022

8. Conservation status of the world's skinks (Scincidae): Taxonomic and geographic patterns in extinction risk

Author

Chapple, D.G. Roll, U. Böhm, M. Aguilar, R. Amey, A.P. Austin, C.C. Baling, M. Barley, A.J. Bates, M.F. Bauer, A.M. Blackburn, D.G. Bowles, P. Brown, R.M. Chandramouli, S.R. Chirio, L. Cogger, H. Colli, G.R. Conradie, W. Couper, P.J. Cowan, M.A. Craig, M.D. Das, I. Datta-Roy, A. Dickman, C.R. Ellis, R.J. Fenner, A.L. Ford, S. Ganesh, S.R. Gardner, M.G. Geissler, P. Gillespie, G.R. Glaw, F. Greenlees, M.J. Griffith, O.W. Grismer, L.L. Haines, M.L. Harris, D.J. Hedges, S.B. Hitchmough, R.A. Hoskin, C.J. Hutchinson, M.N. Ineich, I. Janssen, J. Johnston, G.R. Karin, B.R. Keogh, J.S. Kraus, F. LeBreton, M. Lymberakis, P. Masroor, R. McDonald, P.J. Mecke, S. Melville, J. Melzer, S. Michael, D.R. Miralles, A. Mitchell, N.J. Nelson, N.J. Nguyen, T.Q. de Campos Nogueira, C. Ota, H. Pafilis, P. Pauwels, O.S.G. Perera, A. Pincheira-Donoso, D. Reed, R.N. Ribeiro-Júnior, M.A. Riley, J.L. Rocha, S. Rutherford, P.L. Sadlier, R.A. Shacham, B. Shea, G.M. Shine, R. Slavenko, A. Stow, A. Sumner, J. Tallowin, O.J.S. Teale, R. Torres-Carvajal, O. Trape, J.-F. Uetz, P. Ukuwela, K.D.B. Valentine, L. Van Dyke, J.U. van Winkel, D. Vasconcelos, R. Vences, M. Wagner, P. Wapstra, E. While, G.M. Whiting, M.J. Whittington, C.M. Wilson, S. Ziegler, T. Tingley, R. Meiri, S.

Abstract

Our knowledge of the conservation status of reptiles, the most diverse class of terrestrial vertebrates, has improved dramatically over the past decade, but still lags behind that of the other tetrapod groups. Here, we conduct the first comprehensive evaluation (~92% of the world's ~1714 described species) of the conservation status of skinks (Scincidae), a speciose reptile family with a worldwide distribution. Using International Union for Conservation of Nature (IUCN) criteria, we report that ~20% of species are threatened with extinction, and nine species are Extinct or Extinct in the Wild. The highest levels of threat are evident in Madagascar and the Neotropics, and in the subfamilies Mabuyinae, Eugongylinae and Scincinae. The vast majority of threatened skink species were listed based primarily on their small geographic ranges (Criterion B, 83%; Criterion D2, 13%). Although the population trend of 42% of species was stable, 14% have declining populations. The key threats to skinks are habitat loss due to agriculture, invasive species, and biological resource use (e.g., hunting, timber harvesting). The distributions of 61% of species do not overlap with protected areas. Despite our improved knowledge of the conservation status of the world's skinks, 8% of species remain to be assessed, and 14% are listed as Data Deficient. The conservation status of almost a quarter of the world's skink species thus remains unknown. We use our updated knowledge of the conservation status of the group to develop and outline the priorities for the conservation assessment and management of the world's skink species. © 2021 Elsevier Ltd

Published
2021

9. Women's Empowerment at a Moroccan Supermarket: A Qualitative Investigation of Developed Competencies and Altered Relationships at an Emerging Retail Servicescape

Author

GODEFROIT-WINKEL, D., Penaloza, Liza, and Kedge Business School (Kedge BS)

Subjects
competencies, retailing, consumer culture, family, supermarket, capability, gender, women’s empowerment, [SHS]Humanities and Social Sciences
Abstract

International audience; This study bridges CCT and macromarketing perspectives in carrying out an ethnographic study examining how Moroccan women empower themselves in shopping in the supermarket. Our three-year ethnographic study in Casablanca among women and men illuminates the ways in which women develop new capabilities and alter social relations with family members, friends, store employees and customers. In turn, the interplay of women’s competencies, their interactions with men and women, and their socio-demographics of age and social class, together with supermarket characteristics, provide favorable conditions for the women to empower themselves. As women gain confidence to demonstrate their competencies and manifest their desires in leveraging their traditional nurturing roles and taking on tasks previously in the domain of men, they alter their relations with their husband and with the women who exercise control over them. Theoretical contributions contribute to knowledge of the importance of gender and family interactions as they impact the acquisition of key competencies in novel marketspaces through which women empower themselves, and generate further insight into the complex interweaving of market and social systems.

Published
2020
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10. Conservation status of the world's skinks (Scincidae): Taxonomic and geographic patterns in extinction risk

Author

Chapple, D.G., Roll, U., Bohm, M., Aguilar, R., Amey, A.P., Austin, C.C., Baling, M., Barley, A.J., Bates, M.F., Bauer, A.M., Blackburn, D.G., Bowles, P., Brown, R.M., Chandramouli, S.R., Chirio, L., Cogger, H., Colli, G.R., Conradie, W., Couper, P.J., Cowan, M.A., Craig, M.D., Das, I., Datta-Roy, A., Dickman, C.R., Ellis, R.J., Fenner, A.L., Ford, S., Ganesh, S.R., Gardner, M.G., Geissler, P., Gillespie, G.R., Glaw, F., Greenlees, M.J., Griffith, O.W., Grismer, L.L., Haines, M.L., Harris, D.J., Hedges, S.B., Hitchmough, R.A., Hoskin, C.J., Hutchinson, M.N., Ineich, I., Janssen, J., Johnston, G.R., Karin, B.R., Keogh, J.S., Kraus, F., LeBreton, M., Lymberakis, P., Masroor, R., McDonald, P.J., Mecke, S., Melville, J., Melzer, S., Michael, D.R., Miralles, A., Mitchell, N.J., Nelson, N.J., Nguyen, T.Q., de Campos Nogueira, C., Ota, H., Pafilis, P., Pauwels, O.S.G., Perera, A., Pincheira-Donoso, D., Reed, R.N., Ribeiro-Júnior, M.A., Riley, J.L., Rocha, S., Rutherford, P.L., Sadlier, R.A., Shacham, B., Shea, G.M., Shine, R., Slavenko, A., Stow, A., Sumner, J., Tallowin, O.J.S., Teale, R., Torres-Carvajal, O., Trape, J-F, Uetz, P., Ukuwela, K.D.B., Valentine, L., Van Dyke, J.U., van Winkel, D., Vasconcelos, R., Vences, M., Wagner, P., Wapstra, E., While, G.M., Whiting, M.J., Whittington, C.M., Wilson, S., Ziegler, T., Tingley, R., Meiri, S., Chapple, D.G., Roll, U., Bohm, M., Aguilar, R., Amey, A.P., Austin, C.C., Baling, M., Barley, A.J., Bates, M.F., Bauer, A.M., Blackburn, D.G., Bowles, P., Brown, R.M., Chandramouli, S.R., Chirio, L., Cogger, H., Colli, G.R., Conradie, W., Couper, P.J., Cowan, M.A., Craig, M.D., Das, I., Datta-Roy, A., Dickman, C.R., Ellis, R.J., Fenner, A.L., Ford, S., Ganesh, S.R., Gardner, M.G., Geissler, P., Gillespie, G.R., Glaw, F., Greenlees, M.J., Griffith, O.W., Grismer, L.L., Haines, M.L., Harris, D.J., Hedges, S.B., Hitchmough, R.A., Hoskin, C.J., Hutchinson, M.N., Ineich, I., Janssen, J., Johnston, G.R., Karin, B.R., Keogh, J.S., Kraus, F., LeBreton, M., Lymberakis, P., Masroor, R., McDonald, P.J., Mecke, S., Melville, J., Melzer, S., Michael, D.R., Miralles, A., Mitchell, N.J., Nelson, N.J., Nguyen, T.Q., de Campos Nogueira, C., Ota, H., Pafilis, P., Pauwels, O.S.G., Perera, A., Pincheira-Donoso, D., Reed, R.N., Ribeiro-Júnior, M.A., Riley, J.L., Rocha, S., Rutherford, P.L., Sadlier, R.A., Shacham, B., Shea, G.M., Shine, R., Slavenko, A., Stow, A., Sumner, J., Tallowin, O.J.S., Teale, R., Torres-Carvajal, O., Trape, J-F, Uetz, P., Ukuwela, K.D.B., Valentine, L., Van Dyke, J.U., van Winkel, D., Vasconcelos, R., Vences, M., Wagner, P., Wapstra, E., While, G.M., Whiting, M.J., Whittington, C.M., Wilson, S., Ziegler, T., Tingley, R., and Meiri, S.

Abstract

Our knowledge of the conservation status of reptiles, the most diverse class of terrestrial vertebrates, has improved dramatically over the past decade, but still lags behind that of the other tetrapod groups. Here, we conduct the first comprehensive evaluation (~92% of the world's ~1714 described species) of the conservation status of skinks (Scincidae), a speciose reptile family with a worldwide distribution. Using International Union for Conservation of Nature (IUCN) criteria, we report that ~20% of species are threatened with extinction, and nine species are Extinct or Extinct in the Wild. The highest levels of threat are evident in Madagascar and the Neotropics, and in the subfamilies Mabuyinae, Eugongylinae and Scincinae. The vast majority of threatened skink species were listed based primarily on their small geographic ranges (Criterion B, 83%; Criterion D2, 13%). Although the population trend of 42% of species was stable, 14% have declining populations. The key threats to skinks are habitat loss due to agriculture, invasive species, and biological resource use (e.g., hunting, timber harvesting). The distributions of 61% of species do not overlap with protected areas. Despite our improved knowledge of the conservation status of the world's skinks, 8% of species remain to be assessed, and 14% are listed as Data Deficient. The conservation status of almost a quarter of the world's skink species thus remains unknown. We use our updated knowledge of the conservation status of the group to develop and outline the priorities for the conservation assessment and management of the world's skink species.

Published
2021

11. Conservation status of the world's skinks (Scincidae): Taxonomic and geographic patterns in extinction risk

Author

Chapple, DG, Roll, U, Boehm, M, Aguilar, R, Amey, AP, Austin, CC, Baling, M, Barley, AJ, Bates, MF, Bauer, AM, Blackburn, DG, Bowles, P, Brown, RM, Chandramouli, SR, Chirio, L, Cogger, H, Colli, GR, Conradie, W, Couper, PJ, Cowan, MA, Craig, MD, Das, I, Datta-Roy, A, Dickman, CR, Ellis, RJ, Fenner, AL, Ford, S, Ganesh, SR, Gardner, MG, Geissler, P, Gillespie, GR, Glaw, F, Greenlees, MJ, Griffith, OW, Grismer, LL, Haines, ML, Harris, DJ, Hedges, SB, Hitchmough, RA, Hoskin, CJ, Hutchinson, MN, Ineich, I, Janssen, J, Johnston, GR, Karin, BR, Keogh, JS, Kraus, F, LeBreton, M, Lymberakis, P, Masroor, R, McDonald, PJ, Mecke, S, Melville, J, Melzer, S, Michael, DR, Miralles, A, Mitchell, NJ, Nelson, NJ, Nguyen, TQ, Nogueira, CDC, Ota, H, Pafilis, P, Pauwels, OSG, Perera, A, Pincheira-Donoso, D, Reed, RN, Ribeiro-Junior, MA, Riley, JL, Rocha, S, Rutherford, PL, Sadlier, RA, Shacham, B, Shea, GM, Shine, R, Slavenko, A, Stow, A, Sumner, J, Tallowin, OJS, Teale, R, Torres-Carvajal, O, Trape, J-F, Uetz, P, Ukuwela, KDB, Valentine, L, Dyke, JUV, van Winkel, D, Vasconcelos, R, Vences, M, Wagner, P, Wapstra, E, While, GM, Whiting, MJ, Whittington, CM, Wilson, S, Ziegler, T, Tingley, R, Meiri, S, Chapple, DG, Roll, U, Boehm, M, Aguilar, R, Amey, AP, Austin, CC, Baling, M, Barley, AJ, Bates, MF, Bauer, AM, Blackburn, DG, Bowles, P, Brown, RM, Chandramouli, SR, Chirio, L, Cogger, H, Colli, GR, Conradie, W, Couper, PJ, Cowan, MA, Craig, MD, Das, I, Datta-Roy, A, Dickman, CR, Ellis, RJ, Fenner, AL, Ford, S, Ganesh, SR, Gardner, MG, Geissler, P, Gillespie, GR, Glaw, F, Greenlees, MJ, Griffith, OW, Grismer, LL, Haines, ML, Harris, DJ, Hedges, SB, Hitchmough, RA, Hoskin, CJ, Hutchinson, MN, Ineich, I, Janssen, J, Johnston, GR, Karin, BR, Keogh, JS, Kraus, F, LeBreton, M, Lymberakis, P, Masroor, R, McDonald, PJ, Mecke, S, Melville, J, Melzer, S, Michael, DR, Miralles, A, Mitchell, NJ, Nelson, NJ, Nguyen, TQ, Nogueira, CDC, Ota, H, Pafilis, P, Pauwels, OSG, Perera, A, Pincheira-Donoso, D, Reed, RN, Ribeiro-Junior, MA, Riley, JL, Rocha, S, Rutherford, PL, Sadlier, RA, Shacham, B, Shea, GM, Shine, R, Slavenko, A, Stow, A, Sumner, J, Tallowin, OJS, Teale, R, Torres-Carvajal, O, Trape, J-F, Uetz, P, Ukuwela, KDB, Valentine, L, Dyke, JUV, van Winkel, D, Vasconcelos, R, Vences, M, Wagner, P, Wapstra, E, While, GM, Whiting, MJ, Whittington, CM, Wilson, S, Ziegler, T, Tingley, R, and Meiri, S

Published
2021

12. Dosimetric feasibility of hypofractionation for SBRT treatment of lymph node oligometastases on the 1.5T MR-linac

Author

Experimentele klinische fysica, Onderzoek Radiotherapie, Cancer, MS Radiotherapie, Klinische Fysica RT, Winkel, D, Werensteijn-Honingh, A M, Eppinga, W S C, Intven, M P W, Hes, J, Snoeren, L M W, Visser, S A, Bol, G H, Raaymakers, B W, Jürgenliemk-Schulz, I M, Kroon, P S, Experimentele klinische fysica, Onderzoek Radiotherapie, Cancer, MS Radiotherapie, Klinische Fysica RT, Winkel, D, Werensteijn-Honingh, A M, Eppinga, W S C, Intven, M P W, Hes, J, Snoeren, L M W, Visser, S A, Bol, G H, Raaymakers, B W, Jürgenliemk-Schulz, I M, and Kroon, P S

Published
2021

13. PO-1940 Online adaptive CBCT-guided VMAT radiotherapy using an Elekta Synergy CBCT-linac

Author

Groot Koerkamp, M., Bol, G., Kroon, P., Scheeren, A., Zoetelief, A., Krikke, L., Harderwijk, T., Plat, A., van der Vegt, S., Hes, J., van Gasteren, I., Schimmel-de Kogel, G., Renders, E., van Kaam, J., Onnink-Vijfvinke, R., Winkel, D., van Rijssel, M., Wopereis, A., Noteboom, J., van de Pol, S., Eppinga, W., van der Voort van Zyp, J., van Es, C., Bossenga, J., and Raaymakers, B.

Published
2023
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17. Rapid and sustained control of itch and reduction in Th2 bias by dupilumab in a patient with Sézary syndrome

Author

Steck, O, Bertschi, N.L., Luther, F., van den Berg, J, Winkel, D J, Holbro, A, and Schlapbach, C.

Subjects
610 Medicine & health
Abstract

BACKGROUND Sézary syndrome is a leukaemic variant of cutaneous T-cell lymphoma with poor prognosis. With the exception of stem cell transplantation, current treatments for SS are not curative. Rather, they aim at reducing disease burden and improving quality of life. Yet, pruritus - the major cause for impaired quality of life in these patients - is notoriously difficult to treat. Thus, supportive treatments addressing agonizing pruritus are urgently needed. OBJECTIVES To explore the clinical and immunological effects of type 2 cytokine blockade with dupilumab as supportive treatment in Sézary syndrome. METHODS A Sézary syndrome patient with stable disease but intractable pruritus was treated with dupilumab in combination with continued extracorporeal photopheresis. Close clinical and immunological monitoring on blood and skin samples from the patient was performed over 44 weeks. In vitro assays with patient's lymphoma cells were performed to address effects of dupilumab on Sézary cell's response to Th2 cytokines. RESULTS Clinically, dupilumab treatment induced rapid and sustained reduction in itch and improvement of skin and lymph node involvement. In both blood and skin, a reduction in Th2 bias was observed. Intriguingly, lymphocyte counts and Sézary cells in blood increased and later stabilized under dupilumab treatment. In vitro, dupilumab abrogated the anti-apoptotic and activating effects of Th2 cytokines on Sézary cells. CONCLUSIONS In this Sézary patient, inhibition of IL-4 and IL-13 signalling was associated with striking clinical benefit in terms of quality of life, pruritus and use of topical corticosteroids. While safety remains an important concern, our data support the future exploration of Th2 modulation for supportive care in Sézary Syndrome.

Published
2020
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18. Workshop III Report: Scaleup of Liquid and Semisolid Disperse Systems

Author

Buskirk, G. A. Van, Shah, V. P., Adair, D., Arbit, H. M., Dighe, S. V., Fawzi, M., Feldman, T., Flynn, G. L., González, M. A., Gray, V. A., Guy, R. H., Herd, A. K., Hem, S. L., Hoiberg, C., Jerussi, R., Kaplan, A. S., Lesko, L. J., Malinowski, H. J., Meltzer, N. M., Nedich, R. L., Pearce, D. M., Peck, G., Rudman, A., Savello, D., Schwartz, J. B., Schwartz, P., Skelly, J. P., Vanderlaan, R. K., Wang, J. C. T., Weiner, N., Winkel, D. R., and Zatz, J. L.

Published
1994
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24. EP-1624 First clinical experiences with SBRT on the 1.5 T MR-linac for pelvic lymph node oligometastases

Author

Werensteijn-Honingh, A.M., primary, Kroon, P.S., additional, Winkel, D., additional, Aalbers, E.M., additional, Van Asselen, B., additional, Bol, G.H., additional, Brown, K.J., additional, Eppinga, W.S.C., additional, Glitzner, M., additional, Breugel, E.N. De Groot-van, additional, Hackett, S.L., additional, Intven, M., additional, Kok, J.G.M., additional, Kotte, A.N., additional, Lagendijk, J.J.W., additional, Philippens, M.E.P., additional, Tijssen, R.H.N., additional, Wolthaus, J.W.H., additional, Woodings, S.J., additional, Raaymakers, B.W., additional, and Jürgenliemk-Schulz, I.M., additional

Published
2019
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26. Adaptive radiotherapy: The Elekta Unity MR-linac concept

Author

Winkel, D., Bol, G.H., Kroon, P.S., Asselen, B. van, Hackett, S.S., Werensteijn-Honingh, A.M., Intven, M.P.W., Eppinga, W.S.C., Tijssen, R.H.N., Kerkmeijer, L.G.W., Boer, H.C. de, Mook, S., Meijer, G.J, Hes, J., Willemsen-Bosman, M., Breugel, E.N. de Groot-van, Jurgenliemk-Schulz, I.M., Raaymakers, B.W., Winkel, D., Bol, G.H., Kroon, P.S., Asselen, B. van, Hackett, S.S., Werensteijn-Honingh, A.M., Intven, M.P.W., Eppinga, W.S.C., Tijssen, R.H.N., Kerkmeijer, L.G.W., Boer, H.C. de, Mook, S., Meijer, G.J, Hes, J., Willemsen-Bosman, M., Breugel, E.N. de Groot-van, Jurgenliemk-Schulz, I.M., and Raaymakers, B.W.

Abstract

Contains fulltext : 215382.pdf (publisher's version ) (Open Access), Background and purpose: The promise of the MR-linac is that one can visualize all anatomical changes during the course of radiotherapy and hence adapt the treatment plan in order to always have the optimal treatment. Yet, there is a trade-off to be made between the time spent for adapting the treatment plan against the dosimetric gain. In this work, the various daily plan adaptation methods will be presented and applied on a variety of tumour sites. The aim is to provide an insight in the behavior of the state-of-the-art 1.5T MRI guided on-line adaptive radiotherapy methods. Materials and methods: To explore the different available plan adaptation workflows and methods, we have simulated online plan adaptation for five cases with varying levels of inter-fraction motion, regions of interest and target sizes: prostate, rectum, esophagus and lymph node oligometastases (single and multiple target). The plans were evaluated based on the clinical dose constraints and the optimization time was measured. Results: The time needed for plan adaptation ranged between 17 and 485s. More advanced plan adaptation methods generally resulted in more plans that met the clinical dose criteria. Violations were often caused by insufficient PTV coverage or, for the multiple lymph node case, a too high dose to OAR in the vicinity of the PTV. With full online replanning it was possible to create plans that met all clinical dose constraints for all cases. Conclusion: Daily full online replanning is the most robust adaptive planning method for Unity. It is feasible for specific sites in clinically acceptable times. Faster methods are available, but before applying these, the specific use cases should be explored dosimetrically.

Published
2019

28. Entrepreneurship as a career choice: intentions, attitudes, and outcome expectations.

Author

Liguori, E., Winkler, C., Vanevenhoven, J., Winkel, D., and James, M.

Subjects
ATTITUDE (Psychology), SOCIAL cognitive theory, MOTIVATION (Psychology), INTENTION, SOCIAL support
Abstract

Copyright of Journal of Small Business & Entrepreneurship is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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31. 1.5T MRI-Linac treatment planning for multiple lymph node oligometastases in the pelvic area

Author

Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Experimentele klinische fysica, Kiekebosch, I. H., Winkel, D., Werensteijn-Honingh, A. M., Hes, J., Intven, M. P. W., Eppinga, W. S. C., Bol, G. H., Raaymakers, B. W., Jurgenliemk-Schulz, I. M., Kroon, P. S., Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Experimentele klinische fysica, Kiekebosch, I. H., Winkel, D., Werensteijn-Honingh, A. M., Hes, J., Intven, M. P. W., Eppinga, W. S. C., Bol, G. H., Raaymakers, B. W., Jurgenliemk-Schulz, I. M., and Kroon, P. S.

Published
2018

32. Dose escalation and hypofractionation for SBRT of lymph node oligometastases on the 1.5T MRI-Linac

Author

Cancer, Klinische Fysica RT, Onderzoek Radiotherapie, MS Radiotherapie, Experimentele klinische fysica, Winkel, D., Bol, G., Werensteijn-Honingh, A., Kiekebosch, I., Hes, J., Intven, M., Eppinga, W., Raaymakers, B., Jurgenliemk-Schulz, I., Kroon, P., Cancer, Klinische Fysica RT, Onderzoek Radiotherapie, MS Radiotherapie, Experimentele klinische fysica, Winkel, D., Bol, G., Werensteijn-Honingh, A., Kiekebosch, I., Hes, J., Intven, M., Eppinga, W., Raaymakers, B., Jurgenliemk-Schulz, I., and Kroon, P.

Published
2018

35. Development and clinical introduction of automated radiotherapy treatment planning for prostate cancer

Author

Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiotherapie, Other research (not in main researchprogram), Experimentele klinische fysica, Winkel, D, Bol, G H, van Asselen, B, Hes, J, Scholten, V, Kerkmeijer, L G W, Raaymakers, B W, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiotherapie, Other research (not in main researchprogram), Experimentele klinische fysica, Winkel, D, Bol, G H, van Asselen, B, Hes, J, Scholten, V, Kerkmeijer, L G W, and Raaymakers, B W

Published
2016

40. QUANTITATIVE ANALYSIS OF TRACTION IN THE GLENOHUMERAL JOINT. IN VIVO ROENTGENOGRAPHIC MEASUREMENTS

Author

DeClerck, S, Matthijs, O, Gokeler, A, van Paridon-Edauw, GH, and Winkel, D

Subjects
Joints -- Range of motion, Shoulder joint -- Care and treatment
Abstract

PURPOSE: Joint mobilization by means of fraction is a technique frequently applied by physical therapists treating shoulder patients in daily practice. According to the literature the effects are based on separating the humeral head from the glenoid cavity, thus stretching of the collagenous tissues. No studies have been done in vivo to determine if separation indeed occurs. Based on a preliminary study we hypothesized that fraction does not result in an increase of the glenohumeral joint (GHJ) space more than 1 mm in healthy subjects. SUBJECTS: Six healthy subjects (3 male and 3 female) with an average age of 40.5 years, volunteered to participate in this study. MATERIALS AND METHODS: All subjects were placed with the right shoulder in a modified shoulder brace (Otto Bock Armabduktions-Orthese in Modular Bauweise[R]) that held the shoulder in 45 [degrees] abduction in the plane of the scapula with neutral rotation, corresponding to the maximally loose packed position (MLPP). The scapula was additionally fixated with a Soft Belt[R]. A 14 kilogram force of fraction was applied by a therapist for 40 seconds to the GHJ before a roentgenographic film was taken. The same procedure was repeated with the shoulder placed in the closed packed position (CPP) of 90 [degrees] abduction and 90 [degrees] external rotation. Measurements were made by a radiologist blinded to the variable pull force or no pull force applied. ANALYSES AND RESULTS: Mean GHJ space in the MLPP increased from 4.33 mm without traction to 4.58 mm with traction, while in the CPP it increased from 4.83 mm to 5.08 mm with traction. The Wilcoxon Signed-Ranks test was used to determine statistical significance of the results. No statistically significant changes in joint space were found in the MLPP (p=0.02) and in the CPP (p=0.18). CONCLUSIONS: Application of a 14 kilogram force perpendicular to the glenoid fossa does not result in a significant separation of the humeral head from the glenoid fossa in subjects with no known shoulder pathologies. Joint play testing of the GHJ in healthy subjects by means of traction to test GHJ mobility, appears not to be useful since no significant separation of the GHJ occurs. Further studies are needed to determine if GHJ traction may result in GHJ separation in subjects with shoulder pathologies., DeClerck S, Matthijs O, Gokeler A, van Paridon-Edauw GH and Winkel D; BVBA Medische Beeldvorming, Schofen, [...]

Published
2000

41. CT perfusion-based prediction of final tissue status in cerebral ischemia

Author

Winkel, D., Vos, P.C. (Thesis Advisor), Winkel, D., and Vos, P.C. (Thesis Advisor)

Abstract

CT Perfusion offers us some great diagnostic features for neuroimaging and has great potential in the field of acute ischemic strokes. Over the last few years more research is being conducted regarding the prediction of final tissue status in cerebral ischemia. The goal of this research is to automatically or semi-automatically differentiate between infarct core lesion and ischemic penumbra. Some commercially available packages already provide such features, but are not always as accurate. Much research is ongoing in more specialized institutes featuring different methods like thresholding, functional clustering and more advanced methods such as the use of artificial neural networks. Results look promising but we should remain critical before applying it in clinical settings due to the fact that most current research is being conducted on homogeneous data sets and is not clinically validated.

Published
2015

46. Wat is er mis met (kweek)vis?!

Author

Winkel, D. and Winkel, D.

Abstract

De Stichting Vissenbescherming is in 2000 opgericht om mensen diervriendelijker en respectvoller om te laten gaan met vissen en andere in het water levende dieren. Dos Winkel bespreekt wat er mis is met onze oceanen en zeeën, zoals overbevissing en gigantische bijvangsten waar per jaar zo'n 30-35 miljard kilo vis, die dood of verminkt overboord gekieperd wordt.

Published
2009

47. Giftige vis : vraagtekens bij visconsumptie

Author

Winkel, D. and Winkel, D.

Abstract

Vis is gezond. Vooral vanwege de aanwezigheid van onverzadigde 'omega-vetzuren' wordt vis algemeen beschouwd als hét gezonde alternatief voor vlees. Dos Winkel plaatst echter vraagtekens bij de gezondheidsclaim op vis en visolie

Published
2009

48. Wat is er precies bekend over de effecten van vis en visproducten op de menselijke gezondheid?

Author

Winkel, D. and Winkel, D.

Abstract

In zijn nieuwste boek ''Wat is er mis met vis?! en visolie'', bespreekt Dos de Winkel wat er mis is met onze oceanen en zeeën. Iedereen weet dat vis gezonde bestanddelen bevat, met name (dierlijke) eiwitten en derivaten van Omega-3. Slechts weinigen weten dat Omega-3 niet door de vissen zelf gemaakt wordt, maar dat zij die binnen krijgen met hun voeding. In dit artikel worden de resultaten van onderzoek naar de effecten van Omega-3 vetzuren op een aantal menselijke gezondheidsproblemen opgesomd

Published
2009

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